MOLECULAR AND CELLULAR BIOLOGY

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					            MOLECULAR AND CELLULAR BIOLOGY
Volume 11                               August 1991                                               No. 8



                                        GENE EXPRESSION
   Diverse Gene Sequences Are Overexpressed in Werner Syndrome Fibroblasts
        Undergoing Premature Replicative Senescence. Shunichi Murano, Ray
        Thweatt, Robert J. Shmookler Reis, Richard A. Jones, Elena J. Moerman,
        and Samuel Goldstein ................................................          3905-3914
   Binding Sites of the 9- and 14-Kilodalton Heterodimeric Protein Subunit of the
        Signal Recognition Particle (SRP) Are Contained Exclusively in the Alu Do-
        main of SRP RNA and Contain a Sequence Motif That Is Conserved in Evo-
        lution. Katharina Strub, Jennifer Moss, and Peter Walter ...............       3949-3959
   The Neurospora crassa cyt-20 Gene Encodes Cytosolic and Mitochondrial Valyl-
        tRNA Synthetases and May Have a Second Function in Addition to Protein
        Synthesis. Anne R. Kubelik, Beatrice Turcq, and Alan M. Lambowitz....          4022-4035
   HSP47: a Tissue-Specific, Transformation-Sensitive, Collagen-Binding Heat Shock
        Protein of Chicken Embryo Fibroblasts. Kazunori Hirayoshi, Hitoshi
        Kudo, Hajime Takechi, Akira Nakai, Akihiro Iwamatsu, Kenneth M.
        Yamada, and Kazuhiro Nagata.......................................             4036-4044
   A Negative Regulator of HO Transcription, SIN1 (SPT2), Is a Nonspecific DNA-
        Binding Protein Related to HMG1. Warren Kruger and Ira Herskowitz ...          4135-4146
   The Mitochondrial Uncoupling Protein Gene in Brown Fat: Correlation between
        DNase I Hypersensitivity and Expression in Transgenic Mice. Bert B.
        Boyer and Leslie P. Kozak ...........................................          4147-4156
   Analysis of cDNAs of the Proto-Oncogene c-src: Heterogeneity in 5' Exons and
        Possible Mechanism for the Genesis of the 3' End of v-src. Thambi Dorai,
        Joan B. Levy, Lily Kang, Joan S. Brugge, and Lu-Hai Wang.............          4165-4176
   Identification of mRNAs Associated with Programmed Cell Death in Immature
        Thymocytes. Gregory P. Owens, William E. Hahn, and J. John Cohen....           4177-4188
   Isolation and Characterization of a New Mutant Human Cell Line Unresponsive
        to Alpha and Beta Interferons. Joseph John, Roslyn McKendry, Sandra
        Pellegrini, David Flavell, Ian M. Kerr, and George R. Stark..............      4189-4195
   The Herpes Simplex Virus Type 1 Thymidine Kinase Is Expressed in the Testes of
        Transgenic Mice under the Control of a Cryptic Promoter. Raya Al-Shawi,
        Joanne Burke, Helen Wallace, Cheryl Jones, Stephen Harrison, David
        Buxton, Stephen Maley, Ann Chandley, and John 0. Bishop .............          4207-4216
   Striking Similarities between the Regulatory Mechanisms Governing Yeast Mat-
        ing-Type Genes and Mammalian Major Histocompatibility Complex Genes.
        Jocelyn D. Weissman and Dinah S. Singer..............................          4228-4234

                              TRANSCRIPTIONAL REGULATION
   The Early Response Gene NGFI-C Encodes a Zinc Finger Transcriptional Activa-
       tor and Is a Member of the GCGGGGGCG (GSG) Element-Binding Protein
       Family. Seth D. Crosby, John J. Puetz, Kelli S. Simburger, Timothy J.
       Fahrner, and Jeffrey Milbrandt ........................................         3835-3841
   The B-Cell and Neuronal Forms of the Octamer-Binding Protein Oct-2 Differ in
       DNA-Binding Specificity and Functional Activity. C. L. Dent, K. A.
       Lillycrop, J. K. Estridge, N. S. B. Thomas, and D. S. Latchman .........        3925-3930
                                                                              Continued on following page
Continued from preceding page

    Displacement of Xenopus Transcription Factor IIIA from a 5S rRNA Gene by a
         Transcribing RNA Polymerase. Frank E. Campbell, Jr. and David R.
         Setzer ..............................................................          3978-3986
    Transcription Factors Nuclear Factor I and Spl Interact with the Murine Colla-
         gen al(I) Promoter. Michael C. Nehls, Richard A. Rippe, Linda Veloz,
         and David A. Brenner...............................................            4065-4073
    The Immunosuppressant FK-506 Specifically Inhibits Mitogen-Induced Activation
         of the Interleukin-2 Promoter and the Isolated Enhancer Elements NFIL-2A
         and NF-AT1. Sunandita S. Banerji, Janey N. Parsons, and Michael J.
         Tocci ...............................................................          4074 4087
    Antagonism between Retinoic Acid Receptors. Matthias Husmann, Jurgen
         Lehmann, Birgit Hoffmann, Thomas Hermann, Maty Tzukerman, and
         Magnus Pfahl........................................................           4097-4103
    Cyclic Amplification and Selection of Targets (CASTing) for the Myogenin Con-
         sensus Binding Site. Woodring E. Wright, Michael Binder, and Walter
         Funk ...............................................................           4104 4110
    SHI, a New Yeast Gene Affecting the Spacing between TATA and Transcription
         Initiation Sites. Elizabeth M. Furter-Graves, Rolf Furter, and Benjamin
         D. Hall .............................................................          4121-4127
    Functional Characterization of the Human Hypoxanthine Phosphoribosyltrans-
         ferase Gene Promoter: Evidence for a Negative Regulatory Element. Diego
         E. Rinc6n-Limas, David A. Krueger, and Pragna 1. Patel ................        4157-4164
    A Complex Regulatory DNA Element Associated with a Major Histocompatibility
         Complex Class I Gene Consists of Both a Silencer and an Enhancer.
         Jocelyn D. Weissman and Dinah S. Singer..............................          4217-4227
    Identification of an Enhancer Required for the Expression of a Mouse Major Uri-
         nary Protein Gene in the Submaxillary Gland. Hyeung Jin Son, Karen
         Shahan, Marianne Rodriguez, Eva Derman, and Frank Costantini.........          4244 4252
    Editing of Pre-mRNAs Can Occur before cis- and trans-Splicing in Petunia Mito-
         chondria. Claudia A. Sutton, Patricia L. Conklin, Kim D. Pruitt, and
         Maureen R. Hanson.................................................             4274 4277
    RNA Editing Intermediates of cox2 Transcripts in Maize Mitochondria. Austin
         J. Yang and R. Michael Mulligan ......................................         4278-4281

                             CELL GROWTH AND DEVELOPMENT
    Ribosomal Protein Genes Are Overexpressed in Colorectal Cancer: Isolation
        of a cDNA Clone Encoding the Human S3 Ribosomal Protein. Kay
        Pogue-Geile, John R. Geiser, Min Shu, Carla Miller, Ira G. Wool, Arnold
        I. Meisler, and James M. Pipas........................................          3842-3849
    Phosphorylation of Xenopus Cyclins Bi and B2 Is Not Required for Cell Cycle
        Transitions. Tetsuro Izumi and James L. Maller........................          3860-3867
    Maturation and Function of Cystic Fibrosis Transmembrane Conductance Regu-
        lator Variants Bearing Mutations in Putative Nucleotide-Binding Domains 1
        and 2. Richard J. Gregory, Devra P. Rich, Seng H. Cheng, David W.
        Souza, Sucharita Paul, Parthasarathy Manavalan, Matthew P. Anderson,
        Michael J. Welsh, and Alan E. Smith ..................................          3886-3893
    Overexpression of RPII, a Novel Inhibitor of the Yeast Ras-Cyclic AMP Pathway,
        Down-Regulates Normal but Not Mutationally Activated Ras Function.
        Jae-Hong Kim and Scott Powers ......................................            3894-3904

                                                                               Continued on following page
Continued from preceding page

    Isolation and Characterization of Drosophila Multidrug Resistance Gene Ho-
         mologs. C.-Ting Wu, Mark Budding, Mary S. Griffin, and James M.
         Croop ..............................................................             3940-3948
    A Novel Ca2+/Calmodulin-Dependent Protein Kinase and a Male Germ Cell-
         Specific Calmodulin-Binding Protein Are Derived from the Same Gene.
         Anthony R. Means, Francisco Cruzalegui, Brigitte LeMagueresse, David
         S. Needleman, Gayle R. Slaughter, and Tomio Ono .....................            3960-3971
    Protein Truncation Is Required for the Activation of the c-myb Proto-Oncogene.
         Friedrich A. Grasser, Thomas Graf, and Joseph S. Lipsick...............          3987-3996
    Identification of Amino Acid Residues Required for Ras p21 Target Activation.
         Mark S. Marshall, Lenora J. Davis, Robert D. Keys, Scott D. Mosser,
         Wendy S. Hill, Edward M. Scolnick, and Jackson B. Gibbs ..............           3997-4004
    The Proliferative and Morphologic Responses of a Colon Carcinoma Cell Line
        (LIM 1215) Require the Production of Two Autocrine Factors. Andrew M.
        Sizeland and Antony W. Burgess ......................................             4005-4014
    Intrachromosomal Rearrangements Fusing L-myc and rlf in Small-Cell Lung Can-
        cer. Tomi P. Makela, Juha Kere, Robert Winqvist, and Kari Alitalo......           4015-4021
    The Saccharomyces cerevisiae YAK] Gene Encodes a Protein Kinase That Is In-
        duced by Arrest Early in the Cell Cycle. Stephen Garrett, Marisa M.
        Menold, and James R. Broach........................................               4045-4052
    Dominant Inhibitory Ras Mutants Selectively Inhibit the Activity of Either Cellu-
        lar or Oncogenic Ras. Dennis W. Stacey, Larry A. Feig, and Jackson B.
        Gibbs ...............................................................             4053-4064
    Structure and Transforming Potential of the Human cot Oncogene Encoding a
        Putative Protein Kinase. Jun Miyoshi, Takatsugu Higashi, Hiroyuki
        Mukai, Tohru Ohuchi, and Takeo Kakunaga...........................                4088-4096
    The Highly Conserved N-Terminal Domains of Histones H3 and H4 Are Required
        for Normal Cell Cycle Progression. Brian A. Morgan, Barbara A.
        Mittman, and M. Mitchell Smith.......................................             4111-4120
    The AGA] Product Is Involved in Cell Surface Attachment of the Saccharomyces
        cerevisiae Cell Adhesion Glycoprotein a-Agglutinin. Amit Roy, Cha Fen
        Lu, Donna L. Marykwas, Peter N. Lipke, and Janet Kurjan..............             4196-4206
    ElA Induces Phosphorylation of the Retinoblastoma Protein Independently of Di-
        rect Physical Association between the ElA and Retinoblastoma Products.
        Hwei-Gene Heidi Wang, Giulio Draetta, and Elizabeth Moran ............            4253-4265
    Constant Expression and Activity of Protein Phosphatase 2A in Synchronized
        Cells. Ralf Ruediger, Jill E. Van Wart Hood, Marc Mumby, and Gernot
        Walter ..............................................................             4282-4285

                    CELL AND ORGANELLE STRUCTURE AND ASSEMBLY
    Viability of Clathrin Heavy-Chain-Deficient Saccharomyces cerevisiae Is Compro-
         mised by Mutations at Numerous Loci: Implications for the Suppression Hy-
         pothesis. Alan L. Munn, Linda Silveira, Marc Elgort, and Gregory S.
         Payne ..............................................................             3868-3878
    Atypical Mannolipids Characterize Thy-l-Negative Lymphoma Mutants. P.
         Lemansky, D. K. Gupta, S. Meyale, G. Tucker, and A. M. Tartakoff .....           3879-3885
    In Vivo Assembly of Yeast Mitochondrial oa-Ketoglutarate Dehydrogenase Com-
         plex. Barbara Repetto and Alexander Tzagoloff.......................             3931-3939


                                                                                 Continued on following page
Continued from preceding page

    Cloning and Characterization of a Gene Which Determines Osmotic Stability in
        Saccharomyces cerevisiae. Lubomira I. Stateva, Stephen G. Oliver,
        Laurence J. Trueman, and Pencho V. Venkov ..........................          4235-4243
    TRKI and TRK2 Encode Structurally Related K+ Transporters in Saccharomyces
        cerevisiae. Christopher H. Ko and Richard F. Gaber....................        4266-4273

                      DNA DYNAMICS AND CHROMOSOME STRUCTURE
    Chromosome Structure: DNA Nucleotide Sequence Elements of a Subset of the
        Minichromosomes of the Protozoan Trypanosoma brucei. Michael Weiden,
        Yvonne N. Osheim, Ann L. Beyer, and Lex H. T. Van der Ploeg.........          3823-3834
    Mapping of Replication Initiation Sites in Mammalian Genomes by Two-Dimen-
        sional Gel Analysis: Stabilization and Enrichment of Replication Intermedi-
        ates by Isolation on the Nuclear Matrix. P. A. Dijkwel, J. P. Vaughn, and
        J. L. Hamlin ........................................................         3850-3859
    A Novel, Plasmid-Based System for Studying Gene Rearrangements in Mamma-
        lian Cells. Robert S. Krauss and 1. Bernard Weinstein..................       3915-3924
    V(D)J Recombination: Evidence that a Replicative Mechanism Is Not Required.
        Chih-Lin Hsieh, R. Patrick McCloskey, Eric Radany, and Michael R.
          Lieber ..............................................................       3972-3977
    Xeroderma Pigmentosum Complementation Group C Cells Remove Pyrimidine
        Dimers Selectively from the Transcribed Strands of Active Genes. Jaap
        Venema, Anneke van Hoffen, Veronika Karcagi, A. T. Natarajan, Albert
        A. van Zeeland, and Leon H. F. Mullenders..........................           4128-4134

                                             ERRATUM
    SPT5, an Essential Gene Important for Normal Transcription in Saccharomyces
        cerevisiae, Encodes an Acidic Nuclear Protein with a Carboxy-Terminal Re-
        peat. Michele S. Swanson, Elizabeth A. Malone, and Fred Winston......              4286