PMB PREVENTIVE MEDICINE & BIOMETRICS
UNIVERSITY OF COLORADO
DENVER AND HEALTH SCIENCES CENTER
Volume 6 Genetic Variation in Genes
Issue 2 Related to Inflammation and
A new 3-year study of genetic variation in genes
IN THIS ISSUE related to inflammation was recently funded by
the American Diabetes Association to examine
New Research ......... 1 the relationship between variation in those genes
Chair Letter ............. 2 and insulin resistance. Tasha Fingerlin, PhD
Events Schedule ...... 2
Several studies have indicated that there is a relationship between insulin resis-
Faculty Updates ...... 3 tance, a risk factor for type 2 diabetes, and inflammation. Recent studies in
Grants ..................... 4 rodents and humans have demonstrated that a pathway known to influence in-
Faculty Awards ........ 6 flammation, the IKKb/NF-kB pathway, may also influence insulin resistance. When
Section of Biometrics this pathway is disrupted by deleting the gene for the IKKb protein, insulin resis-
and Informatics ... 7 tance is reduced in mice. Similarly, when humans took aspirin, which inhibits the
Section of same protein, insulin resistance was reduced on average. No studies have ex-
Epidemiology and amined the relationship between insulin resistance and the genes for IKKb and
Community Hlth .. 8 NF-kB in humans. This study will test the hypothesis that genetic factors in the
Epi Exchange ......... 10 IKKb/NF-kB pathway are associated with insulin resistance in humans. This
Programs ................ 11 study will also investigate whether these genetic factors interact with each other
to influence insulin resistance and risk of type 2 diabetes. The goal of this work is
New PRAs ............ 13
to identify new genetic factors that contribute to insulin resistance, furthering the
Alumni ................... 15 understanding of the pathogenesis of type 2 diabetes so that future prevention
US Public Health and treatment strategies might be more effective.
Service Conf .... 16
The new study is an ancillary study to the Insulin Resistance and Atherosclerosis
Family Study (IRAS Family Study). The Insulin Resistance Atherosclerosis Study
(IRAS) was a community-based epidemiologic cohort study of 1625 men and
women designed to determine the correlates and predictors of insulin resistance
Submit information for and atherosclerosis. The IRAS Family Study is an extension of IRAS. The re-
the newsletter and deliv- search goals of the IRAS Family Study are to elucidate the genetic determinants
ery address (email or of insulin resistance and visceral adiposity in order to further explore the suscep-
snail mail) updates to tibility to and risk for type 2 diabetes and cardiovascular disease. Families in the
Debra.Becker@uchsc.edu IRAS Family Study were generally recruited from individuals participating in IRAS.
The study includes 710 Hispanic individuals from 22 extended families recruited
from San Antonio, Texas and 717 Hispanic individuals from 22 extended families
recruited from the San Luis Valley, Colorado.
Phone The study is conducted in the Department of Preventive Medicine and Biometrics
303-315-8811 (PMB) through collaboration with the IRAS Family Study (Jill Norris, MPH, PhD,
Fax P.I. of Colorado site) and Wake Forest University. Tasha Fingerlin, PhD, is the
303-315-3183 Principal Investigator. Jill Norris is a co-investigator on the project as is Donald
W. Bowden, PhD, from Wake Forest University. 1
Dear Colleagues and Friends
of Preventive Medicine & Biometrics,
Schedule of Events
Spring is almost here! Unbelievable! It
Please see http://pmb.uchsc.edu/ seems like only yesterday classes were
for locations and updates just getting underway for the fall semester.
Faculty and students are still adjusting to
March 2006 the switch from quarters to semesters, but
6 Grand Rounds I believe the transition so far has gone
12:00 noon – 1:00 pm
2nd Floor Lecture Hall well.
Joseph E. Donnelly, FACSM
“Diet and Exercise for Weight The new year began with some administra-
Reduction and Weight tive changes within the department.
14 Promotion 101 Presentation Jill Norris, who has served for several years as the section head for Epi and
9:00 am - 10:00 am Community Health, stepped down from this administrative role, effective
27 Departmental Seminar February 1st. I personally want to thank her for the outstanding contribu-
12:00 noon – 1:00 pm tions she made to the section and department during her reign. I am
CPH Auditorium pleased to announce that John Hokanson agreed to assume the role as
Stephen Ross, MD section head. Anna Baron started a one year, self-funded sabbatical on
“Interactive Health Technology
to Improve Self-Management”
January 1st. Gary Zerbe graciously agreed to fill in as section head for
Biometrics and Informatics during Anna’s leave. On behalf of the faculty
April 2006 and Executive Committee, I want to thank both John and Gary for their
3 Grand Rounds willingness to take on these leadership positions.
12:00 noon – 1:00 pm
2nd Floor Lecture Hall
Meletios Fotinos, MD, MSPH The department’s annual research seminar, the Epi Exchange, took place
17 Departmental Seminar February 24th. The guest speaker, Dr. George Davey-Smith, MD, DSc,
12:00 noon – 1:00 pm FRCP, presented an interesting and engaging talk “Lifecourse Epidemiol-
CPH Auditorium ogy –A Lifecourse Approach to the Study of Chronic diseases”. It was
Sunmin Lee, PhD
wonderful seeing so many of you at the event this year. Over 120 faculty,
students and professionals in public health joined us for the day filled with
May 2006 presentations, research posters, and networking. Many thanks to Dr. Dana
1 Grand Rounds Dabelea and her committee for organizing such a wonderful event.
12:00 noon – 1:00 pm
2nd Floor Lecture Hall
L. Burhansstipanov, MSPH, DrPH Progress is slow but sure, with the development of the proposed new
“Health Care in Indian Country” School of Public Health. President Hank Brown has joined forces with the
15 Departmental Seminar presidents of CSU and UNC to publicly endorse the development of the
12:00 noon – 1:00 pm school. The three partner institution leaders are talking with state founda-
William Robinson, MD, PhD
tions to obtain start-up monies so that individuals can be funded to continue
“Breast Cancer Etiology” with the many areas of administrative and curriculum development needed
in order to open the school. The Steering Committee for the Colorado
June 2006 School of Public Health Initiative will organize a faculty retreat in the near
5 Grand Rounds future so we can more completely engage faculty at UCDHSC, CSU and
12:00 noon – 1:00 pm
2nd Floor Lecture Hall UNC on this project.
Todd Porter, MD
Lisa VanBramer, MD Thank you for taking a few minutes to read through this newsletter. This
and Tyler Watlington, MD edition is the largest yet – with so much news to share concerning research
“PMB Resident Thesis
projects, new faculty and staff, education program updates and more. I
wish you the best as we leave the gray of winter behind us and enter into
July 2006 the beautiful colors of spring and summer.
August 2006 Richard F. Hamman, MD, DrPH
Professor and Chair
2 Preventive Medicine and Biometrics
Congratulations to the following Faculty
Jessica Bondy, MHA
promoted to Assistant Professor
effective March 1, 2006
Richard Jones, PhD
promoted to Professor Emeritus
effective October 1, 2005
Anna Barón, PhD started a year-long sabbatical on January 1, 2006. During the year she
will be working with her colleague Guillermo Marshall in Chile, extending their joint work on
discriminant analysis for longitudinal data. She will also spend time learning cancer biology
and translational research methods with CU Cancer Center colleagues Gail Eckhardt, leader
of the developmental therapeutics program, and Mark Geraci, director of the gene expres-
While Anna is on sabbatical, Gary O. Zerbe, PhD is Acting Sec-
tion Head for Biometrics and Informatics. With Gary Grunwald’s
continued strong Directorship of the Biostatistics Graduate Pro-
gram, Dr. Zerbe hopes to be able to maintain his usual commit-
ments to students, teaching, and clients.
Jill Norris, PhD is stepping down as Section Head of Epidemiology and Community Health
effective January 31, 2006. She has been Section Head since April 1, 2002. Thanks to Jill
for her excellent leadership for the section and the department over these past years.
John E. Hokanson, PhD was selected as the new ECH Section Head effective
February 1, 2006. John has been Director of the Epidemiology PhD Program
since 2002. With his acceptance of the Section Head duties, he is relinquishing
half of his Epi PhD Director responsibilities and tasks.
Effective February 1, 2006, Dana Dabelea, MD, PhD started to serve as Co-
Director of the Epidemiology PhD Program. Dana will work with John for five
months and become sole Director as of July 1, 2006.
Current Research Grants
Principal Project Project
Investigator Title Start End Amount Sponsor
Barton HRSA P/H Traineeship 7/1/2005 6/30/2006 $9,236 HRSA
Baxter AHRQ E 6th R.M.W. 7/1/2005 6/30/2006 $187,159 AHRQ
Baxter CFPHE LDRSHP TRG.C 7/1/2005 6/30/2006 $15,000 CFPHE
Bryant CDC DISEASE - SIP 13-4 9/30/2005 9/29/2006 $58,999 CDC
Bryant CDC DISEASE - SIP9-05 9/30/2005 9/29/2006 $49,999 CDC
Bryant NCOA-Best Practices 8/15/2004 8/15/2005 $4,500 NCOA
Byers NIH SE Four Corners 8/1/2004 7/31/2005 Carryover NIH
Byers CDPHE Screen Prgm C 7/1/2005 6/30/2006 $165,225 CDPHE
Byers CDPHE Concord STY.FC 9/30/2004 9/29/2005 $50,820 CDPHE
Byers CCF STDY PELV DIS.FC 8/1/2005 7/30/2006 $124,660 CCF
Byers SGKBCF CANC REHAB LOW 5/1/2005 4/30/2006 $82,381 Komen
Byers DHH PATIENT NAVIG.FC 9/15/2005 8/31/2006 $193,000 Denver Hlth
Byers ACS SURVIVE LATINAS 1/1/2006 9/29/2006 $106,348 Am Canc S
Crane NIH SE SKIN CANCER 6/1/2005 5/31/2006 $589,791 NIH
Dabelea CDC WESTERN DIABETES 9/30/2004 9/29/2005 $537,180 CDC
Dabelea CDC SEARCH DIAB.YTH 9/30/2005 8/26/2006 $643,746 CDC
Dabelea NIH SE FETAL ORIGINS 9/14/2005 6/30/2006 $610,574 NIH
DiGuiseppi CDPHE MOTOR VEHIC.FC 9/30/2005 9/29/2006 $40,000 CDPHE
DiGuiseppi CSU G-7873 DiGUIS.FC 8/1/2005 7/31/2006 $88,941 CSU
DiGuiseppi CDC CDA: VAN BRAMER 8/30/2005 8/29/2006 $99,999 CDC
DiGuiseppi ACS PHYSICIAN TRINING 1/1/2003 12/31/2006 $300,000 ACS
DiGuiseppi ACS PHYSICIAN TRINING 1/1/2006 12/31/2009 $300,000 ACS
DiGuiseppi HRSA PREV.MED.PRGM 7/1/2005 6/30/2006 $164,509 HRSA
Fingerlin NJH BERYLLIUM EX.FC 7/1/2005 6/30/2006 $16,416 NJH
Fingerlin ADA IKKb-NF-kB PATHWY 1/1/2006 12/31/2006 $137,732 ADA
Glazner CDC E. CONST.INJURY 9/30/2005 9/29/2006 Carryover CDC
Glazner DUKE-BACK DISORDERS.FC 6/1/2005 5/31/2006 $19,219 Duke
Glueck NIH SE MAMMOGRAPHY 9/1/2005 8/31/2006 $135,974 NIH
Hamman USCRF.EX.DEP.FC 9/1/2005 8/31/2006 $43,005 USCRF
Hamman NIH DIABETES PREVENT 2/1/2006 1/31/2007 $496,006 NIH
Hamman NIH SE DEFINE DIABETES 8/1/2005 7/31/2006 Carryover NIH
Levinson UCD-NCI LATINO.FC 9/1/2005 3/31/2006 Carryover UCD
Leiferman AHRQ E MATERNAL DEPRESS 9/1/2005 6/30/2006 $67,201 AHRQ
Lezotte ED RESEARCH AND DEMO 10/1/2005 9/30/2006 $249,999 ED
Litt HUD-IMMIGRANT HSNG 10/1/2004 9/30/2007 $679,649 HUD
Litt HOPKINS HLTH GAP.FC 7/1/2004 9/30/2005 $48,862 Hopkins
Litt CSU HOUSING SAFETY 9/1/2004 7/31/2005 $14,975 CSU
Litt CDC ME PUBLIC HEALTH 9/30/2005 9/29/2006 $258,476 CDC
Litt DUG HEALTHY COMMUNITIES 10/1/2005 12/31/2005 $4,830 DUG
Marshall CSU ALA.CHILD NUTRIT 12/1/2004 6/30/2005 $17,862 CSU
Marshall NIH SE FAM.BASED PRE 9/1/2005 8/31/2006 $624,897 NIH
Marshall CDC DISEASE CORE 9/30/2005 9/29/2006 $735,817 CDC
Mueller CDC SFTY HLTH TRAIN 7/1/2005 6/30/2006 Carryover CDC
Mueller NIH OCC.TRAIN SPPRT 7/1/2005 6/30/2006 $90,000 NIH
Newman NJH BERYLLIUM DIS.FC 1/1/2006 8/31/2006 $134,705 NJH
Newman ORAU SCREEN PROGRM.FC 1/1/2006 11/30/2006 $334,483 ORAU
Newman NJH R01-SAGE.FC 1/1/2006 1/31/2006 $3,423 NJH
Newman NJH STUDY.SAGE.FC 2/1/2006 1/31/2007 $41,072 NJH
Current Research Grants
Principal Project Project
Investigator Title Start End Amount Sponsor
Norris USF DATA COOR CTR.C 9/1/2005 8/31/2006 $95,957 USF
Norris NIH SE AUTOIMMUNITY 9/1/2005 8/31/006 $550,159 NIH
Norris ADA VITAMIN D EFFECT 7/1/2005 6/30/2006 $97,328 ADA
Norris NIH SE FAMILY STUDY 1/1/2005 12/31/2005 $523,862 NIH
Rewers NIH SE PRE-DIABETIC 6/1/2005 5/31/2006 $769,914 NIH
Risendal SGKBCF-POP403288 5/1/2005 4/30/2006 $125,000 Komen
Risendal NIH MSE QUALITY OF LIFE 9/1/2004 8/31/2005 Carryover NIH
Risendal COLOSEM BRCA MUTATION 7/1/2005 6/30/2006 $48,118 DU
Ruttenber DOE ROCKY FLATS.C 4/1/2005 11/30/2005 $99,933 DOE
Snell-Bergeon AHA FELLOWS:S-B 1/1/2005 12/31/2005 $21,000 ASA
Drs. Larry Hunter and Susan Trapp of the Department of Pharmacology and Dr Dennis Lezotte of PMB are applying for a
National Library of Medicine (NLM) training grant for the Computational Biosciences Program (CBP).
Since the nature of biomedical research has evolved, the nature of our training must evolve along with it. The explosive
growth of post-genomic molecular biomedical knowledge, the rapid changes in technology, and the breakdown of disci-
plinary boundaries, present challenges to all contemporary biomedical training programs. Training in computational
biology is further complicated by the need to master two large and generally distinct bodies of knowledge and to develop
the skills necessary to communicate and collaborate effectively with diverse colleagues from disciplines spanning experi-
mental biology to mathematics to computer science. Computation is being integrated into the fabric of Molecular
Biology research at all levels, from the most basic data generation to the most elaborate communication of results.
Without inter-networked databases, sophisticated computational analyses and high fidelity simulations, many of the
most fundamental insights of modern molecular biology would be been beyond human reach. Still, the most exciting
integration of computation and molecular biomedicine is yet to come. Consequently, it is critical that the training of the
next generation of computational biologists be up to the daunting challenges that accompany this remarkable opportu-
nity. This training grant will allow us to adjust and adapt our existing bioinformatics train program and to also recruit the
best available students to the department’s newest PhD program by supporting 3 to 4 new PhD students per year for 4
years in the Bioinformatics track of the Analytical Health Sciences (AHS) degree program.
Faculty and Researchers Moving to Fitzsimons Campus
Tim Byers and his researchers in Cancer Prevention and Control have moved to a single location on the 4th floor east
of Building 500 at the Fitzsimons campus. This research group includes Lisa Hines, Jan Lowery and her group, Susan Rein,
Sarah Braudrick, Rebecca Sedjo and Holly Wolf, Dr. Betsy Risendal and her group and the Get R!EAL group. Dr. Steve Mark,
also has an office at the new location.
Susan Rein, Sarah Braudrick, Erin McIlnay and Holly carry out research on a variety of programs including the newly
awarded Colorado Colorectal Screening Program for the Underserved, the Colorado Colorectal Screening Awareness program,
and the SPORE in Lung Cancer.
The Cancer Center’s Get R!EAL staff are Sally Casey, Virginia Holland, Kristin Kidd, Natascha Palmer and Erin
Seedorf. Get R!EAL - Colorado’s Youth Movement Against the Tobacco Industry - is a youth advocacy movement supported
by a grant from the Colorado Department of Public Health and Environment. Get R!EAL stands for “Resist, Expose Advertising
Vicki Tosher, Project Coordinator, has also moved from the Office Annex to Fitzsimons to work with Betsy Risendal’s
group. SUNSHINE is an ACS funded study on Understanding and Improving Breast Cancer Survivorship in Latinas. It is a two-
site study using a cohort from the original SHINE (Southwest Hormone, Insulin, Nutrition, and Exercise) Study. SUN is for
Survivorship Update Network.
Updated contact information for these people, as well as new faculty and PRAs, is in the departmental telephone
listing, which can be found on our website http://pmb.uchsc.edu/, under Department, Excel Phone List. 5
Colorado Public Health Association
The Colorado Public Health Association presented its Roy Cleere Distinguished Service Award to Richard Hamman, MD,
DrPH. The Colorado Public Health Association’s Distinguished Service Award (established in 1965) was renamed in 1974
in honor of Dr. Cleere, who was the director of the Colorado Department of Health for 38 years. The award goes to
someone who has made an outstanding contribution to the association and to public health in Colorado.
Dr. Hamman was nominated for his leadership in public health, particularly for his efforts to obtain funding and other support
to establish a school of public health in Colorado. This award focuses on the leadership he has exercised in the last five years
to establish a school of public health in Colorado. Dr. Hamman convened leaders from the Colorado Department of Public
Health and Environment, Colorado State University, University of Northern Colorado, and the University of Colorado to
explore the need for and feasibility of a collaborative school of public health. Through his diligence, working groups have
developed a strategic plan for such a school, are developing administrators in the three university systems to secure their
interest and support, and hope to present their plans to all university officials and the Colorado Commission on Higher
Education later in the fall of 2005. Dr. Hamman had doggedly pursued his goal, even when the environment toward higher
education has appeared at best indifferent and at worst hostile.
The Colorado Public Health Association presented its Lifetime Achievement Award to Franklyn Judson, MD. The
Lifetime Achievement Award was established in 1996 to honor an individual who has retired from fulltime employment in
public health. It is awarded in recognition for their outstanding contributions and leadership in the field of public health.
Much earlier it had been decided to have the conference theme be “Mardi Gras”. Following hurricanes Katrina and Rita, it
was thought that this theme should be changed. However, one of the hurricane survivors suggested continuing with the
theme and collecting donations for the people of the affected areas. So in honor of those who have lost, donations were
collected and each donor was given a ticket for a prize drawing. All beads and prizes were purchased from Baton Rouge,
Tuesday, March 14, 2006
9:00 – 10:00 am in Room 1601
Steve Lowenstein, MD, MPH, Associate Dean for Faculty Affairs will present a “Promotions 101” session to our
department. This session is not just for junior faculty. Steve Lowenstein and Denny Lezotte, PMB Appointments &
Promotions Committee Chair, are encouraging all of our faculty to attend this session.
The past 20 departmental reviews indicate that many faculty members do not receive accurate information regarding
promotion (myths and misperceptions abound) and, based on two recent school-wide surveys, it is clear that many junior
faculty members do not understand the promotion rules that apply to them. It is our view that many faculty members
would benefit from a one-hour seminar devoted to promotion. Therefore, with the Faculty Affairs Office, the Depart-
ment of Preventive and Medicine has scheduled a one-hour “Promotion 101” course to be held Tuesday, March 14, 9:00-
10:00 am in Room 1601. All junior faculty should attend. Hopefully, chairs and senior faculty who are involved in
mentoring, faculty evaluations and promotion reviews will also attend.
to Jill Litt and her husband Ryan on the birth of their son Adrian Simon Gill on January 3, 2006!
He weighed in at 6 lbs 14 oz and 19 inches. Daughter Eden and parents are thrilled.
SECTION OF BIOMETRICS AND INFORMATICS
Katerina Kechris, PhD joined the Department of Preventive Medicine and Bio-
metrics in January as an Assistant Professor. She is also a core faculty mem-
ber of the Computational Bioscience Program at UCDHSC. Katerina received
her B.S. in Applied Mathematics from UCLA in 1997. After earning a doctoral
degree in Statistics from UC Berkeley in 2003, she was a Sloan Foundation/
DOE post-doctoral fellow in the Department of Biochemistry and Biophysics
at UCSF. Katerina investigates how information encoded in the genome speci-
fies patterns of gene expression and post-transcriptional processing. To an-
swer these questions, her research focuses on the development and applica-
tion of statistical methods for analyzing molecular sequences and high through-
put genomic data.
This past October Steven Mark, MD, ScD was appointed Professor in the
Biometrics and Informatics Section of our department. His previous position
was as Senior Research Investigator in the Biostatistics Branch, Division of
Cancer Epidemiology and Genetics, National Cancer Institute. There he
was principal investigator for a population cohort study in a region of China
with incidences of squamous esophageal and gastric cardia cancers. He
has published numerous papers investigating the effect of nutrient supple-
mentation on cancer incidence in this cohort, as well as on the association
of these cancers with serum nutrients, infections, and genetic polymor-
phisms. While at the NCI, a large part of his research involved developing
new statistical approaches to designing and analyzing these studies. This
research has been in the areas of time-to-event data, missing data, semi-parametric efficiency, and causal
inference. In his most current research he has proposed a formal probabilistic logic for enabling one to use
laboratory experiments as a basis of predicting what interventions will decrease cancer incidence in man. Dr.
Mark is a member of the translational research program at the Cancer Center. In conjunction with laboratory
and clinical investigators, he is developing new experimental designs whose goal is to increase the success
of pre-clinical research in identifying treatment and prevention measures that will subsequently prove benefi-
cial when tested in randomized intervention trials in humans.
Pam Wolfe joined the General Clinical Research Center in August 2004 as a
consultant, and was appointed to the position of Senior Clinical Instructor in
the Department of Preventive Medicine and Biometrics in October, 2005; 60%
of her support is provided by the GCRC. She teaches introductory biostatistics.
After receiving a Master of Science in Applied Mathematics from UCD in 1992,
Pam worked at AMC Cancer Research Center in the Biostatistics Core working
with behavioral and laboratory scientists. She worked as an independent
consultant for 5 years before joining the DPMB. Her areas of particular interest
are multivariate techniques, hierarchical models, power and sample size, and
SECTION OF EPIDEMIOLOGY AND COMMUNITY HEALTH
Lisa Hines, PhD has transferred to the Department of Preventive Medicine and Biometrics from
the Department of Pharmacology UCDHSC, which she joined in 2004. She received her B.S. in
Animal Physiology and Neuroscience from the University of California, San Diego. She then
attended the Harvard School of Public Health in Boston where she earned her doctorate in
Epidemiology, with a focus in the area of Molecular Epidemiology. In order to gain a better
understanding of molecular mechanisms involved in disease development, she did cross-disciplinary
post-doctoral training at the Harvard Institute of Proteomics, Harvard Medical School.
While at the Harvard School of Public Health, Lisa worked primarily with Drs. David Hunter and
Meir Stampfer to investigate gene-environment interactions that modify risk for complex diseases,
specifically cancer and heart disease. As a post-doc at the Harvard Institute of Proteomics, she
worked with Drs. Joshua LaBear and Joan Brugge to build and screen a large collection of breast
cancer-associated genes in order to investigate cellular pathways that may be involved in breast tumor initiation and progres-
Her research goals are to utilize her interdisciplinary training to identify unique strategies to elucidate the interacting genetic
and environmental factors that contribute to complex disease etiology and to apply this knowledge to implement more effective
disease prevention and treatment programs. She is primarily interested in the area of cancer. She is very excited to be joining
the faculty and looks forward to becoming a part of the department.
Jenn Leiferman joined PMB as an Assistant Professor in September of 2006. She received her
B.A. in Psychology from Texas A& M University; her M.S. in Kinesiology from University of North
Texas, and Ph.D. in Health Education from University of Texas at Austin. She also completed
NIH NRSA postdoctoral training at UNC at Chapel Hill in population studies and epidemiology.
Her current research interests lie in the area of maternal and child health, focusing on parenting
practices and their influence on child health outcomes. She has a strong interest in the effects
of parental mental health on certain parenting behaviors and practices associated with child
wellbeing. She is also currently working at designing ways to improve the detection and treat-
ment of maternal depression in primary care settings. She has published articles related to
maternal depression, parenting and health behaviors, and health services research.
Lee S. Newman, M.D., M.A., FCCP, FACOEM joined the Department of Preventive Medicine and
Biometrics as a Professor in January. He is also Professor of Medicine in the Division of Allergy and
Clinical Immunology and Division of Pulmonary Sciences and Critical Care Medicine at the University
of Colorado at Denver and Health Sciences Center. He is the former head of the Division of Environ-
mental and Occupational Health at National Jewish Medical and Research Center.
Dr. Newman conducts research on occupational lung and allergic disorders, pulmonary immunology,
toxicology, and granulomatous diseases. He is Co-Director of the Occupational and Environmental
Medicine Residency Program. For the past 20 years, his clinical practice has focused on occupa-
tional lung disorders. He consults internationally to government, industry and labor organizations on
occupational health in the workplace.
Dr. Newman completed his Bachelor of Arts degree from Amherst College and a Masters of Arts Degree in social psychology
at Cornell University Graduate School of Arts and Sciences. He earned his Medical Doctorate from Vanderbilt University
School of Medicine and completed his internship and residency in Internal Medicine at Emory University School of Medicine.
He completed his fellowship training in pulmonary medicine in 1986 at the University of Colorado Health Sciences Center and
at National Jewish, where he studied immunotoxicology and occupational and environmental medicine. Beginning during his
fellowship, Dr. Newman helped refine and apply a beryllium-specific blood-screening test, while conducting epidemiologic and
immunology research. His research has also focused on the relationship between genetics and environmental triggers for lung
disease, as well as studies on occupational asthma, silicosis, asbestos, environmental allergies, and radiation-induced lung
SECTION OF EPIDEMIOLOGY AND COMMUNITY HEALTH
Jan Lowery, MPH, PhD was promoted to Instructor in PMB in December, 2005, following completion of her PhD in Analytical
Health Sciences, Epidemiology from UCHSC. She received her MPH from UCLA in 1991, with a Concentration in Environmental
Health Sciences and Epidemiology. Jan has been a Senior PRA in the Cancer Center for the past 4 years. She has held
previous research positions at National Jewish, UC-Irvine Clinical Cancer Center and University of Southern California. Jan
manages several projects including two family-based cancer registries, and an intervention study to promote colon cancer
screening among high-risk individuals. Her primary research interests are in the areas of prevention and early detection of
cancer as well as educational outreach to individuals genetically predisposed to cancer.
Adrien Lohourignon Lokrou, MD, is a Professor at the School of Medicine of the University of Cocody,
Abidjan, Ivory Coast. He is also the Head of the Endocrine and Diabetes Division of the Teaching
Hospital of Abidjan-Yopougon. As many of you know, Dr. Lokrou is currently a Visiting Professor in
our Department. Dr. Lokrou is a Fulbright African Senior Research Scholar, and his program has
been funded by the Fulbright Board in Washington through the Council for International Exchange of
Scholars (CIES). The visit program will last 9 months, September 2005 to May 2006. Dr. Lokrou’s
research is focused on Diabetes.
In his clinical division at Abidjan, Dr. Lokrou has observed a new form of atypical diabetes in adult
subjects. That new entity is characterized by an impressive level of blood glucose at presentation; a
lack of ketosis related to mild hyperosmolarity and a transient kidney failure without history of renal
disease. The questions aroused are the following: 1) how can this new syndrome be classified? and 2) what is the
pathophysiological background of this new form of atypical diabetes? To answer these questions, its immunogenetic
features must be known through assessment of autoantibodies and HLA typing along with the insulin secretion status (C
Dr. Lokrou plans to develop a multicenter study on atypical diabetes in Africa, as well as a research network between African
and American researchers in the field of diabetes and other chronic diseases. He is very grateful to his host, Dr. Richard
Hamman, and all his colleagues and assistants.
H. Stela Dabelea, MD is a Visiting Assistant Professor from her internist/diabetologist practice at
the Emergency University Hospital in Bucharest, Romania. She is visiting us at HSC for about two
months. The purpose of her visit is to learn more about various aspects of the US Health Care
System and standards of medical practice.
She and her husband have a successful medical business in Romania and are now planning to
develop a private diabetes-obesity-cardiovascular prevention and treatment center in Bucharest,
one of the first such private centers in the developing Romania. She will visit the Barbara Davis
Center for Childhood Diabetes, A.F. Williams Family Center, Colorado Heart Imaging and various
hospitals and outpatients centers.
Thomas LaVeist, PhD, Professor of Health Policy and Management in the Bloomberg School of Public Health, The Johns
Hopkins University, and Founding Director of the Hopkins Center for Health Disparities Solutions, has been offered a Visiting
Professorship in the Department of Preventive Medicine and Biometrics for the summer semester 2006. The Visiting Scholar
Program is funded through a HRSA Preventive Medicine Training Grant awarded to Dr. DiGuiseppi. Dr. LaVeist’s research and
writing has focused on three broad research questions: 1) What are the social and behavioral factors that predict the timing of
health outcomes (e.g. access and utilization of health services)?; 2) What are the social and behavioral factors that explain
race differences in health outcomes?; and 3) What has been the impact of social policy on the health and quality of life of
African Americans? Dr. LaVeist seeks to develop an orienting framework in the development of policy and interventions to
address race disparities in health-related outcomes. Specific areas of expertise include: U.S. health and social policy, the role
of race in health research, social factors contributing to mortality, longevity and life expectancy, quantitative and demographic
analysis and access, and utilization of health services. During his term in resident, Dr. LaVeist will be teaching a graduate
course on “Cultural Competence in Organizations” July 10 through August 9. He has also agreed to provide the keynote
address for the School of Medicine’s Diversity Research Exchange, scheduled for May 4, 2006. 9
24th Annual Epidemiologic Research Exchange
Friday, February 24, 2006
The Epidemiologic Research Exchange is a forum for scientific exchange between
researchers in Colorado and nearby states. This forum provides an opportunity to
discuss ongoing research with other investigators interested in public health and
disease prevention. This year’s chair was Dana Dabelea, MD, PhD.
George Davey-Smith and Dana Dabelea Plenary Theme
“A Life Course Approach to the Study of Chronic Disease”
Dr. George Davey-Smith, MD, DSc, FRCP, Professor and Chair
of Clinical Epidemiology in the Department of Social Medicine at
the University of Bristol, UK. Dr. Davey-Smith studied medicine
at Oxford and Cambridge and completed a doctorate in Epidemiol-
ogy at the London School of Hygiene and Tropical Medicine. His
initial work focused on health inequalities between social class
groups and later on projects in child health and sexually transmit-
ted disease prevention in Nicaragua and India. Dr. Davey-Smith
moved to Bristol University as professor of clinical epidemiology in
1994, where his work focused on the early-life origins of adult
disease and, lately, genetic epidemiology. Since being in Bristol he
became co-editor of the International Journal of Epidemiology. He
is currently the Scientific Director of the ALSPAC study (Avon
Longitudinal Study of Parents and Children), a birth cohort study
that followed 14,000 youth up to age 15 years. His areas of
expertise extend from life-course epidemiology to genetic, nutri-
tional and social epidemiology. He has published over 500 peer-
reviewed articles, book-chapters and monographs.
More than 120 people attended this year’s Epi Exchange. There
were 15 oral presentations and 13 poster presentations.
The Epi Exchange is Sponsored By the Department of Preven-
tive Medicine and Biometrics at the University of Colorado at
Denver and Health Sciences Center; the Disease Control and
Environmental Epidemiology Division of the Colorado Department
of Public Health and Environment; and the Department of Envi-
ronmental Health at the Colorado State University.
Student Award Winner
Our student winner is Maggie L. Clark, a student in the Environmental & Radiological Health
Sciences Department at Colorado State University, specializing in Epidemiology. Her presenta-
tion, “A Cross Sectional Study of Residential Exposure to Radio-frequency Fields and Estrogen
Production Among Pre and Postmenopausal Women”, was selected by the Epi Exchange Review
Committee for this $100 award. The research she presented at the conference was a part of her
master’s project. Maggie is currently working on her dissertation research, “Indoor Air Pollution
and Adverse Health Among Honduran Women”, also at CSU. She received her BS from Miami
10 University in Ohio.
Min Hong graduated on August 19, 2005
Steve Russell graduated on December 16, 2005
Please note that the name of this Program has changed from Biometrics to Biostatistics. We feel this
title better reflects the Program’s educational focus.
Congratulations to Biostatistics MS Graduates!
These two students graduated August 19, 2005
Biostatistics MS Students accepted for the Spring Semester, which began January 23, 2006
General Preventive Medicine Residency Program
Dr. Lisa Van Bramer, a preventive medicine resident, received a New Investigator Award from the Centers
for Disease Control and Prevention on August 30, 2005, entitled, “Evaluating New Tools to Link Prehospital
and Hospital Injury Surveillance Data.” The goal of this project is to evaluate the use of geographic
information systems and other tools to improve linkages between prehospital traffic crash data and hos-
pital injury surveillance data. Dr. Art Davidson and Dr. Carolyn DiGuiseppi are her mentors on this award.
Dr. Carolyn DiGuiseppi, in collaboration with Dr. Tim Byers, was awarded a competitive renewal of the
Physician Training Award in Preventive Medicine from the American Cancer Society, in the amount of
$300,000, beginning January 1, 2006. This award supports resident training in cancer prevention and
control. Dr. DiGuiseppi will be giving a presentation about the training award at the Annual Program
Director’s Workshop at Prevention 2006 in Reno, Nevada on February 22, 2006.
Occupational & Environmental Medicine Residency Program
Carol Gunn graduated from this program 12-31-05
Sandra Buseman, who previously graduated from the preventive medicine program, joined us in October
for a practicum year
Welcome to two new Residents who will start in July!
Tracy Stefanon, who is moving from DC
Stella Hines, who is pursuing a combined pulmonary and occupational medicine residency
Public Health Traineeships
The MSPH program received $9,236 for the 2005-2006 academic year. The following MSPH students
are receiving monies from this traineeship grant:
The MSPH program just received word that we will again get monies from the Graduate School for
diversity awards. We have nominated four MSPH students to receive the funds for the spring semes-
ter 2006. They are:
The 2006-2007 academic schedule for the department will be up on the MSPH web page in April 2006.
The MSPH applicant interviews are scheduled for March 9 and 10, 2006. We look forward to having
two full days of interviews to help determine who among the applicants will start classes in the summer
or fall semester 2006.
The Council on Education for Public Health (CEPH) has scheduled a site visit April 24 and 25, 2006 as
part of the renewal on the MSPH accreditation. The visitors from CEPH will be George Kupfer, MS,
Chair, from Grayslake IL; Lowell Gerson, PhD, from Northeastern Ohio Universities College of Medicine;
and Mollie Mulvanity, MPH, CEPH Coordinator from Washington DC.
PhD Epidemiology Program
The Epidemiology Doctoral Program would like to welcome Dr. Dana Dabelea as the new program director
beginning in the summer of 2006. Dr. John Hokanson will serve as the co-director until that time. Dr.
Hokanson has accepted the position as Head of the Section of Epidemiology and Community Health for
our department. We look forward to collaborating with both of them in their new positions.
The Epidemiology Doctoral Program would like to congratulate and welcome two of our alumni to the
University of Colorado Health Sciences Center faculty. Dr. Jan Lowery has been appointed as an In-
structor in the Department of Preventive Medicine and Biometrics. She is based in the School of Medicine’s
Division of Cancer Prevention and Control and is working on the Fitzsimons campus. Dr. Kathleen Torkko
was appointed in the Department of Pathology as an Instructor. She has also been given a secondary
appointment in the Department of Preventive Medicine and Biometrics.
We would like to welcome Chris Lindley back from a two-year military leave of absence. Chris was admit-
ted into the program in the fall of 2003 and was deployed to Iraq in the beginning of 2004. We are
pleased Chris has returned safely to rejoin our program and his family.
Loretta Clark, PA-C has been working at the RMPRC in Alamosa since August 2005 in a temporary position as a data collector
for the School Environment Project. She will now be working as a Professional Research Assistant, beginning March 1, for the
Healthy Family Project doing phlebotomy and helping with clinics and other projects.
Loretta is a Physician Assistant, having graduated from the University of Colorado physician assistant program. She worked in
neonatal and pediatric medicine at the University of Tennessee Medical Center in Knoxville and at the University of New Mexico
Health Sciences Center in Albuquerque.
She was born and raised in Colorado before moving to Tennessee, where she lived for 22 years. Loretta happily returned to
Colorado to marry her husband three years ago. They live on her husband’s family farm, where he grows potatoes and barley.
She enjoys living near her family again, gardening in the summer months and downhill skiing in the winter.
Alice E. Franco joined PMB as a Professional Research Assistant on January 15, 2006. She received her MA from the
University of Denver in International and Intercultural Communication in 2001, with a Concentration on Immigration and Human
Rights. She received her BA from Trinity University in San Antonio TX. She has had language training in Spanish at the
Instituto Falcon in Guanajuato, Mexico and the Casa de Español Xelaju in Quetzaltenango, Guatemala. She studied French
at the University of Strasbourg, France. Alice is working as a Volunteer and Educational Program Specialist with Patricia
Valverde and Betsy Risendal on an Avon-funded project for outreach to breast cancer survivors.
Ray Kasel transitioned from the Department of Occupational Medicine at National Jewish in Feb-
ruary 2006. Ray will be serving as a Senior Professional Research Assistant with Dr. Lee Newman.
The core focus of Ray’s duties will include database implementation and administration, program-
ming, server implementation and administration as well as Web Development.
For perhaps his amusement only, Ray enjoys publishing animations and comic strips on the web.
Just Google his name and you may find some of them.
Wendy Peters Moschetti joined PMB in January 2006 as a Professional Research Assistant.
Wendy will be working with Dr. Jill Litt as Project Coordinator for the Gardens for Growing Healthy
Communities project (www.gghcdenver.org). Wendy earned her Master’s in City Planning at UC-
Berkeley in 2003, and prior to moving to Boulder and accepting this position she worked as a
consultant in collaborative strategic and policy planning for 2 years in the Bay Area. As an under-
graduate studying Social Work in the late 1990s, Wendy’s interest in food security issues and
community gardening first led her to urban planning, and she is thrilled to be involved with a project
that brings aspects of health, nutrition, and activity together with the social and built environment.
Wendy and her husband Morgan, a PhD student at CU-Boulder, are enjoying being back in Boulder
where they love that they can walk to everything they need, and enjoy trail running and backcountry
skiing as much as possible, when not at home cuddling with their 2 cats.
Susan M. Rein, BSN RN has been a Clinical Research Coordinator at UCDHSC since March 1997. As of July 2003, she has
been splitting her time between Preventive Medicine & Biometrics and the Department of Gastroenterology. March 1, she
started working fulltime for PMB with Tim Byers’ research group, working on two Colorectal Screening Programs. Susan
earned her Bachelor of Science in Nursing from the University of Colorado Health Sciences Center in 1995.
Holly Sackett joined the Department of Preventive Medicine and Biometrics in February 2006 as a Senior Professional Re-
search Assistant for Dr. Lee Newman. She is a MSPH graduate and is excited to be part of the department. Prior to accepting
this position, she was an epidemiologist at National Jewish Medical and Research Center studying chronic beryllium disease. 13
Amanda Jean Stevenson joined PMB in November 2005 as a Professional Research Assistant working with Jessica Bondy
and Judy Glazner on a cost analysis of a nurse home visitation study. Before bravely moving to cold, cold Colorado, Amanda
worked for the State of Washington on a series of project evaluations. On rare and cherished weekends, Amanda also enjoys
working as a surly breakfast waitress.
In addition to serving up eggs and data, Amanda spends her time playing bridge, playing old-time music and playing with her
sewing machine. Amanda has two delightful dogs and a lovely boyfriend.
Heidi Strike joined PMB in December 2005 as a Professional Research Assistant for the SEARCH for Diabetes in Youth Study.
Heidi earned her BS in Biology at the University of Colorado at Denver in 2003. After college she worked as an assistant for a
blind medical student, as an information provider for Rocky Mountain Poison and Drug Center and as a donor technician for
Bonfils Blood Center. Heidi volunteers at Children’s Hospital once a week as a patient representative and enjoys all outdoor
Nicole Sucre joined PMB in January of 2006 as a PRA for the EPOCH study. She has recently moved back to her hometown
of Denver after completing her master’s degree and doctoral coursework in Clinical Psychology in San Francisco. Her clinical
and academic interests include health psychology (chronic illnesses, maternal and child health) and affect regulation, PTSD,
depression, addictions and eating disorders. Her dissertation topic is a program evaluation of the mental health components
of an infant mortality reduction project.
Nicole is married, has an (already?!?) ten year old son, two dogs and a cat. She enjoys laughing, talking, cooking, hiking,
playing and otherwise hanging out with her family, and also enjoys yoga and is a compulsive bibliophile. She and her husband
aspire to learn salsa (perhaps when the dissertation is done?), but for now amicably settle for the laughter and smiles they
bring to themselves and others as they trip over one another when they try.
Brian Tooker joined the Department of Preventive Medicine and Biometrics in January as a Senior
Professional Research Assistant working under Dr. Lee Newman. Brian received his BS in Microbiol-
ogy in 2000 and his MS in Animal Science in 2003, both from Michigan State University, where the
major focus of his research was centered on bacterial/ host interactions, genomics and proteomics.
After successfully defending his MS thesis Brian accepted a position as an Assistant Scientist II/
Laboratory Manager at Iowa State University where he worked under Dr. Tim Stahly. For the next year
and half Brian used his unique skill set to help set up a molecular based laboratory to study the effects
of diet composition on animal growth and development at a molecular level. In September of 2005
Brian accepted the position of Laboratory Researcher V in the DEOHS laboratory of Dr. Lee Newman
where he began his investigation of Chronic Beryllium Disease, an investigation that he continues at
UCHSC. In his free time Brian is an avid downhill skier, voracious reader and passable poker player.
Brian also enjoys working with his hands and has taken up several pastimes such as cooking, baking,
wood working, candle making and stained glass.
Joanne Madrid Vermeulen has joined the Department of Preventive Medicine and Biometrics and is working as a Professional
Research Assistant for the “SEARCH for Diabetes in Youth” study. She was previously employed by UCDHSC as a Project
Manager for an NIH funded cancer research grant through the Colorado Front Range Latino Community Network, with the
Latino/a Research & Policy Center.
Joanne has a BA from the University of Wyoming with majors in both Psychology and Social Science and has a professional
interest in health issues surrounding underserved populations. Before coming to UCHSC, she had been employed as an IT
project manager, grant researcher/writer, social worker, medical assistant, and an aviation mechanic.
Xiang Yin joined the Department of Preventive Medicine and Biometrics in January 2006. She works as
a data analyst for Dr. Jill Norris’ IVY diabetes study and Dr. Tim Byers’ various cancer studies. Currently
she is also a graduate student in the Biostatistics Program.
Xiang Yin grew up in Beijing, P.R. China and has lived in Colorado since 1997. She received a M.S.
degree in Physiology and Biophysics from UCHSC in 1998 and then worked in an immunology research
lab in National Jewish Medical and Research Center for five years. Now she is very excited to work in the
14 area of biostatistics and looks forward to making a difference in various research projects.
Dr. Wendi Dick, who graduated from the General Preventive Medicine Residency Program on June 30, 2005,
was selected as a Diplomacy Fellow by the American Academy for the Advancement of Science. She accepted a
placement at the Department of State working on Iraq reconstruction, where her duties include oversight of the
water/sanitation and health reconstruction sectors, ministerial capacity development, and related issues.
The Epidemiology Doctoral Program would like to congratulate and welcome two of our alumni to the University
of Colorado Health Sciences Center faculty. Dr. Jan Lowery has been appointed as an Instructor in the Depart-
ment of Preventive Medicine and Biometrics. She is based in the School of Medicine’s Division of Cancer
Prevention and Control and is working on the Fitzsimons campus. Dr. Kathleen Torkko was appointed in the
Department of Pathology as an Instructor. She has also been given a secondary appointment in the Department of
Preventive Medicine and Biometrics.
Amongst the most recent graduates from the Graduate Program in Biostatistics for whom we have current em-
ployment information, Melanie Bell is a Lecturer in the Department of Preventive and Social Medicine at the
University of Otago in Dunedin, New Zealand. David Weitzenkamp is a Research Statistician with RTI Interna-
tional in Research Triangle, North Carolina. Heather Orton is a graduate student in Epidemiology at the Univer-
sity of Colorado Health Sciences Center. Lening Zhang is an Assistant Professor at the National Jewish Medical
and Research Center. Misoo Ellison is an Assistant Professor at the National Jewish medical and Research
Center. Greg Laberge is a forensic officer in the Denver Police Department. Janet Tooze is an Assistant
Professor at Wake Forest University School of Medicine in Winston-Salem, North Carolina. Susan Mikulich is
an Assistant Professor in the Department of Psychiatry at the University of Colorado Health Sciences Center.
Zhaoxing Pan is a Senior Biostatistician at the Center for Children, Families and Communities in Denver, and
Bonnie LaFleur is an Assistant Professor at Vanderbilt University.
ALUMNI — we would like to stay in touch with you
We would like to know what’s going on with our alumni, but sometimes we fall out of touch. As people move on
to new opportunities, it’s easy to lose track of them. One way we have of staying in touch is through this news-
letter. As well as keeping you informed of what’s going on in the Department, we would like to publish what’s
going on with you. Please take a few minutes to email us with where you are now, what you’re doing, what’s
happening with your family, what you do for recreation, etc. Photos are welcome too. We’ll publish the infor-
mation in our next issues. Currently the newsletter is published twice per year.
We would like to be emailing our newsletter, rather than sending it by snail mail. Via email, you see the photos in
color, it’s a quicker and simpler way of communicating, and each issue can have more information in it since there
are not printing and postage limitations. If you have an email address update, please send your contact informa-
tion to the Program that graduated you -- Fayette.Augillard@uchsc.edu (Biostatistics and Bioinformatics
programs, residency programs), Annette.Hays@uchsc.edu (MSPH program), Jennifer.Seifert@uchsc.edu (Epi
PhD program) -- or Debra.Becker@uchsc.edu (newsletter editor). Thank you.
UCDHSC - Preventive Medicine and Biometrics
4200 East 9th Avenue
Campus Box B-119
Denver, CO 80262
Would you like to be notified when a new issue of this newsletter is on the
website, rather than receiving a paper copy? Please send a note and your email
address to Debra.Becker@uchsc.edu to make that happen.
U.S. Public Health Service Professional Conference
May 1-4, 2006 — Adam’s Mark Hotel — Denver CO
The U.S. Public Health Service Professional Conference is the pre-eminent event of its kind in the nation
offering an incomparable range of continuing education seminars on the latest trends and innovations in
public health care delivery, administration and research. Join them in the Mile High City for four days of
informative and thought-provoking educational sessions featuring national and international speakers. Stay
up-to-date on emerging trends and important issues in public health care. As always, the conference will
include a full day of profession-specific topics. Details available at http://www.coausphsconference.org/.
Just Announced ADM John Agwunobi, the recently-confirmed Assistant Secretary for Health to deliver
Luther Terry Lecture.
Learn more about the recently-announced Public Health Leadership Institute, which will precede the con-
ference, at http://www.coausphsconference.org/LeadershipInstitute.cfm