Novel Protein Drug Delivery Syst

							Protein Drug Delivery System

             Team Members:
      Austin Ramme- Team Leader
         Michael Haggerty- BSAC
        Andrew Neumann- BWIG
    Sarajane Stevens- Team Leader-IT
       Becky Koszalinski- BSAC-IT
     Christopher Westphal- BWIG-IT


                Advisor:
          Professor Mitch Tyler
Presentation Outline
   Problem Statement
   Background Information
   Current Devices
   Research Competition
   Design Constraints
   Alternative Designs
   Future Work
         Problem Statement
 Client: Michael J. MacDonald, MD
 Diabetes Type I
 Protein Drug Delivery System
  – Inexpensive
  – Constant Injection Rate
  – Disposable
       Background Information


 Diabetes Type I
  – Immune system
  – Glucose level in the blood
  – Juvenile onset diabetes
  – Injections/Pumps
       Background Information

 Insulin
   – Protein-based drug
   – Onset, peaktime, duration
   – 5 to 10 units/day
       Unit = 0.01 mL
 Protein Drugs
   – Skin, ingestion, injection
 Injection sites
 Current Devices: Insulin Pumps

 Insulin syringe (3)
 Battery operated pump (2)
   – Computer controlled
 Infusion set (1)
   – Tube
   – Needle (soft or metal)
 Very expensive ($5,000 –
  $7,500)
Research Competition

           Professor Beebe
           Hydrogels
            – Stimuli cause
              expansion in gel
            – Currently toxic
            – Non-linear expansion
            – Wound-dressings
            – Easy to mold
         Suggested Materials
 Metering Valves
  – Controls flow
  – Chromatography
 NanoMuscles
  – Contract like human
    muscle
  – Rotational or linear motion
 Expandable Materials
Design Constraints
   Inexpensive
   Disposable
   Sterile
   Constant flow
   8-24 hour delivery time
   Scaled up prototype
Design I: Constant Pressure Device
                             60mm



                                                     15mm
    Drug
    Reservoir


                To Infusion Set     Metering Valve



   Disk shaped reservoir (60mm diameter)
   Spring applies constant pressure
   Metering valve controls flow rate
 Design I: Advantages & Disadvantages

 Advantages                  Disadvantages
  – Compact                       – Awkward
  – Flexible                      – Health risks
  – Cost efficient                – Advanced technology

                     60 mm




       15 mm




                             To Infusion Set
  Design II: Bulb Gravity Box
           One-Way Valve           Ten scale
                                   Two chamber
                                   Separation membrane
                     Air Bulb      Uses gravity
                                   Air pressure
Metering Valve
                                   Adhesive

  Needle         Diaphragm
Design II: Advantages & Disadvantages

 Advantages
  – Easy filling
  – Inexpensive materials
                            Chamber 2
  – Constant flow rate

 Disadvantages
  – Patient interactions    Chamber 1
  – Separation membrane
  – Bulkiness
Design III: NanoMuscle-Monstrosity (NMM)

Batteries in series
NanoMuscle
Syringe
Wire-Needle
Flesh colored tube
Adhesive
undercoating
Design III: Advantages & Disadvantages
  Advantages               Disadvantages
   – Refilling procedure     – NanoMuscles
   – Materials               – Shape/Size
   – NanoMuscles
                Future Work
   Flow rate and pressure calculations
   NanoMuscle research
   Metering valve search
   Constructing prototype
   Test prototype
                                           References
[1]    Ahern J, Mazur ML. Apr 2001. Site Rotation. Diabetes Forecast. 54,4:66-68.
[2]    Anonymous. Jan 2004. Insulin Administration. Diabetes Care. 27:S106-S109.
[3]    The Basics of Insulin. American Diabetes Association. 16 Sept 2004. <http://www.diabetes.org/type-1-diabetes/basics.jsp>.
[4]    Campbell, R. Keith. “Update on Insulin Injection Devices.” U.S. Pharmacist. 16 Sept 2004.
       <http://www.uspharmacist.com/oldformat.asp?url=newlook/files/Feat/may00insulin.cfm>.
[5]    Diabetes Mellitus. Microsoft® Encarta® Online Encyclopedia 2004. 10 Sept 2004.
                  <http://encarta.msn.com>.
[6]    Flow Rate Calculations. 15 Sept. 2004. <http://www.ecsel.psu.edu/~tac167/flowcalcs.htmL>.
[7]    Fluid Systems. 15 Sept 2004. <http://claymor.engineer.gvsu.edu/jackh/books/model/chapters/fluids.pdf>.
[8]    Fomo Products, Inc. 24 Sept 2004. <http://www.fomo.com/msds/a16150.pdf >.
[9]    Hydrostatic Pressure in a Liquid. 15 Sept 2004. <http://www.ac.wwu.edu/~vawtr/PhysicsNet/Topics/Pressure/Hydrostatic.htmL>.
[10]   Insulin Routines. American Diabetes Association. 16 Sept 2004 <http://www.diabetes.org/type-1-diabetes/injections.jsp>.
[11]   Insulin Storage and Syringe Safety Information. American Diabetes Association. 16 Sept 2004. <http://www.diabetes.org/type-1-
       diabetes/safety.jsp>.
[12]   Insulin Pump 101. 19 Sept 2004. <http://www.banting.com/tcenter/pump101.htmL>.
[13]   Insulin Pumps. American Diabetes Association. 10 Sept 2004. http://www.diabetes.org/type-1-diabetes/insulin-pumps.jsp
[14]   Lumber T. Jul 2004. Tips for Site Rotation. Diabetes Forecast. 57,7:68-70.
[15]   Kempinger, Jayson. Personal Interview: Austin Ramme. 25 Sept 2004.
[16]   Micro-Forged Metering Valves. Hoke, Inc. 15 Sept 2004. <http://www.hoke.com/pdf/1600_series.pdf>.
[17]   Micro Needle Valves. Scientific Instrument Services. 15 Sept 2004. <http://www.sisweb.com/catalog/?page=D64>.
[18]   Nanomucles. 21 Sept 2004. <http://www.nanomuscle.com/products/tech.htmL>.
[19]   Protein-Based Drugs: A Look Through The Crystal Ball. American Diabetes Association. 20 Sept 2004.
       <http://www.diabetesincontrol.com/modules.php?name=News&file=article&sid=599>.
[20]   Puccinelli, John. Personal Interview: Christopher Westphal. 30 Sept 2004.
[21]   Pump Basics. 18 Sept 2004. <http://www.childrenwithdiabetes.com/pumps/basics.htm>.
[22]   P-445,P-446 Micro-Metering Valve. Western Analytical Products. 15 Sept 2004. <http://www.westernanalytical.com/upchurch/micro-
       metering.htm>.
[23]   Tight Diabetes Control. American Diabetes Association. 16 Sept 2004. <http://www.diabetes.org/type-1-diabetes/tight-control.jsp>.
[24]   The three skin layers: epidermis, dermis, subcutaneous fat. 18 Sept 2004. <www.pg.com/science/skincare/Skin_tws_10.htm>.
[25]   ZeroDraft Professional Weatherization Materials. 24 Sept 2004.
                  <http://www.canambuildingenvelope.com/files/pdfs/330-1074.pdf>.
Questions?