Joint Tissue Support

							      Joint Tissue Support
                                                                                          Excipients
                                                                                          Malic acid, tropical flavour (natural), trusil fruit punch flavour
                                                                                          (natural), citric acid, betatene, stevia, tapioca starch, silica
                                                                                          colloidal anhydrous

                                                                                          Pack size
                                                                                          200g

                                                                                          Dosage
                                                                                          1 level 5 mL metric spoonful twice daily (total 7.2g) in water
                                                                                          or juice, or as prescribed

                                                                                          Indications
                                                                                          May be beneficial for conditions
                                                                                          associated with the following:
                                                                                          • Osteoarthritis
                                                                                          • Connective tissue support

                                                                                          Interactions
                                                                                          Diabetes: It is possible that glucosamine may raise blood
                                                                                          glucose levels in a small percentage of patients. Monitor
                                                                                          blood sugar levels.
                                                                                          Contains ingredients of seafood origin and should not be
                                                                                          taken by people with seafood allergies.

                                                                                          Contraindications
                                                                                          N/A




      Formulations (each 7.2g)
      Glucosamine hydrochloride                                           600mg           Creatine monohydrate                                            600mg
      Glucosamine sulphate                                                600mg           Ascorbic acid                                                   600mg
      potassium chloride complex                                                          Citrus bioflavonoid extract                                     396mg
      Chondroitin sulphate                                                108mg           Calcium pantothenate                                             36mg
      Leucine                                                             240mg           Zinc (as amino acid chelate)                                         6mg
      Valine                                                              240mg           Copper (as gluconate)                                          600mcg
      Glycine                                                               1.75g         Selenium (as selenomethionine)                                  52mcg
      Lysine hydrochloride                                                720mg           Boron (as borax)                                                 2.2mg




*for further information regarding drug/nutrient interactions contact Orthoplex on 1800 077 113
       TECHNICAL INFORMATION


      CONNECTIvE TIssuE suppORT                                                           Chondroitin can competitively inhibit many of the degradative
                                                                                          enzymes that break down the cartilage matrix and synovial fluid
      Glycine, proline, lysine                                                            in osteoarthritis.[7]
      The major amino acids required for the production of collagen                       In repeated clinical studies oral chondroitin sulphate was
      and elastin are proline, lysine, glycine and hydroxy-proline.                       consistently effective in reducing osteoarthritis symptoms and
      Vitamin C is a major cofactor in the hydroxylation of proline                       was very well tolerated without local or systemic side effects.[8, 9]
      and lysine in the synthesis of connective tissue. The profound
      effect of scurvy on connective tissue and wound healing is                          MusCLE suppORT
      evidence for the role of vitamin C and bioflavonoids in these
      reactions. Other cofactors involved in the production of                            Branched chain amino acids
      connective tissue include zinc and copper.                                          The branched chain amino acids (BCAAs) valine and leucine,
                                                                                          play an important role in stress, energy and muscle metabolism.
      OsTEOARTHRITIs                                                                      They also have anabolic properties in that they promote protein
                                                                                          synthesis, decrease muscle catabolism, improve muscle
      Glucosamine                                                                         ergonomics and strengthen muscle weakness.
      Glucosamine, an amino-monosaccharide sugar, is formed
      in the body as glucosamine 6-phosphate. It is a precursor of                        Creatine Monohydrate
      the glycosaminoglycan (GAG) disaccharide unit and therefore                         Most of the body’s creatine levels are contained in skeletal muscle
      is a fundamental building block required for the biosynthesis of                    although some are present in the heart and brain. Creatine serves
      glycolipids, glycoproteins, glycosaminoglycans, and hyaluronate.                    to increase muscle energy levels by increasing the availability of
      Numerous in vitro studies have demonstrated that glucosamine                        adenosine triphosphate (ATP). Creatine supplementation has been
      stimulates the synthesis of proteoglycans and collagen by                           shown to increase muscle strength in patients with rheumatoid
      chondrocytes.[1] Osteoarthritis (OA) results when cartilage                         arthritis and stimulate muscle growth during rehabilitation
      breakdown exceeds the chondrocytes’ synthesising capacity.                          strength training.
      Therefore, providing exogenous glucosamine may help to
      increase matrix production.                                                         BONE suppORT
      It is believed that glucosamine’s role is potentiated by the
      presence of sulphate, which is also an essential component                          Boron
      of proteoglycans. Studies have shown glucosamine to be                              Boron is a trace mineral that is an essential component of the
      effective in the management of OA without severe side effects. [2-6]                matrix of human bone tissue. Boron is distributed throughout
                                                                                          the body with the highest concentrations being in bone and
      Chondroitin Sulphate                                                                dental enamel. It is needed for healthy bone and joint function
      Chondroitin sulphate is the most abundant glycosaminoglycan in                      due to its effect on calcium metabolism and the absorption
      articular cartilage. It is composed of repeating disaccharide units                 of calcium, magnesium and phosphorus. A diet deficient in
      of glucuronic acid and galactosamine sulphate and is a natural                      boron can cause a decrease in the absorption of calcium and
      component of several tissues in the body in addition to cartilage.                  can increase the excretion of both calcium and magnesium.




      References

      1.   Jimenez, S., The effects of glucosamine on human chondrocyte gene expression. Madrid, Spain" the Ninth Eular Symposium, 1996: p. 8-10.
      2.   Pujalte, J., et al., Double blind clinical efficacy and safety of intramuscular glucosamine sulphate in osteoarthritis.
           Arzneimittelforschung/Drug Res, 1990. 30(1).
      3.   Vajaradul, Y., Double blind clinical evaluation of intra-articular glucosamine in outpatients with osteoarthritis. Clin. Ther, 1999. 3: p. 336.
      4.   Vaz, A., Double blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthritis
           of the knee in outpatients. Curr Med Res Opin., 1999. 8: p. 145.
      5.   Wolfe, M., et al., Gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs. New Eng J Med., 1999. 340(24): p. 1888-1899.
      6.   Vaz, A., Double-blind clinical evaluation of the relative efficacy of glucosamine sulphate in the management of osteoarthritis of the knee in
           out-patients. Curr Med Res Opin., 1982. 8: p. 145-9.
      7.   Conte, A., et al., Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulphate. Arzneimittelforschung/Drug Res, 1997. 6.
      8.   Bucci, L., Chondroprotective agents: Glucosamine salts and chondroitin salts. Townsend Letters for Doctors., 1998. 1: p. 52-54.
      9.   Manner, T., et al., The antinociceptive effects of branched-chain amino acids: evidence for their ability to potentiate morphine analgesia.
           Pharmacol Biochem Behav, 1996. 53(2): p. 449-54.



*for further information regarding drug/nutrient interactions contact Orthoplex on 1800 077 113