THE UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER DEPARTMENT OF BIOCHEMISTRY & MOLECULAR BIOLOGY T HE SDS PAGE Volume 4, Issue 3 September 1, 2004 Check it out on-line! http://w3.ouhsc.edu/biochem PUBLICATIONS Sanjay Bidichandani, Ph.D., was selected as Course Director for Clinical Molecular Genetics for the Mid-America Genetics Education Li, G. and Zhang, X. C. (2004) GTP hydrolysis mechanism of Consortium [MAGEC] (University of Oklahoma, University of Arkansas, Ras-like GTPases. J. Mol. Biol. 340: 921-932. I N V I of Kansas, R E S E N T A T I O N S University T E D P and University of Nebraska). Ceres, P., Stray, S.J., and Zlotnick, A. (2004) Hepatitis B virus capsid assembly is enhanced by naturally occurring mutation F97L. J Virol. 78: POSTER PRESENTATIONS 9538-9543. Jialing Lin, Ph.D., presented a poster entitled “The interface of Stray, S.J., Ceres, P., and Zlotnick, A. (2004) Zinc ions trigger BcI-2 homodimer is distinct yet overlapping with that of BcI-2/Bax conformational change and oligomerization of hepatitis B virus heterodimer” at the 10th SCBA International Symposium, Beijing, capsid protein. Biochemistry 43: 9989-9998. July 18-23. van den Berg, T.K., Honing, H., Franke, N., van Remoortere, A., Schi- Wei-Xing Guo, Quentin N. Pye, Kelly S. Williamson, Charles A. phorst, W.E.C.M., Liu, F. - T., Deelder, A.M., Cummings, R.D., Hokke, Stewart, Kenneth L. Hensley, Yashige Kotake, Robert A. Floyd, and C.H., and van Die, I. (2004) LacdiNAc-glycans constitute a parasite Robert H. Broyles presented a poster entitled “Disruption of pattern for galectin-3-mediated immune recognition. Mitochondrial Membrane Potential by Choline Deficiency in J. Immunol. 173(3): 1902-1907. Cultured CWSV-1 Rat Hepatocytes” at the 95th Annual Meeting of Nyame, A.K., Kawar, Z.S. and Cummings, R.D. (2004) Antigenic the American Association for Cancer Research, March 27-31, 2004, glycans in parasitic infections: implications for vaccines and Orlando, FL. diagnostics. Arch. Biochem. Biophys. 426(2): 182-200. Robert H. Broyles, Visar Belegu, Austin Roth, Katharine Harris, Otto, V.I., Schϋrpf, T., Folkers, G., and Cummings, R.D. (2004) Charles Stewart, Quentin Pye, Biji Kurien, Klodianna Jani, and Sialylated complex-type N-glycans enhance the signaling activity of Marie Trudel presented a poster entitled “A Phenotypic Cure for soluble intercellular adhesion molecule-1 in mouse astrocytes. J. Biol. Sickle Cell Disease: A Proposal and Progress” at the 15th NIH Chem. 279(34): 35201-35209. Conference on Hemoglobin Switching, September 10-14 2004, Yan, Q., Kamura, T., Cai, Y., Jin, J., Ivan, M., Mushegian, A., Conaway, Orcas Island, WA. R.C., and Conaway J.W. (2004) Identification of elongin C and Skp1 Robert H. Broyles, Visar Belegu, Charles A. Stewart, Quentin N. sequences that determine cullin selection. J. Biol. Chem., published on Pye, Austin C. Roth, Kenneth L. Hensley, and Robert A. Floyd line July 2004 as 10.1074/jbc.M408018200. presented a poster entitled “Targeting Transcription in Stem Tlapak-Simmons, V.L., Baron, C.A., and Weigel, P.H. (2004) Cells:Ferritin Heavy Chain May Be Useful in Gene Therapy and Characterization of the purified hyaluronan synthase from Iron Chelation Therapy for Parkinson’s and Other Diseases” at the Streptococcus equisimilis. Biochemistry 43(28): 9234-9242. 2nd annual meeting of the International Society for Stem Cell Harris, E.N., Weigel, J.A., and Weigel, P.H. (2004) Endocytic function, Research, June 10-13, 2004, Boston, MA. glycosaminoglycan specificity, and antibody sensitivity of the Caleb Stowell presented a poster at the SURE program this recombinant human 190-kDa hyaluronan receptor for endocytosis summer entitled “Investigations into the structure and function of (HARE). J. Biol Chem. 279(35): 36201-36209. T-synthase, an enzyme responsible for mucin glycosylation” by Caleb Stowell, Tongzhong Ju, Kiem Nguyen, Ziad Kawar, and KUDOS Richard Cummings. Richard Cummings, Ph.D., served as a regular member of the NIH Physiological Chemistry Study Section, which met in June 2004 at the NIH in Bethesda, MD. NEW GRANTS Richard Cummings, Ph.D., is the new Chair of the Graduate Paul Weigel, Ph.D., was awarded a new NIH grant. Education and Curriculum Committee (GECC) of the General Program 1 RO1 GM069961-01A1 - Structure-Function of the HA Receptor for in Biomedical Sciences (GPiBS). He replaces Dr. Anne Pereira of the Endocytosis. 7/1/04-6/30/07, Total Direct: $800,000 Department of Pathology. Sanjay Bidichandani, Ph.D., was appointed as a member of the GPiBS student recruitment committee. Sanjay Bidichandani, Ph.D., was appointed as a member of the OU College of Medicine, Student Promotion committee. PAGE 2 THE SDS PAGE INVITED PRESENTATIONS Richard Cummings, Ph.D., was invited to present a lecture at The Institute of Microbiology, Chinese Academy of Science, Beijing, China on July 8th, 2004. Richard Cummings, Ph.D., was invited to present a lecture for the Department of Biochemistry & Molecular Biology at the Qindao University Medical School, Shandong Province, China on July 13, 2004. Richard Cummings, Ph.D., was invited to speak at the 8th Symposium on Complex Carbohydrate in China, 2004, Shanghai, China on July 17, 2004. Richard Cummings, Ph.D., was invited to present a lecture for the Department of Biochemistry & Molecular Biology at the SuZhou University Medical School, Jiangsu province, China on July 20, 2004. Tongzhong Ju, Ph.D., was invited to present at lecture for the Department of Biochemistry & Molecular Biology at the Qindao University Medical School, Shandong Province, China on July 13, 2004. Tongzhong Ju, Ph.D., was invited to speak at the 8th Symposium on Complex Carbohydrate in China, Shanghai China on July 17, 2004. Tongzhong Ju, Ph.D., was invited to present a lecture for the Department of Biochemistry & Molecular Biology at the SuZhou University Medical School, Jiangsu province, China on July 20th, 2004. Jialing Lin, Ph.D., was invited to speak at the Institute of Botany, Chinese Academy of Sciences, Beijing on July 6th, 2004. Jialing Lin, Ph.D., was invited to speak at the College of Life Sciences, Peking University, Beijing on July 7, 2004. Jialing Lin, Ph.D., was invited to speak for the Department of Medical Technology/Institute of Cell & Molecular Biology at Taipei Medical University, Taipei on July 9, 2004. Jialing Lin, Ph.D., was invited to present “Mapping the dimer interface of BcI-2 family proteins — Implication for apoptotic regulation and drug design” for the Department Biology at Hong Kong University of Science and Technology on July 14. Adam Zlotnick, Ph.D., was invited to present “Describing Assembly of Nanoparticles with Minimal Thermodynamic—Kinetic Models” at the 1st Annual Viruses and Protei Cages as Materials Conference on August 1-3, 2004. C. Pfeiffer, J.M. Johnson, and A. Zlotnick were invited to present “Thermodynamic and Kinetic Control of Assembly of lcosahedral Structures” at the 1st Annual Viruses and Protei Cages as Materials Conference on August 1-3, 2004. C. Pfeiffer, J.M. Johnson, and A. Zlotnick were invited to present “dsDNA is a Nucleating Agent in the Production of Nanotubes Derived from CCMV Capsid Protein” at the 1st Annual Viruses and Protei Cages as Materials Conference on August 1-3, 2004. Congratulations Jun Peng Pablo Ceres Helga Veeraprame For completing your MS Thesis Defenses. PAGE 3 THE SDS PAGE — FA R E W E L L A N D T H A N K S — Joyce Anderson We would like to say congratulations and farewell to Joyce Anderson who retired from our department June 30, 2004. Joyce was a very valuable member of the Department of Biochemistry and Molecular Biology for over 17 years. She started at OUHSC in September of 1986 as a Secretary. She worked her way up and became the Department's Business Manager in March of 1993. Joyce did an excellent job in that role while working under two different Chairmen. She leaves us in good shape as she now devotes her time and energy to herself and her family. We say thank you to Joyce for all the hard work and time she gave to us. She will be greatly missed. September Birthdays September 1 - Naoka Komori September 2 - James Hocker September 2 - Hanke Van der Wel September 4 - Bruce Baggenstoss September 12 - Karla Rodgers September 13 - Shelly Gulati September 13 - Sabrina Pitts September 15 - Gillian Air September 15 - Leonard Oatman September 16 - Tony Bao September 18 - Kellie Williams September 22 - Bhalaajee Meenakshi-Sundaram September 24 - Irene DeBiase September 27 - Carole Anne Davis September 28 - Negar Rahman (Ruby) September 29 - Olga Nikolaeva PAGE 4 —GPIBS VISITS BIOCHEMISTRY — THE SDS PAGE The Department of Biochemistry & Molecular Biology hosted a luncheon and tour of the Department’s research programs on August 17, 2004 for the GPIBS Students. These hosts included Gillian Air, Ph.D., Edith Kinney Gaylord Presidential Professor, Sanjay Bidichandani, M.B.B.S., Ph.D., Assistant Professor, Paul DeAngelis, Ph.D., Associate Professor, Karla Rodgers, Ph.D., Assistant Professor, and Tim Mather, Ph.D., Adjunct Assistant Professor. The student ushers were Tasha Arnett, Rhonda Clark, Paul Rindler, Pablo Ceres, Mandy Peak, Laura Hern, Craig Eyster, and Breca Tracy. PAGE 5 THE SDS PAGE Welcome to Our New Students! PhD Students Anthony Luyai Jun Peng Bojing Shao Zhuo Wang MS Student Shuying Zhao 歡迎 歡迎 歡迎 歡迎 歡迎 Thanks to the Welcoming Committee Laura Hern (Chair), Jun Peng, Kellie Williams, and Mandy Peak comprised a welcoming committee that coordinated pick-up and transportation of new students from the airport to their apartments, purchased survival items for students’ first few days in the United States, made up students’ beds, accompanied students to the Social Security Office, and provided general information on Oklahoma City and our campus. We appreciate the efforts of the welcoming committee members as well as those of Jian Liu and Feng Li, who also helped out, in making the arrival of our new students a positive and welcoming experience.