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Mathematical Modeling of Complex Biological Systems: From Parts Lists to Understanding Systems Behavior


[...] new techniques to manipulate cells in a directed manner allow researchers to perturb biological systems under controlled conditions.\n In most cases, multiple research centers or companies are integrated in a decentralized research network to which investigators from numerous disciplines (e.g., biology, genetics, biochemistry, physics, mathematics, computer sciences, statistics, or engineering) contribute (see table, p. 58). Just as an engineer can turn a heap of metal pieces, wires, screws, and bolts into a jet plane only if he has a comprehensive blueprint, biomedical scientists can understand the workings of living organisms only if they have comprehensive models that enable them to connect the often disparate pieces of information derived from experimental approaches.

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									                   Mathematical Modeling of

                   Complex Biological Systems 

                                     From Parts Lists to 

                               Understanding Systems Behavior

                                                  Hans Peter Fischer, Ph.D.

           To understand complex biological systems such as cells, tissues, or even the human body, it is not sufficient to
           identify and characterize the individual molecules in the system. It also is necessary to obtain a thorough
           understanding of the interaction between molecules and pathways. This is even truer for understanding
           complex diseases such as cancer, Alzheimer’s dis
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