MALACHITE GREEN ANALYSIS

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					 MALACHITE GREEN ANALYSIS


                         What is Malachite Green?
                         Malachite green (MG) is a triphenylmethane dye used in aquaculture throughout the
                         world for the treatment of parasitic and fungal infections in fish and shellfish. Compared
                         with licensed veterinary medicines, it is relatively inexpensive and freely available.
                         Leucomalachite green (LMG) is a metabolite of MG and can be found in fish as a result
                         of the use of MG.

                         The use of MG in aquatic food animals is highly restricted and banned in most countries
                         because of toxicological risks for human health. Due to public health concerns, MG has
                         been banned for use in food-producing animals in the EU, Canada & USA. However it is
                         still used in fish farming in some countries such as Vietnam & Chile.

                         In Australia, while MG is not a banned substance, it isn’t a licensed veterinary medicine
                         for food aquaculture and therefore its use in fish farming is illegal. In the EU, for
                         substances that are prohibited or not authorised such as MG, in order to harmonise
                         approaches MRPL’s (Minimum Required Performance Limits) have been established.
                         For the sum of MG and LMG in “meat of aquaculture products, a MRPL of 2ppb has
                         been established.” (Decision 2004/25/EC amending Decision 2002/657/EC).

                         How to Analyse for Malachite Green & Leucomalachite Green?
                         The analysis of residues of the antifungal drugs such as MG is based on the detection of
                         the parent drug or their metabolite(s) if the parent drug is rapidly metabolised. The
                         sample is blended, extracted, cleaned-up and analysed using LCMSMS techniques.
                         LCMSMS is the preferred instrument due to its greater sensitivity and specificity in
                         difficult matrices such as seafood.

                         Why use Advanced Analytical Australia?
                         Advanced Analytical is the leading antibiotic testing laboratory in Australia for fish and
                         other seafoods. It offers a comprehensive range of organic and inorganic chemical
                         contaminants for customers in the seafood industry. Our seafood testing capabilities
                         include antibiotics, antifungals, heavy metals and pesticides and PCBs.

                              Modern testing facilities & experienced analysts
                              Lowest limits of detection to meet EU and Australian regulatory limits
                              NATA Accredited laboratory
                              ISO/IEC 17025:1999 Quality Systems Accreditation
                              AQIS permits to import and test quarantine materials

                         Our experienced analysts use emerging technologies, and innovative and developing
                         methodologies to facilitate testing to the lowest levels of detection that will meet or
                         exceed regulatory guidelines.

                              We promise to deliver quality assured results on time and in full.

                         Please contact your nearest office for information on other residues and for a quote on
                         our comprehensive range of analytical services.

                            Brisbane: (07) 3862 2510:        andrew.bradbury@advancedanalytical.com.au
                            Sydney:      (02) 9888 9077:     attila.tottszer@advancedanalytical.com.au


                                  Advanced Analytical Australia Pty Ltd
Sydney:     11 Julius Avenue, North Ryde NSW 2113    Ph: 02 9888 9077 Fax:             02 9888 9577
Brisbane:   1/139 Sandgate Rd, Albion QLD 4010       Ph: 07 3862 2510 Fax:             07 3862 2520
                                      www.advancedanalytical.com.au

				
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