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APPRAISING AN ARTICLE ON HARM

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					                     APPRAISING AN ARTICLE ON SAFETY OF DRUGS


SCENARIO

Your sister has been taking phenylpropanolamine since she was in high school
because of frequent congestion due to allergies. She carries it often with her,
buying “banigs” of it to make sure she can pop one in her mouth as soon as
symptoms begin. It really helps relieve symptoms and you would often ask for
one when you get colds.

Just a few years back, however, the news brought information about the risk of
PPA which raised your concern on this over the counter preparation. The
Department of Health issued several warnings and manufacturers began
reformulating it to maintain over the counter status.

Your sister continues to take it, although now she often tells you it doesn’t work
like it used to. You told her that she should be more concerned about its risk and
her answer was that she’d rather be able to breathe. You told her that you would
try to get some evidence on it and decided to search the internet to find out how
authorities made their decision. You found the article by Kernan et al on PPA
and the risk of hemorrhagic stroke published in the New England Journal of
Medicine in December of 2000. Luckily this journal provides free access to full
text for users from the Philippines and you were able to print out a copy.

A. Read the article and critically appraise its validity using the Appraisal Guides
   for an Article on Harm. Discuss the rationale for each criterion.

B. After appraising study validity, decide if you want to go on and read the rest of
   the article.

C. What will you say to your sister? Will you continue using it yourself or not?




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