The UNM Research Enterprise Tran

Document Sample
The UNM Research Enterprise Tran Powered By Docstoc
					The UNM Research
    Enterprise:
Translating Science
 to Medical Cures



  Richard S. Larson, M.D., Ph.D.
 HSC VP for Translational Research
SOM Sr. Associate Dean for Research
           Overview
  •   Goal/Vision
  •   Growth
  •   Strategy & Organization
  •   Scientific Highlights
  •   Commercialization Effort




HEALTH SCIENCES CENTER
                Goal/Vision
• The goal of the UNM HSC is to accelerate the
  translation of scientific discovery to improved
  health.
• We will achieve this by creating a platform that
  transforms research at UNM into a continuum
  extending investigation from discovery into
  practice, thereby linking even the most basic
  research to practical improvements in human
  health.



     HEALTH SCIENCES CENTER
         Strategies:

 • Programmatic Grants
 • Clinical Trials growth
 • Diversification of Portfolio




HEALTH SCIENCES CENTER
                        Growth of UNM HSC Research Funding
                      Compared to Growth of NIH Research Funding

                                                                                                 2008:
                             600
UNM HSC Research Funding



                                                                                              $134 Million
 (Percent of 1990 Dollars)



                             500

                             400
                                                                             UNM
                             300            1990:
                                          $25 Million
                             200
                                                                               NIH
                             100

                              0
                                   1990            1995             2000             2005
                                                             Year
                                    Source for NIH Data: http://www.aaas.org/spp/rd/cht9005a.pdf

                             HEALTH SCIENCES CENTER
                     Translating Discovery into Medical Practice

     Bench                                                                                Bedside                 Community
                                      BEDSIDE

                                   Human Clinical
                                                                                                     6 Signature Research Programs
                                     Research
     T1
Case Studies
                                Controlled Observational
                                         Studies
                                                                                          T2/T3
                                                                           Practice-Based Research
                                                                                Phase 3 and 4
                                                                                                     • Brain and Behavioral
Phase 1 and 2
Clinical Trials
                                 Phase 3 Clinical Trials                         Clinical Trials
                                                                            Observational Studies      Illnesses
                                                                               Survey Research

                                                                                                     • Cancer
                                                                                                     • Cardiovascular and
          Basic Science
            Research
                                                            Clinical Practice
                                                                                                       Metabolic Diseases
                                                       Delivery of Recommended Care;


                                                                                                     • Environmental Health
                                                        Right Patient at the Right Time
          Preclinical Studies
                                                         Identification of New Clinical
          Animal Research                                Questions and Gaps in Care




   BENCH                                                                 PRACTICE                    • Infectious Diseases and
                                                                                                       Immunity
                                            Conceptual Process of
                                          Bench to Bedside to Practice
                                                                                                     • Child Health Research
                                                   Research

                            HEALTH SCIENCES CENTER
P & U Submissions & Received Data
                  FY   FY   FY   FY
                  2006 2007 2008 2009
U - Submissions   20   25   39   6
U - Received      18   32   32   11
P - Submissions   6    5    8    1
P - Received      5    5    7    2




    HEALTH SCIENCES CENTER
         Recent programmatic grants
•   Infectious Disease & Immunity        •   Children’s Health
     – Pulmonary Responses to                 – Prevention Research Center
       Bioweapon Category A                   – Treating Children to Prevent
       Pathogens                                Exacerbations of Asthma (TREXA)
     – Hantavirus Ecology and Disease
       in Chile and Panama
                                         •   Brain & Behavioral Illnesses
                                              – Integrative Program in CNS
•   Cancer                                      Pathophysiology Research
     – University of New Mexico Cancer        – Fetal Ethanol-induced Behavioral
       Center Support                           Deficits: Mechanisms, Diagnoses,
     – University of New Mexico Center          and Interventions
       for Molecular Discovery
                                         •   Cardiovascular and Metabolic
•   Environmental Health                     Diseases
    Sciences                                  – Diabetes Prevention Program
     – Genetics of Kidney Disease in            Outcomes study
       Zuni Indians                           – INBRE




           HEALTH SCIENCES CENTER
    BRAIN AND BEHAVIORAL ILLNESS
         SIGNATURE PROGRAM
•        Brain injury
     –      Stroke
     –      Trauma
     –      Immune-mediated brain disorders
     –      Dementia, movement disorders, epilepsy, critical care neurology
•        Addictive behavior
     –      Alcohol and substance abuse
•        Schizophrenia
•        Neurodevelopmental disorders
     –      Fetal alcohol spectrum disorder
     –      Autism spectrum disorders
     –      Heavy metal exposure
     –      Cerebral palsy
•        Technology Development
     –      Advanced MRI technologies: spectroscopic imaging, metabolite
            diffusion, real-time fMRI
     –      Magnetoencephalography
     –      Continuous cerebral blood flow measurement in the ICU
     –      Brain slice electrophysiology and combined fluorescence imaging


HEALTH SCIENCES CENTER
    Cardiovascular and Metabolic Diseases
•    Mission - To enhance the opportunities for research in Cardiovascular and Metabolic Diseases at the University of
     New Mexico by facilitating collaborative inter-disciplinary scientific interactions and discussions, supporting the study of
     new ideas and fostering the development of new investigators.

•    Strategic organization to address national trends - Areas of research include basic science, clinical and
     translational studies focusing on:
       – Cardiovascular Disease (Leading cause of death in NM residents; 11.7% of population nationally diagnosed with
           CV disease)
       – Diabetes (9% of the NM population has diabetes compared to 7% nationally; 2-3X higher incidence in Native
           Americans and Hispanics)
       – Obesity (57% of NM adults are considered overweight or obese compared to 32% nationally)

•    Alignment with Training programs
      –    Cardiovascular Biology Training Grant for graduate students and postdoctoral fellows (17th year of funding)
      –    CTSC pilot projects and scholars program

•    Integration of basic, clinical and translational Sciences - Numerous collaborative interactions exist. i.e.
     Studies of cytokine-induced protein catabolism in vitro subsequently examined in patients with chronic kidney disease
     leading to studies examining the effectiveness of blocking cytokine activation in dialysis patients. examining the
     effectiveness of blocking cytokine activation in dialysis patients.

•    Leveraging between HSC and UNM programs - i.e.Studies of cytokine-induced protein catabolism in vitro
     subsequently examined in patients with chronic kidney disease leading to studies examining the effectiveness of
     blocking cytokine activation in dialysis patients.

             • Partnerships
                     – Lovelace Respiratory Research Institute collaborative studies on vascular disease
                     – Sandia National Laboratory nanotechnology programs for detection of disease markers
                     – Numerous Pharma relationships for clinical trials and product testing and development




              HEALTH SCIENCES CENTER
                  Infectious Diseases and Immunity
Mission – To develop and enhance collaborative programs among researchers, physicians and businesses in New Mexico
to address the threat of infectious and immunologically mediated diseases in New Mexican populations and the world by
characterizing epidemiologic issues, studying basic host-pathogen mechanisms, developing new vaccines, therapeutics, and
diagnostics, and testing the preventive, therapeutic and diagnostic efficacy of these discoveries in clinical trials.

•Strategic organization to address national trends
      – CIDI nationally known for Biodefense
      – CIDI has outstanding emerging infections research: Hantavirus, tuberculosis, West Nile Virus

•Alignment with Training programs
      –Ninth year of T32 Infectious Disease and Inflammation training program
      –Funds grad students and postdocs
      –Center for Biomedical Research Excellence (COBRE) submitted 2007

•Integration of basic,clinical and translational Sciences
      –Vaccine preclinical development- Papilloma virus research
      –Tularemia vaccine development team
      –Translating genetically based predisposition to infections into drugs ( deCode project)

•Leveraging between HSC and UNM programs
      –Clinical and Translational Research Center
      –Center for Biomedical Engineering
      –Department of Computer Science
      –School of Pharmacy

                          •Partnerships - Lovelace Respiratory Research Institute, Sandia National Labs, Multiple
                          Biotechnology companies ( deCoded Genetics, Rules Based Medicine , Exagen Inc




                HEALTH SCIENCES CENTER
                                             Cancer
•   Mission
     –   The UNM Cancer Research & Treatment Center, is dedicated to curing cancer by conducting world class
         research, reducing cancer health care disparities in our NM population, educating the next generation of
         cancer researchers and healthcare professionals, and delivering state of the art cancer treatment to all New
         Mexicans.

•   Strategic organization to address national trends
     –   Achieve designation and federal funding from NCI as nations newest NCI designated cancer center
     –   One of Americas top 50 cancer hospitals (US News and World Report)

•   Alignment with training programs
     –   T35 for minority students

•   Integration of basic, clinical and translational Sciences
     –   Awarded NCI designation
     –   Nanoparticle imaging projects, genomic studies, clinical trials

•   Leveraging between HSC and UNM programs
     –   Integrates College of Pharmacy, multi-departments and School of Medicine

•   Partnerships
                  –   Lovelace Respiratory Research Institute
                  –   Sandia National Laboratories
                  –   Los Alamos National Labs
                  –   New Mexico’s Universities
                  –   New Mexico’s biotechnology industry
                  –   New Mexico Department of Health
                  –   Pueblo’s, Tribe’s and Indian Nations
                  –   Senior Scientific, Inc.



         HEALTH SCIENCES CENTER
         Environmental Health Sciences
•   Mission
     –   Studies potential environmental causes of airway inflammation, asthma, kidney disease, cancer
         and other environmental diseases

•   Strategic organization to address national trends
     –   Funded by NIEHS for $4.2M 4/03 – 3/07 (renewal planned 3/08)

•   Integration of basic, clinical and translational sciences
     –   Clinicians, applied and basic scientists as well as key community partners

•   Leveraging between HSC and UNM programs
     –   Strong collaborations between SOM and COP

•   Partnerships
     –   Lovelace Respiratory Research Institute
     –   UNM Advanced Research Cooperation in Health (ARCH) Grant between UNM (RIU) and University
         of Texas, El Paso (MSU)
     –   Border Health Collaborations
     –   Numerous native communities directly involved as collaborators in projects
     –   Sandia National Laboratories




         HEALTH SCIENCES CENTER
 NMCIM Progress on Research and Economic Development
    •   $1.03M Keck grant (Sklar, PI with UNM CRTC) enabled NMCIM to develop a
        unique and advanced small animal imaging resource (KUSAIR) in association
        with the UNM CRTC for micro-PET imaging and NanoSPECT/CT Imaging; an
        industrial partnership has been established with Bioscan, Inc

    •   The State of New Mexico Technology Research Consortium (TRC) committed
        $350K in funds to develop a Germanium-68 (Ge68) generator to produce Gallium-
        68 (Ga68) a 68 min half life PET imaging agent that can be linked to targeting
        molecules; we are in-line for more State and Federal funds

    •   Ga68 Generators will be developed in collaboration with industrial partners:
        production of Ga68 imaging agents will allow radiopharmaceuticals to be
        prepared independent of cyclotrons and will produce superior imaging quality
        with less radiation exposure

    •   First generation Ga68-DOTA imaging agents will be prepared to target
        somatostatin receptors and EGF receptors

    •   Future applications for estrogen receptors and LFA will utilize NanoSPECT/CT
A partnership between the University of New Mexico Health Sciences Center and Los Alamos National Laboratory
      General Clinical Research Center
                   (GCRC)
To provide state-of-the-art infrastructure support for NIH funded and
developing clinical and translational researchers, including space,
inpatient, outpatient and pediatric nursing, bionutrition, clinical
laboratory, biostatistics, biomedical informatics, and pharmacy
services.


       • Year 32 of funding with an annual budget from
         NCRR of approximately $3M
       • An essential resource for enabling physician-
         scientists to compete nationally
       • All 78 GCRC’s will be phased out by 2010 beginning
         this year




       HEALTH SCIENCES CENTER
                  Clinical and Translational Science Center
Enhanced Vision of healthcare and clinical research
                                      BEDSIDE                                                        •NIH initiative to transform the way in which clinical
                                                                                                     research and training is done
                                   Human Clinical
                                     Research
     T1                         Controlled Observational
                                                                                          T2/T3
                                                                           Practice-Based Research   •Designed to integrate clinical, translational and
Case Studies
Phase 1 and 2
                                         Studies
                                 Phase 3 Clinical Trials
                                                                                Phase 3 and 4
                                                                                 Clinical Trials
                                                                                                     basic science research
Clinical Trials                                                             Observational Studies
                                                                               Survey Research
                                                                                                     •Infrastructure to support integrated research
                                                                                                     structure

                                                                                                     •Educational component: New MSCR, PhD
                                                            Clinical Practice
          Basic Science
            Research
                                                                                                     programs
                                                       Delivery of Recommended Care;
                                                        Right Patient at the Right Time
          Preclinical Studies
                                                                                                     •Increase support to community and practice based
                                                         Identification of New Clinical
          Animal Research                                Questions and Gaps in Care

                                                                                                     research
   BENCH                                                                 PRACTICE
                                                                                                     •40-50 will be awarded by 2010 - assures that UNM
           Conceptual Process of Bench to                                                            will be in top 40-50 of HSCs in the country
            Bedside to Practice Research
                                                                                                     •$25 million over 5 years

                                                                                                     •Tobacco Settlement funds allocated for clinical
                                                                                                     trials within CTSC in FY08 and FY09


                                HEALTH SCIENCES CENTER
   New Model of Health Care Improvement:
     Linking Research and Clinical Care
• Identify community health priorities (liaisons, HEROs, Community
  Engagement Council, web page, database)

• Direct clinical trials and other interventions to community and local
  health care providers

• Find approaches that most effectively address health issues

• Establish education and dissemination processes that improve care
  in New Mexico communities




        HEALTH SCIENCES CENTER
              New Biotechnologies


• Biosensor



• One-handed Needle



• Screening Center



     HEALTH SCIENCES CENTER
        Molecular Libraries Network                                  HyperCyt Discovery Platform
                              U Pitts     U Penn




                                                      Columbia
                                                      Vanderbilt
    Burnham

    Scripps




                    UNM   Southern Research   Emory


     Discovery and Innovation                                      Biotech
                                                                   Economic Dev.


                                                                   Translation:
                                                                   Imaging
                                                                   Diagnostics
                                                                   Repurposing

                                              MLSCN Partnership Logos
The University of
New Mexico
Division of
BIOCOMPUTING
           Building a Biomedical Research Corridor in New Mexico



                           TruTouc h                                                                               Applie d
                                                                                Fe ldm a te c h, Inc .        Biophotonic s LLC



                                                                                                                       EndoSc re e n, LLC




Chris tm a s
                                                                                     He a lthConne c tPro
Cons ortium             Ca ps e da LLC




               Visualizing these partners within the Biomedical Research Corridor represents the meeting of
               our scientific expertise and intellectual property with commercialization of research results for the
               public good. Our faculty provide the intellectual property, expert consultation, and cutting edge
               business knowledge to make these startup companies and alliances a unique contribution to the
               State of New Mexico and the City of Albuquerque. Not only does the UNM Biomedical Research
               Corridor contribute to the public good by introducing exciting new products to the marketplace, it
               also makes a significant impact on the economic development of the state by providing jobs and
               HEALTH SCIENCES CENTER
               generating tax dollars. These partners and affiliates are examples of entrepreneurial efforts that
               exist, in part, due to the presence of the UNM Health Sciences Center.
                 Summary
• HSC has growing research enterprise that is
  disease-focused

• HSC seeks partners for commercialization and
  clinical application




    HEALTH SCIENCES CENTER

				
DOCUMENT INFO