Molecular Pharmacology of G Protein-Coupled Receptors, 2008

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					                 Molecular Pharmacology of G Protein-Coupled
                 Receptors, 2008
November 13th - 15th, 2008: Victor Chang Cardiac Research Institute, Sydney, New
South Wales, Australia

Final Program

5th International meeting on the "Molecular Pharmacology of G Protein-Coupled Receptors"
[MPGPCRs 2008]

Thursday November 13th
Registration 2pm-4pm                               Burton St Entrance, Garvan Institute

      Princesses Lecture (NAB Auditorium, Garvan Institute)
Sponsored by the Victor Chang Cardiac Research Institute

4pm- 5pm      Richard Henderson             (UK)
              Talk Title: Structural changes underlying function in 7-helix membrane
              proteins including GPCRs

5pm – 5.30pm    1 Minute Poster Talks
5.30pm – 8.30pm Poster Session I (Garvan Foyer, Level 4)

              Casual dinner (finger food) will accompany the poster session

Friday November 14th
RJ Summers Symposium
      Ligand-directed trafficking of receptor stimulus (Victor Chang Building, Seminar
Room Level 4)
Sponsored by Monash University, Faculty of Medicine, Nursing and Health Sciences

9am-9:30am           Roger Summers                 (Australia)
                     Talk Title: Ligand-directed signalling at the β3-adrenoceptor

9:30am-10am          Michel Bouvier               (Canada)
                     Talk Title: Molecular determinants of ligand-biased signalling at

10am-10:30am         Roger Sunahara                  (USA)
                     Talk Title: Allosteric regulation of ligand binding to GPCRs by G

10:30am-11am         Tea (Victor Chang Building)
             Early career symposium (Victor Chang Building, Seminar Room Level 4)

11am-11:20am        Debbie Hay                      (New Zealand)
                    Talk Title: Identification of key residues for receptor activity-modifying
                    protein function

11:20am-11:40am     Celine Valant                     (Australia)
                    Talk Title: A novel mechanism of G protein-coupled receptor
                    functional selectivity: Muscarinic partial agonist McN-A-343 as a
                    bitopic orthosteric/allosteric ligand

11:40am-12pm        Stephane Angers              (Canada)
                    Talk Title: Investigating GPCR signal transduction using functional

12pm-12:20pm        Gunnar Schulte                 (Sweden)
                    Talk Title: The role of beta-arrestin for WNT-Frizzled signalling

12:20pm-1:30pm      Lunch (Victor Chang Building)

      Allosteric drugs and mechanisms (NAB Auditorium, Garvan Institute)
Sponsored by Addex Pharmaceuticals

1:30pm-2pm          Arthur Christopoulos         (Australia)
                    Talk Title: GPCR allosterism: The challenge of permissive receptor

2pm-2:30pm          Klaus Mohr                      (Germany)
                    Talk Title: Bitopic allosteric/orthosteric GPCR targeting: a novel route
                    to binding and signalling pathway selectivity

2:30pm-3pm          Arthur Conigrave              (Australia)
                    Talk Title: Nutrient sensing by class III GPCRs: Structure-function

3pm-3:30pm          Tea (Garvan)

      Receptor Signalling (NAB Auditorium, Garvan Institute)

3:30pm-4pm          Mark von Zastrow            (USA)
                    Talk Title: Endocytic membrane traffic of G protein-coupled receptors

4pm-4:30pm          Graeme Henderson             (UK)
                    Talk Title: Multiple mechanisms of µ-opioid receptor desensitisation

4.30pm-5pm 1 Minute Poster Talks
5pm-7pm    Poster Session II (Garvan Foyer, Level 4)

7pm-late     Conference Dinner (Victor Chang Building, Seminar Room Level 4)

             After Dinner Speaker – Nick Hunt           (Australia)
                                  Talk Title: GPCRs in the third millennium
Saturday November 15th
         Regulation/novel technologies/late breaking science (NAB Auditorium, Garvan
Sponsored by Merck & Co.

9am-9:30am          Jane Murphy         (USA)
                    Talk Title: Endosomal proteases regulate trafficking and signalling of
                    internalized GPCRs

9:30am-10am         David Fairlie                 (Australia)
                    Talk Title: Regulating protein/peptide-activated GPCRs

10am-10:30am        Tsutomu Kouyama                (Japan)
                    Talk Title: Crystal structures of archaeal and invertebrate rhodopsins

10:30am-11am        Tea (Garvan)

      Student oral prize symposium (NAB Auditorium, Garvan Institute)

11am-11:15am        Vindhya Nawaratne (Australia)
                    Mutational analysis of the M4 muscarinic acetylcholine receptor

11:15am-11:30am     Emily Stoddart (Australia)
                    New α1 adrenergic receptor pharmacophores exhibit a high ’hit’ rate:
                    An emerging alternative tool for drug discovery

11:30am-11:45am     Greg Stewart (Australia)
                    Pharmacological characterisation of the M3 muscarinic acetylcholine
                    receptor in Saccharomyces cerevisiae

11:45am-12pm        Marie-Laure Rives (France)
                    Integration of a transduction signal resulting from cross talk between
                    GPCRs without direct interaction

12pm-12:15pm        Karen Gregory (Australia)
                    Differential effects on allosteric agonism by mutations in the
                    orthosteric and allosteric pockets of M2 muscarinic acetylcholine

12:15pm-12:30pm     Ajanthy Arulpragasam (Australia)
                    The 14-3-3 isoforms theta and zeta bind the calcium-sensing receptor
                    and modulate receptor signalling through the Rho pathway, but not the
                    ERK 1/2 pathway

12:30pm-1:30pm      Lunch

      Receptor structure I (NAB Auditorium, Garvan Institute)

1:30pm-2pm          Brian Kobilka                (USA) Sponsored by Beckman Coulter
                    Talk Title: Structure and dynamics of the human beta 2 adrenoceptor
2pm-2:30pm          Gebhard Schertler              (UK)    Sponsored by Marresearch
                    Talk Title: Structure of a beta 1 adrenergic receptor: Implication for
                    GPCR signalling and pharmacology

2:30pm-3pm          Rama Ranganathan              (USA)
                    Talk Title: Evolutionary design of protein structure and function

3pm-3:30pm          Tea (Garvan)

      Receptor structure II (NAB Auditorium, Garvan Institute)

3:30pm-4pm          Shaun Coughlin                (USA)
                    Talk Title: Protease-activated receptors in vascular biology and

4pm-4:30pm          Larry Miller                  (USA)
                    Talk Title: Secretin receptor dimerization: a possible functionally-
                    important paradigm for Family B G protein-coupled receptors

4:30pm-4:45pm       Prizes and close (NAB Auditorium, Garvan Institute)