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					406            Molecular Biosciences

in one of 32 primary career fields. Opportunities to         sions Officer in the Aerospace Studies Department at          Bruce W. Draper, Ph.D., Assistant Professor
fly are better than ever. Whether you are piloting the       CSUS (916) 278-7315 for information.                          JoAnne Engebrecht, Ph.D., Associate Professor
F-22 fighter, supervising 150 aircraft maintainers on                                                                      Carol A. Erickson, Ph.D., Professor
the flightline, or caring for sick personnel in the          Naval ROTC                                                    Marilynn E. Etzler, Ph.D., Professor
emergency room, you will be rewarded knowing                 Department of Naval Science                                   Oliver Fiehn, Ph.D., Associate Professor
that you are making a difference.                            152 Hearst Gymnasium, UC Berkeley                             Andrew Fisher, Ph.D., Professor
                                                             Berkeley, CA 94270-3640                                           (Chemistry)
AFROTC at UC Berkeley                                        (510) 642-3551;                  Charles S. Gasser, Ph.D., Professor
AFROTC Detachment 85                                                                                                       Kenneth B. Kaplan, Ph.D., Associate Professor
                                                             UC Davis students may participate in the Navy and
176 Hearst Gym, Berkeley, CA, 94720-3610                                                                                   John A. Kiger, Ph.D., Professor
                                                             Marine Corps ROTC program at UC Berkeley. The
(800) 852-5747 or (510) 642-3572;                                                                                          Ian Korf, Ph.D., Assistant Professor
                                                             program is 4 years long and includes courses and;                                                                                                J. Clark Lagarias, Ph.D., Professor
                                                             weekly professional development laboratories (drill)                                                                                           Julie A. Leary, Ph.D., Professor
                                                             at UC Berkeley. Students normally compete for
To receive hands-on leadership and management                                                                              Francis J. McNally, Ph.D., Associate Professor
                                                             national scholarships as high school seniors,
practice, freshmen and sophomores take a one-hour                                                                          Richard W. Michelmore, Ph.D., Professor (Vegetable
                                                             although interested students may enroll as freshmen
academic course and a two-hour Leadership Labora-                                                                              Crops; Medical Microbiology and Immunology)
                                                             or sophomores and compete for scholarships based
tory each week; juniors and seniors take a three-                                                                          Diana G. Myles, Ph.D., Professor
                                                             on successful participation in the program. A student
hour course plus the lab. All units can be used as                                                                         Jeanette E. Natzle, Ph.D., Associate Professor
                                                             who satisfactorily completes an ROTC program and
elective credit towards graduation. See the Military                                                                       Jodi Nunnari, Ph.D., Professor
                                                             is awarded a degree from UC Davis receives an
Sciences course listings in the UC Berkeley catalog.                                                                       Edmund R. Powers, Ph.D., Professor
                                                             active duty commission as a Second Lieutenant in the
Classes are held during the fall and spring semesters                                                                      Raymond L. Rodriguez, Ph.D., Professor
                                                             U.S. Marine Corps or an Ensign in the U.S. Navy.
and the curriculum includes the history of airpower,                                                                       Lesilee S. Rose, Ph.D., Associate Professor
                                                             Navy option students take the following courses:              Jonathan M. Scholey, Ph.D., Professor
leadership and management topics, communication
skills, and national security issues.                        Freshman year:                                                Irwin H. Segel, Ph.D., Distinguished Professor
                                                                                                                           Henning Stahlberg, Ph.D., Associate Professor
Between the sophomore and junior years, cadets                 NS 1         Introduction to Naval Science                  Daniel A. Starr, Ph.D., Assistant Professor
compete to attend a four- or six-week field training           NS 2         Sea Power and Maritime Affairs                 Michael D. Toney, Ph.D., Professor
program at a designated Air Force base. This com-            Sophomore year:                                                   (Chemistry)
petitive program consists of physical conditioning,                                                                        David K. Wilson, Ph.D., Professor
outdoor survival training, career and aircraft orienta-        NS 3         Leadership and Management
tions and an evaluation of leadership potential.               NS 10        Naval Ship Systems I                           Secondary Section Members
Additional optional training opportunities are avail-        Junior year:                                                  John J. Harada, Ph.D., Professor
able during the summer months and include the                  NS 12A Navigation and Naval Operations I                    Wolf-Dietrich Heyer, Ph.D., Professor
Royal Air Force Exchange Program, Pentagon Intern-             NS 12B Navigation and Naval Operations II                   Stephen C. Kowalczykowski, Ph.D., Distinguished
ships, Jump School and Glider Training at the Air            Senior year:                                                     Professor
Force Academy, and summer job shadowing. Stu-                  NS 401 Naval Ship Systems II                                William J. Lucas, Ph.D., Professor
dents are also encouraged to participate in optional           NS 412 Leadership and Ethics                                Brian Mulloney, Ph.D., Professor
orientation flights, base visits, and community ser-                                                                       Sharman O'Neill, Ph.D., Professor
vice projects throughout the school year.                    In lieu of NS401, NS10, NS12A and NS12B,                      Pamela A. Pappone, Ph.D., Professor
                                                             Marine Corps students participate in Marine Semi-             Martin L. Privalsky, Ph.D., Professor
AFROTC at CSU Sacramento                                     nars and complete MA154, History of Littoral War-             Steven M. Theg, Ph.D., Professor
California State University Sacramento                       fare and MA20, Evolution of Warfare (or a                     Larry N. Vanderhoef, Ph.D., Professor
Public Service Building, Room 208                            designated equivalent).                                       Martin Wilson, Ph.D., Professor
6000 J Street                                                Scholarship students are required to complete a num-
Sacramento, CA 95819-6094                                    ber of other courses at Davis, including one year
                                                                                                                           Emeriti Faculty
(916) 278-7315                                               each of calculus, physics, and English, and one               Ronald J. Baskin, Ph.D., Professor Emeritus
The CSUS Department of Aerospace Studies offers              quarter each of computer science, and military his-           Don M. Carlson, Ph.D., Professor Emeritus
two-, three-, or four-year programs leading to a com-        tory or national security policy.                             Sterling Chaykin, Ph.D., Professor Emeritus
mission in the U.S. Air Force. About 30 percent of                                                                         James S. Clegg, Ph. D., Professor Emeritus
                                                             Interested students should contact the Department of
the corps commute to CSUS from UC Davis. All                                                                               Eric E. Conn, Ph.D., Professor Emeritus
                                                             Naval Science at UC Berkeley at the address above
course work (12 or 16 semester units) is completed                                                                            Academic Senate Distinguished Teaching Award,
                                                             to obtain information and apply.
on the CSUS campus. Drills and courses are nor-                                                                               UC Davis Prize for Teaching and Scholarly
mally offered on Tuesdays, Wednesdays, and Thurs-                                                                             Achievement
days. Field training is conducted at an active Air                                                                         Richard S. Criddle, Ph.D., Professor Emeritus
Force base during part of the summer, normally
between the student’s sophomore and junior years.
                                                             Molecular Biosciences                                         John H. Crowe, Ph.D., Professor Emeritus
                                                                                                                           David W. Deamer, Ph.D., Professor Emeritus
                                                                                                                           Gordon J. Edlin, Ph.D., Professor Emeritus
Upon completion of the program (integrated with                                                                            Richard H. Falk, Ph.D., Professor Emeritus
UC Davis’ quarter system) and all requirements for a         See Veterinary Medicine, School of,                           Leslie D. Gottlieb, Ph.D., Professor Emeritus
bachelor’s degree, cadets are commissioned as sec-           on page 502.                                                  Melvin M. Green, Ph.D., Professor Emeritus
ond lieutenants in the Air Force and serve a mini-                                                                         Robert D. Grey, Ph.D., Professor Emeritus,
mum of four years on active duty. Graduates who                                                                               Academic Senate Distinguished Teaching Award
are qualified and are selected may enter pilot or                                                                          Jerry L. Hedrick, Ph.D., Professor Emeritus
navigator training after graduation, or serve in a
specialty consistent with their academic major, indi-
                                                             Molecular and                                                    Distinguished Graduate Mentoring Award
                                                                                                                           Mark G. McNamee, Ph.D., Professor Emeritus
vidual goals, and existing Air Force needs. Gradu-
ates may request a delay of entry to active duty to
                                                             Cellular Biology                                              Carl W. Schmid, Ph.D., Professor Emeritus
                                                                                                                           Che-Kun J. Shen, Ph.D., Professor Emeritus
continue their education or may apply for Air Force                                                                        Larry R. Sprechman, Ph.D., Senior Lecturer Emeritus
sponsored graduate study to begin immediately                (College of Biological Sciences)                              Paul K. Stumpf, Ph.D., Professor Emeritus
upon entry to active duty. Due to firm scheduling            Michael E. Dahmus, Ph.D., Chairperson of the
requirements for the AFROTC program, students are            Department
                                                                                                                           Affiliated Faculty
encouraged to work closely with their academic                                                                             Benjamin F. Edwards, Ph.D., Lecturer
advisers in planning their academic program.                 Department Office. 149 Briggs Hall
                                                                                                                           Kenneth L. Hilt, Ph.D., Lecturer
                                                             (530) 752-3611;
AFROTC offers 3-year and 2-year scholarships to                                                                            Deborah A. Kimbrell, Ph.D., Lecturer
qualified students. Applications are accepted in any         Faculty                                                       Judith A. Kjelstrom, Ph.D., Academic Coordinator/
academic discipline. Express scholarships are cur-                                                                            Lecturer
                                                             Primary Members
rently available for qualified students majoring in                                                                        Leann L. Lindsay, Ph.D., Lecturer
electrical engineering and meteorology. Express              Peter B. Armstrong, Ph.D., Professor                          Larry Z. Morand, Ph.D., Lecturer
scholarships pay up to $15,000 annually in tuition           Enoch Baldwin, Ph.D., Associate Professor                     Alan B. Rose, Ph.D., Lecturer
and fees, $480 per year in textbooks, and $150               Sean M. Burgess, Ph.D., Associate Professor                   Carol M. Rubin, Ph.D., Lecturer
per month stipend.                                           Kenneth C. Burtis, Ph.D., Professor                           Mark F. Sanders, Ph.D., Lecturer
                                                             Judy Callis, Ph.D., Professor                                 Leigh D. Segel, Ph.D., Lecturer
Applications should normally be no later than the            Frederic L. Chedin, Ph.D., Assistant Professor
first quarter of a student’s sophomore year. Juniors,                                                                      Molecular and Cellular Biology offers three major
                                                             R. Holland Cheng, Ph.D., Professor
seniors, and graduate students may also apply                                                                              programs: Biochemistry and Molecular Biology, Cell
                                                             Michael E. Dahmus, Ph.D., Professor
under certain conditions. Contact the Unit Admis-                                                                          Biology, and Genetics.
                                                             Roy H. Doi, Ph.D., Distinguished Professor

                                        Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2009-2010 offering in parentheses
     General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience
                                                                                                                                       Molecular and Cellular Biology                            407

The Biochemistry and Molecular                                     which principles derived from the physical sciences,                   technology companies, medicine, and all the health
                                                                   genetics, biochemistry, molecular biology and physi-                   sciences. It is also an excellent background for stu-
Biology Major Program                                              ology are integrated in the study of living cells and                  dents wishing to continue their education in a gradu-
The Biochemistry and Molecular Biology major intro-                emphasizes the experimental nature of the study of                     ate program, a teacher-training program, medical
duces students to the chemistry of living organisms                cell biology.                                                          school, veterinary school, or other professional
and the experimental techniques that are used to                                                                                          schools.
                                                                   Career Alternatives. The major provides an
probe the structures and functions of biologically
                                                                   excellent background for students wishing to enter                     B.S. Major Requirements:
important molecules. Students who enjoy both chem-
                                                                   postgraduate and professional programs in biologi-
istry and biology and who are comfortable with                                                                                                                                                        UNITS
                                                                   cal, health sciences or veterinary sciences; for stu-
quantitative approaches to problem solving will find                                                                                      Preparatory Subject Matter ..............56-65
                                                                   dents pursuing careers involving teaching or
this major a rewarding field of study.
                                                                   research in the biological sciences; for students inter-                 Biological Sciences 2A-2B-2C ................14
The Program. The biochemistry and molecular                        ested in careers in the biotechnological or pharma-                      Chemistry 2A-2B-2C or 2AH-2BH-
biology program begins with the four-course, upper                 ceutical industries; or for students interested in                       2CH....................................................15
division common curriculum that provides an intro-                 careers related to the administrative, legal or com-                     Chemistry 8A-8B or 118A-118B-
duction to the principles of biochemistry, genetics,               mercial aspects of biomedical science.                                   118C ............................................... 6-12
and cell biology. Majors then take a comprehensive                                                                                          Mathematics 16A-16B-16C or 1
and rigorous laboratory course to familiarize them                 B.S. Major Requirements:                                                 7A-17B-17C or 21A-21B-21C............. 9-12
with the most important aspects of biochemical                                                                                 UNITS        Physics 7A-7B-7C .................................12
research. Additional upper division courses in bio-                Preparatory Subject Matter.............. 60-69                         Depth Subject Matter .......................48-49
chemistry and molecular biology examine detailed
                                                                     Biological Sciences 2A-2B-2C................ 14                        Biological Sciences 101, 102, 103,
aspects of these subjects. Students are also required
                                                                     Chemistry 2A-2B-2C............................. 15                     104 ....................................................13
to take courses in other biological sciences and a full
                                                                     Mathematics 16A-16B-16C or                                             Molecular and Cellular Biology 160L,
year of physical chemistry.
                                                                     17A-17B-17C or 21A-21B-21C ...........9-12                             164 ......................................................7
Career Alternatives. The biochemistry and                            Physics 7A-7B-7C................................. 12                   Evolution and Ecology 100 ......................4
molecular biology program provides a solid scien-                    Statistics 13 or 100 (recommended) ......... 4                         One course from Molecular and Cellular
tific background for students seeking a research,                    Chemistry 8A-8B or 118A-118B-                                          Biology 161 (recommended) or 121 .........3
teaching, or service career in the life sciences. Posi-              118C ...............................................6-12               Two courses from Molecular and Cellular
tions are open to biochemists in bio-medical, bio-                 Depth Subject Matter ....................... 42-43                       Biology 162, 163, 182 or Evolution and
technological, pharmaceutical, agricultural research                                                                                        Ecology 102 ....................................... 6-7
and chemical industries. Also, university-affiliated                 Biological Sciences 101, 102, 103,
                                                                     104 ................................................... 13             Statistics 100 .........................................4
research laboratories, hospital laboratories, and                                                                                           Restricted Electives ................................11
government-sponsored research facilities provide                     Molecular and Cellular Biology 140L ....... 5
                                                                     Two courses from Molecular and Cellular                                  Upper division courses in genetics or other
employment opportunities. The major provides excel-                                                                                           fields relevant to the student's interest
lent preparation for advanced study in graduate or                   Biology 143, 144, or 145 ...................... 6
                                                                     Molecular and Cellular Biology 121 or                                    chosen in consultation with the adviser. No
professional schools.                                                                                                                         more than 4 units of 192, 193, 198, or
                                                                     161 ..................................................... 3
                                                                                                                                              199 may be used for credit in this category.
B.S. Major Requirements:                                             Molecular and Cellular Biology 150
                                                           UNITS     and 150L, or 163 and 164 ..................5-6                       Total Units for the Major ..............104-114
                                                                     Select at least 10 additional units from the                         Master Adviser. J.E. Natzle
Preparatory Subject Matter.............. 53-57
                                                                     following: Chemistry 107A, 107B; Evolution
  Biological Sciences 2A-2B-2C................ 14                    and Ecology 100, 150; Microbiology 102,                              Advising Center for the major is located in 156
  Chemistry 2A-2B-2C or 2AH-2BH-2CH ... 15                           150, 170; Molecular and Cellular Biology                             Briggs Hall (530) 752-0202.
  Mathematics 16A-16B-16C, 17A-17B-17C or                            120L, 123, 124, 126, 138, 143, 144, 145,                             Graduate Study. See Genetics (A Graduate
  21A-21B-21C ................................... 9-12               148, 150/150L, 158, 160L, 162, 163,                                  Group), on page 302.
  Physics 7A-7B-7C ................................. 12              164, 178, 182, 191; Neurobiology,
  Statistics 13, 32, 100 (recommended) or                            Physiology, and Behavior 100, 101, 103,                              Courses in Molecular and Cellular
  102................................................... 3-4         112, 131, 160, 161; Pathology,                                       Biology (MCB)
Depth Subject Matter ....................... 53-54                   Microbiology, and Immunology 126, 126L;
                                                                     Plant Biology 111, 111D, 113, 113D, 152.                             Lower Division Courses
  Biological Sciences 101, 102, 103,
  104.................................................... 13         No more than 4 units of research (193,                               10. Introduction to Human Heredity (4)
  Chemistry 118A-118B-118C or 128A-                                  194H, 199) may be used for credit in this                            Lecture—3 hours; discussion—1 hour. Topics in
  128B-128C, 129A-129B ................. 12-13                       category ............................................. 10            human heredity and human gene structure and func-
  Chemistry 107A-107B ............................ 6               Total Units for the Major .............. 102-112                       tion, including the genetic basis of human develop-
  Molecular and Cellular Biology 120L, 121,                                                                                               ment, causes of birth defects, mental retardation,
                                                                   Master Adviser. D.G. Myles
  123, 124............................................ 16                                                                                 genetic diseases, sexual determination, develop-
  Restricted Electives ................................. 6         Advising Center for the major is located in 156                        ment, and behavior. GE credit: SciEng.—III. (III.)
    6 units of upper division courses in                           Briggs (530) 752-0202.                                                 Sanders
    biological sciences or chemistry relevant to                   Graduate Study. See Cell and Developmental                             99. Special Study (1-5)
    the student's interest chosen in consultation                  Biology (A Graduate Group), on page 174.                               Independent study—3-15 hours. Prerequisite: con-
    with the adviser. Students are encouraged                                                                                             sent of instructor. (P/NP grading only.)
    to obtain additional laboratory experience;                    The Genetics Major Program
    however, no more than 3 units of 192, 193                      The Genetics major provides a broad background in                      Upper Division Courses
    or 199 research may be counted toward                          the biological, mathematical, and physical sciences                    120L. Biochemistry Laboratory (6)
    restricted elective units.                                     basic to the study of heredity, gene expression and                    Laboratory—10 hours; lecture—2 hours; labora-
Total Units for the Major .............. 106-111                   evolution. The major is sufficiently flexible to accom-                tory/discussion—1 hour. Prerequisite: Biological Sci-
Master Adviser. C.S. Gasser                                        modate students interested in the subject either as a                  ences 103 (may be taken concurrently). Introduction
                                                                   basic discipline in the biological sciences or in terms                to laboratory methods and procedures employed in
Advising Center for the major is located in 156                    of its applied aspects such as biotechnology, medi-                    studying biochemical processes. Designed for stu-
Briggs (530) 752-9032.                                             cine, and agriculture.                                                 dents who need experience in the use of biochemi-
Graduate Study. See Biochemistry and Molecular                     The Program. The genetics program begins with                          cal techniques as laboratory tools.—I, II, III. (I, II, III.)
Biology (A Graduate Group), on page 165.                           the four-course, upper division core curriculum that                   Fairclough, Hilt, Lagarias, Lindsay, Liu, L. Morand,
                                                                   provides an introduction to the principles of genetics,                Rubin
The Cell Biology Major Program                                     biochemistry, and cell biology. Students then take                     121. Molecular Biology of Eukaryotic Cells
The Cell Biology major program provides students                   additional upper division courses in specialized                       (3)
with a comprehensive understanding of the cell, the                areas of modern genetics including gene expression,                    Lecture—3 hours. Prerequisite: Biological Sciences
basic structural and functional unit of all living organ-          evolution, development, human genetics and genom-                      101 and 103. Structure, expression, and regulation
isms.                                                              ics, as well as a laboratory course in the principles                  of eukaryotic genes. Chromosome structure and rep-
The Program. To understand living organisms, the                   of genetics. Additional upper division courses in bio-                 lication; gene structure, transcription, and RNA pro-
biologist must understand the cell. Hence, cell biol-              logical sciences, as well as internship/research                       cessing; protein synthesis and translation control;
ogy lies at the core of the biological sciences. Stu-              coursework can be chosen to fulfill required elective                  development, immune system, and oncogenes. Not
dents taking this major gain a solid foundation in                 units.                                                                 open for credit to students who have completed
biological principles. The major emphasizes how                    Career Alternatives. The genetics degree pro-                          Molecular and Cellular Biology 161.—II, III. (II, III.)
cellular organization and function contribute to the               vides suitable preparation for a wide variety of                       Burgess, Dahmus, Gasser, Harmer
development, maintenance and reproduction of                       careers, including teaching, research, work with bio-
adult organisms. The major illustrates the ways in
                                         Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2009-2010 offering in parentheses
      General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience
408            Molecular and Cellular Biology

123. Behavior and Analysis of Enzyme and                     150. Developmental Biology (4)                                impact of these disciplines on research in the biolog-
Receptor Systems (3)                                         Lecture—4 hours. Prerequisite: Biological Sciences            ical sciences. Social impacts of genomic research.—
Lecture—3 hours. Prerequisite: Biological Sciences           101 and concurrent enrollment in course 150L.                 III. (III.) Korf
103. Introduction to the principles of enzyme kinetics       Analysis of the mechanistic basis for animal develop-         190C. Undergraduate Research Conference
and receptor-ligand interactions with emphasis on            ment with a focus on experimental evidence and the            (1)
metabolic regulation and data analysis. Topics               relevant fundamental experimental strategies. Fertil-         Discussion—1 hour. Prerequisite: upper division
include simultaneous equilibria, chemical and                ization and early development, morphogenesis and              standing and consent of instructor; concurrent enroll-
steady-state kinetics, allosteric enzymes, mulitreac-        patterning, cell differentiation, regulation of cell pro-     ment in course 193 or 199. Presentation and discus-
tant systems, enzyme assays, membrane transport              liferation and tissue growth.—I. (I.) Armstrong,              sion of current research by faculty and students. May
and computer-assisted simulations and analyses.—I,           Edwards                                                       be repeated for credit. (P/NP grading only.)—I, II,
III. (I, III.) I. Segel, Wilson                              150L. Laboratory in Developmental Biology                     III. (I, II, III.)
124. Macromolecular Structure and                            (1)                                                           191. Introduction to Research (1)
Function (4)                                                 Laboratory—3 hours. Prerequisite: concurrent enroll-          Seminar—1 hour. Prerequisite: Biological Sciences
Lecture—4 hours. Prerequisite: Biological Sciences           ment in course 150. Experiments using live embryos            102 (may be taken concurrently) or consent of
103, Chemistry 107B, 118C. An in-depth investiga-            and histological slide preparations of developing             instructor. Various topics in molecular and cellular
tion into protein and nucleic acid structure and ther-       embryos will be used to investigate and illustrate the        biology including biochemistry, genetics, and cell
modynamics and how these properties influence                basic mechanisms of animal development. (P/NP                 biology will be discussed, along with ways under-
their biological functions. Key examples of important        grading only.)—I. (I.) Edwards                                graduates can participate in research projects of fac-
functional classes of these molecules will be exam-          158. Undergraduate Seminar in                                 ulty members. May be repeated for credit. (P/NP
ined. Not open for credit to students who have com-          Developmental Biology (2)                                     grading only.)—I, II, III. (I, II, III.)
pleted course 122 or Chemistry 108.—I, III. (I, III.)        Seminar—2 hours. Prerequisite: upper division                 192. Internship (1-12)
Baldwin, Stahlberg                                           standing in the biological sciences or a related disci-       Internship—3-36 hours. Prerequisite: completion of
126. Plant Biochemistry (3)                                  pline. Student reports on current topics in cell biol-        84 units and consent of instructor. Technical and/or
Lecture—3 hours. Prerequisite: Biological Sciences           ogy with emphasis on integration of concepts,                 practical experience on and off campus, supervised
103 or 105. The biochemistry of important plant              synthesis, and state-of-the-art research approaches.          by a member of the Section of Molecular and Cellu-
processes and metabolic pathways. Discussion of              Reviews of literature and reports of undergraduate            lar Biology faculty. (P/NP grading only.)
methods used to understand plant processes, includ-          research may be included. May be repeated for
                                                                                                                           193. Advanced Research (3)
ing use of transgenic plants. (Same course as Plant          credit. (P/NP grading only.)—I, II, III. (I, II, III.)
Biology 126.)—II. (II.) Abel, Callis                                                                                       Laboratory—6 hours; discussion—1 hour. Prerequi-
                                                             160L. Principles of Genetics Laboratory (4)                   site: upper division standing, completion of an upper
138. Undergraduate Seminar in                                Laboratory—6 hours; lecture—2 hours. Prerequisite:            division Molecular and Cellular Biology laboratory
Biochemistry (1)                                             Biological Sciences 101. Laboratory work in basic             course and consent of instructor. Research project
Seminar—1 hour. Prerequisite: Biological Sciences            and molecular genetics including gene mapping and             carried out under the supervision of a faculty spon-
103. Discussion of the historical developments of            isolation of mutants. Not open for credit to students         sor. Discussion and analysis of results and proposed
modern biochemistry or current major research prob-          who have completed Genetics 100L.—I, II, III. (I, II,         experiments on a weekly basis with faculty sponsor.
lems. May be repeated twice for credit when topic            III.) Britt, Kiger, Kimbrell, Natzle, Rose, Sanders,          May include presentation of a seminar to a research
differs. (P/NP grading only.)—I, II, III. (I, II, III.)      Sundaresan                                                    group. May be repeated for credit. (P/NP grading
140L. Cell Biology Laboratory (5)                            161. Molecular Genetics (3)                                   only.)—I, II, III. (I, II, III.)
Lecture—2 hours; laboratory—6 hours; discussion—             Lecture—3 hours. Prerequisite: Biological Sciences            194H. Research Honors (3)
1 hour. Prerequisite: Biological Sciences 104 (may           101, Biological Sciences 102 may be taken concur-             Independent study—9 hours. Prerequisite: 6 units of
be taken concurrently). Exercises illustrating the prin-     rently. Molecular mechanisms for propagation and              course 193 and/or 199 with faculty director; senior
ciples of cell biology with emphasis on light micros-        expression of the genome in eukaryotic and prokary-           standing; GPA of at least 3.250; consent of Section.
copy.—II. (II.) Kaplan, Nunnari                              otic model organisms. How genetic and molecular               Honors project. Continuation of an intensive, individ-
142. Advanced Cell Biology: Contractile                      tools, both classical and modern, are applied to the          ual laboratory research project in biochemistry,
and Motile Systems (4)                                       study of gene structure, function, and regulation. Not        genetics, or cell biology culminating with the presen-
Lecture—3 hours; term paper. Prerequisite: Biologi-          open for credit to students who have completed                tation of the work in a written thesis and in a semi-
cal Sciences 102, 104 (may be taken concurrently);           course 121.—II. (II.) Burgess, Gasser, Powers                 nar. (P/NP grading only.)
Mathematics 16B. Advanced cell biology with                  162. Human Genetics (3)                                       197T. Tutoring in Molecular and Cellular
emphasis on molecular, biophysical and cellular              Lecture—3 hours. Prerequisite: course 161 (pre-               Biology (1-5)
properties of contractile and motile systems.                ferred) or 121, 164. Human molecular genetic vari-            Tutorial—2-6 hours. Prerequisite: upper division
143. Cell Biophysics (3)                                     ation, molecular basis of metabolic disorders,                standing, completion of course to be tutored, and
Lecture—3 hours. Prerequisite: Biological Sciences           chromosome aberrations and consequences, analy-               consent of instructor. Assisting the instructor in one of
101, 102, 103, 104. Physical principles underlying           sis of the human genome, and computational tech-              the section’s regular courses by tutoring individual or
observations and mechanisms of cell motility. Orga-          niques of genetic analysis.—I. (I.) Chedin, Sanders           small groups of students in a laboratory, in voluntary
nization of biomolecules into higher order subcellu-         163. Developmental Genetics (3)                               discussion groups, or other voluntary course activi-
lar structures that function as macromolecular               Lecture—3 hours. Prerequisite: course 161 (pre-               ties. May be repeated for credit. (P/NP grading
machines. Examples include cytoskeletal filaments,           ferred) or 121, course 164. Current aspects of                only.)—I, II, III. (I, II, III,)
polymer-motor systems, neurites, axonemes and                development genetics. Historical background and               198. Directed Group Study (1-5)
mitotic spindles.—I. (I.) Scholey                            current genetic approaches to the study of develop-           Variable—1-5 hours. Prerequisite: consent of instruc-
144. Mechanisms of Cell Division (3)                         ment of higher animals.—II. (II.) Natzle, L. Rose             tor. (P/NP grading only.)
Lecture—3 hours. Prerequisite: Biological Sciences           164. Advanced Eukaryotic Genetics (3)                         199. Special Study for Advanced
101, 102, 104. The molecules and mechanisms that             Lecture—3 hours. Prerequisite: course 161 or 121.             Undergraduates (1-5)
allow eukaryotic cells to coordinate cell growth,            The five basic operations of genetic analysis: muta-          Independent study—3-15 hours. Prerequisite: con-
DNA replication, segregation of chromosomes and              tion, segregation, recombination, complementation,            sent of instructor. (P/NP grading only.)
cell division.—II. (II.) McNally                             and regulation. Emphasis on the theory and practice
145. Assembly and Function of Cell                           of isolating and analyzing mutations, as well as              Graduate Courses
Signaling Machinery (3)                                      understanding mechanisms underlying both Mede-                200A. Current Techniques in Cell Biology (2)
Lecture—3 hours. Prerequisite: Biological Sciences           lian and epigenetic inheritance.—III. (III.) Burgess          Lecture—2 hours. Prerequisite: graduate standing;
101, 102, 104. Molecular basis of cell signaling,            178. Undergraduate Seminar in Molecular                       Biological Sciences 104 and course 141 or the
including positioning of cellular machinery, compo-          Genetics (1)                                                  equivalent courses. Current techniques used in cell
nents of various signaling pathways, and down-               Seminar—1 hour. Prerequisite: upper division stand-           biology research including microscopy, spectros-
stream effects of signaling on cell adhesion, cell           ing, completion of Biological Sciences 101, course            copy, electrophysiology, immunochemistry, histology,
differentiation, and programmed cell death.—III.             160L, and completion or concurrent enrollment in              organelle isolation, calorimetry, tissue culture and
(III.) Erickson                                              course 161. Discussion of current topics in molecular         gel electrophoresis. Lectures are presented by
148. Undergraduate Seminar in Cell                           genetics to show advanced applications of basic               experts on each technique, with an emphasis on pit-
Biology (2)                                                  principles and to highlight professional career               falls to avoid when using the technique. (Same
Seminar—2 hours. Prerequisite: upper division                opportunities. May be repeated for credit. (P/NP              course as Cell and Developmental Biology 200.) (S/
standing in the biological sciences or a related disci-      grading only.)—I, II, III. (I, II, III.)                      U grading only.)—I. (I.) Beck
pline. Student reports on current topics in cell biol-       182. Principles of Genomics (3)                               200B. Current Techniques in Biochemistry
ogy with emphasis on integration of concepts,                Lecture—3 hours. Prerequisite: Biological Sciences            (2)
synthesis, and state-of-the-art research approaches.         101, course 121 or 161. Fundamentals of genom-                Lecture—2 hours. Prerequisite: Biological Sciences
Reviews of literature and reports of undergraduate           ics, including structural genomics, functional genom-         103 and course 120L or the equivalent. Current
research may be included. May be repeated for                ics, proteomics, and bioinformatics, focusing on the          techniques used in biochemical research including
credit. (P/NP grading only.)                                                                                               protein and carbohydrate analyses, immunochemis-
                                        Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2009-2010 offering in parentheses
     General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience
                                                                Molecular, Cellular, and Integrative Physiology (A Graduate Group)                                         409

try, recombinant DNA methods, electrophoretic and             mended. Analysis of the early events of development         in molecular and cellular biology including biochem-
chromatographic methods. (S/U grading only.)—II.              including: germ cells and other stem cells, gameto-         istry, genetics, and cell biology. May be repeated
(II.) Kaplan                                                  genesis, meiosis, imprinting, fertilization, genetically-   for credit. (S/U grading only.)—I, II, III. (I, II, III.)
200C. Current Techniques in Biophysics (2)                    engineered organisms, egg activation and establish-         291. Current Progress in Molecular and
Lecture—2 hours. Prerequisite: graduate standing;             ment of embryonic polarity with focus on cellular           Cellular Biology (1)
Biological Sciences 102 or 104 or the equivalent.             events including gene regulation and cell signaling.        Seminar—1 hour. Prerequisite: graduate standing or
Current techniques in biophysics research including           Offered in alternate years.—(I.) Myles                      consent of instructor. Seminars presented by guest
diffraction, magnetic resonance spectroscopy, calo-           252. Cellular Basis of Morphogenesis (4)                    lecturers on subject of their own research activities.
rimetry, optical spectroscopy, and electrophysiology.         Lecture/discussion—3 hours; term paper. Prerequi-           May be repeated for credit. (S/U grading only.)—I,
(Same course as Biophysics Graduate Group 200.)               site: course 150. Development of form and structure;        II, III. (I, II, III.) Draper
(S/U grading only.)—II. (II.)                                 morphogenetic movement, mechanisms of cellular              294. Current Progress in Biotechnology (1)
220L. Advanced Biochemistry Laboratory                        motility, cell adhesion, intercellular invasion, interac-   Seminar—1 hour. Prerequisite: graduate standing or
Rotations (5)                                                 tion of cells and tissues in development. Offered in        consent of instructor. Seminars presented by guest
Laboratory—15 hours. Prerequisite: course 221A                alternate years.—(II.) Armstrong, Tucker                    lecturers on subjects of their own research activities.
(may be taken concurrently) and 120L or the equiva-           255. Molecular Mechanisms in Pattern                        May be repeated for credit. (Same course as Chemi-
lent. Two five-week assignments in biochemistry               Formation and Development (3)                               cal Engineering 294.) (S/U grading only.)—I, II, III.
research laboratories. Individual research problems           Lecture—3 hours. Prerequisite: graduate standing or         (I, II, III.) Kjelstrom, McDonald, Rodriguez
with emphasis on methodological/procedural expe-              consent of instructor; introductory background in           295. Literature in Molecular and Cellular
rience and experimental design. May be repeated               developmental biology and/or genetics recom-                Biology (1)
twice for credit.—I, II, III. (I, II, III.) Chedin, Trimmer   mended. Genetic and molecular analysis of mecha-            Seminar—1 hour. Prerequisite: graduate standing
221A. Physical Biochemistry (4)                               nisms that control animal development after                 and consent of instructor. Critical reading and evalu-
Lecture—4 hours. Prerequisite: Biological Sciences            fertilization. Establishment of embryonic axes, cell        ation of current literature in molecular and cellular
103, Chemistry 107B, 108, and 128C, 129C, or                  fate and embryonic pattern; induction, apoptosis, tis-      biology disciplines. Papers will be presented and
118C or the equivalent or consent of instructor.              sue patterning. Critical reading of current literature      discussed in detail. May be repeated for credit. (S/
Chemical and physical properties of biomacromole-             in C.elegans, Drosophila, and mouse genetic model           U grading only.)—I, II, III. (I, II, III.) Baldwin, Fisher,
cules emphasizing the interrelationship of molecular          systems. Offered in alternate years.—III. Natzle,           Myles, Privalsky, Radke, Wilson
interactions and thermodynamic properties as deter-           Rose
                                                                                                                          298. Group Study (1-5)
minants of higher order structure. The use of NMR             256. Cell and Molecular Biology of Cancer
                                                                                                                          Variable—1-5 hours. Prerequisite: consent of instruc-
and crystallography in determining macromolecular             (2)
                                                                                                                          tor. (S/U grading only.)
structure.—I. (I.) Baldwin, Stahlberg, D. Wilson              Lecture—1 hour; term paper. Prerequisite: course in
                                                              cell or developmental biology (e.g., course 150,            299. Research (1-12)
221B. Mechanistic Enzymology (3)
                                                              141, 163, or Biological Sciences 104). Analysis at          Independent study—3-36 hours. (S/U grading only.)
Lecture—3 hours. Prerequisite: undergraduate level
organic and biological chemistry, one course in               the cellular and molecular levels of the regulation of      Professional Course
physical chemistry recommended. Analysis of                   normal and neoplastic tissue growth; tumor dissemi-
                                                              nation; identification and characterization of onco-        390. Methods of Teaching (1)
organic enzyme reaction mechanisms and the explo-
                                                              genic agents; characterization of oncogenes and             Discussion—1 hour. Prerequisite: graduate standing
ration of enzyme catalyzed reactions.—I. (I.) Bald-
                                                              tumor-suppressor genes.—I. (I.) Armstrong                   and consent of instructor. Practical experience in the
win, Fiehn, Toney
                                                              257. Cell Proliferation and Cancer Genes                    methods and problems of teaching biochemistry/
221C. Molecular Biology (4)                                                                                               genetics/cell biology. Includes analysis of texts and
Lecture—4 hours. Prerequisite: course 221A or the                                                                         supporting material, discussion of teaching tech-
equivalent. Pass 1 restricted to graduate students in         Lecture—1.5 hours; seminar—1.5 hours. Prerequi-
                                                                                                                          niques, preparing for and conducting discussion and
biochemistry and molecular biology, microbiology,             site: course 221C and 221D or the equivalent.
                                                                                                                          laboratory sections, formulating examinations under
or genetics. Structure and organization of DNA and            Genetic and molecular alterations underlying the
                                                                                                                          supervision of instructor. Participating in the teaching
chromatin; DNA replication, repair and recombina-             conversion of normal cells to cancers, emphasizing
                                                                                                                          program required for Ph.D. May be repeated for
tion; transcription and RNA processing; protein bio-          regulatory mechanisms and pathways. Critical read-
                                                                                                                          credit. (S/U grading only.)—I, II, III. (I, II, III.)
synthesis and turnover; transcriptional and post-             ing of the current literature and development of
transcriptional control mechanisms; examples from             experimental approaches.—I. (I.) Carraway, Radke
eukaryotic and eubacterial cells, and viruses. (Same          258. Seminar in Development (2)
course as Genetics 201C.)—III. (III.) Baldwin, H.
Chen, Heyer, Korf, Stewart
                                                              Seminar—2 hours. Prerequisite: consent of instructor.
                                                              Reports and discussion on embryology, morphogen-
                                                                                                                          Molecular, Cellular,
221D. Cellular Biochemistry (4)                               esis, and developmental mechanisms. May be
                                                              repeated for credit.—II. (II.) Armstrong, Erickson
                                                                                                                          and Integrative
Lecture—3 hours; discussion—1 hour. Prerequisite:
Biological Sciences 102, course 221A or the equiv-            259. Literature in Developmental Biology                    Physiology (A
alent or consent of instructor. Molecular structure and       (1)
biophysical properties of cell membranes; organelle           Seminar—1 hour. Prerequisite: consent of instructor.        Graduate Group)
biogenesis and trafficking; signal transduction,              Critical presentation and analysis of recent journal
metabolism and metabolic regulation; cytoplasmic              articles in developmental biology. May be repeated
organization, biophysics of the cytoskeleton and              for credit. (S/U grading only.)—I, II, III. (I, II, III.)   Catherine VandeVoort, Ph.D., Chairperson of the
force-generating mechanisms, mechanism of intracel-           Armstrong, Erickson, Myles                                  Group
lular transport and mitosis; cell reproduction and the        263. Biotechnology Fundamentals and                         Group Office. 313 Life Sciences
cell cycle.—II. (II.) McNally, Nunnari, Powers,               Application (2)                                             (530) 752-9092;
Scholey, Starr                                                Lecture—2 hours. Prerequisite: Biological Sciences
241. Membrane Biology (3)                                     101, 102, Microbiology 102, graduate student in             Faculty
Lecture—3 hours. Prerequisite: Biological Sciences            good standing. To train graduate students interested
102, 103, 104 or consent of instructor. Advanced              in a biotechnology career track; to learn recombi-          Thomas Sean H. Adams, Ph.D., Research
topics on membrane biochemistry and biophysics.               nant DNA, rate processes of biological systems, opti-           Physiologist (USDA WHNRC)
Relationship of the unique properties of biomem-              mization of bioreactor performance, practical issues        Thomas E. Adams, Ph.D., Professor (Animal Science)
branes to their roles in cell biology and physiology.         in biotechnology, and some case studies of the              Steven E. Anderson, Ph.D., Associate Researcher
(Same course as Biophysics 241.)—III. (III.) Longo,           development of biotechnology products and pro-                  (Physiology and Membrane Biology)
Voss                                                          cesses. Offered in alternate years.—II. (II.) McDon-        Joseph F. Antognini, M.D., Professor
                                                              ald, Privalsky, Rodriguez, Vandergheynst                        (Anesthesiology and Pain Medicine)
248. Seminar in Cell Biology (2)                                                                                          Trish J. Berger, Ph.D., Professor (Animal Science)
Seminar—2 hours. Prerequisite: consent of instructor.         282. Biotechnology Internship (7-12)                        Bers, Donald M., Ph.D., Professor
Discussion of recent literature on the physical and           Internship—21-36 hours. Prerequisite: graduate                  (Medical Pharmacology)
chemical aspects of organization and function of liv-         standing and consent of instructor. Research at a bio-      Sue Bodine, Ph.D., Professor (Exercise Science)
ing systems, topics of current interest in ultrastructure     technology company or interdisciplinary cross-col-          Ann C. Bonham, Ph.D., Professor
and function of cells. Organizational and functional          lege lab for a minimum of 3 months as part of the               (Medical Pharmacology and Toxicology)
properties of the molecular and cellular levels of bio-       Designated Emphasis in Biotechnology Program. (S/           Laura Borodinsky, Ph.D., Assistant Professor
logical systems. May be repeated for credit.—I.               U grading only.)—I, II, III. (I, II, III.) Dandekar             (Physiology & Membrane Biology)
Myles                                                         290C. Research Conference (1)                               Robert Brosnan, Ph.D., Assistant Professor
251. Molecular Mechanisms in Early                            Discussion—1 hour. Prerequisite: graduate standing              (VM: Surgical & Radiological Sciences)
Development (3)                                               and consent of instructor. Presentations and critical       Peter M. Cala, Ph.D., Professor
Lecture—3 hours. Prerequisite: graduate standing or           discussions of faculty and graduate student research            (Physiology and Membrane Biology)
consent of instructor; introductory background in                                                                         Christopher C. Calvert, Ph.D., Professor
developmental biology and/or cell biology recom-                                                                              (Animal Science)
                                        Quarter Offered: I=Fall, II=Winter, III=Spring, IV=Summer; 2009-2010 offering in parentheses
     General Education (GE) credit: ArtHum=Arts and Humanities; SciEng=Science and Engineering; SocSci=Social Sciences; Div=Social-Cultural Diversity; Wrt=Writing Experience