Slow Brain Oscillations of Sleep_ Resting State and Vigilance

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					Slow Brain Oscillations of Sleep, Resting State and Vigilance
Organized by the Netherlands Institute for Neuroscience (NIN), the VU University (VU),
the University of Amsterdam (UvA) and the Leiden University Medical Center (LUMC)

Tuesday June 29 – Friday July 2, 2010, official pre-FENS satellite

Venue: Trippenhuis, Royal Netherlands Academy of Arts and Sciences (KNAW)
Kloveniersburgwal 29, 1011 JC Amsterdam

Organizers: Eus Van Someren, Ysbrand van der Werf, Pieter Roelfsema, Huibert Mansvelder,
Fernando Lopes da Silva

Implementation: Tini Eikelboom, Wilma Verwey, Henk Stoffels (NIN)

The most important quest of cognitive neuroscience may be to unravel the mechanisms by which the
brain selects, links, consolidates and integrates new information into its neuronal network, while
preventing saturation to occur. During the last decade, neuroscientists working on the memory system
within several disciplines and in many labs over the world have observed an important involvement of
the specific types of brain oscillations that occur during sleep – the cortical slow oscillations; during
the resting state – the MRI default mode and other networks; and during task performance – the EEG
power and performance modulations. Understanding the role of these slow oscillations thus appear to
be essential for our fundamental understanding of the essentials of brain function. Never before has an
international meeting taken place that integrated these three fields of study and allowing for
Brain activity is characterized by oscillations; in spike frequency, field potentials or blood oxygen
level-dependent MRI signals. Environmental stimuli, reaching the brain through our senses, activate,
or inactivate, neuronal populations and modulate ongoing activity. In the absence of sensory input, as
is the case during rest or sleep, brain activity does not cease. Rather, its oscillations continue and
change with respect to their dominant frequencies and coupling topography. Studies ranging from the
molecular, physiological and behavioral to the cognitive level have in the past decade clearly indicated
that the study of these slow oscillations is essential for our understanding of plasticity, memory, brain
structure from synapse to default mode network, cognition, consciousness and ultimately for our
understanding of the mechanisms and functions of sleep and vigilance. At this 26th International
Summer School an international selection of the most renowned scientists advancing these fields will
present and discuss their work. The lectures will cover all levels of biological organization and are
targeted at Ph.D-students, postdoctoral fellows and senior researchers, both in basic and clinical
science, with an interest in plasticity, memory, sleep, vigilance, oscillations, default mode network
activity, cognition and consciousness.

Tuesday 29 June 2010
8:00    Registration
9:00    Eus Van Someren: welcome and overview

Themes and Speakers (bold) including published example paper on topic
I. Slow oscillations in detail and in perspective

9:15    Cellular and network mechanisms of recurrent cortical network activity
        Sanchez-Vives MV and McCormick DA (2000) Cellular and network mechanisms of
        rhythmic recurrent activity in neocortex. Nat Neurosci 3:1027-1034

10:00 Mechanisms of slow oscillations generation during sleep: neurons, glia and networks
      Amzica F and Massimini M (2002) Glial and neuronal interactions during slow wave and
      paroxysmal activities in the neocortex. Cerebr Cortex 12:1101-1113

10:45 Coffee break

11:15 Involvement of cytokines in slow wave sleep
      Krueger JM, Rector DM, Roy S, Van Dongen HP, Belenky G and Panksepp J (2008) Sleep as
      a fundamental property of neuronal assemblies. Nat Rev Neurosci 9:910-919.

12:00 Lunch

II. Sleep and resting state EEG-profile as heritable endophenotype and during development

13:15 Genetic determination of sleep EEG profiles in mice
      Maret S, Franken P, Dauvilliers Y, Ghyselinck NB, Chambon P and Tafti M (2005) Retinoic
      acid signaling affects cortical synchrony during sleep. Science 310:111-113.

14:00 Genetic determination of sleep EEG profiles in man
      Retey JV, Adam M, Honegger E, Khatami R, Luhmann UF, Jung HH, Berger W and Landolt
      HP (2005) A functional genetic variation of adenosine deaminase affects the duration and
      intensity of deep sleep in humans. PNAS 102:15676-15681.

14:45 Developmental aspects of slow oscillations during sleep
      Kurth S, Jenni OG, Riedner BA, Tononi G, Carskadon MA and Huber R (2009)
      Characteristics of sleep slow-waves in children and adolescents. Sleep in press

15:30 Tea break

III. Genetic, cellular and small scale network mechanisms of local use-dependent slow

16:00 Modulation of cortical neuronal activity by vigilance state, behavior and preceding sleep-
      wake history: cellular correlates of sleep homeostasis in freely behaving rats.
      Vyazovskiy VV, Cirelli C, Pfister-Genskow M, Faraguna U and Tononi G (2008) Molecular
      and electrophysiological evidence for net synaptic potentiation in wake and depression in
      sleep. Nat Neurosci 11:200-208.

16:45 Involvement of adenosine in slow wave sleep
      Halassa MM, Florian C, Fellin T, Munoz JR, Lee SY, Abel T, Haydon PG and Frank MG
      (2009) Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss.
      Neuron 61:213-219

18:00 Reception and buffet at the West-Indisch Huis
Wednesday 30 June 2010
IV. Phasic events during slow oscillations:

9:00    Impact of brainstem network activity on cortical dynamics during slow oscillations
        Mena-Segovia J, Sims HM, Magill PJ and Bolam JP (2008) Cholinergic brainstem neurons
        modulate cortical gamma activity during slow oscillations. J Physiol 586:2947-2960.

9:45    Grouping of spindle activity during slow oscillations in sleep
        Molle M, Marshall L, Gais S and Born J (2002) Grouping of spindle activity during slow
        oscillations in human non-rapid eye movement sleep. J Neurosci 22:10941-10947.

10:30 Coffee break

11:00 Spontaneous neural activity during human slow wave sleep
      Dang-Vu TT, Schabus M, Desseilles M ... and Maquet P. (2008) Spontaneous neural activity
      during human slow wave sleep. PNAS 105:15160-15165.

11:45 Lunch and poster session

V. Thalamocortical network interactions during slow sleep oscillations

13:15 Neuronal plasticity in thalamocortical networks during sleep and waking oscillations
      Steriade M and Timofeev I (2003) Neuronal plasticity in thalamocortical networks during
      sleep and waking oscillations. Neuron 37:563-576.

14:00 Thalamocortical mechanisms of slow oscillations
      Crunelli V, Blethyn KL, Cope DW, Hughes SW, Parri HR, Turner JP, Toth TI and Williams
      SR (2002) Novel neuronal and astrocytic mechanisms in thalamocortical loop dynamics.
      Philos Trans R Soc Lond B Biol Sci 357:1675-1693.

14:45 Tea break

VI. Cortico-hippocampal network interactions and replay during slow oscillations

15:15 The dynamics of memory reactivation and cortico-hippocampal interactions
      Johnson LA, Euston DR, Tatsuno M and McNaughton BL (in press). Stored-trace
      reactivation in rat prefrontal cortex is correlated with down-toup state transitions in neuronal
      ensemble activity. J Neurosci.

16:00 Coordinated memory replay in the visual cortex and hippocampus during sleep
      Ji D and Wilson MA (2007) Coordinated memory replay in the visual cortex and
      hippocampus during sleep. Nat Neurosci 10:100-107.

16:45 Communication between neocortex and hippocampus during sleep in rodents
      Sirota A, Csicsvari J, Buhl D and Buzsaki G (2003) Communication between neocortex and
      hippocampus during sleep in rodents. PNAS 100:2065-2069.

Thursday 1 July 2010
VII. Cortical synchronization and travelling of slow oscillations

9:00   Microvascular compliance changes across sleep and wake: mechanisms for
       local sleep regulation
       Rector DM, Schei JL, Van Dongen HP, Belenky G and Krueger JM (2009) Physiological
       markers of local sleep. The European journal of neuroscience 29:1771-1778.

9:45   Long range synchronization of up and down states
       Volgushev M, Chauvette S, Mukovski M and Timofeev I (2006) Precise long-range
       synchronization of activity and silence in neocortical neurons during slow-wave oscillations. J
       Neurosci 26:5665-5672

10:30 Coffee break

11:00 The sleep slow oscillation as a traveling wave
      Massimini M, Huber R, Ferrarelli F, Hill S and Tononi G (2004) The sleep slow oscillation as
      a traveling wave. J Neurosci 24:6862-6870.

11:45 Sources of slow oscillation travelling waves; overlap with the default mode network?
      Murphy, M., Riedner, B.A., Huber, R., Massimini, M., Ferrarelli, F. and Tononi, G. (2009)
      Source modeling sleep slow waves. PNAS, 106: 1608-1613.

12:30 Lunch and poster session

VIII. Functional benefits of slow oscillations during sleep

14:15 Mechanisms of sleep-dependent consolidation of cortical plasticity
      Aton SJ, Seibt J, Dumoulin M, Jha SK, Steinmetz N, Coleman T, Naidoo N and Frank MG
      (2009) Mechanisms of sleep-dependent consolidation of cortical plasticity. Neuron 61:454-

15:00 Sleep slow oscillations for memory consolidation
      Marshall L, Helgadottir H, Molle M and Born J (2006) Boosting slow oscillations during
      sleep potentiates memory. Nature 444:610-613.

15:45 Tea break

16:15 Sleep benefits subsequent hippocampal functioning
      Van Der Werf YD, Altena E, Schoonheim MM, Sanz-Arigita E, Vis JC, De Rijke W and Van
      Someren EJW (2009) Sleep benefits subsequent hippocampal functioning. Nat Neurosci

18:00 Dinner

Friday 2 July 2010
IX. What comes to mind

9:00   Resting state networks as seen via FMRI: Characteristics and interpretations
       Smith, SM, Fox PT, Miller KL, Glahn DC, Fox PM, Mackay CE, Filippini N, Watkins KE,
       Toro R, Laird AR and Beckmann CF (2009) Correspondence of the brain's functional
       architecture during activation and rest. PNAS 106:13040-13045.

9:45   Resting state default network oscillations interfacing vigilance and sleep
       Larson-Prior LJ, Zempel JM, Nolan TS, Prior FW, Snyder AZ and Raichle ME (2009)
       Cortical network functional connectivity in the descent to sleep. PNAS 106:4489-4494

10:30 Coffee break

11:00 Low frequency BOLD fluctuations during resting wakefulness and light sleep
      Horovitz SG, Fukunaga M, de Zwart JA, van Gelderen P, Fulton SC, Balkin TJ and Duyn JH
      (2007) Low frequency BOLD fluctuations during resting wakefulness and light sleep: A
      simultaneous EEG-fMRI study. Hum Brain Mapp

11:45 Lunch break and poster session

X. Slow oscilations in the competition between vigilant performance and resting state

13:15 Daydreaming your way out of coma? fMRI restings state studies in disorders of consciousness
      Boly M, Balteau E, Schnakers C, Degueldre C, Moonen G, Luxen A, Phillips C, Peigneux P,
      Maquet P and Laureys S (2007) Baseline brain activity fluctuations predict somatosensory
      perception in humans. PNAS 104:12187-12192.

14:00 Very slow EEG fluctuations predict the dynamics of stimulus detection
      Monto S, Palva S, Voipio J and Palva JM (2008) Very slow EEG fluctuations predict the
      dynamics of stimulus detection and oscillation amplitudes in humans. J Neurosci 28:8268-

14:45 Tea break

15:15 Infraslow oscillations in drowsy performance and EEG
      Huang, R.-S., Jung, T.-P., Delorme, A. & Makeig, S. Tonic and phasic
      electroencephalographic dynamics during continuous compensatory tracking. NeuroImage 39,
      1896–1909 (2008).

16:00 Closing and drinks


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