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Neuroscience
Asset Map Ac t i vi ti e s, Stre n g t h s an d
Opportunities
Neuroscience Asset M ap 3
4 Execu tive Su mmar y
4 K e y E l e m e n t s o f B. C .’s N e u ro s c i e n ce A s s e t s
5 O ppo r tunities for Collaboration
6 I nt ro d u c t i o n
7 Neuroscience Research
8 Fu n d i n g f o r N e u ro s c i e n ce R e s e a rc h
9 Fo c u s o f N e u ro s c i e n ce R e s e a rc h
9 Ty p e o f N e u ro s c i e n ce R e s e a rc h
9 B a s i c a n d M u l t i p l e R e s e a rc h
10 Clinical Studies
11 Translational Stud ies
11 Targeted D iseases and Conditions
13 Pe r s o n n e l I n vo l ve d i n N e u ro s c i e n ce R e s e a rc h
13 K e y R e s e a rc h e r s
15 Net wo r ks
15 Suppo r t Facilities
16 Bio Banks
17 Co n t ra c t R e s e a rc h w i t h B. C .’s N e u ro s c i e n ce R e s e a rc h e r s
18 Techno logy Transfer Activit y from B.C.’s Neuroscientists
19 B.C. Companies Involved in Neuroscience
20 O p p o r t u n i t i e s fo r Co l l a b o rat i o n
21 Contac ts
21 Ack nowledgements
22 Ap p e n d i x 1 . B.C. D epar tments and O ther Centres Involved in Neuroscience
24 R e s e a rc h
39 Ap p e n d i x 2 . N e u ro s c i e n ce R e s e a rc h e r s i n B. C . I n c l u d e d i n t h e A n a l y s i s
40 Ap p e n d i x 3 . B. C .’s Ca n a d a R e s e a rc h C h a i r s I n vo l ve d i n N e u ro s c i e n ce R e s e a rc h
4 B rit ish Columbi a
E x ecu tiv e Summ ary
The Province of British Columbia is an important and dynamic centre for neuroscience research.
Active areas of research include: functional studies of the nervous system, neurodegeneration,
learning and behaviour, stroke, trauma, mental illness, sensory conditions and pain. Investigators are
using genetics, genomics, proteomics, bioinformatics, imaging, psychology and other techniques to
develop a better understanding of the nervous system. In addition, companies have been established
in B.C. on the basis of local research findings and expertise in neuroscience. This report focuses on
the province’s researchers at the B.C. Cancer Agency (BCCA), the Universities of British Columbia,
Northern British Columbia, Simon Fraser and Victoria and B.C. companies that are working in
neuroscience.
Key Element s of B .C .’s Neurosc ience A sset s
S cie ntific
• There are over 340 senior researchers working in neuroscience research, including 33 Canada
Research Chairs1 and eight other endowed Chairs.
• Home to two prominent large scale multidisciplinary neuroscience research organizations: The
Brain Research Centre and ICORD (International Collaboration on Repair Discoveries)
• Fourteen biobanks containing ethically collected tissues, blood, images, and/or DNA from
patients with Alzheimer’s, Parkinson’s and Huntington’s diseases; amyotrophic lateral sclerosis;
dementia; epilepsy; multiple sclerosis (MS); stroke; neuromuscular diseases; cancer; as well as an
eye bank and a spinal cord injury (SCI) registry.
• Funding totaling over $345M2 over the past five years (between 2001/2002 and 2005/2006) for
more than 2,330 projects/ awards3.
• Important centre for MS clinical trials and home to a province-wide tertiary MS clinic, the
second largest in North America, with over 4,500 registered patients.
• Internationally recognized clinical, basic and social science research programs on Alzheimer’s
disease and related dementias, with over 1,200 patients seen each year.
• Major research and clinical expertise in Parkinson’s and other movement disorders by the
province-wide Movement Disorders Clinic that tracks up to 2,500 patients annually.
• Significant research on SCI, including basic, translational, clinical and social.
• Significant expertise in imaging (almost $47M in funding over the last five years) and genetics/
genomics (particularly developmental delays and genetic basis of brain diseases).
• Continuing recruitment of world-class neuroscientists to the province.
• Contracts or agreements worth $54M between B.C.’s neuroscientists and 138 companies,
including 17 of the world’s top 20 pharmaceutical companies.
1 High level endowed research professorships created by the Canadian Government.
2 All $ figures refer to Canadian $.
3 We use the term projects/awards as many individual projects receive funding from more than one source. The actual number of
distinct neuroscience research projects is less than 2,330.
Neuroscience Asset M ap 5
Left: Researchers using confocal
microscopy to assess cell death.
Business
• B.C. research has resulted in at least 79 U.S. patents, an additional 50 Patent Cooperation Treaty
(PCT) applications and 31 technologies licensed to at least 22 different companies.
• The province’s inventions have formed the basis for eight of its 14 neuroscience companies.
• One company, Neuromed Pharmaceuticals Inc., signed Canada’s largest research collaboration
and license agreement with Merck & Co. in March 2006, worth up to $450M.
• At least four spin-off companies have been purchased by other companies for nearly $100M.
• Companies span the stage of development spectrum with two (14 per cent) having marketed or
approved products or services, five (36 per cent) still involved in early research or development,
and seven (50 per cent) undertaking clinical trials.
• Twelve (86 per cent) companies are developing therapeutics, while diagnostics and reagents are
each being developed by a single company (7 per cent).
• The most common disease focus is Alzheimer’s or other aspects of impaired cognition (four
companies, 29 per cent) and pain (three companies, 21 per cent).
Oppor tunit ies f or Coll ab orat ion
The excellence and successes of our researchers, coupled with infrastructure and corporate
innovations offers numerous opportunities to potential partners. Specifically, there are opportunities
for those who can effectively translate research findings to the bedside; those who have medicinal
chemistry, drug synthesis, pharmacokinetics, formulation development, GMP manufacture and/or
toxicology facilities; and partners interested in developing additional subject/patient registries and
health information databases. Furthermore, given the large number of B.C. patients who consent to
enter clinical trials and the wealth of patient data associated with our registries and biobanks, there
are opportunities to work with more companies on their clinical compounds.
In addition, although B.C. is home to three Biosafety Containment Level 3 [BSCL3] facilities there
is interest in working with other such facilities (particularly BSCL4), or with researchers wanting to
do collaborations making use of our BSCL facilities.
6 B rit ish Columbi a
I n troduction
The nervous system, consisting of the brain, spinal cord, peripheral nervous system, and sensory
organs (eyes, ears, organs of taste and smell, other receptors) is highly complex. Its numerous
disorders affect a large part of the population and are frequently severe and debilitating. These
disorders include degenerative conditions, for example: multiple sclerosis (MS), macular
degeneration, Parkinson’s, Alzheimer’s and Huntington’s diseases; chronic diseases such as epilepsy
and migraine; psychiatric disorders comprising anxiety, bipolar disorder, depression, schizophrenia
and others; congenital disorders such as cerebral palsy and spina bifida; and other conditions (e.g.,
learning and behavioural disorders, sleeplessness, chronic pain, stroke, spinal cord and other injuries,
infection and brain cancer).
Many neurological conditions are currently untreatable or poorly managed, particularly as the
delivery of drugs to the central nervous system (CNS) can be a challenge due to the presence of the
blood-brain barrier. Although over U.S. $50 billion is spent annually on CNS prescription drugs
worldwide (IMS Health), most treat only the symptoms rather than the cause. Furthermore, many
neurological diseases are becoming more common as the population ages.
The degree of unmet need in the management of neurological conditions makes this a challenging
and worthwhile area for research. In addition, knowledge of the neural basis of human behaviour
and learning is essential for understanding our perception of and interaction with the external world.
Such increased awareness should help to alleviate problems associated with social marginalization,
substance abuse, aggression and learning disorders. Scientists in British Columbia (B.C.) are using
genetics, genomics, proteomics, bioinformatics, imaging, psychological and social science research
techniques and other technologies to develop a better understanding of the nervous system.
Furthermore, companies have been established in B.C. on the basis of local research findings and
expertise in neuroscience. The following outlines the strengths, challenges and opportunities in all
aspects of neuroscience research in B.C., as well as industrial activity in this field.
Top: Scan of
human brain
showing the
corpus callosum
connecting the
hemispheres.
Right: The scars
of MS are revealed
by MRI imaging.
Neuroscience Asset M ap 7
Neurosci ence Rese arch
B.C. is home to a number of world renowned neuroscientists. Four of the provinces universities (British
Columbia [UBC], Northern British Columbia [UNBC], Victoria [UVic], Simon Fraser [SFU]) and
the B.C. Cancer Agency (BCCA) are undertaking a significant amount of neuroscience research. This
work is being undertaken on campus, at Vancouver-based hospitals or at specific research centres (Table
1 and Appendix 1). Of particular importance are the Brain Research Centre and ICORD (International
Collaboration on Repair Discoveries), organizations that link hundreds of researchers to facilitate
multidisciplinary research.
Table 1
Neuroscience Research Centres in B.C.
Institution Description
Brain Research Centre, UBC A partnership between the Vancouver Coastal Health Research
(www.brain.ubc.ca) Institute (VCHRI) and the Faculty of Medicine at UBC. Encourages
and facilitates interdisciplinary research and builds bridges
between basic, translational, clinical, social, and industrial
investigators. Links more than 175 investigators affiliated with
UBC, SFU, UVic, UNBC, VCHRI, and all major teaching hospitals and
neuroscience clinics in Vancouver.
B.C. Centre for Stroke and Cerebrovascular Located at Vancouver General Hospital (VGH), the centre takes a
Diseases (www.bcstrokecentre.ca) multidisciplinary approach to stroke care, research and education.
Centre for Molecular Medicine and Conducts research on genetic susceptibility to disease, particularly
Therapeutics (www.cmmt.ubc.ca) those involving the central nervous system.
Centre for Research on Personhood in Interdisciplinary research centre that explores the social,
Dementia (www.crpd.ubc.ca) psychological and lifestyle influences on the dementia experience
in order to find ways to improve quality of life for persons with
dementia and their families.
ICORD An interdisciplinary, collaborative research and training
(International Collaboration on Repair environment for the development and translation of more
Discoveries) effective strategies to promote functional recovery and improved
(www.icord.org) quality of life after spinal cord injury. Links more than 300
researchers from B.C.’s four main universities, VCHRI, B.C. Institute of
Technology and Neil Squire Society.
Institute of Mental Health, UBC Community of scientists and clinicians who examine issues related
to mental health and mental illness and seek new insights into
diagnosis and treatment.
Pacific Parkinson’s Research Centre (PPRC), Dedicated to research and treatment of Parkinson’s Disease, with
UBC (www.parkinsons.ubc.ca) a particular focus on functional imaging with positron emission
tomography (PET). It has a provincial, national, and international
role in movement disorders, clinical trials, PET, and laboratory
research.
Movement Disorders Clinic, UBC A component of the PPRC, this tertiary treatment centre provides
assessment, diagnosis, treatment and counseling to patients with
Parkinson’s disease and other movement disorders and training to
clinical fellows and medical students.
Prionet Canada A Canadian Network of Centres of Excellence for research
(www.prionetcanada.ca) headquartered at UBC. Focuses on prion disease problems posed
by Bovine Spongiform Encephalopathy (BSE), chronic wasting
disease (CWD) and Creutzfeldt-Jakob disease (CJD).
8 B rit ish Columbi a
Fund i ng f o r Neu r o s c i enc e Re s e a r c h
Over 340 senior researchers are working on aspects of neuroscience in B.C. (Appendix 2). Over
the past five years, these researchers have managed over 2,330 projects/awards4 totaling more than
$345M 5. The research groups are spread among 71 university departments, research centres and
hospital groups (Appendix 1).
Research funds come from multiple sources. Over the past five years, Canadian federal and provincial
governments have supported B.C. neuroscientists with over $213M (61 per cent of the total), while
companies have supplied approximately $54M, generally in the form of contract research (Figure
1). The majority (95 per cent) of the $12.4M US government funding was provided by the National
Institutes of Health (NIH).
Figure 1
Funding for
Neuroscience
Research
(Total $345M
for 2,330
61%
Projects/Awards)
19%
16%
4%
$M 0 10 20 30 40 50 60 70
Figure 2
Canadian Institutes of Health Research (Federal) 65.6
Major B.C. Knowledge Development Fund (Provincial) 42.2
Neuroscience
Canada Foundation for Innovation (Federal) 37.8
Funders
Michael Smith Foundation for Health Research (Provincial) 19.5
Canada Research Chairs (Federal) 13.8
Natural Sciences and Engineering Research Council of Canada (Federal) 11.8
National Institutes of Health (US government) 11.1
B.C. Ministry of Children and Family Development (Provincial) 7.5
Seven different organizations provided 93 per cent of the Canadian government’s funding for
neuroscience (Figure 2). These and other funds were competitively awarded following national and/
or international peer-review. The three key research organizations, responsible for 42 per cent of all
funding, were the Canadian Institutes of Health Research (CIHR) (Canada’s equivalent of the U.K.’s
Medical Research Council or the U.S. NIH), the Canada Foundation for Innovation (CFI) and the
B.C. Knowledge Development Fund. In addition, Genome B.C./Canada made multi-million dollar
awards for major projects (see below).
4 We use the term projects/awards as many individual projects receive funding from more than one source. The actual number of
distinct neuroscience research projects is less than 2,330.
5 All $ figures refer to Canadian $.
Neuroscience Asset M ap 9
Fo cus of Neurosc ience Rese arc h
Neuroscience encompasses a whole range of conditions and disciplines, ranging from basic research
into brain genetics to the learning of languages. Between 2001/2002 and 2005/2006, 33 per cent
of our neuroscience funding was spent on fundamental research of the brain, including CNS
development, neuroendocrinology and genetics, while learning/behaviour6 and neurodegeneration7
each accounted for 18 per cent of the research funding (Figure 3)8. Details on specific conditions
within these neuroscience categories are provided below. It should be noted that B.C. also has an
impressive community of researchers working on assistive devices for patients with spinal cord injury
(SCI) and other neurological conditions. This research is outside the scope of the current Asset Map.
$M 0 20 40 60 80 100 120 140
Figure 3 Functional/basic CNS studies 114.6
Funding for Learning/behaviour 62.8
Different
Neurodegeneration 60.9
Categories of
Neuroscience Trauma 54.8
(Total $345M) Psychiatric illness 31.4
Sensory 16.9
Other 3.7
Ty pe of Neurosc ienc e Rese a r c h
B a sic and Multiple Research
Fifty two per cent ($182M) of our total funding over the past five years has been dedicated to
basic research. An additional 22 per cent of funding ($74.9M) was spent on research facilities and
projects that had multiple applications, including, for example, a basic understanding of neurological
conditions, their treatments, clinical and/or translational studies (Figure 4).
Figure 4
Epidemiological 2%
Type of Translational 2%
Neuroscience
Research
Conducted between
2001/2 and Basic 52%
2005/6
Multiple 22%
(Total $345M
for 2,330
Projects/Awards) Clinical 14%
Social 8%
6 Includes research related to cognition, social and emotional development, memory, language, aggression, suicide, autism, dyslexia,
fetal alcohol syndrome, and attention-deficit hyperactivity disorder.
7 Includes Parkinson’s, Huntington’s, Alzheimer’s, prion diseases; amyotrophic lateral sclerosis (ALS); MS.
8 Trauma includes brain and spinal cord injury, stroke; psychiatric illness includes depression, bipolar disorder, schizophrenia,
anxiety, substance abuse, psychosis, eating disorders; sensory includes visual, auditory, and olfactory conditions.
10 B rit ish Columbi a
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
Figure 5
Neurosciences Genetics/
genomics
Funding for (Total $35M)
Genetics and
32.2 0.3 2.4
Imaging
Imaging
(Total $46.9M)
16.5 15.9 14.6
Epidemiologic Basic Clinical Multiple
Genetics/genomics is a particularly important area of basic research. Eighteen per cent of basic
research funding (10 per cent of total funding) was dedicated to better understanding the genetic
basis of psychiatric, neurodegenerative, behavioural and sensory disorders (Figure 5). This included
major projects funded by Genome B.C./Canada9. Imaging is also important to our research,
accounting for 14 per cent of total neuroscience funding and nine per cent of basic research funding
between 2001/2002 and 2005/2006 (Figure 5). In addition, we have an active stem cell research
community10 and a major interest in aging research.
Clinical Studies
With its unique province-wide patient management system, B.C. is a magnet for clinical trials in
neurological disorders. Over $48M has been obtained for such trials over the past five years, with 36
per cent of that spent on MS (Figure 6). The province is home to a major MS Magnetic Resonance
Imaging facility (www.msmri.com) as well as the second largest tertiary MS clinic in North America,
with over 4,500 registered patients.
$M 0 2 4 6 8 10 12 14 16 18 20
Figure 6 Multiple sclerosis 17.3
Funding for Substance abuse 8.2
Neuroscience
Parkinson's/other movement 4.4
Clinical Studies
Stroke 4.1
(Total $48.3M)*
Bipolar 3.9
Cancer 1.8
Depression/other mood disorders 1.6
Alzheimer's/other dementias 1.5
* Includes ‘other’ clinical studies amounting to $5.5 M
The high level of clinical trials funding for Parkinson’s and other movement disorders reflects the
importance of the Movement Disorders Clinic, a province-wide tertiary treatment centre that
9 Completed: “A Quantitative and Comprehensive Atlas of Gene Expression in Mouse Development” ($13.2M). In progress:
“Genomic Tools for Diagnosis and Evaluation of Mental Retardation” ($5.6M); “Pleiades Promoter Project” ($10.1M). See www.
genomebc.ca for information on these projects.
10 See the Regenerative Medicine Asset Map for more information on our stem cell research.
Neuroscience Asset M ap 11
provides assessment, diagnosis, treatment and counseling to patients with such conditions. Each
year, this Clinic follows approximately 1,100 patients with typical Parkinson’s disease, 400 patients
with Parkinson-like disorders and 500 – 1,000 dystonia patients. The Clinic is one component
of the acclaimed Pacific Parkinson’s Research Centre. Our other major tertiary care clinic for
neurodegenerative disease, the Clinic for Alzheimer’s Disease and Related Disorders, provides clinical
service and state-of-the-art research including biomarker development, neuroimaging and clinical
trials. Over 1,200 patients are seen annually11. The social aspects of dementia are targeted by the
Centre for Research on Personhood in Dementia.
The province is also an important participant in clinical trials for mood disorders, with $5.5M of
funding received over the last five years for bipolar, depression and other mood disorders. The UBC
Mood Disorders Clinic follows approximately 400 patients with bipolar disorder a year. In addition,
stroke research receives an impressive amount of funds due to the well established Centre for Stroke
and Cerebrovascular Diseases with its 24/7 acute stroke service. Vancouver also provides tertiary care
to a large number of patients with SCI and ICORD is strong in the development and validation of
outcome assessments for such people.
Since many patients in B.C. consent to enter clinical trials, there are opportunities for more
companies on both their early (Phases I and II) and later stage clinical compounds.
Transl ational Studies
$5.4M in funding was involved in translational or drug discovery/development activities (Figure
7), including gene therapy and testing new therapies such as those involving stem cells. Our main
disease target in this field was Huntington’s disease, followed by SCI and stroke. “Multiple” research
included stem cell therapy for a number of different diseases and funding for a laboratory dedicated
to experimental therapeutics in animal models of human diseases. An additional $0.5M was spent on
basic research for gene therapy.
We would like to increase our translational research by collaborating with investigators with expertise
in this area.
Figure 7
Funding for
Translational
Multiple 31%
Research
Huntington’s 31%
(Total $5.4M) Parkinson’s 4%
Cancer 3%
Other 7%
Blood-brain barrier 4%
Spinal Cord Injury 10%
Stroke 10%
Targeted Di se ase s a nd Co nd it io ns
B.C.’s researchers are studying numerous diseases and conditions of the nervous system, with those
receiving the most focus shown in Figure 8. Thirteen per cent of total funding was dedicated to SCI,
due to the establishment and operations of B.C.’s ICORD research. Studies on SCI included basic,
11 An associated research facility, the Kinsmen Laboratory of Neurological Research at UBC Hospital (www.interchg.ubc.
ca/mcgeerpl), received an additional $3.5M grant from the provincial government through the Pacific Alzheimer Research
Foundation (www.parf.ca) in May 2006.
12 B rit ish Columbi a
translational, clinical and social research, with the majority of funding dedicated to more than one
of these components (categorized as “multiple”12 and incorporating the approximately $33M in
construction costs for the $45M research centre).
$M 0 5 10 15 20 25 30 35 40 45 50
Figure 8 Spinal cord injury 43.3
Funding by Multiple sclerosis 24.6
neurological Parkinson’s / other movement 17.1
disorder Substance abuse 13.7
2001/02 to Huntington’s 7.7
2005/06 Stroke 7.3
Depression/bipolar / other mood 7.2
(Total $48.3M)
Schizophrenia / other psychosis 6.3
Alzheimer’s / other dementias 5.8
Pain 4.5
Other CNS injury 3.9
MS was the second most important disease area. In this case, the majority of studies were clinical,
reflecting the MS clinic’s status as the second largest in North America (Figures 9 and 10). Substance
abuse and Parkinson’s disease also received significant funding (Figures 11 and 12). Again, clinical
research was a major component in the study of these conditions.
Figure 9
Spinal Cord
Injury Funding by
Research Type
Multiple 81%
(Total $43.3M)
Basic 14%
Clinical 3%
Social 1%
Transitional 1%
Figure 10
Multiple Sclerosis
Funding by
Research Type
(Total $24.6M)
Clinical 70%
Multiple 23%
Basic 7%
12 The new ICORD research centre will be used for basic, translational, clinical, and social research hence its funding is categorized
as “multiple”.
Neuroscience Asset M ap 13
Figure 11
Substance Abuse
Funding by
Research Type
(Total $13.7M)
Clinical 60%
Basic 28%
Social 11%
Epidemiological 1%
Figure 12
Funding for
Parkinson’s and
Other Movement
Disorders by
Basic 50%
Research Type
Clinical 26%
(Total $17.1M)
Translational 2%
Epidemiologic 2%
Multiple 15%
Social 5%
Personnel Involved in Neurosc ience Rese arc h
Due to the multiple activities undertaken by staff, total staffing in neuroscience research is unavailable.
However, the Brain Research Centre alone identifies over 200 members (56 senior investigators, 137
other investigators and numerous scientific and administrative support staff ), while ICORD lists
54 Principal Investigators and 225 trainees. Furthermore, between 2002 and 2005, 23 PhD and 26
MSc students graduated from the UBC Graduate Program in Neuroscience (www.interchange.ubc.
ca/neurosci/program.htm), which involves 60 faculty members representing 13 departments from the
Faculties of Medicine, Science, and Arts. An additional 1,363 MSc and 1,370 PhD students were still
enrolled in UBC departments (Appendix 1) involved in neuroscience research in 2005.
Key Rese arc hers
B.C. is fortunate to have a number of prize-winning researchers within its neuroscience research
teams and we continue to attract world-class researchers to the province13. Thirteen investigators
have achieved funding levels of $6M or more over the past five years and six have received over $10M
(Table 2). In addition, 33 of our neuroscientists are Canada Research Chairs (CRC) (Appendix 3)14
and at least eight others also hold endowed Chairs.15
13 For example, in 2005, Canada Research Chair Neil Cashman, a Jonas Salk Prize winner for lifetime achievement in biomedical
research, joined UBC from the University of Toronto to head the Vancouver Coastal Health ALS Centre and PrioNet; Allan H
Young, was recruited from the University of Newcastle upon Tyne as Leading Edge Endowment Fund (LEEF) Leadership Chair
in Depression Research and Associate Director of the UBC Institute of Mental Health.
14 Canada Research Chairs are high level endowed research professorships created by the Canadian Government to attract and retain
some of the world’s most accomplished and promising minds.
14 B rit ish Columbi a
15
Table 2
Scientists Obtaining More than $10M in Funding for Neuroscience Research in the Past Five Years
Researcher Research Focus and Awards
Cynader, Max, PhD, FRSC Research focused on understanding the nature of the processing performed by
Director of the Brain Research Centre; Professor of the cerebral cortex, especially the sensory cortices dealing with vision and audition
Ophthalmology, UBC and on the neural and molecular mechanisms underlying the development and
(www.brain.ubc.ca/Dr.MaxCynader.php) adaptability of the cortex. CRC; Fellow of The Royal Society of Canada; Fellow of the
Canadian Academy of Health Sciences; Bank of Montreal Fellow of The Canadian
Institute for Advanced Research (CIAR); 1995 Gold Medal in Health Sciences,
Science Council of B.C.; past president of Canadian Association for Neuroscience.
A scientific founder of NeuroVir (purchased by MediGene); a co-founder of
Wavemakers Research (purchased by Harman International).
Hayden, Michael, MB, PhD, FRCP(C), FRSC Research focused on how changes in specific genes result in specific diseases,
Director and Senior Scientist, CMMT; Professor, particularly Huntington’s disease and premature coronary artery disease. CRC;
Department of Medical Genetics, UBC Fellow of the Royal Society of Canada; Board of the American Society of Human
(www.cmmt.ubc.ca/hayden/) Genetics; 1998 Distinguished Scientist Award, Canadian Society of Clinical
Investigation; 2000 B.C. Biotechnology Alliance Award for Vision and Leadership;
2001 Award of Excellence, Genetics Society of Canada; 2001 Ottawa Life Sciences
Award of Merit. Previously the director and founder of the Canadian Genetics
Disease Network. Chief Scientific Officer of Xenon Pharmaceuticals Inc.
Hertzman, Clyde, MD, FRCPC Research focused on childhood development and health, including neurobiological
Director, Human Early Learning Partnership (HELP), development; CRC; Fellow of the Experience-based Brain and Biological
UBC; Associate Director, Centre for Health Services and Development Program and the Successful Societies Programs of CIAR; Advisory
Policy Research, UBC. Professor, Department of Health Board Member, Institute of Population and Public Health, CIHR; Governing Council
Care & Epidemiology, UBC (www.earlylearning.ubc. Member and Team Leader, Measurement and Monitoring, Centre of Excellence in
ca/ClydeHertzman.htm) Early Child Development; Member, B.C. Provincial Child Care Council; Advisor, B.C.
Minister of State for Child Care; 2005 Dr. Margaret Corbett Early Child Development
Award from the United Way of the Lower Mainland.
Li, David, MD A world leader in the imaging of multiple sclerosis.
Director, MS/MRI Research Group and Professor,
Department of Radiology, UBC
(http://www.radiology.ubc.ca/research.html)
Simpson, Elizabeth, PhD Research focused on using genetically engineered mouse models to understand
Senior Scientist, CMMT; Associate Professor, Dept. of and improve treatment for human brain and behaviour disorders. CRC; developer
Medical Genetics, UBC of the “Fierce” mouse, which has developmental, neurological and behavioural
(www.cmmt.ubc.ca/simpson/) abnormalities and demonstrates a high level of aggression and violence.
Steeves, John, PhD Research focused on the mechanisms essential to facilitate functional repair after
Director, ICORD Research Centre; Professor, Departments central nervous system damage such as occurs with spinal cord and brain injuries.
of Cellular and Physiological Sciences, Rehabilitation Founder of ICORD; the John and Penny Ryan B.C. Leadership Chair in Spinal Cord
Sciences, Surgery (Neurosurgery), and Zoology, UBC Injury Research (a $6 million endowed professorship); Secretary General of the
(www.icord.org/cgi/profile.cgi?id=414) International Society of Developmental Neuroscience; Director of the Rick Hansen
Spinal Cord Injury Network’s (SCI-Net) SCI Translational Research Network; past
Chair of the Clinical Trials Workshop of the International Campaign for Cures
for Spinal Cord Injury Paralysis (ICCP). Past President or Board Director of Neuro
Therapeutics, Inc., AmberMed Corp, Ascent Biotechnologies Inc.
15 The Heart and Stroke Foundation of B.C. & Yukon (Yu Tian Wang, Chair in Stroke Research); the Rick Hansen Foundation
(Armin Curt, Chair in SCI Rehabilitation Research; Wolfram Tetzlaff, Chair in SCI Research; Matt Ramer, BC Neurotrauma
Professorship Endowment); Cordula and Gunter Paetzold (Marcel Dvorak, Chair in Spinal Cord Clinical Research); LEEF (Allan
Young, B.C. Leadership Chair in Depression Research; John Steeves, John and Penny Ryan B.C. Leadership Chair in Spinal Cord
Injury Research; Michael Krausz, Leadership Chair in Addictions Research).
Neuroscience Asset M ap 15
Net w o r k s
Our key researchers are pivotal players in numerous pan-Canadian and international research
networks (Table 3).
Table 3
National and International Networks Involving B.C.’s Neuroscientists
Network Description
Alzheimer’s Disease Neuroimaging Initiative A major research study, sponsored by the US NIH, to
(www.nia.nih.gov/Alzheimers/ResearchInformation/ determine whether brain imaging can help predict
ClinicalTrials/ADNI.htm) onset and monitor progression of Alzheimer’s disease.
Canadian Consortium of Clinical Cognitive Research Nationwide network of 35 clinics that evaluates
Centres (C5R) and treats individuals with dementia and cognitive
(www.c5r.ca) disorders.
Canadian Movement Disorder Group Canadian clinicians and scientists with an interest
(www.cmdg.org) and expertise in the study and care of patients with
movement disorders.
Canadian Network of Multiple Sclerosis Clinics Academic and community based clinics established for
(http://cnmsc.org/Canadian-Network-Of-Multiple- the advancement of patient services, education and
Sclerosis-Clinics.aspx) research in MS.
Canadian Stroke Consortium Academic alliance committed to the pursuit of anti-
(www.strokeconsortium.ca) stroke therapies, chaired by UBC’s Dr Phil Teal (Director
of the BC Centre for Stroke and Cerebrovascular
Diseases) and involving over 135 Canadian neurologists
and research consultants.
Canadian Stroke Network Canadian Federal government Network of Centres of
(www.canadianstrokenetwork.ca) Excellence (NCE) based in Ottawa.
Consortium of Multiple Sclerosis Centers Professional organization for MS healthcare providers
(www.mscare.org) and researchers in North America.
PrioNet Canada Canadian NCE dedicated to prion research based in
(www.prionetcanada.ca) Vancouver and directed by UBC’s Dr. Neil Cashman.
Rick Hansen Spinal Cord Injury Network Brings together people with SCI, researchers and service
(rickhansen.com/sections/aboutsciandlinks/docs/ providers to accelerate improvements to the quality of
YearEndSummary.pdf ) life of people with SCI.
World Health Organization Early Child Development Raising the profile of early child development globally.
Knowledge Network Focuses on a broad conceptual approach to early child
(www.who.int/social_determinants/knowledge_ development, targeting three primary developmental
networks/childdev/en/) domains - physical, social/ emotional, and language/
cognitive.
Our researchers are always trying to strengthen their networks and would be happy to discuss
participation in additional consortia.
Supp or t Fac ilit ies
The province is also home to a number of academic research platforms that offer important genomics,
proteomics, microarray and other services to our neuroscientists (Table 4). These centres are involved
with many of the above research projects, either as part of the research team or as a fee-for-service
contractor.
16 B rit ish Columbi a
Table 4
Academic Support Facilities for Neuroscience Research
Facility Services
BioBanks (see Table 5) Materials (tissues, DNA, etc) from patients with both
inherited and sporadic forms of disease.
Centre for Disease Modelling (UBC) Biosafety Containment Level 3 large animal facility;
(under construction) transgenic animal facility; prion research facility for
human and animal diseases.
Centre for Drug Research and Development Early stage drug development.
(www.cdrd.ca)
Centre for Translational and Applied Genomics Genomics and molecular pathology.
(Provincial Health Services Authority/BCCA)
Genome BC Microarray Platform and Gene Array Facility Microarrays.
(Prostate Centre, Vancouver General Hospital [VGH])
(www.prostatecentre.com/facilities/ )
Lentivirus Facility, UBC Hospital Provides specific, recombinant Lentivirus vectors, and
(www.brain.ubc.ca/coreFacilities.php) packaged and purified Lentivirus.
Michael Smith Genome Sciences Centre, Sequencing, mapping, and bioinformatics facilities.
BC Cancer Agency (BCCA)
(www.bcgsc.ca)
Peptide Array Facility (UBC Hospital) Peptide synthesis and innovative protein array
(www.brain.ubc.ca/coreFacilities.php) technology
Rick Hansen Spinal Cord Injury Registry National database based in Vancouver that tracks
(www.rickhansenregistry.org) specific outcome measures for people with traumatic
forms of SCI and provides invaluable research data
UBiC (the UBC Bioinformatics Centre) Bioinformatics
(www.bioinformatics.ubc.ca)
Transgenic animal facilities Research facilities at UBC Biomedical Research Centre,
CMMT, Terry Fox Laboratory (BCCA)
UVic - Genome BC Proteomics Centre Proteomics
(www.proteincentre.com)
BioB anks
Because of its public health system, province-wide tertiary care clinics and the multidisciplinary
research encouraged by the Brain Research Centre and ICORD, B.C. is uniquely positioned to have
large banks of ethically approved clinical materials (e.g., tissues, DNA, blood, images) and protected
accompanying clinical information from donors (Table 5). The province is also home to the Rick
Hansen Spinal Cord Injury Registry (Table 4). The unique biological materials and data provided by
these biobanks and the registry are available to researchers and companies to support neuroscience
research in B.C., Canada and worldwide (subject to consent).
Neuroscience Asset M ap 17
Table 5
Neuroscience BioBanks in B.C.
Disease/Clinic BioBanks Contact (see Appendix 1 for details)
Alzheimer’s disease (AD), ALS, Parkinson’s disease (PD) McGeer, Pat
AD, dementia Feldman, Howard; MacKenzie, Ian
Amyotrophic lateral sclerosis (ALS) Cashman, Neil
Epilepsy Townsend, Tiffany
Eye Bank of BC; Eye Donation and Cornea Transplant VGH (T: 604-875-4567; 1-800-667-2060) http://www2.
Program vpl.vancouver.bc.ca/DBs/Redbook/orgPgs/3/3123.html
Eye tissue Matsubara, Joanne
Huntington’s disease Hayden, Michael; Raymond, Lynn
Multiple sclerosis Devonshire, Virginia; Oger, Joel; Traboulsee, Tony
Neuromuscular Gibson, Gillian
Neuro-oncology Thiessen, Brian
PD Stoessl, A Jonathan
Stroke Teal, Philip
Contract Rese arc h wit h B .C .’s Neurosc ience Rese arc hers
B.C.’s neuroscientists had at least 365 agreements or contracts with 138 companies worth a
minimum of $54M over the past five years. Industrial partners included small start-ups and major
pharmaceutical and instrumentation companies, with individual investments ranging from just $186
to over $4.3M (median $43,000). One major pharmaceutical company invested almost $11M in
several different projects. Seventeen of the world’s top 20 pharmaceutical companies have worked
with B.C.’s neuroscientists since 2001/2002, including nine of the top 10 in terms of 2005 sales
(Table 6).
Table 6
Top Ten Pharmaceutical Companies Working With B.C.’s Neuroscientists Since 2001/2
• AstraZeneca • Bristol Myers-Squibb • GlaxoSmithKline
• Hoffmann-La Roche • Johnson & Johnson • Merck & Co.
• Novartis • Pfizer • Sanofi-Aventis
18 B rit ish Columbi a
Tec hnolog y Tr a ns f er Ac t iv it y f r o m B .C .’s Neu r o s c i ent i st s
B.C.’s neuroscientists have received at least 79 U.S. patents between them. An additional 50
international applications have been made through the Patent Cooperation Treaty (PCT) (Figure
13). Thirty one of these inventions have been licensed to at least 22 different companies throughout
North America and Europe (Figure 14). The others continue to provide opportunities to potential
partners.
Figure 13 Number 0 50 100 150 200 250
Intellectual PCT Applications 50
Property Resulting Issued US Patents 79
from Neuroscience
Invention Disclosures 207
Research in B.C.
Figure 14
Licensees of B.C.’s
Neuroscience
Inventions
B.C. 40%
U.S. 41%
European 14%
Other Canadian 5%
Inventions from the BCCA, SFU and UBC have also formed the basis for numerous B.C. companies,
eight of which are still independently operating (Appendix 4). One of these companies, Neuromed
Pharmaceuticals Inc., signed a research collaboration and license agreement with Merck & Co. in
March 2006 worth $450M in milestone payments–the largest such deal reported for a Canadian
biotech company. At least four other neuroscience-related companies spun-off from our universities
have been acquired (Table 7).
Table 7
Purchasers of Spin-Off Companies Based on B.C.’s Neuroscience Research
Local Company Spin-Off Purchaser Year Price
ImmGenics UBC Abgenix Inc., CA (purchased by Amgen in 2005 for $2.2B) 2000 $77M
Pharmaceuticals
Neurostream SFU Victhom Human Bionics Inc. Quebec 2004 $7.17M
Technologies
NeuroVir UBC MediGene AG, Germany 2000 N/A
Therapeutics
Synapse UBC Biomarin Pharmaceutical Inc., CA 1997 $10.2M
Technologies -16.2M
Neuroscience Asset M ap 19
B .C . Companies Involved in Neurosc ienc e
At least six other companies in B.C. are focused on neuroscience (Appendix 4). The 14 B.C.
neuroscience companies range in size from two to 360 employees with products spanning the
development and commercialization spectrum. Two companies have marketed or approved products
or services, while five others are still involved in the discovery research or preclinical phase of their
first neuroscience product (Figure 15).
Figure 15
Stage of Development of B.C.’s 14 Non-clinical 6 (40%)
Neuroscience Companies
Phase I/II 2 (13%)
Phase II 4 (27%)
Phase III 1 (7%) Marketed 2 (13%)
Figure 16 Number 0 1 2 3 4 5
Conditions 4
Alzheimer's/other cognitive impairment
Targeted by B.C.’s
14 Neuroscience
Companies Pain 3
Cancer 2
Eye disorders 2
Schizophrenia 1
Multiple sclerosis 1
Neuroscience research reagents 1
Twelve (86 per cent) companies are developing therapeutics, while diagnostics and reagents are each
being developed by a single company. The most common disease focus is Alzheimer’s or other aspects
of impaired cognition (29 per cent) and pain (21 per cent) (Figure 16).
Most of B.C.’s companies have limited in-house expertise in formulation development,
manufacturing and commercialization. They also have limited capacity to conduct toxicology, animal
pharmacokinetics or clinical trials in-house. Thus, many aspects of the product development and
commercialization process tend to be contracted out.
20 B rit ish Columbi a
Left: PET
scanning is used
to study disease
progression
and response
to treatment
in Parkinson’s
patients.
Opport uniti es for Coll abor at ion
The aforementioned has highlighted B.C.’s assets and collaborative opportunities in neuroscience
research and commercial activities. Both B.C.’s researchers and companies provide opportunities for
interested parties, whether they are other research groups, not-for-profit organizations, governments
or companies. There are many opportunities for collaborative research and opportunities to discuss
participation in additional networks to those mentioned above.
Partners who can effectively translate research findings to the bedside are particularly sought
after. There are opportunities for investigators who have medicinal chemistry, drug synthesis,
pharmacokinetics, formulation development, GMP manufacture and toxicology facilities.
Furthermore, given the large number of B.C. patients who consent to enter clinical trials and the
wealth of patient data associated with our registries and biobanks, there is opportunity to work with
more companies on both their early (Phases I and II) and later stage clinical compounds. There is
great interest in fostering partnerships that allow the development of additional subject/patient
registries and health information databases.
In addition, although B.C. is home to three Biosafety Containment Level [BSCL] facilities
(including a soon-to-be completed large animal centre with capacity for research on human and
animal prion diseases), there is interest in working with other such facilities, or with researchers
wanting to do collaborations making use of BSCL facilities. We do not have BSCL 4 facilities in B.C.
and there is great interest in working with groups with such access.
Neuroscience Asset M ap 21
Con tacts
Organiz ation Phone URL
B.C. Ministry of Economic Development 250-952-0612 www.investbc.com
LifeSciences BC 604-669-9909 www.bcbiotech.ca
BC Cancer Agency Technology Development Office 604-675-8198 www.bccancer.bc.ca
Brain Research Centre 604-822-7246 www.brain.ubc.ca
Centre for Drug Research and Development 604-221-7750 www.cdrd.ca
Centre for Molecular Medicine and Therapeutics 604-875-3800 www.cmmt.ubc.ca
ICORD 604-822-2673 www.icord.org
Simon Fraser University Office of the Vice-President Research 604-291-4152 www.sfu.ca/vpresearch/
University of British Columbia University-Industry Liaison Office 604-822-8580 www.uilo.ubc.ca
University of Northern British Columbia Office of Research 250-960-5820 www.unbc.ca
University of Victoria Office of the Vice-President Research 250-721-7973 www.research.uvic.ca
Ack now ledgemen ts
We would like to thank everyone who participated in the creation of this document including
Todd Tessier, Director of International Capital Markets, B.C. Ministry of Economic Development;
Matthew Brown, Senior Manager, Investment Capital Branch, B.C. Ministry of Economic
Development; Sue Kingsley, President, International BioPharma Solutions Ltd.; Helen Kingsley,
International BioPharma Solutions Ltd.; Angus Livingstone, Managing Director, University of
British Columbia (UBC) University-Industry Liaison Office (UBC-UILO); Caroline Bruce,
Associate Director, UBC-UILO; Brynmor Rees, Technology Transfer Officer, UBC-UILO;
Howard Feldman, Professor and Head, UBC Division of Neurology; Max Cyander, Director,
Brain Research Centre, UBC/Vancouver Coastal Health (VCH); John Steeves, Director of
ICORD, UBC and VCH; Chris McBride, Managing Director, ICORD; Anne Martin-Matthews,
Scientific Director, Institute of Aging, Canadian Institutes of Health Research, and Professor,
School of Social Work and Family Studies, UBC; Susan Crawford, Assistant Director, Institute
of Aging, UBC; Trevor Young and colleagues, Department of Psychiatry, UBC; Sam Abraham,
Director Technology Development, B.C. Cancer Agency (BCCA); Patrick Rebstein, Technology
Development Office, BCCA; Marion Kealy, Research Operations Co-Ordinator, BCCA; Ellen
Loosley, Director, Office of Research Services, Simon Fraser University (SFU); Ziba Afshar,
Technology Manager Life Sciences, SFU UILO; Melanie Monk, Executive Secretary to the
Vice-President, Research, SFU; Mario Pinto, Vice-President (VP), Research, SFU; Eric Roth,
Grants Facilitator, Population Health & Health Services, University of Victoria (UVic); Martin
Taylor, VP Research, UVic; Melanie Toner, Health Research Project Officer, Office of Research,
University of Northern British Columbia (UNBC); Max Blouw, VP Research, UNBC; Natalie
Dakers, CEO, Centre for Drug Research and Development; Karimah Es Sabar, Executive Director,
B.C. Biotech; Barry Gee, Director Operations and Communications, B.C. Biotech; Alan Winter,
President and CEO, Genome B.C.; Gabe Kalmar, Executive Director of Operations, Genome
B.C.; David Dolphin, Chief Executive Officer, B.C. Innovation Council; other scientists at our
universities.
22 B rit ish Columbi a
A ppendix 1
B .C . Depar tment s and Ot her Centres involved in Neurosc ienc e
Re se arc h
SFU
Department Faculty
Biological Sciences Science
Chemistry Science
Computing Science Applied Sciences
Education Education
Engineering Science Applied Sciences
Gerontology Arts and Social Sciences
History Arts and Social Sciences
Kinesiology Applied Sciences
Linguistics Arts and Social Sciences
Molecular Biology & Biochemistry Science
Physics Science
Psychology Arts and Social Sciences
School of Interact Arts & Technology Applied Sciences
UBC
Department Faculty
Anesthesiology, Pharmacology & Therapeutics Medicine
Asian Studies Arts
Audiology & Speech Sciences Medicine
Biochemistry & Molecular Biology Medicine
Biomedical Research Centre Medicine
Brain Research Centre Medicine
Cellular & Physiological Sciences Medicine
Chemistry Science
CMMT Medicine
Computer Science Science
Curriculum Studies Education
Educational & Counselling Psychology & Special Education Education
Electrical and Computer Engineering Applied Science
Family Practice Medicine
Forest Resources Management Forestry
Health Care/Epidemiology Medicine
Health Promotion Research Graduate Studies
Human Early Learning Part. Graduate Studies
Human Kinetics Education
ICORD College for Interdisciplinary Studies
Neuroscience Asset M ap 23
Linguistics Arts
Mechanical Engineering Applied Science
Medical Genetics Medicine
Medicine Medicine
Michael Smith Laboratories VP Academic (Academic Units)
Neurology Medicine
Nursing Applied Science
Ophthalmology & Visual Science Medicine
Orthopaedics Medicine
Paediatrics Medicine
Pathology & Laboratory Medicine Medicine
Physics and Astronomy Science
Psychiatry Medicine
Psychology Arts
Radiology Medicine
Rehabilitation Sciences Medicine
Resources, Environment & Sustainability Graduate Studies
Social Work & Family Studies Arts
Surgery Medicine
Zoology Science
Pharmaceutical Sciences
Sauder School of Business
UBCO Graduate Studies
UNBC
Department Faculty
Northern Medical Program Arts, Social and Health Sciences
Psychology Arts, Social and Health Sciences
U Vic
Department Faculty
Biology Science
Educational Psychology and Leadership Studies Human and Social Development
Mathematics Science
Physical Education Education
Physics + Astronomy Science
Psychology Social Sciences
Othe r
BCCA
BC Institute of Technology (BCIT)
Children’s & Women’s Health Centre
Providence Health Care (PHC)
Vancouver Coastal Health Research Institute
24 B rit ish Columbi a
A ppendix 2
Neu r o s c i enc e Re s e a r c her s i n B .C . I nc luded i n t he A na l y s i s
Other important neuroscientists, who were not included in the analysis, are listed at the end of this
Table.
Researcher Dept Faculty Univ URL
Abugharbieh, Rafeef Electrical and Applied Science UBC www.ece.ubc.ca/~rafeef/
Computer Eng
Allan, Douglas Cellular and Medicine UBC www.cellphys.ubc.ca/faculty_pages/
Physiological Sc allan.html
Anton, Hubert Medicine Medicine UBC www.directory.ubc.ca/index.cfm?page
=personDetail&row=20301436
Aquino, Karl Sauder School of UBC www.sauder.ubc.ca/faculty/directory/
Business faculty/aquino.cfm
Atkins, Stella Computing Science SFU http://www.cs.sfu.ca/~stella/
Auld, Vanessa Zoology Science UBC www.zoology.ubc.ca/zoology/z/auld/
index.html
Baimbridge, Kenneth Cellular and Medicine UBC www.cellphys.ubc.ca/faculty_pages/
Physiological Sc baimbridge.html
Barr, Alasdair Psychiatry Medicine UBC www.msfhr.org/sub-funding-
recipients-profile.asp?award_
recipient_id=607
Barr, Ronald * Paediatrics Medicine UBC www.bcricwh.bc.ca/our_research/
researchers/search_researchers/
researcher_detail.asp?ID=10
Bartholomew, Kim Psychology SFU www.psyc.sfu.ca/people/faculty.
php?topic=finf&id=66
Barton, Jason * Medicine Medicine UBC www.neuroophthalmology.ca/
UBCNeuroOp/JBarton/FrJBhome.html
Beattie, Lynn Medicine Medicine UBC www.crpd.ubc.ca/people/detailed_
35417/default
Beg, Faisal Engineering Science SFU http://www.ensc.sfu.ca/~mfbeg/
Birch, Gary Electrical and Applied Science UBC www.icord.org/cgi/profile.cgi?id=489
Computer Eng
Birmingham, Laird Psychiatry/ Medicine UBC www.bcricwh.bc.ca/our_research/
Medicine researchers/search_researchers/
researcher_detail.asp?ID=11
Bishop, Carole ICORD; Psychology Science; Arts UBC www.orthosurgery.ubc.ca/faculty_
bios/carole_bishop.html
www.icord.org/cgi/profile.cgi?id=547
Blair, Mark Psychology SFU http://www.sfu.ca/psyc/faculty/blair
Bottorff, Joan Nursing Applied Science UBC www.nursing.ubc.ca/faculty/
memberbio.asp?c=68.30812543175
226 www.ubc.ca/
okanagan/nursing/Faculty/jolb.html
Bressler, Bernie Cellular and Medicine UBC www.cellphys.ubc.ca/faculty_pages/
Physiological Sc/ bressler.html
Medicine - Dean’s
Office
Brink, Johann Psychiatry Medicine UBC www.mhanet.ca/search/?q=node/22
Bub, Daniel Psychology Social Sciences UVic http://web.uvic.ca/psyc/bub/
Neuroscience Asset M ap 25
Buchan, Alison Cellular and Medicine UBC www.cellphys.ubc.ca/faculty_pages/
Physiological Sc buchan.html
Cadell, Susan Social Work and Arts; Science UBC www.icord.org/cgi/profile.cgi?id=599
Family Studies;
ICORD
Cairns, Brian * Pharmaceutical UBC www.pharmacy.ubc.ca/faculty_staff/
Sciences faculty/pharm_toxi/pharm_toxi_
brian_cairns.html
Calne, Donald Medicine Medicine UBC www.parkinsons.ubc.ca/Dr.D.B.Calne.
htm
Campbell, Jennifer Psychology Arts UBC www.psych.ubc.ca/faculty/profile/
index.psy?fullname=Campbell,%20Jen
nifer&area=Social/Personality&designa
tion=emeritus
Carlson, Scott Psychology Arts UBC www.psych.ubc.ca/faculty/profile/
index.psy?fullname=Carlson,%20Scott
&area=Clinical&designation=core
Carpendale, Jeremy Psychology SFU http://www.psyc.sfu.ca/people/index.
php?topic=finf&id=67
Carpenter, Mark * Human Kinetics Education UBC www.hkin.educ.ubc.ca/faculty/
carpenterm/CarpenterMark.htm
Cashman, Neil * Medicine Medicine UBC www.chairs.gc.ca/web/chairholders/
viewprofile_e.asp?id=1211&
Celler, Anna Radiology Medicine UBC www.directory.ubc.ca/index.cfm?page
=personDetail&row=119299048
Chapman, Alexander Psychology SFU http://www.psyc.sfu.ca/people/
faculty.php?topic=finf&id=97
Chiu, Lyren Nursing Applied Science UBC www.nursing.ubc.ca/Faculty/
memberbio.asp?c=68.381283989115
Choi, Peter Anesthesiology, Medicine UBC www.anesthesia.med.ubc.ca/cfmx/
Pharmacology and anesthesia/common/oneFaculty.
Therapeutics cfm?USERID=50
Chow, Robert Biology Science UVic http://web/uvic.ca/biology/People/
chow/htm
Christie, Brian Psychology Arts UBC www.psych.ubc.ca/faculty/profile/
index.psy?fullname=Christie,%20Brian
&area=Behavioural%20Neuroscience&
designation=core
Christoff, Kalina Psychology Arts UBC www.psych.ubc.ca/faculty/profile/
index.psy?fullname=Christoff,%20Kali
na&area=Cognitive%20Science&desig
nation=core
Chua, Romeo Human Kinetics Education UBC www.hkin.educ.ubc.ca/faculty/chuar/
chuar.htm
Church, John Cellular and Medicine UBC www.cellphys.ubc.ca/faculty_pages/
Physiological Sc church.html
Clark, Campbell Psychiatry Medicine UBC www.directory.ubc.ca/index.cfm?page
=personDetail&row=139897930
Connolly, Deb Psychology SFU www.psyc.sfu.ca/people/faculty.
php?topic=finf&id=52
Coren, Stanley Psychology Arts UBC www.directory.ubc.ca/index.cfm?page
=personDetail&row=155423953
Cox, David Psychology SFU www.psyc.sfu.ca/people/faculty.
php?topic=finf&id=56
26 B rit ish Columbi a
Craig, Ann Marie * Psychiatry Medicine UBC www.interchange.ubc.ca/neurosci/
craig.htm
Craig, Kenneth Psychology Arts UBC www.directory.ubc.ca/index.cfm?page
=personDetail&row=159728197
Crawford, Charles Psychology SFU http://www.sfu.ca/psyc/faculty/
crawford/
Cripton, Peter Mechanical Applied Sci; Science UBC www.mech.ubc.ca/facstaff/cripton.
Engineering; shtml
ICORD
Crocker, Peter Human Kinetics Education UBC www.hkin.educ.ubc.ca/faculty/
crockerp/crockerp.htm
Cynader, Max * Brain Research Medicine UBC www.brain.ubc.ca/Dr.MaxCynader.php
Centre
Dahl, Darren Sauder School of UBC www.sauder.ubc.ca/faculty/directory/
Business faculty/dahl.cfm
De Freitas, Nando Computer Science Science UBC www.cs.ubc.ca/~nando/
Dedhar, Shoukat Biochemistry and Medicine UBC www.biochem.ubc.ca/fac_research/
Molec Biology faculty/dedhar.html
Delaney, Kerry Biology Science UVic http://www.sfu.ca/~kdelaney/
Devonshire, Virginia Medicine Medicine UBC www.directory.ubc.ca/index.cfm?page
=personDetail&row=899751733
Di Lollo, Vincent Psychology Arts UBC www.interchange.ubc.ca/enzo/
Diamond, Adele * Psychiatry Medicine UBC www.bcricwh.bc.ca/our_research/
researchers/search_researchers/
researcher_detail.asp?ID=32
Donnelly, Martha Family Practice/ Medicine UBC www.directory.ubc.ca/index.cfm?page
Psychiatry =personDetail&row=1000005081
Dorovini-Zis, Katerina Pathology and Medicine UBC www.pathology.ubc.ca/html/
Laboratory Med FacultyProfiles/DoroviniZisKaterina.
html
Doudet, Doris Medicine Medicine UBC www.interchange.ubc.ca/neurosci/
doudet.htm
Douglas, Kevin Psychology SFU www.psyc.sfu.ca/people/faculty.
php?topic=finf&id=86
Dunn, Elizabeth Psychology Arts UBC www.psych.ubc.ca/~edunn/index.htm
Durity, Felix Surgery Medicine UBC www.surgery.ubc.ca/faculty/fdurity.
html
Dutton, Donald Psychology Arts UBC members.shaw.ca/DonDutton/
contents.htm
Dvorak, Marcel Orthopaedics/ Medicine/Science UBC www.orthosurgery.ubc.ca/faculty_
ICORD bios/dvorak.html
Edwards, Roderick Mathematics Science UVic http://www.math.uvic.ca/faculty/
edwards/
Eich, Eric Psychology Arts UBC www.psych.ubc.ca/faculty/profile/
index.psy?fullname=Eich,%20Eric&ar
ea=Cognitive%20Science&designati
on=core
Eisen, Andrew Medicine Medicine UBC www.directory.ubc.ca/index.cfm?page
=personDetail&row=214914754
El-Husseini, Alaa Psychiatry Medicine UBC www.interchange.ubc.ca/neurosci/
husseini.htm
Elliott, Stacy Psychiatry; Medicine; Science UBC www.icord.org/cgi/profile.cgi?id=420
ICORD
Neuroscience Asset M ap 27
Eng, Janice Rehabilitation Medicine/Science UBC www.rehab.ubc.ca/directory/eng.htm
Sciences/ICORD
Enns, James Psychology Arts UBC www.interchange.ubc.ca/vsearch/
people/jim_index.html
Farrell, Kevin Paediatrics Medicine UBC www.bcricwh.bc.ca/our_research/
researchers/search_researchers/
researcher_detail.asp?ID=38
Feldman, Howard Medicine Medicine UBC www.dementiacongress.com/
archive/demcon2/bios/Feldman_
facpesenters_faculty.cfm
Fisher, Brian Computer Science Science UBC www.cs.ubc.ca/~fisher/brfisher.work.
School of Interact SFU html; http://www.sfu.ca/~bfisher/vita.
Arts & Technology pdf
Fisher, Charles Orthopaedics; Medicine; Science UBC www.orthosurgery.ubc.ca/faculty_
ICORD bios/fisher.html
Floresco, Stan Psychology Arts UBC www.psych.ubc.ca/faculty/profile/
index.psy?fullname=Floresco,%20Stan
&area=Behavioural%20Neuroscience&
designation=core
Frankish, James Health Promotion Graduate Studies UBC www.jimfrankish.com/
Research
Franks, Ian Human Kinetics Education UBC www.hkin.educ.ubc.ca/faculty/franksi/
mcllab/IanFranks.htm
Friedman, Jan Medical Genetics Medicine UBC www.genomebc.ca/research_tech/
researcher_profiles/friedman.htm
Frisken, Barbara Physics SFU www.sfu.ca/physics/people/faculty/
frisken/profile.html
Galea, Liisa Psychology Arts UBC www.psych.ubc.ca/faculty/profile/
index.psy?fullname=Galea,%20Liisa&ar
ea=Behavioural%20Neuroscience&des
ignation=core&keyword=
Garland, Jane Psychiatry Medicine UBC www.bcricwh.bc.ca/our_research/
researchers/search_researchers/
researcher_detail.asp?ID=44
Giaschi, Deborah Ophthalmology and Medicine UBC http://www.interchange.ubc.ca/
Visual Science giaschi/debbiecv.html
Goldner, Elliot Health Sciences SFU http://www.fhs.sfu.ca/bio.
php?id=1235
Goodman, David Kinesiology SFU http://fas.sfu.ca/kin/profiles/goodman.
shtml
Gouzouasis, Peter Curriculum Studies Education UBC www.cust.educ.ubc.ca/faculty/
gouzouasis.html
Graf, Peter Psychology Arts UBC www.psych.ubc.ca/~pgraf/peter.htm
Grigliatti, Thomas Zoology/ICORD Science UBC www.zoology.ubc.ca/zoology/z/
grigliatti/
Grunau, Ruth Paediatrics Medicine UBC www.psych.ubc.ca/faculty/profile/
index.psy?fullname=Grunau,%20Ruth
&area=&designation=associate
Gutman, Gloria Gerontology SFU http://www.sfu.ca/gerontology/
01faculty_staff/gutman.html
Haas, Kurt Cellular and Medicine UBC www.cellphys.ubc.ca/faculty_pages/
Physiological Sc haas.html
Hadley, Bob Computing Science SFU http://www.cs.sfu.ca/~hadley/
28 B rit ish Columbi a
Hall, Judith Paediatrics Medicine UBC www.science.ca/scientists/
scientistprofile.php?pID=368
Hamarneh, Ghassan Computing Science SFU http://www.csc.sfu.ca/bio.php?id=243
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30 B rit ish Columbi a
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Educ
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32 B rit ish Columbi a
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Oxland, Tom * Orthopaedics Medicine; UBC www.orthosurgery.ubc.ca/faculty_
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Engineering
ICORD
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Phillips, Anthony Psychology Arts UBC www.psych.ubc.ca/faculty/profile/
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bios/wpiper.html; www.directory.ubc.
ca/index.cfm?page=personDetail&row
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Epidemiology html
Prkachin, Ken Psychology UNBC http://web.unbc.ca/~kmprk/
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Roskams, Jane Zoology; Science UBC www.interchange.ubc.ca/neurosci/
Psychiatry Medicine roskams.htm
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Educ
34 B rit ish Columbi a
Schooler, Jonathan * Psychology Arts UBC www.psych.ubc.ca/faculty/profile/
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Strauss, Ester Psychology Social Sciences UVic http://web.uvic.ca/psyc/strauss/
Strayer, Janet Psychology SFU N/A
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Thornton, Allen Psychology SFU www.psyc.sfu.ca/people/faculty.
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36 B rit ish Columbi a
Vincent, Steven Psychiatry Medicine UBC www.grad.ubc.ca/faculty/
directory/?=69
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html
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Computer Eng
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Research Centre wang.htm
Wang, Yue Linguistics SFU http://www.sfu.ca/~yuew/home.htm
Warburton, Darren Human Kinetics/ Education/Science UBC www.hkin.educ.ubc.ca/faculty/
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ca/faculty/memberbio.
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Wasserman, Wyeth Medical Genetics/ Medicine UBC www.cmmt.ubc.ca/wasserman/
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Watson, Neil Psychology SFU www.psyc.sfu.ca/people/faculty.
php?topic=finf&id=42
Weeks, Claire Medicine; Medicine; Science UBC www.directory.ubc.ca/index.cfm?page
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Weeks, Dan Psychology SFU www.psyc.sfu.ca/people/faculty.
php?topic=finf&id=43
Weinberg, H Kinesiology SFU http://fas.sfu.ca/fas/GCMS2/bio.
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Weinberg
Weinberg, Joanne Cellular and Medicine UBC www.interchange.ubc.ca/neurosci/
Physiological Sc weinberg.htm
Wellington, Cheryl Pathology and Medicine UBC www.bcricwh.bc.ca/our_research/
Laboratory Med researchers/search_researchers/
researcher_detail.asp?ID=146
Werker, Janet* Psychology Arts UBC www.psych.ubc.ca/faculty/profile/
index.psy?fullname=Werker,%20Janet
&area=Developmental,%20Cognitive
%20Science&designation=core
Westerberg, Brian Surgery Medicine UBC www.surgery.ubc.ca/faculty/
bwesterberg.htm
Whittlesea, Bruce Psychology SFU http://www.psyc.sfu.ca/people/
faculty.php?topic=finf&id=61
Wood, Evan Medicine Medicine UBC www.healthcare.ubc.ca/bio/wood.
html
Woodham, Robert Computer Science Science UBC www.cs.ubc.ca/people/profile.
jsp?id=woodham
Woolfenden, Andrew Medicine Medicine UBC www.directory.ubc.ca/index.cfm?page
=personDetail&row=1000001215
Wright, Richard Psychology SFU http://www.sfu.ca/~rwright/
Neuroscience Asset M ap 37
Wright, Steve* Psychology SFU http://www.sfu.ca/psyc/faculty/
wrights/
Xu, Fei* Psychology Arts UBC www.psych.ubc.ca/~fei/
Yatham, Lakshmi Psychiatry Medicine UBC www.mhanet.ca/search/?q=node/134
Young, Arlene Psychology SFU www.psyc.sfu.ca/people/faculty.
php?topic=finf&id=73
Zehr, Paul Physical Education Education UVic http://www.educ.uvic.ca/Faculty/
pzehr/
Zhang, Richard Computing Science SFU http://www.csc.sfu.ca/bio.php?id=317
Zis, Athanasios Psychiatry Medicine UBC www.directory.ubc.ca/index.cfm?page
=personDetail&row=898982104
Other Important Neuroscientists in BC (Abbreviations below) Contact
D’Angiulli, Amedeo * Education TRU T: 250-828-8734
adangiulli@tru.ca
Chaudhury, Habib Gerontology SFU www.crpd.ubc.ca/people/detailed_
35418/default
Curt, Armin Rehabilitation Medicine UBC T: 604 822-2673
Sciences/ ICORD
Drance, Elisabeth Psychiatry Medicine UBC/ www.crpd.ubc.ca/people/detailed_
PHC/ VCH 35421/default
Forwell, Sue Rehabilitation Medicine UBC www.rehab.ubc.ca/directory/forwell.
Sciences htm
Gibson, Gillian Neuromuscular VGH T: 604 875-4247
Diseases Unit gillian.gibson@vch.ca
Hulko, Wendy Social Work and TRU www.crpd.ubc.ca/people/detailed_
Human Service 35431/default
Krausz, Michael Psychiatry Medicine UBC/ Tel: 604 806-9113
PHC
O’Connor, Deborah Social Work and Arts UBC www.crpd.ubc.ca/people/detailed_
Family Studies 35416/default
Phinney, Alison Nursing Applied Science UBC www.crpd.ubc.ca/people/detailed_
35425/default
Purves, Barbara Audiology and Medicine UBC www.crpd.ubc.ca/people/detailed_
Speech Sciences 35426/default
Small, Jeff Audiology and Medicine UBC www.crpd.ubc.ca/people/detailed_
Speech Sciences 35427/default
Smith, Andre Sociology UVic www.crpd.ubc.ca/people/detailed_
35428/default
Townsend, Tiffany Neurology Medicine VGH T: 604 875-4111 x 62985
tiffany.townsend@vch.ca
Traboulsee, Tony Neurology Medicine UBC T: 604 822-7915 trabouls@interchange.
ubc.ca
Watzke, James Health Technology Applied Research BCIT www.bcit.ca/appliedresearch/health/
team/jwatzke.shtml
Young, Allan Psychiatry Medicine UBC T: 604 827-3685
allan.young@ubc.ca
Young, Trevor Psychiatry Medicine UBC T: 604 822-7310
head.psychiatry@ubc.ca
Symbol s and Abbreviations
* Canada Research Chair
B C I T = BC Institute of Technology
PHC = Providence Health Care
T RU = Thompson Rivers University
VC H = Vancouver Coastal Health Authority
VG H = Vancouver General Hospital
38 B rit ish Columbi a
Left Top: Neuroproteomics is used to
study signalling in the brain.
Left Middle: 1.5 Kg of brain uses
20% of our blood supply. This image
shows a blood vessel surrounded by
astrocytes.
Left Bottom: Researchers study blood
flow regulation in the living brain.
Neuroscience Asset M ap 39
A ppendix 3
B .C .’s Canad a Rese arc h Chairs Involved in Neurosc ience Rese arc h
Researcher University Canada Research Chair
Barr, Ronald UBC Community Child Health
Barton, Jason UBC Neuropsychology of Vision and Eye Movements
Cairns, Brian UBC Neuropharmacology
Carpenter, Mark UBC Physical Activity and Health
Cashman, Neil UBC Neurodegeneration and Protein Misfolding Diseases
Craig, Ann Marie UBC Neurobiology
Cynader, Max UBC Brain Development
D’Angiulli, Amedeo TRU Early Intervention and Child Development
Diamond, Adele UBC Developmental Cognitive Neuroscience
Hayden, Michael UBC Human Genetics and Molecular Medicine
Hertzman, Clyde UBC Population Health and Human Development
Mackworth, Alan UBC Computational Intelligence
MacVicar, Brian UBC Neuroscience
McDonald, John Joseph SFU Cognitive Neuroscience
Molday, Robert UBC Visual Science
Naus, Christian UBC Gap Junctions and Disease
Oxland, Tom UBC Spinal Cord Biomechanics
Pai, Dinesh UBC Sensorimotor Computation
Rossi, Fabio UBC Regenerative Medicine
Schechter, Martin UBC HIV/AIDS and Urban Population Health
Schooler, Jonathan UBC Social Cognitive Science
Schrader, John UBC Immunology
Seamans, Jeremy UBC Neurobiology of Mental Health and Addiction
Simpson, Elizabeth UBC Genetics and Behaviour
Slingerland, Edward UBC Chinese Thought and Embodied Cognition
Snutch, Terrance UBC Biotechnology and Genomics - Neurobiology
Song, Weihong UBC Alzheimer’s Disease
Stoessl, A Jonathan UBC CNS Disorders
Vatikiotis-Bateson, Eric UBC Speech and Cognitive Science
Vocadlo, David SFU Chemical Biology
Werker, Janet UBC Psychology
Wright, Steve SFU Social Psychology
Xu, Fei UBC Developmental Cognitive Science
40 B rit ish Columbi a
A ppendix 4
B .C . Co mpanies Act ive in Neurosc ienc e
Company and Technology Lead Neuroscience Product Disease
Date of Startup
Allon Therapeutics (2001) Neuroprotective drugs derived from activity-dependent • AL-108 • Alzheimer’s, schizophrenia
neuroprotective protein and activity-dependent neurotrophic • AL-208 • Mild cognitive impairment,
factor. stroke
Amorfix Life Sciences Ltd. Epitope protection technology: diagnostic assays to detect • vCJD diagnostic • Variant Creutzfeldt-Jacob
(2004) aggregated misfolded proteins in peripheral blood. • EP-AD™ disease
• Alzheimer’s
Chemokine Therapeutics Corp. Identify chemokines and their associated receptors to develop • CTCE–9908: CXCR4 antagonist; • Cancer including brain
(1998) novel synthetic peptide analogs. • CTCE-0501 • Stroke
Chromos Molecular Systems, Humanized monoclonal antibody. CHR-1103 Acute relapses associated with
Inc. (1995) relapsing forms of multiple sclerosis
Clera Inc. (2001) Small-molecule therapies targeted to D2 receptors. CLR151 Schizophrenia and psychosis
iCo Therapeutics Inc. (2005) Antisense inhibitor of c-Raf kinase (important in vascular iCo-007 (ISIS 13650) (antisense) Eye diseases caused by the formation
endothelial growth factor [VEGF] signal transduction pathway). of new blood vessels
Inflazyme Pharmaceuticals Phosphodiesterase 4 (PDE4) inhibitors. IPL455,903 (HT-0712) Age associated memory impairment
Ltd. (1992)
Migenix Inc. (1993) Neuroprotective sodium salt of 17α-estradiol 3-sulphate • MX-4509 • Alzheimer’s
(MX-4509). • MX-4565 • Ophthalmic
Neuromed Pharmaceuticals Selective N-type calcium channel blocker. MK-6721 (NMED-160) Pain
Inc. (1995)
PanaGin Pharmaceuticals, Inc. Saponin-based anti-cancer proprietary compounds that induce • PBD-2131 Brain metastases for both
(2001) apoptosis in cancer cells. • PAM-200
QLT Inc. (1981) Light activated drug used in photodynamic therapy. Visudyne® (verteporfin) Wet age-related macular degeneration
StemCell Technologies Inc. Tissue culture media and cell separation products for neural cell NeuroCult® tissue culture media products; Not relevant
(1993) characterization and separation. immunomagnetic cell separation agents; antibodies
for neural cells
Wex Pharmaceuticals (1992) Sodium channel blocking compound from puffer fish (fugu). 9401-TTX (tetrodotoxin) • Tectin™ - Cancer pain
• Tetrodin - Opiod™ withdrawal
Xenon Pharmaceuticals Inc. Drug targets for common complex diseases identified in key XEN401 (non opoid or cox mechanism) Pain
(2000) genes for rare genetic disorders.
Neuroscience Asset M ap 41
Stage of Capitalization Employees Current Corporate Local Spin-Off URL
Development 06-12-20 (B.C. Based) Collaborations
(or Investment
if Private) C$
• Phase I 50.0M (TSX: NPC) 7 None No www.allontherapeutics.
• Phase II com
Development for both 31.0M (TSXV:AMF) 2 None No www.amorfix.com
• Phase II; 34.6M (TSX:CTI; OTCBB:CHKT) 22 None UBC www.chemokine.net
• Pre-clinical
Pre-clinical 12.4M (TSX:CHR) 27 BD Biosciences, Pfizer, Centocor, No www.chromos. com
Cambridge Antibody Technology,
AppTec, SAFC Bioscience, AviGenics,
Agrisoma Biosciences, T’s Therapeutics
for other technologies
Pre-clinical (Private) N/A 1 None No www.clera.com
IND submitted (Private) N/A 5 ISIS Pharmaceuticals No www.icotherapeutics.com
Phase II 10.2M (TSX:IZP) 30 Helicon Therapeutics UBC www.inflazyme.com
• Phase I 47.9M (TSX:MGI; OTC: MGIFF) 40 Cadence Pharmaceuticals, Cutanea UBC www.migenix.com
• Pre-clinical Life Sciences, Schering-Plough, Pfizer,
Wyeth, Spring Bank Technologies for
other compounds
Phase II Private. $74M invested to date 45 Merck & Co UBC www.neuromed.com
Phase I/II (Private) N/A 14 Pegasus Pharmaceuticals Inc. - UBC www.panagin.com
controlling shareholder of PanaGin
Marketed 736.8M (TSX:QLT; Nasdaq: 360 Novartis; Pfizer, Sanofi-Aventis, Astellas UBC www.qltinc.com
QLTI) Pharma, Sosei, MediGene, Mayne
Pharma for other products
Marketed N/A (Private) 180 None BCCA www.stemcell. com
Phase III 7.0M (TSX:WXI) 5 Laboratorios del Dr. Esteve S.A. No www.wexpharma.com
Phase I
Preclinical 188+ (Private) 70 Takeda; Pfizer, Novartis, Roche for other UBC www.xenon-pharma.com
compounds
42 B rit ish Columbi a
Notes
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