canada financial planning by harvey2


									 Fostering Genomic Research
and its Application to Agriculture
      Cindy Bell, Genome Canada &
    Jerome Konecsni, Genome Prairie

             May 9, 2007
              Canada Offers

• Strong Public-Private Partnership
• Less restrictive regulations on GMO’s
• Coordinated, well funded research
• Major producer/exporter of agricultural
   and forestry products
• Less interventionist agricultural policy
• Industrial scale farming and strong processing
Canada’s Biomass Capabilities
              Canada Needs

•   New feedstocks for bio-refining
•   Improved processing technologies
•   Crop adaptation plan
•   Closer ties with international research
•   Closer ties with industry
•   Access to markets that recognize
    importance of environment
Genomics Research
                Genome Canada
• Network of 6 Regional Genome Centres
• Funded over $700 million in genomic research (when
  include $800 million in cofunding = $1.5 billion investment)
• Program Principles:
   • Scientific excellence
   • GE3LS and SEBs
   • Sound management and financial controls
   • Co-funding – 50% of total project funding must come
     from other parties
   • Large scale projects – “Big Science” (average $10M)
                   Genome Canada Highlights

       • Launch and ramp-up of Centres
       • Identification of Excellent Research Teams (115 projects)
       • Science & Technology Platforms (6 platforms)
       • Implementation of New Management and Reporting Model
       • Co-Funding of all Activities
       • 2000 Scientists and Technicians Employed Coast to Coast
       • Change from Brain Drain to Brain Gain
2000            2001          2002              2003   2004              2005

       Genome          Comp I        Comp II                  Applied     Comp III
       Canada          projects      projects                 Health      projects
       launch          begin         begin                    projects    begin
Summary of Funding Sources for Genome
     Canada Approved Projects
                            Genome Canada

Institutional                         18%
         Industry/Private   Foreign
         11%                15%

                                            as at March 2007
 International Projects – Mechanisms for Support

          Investigator Initiated
             (regular application to Genome Canada with an
          international partner)

          Bilateral Competition
            (e.g. Genome Canada/Geñoma Espana)

          Community Led
            (e.g. Bovine project)

           International Consortium Initiative
            (e.g. SGC, P3G)

September 2005
                                  North American Conditional
                                  Mouse Mutagenesis Project

Goals             The International Knock-out Mouse Project is a
                  worldwide effort to generate knock-out mutations in
                  every gene in the mouse genome

Budget ($CAN)     $23.6 million
                  UC Davis & the European Conditional Mouse
Partners          Mutagenesis Project (EUCOMM), co-ordination with
                  KOMP through IKMC
                  Geoff Hicks, University of Manitoba
Project Leaders
                  Janet Rossant, Mount Sinai Hospital
     International Knockout Mouse Consortium
•LOI signed by NIH, European Commission & Genome Canada
•LOI expresses the principles for international collaboration in the
area of mouse mutagenesis including:

   •free & open release of data & resources generated;
   •sharing of production plans to minimize redundancy &
   duplication & to promote maximum efficiency;
   •coordination on archiving and distribution to ensure
   resources are readily accessible to the scientific community

•Steering Committee of PIs & funders formed to provide oversight
•Terms of Reference based on principles of LOI
•Working groups established for specific issues e.g. Repository
Practices Data & Resource Release; Technology Development.
    Strategic Planning Process
                 Position Paper
A position paper is expected to be a brief, non-
technical paper defining the importance of the
Strategic Research Theme, the problem to be
tackled, the current state of the science, the
infrastructure and human resources capacity
available in Canada, the total funding required
and the expected socio-economic outputs,
outcomes and impacts on the sector.
          Strategic Research Themes
•   Bioenergy & Value-Added Bioproducts
•   Agriculture – Animals (including fish)
•   Agriculture - Plants
•   Ecosystem Health in Response to Change and
    Environmental Monitoring
•   Sustaining & Enhancing Productivity of Crop, Forest and
    Ocean Industries
•   Ethical, Environmental, Economic, Legal and Social
    Aspects of Genomics Research (GE3LS)
•   Predisposition to Disease
•   Optimization of Therapies
•   Diagnostics
•   Disease Mechanisms
•   Nutrigenomics
          Agriculture & Fisheries Projects

Crop Research

  Abiotic Stress in Wheat & Canola                  $19.5 M
  Canola Seed Development                             7.5 M
  Functional Genomics in Arabidopsis                  1.6 M
  Potato Genomics                                     3.9 M
  Grape Genomics – Genoma Espana/Genome Canada         6.2 M
  Designing Oilseeds                                   6.8 M
  Crop Improvements in Temperate Climates – Grain      4.1 M
  Total Crop Research                                $49.6 M

Related Research
  Soil Microorganisms                                 5.9 M
                      Agriculture & Fisheries Projects

Animal Research
Infectious Diseases (Babiuk & Hancock)                                                                         26.9 M
Bovine Genome Sequencing (International Initiative)                                                            *58.6 M
    Total Animal Research                                                                                      $85.5 M

Aquaculture Research
Pleurogene Genoma Espana/Genome Canada (Douglas)                                                               $4.1M
Atlantic Cod Genomics (Symonds)                                                                                $12.9M
Genomics Research on Atlantic Salmon –GRASP (Davidson & Koop)                                                  $6.2M
Consortium for Genomics Research on Salmonids (cGRASP)                                                         $15M
     Total Aquaculture Research                                                                                $38.2M

* Total budget for the Bovine Sequencing Initiative was US $53 M changed in this table to approximate CAD for ease of addition. Genome
     Canada’s financial contribution to the initiative was US $5   M.
Plant Abiotic Stress: Example of
  International Collaborations


     USA                             EUR



               S OUTH


Current Projects
     Use of Genomic Tools for Crop
   Improvements in Temperate Climate

Dr. Brian Fowler, University of Saskatchewan

Project Summary
• Focus on three important crops: wheat, barley and rye
• Benefits anticipated will include: robust crops that will
  better withstand low temperatures; use less herbicides
  and energy to grow crops that are more cold resistant
  and more efficient use of crop moisture

Project Finances
• Total - $8.1 million; $4.1 million from Genome Canada;
  $3 million from Genome Prairie
     Designing Oilseeds for Tomorrow’s
Dr. Randall Weselake, University of Alberta
Dr. Wilf Keller, Plant Biotechnology Institute

Project Summary
• Use genomic technologies to develop canola with desired seed
  coat characteristics
• Decreased levels of anti-nutritional factors
• Enhance usefulness of canola seed leading to improved meal
  for new food and feed applications and increased oil content

Project Finances
• Total - $14.8 million; $6.8 million Genome Canada; $.6 million
  from Genome Prairie
         Future Applications of Genomics
There are a number of ways in which genomics
  can and will play a role in sustaining and
  growing the agricultural industry in Canada

  •   Yield improvements
  •   Yield security
  •   Support for breeding
  •   Gene function and regulation
  •   Metabolic pathway engineering
        Yield Improvements

Can be achieved by:

• Increasing specific types of oils
• Increasing oil content
                Yield Security

Genomics can play a role in addressing

• abiotic stress (frost, heat, drought &
  salinity) and
• biotic stress (strategies include the
  identification of factors that will increase a
  plant’s resistance to pathogens)
         Function and Regulation

Genomics can play a role in function and
 regulatory research, for example:

• Identify candidate genes involved in lipid or fatty
  acid biosynthesis
• Identify transacting factors that regulate the
  metabolic pathways

This could result in reaching the next level of oil
  content in oilseeds i.e., > 50%
         Metabolic Engineering

• Genomics can play a big role in identifying
  bottlenecks in metabolic pathways
• Industrial products such as hydroxy and epoxy
  fatty acids have been expressed in plants at
  levels around 15%
• In order to reach commercially viable levels of
  50%, the bottleneck will need to be resolved with
  a genomic approach
          Support for Breeding

• The identification of genetic markers can
  accelerate plant breeding and reduce
  development time
Activities related to EPO BIO Flagships

 Canada has activities that parallel
  the EPOBIO flagships

 • Oils
 • Polymers
 • Cell Walls
         OILS – Platform Crops

Brassica carinata

• Later to mature than canola; heat and drought
  tolerant and large seed size.
• Protein content 10% higher and oil content 10%
  lower than canola.
• Low fiber (large yellow seed).
• High allyl glucosinolate and high/low erucic acid
• Great potential to develop as a platform for bio-
  diesel, bio-pesticides or wax esters.
               OILS - continued

Brassica juncea

•   Grown both as mustard and as canola.
•   Earlier to mature than canola (B. napus)
•   Heat & drought tolerant; shatter resistant.
•   Large yellow seed - low fiber meal.
•   Excellent potential as:
     • Bio-fumigant (high allyl glucosinolate)
     • Bio-lubricant

Camelina sativa (false flax or German sesame)

   •   Grown in Europe for centuries.
   •   Low input requirement
   •   Suitable for short growing seasons
   •   Great potential as molecular farming or bio-diesel
           Other Oils Research

• Increasing oil content in brassica – more cost
  effective biodiesel
• Molecular engineering of high value fatty acids
  for use in industrial products such as hydoxy,
  epoxy and wax esters
             CELL WALLS

• Triticale as a crop platform
• Cross between wheat and rye
• Agronomic performance (higher yields,
  adaptability, stability of yield and supply,
  designer platform)
• Limited use in human food chain; more
  potential for industrial use
              CELL WALLS

Bioprocesses of Flax Residues for
  Biochemicals and Biomaterials

  Development of superior biocatalyst for
  processing of plant fibre
  Development of new enzyme-retting cocktail
• Development of flax fibre PP composites
  with optimized mechanical properties

Triticale and Waxy Starch Wheat

• Industrial feed for a grain biorefinery
  producing ethanol
• Carbohydrates as precursors to platform
  chemicals – e.g., Polymers
• DDGS as source of value-added industrial
     Other Canadian
  Programs/Initiatives to
Support Commercialization
and Genomics Applications
Canadian Biomass Innovation Network
• Network of federal researchers, program
  managers, policymakers and expert
  advisors, together with partners from
  industry, universities and provincial
• Funding C$7.8M (05/06)
Agricultural Bioproducts Innovation Program
 • A multi-year program (2006-2011) supporting
   networks of scientific research to accelerate
   commercialization of bioproducts and bioprocesses

 • This C$145M program funds network/cluster
   activities, research, development and technology
   transfer/commercialization focussed on:

    • Better Feedstocks

    • Better Processing

    • Product Diversification
       Process          BioCar Initiative           Chemical
       optimization                                 engineering
       Value added                                  Paint, varnish,
       bio-                                         coatings,
       composites                                   composites

                                  Improved                 DCX
       Ford                       functionality
                                                           Pulp Mfg
      Grower                                               Fibre
       Part                                                Processor
                                 Product design
                                 Predictive model
Project Investment $18 Million   Bio-composite
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             Alberta Bioplastics Network

• Development of fundamental science relationships
  between starting materials:
     •   physico-chemical modification
     •   processing conditions
     •   structural hierarchies
     •   resultant physical functionality.
• Development of scale-up technologies for
  laboratory-scale processes
• Market research, investment & business
• Environmental and economic policy and regulations
Capital Programs for Commercial Ventures

• Sustainable Technologies Development Canada
     • C$500 million for second generation bio-fuels
• Agri-Opportunities Program
     • C$134 million over 5 years
• Alberta Biorefinery Commercialization and Market
  Development Program
• AgWest Bio – early stage seed capital
• Ontario Research Demonstration\Innovation
  Commercialization program (over $200 Million)
          ABIC 2007
     September 23-26, 2007

A conference with a program extending over
   two and a half days with plenary and
           concurrent sessions

The AgBio Exhibition, where participants will
    have the opportunity to promote their
businesses and products in a professionally
 presented and marketed exhibition display

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