Protein Structure by P-MarcelDekker

VIEWS: 38 PAGES: 5

Reflects current trends in the effort to solve new structures arising from genome initiatives. Details methods to detect and identify errors in the prediction of protein structural models and outlines challenges in the conversion of routine processes into high-throughput platforms.

More Info
									Protein Structure
Editor: Daniel Chasman
Table of Contents

Introduction


Structural Biology and Structural Genomics: A Federal Agency Perspective

John C. Norvell and Marvin Cassman


Determination


Producing Proteins
Aled M. Edwards, Cheryl H. Arrowsmith, Raymond Hui, Fabien Marino, Alexei Savchenko, Ken
Yamazaki, and Adelinda Yee


Crystallization of Membrane Proteins
R. Michael Garavito


Prospects for High-Throughput Structure Determination by X-Ray Crystallography
Frank von Delft, Charles D. Kang, and Duncan E. McRee


Prospects for High-Throughput Structure Determination of Proteins by NMR Spectroscopy
Ann E. Ferentz


Automated Molecular Replacement
Jorge Navaza and Pedro M. Alzari


Comparative Protein Structure Modeling
András Fiser and Andrej Sali


Rising Accuracy of Protein Secondary Structure Prediction
Burkhard Rost


Novel Fold and Ab Initio Methods for Protein Structure Generation
David J. Osguthorpe


Analysis


Identifying Errors in Three-Dimensional Protein Models
Brian D. Marsden and Ruben A. Abagyan


Comparative Analysis and Evolutionary Classification of Protein Structures
Liisa Holm


Automated Genome Functional Annotation for Structural Genomics
Sophia Tsoka and Christos A. Ouzounis


The Importance of Structure-Based Function Annotation to Drug Discovery
Susan M. Baxter, Stacy Knutson, and Jacquelyn S. Fetrow
The Protein Data Bank
Helen M. Berman, Philip E. Bourne, John Westbrook, and Christine Zardecki


The European Bioinformatics Institute Macromolecular Structure Database (E-MSD)
Dimitris Dimitropoulos, Peter A. Keller, Kim Henrick, John Ionides, Eugene Krissinel, Philip McNeil, and
Sameer S. Velankar


Applications for Drug Discovery


Molecular Docking in Structure-Based Design
Trevor W. Heritage


Use of Pharmacophores in Structure-Based Drug Design
Omoshile Clement and Adrea T. Mehl


The Structure of Human Interferon-ß-1a (Avonex®) and its Relation to Activity: A Case Study of the Use
of Structural Data in the Arena of Protein Pharmaceuticals
Adrian Whitty and Michael Karpusas


G-Protein-Coupled Receptors: Diverse Functions and Shared Mechanisms of Action Interpreted Through
the Structure of Rhodopsin
S. Roy Kimura and Daniel Chasman


Functional Assessment of Amino Acid Variation Caused by Single-Nucleotide Polymorphisms: A
Structural View
Daniel Chasman


Index
Description

Reflects current trends in the effort to solve new structures arising from genome initiatives. Details
methods to detect and identify errors in the prediction of protein structural models and outlines
challenges in the conversion of routine processes into high-throughput platforms.

								
To top