acute lung injury
Antonio Fabron Junior1,Larissa Barbosa
Lopes2,Jose Orlando Bordin3
J Bras Pneumol 2007;33(2):206-212
˙Transfusion-related acute lung injury (TRALI)
was recognized as a clinical in 1980.
˙TRALI is a clinical syndrome.
˙Principally those originating from multiparous
˙TRALI is a serious complication related to the
transfusion of plasma-containing blood
˙Reaction typically includes fever, chills, and
hypotension, usually occurring during or within
1 to 2 after transfusion.
HLA class Ⅰ、classⅡor HNA →
Canada blood developed such a definition
Acute lung injury (ALI) syndrome:
Use ex-vivo rabbit lung
Laboratory test-based diagnosis gold
Donor antibodies detected
Recipient lymphocyte/granulocyte antigens
No specific treatment for TRALI.
治療低血氧→oxygen therapy and ventilatory
治療低血壓→ vasopressor agents.
80% TRALI patients resolution of the pulmomary
infiltration within the first 4 days.
TRALI mortality is estimated at 5 to 10%.
1.Leukoreduction of blood components prior to
2.Blood components of removing antibodies,
lipids of plasma fraction.
3.Storing products for shorter periods avoid the
effect of substances that accumulate during
storage and that could induce TRALI.
˙TRALI pathogenesis mechanisms, treatment and
prevention remain little understanding.
˙Infusion of anti-HLA antibodies into the
recipient in susceptible individuals.
˙Support therapy is the treatment recommended
for most TRALI patients.
˙In addition, without a clear understanding of the
TRALI etiology, restrictions on donor might be
˙The resolution of TRALI frequently occurs
rapidly and does not have any long-term.
Thank you for your attention