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Proanthozone to Treat Canine Atopic Dermatitis by gdw87570

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									            Proanthozone to Treat Canine Atopic Dermatitis
                                  L. BECO, Cabinet Vétérinaire, Spa, Belgium
T. OLIVRY, Department of Clinical Sciences, College of Veterinary Medicine, NC State University Raleigh, NC, USA


     Objectives                                                E v o lu tio n o f P r u r it u s S c o r e s
                                                                                                                         Summary
                                           10
        Open pilot study                                                                                                      8/22 dogs completed the study
                                            8      6 ,8
        Evaluation of the efficacy of a                                5 ,5                                                   10 were withdrawn because of
                                            6
        bioflavanol antioxidant complex                                                   3 ,8
                                                                                                       4 ,4                   increase of CADESI scores
                                            4
        (Proanthozone) to relieve signs                                                                                       after 2 or 4 weeks
                                            2
        of Atopic Dermatitis (AD) in                                                                                          3 were removed at the owner’s
        dogs                                0
                                                       0               2                   4            6                     request because of lack of
                                                                               W e e ks
                                                                                                                              improvement
                                                                                                                              1 was removed because of
     Outcome                               70          66,5
                                                                 Evolution of CADESI Scores
                                                                                                                              concurrent use of oral
        % of CADESI improvement            60                                                                                 glucocorticoids during the study
                                           50                                                               46,4
        % of PRURITUS improvement          40
                                                                        40,6               40,5                               5%
                                                                                                                        14%
        Overall assessment by clinician                                                                                                      Study co mple te d
                                           30                                                                                         36%
                                           20                                                                                                Incre as e d cade s i
        Overall assessment by owners
                                           10                                                                                                Lack o f impro v e me nt
                                            0
                                                        0                  2                   4              6                              C o ncure nt drug
                                                                                Weeks                                   45%

     Methods                                                                                                Owner
                                                              Overall improvement
        22 dogs with AD and CADESI                18                                                        Clinician
        score (v2) > 25                           16
                                                  14
                                                                                                                         Conclusions
        Proanthozone monotherapy at               12                                                                          Proanthozone does not
        the recommended dosage for 45      # Dogs
                                                  10
                                                                                                                              cause a reliable reduction
        days                                       8
                                                                                                                              of signs of AD in dogs
                                                   6
        Evaluation of CADESI and                   4
        PRURITUS scores after 2, 4 and             2                                                                          Side-effects were not seen
                                                   0
        6 weeks                                             Major       Moderate                 No




                                Study funded by animal Health Options, Golden, Colorado, USA

								
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