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New in NPS RADAR for December Imiquimod cream (Aldara) for


New in NPS RADAR for December Imiquimod cream (Aldara) for ...

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									                       New in NPS RADAR for December

Imiquimod cream (Aldara) for superficial basal cell carcinoma
Basal cell carcinomas (BCCs) are managed routinely in general practice, most
commonly by surgery. When surgery is contraindicated, imiquimod cream is an
alternative for treating superficial BCCs. The latest issue of NPS RADAR gives
guidance on selecting patients and tumours that can be treated safely with

Imiquimod has a lower cure rate than surgery, and unlike surgery there is no
opportunity for histological assessment of tumour clearance. Imiquimod is not
indicated for recurrent, invasive or nodular BCC, and is unsuitable for certain high-
risk facial tumours. Local skin reactions are common with imiquimod and many
patients will need a rest from treatment.

See the complete review on the NPS RADAR website ( from 1
December for more information about using imiquimod. NPS RADAR was mailed to
GPs, pharmacists and most specialists in mid-December 2006.

Also in this issue
• Insulin glargine (Lantus) for type 1 and 2 diabetes mellitus: NPS RADAR
   examines the efficacy of this long-acting analogue of human insulin and
   compares the incidence of hypoglycaemia with that of isophane insulin.
• Amlodipine with atorvastatin (Caduet) for dyslipidaemia with concomitant
   hypertension or angina: This new type of fixed-dose combination preparation
   treats different indications concurrently. NPS RADAR details the quality use of
   medicine issues when using combination preparations.
• Pimecrolimus cream (Elidel) for facial atopic dermatitis (update, web only):
   The authority-required listing of topical pimecrolimus has been extended to
   include adults. NPS RADAR covers the expanded listing and the latest safety
• Rosuvastatin (Crestor) for dyslipidaemia: NPS RADAR considers how the
   efficacy and safety compare with the other statins.
• Erratum: Fentanyl patches (Durogesic) for chronic pain: Equi-analgesic
   doses of methadone have been removed from the table listing equipotent doses
   of opioid analgesics, first published online in August 2006.

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