Osteogenesis Imperfecta (OI)

							DNA STANDS FOR DEOXYRIBONUCLEIC ACID. THIS IS JUST A
CHEMICAL WHICH IS PART OF THE HUMAN BODY. OFF THIS
STRAND OF DNA, YOU WILL SEE A BASE. THIS IS WHERE ALL OF
THE CHEMICALS SUCH AS ADDONINE AND GUYNINE WILL BE
FOUND.



                             HERE IS A BASE
                             WHERE THE
                             CHEMICALS WILL
                             COME OFF.
Genes are what make you up as a person. A hereditary
unit consisting of a sequence of DNA that occupies a
specific location on a chromosome and determines a
particular characteristic in an organism. Genes undergo
mutation when their DNA sequence changes
Genes are passed on through chromosomes
These come from the parents
The parents chromosomes which they pass onto
there child come from there parents and so on.
The genomics: GTL program is     The Human Project ends in 2003
DOE next step in genomics        with the completion of the human
building on data and resources   genetic sequence. A working draft
from the Human Genome            of the entire human genome
Project, the Microbial Genome    sequence was announced in June
Program, and systems biology     2000, with analyses published in
to accelerate understanding of   February 2001. An important
dynamic living systems for       feature of this project is the
energy and environmental         federal government long-
applications.                    standing dedication.
Osteogenesis Imperfecta (OI)
                 Osteogenesis Imperfecta is a
                  genetic condition which affects
                  the development of collagen, a
                  protein in the bone, skin and
                  other tissues.
                 In OI, defective collagen means
                  that the bones are extremely
                  fragile and can fracture as a
                  result of everyday movements.
                 Simple movements such as
                  opening a door or turning over in
                  one’s sleep can cause these
                  fractures.
How Is OI Passed On?
           The pattern of inheritance in many
            in many families with OI is
            autosomal dominant.
           Each and every child of an affected
            parent has a 50% chance of
            inheriting the faulty gene and of
            having OI.
           However, there are several hundred
            different mutations which can give
            rise to OI and many people with OI
            have no family history of the
            condition. This can be a result of
            spontaneous genetic mutation or
            been inherited in a different way.
How People Can Be Affected
              In children with severe OI, a
               specially adapted wheelchair may
               be their only chance of mobility as
               they are unlikely to stand or walk.
              People with OI may have blue
               whites to their eyes, discoloured or
               fragile teeth, loose joints, bruising
               and nose bleeds.
              They may also have problems with
               their hearing, with their spine and
               respiratory problems.
              The peak time for fractures is the
               first 15 years of life.
               Credits
   By
   Arjun Kumar
   Thomas Spurway
   Tony Mabbutt
   Stefan Bertin
   Dilir Habibi