Annual Reports CRIUGM 2000-2001 by yha69539

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									               Message from the Director of Research

The year 2000-2001 was a turning point for the       boursier junior2) has been recognized by the
planning and consolidation of research activi-       FRSQ for the excellence of his contribution in
ties in health and aging at the Institut universi-   functional neuroimaging as applied to aging,
taire de gériatrie de Montréal. The four-year        Furthermore, the FRSQ renewed the salary
Research Development Plan for 2001-2005 was          support for Drs. Martin Arguin (Department
submitted to the authorities at the Fonds de la      of Psychology, Faculty of Arts and Science;
recherche en santé du Québec in the fall of          chercheur-boursier junior1) and Hélène
2000. Following an evaluation project with a         Kergoat (School of Optometry; Chercheur-
visit from a committee of experts, the FRSQ          boursier clinicien junior2). These appoint-
Board of Directors approved the plan. It called      ments and reappointments were comple-
for pursuing the development of the themes           mented by the recruitment of many new
that are now the strongest, accompanied by a         researchers, who will allow for the consolida-
major consolidation of the weaker themes and         tion of certain of the Centre's themes. Thus,
the creation of a new research theme entitled        Dr. Martin Brochu (Department of Kinesiology)
Aging and society. The latter theme will enable      will initiate a research program on physical
us to intitiate the development of research          activity and energy expenditure as a promot-
activities of a social nature, by enabling us to     ing factor during aging. Dr. Jacqueline
bring together the creative forces in this field     Rousseau (School of Rehabilitation) also
at the Université de Montréal. This new four-        joined the Centre in order to pursue her work
year development plan will thus enable the           on the assessment of conditions for home
Research Centre to be better positioned at a         maintenance of elderly people. Finally, Dr.
critical time for research in health and aging in    Éric Fimbel (École de technologie supérieure)
our country. The plan will also allow, among         will pursue his research on the analysis of
others, for the introduction of critical masses      motor control during aging as well as in
of researchers covering all of the pillars of        Parkinson's disease. All told, the number of
health research; these include fundamental           researchers equivalent to full-time hours         Dr. Yves Joanette
research, clinical research, research on health      increased by close to 20% in 2000-2001, reach-    Director of Research
services and systems and the health of popula-       ing more than 26.5.                               accompanied by
tions, as well as research on the social and cul-                                                      Dr. André Davignon
tural aspects of health during aging.                In the same year, several researchers were        Special Scientific Adviser
                                                     recognized for the quality of their scientific
In 2000-2001 we saw a major shift as we              contribution. Thus two of the Centre's
increased the critical mass of researchers at        researchers, Drs. Franco Lepore and Maryse
our Institute. Several researchers were recog-       Lassonde, were chosen as recipients of a
nized by the Fonds de la recherche en santé du       Research Chair of Canada. Over 14 researchers
Québec (FRSQ) as researcher-grant recipients.        from the Centre collaborated with their peers
Dr. Francine Ducharme (Faculty of Nursing;           from the Lady Davis Institute within the
researcher-senior grant recipient) will thus be      framework of a major research program of
able to continue her excellente contribution         $1.6 million dealing with Cognition and
to research on nursing care for the elderly and      Aging. This project is coordinated by Drs. Yves
their families. Dr. Ducharme was appointed           Joanette and Howard Chertkow (Director of
holder of the Desjardins Chair in Nursing for        the Bloomfield Research Centre) and it should
the Elderly and their families; it enjoyed a         allow the researchers from the Centre to
financial infusion of one million dollars            further strengthen their positioning on the
from the Mouvement Desjardins. Dr. Bryna             national and international scene. As well, in
Shatenstein (Department of Nutrition, Faculty        collaboration with her colleagues from the
of Medicine) was named Chercheur-boursier            Groupe de recherche interdisciplinaire en santé
clinicien junior2 and will be able to continue       (GRIS) (Dr. François Béland), and from the
her major contribution to epidemiological            Lady Davis Institute and the McGill Chair in
research in nutrition and aging. Dr. Louise          Geriatrics, Dr. Paule Lebel received a major
Demers (School of Rehabilitation, Faculty of         grant from the Canadian Health Research
Medicine) was named Chercheur-boursier               Institutes. This interdisciplinary health
junior1. Her arrival represents an important         research group will be able to take on the
addition to the work of the Position, mobility       project: The challenge of understanding and
and aging theme. Dr. Demers, who was origi-          meeting the needs of the frail elderly in the
nally a clinician at the Institute and then          Canadian primary care system.
trained in research, offers unique expertise in
assessment of interventions intended for the         During this time, the Research Centre contin-
elderly. Dr. Mario Beauregard (Department of         ued to grow. The total amount of grants
Radiology, Radio-Oncology and Nuclear                and scholarships awarded to researchers at
Medicine, Faculty of Medicine; chercheur-            the Institute has reached approximately
                   Message from the Director of Research

    $4 355 000 for the year 2000-2001, translating
    into a triennial growth of about 30%. Support
    from the Foundation of the Institute enabled
    us to welcome four new post-doctoral fellows
    and made it possible to inaugurate a brand
    new evoked potentials laboratory which also
    received funding from the Canadian
    Foundation for Innovation.

    Finally, the Centre is continuing to make
    a major contribution to training the next
    generation of researchers, as we welcome an
    increasing number of researchers-in-training
    at the Master's and Ph.D. levels. Together, the
    researchers, their students and their partners
    have maintained a remarkable level of
    research productivity, publishing 17 books
    and 259 articles and book chapters. Research
    conducted at the Institute was reported at
    309 conferences in held in North and South
    America, as well as in Europe and the other

    The researchers and staff at the Research
    Centre have thus enabled the Institute to fully
    realize its research mission by strengthening its
    role as a leader in Québec and throughout the
    world in terms of research on health and aging.

Message from the Associate Director of Clinical Research

In terms of clinical research the year 2000-         In other news, a permanent place for the dis-
2001 was marked by significant development           semination of research results intended for
initiatives. First, in partnership with all of the   clinicians and other employees of the Institute
other centres of the Fonds de la recherche en        was inaugurated in the fall of 2000. A high-
santé du Québec (FRSQ), the Research Centre          traffic passageway in our building has been
of the Institute was invited to participate in       turned into "the Research Passage," which is
the development of a major grant submitted           now used for the permanent exhibition of
to the Canadian Foundation for Innovation.           posters presented by the Institute's researchers
The goal of this project is the development of       and clinician-researchers at local and interna-
infrastructures to promote clinical research in      tional scientific conferences. The posters are
Québec. Essentially, this request includes the       rotated on a regular basis and this passage
development of a research network intended           will ensure wide exposure for research with
to promote clinical research on the provincial       clinical applications.
level by giving researchers access to a central-
ized infrastructure that will facilitate the man-    Another initiative was to increase the links
agement of clinical studies. This project,           with the concerns and needs of the elderly
which has already received $2.5 million in           among us. In fact, the Research Centre has
funding from Valorisation-Recherche Québec,          appointed Dr. André Davignon as a special
is one of the priorities of the FRSQ which has       scientific consultant. Dr. Davignon, a retired
made the promotion of clinical research one          university professor and researchers, has been
of the pillars of its triennial plan.                mandated to establish a "Comité de sages"
                                                     (whose mission is to identify what it takes to
Several research teams from the Centre parti-        age well) in collaboration with the researchers
cipated in the development of an infrastruc-         and clinician-researchers at the Centre. He
ture project whose goal is the creation of a         will also help the Centre develop and consider
"Clinical research unit on cognition." This          research related to the theme of health and
grant request is part of an inter-institutional      society.
project led by Dr. Howard Chertkow at the
Lady Davis Institute; the project rests, to a        In closing, I would like to salute the leadership
large extent, on a structuring grant of $1.6         of several researchers and clinician-researchers
million from Valorisation-Recherche Québec           who, again this year, participated in the
dealing with cognition and aging (Drs. Yves          organization of many conferences and other
Joanette and Howard Chertkow, co-principal           continuing education activities largely focus-
investigators). The participation of the             ing on clinical aspects, thanks to the out-
Institute in this infrastructure project, coor-      standing work of Dr. Paule Level, Director of       Dr. Guylaine Ferland
dinated by Drs. Sylvie Belleville and Marie-         Teaching and Dissemination of Expertise, and        Director of Clinical
Jeanne Kergoat, would enable teams repre-            of Ms. Michèle Sirois, who is responsible for       Research
senting over 13 disciplines to join forces           the organization of scientific events. Thus, in
around a single infrastructure allowing for          November 2000, close to 400 participants
particularly inter-disciplinary research.            attended a conference entitled "Bien nourrir
                                                     les personnes âgées en institution: un défi à
The Advisory Board for Clinical Research             relever" and a second conference dealing with
(CAREC) continued to play the role of facilita-      "Médecins et pharmaciens: un tandem au ser-
tor among the Institute's researchers, clini-        vice des personnes âgées" was attended by over
cians and clinician-researchers. The CAREC           150 in March 2001.
was the driving force behind an event last
November that showcased and disseminated
the clinical research of the past year. This
initiative, entitled "La recherche clinique s'af-
fiche" took place over three days and allowed
over 100 people to contact one another. The
event was sponsored by the Canadian Dairy

                                                        Research Themes

                    Themes                             Research Topics                   Research Directors            Functional unit
                                            1.1 Language, communcation                                            U1 - Language
                                                                                       Dr. Gonia Jarema
                       1                        and aging                                                              and cognition
            Cognitive Neurosciences         1.2 Cognitive neuropsychology
                                                                                       Dr. Isabelle Peretz        U2 - Neuropsychology
                   and aging                    of aging
                                            1.3 Neurobiology and neuroimaging          Dr. Julien Doyon           U3 - Neurobiology
                                                                                                                       and neuroimaging
                                            2.1 Interventions and support
                        2                       programs and services
            Care and services for the           for family caregivers
            elderly and their families      2.2 Telemonitoring                         Dr. Francine Ducharme      U4 - Care and services
                                            2.3 Assessment of the quality
                                                of geriatric services
                                            2.4 Ethics
                                            3.1 Biology of nutrition and of aging
                        3                                                                                         U5 - Nutrition and
                                            3.2 Nutrition and the elderly person     Dr. Marie-Jeanne Kergoat
            Nutrition and the elderly                                                                                  clinical sciences
                                            3.3 Nutrition and the elderly population
                                            4.1 Engineering for rehabilitation
                                                applied to technical supports
                                                for posture and mobility
                        4                                                                                         U6 - Gesture,
                                            4.2 Use and satisfaction with
                 Positionning,                                                         Dr. Bernadette Ska              way-finding, and
                                                technical supports
               mobility and aging                                                                                      spatial orientation
                                            4.3 Movement and gesture
                                            4.4 Spatial orientation and finding
                                                finding one’s way
                       5                    5.1 Visual impairment
                                                                                       Dr. Sylvie Hébert          U7 - Sensory impairment
          Sensory impairment and aging      5.2 Hearing impairment

                                                            Researchers Council 2000 – 2001
                                         Researchers –                      Dr.   Sonia Lupien                 Dr. Maria Alice De Mattos
                                         Laboratory Directors               Dr.   Romedi Passini                   Pimenta Parente
                                         Dr. Martin Arguin                  Dr.   Isabelle Peretz              Dr. Zohra Mimouni
                                         Dr. Mario Beauregard               Dr.   Jacqueline Rousseau          Dr. Jacques Montplaisir
                                         Dr. Renée Béland                   Dr.   Jocelyne St-Arnaud           Dr. Laurent Mottron
                                         Dr. Sylvie Belleville              Dr.   Bryna Shatenstein            Dr. Hélène Pigot
                                         Dr. Martin Brochu                  Dr.   Bernadette Ska               Dr. Jean-Luc Nespoulous
                                         Dr. Howard Chertkow                Dr.   Lise Talbot                  Dr. Ugo Nocentini
                                         Dr. Louise Demers                  Dr.   Rhoda Weiss-Lambrou          Dr. Michel Panisset
                                         Dr. Julien Doyon                   Dr.   Christina Wolfson            Dr. Carole Paradis
                                         Dr. Laurette Dubé                                                     Dr. Jacinthe Pepin
                                         Dr. Francine Ducharme              Associate Researchers              Dr. Agnessa Pillon
                                         Dr. Guylaine Ferland               Dr. Paulo Caramelli                Dr. Gilles Plourdes
                                         Dr. Eric Fimbel                    Dr. Julie Carrier                  Dr. Lucie Richard
                                         Dr. Michel Habib                   Dr. Nathalie Champoux              Dr. Luc Rousseau
                                         Dr. Sylvie Hébert                  Dr. Jacques Bruno Debruille        Dr. Xavier Seron
Researchers present at the               Dr. Gonia Jarema                   Dr. Pierrette Gaudreau             Dr. Brigitte Stemmer
Annuel Photo Session                     Dr. Yves Joanette                  Dr. Serge Gauthier                 Dr. Josée Verdon
                                         Dr. Hélène Kergoat                 Dr. Prathibha Karanth
                                         Dr. Marie-Jeanne Kergoat           Dr. Raymonde Labrecque             Guests
                                         Dr. Maryse Lassonde                Dr. Guylaine LeDorze               Ms Johanne Dupuis
                                         Dr. Paule Lebel                    Dr. Gary Libben                    Ms Christine Kaegi
                                         Dr. André Roch Lecours             Dr. Isabelle Lussier               Ms Nathalie Walter
                                         Dr. Franco Lepore                  Dr. David McFarland                Dr. Sophie Blanchet
                                         Dr. Tony Leroux                    Dr. Hélène Masson
                                         Ms Louise Lévesque                 Dr. Fadi Massoud
                               Research Committee

Research Committee:                               Executive Committee:
Yves Joanette, Research Director and              Yves Joanette, Research Director and
Chairman of the Research Committee                Chairman of the Executive Committee
Christiane Lepage, Interim Chairman,              Céline Crowe, Representative of the
Council of Physicians, Dentists and               General Administration
Pharmacists                                       Johanne Dupuis, Administrative Director
Céline Crowe, Director of Professional            and Recording Secretary for the Executive
and Hospital Services                             Committee
Guylaine Ferland, Associate Director of           Guylaine Ferland, Associtate Director
Clinical Research                                 of Clinical Research
Paule Lebel, Director of Teaching                 Paule Lebel, Director of Teaching
Johanne Théoret, Director of Nursing Care         Unit Directors:
Colette Tracyk, Executive Director                Francine Ducharme, Care and Services
Representative(s) elected                         Julien Doyon, Neuroimaging and
by the Researchers Council:                       Neurobiology
Francine Ducharme, Faculty of Nursing             Sylvie Hébert, Sensory Impairment
Marie-Jeanne Kergoat, Faculty of Medicine         Gonia Jarema, Language and Cognition
Romedi Passini, Faculty of Architecture           Marie-Jeanne Kergoat, Nutrition and
Sylvie Belleville, Faculty of Arts and Sciences   Clinical Science
Nathalie Walter, Graduate student                 Isabelle Peretz, Neuropsychology
representative                                    Bernadette Ska, Mobility/Way-finding

Advisory Board for Clinical Research(CAREC):      Scientific Evaluation Committee:
Guylaine Ferland, Associate Director of           Bryna Shatenstein, Chairman
Clinical Services and Chairman of the CAREC       Renée Béland, Researcher
Céline Crowe, Director of Professional            Hélène Kergoat, Researcher
and Hospital Services                             Paule Lebel, Researcher
Johanne Dupuis, Administrative Director           Bernadette Ska, Researcher
and Recording Secretary for the CAREC             Rhoda Weiss-Lambrou, Researcher
Representative(s) of the clinical sectors:
Sophie Barsetti, Nursing Care                     Research Ethics Committee:
Martine Gaudreault, Clinical Nutrition            Louise Francoeur, Specialized nurse clinician
Brigitte Gilbert, Neuropsychology                 and Chairman of the Ethics Committee
Suzanne Généreux, Speech Therapy                  Mario Beauregard, Researcher
Suzanne Gilbert, Pharmacy                         Céline Crowe, Director of Professional
Cristine Kaegi, Physiotherapy                     and Hospital Services
Hélène Kergoat, Optometry                         Brigitte Damien, Speech therapist
Marie-Jeanne Kergoat, General Medicine            Johane de Champlain, Lawyer
Elaine Laberge, Social Services                   Eric Fimbel, Researcher
Christiane Lepage, General Medicine               Johanne Lévesque, Research Centre
Hélène Matteau, Occupational Therapy,             student representative
Day Hospital                                      Fadi Massoud, Geriatrist
Researcher’s Representatives:                     Monique Normandin, Representatative
Francine Ducharme, Researcher                     of the general public
Bernadette Ska, Researcher                        Vincent Paquette, Research Centre
                                                  student representative
Nominating Committee                              Marie-Hélène Parizeau, Ethicist
Yves Joanette, Chairman of the
Nominating Committee                              Scholarships Committee
Sylvie Belleville, Researcher                     Francine Ducharme, Chairman
Francine Ducharme, Researcher                     of the Scholarships Committee
                                                  Sylvie Hébert, Researcher
                                                  Bryna Shatenstein, Researcher

                                            Theme 1.1 Neurosciences and Aging
                                                                  Language, Communication and Aging Unit

                          The Language and cognition unit in the               M. Habib and B. Ska) and had received a
                          Cognitive Neurosciences and aging theme              Québec-Italy scientific cooperation grant with
                          includes researchers from the Faculty of             the group from the San Rafaelle Hospital in
                          Medicine and the Faculty of Arts and Science.        Milan (Drs.Y. Joanette and M. Beauregard at
                          Its interdisciplinary research programming           the Institut de gériatrie de Montréal and Drs.
                          deals with the nature and treatment of lan-          S. Cappa and D. Perani in Milan; A. I. Ansaldo,
                          guage impairment that often accompanies               .
                                                                               P Vityali and N. Walter, student collaborators).
                          cerebrovascular accidents or certain neu-            Moreover, Dr. Joanette has pursued research
                          rodegenerative diseases.                             on the transfer of knowledge to users (speech
                                                                               therapists) through the development of the
                          The international team led by Dr. Gonia              first protocol actually intended for the assess-
                          Jarema continued its research on the mental          ment of communication impairment in
                          lexicon as part of a vast research project fund-     patients with right-sided brain lesions. The
                          ed by a grant from the Social Sciences and           protocol was developed and validated in the
                          Humanities Research Council of Canada                clinical settings directly involved in this
                          (SSHRC) within its Major Research Initiatives        project (Institut universitaire de gériatrie de
                          program. This research follows an interdisci-        Montréal, Hôpital Marie-Clarac, Villa Medica,
                          plinary and cross-linguistic approach; its           Jewish Rehabilitation Hospital, Centre de
                          objective is to study the cognitive processes of     réadaptation Lucie-Bruneau, and the Montreal
                          the access, representation and organization of       Rehabilitation Institute). It was then standard-
                          words in people with language impairment as          ized by student researchers during the sum-
                          well as in normal elderly people. Dr. Jarema's       mer of 2001. Finally, the team welcomed an
                          team is composed of many Canadian and                American student in the winter of 2001 (W.
                          foreign researchers, post-doctoral fellows,          Fassbinder, University of Pittsburgh).
                          and students at the Master's and Doctoral
                          levels enrolled in biomedical science, linguis-      Dr. Michel Habib has pursued his research on
                          tics, and neuropsychology. In the fall of 2000,      the neurobiological bases of oral and written
                          Dr. Jarema organized the Second International        language impairment. Among his many
                          Conference on the Mental Lexicon, which was          research projects, he focused on the issue of
                          attended by close to 150 people from all over        language impairment in primary progressive
                          the world. This meeting enabled researchers          aphasia. One study even dealt with the assess-
Dr. André Roch Lecours,   to establish new international research part-        ment of possible pharmacological adjuvants
Dr. Gonia Jarema          nerships, to bring new renowned foreign              in speech therapy for these individuals.
                          collaborators onto the team, and to publish a        Dr. Habib also pursued his study of the issue
Dr. Yves Joanette
                          triple Special Issue of the international journal    of written language impairment from a devel-
                          Brain and Language (forthcoming in 2002).            opmental perspective.
                          The research conducted by Dr. Jarema's team
                          also contributed to the preparation of a             Dr. André Roch Lecours continued his research
                          Special Issue of Folia Linguistica (Guest edi-       on speech and language disturbances, reading
                          tors, Dr. G. Libben and Dr. G. Jarema; publica-      aloud and writing to dictation. This research
                          tion in 2002). In addition, Dr. Jarema's team        focuses on diseases affecting the brain that
                          has initiated research within a Valorisation         have sudden onset, as well as degenerative
                          Recherche Québec project (led by Dr. A.M.            types. The research now in progress deals with
                          Di Sciullo, Université du Québec à Montréal                                                 .
                                                                               deep dyslexia (collaboration with Dr. P Karanth,
                          (UQAM) integrating, UQAM, Université de              India) and pure anarthria (collaboration with
                          Montréal, McGill University and Université           Dr. M. A. De Mattos Pimenta Parente, Brazil).
                          Laval. Finally, in the fall of 2000, the team wel-   Other topics have also been investigated,
                          comed a post-doctoral fellow (Dr. S. Mondini,        including written language impairment and
                          University di Padova, Italy) under the auspices      the mental lexicon in Alzheimer's disease,
                          of the Québec Bourses d'excellence program.          and the role of the right hemisphere in
                                                                               recovery from aphasia among right-handed
                          Dr. Yves Joanette's interdisciplinary team con-      patients.
                          tinued its research on the contribution of the
                          right hemisphere (RH) to verbal communica-           In October 2000, Dr. Joanette and Dr. Jarema
                          tion and on the impacts of right lesions in          organized the annual meeting of the Academy
                          right-handed people. This research, funded           of Aphasia in Montreal. This is the largest
                          by the Canadian Institutes for Health Research       conference in the world in the field of aphasi-
                          (Dr. B. Ska, co-principal investigator) dealt        ology. Finally, Dr. Joanette and Dr. Jarema
                          with a set of communication impairments              are continuing to contribute to the world of
Researchers theme 1.1     commonly occurring in individuals with               scientific publication, working respectively as
                          right-hemisphere lesions.                            Associate Editor and member of the Editorial
Dr. Michel Habib
                                                                               Board for the journal Brain and Language.
Dr. Gonia Jarema          Dr. Joanette also initiated research dealing         Dr. Habib continues to act as Co-Editor-in-
Dr. Yves Joanette         with the nature of inter-hemisphere coopera-         Chief of the Revue de neuropsychlogie de
Dr. André Roch Lecours    tion underlying recovery from aphasia. This          langue française.
                          research is now funded by the Canadian Heart
                          and Stroke Foundation (Drs. Y. Joanette,
                  Theme 1.2 Neurosciences and Aging
                                        Cognitive Neuropsychology and Aging Unit

The Cognitive neuropsychology and aging Unit        • Dr. Martin Arguin and his team have made
in the Neurosciences and aging theme contin-          inroads in the fields of acquired dyslexia
ued its research on the comprehension of              following a cerebral accident (in elderly
the mechanisms underlying cognitive impair-           adults). They observe that letter-by-letter
ments related to aging and those that charac-         dyslexia, which is characterized by a severe
terize neurodegenerative diseases (such as            difficulty in recognition of written words
Alzheimer's) that have an impact on memory            and appears to occur via a sequential
and other components of cognition. This               processing of the letters, actually deals
interdisciplinary team brings together the            with the interface between the visual and
creative forces of the Université de Montréal         orthographic processes (with these two
in its field. The team is interested in develop-      systems actually being intact).
ing diagnostic and intervention tools in clini-
cal neuropsychology and in related fields           • Dr. Sylvie Belleville and her team probed
(such as the neurology of behaviour and geri-         memory systems among normal elderly
atrics). It also focuses on the mild cognitive        patients with slight cognitive difficulties and
disorders that characterize a sub-set of elderly      with dementia of the Alzheimer type, in
individuals prone to develop Alzheimer's              order to identify tests likely to be specific
disease or an associated dementia.                    to dementia of the Alzheimer type and test
                                                      that are sensitive as early as the first pre-
During the year 2000-2001, the cognitive neu-         clinical signs (i.e. among patients with slight
ropsychology team opened two new laborato-            cognitive impairment). To accomplish this,
ries, one specializing in the eletrophysiologi-       Dr. Belleville is an active participant in a
cal measurements known as evoked brain                large multi-centre study involving the
potentials. This unit includes three separate         majority of memory clinics in Québec; the
recording rooms with 64-channel devices.              goal of this process is to create a registry and
The other laboratory is intended for innova-          thus to accumulate clinical, neuropsycho-
tive research using the transcranial magnetic         logical and neurodiological data among
stimulation technique. Beyond its desire to           patients with slight cognitive impairment,
develop tools that explore the higher cognitive       or among those suffering from Lewy body
functions, the team is continuing its cognitive       dementia or fronto-temporal dementia.
neuropsychology research on bilingualism,
reading systems, memory systems, emotions           To summarize, the research conducted by the
and the possible link between cerebral con-         Cognitive Neuropsychology and Aging Unit in
cussion and dementia. The researchers' work         the Neurosciences and aging theme is
can be best illustrated with the following          enabling us to forge ahead with knowledge
examples:                                           about cognitive impairment in the elderly.
                                                    Doing so will enable us to foresee practical
• Dr. Renée Beland and her team conducted           applications intended to maintain the quality        Dr. Renée Béland
  an in-depth study of a bilingual (Arabic-         of life of the elderly.                              Dr. Sylvie Belleville
  French) aphasic patient and showed that a                                                              Dr. Martin Arguin
  left brain lesion affects both of the patient's
  languages. The analysis, based on a connec-
  tionist model, allows for detection of cross-
  linguistic errors, i.e. those errors involving
  the interrelations—such as translation
  errors—between the two languages.

                                                                                                         Researchers theme 1.2
                                                                                                         Dr. Martin Arguin
                                                                                                         Dr. Renée Béland
                                                                                                         Dr. Sylvie Belleville
                                                                                                         Dr. Maryse Lassonde
                                                                                                         Dr. Isabelle Peretz

                                   Theme 1.3 Cognitive Neurosciences and Aging
                                                         Neurobiology and Neuroimaging Unit

                           The year 2000-2001 will have been a remarkable      bellum in motor type of learning. Together
                           year for the researchers in the Neurobiology        with researchers from both Harvard University
                           and Neuroimaging Unit in the Cognitive              and McGill University, he published a 3-D
                           Neurosciences and Aging theme. As witnessed         stereotaxic atlas of the human cerebellum that
                           by their scientific productivity and their envi-    will serve members of the scientific communi-
                           able position on the strategic and political lev-   ty who are interested in the precise study of
                           els, they were able to consolidate their role on    the functional cartography of the cerebellum
                           the national and international scene. During        in PET and fMRI studies. In collaboration with
                           the past year, the researchers in this unit have    colleagues at the Institut de réadaptation en
                           maintained and even increased the number            déficience physique du Québec, he also com-
                           of publications that have appeared in presti-       pleted a series of experiments on the neurobi-
                           gious scientific journals as well as the dollars    ological bases of motor learning.
                           brought in through research grants from
                           provincial, federal and American funding            The researchers in the Neurobiology and
                           sources. In addition, under the scientific          Neuroimaging Unit have played a leading role
                           direction of Dr. Julien Doyon, the researchers      with regard to the efforts made for the imple-
                           have either sponsored or participated in the        mentation of infrastructures for research in
                           design and writing of grant requests totalling      the neurosciences of aging. Thus, Dr.
                           close to $19 million, which will serve to create    Chertkow directed the Québec Consortium for
                           the material and intellectual infrastructure        Alzheimer's disease, which submitted a
                           likely to benefit the entire scientific commu-      request to the program for the Canadian
                           nity in neurosciences at the Université de          Foundation for Innovation (CFI) for a single
                           Montréal and elsewhere in Québec.                   infrastructure targeting neurodegenerative
                                                                               pathologies. In his capacity as Assistant to
                           As far as scientific production, the researchers    the Director for Neuroimaging, Dr. Doyon
Dr. Mario Beauregard       in this unit have pursued their respective          participated in the preparation and writing
Dr. Julien Doyon           research programs, thus significantly con-          of a grant for $16.6 million to the CFI for the
                           tributing to the advancement of knowledge           acquisition of a high-power (3.0T) magnetic
                           in the field of normal and pathological aging       resonance imager and several optical imaging
                           as well as to other related fields of research.     and high-density evoked potential units.
                           Dr. Mario Beauregard, who holds a research          Dr. Doyon also directed a request to the
                           grant from the Fonds de la recherche en santé       Regroupement provincial pour la recherche
                           du Québec (FRSQ), continued his research            en imagerie cérébral (REPRIC) or Provincial
                           using functional magnetic resonance imaging         Group for Brain Imaging Research to the
                           (fMRI) to identify cerebral systems associated      Network of neurosciences and mental health
                           with primary emotions as well as the con-           in Québec for the introduction of an infra-
                           scious and voluntary self-regulation of emo-        structure able to facilitate the development
                           tions. Dr. Howard Chertkow continued his            of multicentre and multidisciplinary research
                           work aiming to identify the biological deter-       in brain imaging in Québec.
                           minants of dementia and slight cognitive
                           impairment. In collaboration with Dr. Yves
                           Joanette, he obtained a major Valorisation
                           Recherche Québec (VRQ) grant that allows for
                           a solid alliance between researchers at the
                           Lady Davis Institute and those at the Research
                           Centre. Dr. Doyon and his colleagues pub-
                           lished results of studies aiming to identify the
                           distinct contribution of the striatum and cere-

   Researchers theme 1.3
   Dr. Mario Beauregard
   Dr. Howard Chertkow
   Dr. Julien Doyon

Theme 2 Care and Services for the Elderly and their Families

During the year 2000-2001, the theme Care           a dissemination plan so that the intervention
and services for the elderly and their families     program is implemented in the CLSCs and
consolidated and expanded its activities. The       Alzheimer's Society of Québec.
research conducted is characterized by its
interdisciplinary and intersectoral approach        Among the research currently in progress,
and the partnerships it favours with                Dr. Kergoat and the members of her team are
researchers from different universities and         working on the quality of the care and services
faculties, as well as with many community-          for the frail elderly through the use of the
based and health network organizations.             "fall" as tracer cases and Mrs. Lévesque is
                                                    completing an epidemiological study on the
Thus, many researchers have joined new              needs that have not been met for community
interdisciplinary teams. Drs. Paule Lebel,          services among those aged 75 and older.
Francine Ducharme, Marie-Jeanne Kergoat             Drs. Lebel and Ducharme recently obtained
and Louise Lévesque are members of a team           a grant that will enable them to carry out an
that received a major grant from the Canadian       evaluative study of stress management inter-
Institutes for Health Research whose program        vention for family caregivers living with a frail
is entitled "Understanding and meeting the          elderly person at home.
needs of the frail elderly in the Canadian
health system." Dr. Lebel is in charge of the       The activities planned in the program for the
section of the program dealing with the devel-      Research Chair in Nursing Care for the Elderly
opment and assessment of innovative models          and their Families are also being pursued.
of intervention and services for the elderly.       During the year, this Chair received a major
Dr. Ducharme and Mrs. Lévesque are co-              donation from the Desjardins movement. The
investigators on a team that has received           holder of the Chair, Dr. Ducharme, and her
a grant from the Canadian Foundation for            team are carrying out two studies with fund-
Research on Health Services whose work deals        ing from the grant: one deals with the orienta-
with optimizing quality of care in home care        tion of care and services to be offered to fam-
services and Dr. Ducharme is one of the lead        ily caregivers of the elderly in light of the
researchers in a team grant from the Fonds          "virage ambulatoire" or shift towards ambula-
pour la Formation de Chercheurs et l’Aide à         tory care, and the second deals with the multi-
la Recherche (FCAR) charged with developing         centre assessment of a program promoting
family nursing interventions in the context         mental health of caregivers of elderly relatives
of the shift towards ambulatory care (virage        living in nursing homes. Students from Spain,
ambulatoire). Moreover, the McGill/Université       Brazil, and Lebanon have joined the research
de Montréal research group on integrated            activities of this Chair. As well, from an inter-
services for the elderly, with Dr. Lebel as a co-   national perspective, a project is under way
principal investigator, has completed the eval-     on the health of caregivers in Lebanon, under-
uation of the experimental SIPA (Système de         taken with a grant from the World Health
soins intégrés pour les personnes âgées en perte    Organization and the Université St-Joseph de
d'autonomie) model. The results are proving         Beyrouth. Mrs. Lévesque and Dr. Ducharme            Dr. Francine Ducharme
to be promising for the organization of care        are co-principal investigators in this study.       Dr. Jocelyne St-Arnaud
and the follow-up is now being considered with
the politicians and those in practical settings.    Finally, the year was particularly significant
                                                    for Mrs. Lévesque who was recognized for
Researchers have also taken an active role          her outstanding contribution to research on
in the activities of the Geronto-Geriatric          the care of the elderly: she received both a
Research Network which receives funding             Merit Award (the Insigne du mérite) from the
from the Fonds de la recherche en santé du          Québec Order of Nurses, and the Armand
Québec (FRSQ). Dr. Kergoat has been appoint-        Marquiset des Petits frères des pauvres Prize.
ed Assistant Director of the Network, while         Dr. Ducharme was appointed Associate Editor
Dr. Lebel and Mrs. Lévesque are responsible         of a new international periodical, Dementia,
for the themes dealing respectively with the        The International Journal of Social Research
organization and assessment of health servic-       and Practice. With the recruitment of
es and on family caregivers and professionals.      Dr. Jocelyne St-Arnaud, an ethicist, the com-       Researchers theme 2
Within the framework of activities on family        ing year will lead to the opening of a new field    Dr. Francine Ducharme
caregivers and professionals, an evaluative         of research dealing with decision-making of         Dr. Marie-Jeanne Kergoat
study on an group intervention intended for         family members concerning treatments and            Dr. Paule Lebel
caregivers of elderly parents suffering             the last days of their elderly parents' lives.      Mrs. Louise Lévesque
from dementia came to a close this year.                                                                Dr. Jocelyne St-Arnaud
Mrs. Lévesque and Dr. Ducharme were
members of this team, which is developing
                                                  Theme 3 Nutrition and the Elderly

                              The researchers in this unit, which corresponds      The researchers in the Nutrition and the elder-
                              to the Nutrition and the Elderly theme, come         ly theme continued working in collaboration
                              from several departments in the Faculty of           with the Réseau de recherche québécois en
                              Medicine as well as from the Department of           gérontologie-gériatrie and coordinated one of
                              Kinesiology. In 2000-2001 they continued their       two experimental sites for a pilot study under-
                              research programming, focusing on several            taken to assess the feasibility and to test the
                              essential aspects, aiming to analyze the condi-      tools proposed as part of a submission to the
                              tions that would allow for treatment and pre-        Canadian Health Research Institutes dealing
                              vention of nutritional problems in the elderly       with a longitudinal study focusing on nutri-
                              person. This unit is characterized by the broad      tion considered as a determinant in successful
                              spectrum of its methodologies and approaches,        aging. As part of these preparatory studies,
                              simultaneously embracing basic animal                Dr. Bryna Shatenstein (Fonds de la recherche
                              research, clinical and epidemiological research.     en santé du Québec (FRSQ) chercheure bour-
                                                                                   sière-clinicienne) evaluated the measurement
                              Thus, a colossal amount of information has           qualities of a diet frequency questionnaire
                              been collected in the geriatric rehabilitation       that she developed based on data from the
                              program in 2000-20001 as part of a project           Santé-Québec survey. This tool should allow
                              aiming to identify the determinants of dietary       for assessing the quality of dietary intake
                              intake in geriatric care hospitals. In order to      among the elderly.
                              carry out this study, a tool to assess the senso-
                              rial quality of the foods first had to be con-       Dre Kergoat’s team carried out secondary
                              structed and then validated. Simultaneously,         analyses of the Canadian Study of Health and
                              and as part of the same study, a structured          Aging which allowed researchers to establish
                              plan of the various steps in the process of          the prevalence (ESVC-1, 1991-92) and the
                              meal selection, preparation, and distribution        incidence (ESVC-2, 1996) of dementia in the
                              had to be developed in order to be able to           Canadian population. We analyzed the changes
                              analyze the organizational factors involved in       in weight and certain anthropometric variables
                              the nutritional care of this clientele. Particular   in the course of aging in relation to cognitive
                              focus was placed on the role of the emotional        status. This work led to the publication of three
                              and interpersonal aspects in the level of satis-     articles and scientific presentations.
Dr. Marie-Jeanne Kergoat,     faction among patients and care providers
Dr. Guylaine Ferland,         concerning the food and impact on the nutri-         The research project on the role of vitamin K
Dr. Bryna Shatenstein         tional state.                                        in the control of anticoagulation treatment
Dr. Martin Brochu                                                                  using Warfarin has been completed and the
                              Within the framework of the Program for              findings are now being analyzed. This project
                              Integrated Care of the Frail Elderly (known by       will have allowed for enhancement of clinical
                              the French acronym SIPA) that is operating in        practice by providing nutrition professionals
                              two CLSC territories in the Montreal-Centre          with a detailed listing of the vitamin K content
                              Regional Board, and on which researchers in          of certain foods. Dr. Guylaine Ferland acted as
                              our Centre are collaborating, the researchers        the Canadian expert on vitamin K on the micro-
                              in this unit are interested in the application of    nutriments committee (Canada-US harmoniza-
                              a screening protocol for nutritional problems        tion) involved in developing official standard
                              and have started the assessment.                     recommended dietary requirements (RDR).

                              The researchers in this unit have published          Basic research dealing with the role of vitamin K
                              two articles in the year 2000 describing the         in breast neoplasia is continuing and a new
                              success of the project to decentralize the           study is beginning on the role of this vitamin
                              portioning of meals in nursing homes for             in the synthesis of brain lipids and cognitive
                              the elderly. The members of this theme and           functions.
                              two students enrolled in graduate studies
                              related to this theme actively collaborated          Research is also continuing on the role of
                              on the Symposium Nutrition and the Elderly:          calorie intake on endocrine functions of the
   Researchers theme 3        "Providing nutritional food for elderly patients     somatotrophic axe.
   Dr. Martin Brochu          in institutional settings: A challenge to be met"
   Dr. Laurette Dubé          organized in November 2000 by the Teaching           In conclusion, this year has been very produc-
   Dr. Guylaine Ferland       Department of the Institute. This sympo-             tive and augurs well for continuing at the
   Dr. Marie-Jeanne Kergoat   sium, with over 400 participants, was a huge         same pace in the year 2002.
   Dr. Bryna Shatenstein      success.
   Dr. Christina Wolfson

                Theme 4 Position, Mobility and Aging

The unit of researchers responsible for the       is Dr. Louise Demers, also a professor at the
Position, Mobility and Aging theme continued      École de réadaptation and a junior Fonds de
to pursue its research programming dealing        la recherche en santé du Québec (FRSQ)
with a better understanding of disturbances of    researcher-grant recipient. She is focusing
mobility and movement of the elderly and the      on the development of tools to assess the
tools required.                                   effectiveness of rehabilitation interventions
                                                  for the elderly, while pursuing her work on
The year 2000-2001 was fruitful both in terms     satisfaction with technical aids.
of the quality of the research conducted and
in terms of the increase in human and materi-     It goes without saying that there are numer-
al resources in the unit. In fact, Dr. Romedi     ous real and potential interactions between
Passini's team continued its research on spa-     researchers in this theme. Some examples of
tial orientation in a natural setting and in a    these interactions follow. Dr. Fimbel designed
human-sized labyrinth. A post-doctoral fellow,    a computer program to analyze routes repro-
Dr. Isabelle Écuyer-Dab, joined the team          duced from memory by subjects who navigated
thanks to a Governor's grant from the             Dr. Passini's labyrinth. Dr. Demers collaborat-
Foundation of the Institut universitaire de       ed, with Dr . Passini, on a study on spatial ori-
gériatrie de Montréal. Dr. Bernadette Ska         entation among elderly people in nursing care
obtained a grant for a sabbatical in France,      facilities. Drs. Rousseau and Demers have
where she is pursuing research on the cogni-      projects whose goal is to improve rehabilita-
tive aspects of normal and pathological aging.    tion services for the elderly. Dr. Rousseau
Dr. Rachid Aissaoui took on a professorship at    will continue her research with Dr. Rachid
the École de technologie supérieure (Université   Aissaoui on wheel-chair ramp accessibility.
du Québec à Montréal) and he is continuing        Drs. Bernadette Ska and Jacqueline Rousseau
his research on the positioning of the elderly.   are collaborating on the development of a
                                                  needs assessment tool for elderly people with       Dr. Louise Demers
What made this year special for this unit was     cognitive disturbances who are living at home.      Dr. Bernadette Ska
the recruitment of three new researchers.         Drs. Ska and Demers have been working               Dr. Jacqueline Rousseau
The first is Dr. Eric Fimbel, Professor at the    together since Dr. Demers was a graduate
École de technologie supérieure. Dr. Fimbel       student under Dr. Ska.
has undertaken research on the analysis and
modelling of rapid movements. He is develop-      There are numerous interactions among
ing projects in neuroergonomics and is inter-     the researchers in the Positioning, mobility
ested in movement problems that arise in          and aging theme and they are strictly oriented
degenerative illnesses. The second recruit is     towards adaptation and rehabilitation of the
Dr. Jacqueline Rousseau, a professor at           elderly. The researchers in this theme also col-
the École de réadaptation of the Faculty of       laborate in the programming of other research
Medicine. She has developed a model of            themes in the Centre, in a spirit of inter-theme
analysis of the person-environment relation-      collaboration—on themes as diversified as
ship within the framework of maintaining          cognition, communication, nutrition, geri-
the elderly at home. In the first phase, her      atrics, and nursing. Taken as a whole, this
research has focused on elderly people with       body of research is truly multidisciplinary
motor impairments. She will pursue her            and trans-sectoral.
research, expanding the application of the
model and of the resulting analysis tool to
people with cognitive impairment and those
with sensory impairment. The third recruit

                                                                                                      Researchers theme 4
                                                                                                      Dr. Louise Demers
                                                                                                      Dr. Eric Fimbel
                                                                                                      Dr. Romedi Passini
                                                                                                      Dr. Jacqueline Rousseau
                                                                                                      Dr. Bernadette Ska

                                          Theme 5 Sensory Impairment and Aging

                            Introduced in 1998, the unit of researchers         In terms of hearing, the goal of the research
                            corresponding to the Sensory impairment             program is a better understanding of the
                            and aging theme includes researchers from           mechanisms underlying hearing impairment,
                            the School of Optometry, Dr. Hélène Kergoat,        which is the third most frequent chronic dis-
                            the School of Speech Therapy and Audiology,         ability among the elderly, after arthritis and
                            Drs. Sylvie Hébert (Fonds de la recherche en        hypertension. The research team is continuing
                            santé du Québec chercheure-boursière) and           its studies of the treatment of the temporal
                            Tony Leroux, the Department of Psychology,          dimension of acoustic stimuli. This temporal
                            Dr. Franco Lepore, and from the Department          treatment is at the basis of several auditory
                            of Medicine/Geriatrics, Dr. Marie-Jeanne            skills including the detection of rapid acoustic
                            Kergoat. The team constitutes a unique group        changes in speech. The research focusing on
                            of researchers from a variety of disciplines        tinnitus (buzzing) has shown a link between
                            working in the science of vision and hearing        the stress linked to tinnitus and the presence
                            in the elderly.                                     of depression. Thus, the validation of a ques-
                                                                                tionnaire assessing the psychological impact
                            In terms of visual impairment, the research         of tinnitus in those with this disorder is in
                            team is pursuing its work aiming to evaluate        progress. This clinical tool will prove extremely
                            visual functions in dementia of the Alzheimer       valuable here for health professionals who
                            type (DAT). The research has enabled us to          will be able to identify people who need short-
                            identify the presence of deficits in the primary    term attention. Another study is also under
                            visual paths of healthy elderly subjects and        way to evaluate the possible links between the
                            individuals with dementia of the Alzheimer          presence of tinnitus and that of excessive sen-
                            type. In addition, they have shown that indi-       sitivity to surrounding noises and sounds
                            viduals with DAT presented a delay in the           called hyperacousia.
                            transmission of retino-cortical nerve informa-
                            tion. During the year 2000-2001, a follow-up        The researchers in this unit receive funding
                            study allowed for verifying that the delay in       from public granting bodies, including the
                            nerve transmission identified in DAT was still      Canadian Health Research Institutes and the
                            present, but had not progressed some 18             Fonds pour la recherche en santé du Québec
Dr. Sylvie Hébert,          months after the initial visit of the subjects      (FRSQ). Our researchers have also been invited
Dr. Franco Lepore           evaluated. The goal now is to better define         to present their work at several conferences
Dr. Hélène Kergoat          the degenerative changes to the visual path-        including the International Association of
                            ways of DAT subjects and to compare them            Logopedics and Phoniatrics which was held
                            with other pathologies in order to find mark-       in Montreal in the summer of 2001.
                            ers for Alzheimer's type disease before its clin-
                            ical appearance. The research program also
                            deals with macular degeneration linked to age
                            (ALMD): which is the greatest cause of blind-
                            ness among those aged 65 and over in North
                            America. One of the hypotheses entertained
                            involves a better understanding of the role
                            played by the choroid in ALMD. Thus, the
                            blood flow to the choroid will be assessed in
                            two groups of elderly subjects with different
                            types of ALMD and one group of control sub-
                            jects. If the results of this study show a link
                            between ALMD and choroid blood flow, then
                            it may become an important clinical tool in
                            the follow up of patients with this disease and
                            in the various treatments used for it.

 Researchers theme 5
 Dr. Sylvie Hébert
 Dr. Hélène Kergoat
 Dr. Marie-Jeanne Kergoat
 Dr. Franco Lepore
 Dr. Tony Leroux

                                             Researcher Training

Increasing the research capacity                                            from the diversity of the students' academic
in health and aging                                                         origins : out of the 156 students and post-doc-
                                                                            toral fellows, 42% are registered in the Faculty
In 2000-2001, the Research Centre of the                                    of Medicine, 37%, in the Faculty of Arts and
Institute pursued one of its major objectives                               Science and 14% in the Faculty of Nursing.
which is to increase the research capacity in                               The number of students and post-doctoral
health and aging. The researchers at the                                    fellows who have earned a scholarship (close
Centre are distinguished by having the highest                              to 50%) has grown steadily; in fact, this figure
index of researcher training in Québec (source :                            doubled as compared to 1999-2000 (25%). The
FRSQ). Thus, the researchers at the Centre                                  Centre continues to be one of the largest sites
trained 145 graduate students and 11 post-                                  for interdiscipinary training in research in
doctoral fellows in 2000-2001. The interdisip-                              health and aging in the country.
inary nature of the training locale is evident                                                                                                              Students
                                                                                                                                                            Postdoctoral                             11
Students                                                                    Faculties                                                                       Doctorate                                73
                                            Masters                                                                                                         Masters                                  72
                                             46%                                                           Other faculties
                                                                                   Nursing                      7%                                          Total:                             156

                                                                                                                                                            Arts and Science                         57
                                                                                                                                    Arts and
                                                                                                                                    Science                 Medecine                                 66
                                                                                                                                      37%                   Nursing                                  21
  Doctorate                                         Post-doctoral                                                                                           Other faculties                          12
    47%                                                  7%                    Medicine
                                                                                42%                                                                         Total:                             156

 Ansaldo, Ana Ines         Forget, Julie               Leclerc, Chantal          Roy, Hélène
 Ayotte, Julie             Gagnon, Louis               Leclerc, Charles          Royle, Phaedra
 Bayard, Sophie            Giguère, Jean-François      Lecours, Sophie           Sassine, Rima
 Beauchemin, Marie-        Gilbert, Brigitte           Legault, Alain            Savard, Jacinthe
 Benoit, Monique
                           Gold, David
                           Gosselin, Nadia
                                                       Lemay, Marc
                                                       Lemoyne, Marisol
                                                                                 Sayad, Fouad
                                                                                 St-Amour, Dave
 Bergeron, Réjeanne        Gosselin, Nathalie          Lévesque, Johanne         St-Arnaud, Danielle
 Bherer, Louis             Gupta, Kunal                Li, Yue                   Sylvain, Hélène                                        Arabi, Hossein               Lavoie, Marc
 Cervellon, Marie-Cécile   Hallé, Paul                 Lippé, Sarah              Taller, Vanessa                                        Blanchet, Sophie             Ozaki, Keiko
 Courcy, André             Hamel, Caroline             Ménard, Judith            Tétrault, Marie-Hélène                                 Carpentier, Normand          Racette, Amélie
 Da Silva Machado,         Hammarrenger, Benoit        Monetta, Laura            Tremblay, Emmanuel                                     Carrié, Isabelle             Saumier, Daniel
 Maria                     Hardy, Paule                Morasse, Karine           Tripat, Gill                                           Clément, Juliette            Tremblay, Tania
 Dalla Bella, Simone       Karama, Sherif              Morin, Sylvie             Tsapkini, Kyrana                                       Khalfa, Stéphanie            Whatmough, Christine
 Duchesne, Geneviève       Lahaie, Annie               Nikolova, Rossitza        Tu, Mai Thanh                                          Laizner, Andréa
 Duong, Anh                Lalonde, Nadine-            Paquet, Catherine         Vanasse, Catherine
 Ellenberg, Dave           Michèle                     Perlak, Danuta            Villemagne, Jean
 Enriquez-Rosas, Adriana   Lavoie, Karyne              Précourt, Simon           Voyer, Philipp
 Fiset, Daniel             Lebel, Jordan               Provost, Ginette          Walter, Nathalie
 Fiset, Stéphanie          Leclaire, Hélène            Roigt, Delphine           Zhao, Jianying

                                                                                Archambault, Annie          Crête, Martine               Lachambre, Violaine            Poirier-Soucy, Johanne
                                                                                Aubé, François              Darveau, Bélise              Laflamme, Nathalie             Potvin, Stéphanie
                                                                                Babai, Myriam               De Grandmont, Anne           Lamarche, Huguette             Rossignol, Chantal
                                                                                Baillargeon, Estelle        Deninno, Annie               Lapalme, Guylaine              Roy, Julie
                                                                                Beauregard, Chantale        Desjardins, Jacinthe         Lapalme, Yannique              Roy, Kathleen
                                                                                Beausoleil, Natacha         Egurza, Irène                Lavoie, Luce                   Savard, Isabelle
                                                                                Bédard, Daniel              Emond, Stéphanie             Lefebvre, Annie-Claude         Séguin, Marie-Josée
                                                                                Bégin-Bertrand, Lydia       Garneau-B., Dominique        Lefrançois, Geneviève          St-Germain, Daphney
                                                                                Belzile, Johanne            Godin, Catherine             Marcil, Julie                  St-Pierre, Marie-Catherine
                                                                                Bertrand, Benoit            Gravel, Caroline             Marcotte, Karine               Sylvestre, Valérie
                                                                                Bérubé, Sonia               Guénette, Marie-Annick       Marinier, Julie-Andrée         Thibault, Maxime
                                                                                Bourbonnais, Anne           Heierle-Valero, Christina    Melançon, Geoffroy             Tinjust, David
                                                                                Briand, Guylaine            Hétu, Marie-Josée            Ménard, Catherine              Trinh Phan, Bao
                                                                                Brunelle, Julie             Houde, Wendy                 Meziane-Bellefquih, Layla      Vaillancourt, Sophie
                                                                                Cantini, Franca             Huot, Odette                 Paiement, Philippe             Vallières, Johanne
                                                                                Charest, Caroline           Hyde, Krista                 Paquette, Vincent              Vico, Mauricette
                                                                                Copti, Leila                Jacques, Marc-André          Paquin, Stéphanie
                                                                                Coron, Anne-Marie           La Haye, Dominique           Pelletier, Alexandrine

                                  Post-Doctoral Fellows

     Post-doctoral fellows make a major contri-         de l'Éducation du Québec. Dr. Clément is
     bution to research teams. These young              studying the comparisons between the organ-
     researchers, who have just completed their         ization of the brain for natural language and
     training, join laboratories for a few years.       that for musical language. Through its mathe-
     Many have applied for and obtained grants          matical properties, the study of music skills
     to do post-doctoral research from local or         enables us to uncover the organizing princi-
     international granting bodies. In addition,        ples that will serve for comprehension of
     through its Bourse des Gouverneurs, the            cognitive impairments in the elderly.
     Foundation of the Institute provides four
     scholarships for post-doctoral research. In        Guérette, Anne (Ph.D., Psychology, Université
     2000-2001, the Institute welcomed 11 post-         Laval; Dr. Sylvie Belleville's Laboratory)
     doctoral fellows. Some of their research proj-     Dr. Guérette was awarded a Bourse des
     ects are summarized below.                         Gouverneurs from the Foundation of the
                                                        Institute and from the Conseil québécois de la
     Blanchet, Sophie (Ph.D., Psychology, Université    recherche sociale. Dr. Guérette's work aims to
     de Caen, France; Dr. Sylvie Belleville's           evaluate the functional difficulties related to
     Laboratory). Dr. Blanchet received a grant         the presence of slight cognitive impairment
     from the Research Group in Experimental            and the impact of the personal variables in
     Neuropsycology, Université de Montréal.            the presentation of these impairments. She
     Dr. Blanchet's research aims to develop            is also interested in the effectiveness of a
     neuropsychological and electrophysiological        psychosocial intervention intended for these
     predictors of dementia of the Alzheimer's          people. The results of her studies will allow for
     type. Based on research dealing with memory        a better understanding of the needs of people
     and higher functions of individuals with           with slight cognitive impairment and for pro-
     slight cognitive impairments, Dr. Blanchet         posing interventions likely to favour their
     is attempting to identify tools for both           maintenance in the community.
     assessment and follow up that will be useful
     for clinicians.                                    Khalfa, Stéphanie (Ph.D., Neuropsychology,
                                                        Université Claude Bernard Lyon 1, France;
     Carpentier, Normand (Ph.D., Sociology,             Dr. Isabelle Peretz's Laboratory) Dr. Khalfa
     Université de Montréal; Dr. Francine               received a grant from the Canadian Health
     Ducharme's Laboratory) Dr. Carpentier              Research Institutes. Dr. Khalfa is studying cer-
     received a grant from the Canadian Health          tain fundamental aspects of cognitive func-
     Research Institutes. Dr. Carpentier's research     tioning, and more specifically the physiologi-
     deals with the issue of assistance sought by       cal mechanisms involved in the processing of
     family and friends of people suffering from        musical emotions. She is dealing with the
     Alzheimer's disease. Using the social networks     organization of emotions within the central
     approach and the perspective of the care tra-      nervous system through evoked brain poten-
     jectory, Dr. Carpentier is attempting to identi-   tials associated with the physiological meas-
     fy and analyze these behavioural processes in      urements related to the autonomous nervous
     order to provide essential benchmarks for the      system such as heart and respiratory rhythm,
     planning of intervention programs.                 skin temperature and electrodermal activity.

     Carrié, Isabelle (Ph.D., Biology of Aging,         Lavoie, Marc (Ph.D., Biomedical Sciences,
     Université Paris 7, Denis-Diderot; Dr. Guylaine    Université de Montréal; Dr. Isabelle Peretz,
     Ferland's Laboratory) Dr. Carrié received a        Sylvie Belleville and Martin Arguin's Laboratory)
     scholarship for excellence from the govern-        Dr. Lavoie was awarded a Bourse des
     ment of Québec and the Prix de l'Institut          Gouverneurs from the Foundation of the
     Danone, France. Dr. Carrié's work focuses on       Institute. Dr. Lavoie specializes in evoked
     the definition of the nutritional status of the    potentials applied to the study of the mecha-
     elderly and her goal is to make specific recom-    nisms associated with the execution of motor
     mendations to prevent problems of malnutri-        response in aging as well as in adult popula-
     tion in the elderly. Her current work deals with   tions with motor dysfunction. His work also
     the influence of the nutritional state of vita-    encompasses the study of motor disturbances
     min K on cerebral function based on a funda-       characterized in pathological aging, in
     mental (animal research) and clinical approach.    Parkinson's disease, and in dementia of the
                                                        Alzheimer type in order to lead to differential
     Clément, Juliette (Ph.D. Psychology, Université    diagnosis.
     René Descartes, Paris, France; Dr. Isabelle
     Peretz's Laboratory) Dr. Clément received a
     scholarship for excellence from the Ministère
                              Post-Doctoral Fellows

Massoud, Fahdi (M.D. Internal Medicine and           Saumier, Daniel (Ph.D., Psychology, Université
Geriatrics, Université de Montréal; Dr. Marie-       de Montréal, Dr. Martin Arguin and Dr. Howard
Jeanne Kergoat's Laboratory) Dr. Massoud             Chertkow's Laboratory) Dr. Saumier was
was awarded a Bourse des Gouverneurs from            awarded a Bourse des Gouverneurs from the
the Foundation of the Institute. Dr. Massoud's       Foundation of the Institute. Dr. Saumier's
work focuses on the characterization of pat-         research deals with certain mechanisms of
terns of reference as well as the clinical profile   cognition that can be affected in Alzheimer's
of users of the cognitive clinic. A better knowl-    disease. More specifically, Dr. Saumier is
edge of these aspects will allow for a greater       interested in the mechanisms associated with
understanding of what those referring know           the visual recognition of objects and faces
about their patients' cognitive impairments.         according to the cognitive neuropsychology
These results will allow for the establishment       approach. This work will proceed towards the
of training programs for referring physicians.       evaluation of a neuro-pharmacological treat-
                                                     ment that could slow the progression of these
Monchi, Oury (Ph.D., Neuronal Modelling,             problems in Alzheimer's disease.
Kings College, University of London, United
Kingdom; Dr. Julien Doyon's Laboratory)              Souchay, Céline (Ph.D., Psychology, Université
Dr. Monchi was awarded a Bourse des                  de Tours, France; Dr. Sylvie Belleville's
Gouverneurs from the Foundation of the               Laboratory) Dr. Souchay received a grant
Institute. Dr. Monchi's work deals with the          from the Canadian Health Research Institutes.
consequences of Parkinson's disease on the           Dr. Souchay's objective is to identify the
functioning of the prefrontal cortex through         cognitive indicators that will allow for distin-
functional neuroimaging. New advances in             guishing normal and pathological aging and
neuroimaging enable better understanding             to guide the treatment of memory impair-
of the contribution of the different cerebral        ments encountered in these populations.
zones in certain cognitive and learning              Two specific projects are under way: one on
processes. This work will allow for a better         the phenomenon of false recognition and the
detection of motor and cognitive impairments         other, on the different processes of control
in Parkinson's disease.                              involved in the recovery of information stored
                                                     in memory.
Ozaki, Keiko (Ph. D., Linguistics, University of
Sussex, Brighton, United Kingdom; Dr. Gonia
Jarema's Laboratory) Dr. Ozaki received a
grant from the Social Sciences and
Humanities Research Council of Canada.
Dr. Ozaki's research applies neurolinguistic
models to arrive at a better understanding of
problems of word comprehension in aphasia.
This research will contribute to identifying
universal models that will allow for an assess-
ment and treatment of lexical problems in
aphasia across languages.

                 Dr. Isabelle Carrié, Dr. Isabele Écuyer-Dab, Dr. Maud Champagne, Dr. Kyrana Tsapkini,
                 Dr. Christine Whatmough, Dr. Cara Tannenbaum, Dr. Anne Guérette, background
                 Dr. Normand Carpentier, Dr. Oury Monchy, Dr. Daniel Saumier, Dr. Sophie Blanchet
                                                                             Increase and Diversification of Funding

                                                       The year 2000-2001 was marked, first and                                    (11%), the Social Science and Humanities
                                                       foremost, by a major increase in the total                                  Research Council (8%) and several other
                                                       amount of scholarships and grants awarded                                   granting bodies.
                                                       to the Centre and its research teams. This
                                                       amount grew to more than $4.35 million, an                                  The three units in the Cognitive Neurosciences
                                                       increase of close to 30% as compared to the                                 and aging theme have been awarded the
                                                       total amount in 1999-2000. Of this total, close                             majority of the scholarship and grant dollars
                                                       to $1.19 million corresponds to scholarships                                (60%), while the theme Care and services for
                                                       and support for chercheurs-boursiers, while                                 the elderly and their families accounts for 24%
                                                       $3.16 million corresponds in large part to                                  of the total amount. The remainder of the
                                                       grants from federal (50%) and provincial                                    amounts obtained is divided relatively evenly
                                                       (50%) granting bodies. This amount includes                                 among the other research themes.
                                                       the $725 million infrastructure grant awarded
                                                       to the Centre by the FRSQ (see the table                                    The growth and diversification of the funding
                                                       illustrating how the infrastructure grant is                                for research at the Centre reflects both the
                                                       being used).                                                                impact of reinvestment in research in the
                                                                                                                                   country and a significant increase in the
                                                       While the Canadian Fund for Health Research                                 competitiveness of the researchers. It also
                                                       is one of the largest sources of scholarships                               bears witness to the increasing importance
                                                       and salary support (40%), the sources of                                    attributed to research in health and aging.
Mrs. Johanne Dupuis                                    grants are more diversified: Fonds de la
Mrs. Cathy Desmarais                                   recherche en santé du Québec (30%), Health
                                                       and Welfare Canada (12%), the Canadian
                                                       Health Research Institutes (12%), the
                                                       Canadian Foundation for Innovation (11%),
                                                       the Natural Sciences and Engineering Council

                         $450 000
                                                                    2000-2001 Grants
                         $400 000                                                                                                             Use of Infrastructure Funds
                                                                                                                                              of the Fonds de la recherche
                         $350 000
                                                                                                                                                   en santé au Québec
                         $300 000

                         $250 000                                                                                                       INCOME                         2000-2001

                         $200 000
                                                                                                                                        FRSQ GRANT                       723 100 $
                         $150 000
                                                                                                                                        OTHER INCOME                      59 844 $
                                                                                                                                        INTEREST                          32 876 $
                         $100 000
                                                                                                                                        TOTAL INCOME                    815 820 $
                          $50 000

                                    CQRS CIHR SSHRC NSERC EJLB   FCAR    FCI CHSRF HFSQ FRSQ IRSST NIH NHRDP ASC        HWC Others
                                                                                                                                        AND BENEFITS                     621 326 $
                       Research organisation
                                                                                                                                        TOTAL SALARIES                  621 326 $
 CQRS        Conseil québéçois de la recherche sociale
 SSHRC       Social Sciences and Humanities Research             $600 000                                                               OTHER COSTS
             Council of Canada                                                             2000-2001 Bursaries                          PERIODICALS AND VOLUMES             24 032 $
 NSERC       National Sciences and Engineering
             Research Council of Canada                          $500 000
                                                                                                                                        EQUIPEMENT                          59 468 $
 EJLB        The EJLB Foundation                                                                                                        RENT AND REPAIRS OFFICE EQUIPMENT   12 431 $
 FCAR        Fonds pour la Formation de Chercheurs
                                                                                                                                        POSTAGE                              6 404 $
             et l'Aide à la Recherche
                                                                  $400 00                                                               COMPUTER HARDWARE AND SOFTWARE      45 220 $
 CFI         Canada Foundation for innovation
 FRSQ        Fonds de la recherche en santé du Québec                                                                                   PROFESSIONAL FEES                    2 995 $
 CHSRF       The Canadian Health Services Research                                                                                      TELEPHONE AND LONG-DISTANCE          6 176 $
                                                                 $300 000
 HFSQ        Heart and Stroke Foundation of Quebec                                                                                      SCIENTIFIC ACTIVITIES                4 036 $
 CIHR        Canadian Institutes of Health Research                                                                                     MISCELLANEOUS                       26 281 $
 IRSST       Institut de recherche en santé et en sécurité       $200 000
                                                                                                                                        SEMINARS AND CONFERENCES             7 451 $
             du travail du Québec
 NIH         National Institute of Health
 NHRDP       National Health Research and Development            $100 000                                                               TOTAL OTHER COSTS               194 494 $
 ASC         Alzheimer Society of Canada                                                                                                TOTAL EXPENSES                  815 820 $
 HWC         Health and Welfare Canada                                  $0
                                                                             CQRS   CIHR   SSHRC NSERC FCAR   FRSQ NHRDP ASC   Others

       Meet the Research Professionals at the CRIUGM

The research teams at the Centre benefit from          Ishak, Marcelle
the contribution of several research profession-       (Diploma in Political Science and Economics)
als who serve as research assistants or project        Project – "Study of health and aging in
coordinators. These research professionals             Canada" (Drs. M-J. Kergoat and C. Wolfson;
constitute a key element in the day-to-day             Grant from Health and Welfare Canada.
work of the research programming as well as in         Contributions – Marcelle Ishak ensures the
the analysis of results and the management of          smooth operation of this vast study. She is in
databanks. They are also responsible for coor-         charge of follow up of the protocol, recruit-
dinating meetings with the participants and for        ment of interviewers, as well as links with the
facilitating exchanges between the researchers         Access to Information Commission to obtain
on the various teams. Finally, they often play a       certain essential information. In addition, she
major role in the financial management of the          contributes to budgeting and to maintaining
projects. Below is a description of some of the        ties with the partners in Ottawa. An important
professionals working in the Centre, which             aspect of her work has to do with verification
highlights the valuable contribution that they         of the data obtained. Finally, she is responsi-
make towards the research initiatives.                 ble for keeping the participants motivated.

Alix, Caroline (B. Sc., Psychology)                    Lepage, Émilie (M.Sc. Psychology)
Project – "Design of a model to assess the             Project – "Working memory and executive
effects of geriatric rehabilitation in hospitals"      functions in normal elderly people and those
(Dr. L. Demers; grant from the Réseau provin-          with impaired memory" (Dr. S. Belleville; grant
cial de recherche en adaptation-réadaptation           from the Canadian Health Research Institutes)
du Fonds de la recherche en santé du Québec)           Contributions – Émilie Lepage coordinates the
Contributions – Caroline Alix contributes to           laboratory, plans and organizes meetings, iden-
the design of a model assessing the effects of         tifes and contacts the study participants, car-
geriatric rehabilitation in hospitals by participat-   ries out evaluations and codes results. In addi-
ing in the review of the literature, leading meet-     tion, she contributes to managing the funds.
ings with elderly people and with experts, estab-
lishing and maintaining a reference system.            Raus, Anca (M.D., General Medicine)
                                                       Project – Cognition and Aging Consortium:
Eck, Karen (Ph.D. Psychology)                          Treatment of cognitive impairment in neu-
Projects - "Verbal communication deficits fol-         rodegenerative diseases (Drs. Y. Joanette and
lowing right-hemisphere damage: semantic               H. Chertkow, co-principal investigators; grant
processing of words, discourse and pragmatic           from Valorisation-Recherche Québec)
abilities" and "Recovery of language deficits          Contributions – Anca Raus coordinates this
following a CVA" (Dr. Y. Joanette in collabora-        major project which brings together some
tion with Dr. B. Ska; grant from the Canadian          thirty researchers from Québec. Among              Émilie Lepage
Health Research Institutes and from the                others, she coordinates the Consortium's           Marcelle Ishak
Canadian Foundation for Heart Disease)                 activities, promotes contacts and collabora-       Denise Trudeau
Contributions – Karen Eck contributes to the           tion among the researchers and maintains           Diane Goupil
coordination of these projects. Among others,          links with the pharmaceutical industry and         Anca Raus
she is working on the analysis of the literature,      with community-based associations.
meeting participants, and organizing team
meetings with students and with the group of           Trudeau, Denise (M.Sc. Nursing)
clinicians involved in these projects.                 Projects – "Shift towards ambulatory care:
                                                       Perceptions and expectations with regard to
Goupil, Diane (M.Sc. Biomedical Science)               services intended for natural caregivers"and
Project – Provincial registry of dementia for the      "Evaluative study of a health promotion pro-
cognition theme in the Réseau de recherche en          gram for caregivers of people living with
géronto-gériatrie du Québec (Dr. H. Chertkow,          dementia in a nursing home (CHSLD); (Dr. F.
coordinator, grant from the Réseau de recherche        Ducharme; grant from the Social Sciences and
en géronto-gériatrie du Québec of the Fonds de         Humanities Research Council of Canada, the
la recherche en santé du Québec)                       Fonds de la recherche en santé du Québec and
Contributions – Diane Goupil contributes to            the Alzheimers' Society of Canada).
the coordination of the project as she works in        Contributions – Denise Trudeau contributes to
close collaboration with the many researchers          the coordination of these research projects.
and others involved in it. She also sees to the        Among others, she is responsible for recruit-
development of the protocol, the writing of            ment of participants and interviewing; she
reports, the development of evaluation forms           sees to the application of the intervention,
and the supervision of other professionals             then analyzes the data. Denise Trudeau also
involved in the research.                              contributes to the dissemination of the results.
                          Top-notch expertise to serve the research teams

                    The research teams at the Research Centre          Network and Computer Support
                    rely upon an infrastructure that combines          Marc Filaretos (Network Administrator)
                    expertise with camaraderie. Thus, a staff of       Johane Landry (Computer Technician)
                    over ten technicians and professionals provide     The Research Centre boasts over 130 computer
                    support for the research activities and con-       stations linked by close to 10 hubs. The net-
                    tribute to making the Centre an efficient          work and computer support team is responsi-
                    workplace with a human face. An infrastruc-        ble for the planning and operation of this key
                    ture grant from the Centre du Fonds de la          tool for the researchers; the team also pro-
                    recherche en santé du Québec enables the sup-      vides logistic support for the research teams
                    port staff to contribute to the work carried       computers.
                    out by the research teams; indeed this support
                    is essential to the smooth operations at the       Mathematical and Statistical Support
                    Centre and to maintaining its national and         Francine Giroux (Mathematician-Statistician)
                    international influence.                           The teams in the Centre can count on a valu-
Doris Tétreault                                                        able resource in mathematics and statistics
Johane Landry       Technical Assistants to the Research               when they are planning experimental meth-
Colette Cerny       The 2000-2001 Team: Monique Brochu,                ods, constructing and managing data banks
Marianne Corre      Colette Cerny, Paule Samson, DorisTétreault.       and seeking advice and support in their statis-
Cathy Desmarais     (the following technical assistants left the       tical analyses, when applicable.
Monique Brochu      team during the year 2000-2001: Marie-
Paule Samson        Claude Charland, Sylvie Faucher and                Biomedical Engineering
Raymonde Thibault   Geneviève Vézina). The technical assistants        Hugo Dilhuydy (Biomedical Engineer)
Hugo Dilhuydy       make an essential contribution teams and to        Several research teams at the Centre use
Marc Filarétos      the effectiveness of the researchers' work. The    technologies that require biomedical engi-
Francine Giroux     assistants provide day-to-day support to the       neering support. In 2000-2001, active support
                    researchers in both their scientific and admin-    was provided to a confocal microscopy unit,
                    istrative tasks. Among others, they contribute     a microimagery processing unit, as well as
                    to the preparation of research grant proposals,    a laboratory of three 64-channel evoked
                    manuscripts and oral and poster presentations.     potentials units.

                    Secretary to the Scientific                        Administration of Grants and Scholarships
                    Directors and Administration                       Cathy Desmarais (Administrative Assistant)
                    Raymonde Thibault                                  The Administrative Unit of the Centre pro-
                    The secretary to the scientific directors and      vides support for the implementation and
                    administration assists the Director of             control of the Centre's administrative proce-
                    Research, the Associate Director of Clinical       dures. These include budget management for
                    Research, as well as the administrative direc-     grants and scholarships, as well as the annual
                    tor in their work. This secretary also provides    updating of the list that provides the Fonds
                    staffing on a day-to-day basis for the various     de recherche en santé du Québec with all
                    committees of the Research Centre, making          of the information required concerning the
                    this secretarial office a nerve centre and focal   researchers, the resources and the researcher
                    point for the Centre.                              training.

                    Documentation Support
                    Marianne Corre
                    Linked with the Documentation Centre of the
                    Institute, this service provides support for all
                    the research teams in the Centre, while also
                    taking responsibility for all the related man-
                    dates including rotation of the communica-
                    tions posted in the research passageway and
                    updating the information on the web site.


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