Grapefruit is well-known for interfering with liver enzymes that eliminate certain medications, such as cholesterol-lowering drugs, so the blood levels of these medicines can climb to dangerous levels. It may cause headaches, fatigue, dizziness, low blood pressure, and constipation (or the opposite), although a brief juice fast is much less likely to trigger these problems than a juice fast that lasts more than a few days or a water fast (both of which should be done only under the guidance of a qualified professional who knows your health history). It's also not generally recommended for people who are underweight or who have diabetes, hypoglycemia, low blood pressure, eating disorders, liver or kidney diseases, anemia, immune disorders, cancer, or seizures.
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