Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor by ProQuest

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									Copyright Ó 2008 by the Genetics Society of America
DOI: 10.1534/genetics.107.070813



       Clustering of Genetically Defined Allele Classes in the Caenorhabditis
                      elegans DAF-2 Insulin/IGF-1 Receptor

              Dhaval S. Patel,*,1 Acely Garza-Garcia,†,‡ Manoj Nanji,* Joshua J. McElwee,*,2
                        Daniel Ackerman,* Paul C. Driscoll†,‡ and David Gems*,3
 *Department of Biology, and †Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, United
      Kingdom and ‡Division of Molecular Structure, National Institute for Medical Research, London NW7 1AA, United Kingdom
                                                     Manuscript received January 11, 2007
                                                 Accepted for publication November 27, 2007


                                                              ABSTRACT
                The DAF-2 insulin/IGF-1 receptor regulates development, metabolism, and aging in the nematode
             Caenorhabditis elegans. However, complex differe
								
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