University of Wisconsin
               Hospital and Clinics                               Neon K Ringwood, MS
     Volume 7, Issue 2
        April 2009

                                  Search for Osteoporosis Genes
 Inside this issue:             For the first time ever,     G e n o m e - w i d e         investigated,” he said.
 Gardening           2          an extensive genome-         genotyping,       a   very    “The next step will be
 Bears Yield         3          wide      search     has     demanding and labor-          identifying what those
 Bone Secret
                                been undertaken to           intensive       procedure,    genes are and how
 Bone Mineral        3          find the genes linked        measures            genetic   they might contribute
 Testing                        to osteoporosis and          variations called ‘Snips’,    to our understanding
 Recipe File         4
                                fracture. There are          within each of our            of osteoporosis and
                                30,000 genes in the          30,000 genes,” said           its prevention.” The
                                human genome, but            Garvan’s         Associate    discovery of genes
                                until now few have been      Professor Tuan Nguyen,        linked to osteoporosis
                                unequivocally linked to      who has been involved         will allow researchers
                                osteoporosis and fragility   with the Dubbo project        to     better    develop
                                fractures. The Garvan        for almost 20 years.          prognostic       models,
  B.O.N.E.S.                    Institute for Medical        “The collaborative study      and     help    clinicians
  SUPPORT                       Research collaborated        examined more than            identify individuals with
    GROUP                       with     the    Icelandic    300,000 such markers          high risk of fracture for
                                genetics       company,      and found 12 that were        intervention.
 will meet on                   deCode, in a project         linked to bone mineral
 April 14th at                  that looked at 1500          density and 6 linked to       Garvan Institute for
   Oakwood                      women from Garvan’s          fragility fractures. Some     Medical      Research,
  Auditorium                    Dubbo       Osteoporosis     of these Snips are close      www.gavan.org.
 6209 Mineral                   Epidemiology       Study     to genes that are already     au/news-events
  Point Road                    as well as more than         known to be important         (Search     genotyping
                                12,000 women from            in bone biology, while        osteoporosis.)
   Madison                      Iceland and Denmark.         others are yet to be

1:30-2:30 p.m.
                                         Next B.O.N.E.S. Meetings
Questions? Call                 Tuesday, April 14 - Neil Binkley, MD - Vitamin D: New Research Findings
                                and Their Implications
                                Tuesday, May 12 - Diane Krueger, BS, CBDT - Bone Density Scans -
for information.                What Are They and Why Are They Important?
                                Tuesday, June 2 (Note date change from 2nd Tuesday) - Bjoern Buehring,
                                MD - Falls - Why Do We Fall and What Can We Do to Prevent Falling?
     P.T. Place: Gardening with Osteoporosis                                                                    2

By Barbara Luedke, Senior PT          clude:                                  it close to your body. If you are
                                      1. Consider the option of contain-      carrying items in a bucket, it is
Summers in Wisconsin. For many        er gardening or raised beds.            better to evenly divide the load
of us that means a limited num-       2. Use long handled tools to avoid      between two buckets and carry
ber of months to enjoy a variety      forward bending.                        one in each hand.
of outdoor activities, and garden-    3. Bend from your knees to reach
ing is frequently at the top of the   for an object on the ground.
list. Individuals with osteoporosis   4. Better yet, position yourself
often ask if gardening is an ac-      on the ground, perhaps on your
ceptable activity. The answer is      hands and knees or in a side-sit-
yes, as long as principles of safe    ting position. This is a good op-
movement are followed. The two        portunity to provide weight-bear-
most important precautions are to     ing activities through your arms
avoid forward bending and twist-      and upper body!
ing movements. Each of these          5. If balance or the ability to move
motions produces high loads on        safely from the ground to stand-
the vertebral bodies, especially      ing is an issue, consider using a
when lifting or carrying an object.   stool or a kneeler with hand sup-
A combination of these two mo-        ports. Just remember to keep
tions creates even higher com-        your back straight and bend from
pressive loads on the vertebral       your hips.
                                                                              Enjoy your summer activities. Al-
bodies. Therefore, always main-       6. Always use good body me-
                                                                              ways remember to move safely.
tain good postural alignment and      chanics when shoveling, hoe-
                                                                              Do, but don’t overdo … a diffi-
use good back protective mea-         ing and raking, etc. Do not bend
                                                                              cult concept for persons with a
sures. With gardening, you reap       forward or twist. Instead, stand
                                                                              strong work ethic. Stop before
positive benefits. One is the pride   with your feet apart, and one foot
                                                                              you become tired so you do not
and satisfaction of watching your     slightly ahead of the other. Then
                                                                              place your muscles or bones at
gardens bloom and grow. Anoth-        shift your weight from foot to foot
                                                                              risk for injury and most of all en-
er benefit is the improvement in      in a rocking motion. Remember
                                                                              joy the bounty of your efforts – all
your bone strength and general        to keep your back straight. Do
                                                                              the beautiful flowers and healthy
endurance.                            not perform these activities if you
                                      experience pain or discomfort.
Safe gardening principles in-         7. When carrying an object, hold

   Gardening and Yard Work = Good Exercise
Researchers at the University of      Since so many people enjoy these        rather as a form of leisure activity
Arkansas-Fayetteville found that      activities, they are more likely to     that is pleasurable and rewarded
gardening and yard work qualify       engage in them. Further, many           by blooming plants, a beautiful
as weight-bearing exercise, which     people do not think of gardening        yard or vegetables for the table.
is important for bone strength.       or yard work as exercise, but           http://www.healthatoz.com

               Peace cannot be kept by force. It can only be achieved by understanding.

                                                            Albert Einstein
                         Bears Yield Bone Secret                                                            3

How would you like to be a bear     In the search for bears’ secrets
and have your bone density in-      that could lead to the develop-
crease while you hibernate all      ment of a new drug, Donahue has
winter? Why don’t bears get os-     checked out the animals’ para-
teoporosis? That’s what would       thyroid hormones, which seemed
happen if we hibernated all win-    to be the key to their bone resil-
ter. Seth Donahue and his col-      ience. Research revealed that
leagues of Michigan Tech Uni-       the bears’ hypothalamus, an al-
versity have studied hibernating    mond-size part of the brain that
black and grizzly bears and found   controls a number of metabolic
that their bone mineral content is  and nervous system processes,
maintained during hibernation.      might also be part of the magic
Not only that, a bear’s bones get   within bear bones. Donahue and
stronger and less porous as it      his colleagues have modified a
gets older.                         synthetic bear hormone and have
                                    partnered with a drug company
Donahue discovered these facts to further investigate this poten-
by studying bears from Michigan, tial new treatment.
Virginia, Washington, and Utah,
and by testing the strength of bear “We are optimistic that our new Rozell, Ned, Hibernating bears yield
bones donated by hunters near version of the bear parathyroid bony secret. Alaska Dispatch 2/17/09
his lab in Houghton, Michigan. will eventually lead to a new os-
He wanted find out what makes teoporosis drug for humans,” Do-
bears different from humans.        nahue said.

              Legislation Proposed to Preserve
                   Bone Density Testing
An important part of osteoporosis     follow in their footsteps unless fractures, hospitalizations and
prevention, diagnosis and treat-      the cuts are reversed.            nursing home admissions can be
ment is determining an individu-                                        reduced greatly by the increased
al’s bone mineral density. DXA        Osteoporosis is a preventable, utilization of DXA.
is the best test available to diag-   under-diagnosed and under-
nose and treat osteoporosis.          treated disease. Women count Multiple healthcare provider
                                      for 71% of all osteoporotic frac- groups, and the National Osteo-
Medicare reimbursement for DXA        tures.                            porosis Foundation have been
bone mineral testing in the physi                                       working to reverse this threat
cian’s office has been reduced by     A 2008 study by Kaiser in South- that will limit access to osteopor-
approximately 50% since 2006          ern California demonstrated the sis care. The good news is that
and is scheduled to be cut again      cost-effectiveness of DXA test- Senator Blanche Lincoln and
in 2010. The current rate of $72      ing and treatment. Increasing Senator Olympia Snowe recently
is substantially below the aver-      DXA testing and treatment over introduced legislation in the Sen-
age cost of providng this service,    a 5-year period (2002-2006) re- ate to restore reimbursement
which has been estimated to           sulted in a 37% reduction in hip for bone density testing in the
be $134. Many physicians have         fractures. The cost to the Medi- phyiscian’s office setting.
been forced to discontinue provi-     care budget for payment related
deing this service and more will      to potentially preventable hip International Society for Clinical Densi-
                                                                          tometry www.iscd.org
        University of Wisconsin
        Hospital and Clinics
        2870 University Ave.
        Madison WI 53705

                            RECIPE FILE
                                           Hoppin’ John

1 cup cooked brown rice                                  ½ medium green bell pepper, chopped
2 cups water                                             3 stalks celery, chopped
1 large clove garlic, lightly smashed                    1 jalapeno pepper, chopped (optional)
1 bay leaf                                               ½ tsp. dried thyme leaves
2 cans (15 oz.) black eyed peas, rinsed and drained      ¾ tsp. ground cumin
1 medium onion chopped                                   Salt and freshly ground black pepper, to taste
1 (14 oz,) can diced tomatoes                            4 green onions, sliced
1 medium red bell pepper, chopped

In a large, heavy pan, cook the rice in the water with the garlic and bay leaf for about 30 minutes, or
until the rice is tender.

Add the black-eyed peas, onion, tomatoes (and their juices), red and green bell peppers, celery,
jalapeno pepper, thyme, cumin, salt and pepper. Cover and cook for another 10 to 20 minutes, adding
an additional 1/4-cup water if necessary, until the rice is tender and the vegetables have released
their liquid.

Stir in the sliced green onion. Serve with hot sauce, if desired. Makes 10 servings, 1/2 cup each.

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