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The Next Step in Aging Research


									The First Annual Mayo Clinic Robert and
Arlene Kogod Center on Aging Conference

The Next Step in
Aging Research:
From Bench to Bedside
A Forum for Collaboration
Between Clinicians and Researchers

                  June 17-20, 2010
                  The St. James Hotel
                  Red Wing, Minnesota
           GeneRAl InFoRmAtIon
conference director                                Lifespan in Aging Research
James Kirkland, M.D. Ph.D., Mayo Clinic          • Frailty in Humans and Animals
                                                 • Models of Delayed or Accelerated
conference Organizing committee                    Aging
Edward Arriaga Ph.D.,                            • Large-Scale Research Approaches
 University of Minnesota                           for Enhancing Healthspan
Holly Brown-Borg Ph.D.,                          • Potential Therapeutic Targets
 University of North Dakota                      • Panel Discussion: Next Steps in
Sundeep Khosla M.D., Mayo Clinic                   Integrating Basic Biology of Aging
Sreekumaran Nair M.D. Ph.D., Mayo Clinic           and Clinical Geriatrics
Tamara Tchkonia Ph.D., Mayo Clinic
Jan van Deursen Ph.D., Mayo Clinic             Registration
                                               To register, complete the attached
conference Overview                            registration form and return by mail or
The objective of our meeting is to             fax. You may also register by sending an
create a forum to bring together basic         e-mail to
researchers in aging and clinical              Registration includes the conference
geriatricians to promote the translation       meals and social activities. A letter of
of new findings in the basic biology of        confirmation will be sent upon receipt
aging in order to increase healthspan.         of a completed registration form. Please
                                               note that all participants planning to
The meeting will involve 30 minute talks
                                               attend any portion of the meeting must
by internationally renowned speakers
                                               register as an attendee. Space is limited
on aging research followed by time for
                                               to the first 100 registrants.
discussions. Sessions will be organized
around specific themes. The meeting will
commence with an evening welcome
                                               Registration Fee
                                               In the interest of promoting attendance
reception followed by a keynote
                                               and collaboration the inaugural
address. The following two days will be
                                               conference fee will be waived.
dedicated to the scientific presentations.
There will also be an opportunity for
poster presentations.                          cancellations
                                               To cancel, please send an e-mail to
Topics addressed will be relevant to the
translation of basic biology of aging to
the clinic: latest findings in basic biology   conference location and date
of aging, animal models, what clinicians       The first annual Mayo Clinic Robert
want, and potential interventions.             and Arlene Kogod Center On Aging
The aims of the meeting will be:               Conference The Next Steps in Aging
  • Provide a forum to outline findings        Research: From Bench to Bedside will be
    in the basic biology of aging and          held on June 17-20, 2010 at the St. James
    discuss how they might relate to           Hotel in Red Wing, Minnesota.
    clinical practice.                         Red Wing - a distinctive destination
  • Foster links between basic                 The city of Red Wing was named one of
    research practitioners and clinical        the top 12 distinctive destinations in the
    geriatricians.                             United States by the National Trust for
  • Facilitate interaction of established      Historic Preservation in 2008.
    investigators with junior-level  
    investigators, both basic scientists
    and clinicians.                            hotel Accommodations
                                               Lodging arrangements are the sole
Program Topics                                 responsibility of the individual
  • Wellness, Healthspan, and Frailty          registrant. A limited number of guest
    as Considerations in Addition to           rooms have been reserved for attendees
          GeneRAl InFoRmAtIon
and their guests at each of the following      Ronald Petersen, M.D., Ph.D.
Red Wing hotels. In order to receive a           Cora Kanow Professor of Alzheimer’s
discounted rate, reservations must be            Disease Research
made before the room block is filled or        Heidi Scrable, Ph.D.
before the expiration date of May 17,          Eric Tangalos, M.D.
2010, whichever comes first. Reservations      Tamar Tchkonia, Ph.D.
will be taken following this date based on     Jan van Deursen, Ph.D.
space and rate availability. Please identify     Vita Valley Professor in Cellular
yourself as a participant of the Aging           Senescence
Conference, From Bench to Bedside              Guest Faculty
when making your reservation.                  Albert Einstein College of Medicine
The St. James Hotel                            Nir Barzilai, M.D.
(conference location)
                                               Barshop Institute for Longevity and Aging
406 Main Street
                                               Studies, University of Texas San Antonio
(phone) 651-385-5547, (fax) 651-388-5226
                                               Steven Austad, Ph.D.
                                               Yuji Ikeno, M.D., Ph.D.
$159.00 single/double
                                               James Nelson, Ph.D.
Nichols Inn of Red Wing
1750 Hwy. 61                                   Boston University
(phone) 651-388-6633                           Thomas Perls, M.D.                    Brown University             John Sedivy, Ph.D.
$72.90 (Thursday)                              Marc Tatar, Ph.D.
$84.90 (Friday & Saturday)
                                               Buck Institute for Aging Research
Country Inn & Suites By Carlson                Judy Campisi, Ph.D.
4275 Highway 61 West
(phone) 651-388-9000, (fax) 651- 388-9009      Groningen University, The Netherlands                  Gerald de Haan, Ph.D.                        Folkert Kuipers, Ph.D.
$80 standard room
                                               Harvard Medical School
Transportation Information                     David Sinclair, Ph.D.
Red Wing is located approximately
                                               Hennepin County Medical Center
1 hour South East of the Minneapolis/
                                               Chronic Disease Research Group
St. Paul International Airport and
                                               Anne Murray, M.D., MSc
approximately 50 minutes North East of
Rochester MN.                                  Maine Medical Center Research Institute
Faculty                                        Clifford Rosen, Ph.D.
Mayo Clinic                                    Newcastle University for Ageing and
Eduardo Chini. M.D., Ph.D                      Health, United Kingdom
Gregory Hanson, M.D.                           Thomas von Zglinicki, Ph.D.
James Kirkland, M.D., Ph.D.
   Noaber Foundation Professor of Aging        Southern Illinois University
   Research                                    Andrej Bartke, Ph.D.
Nicholas LaRusso, M.D.                         University of Kentucky
   Charles H. Weinman Professor                Charlotte Peterson, Ph.D.
Joseph Lustgarten, Ph.D.
Sreekumaran Nair, M.D., Ph.D.                  University of Michigan
   David H Murdock – Dole Food                 Richard Miller, Ph.D.
   Company Professor of Nutrition Science
University of Minnesota                     10:45 – 12:45 pm
Edward Arriaga, Ph.D.                       Scientific Session #2
Huber Warner, Ph.D.                         Chair, Dr. James Kirkland
                                            Co-Chair, Dr. Charlotte Peterson
University of North Carolina
at Chapel Hill
                                            Dr. Judy Campisi
Jan Busby-Whitehead, M.D., Ph.D.
                                            Senescent Cells: A Link Between Aging,
                                            Inflammation, and Age Related Disease?
University of North Dakota
                                            Dr. John Sedivy
Holly Brown-Borg, Ph.D.
                                            Evidence for in vivo
VitaValley                                  Cellular Senescence in Mammals
Technical University Eindhoven              Dr. Thomas von Zglinicki
University Maastricht                       Understanding Cell Senescence as a Basis
Maarten Verkerk, Ph. D.                     for Intervention

                                            1:00 – 3:00 pm
                                            Lunch and River Boat Tour
                                            3:00 – 4:30 pm
THuRSday, JuNe 17, 2010                     Free Time
5:00 – 7:30 pm
Meeting Registration and Reception          4:30 – 6:00 pm
                                            Poster Session
7:30 – 8:30 pm
George Randolph and Patricia Scott          6:00 – 7:30 pm
Lectureship On the Physiology of Aging      Dinner
Dr. Huber Warner, University of Minnesota
The Longevity Dividend: Studying            7:30 – 9:30 pm
Chronic Disease Through Biogerontology      Scientific Session #3
Chair, Dr. Cliff Rosen                      Chair, Dr. Marc Tatar
Co-Chair, Dr. Nicholas LaRusso              Co-Chair, Dr. Eric Tangalos

8:30 – 10:00 pm                             Dr. Jan Busby-Whitehead
Social Reception                            TBA
                                            Dr. Heidi Scrable
Friday, June 18, 2010                       Early Life Events that Impact
7:30 – 8:30 am                              Healthspan and Frailty in Late Life:
Breakfast                                   the Role of p53
                                            Dr. Jan van Deursen
8:30 – 10:30am                              Mosaic Variegated Aneuploidy
Scientific Session #1                       Syndrome: A New Human
Chair, Professor Folkert Kuipers            Progeriod Syndrome?
Co-Chair, Dr. Joesph Lustgarten
                                            9:30 – 11:00 pm
Dr. Nir Barzilai                            Reception
Dr. Thomas Perls
Medical and Genetic Characteristics
of Centenarians
Dr. Gregory Hanson
A Clinician’s View of the Frail Patient

10:30 – 10:45 am
SaTuRday, JuNe 19, 2010                    7:00 – 8:00 pm
7:30 – 8:30 am                             Panel Discussion: Next
Breakfast                                  Steps in Integrating Basic Biology of
                                           Aging and Clinical Geriatrics
8:30 – 11:10 am                            Moderator: Dr. Jan Busby- Whitehead,
Scientific Session #4                      Dr. Judy Campisi, Dr. Rich Miller,
Chair, Dr. Holly Brown- Borg               Dr. Anne Murray. Dr. Maarten Verkerk
Co-Chair, Dr. Yuji Ikeno
                                           8:00 – 9:30 pm
Dr. Andrzej Bartke                         Dinner
Growth Hormone, Insulin and Aging
Dr. Richard Miller                         9:30 – 10:00 pm
Stress Responses in Long-Lived Mutant      Closing Remarks
Mice: From Cultured Fibroblasts to Mice-
on-the-Hoof                                10:00 pm
Dr. David Sinclair                         Return to Red Wing
Investigations into the biology of the
lesser known sirtuins                      SuNday, JuNe 20, 2010
Dr. Eduardo Chini                          7:30 – 10:00
How does resveratrol activate SIRT1?       Breakfast and Departure
The tale of three (proteins) Musketeers    *tentative schedule subject to change

11:10 – 11:15 am
Break                                      call for Abstracts
                                           Mayo Clinic Robert and Arlene Kogod
11:15 – 1:15 pm                            Center on Aging invites abstracts to
Scientific Session #5                      be considered for presentation at the
Chair, TBA                                 conference The next step in Aging
Co-Chair, Dr. Edward Arriaga               Research: From Bench to Bedside which
                                           will be held on June 17-20, 2010 in Red
Dr. Gerald de Haan                         Wing, MN. Abstracts describing research
Aging of hematopoietic stem cells: a       results related to the conference theme
genetic program or random noise?           are particularly encouraged.
Dr. Steven Austad
                                           Three travel awards are available
Dietary Restriction: A Zoological/
                                           for outstanding abstracts, covering
Evolutionary Perspective
                                           travel and accommodation costs for
Dr. James Nelson                           the conference. Award recipients will
TBA                                        be invited to present his/her research
                                           during the closing session. Additionally
1:15 – 2:30 pm                             some submitted abstracts may be
Lunch                                      selected for presentation as a short talk.
                                           Please mark your abstract as “poster
2:30 – 3:30 pm                             only” if you DO NOT wish to be
Oral Poster Presentations                  considered for such a slot.

4:30 – 6:00 pm
Travel to Mayo Clinic in Rochester
(Transportation provided)

6:00 – 7:00 pm
Reception in Mayo Clinic
Gonda Building
Program Topics are:                         Information on the Mayo Clinic Robert
     Wellness, Healthspan, and Frailty      and arlene Kogod Center on aging
     as Considerations in Addition to       Mayo Clinic Robert and Arlene Kogod
     Lifespan in Aging Research             Center on Aging is an innovative center
     Frailty in Humans and Animals          where education, research, and practice
     Models of Delayed or Accelerated       come together to improve the quality of
                                            life from birth to end of life. The goal of
     Large-Scale Research Approaches
                                            the center is to discover ways to delay
     for Enhancing Healthspan
     Potential Therapeutic Targets          the onset of age-related diseases and
     Panel Discussion: Next Steps in        disabilities and, if they do occur, to find
     Integrating Basic Biology of Aging     ways to make them more manageable.
     and Clinical
     Geriatrics                             The Kogod Center on Aging
                                            encompasses clinicians and scientists
abstract Submission Guidelines
                                            from all departments at Mayo Clinic’s
Abstracts must be saved in Word or pdf
                                            three campuses, in Arizona, Florida and
format limited to one page and must be
sent as attached files by e-mail to Tamar   Minnesota. These unique collaborations
Tchkonia, Ph.D., at tchkonia.tamar@mayo.    are unlike anywhere else and lead to
edu no later than April 30, 2010. We        innovative ways of studying aging.
encourage you to submit early to ensure     Programs being developed in the
prompt confirmation and                     center involve cellular senescence,
processing.                                 independent living, aging bone, joint
                                            and muscle, metabolic disease and
Abstracts should contain the following
                                            hormone regulation, and progenitor and
content sections:
        Background, Objectives,             stem cells. These programs will bridge
        Methods (including type of data     the gap between basic science and
        collected)                          clinical application, allowing us to better
        Results, Conclusions, and           understand aging and how to improve
        Support (if applicable)             the entire life cycle.
        Underline name of presenting
        author, list co-authors and
        collaborators, your department,
        institution, city, country, and
        postal code
You will receive an e-mail
acknowledgment of each abstract
submission. If you DO NOT RECIEVE
an e-mail acknowledging submission,
contact Dr. Tamar Tchkonia at tchkonia.

Posters should be no more than 4 feet
high and 4 feet wide.

For more information on the conference
please contact:

The Mayo Clinic Robert and Arlene
Kogod Center on Aging
phone: 507-266-9151
The First Annual Mayo Clinic Robert and Arlene Kogod Center on Aging Conference
The Next Step in aging Research: From Bench to Bedside
The St. James Hotel • June 17-20, 2010 • 400 Main Street • Red Wing, Minnesota 55066
Mail or fax form to:
The Mayo Clinic Robert and Arlene Kogod Center on Aging                         Phone 507-266-9151
Guggenheim 7-01                                                                 Fax 507-293-3853
200 First Street SW                                                             E-mail
Rochester, MN 55905
                          Web site:

Contact Information
Name of Registrant – first name, middle name or initial, and last name          Degree – select all that apply
                                                                                  MD        PhD         DO         PA        NP
                                                                                  Other - specify
Name of Institution                                                             Medical Specialty

Preferred Mailing Address – select one            Work/Business              Home
Work/Business Address – street address                                        Work Phone – include all country and city/area codes
                                                                                as needed along with complete phone number

City                                                   State or Province        ZIP or Postal Code Country

Home Address – street address                                                   Home Phone – include all country and city/area
                                                                                codes as needed along with complete phone number

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E-mail Address                                         FAX – include all country and city/area codes as   FAX Location – select one
              If you have special assistance needs or dietary restrictions, describe here:

Opening Reception (Thursday, June 17)
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Total Number Attending            ___

Mississippi River Cruise with Lunch (Friday, June 18)
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Total Number Attending              ___

Riverboat Cruises on the mississippi River
“Pearl of the Lake” is a modern day replica of the grand riverboats that traveled on the Mississippi River in
the 1800’s. True to tradition, her only means of propulsion is the twin paddlewheels in the stern. Her name
emphasizes the historic significance shared by paddlewheel boats and the freshwater pearl industry on the upper
Mississippi River. The mussels that produce fresh water pearls are very sensitive to pollution and an important
indicator of water clarity. It is our mission to help educate people about the history and environmental factors that
impact our great River

Mayo Clinic Dinner, Rochester MN (Saturday, June 19) - transportation will be provided
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Total Number Attending            ___

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