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Mary Gant - National Council for

VIEWS: 12 PAGES: 27

									Funding Opportunities in Environmental
          Health Sciences

    National Institute of Environmental Health Sciences
                      26 March 2007
                        Mary Gant
                          NIEHS
         Public Health Service Act

The general purpose of the National Institute of
Environmental Health Sciences is the conduct and support of
research, training, health information dissemination, and
other programs with respect to factors in the environment
that affect human health, directly or indirectly.
   Superfund Amendment and Reauthorization
                 Act of 1986
Established at NIEHS a university-based multidisciplinary grants
program to fund research on the following:

   •Technologies to detect and trace the movement of hazardous
   substances in the environment

   •Biological, chemical, and physical methods to reduce the
   amount and toxicity of hazardous substances in the
   environment

   •Health effects of hazardous substances and methods to assess
   the risks to health presented by hazardous substances
Superfund Amendment and Reauthorization
              Act of 1986

 • Established at NIEHS a grants program to train workers
   who are or may be engaged in activities related to
   hazardous waste removal or containment or emergency
   response.
 • Grants are awarded to nonprofit organizations that
   demonstrate experience in implementing and operating
   worker health and safety training programs and that
   demonstrate an ability to reach target populations of
   workers.
     Longstanding Extramural Program Strengths
Basic Biology              Public Health
  – Oxidative stress         – Lead and IQ
  – DNA Repair               – Air Pollution and Mortality
  – Apoptosis                – Pesticides and Reproduction
  – Gene regulation          – Arsenic and Cancer
  – Mutagenesis              – Mercury and Neurodevelopment
  – Endocrine disruption     – Aflatoxin and Cancer
  – Metabolism
  – Receptor Biology
  – Signal transduction
  – Development
 TOP PRIORITY—INVESTIGATOR-
     INITIATED RESEARCH!

      NIEHS recognizes the importance of
  investigator-initiated research and a balance
between this and targeted programs. Our goal
is to fund at least 20% of the R01 applications.
                                NIEHS Budget History
                                       FY 1998 - FY 2008
            800
                                                                   $724
                                                            $711          $715   $720    $716
                                                     $698
            700
                                              $645

            600                        $565

                                $505
            500
$ million




                         $437
                  $390
            400

            300

            200

            100

              0
                  1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008
                         Superfund     Res Centers     Other Extramural   DIR    Other
NIEHS 2006-2011
Strategic Plan
New Frontiers in
Environmental
Sciences and Human
Health
The Strategic Plan in Action
   .
   • Build integrated environmental health research programs to address the
     cross-cutting problems in human biology and human disease
       – DISCOVER (Disease Investigation for Specialized Clinically Oriented Ventures in
         Environmental Research): brings together basic, clinical, and population-based scientists
         to conduct integrative research programs
       – Interdisciplinary Partnerships in Environmental Health Sciences

   • Develop sensitive markers of environmental exposure, early (preclinical)
     biological response and genetic susceptibility.
       – Genes and Environment Initiative: Launched by NIH to accelerate the understanding of
         how genetic and environmental risk factors influence health and disease
       – Environmental Sensors for Personal Exposure Assessment
       – Biological Response Indicators of Environmental Stress Centers
       – Biological Response Indicators of Environmental Stress

   • Use environmental toxicants to understand basic mechanisms in human
     biology
       – Comparative Biology Elucidation of Environmental Pathways and Susceptibility
       – Environmental Influences on Epigenetic Regulation
The Strategic Plan in Action
   .
   • Recruit and Train the next generation of environmental health scientists:
       – ONES (The Outstanding New Environmental Scientist Award): to advance young
         researchers through the award their first R01 with special features
       – Short Term Educational Experiences for Research (STEER) in the Environmental Health
         Sciences for Undergraduate and High School Students
       – Administrative Supplements for undergraduate and high school student participation in
         NIEHS-funded research projects.

   • Expand the role of clinicians in environmental health sciences
       – Institutional Patient-oriented career development programs in the environmental health
         sciences
       – DISCOVER Program

   • Improve and expand community-linked research/build a capacity to pursue
     research in global environmental health
       – Administrative supplements to NIEHS grants to support young investigators from
         developing countries
The Strategic Plan in Action


   • Foster the development of partnerships between the NIEHS and
     other NIH institutes, national and international research agencies, .
     . . . . to improve human health
      – Manufactured Nanomaterials: Physico-chemical Principles of Biocompatibility
        and Toxicity—joint program with NCI, NEI, NHGRI, NIGMS, NIDCR, NIOSH,
        and USEPA
      – Combating Autism Act: NIEHS will join with NIMH, NINDS, and other
        agencies to implement the provisions calling for an expansion of research on
        autism spectrum disorder including research on the cause, diagnosis or rule
        out, early detection, prevention, services, supports, intervention, and
        treatment.
Outstanding New Environmental
    Scientist (ONES) Award
Who does this program target?

  • Highly selective for most talented new scientists
  • Long term commitment to Environmental Health Sciences research
  • < 8 years postdoctoral experience
  • Assistant, Research Asst. Prof.
  • Evidence of independent productivity and facilities
  • No prior R01 support
  • Research oriented towards specific human disease/dysfunction/pathophysiologic
    condition or biological process and using environmentally relevant toxicants
What are the unique features?


   • Statement of Career Goals
   • Discussion of research experience and achievements
   • External Advisory Committee
   • Institutional Commitment to PI (minimum 80% research time)
   • Separate budget for equipment and career enhancement
Continue Development of Integrative Science

      •   Focus on human disease
      •   Integration of physician-scientists into the environmental health
          sciences
      •   Improved measures of exposures
      •   Using exposures as tools to understand underlying biology
New NIEHS Initiatives

   •   Interdisciplinary Partnerships in Environmental
       Health Sciences (R01/R21)


   •   Disease Investigation Through Specialized
       Clinically-Oriented Ventures in Environmental
       Research (DISCOVER--P50)
Interdisciplinary Partnerships: Vision

  • Foster scientific collaboration between clinical and basic investigators.
  • Accelerate the application of basic research results into the clinical
    setting.
  • Improve human health in those areas where environmental factors are
    known or expected to influence the development or progression of
    human disease.
Interdisciplinary Partnerships: Charge
 •   Focus on an environmentally influenced disease or dysfunction
 •   Support or establish a research partnership between basic and clinical
     investigators
 •   Create an interdisciplinary research approach that incorporates clinical
     and basic studies to address disease etiology, pathogenesis, susceptibility,
     progression and/or prognosis
DISCOVER Program: Vision


  •   Accelerate the application of knowledge derived from basic research
      into the clinical or public health setting with the goal of improving
      human health.


  •   Create opportunities to develop and apply novel approaches for the
      diagnosis, prognosis, prevention, and treatment/intervention of
      environmentally influenced diseases.
Discover Program: Charge

    • Develop an comprehensive theme that is based on a specific environmentally
      influenced disease or dysfunction.
    • Create an interdisciplinary research approach.
       – Incorporate clinical and basic mechanistic studies
       – Address disease etiology, pathogenesis, susceptibility, progression, and/or
         prognosis.
    • Develop research projects that individually are scientifically meritorious and
      together display a high degree of integration and synergy.
    • Develop a plan to facilitate knowledge transfer to clinical and/or public health
      practice.
Redirection of NIEHS
Institutional Training Grants/T32
Refocusing of institutional training programs/T32

 • Training for academic research
 • Multidisciplinary and Interdisciplinary Training
 • Integration of Basic, Clinical, Computational,
   Public Health research within programs
 • Focus on human biology and disease
 • Relevant environmental exposures to mission
   area
Looking Ahead . . . . . .
What’s in the future?

   • Initiatives in new research areas
      – Aging and the environment with the National Institute on Aging
      – Co-factors modifying disease trajectory with multiple institutes
      – Exposure sciences/personalized measures of exposure
      – Complex human diseases
          • Neurodegenerative diseases, reproductive disorders, chronic lung disease,
            specific cancers
      – Global environmental health—public/private partnerships
          • focus on a major problem that crosses borders and build capacity

   • Innovative funding mechanisms
      – Multiple PI awards
      – Linked awards—”fusion grants”
      – New career development mechanisms
www.niehs.nih.gov

Click on “Extramural Research Programs” for
        Funding Opportunities
        Program Officers and Contacts
        “What’s New”
        Access to Information on All Projects Funded by NIEHS

								
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