Treatment Of Panic Disorders With Alprazolam - Patent 4508726 by Patents-95

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United States Patent: 4508726


































 
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	United States Patent 
	4,508,726



 Coleman
 

 
April 2, 1985




 Treatment of panic disorders with alprazolam



Abstract

Therapeutic process for treating panic disorders in humans comprising, the
     systemic administration of a
     1-methyl-6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine
     including the N-oxides and pharmacologically acceptable acid addition
     salts thereof in combination with a pharmaceutical carrier.


 
Inventors: 
 Coleman; James H. (Cumberland, RI) 
 Assignee:


The Upjohn Company
 (Kalamazoo, 
MI)





Appl. No.:
                    
 06/518,332
  
Filed:
                      
  August 1, 1983

 Related U.S. Patent Documents   
 

Application NumberFiling DatePatent NumberIssue Date
 418922Sep., 1982
 

 



  
Current U.S. Class:
  514/220
  
Current International Class: 
  A61K 31/55&nbsp(20060101); A61K 031/41&nbsp()
  
Field of Search: 
  
  
 424/269
  

References Cited  [Referenced By]
U.S. Patent Documents
 
 
 
3987052
October 1976
Hester



   Primary Examiner:  Friedman; Stanley J.


  Attorney, Agent or Firm: Jameson; William G.
Killinger; John J.



Parent Case Text



This application is a continuation of Ser. No. 418,922, filed Sept. 16,
     1982, now abandoned.

Claims  

I claim:

1.  A process for preventing or treating panic attacks comprising the administration to a human subject susceptible to panic attacks, in unit dosage form, from about 0.01 mg to about 0.4
mg/kg body weight of 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine or the pharmacologically acceptable acid addition salt or a (5) N-oxide thereof in association with a pharmaceutical carrier.


2.  The process of claim 1 wherein the 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is in the form of the (5) N-oxide.


3.  The process of claim 1 wherein the 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is in the form of the free base.  Description  

BRIEF SUMMARY OF THE INVENTION


This invention is a prophylatic or therapeutic process for treating panic disorders in humans comprising the systemic administration of a benzodiazepine of the Formula 1: ##STR1## and including the N-oxides and pharmacologically acceptable acid
addition salts thereof in combination with a pharmaceutical carrier.


BACKGROUND OF THE INVENTION


Panic attacks, a spontaneous attack, thought to be a biochemical disorder of genetic origin, begins in the majority of subjects at ages 15 to 30 years.  The attacks occur with no apparent reason to the subject and are accompanied by symptoms of
hyperventilation, heart-pounding, pain in head, numbness or tingling of the limbs, hot and cold flashes, lump in throat, and the like.  The attacks continue to occur and can lead the subject to become house bound.


Various treatments have been prescribed, including hypnosis and behavior therapies and chemotherapy, particulary the administration of imipramine hydrochloride or phenalzine sulfate.  The latter although somewhat effective have undesirable
side-effects, chlordiazepoxide and diazepam have been tried but found not effective to block the panic attack.


Alprazolam has been indicated for the management of anxiety disorders.


DETAILED DESCRIPTION


The compounds of the Formula I can be prepared by methods disclosed in U.S.  Pat.  No. 3,987,052, issued Oct.  19, 1976 and as disclosed hereafter.


The oxidation of a compound of the Formula I normally follows a 2-step process with the formation of an oxazirino structure.


The (5) N-oxides of a compound of the Formula I can also be made by reacting a 2-methoxy-5-phenyl-7-chloro-3H-1,4-benzodiazepine 4-oxide with acethydrazide.  This reaction can be carried out in a solvent inert to the reaction such as a lower
alkanol of boiling range of about 100.degree.  C. or above, especially 1-butanol or 1-pentanol.  It is convenient to reflux the reaction mixture, and a convenient reaction temperature is in the range of 100.degree.-140.degree.  C. Under these conditions,
the reaction time will be from 12 to 48 hours.


The peracid oxidation method described above for producing the (5) N-oxides of a compound of the Formula I produces an intermediate oxazirino compound as described above, and this latter compound can be further rearranged to the desired (5)
N-oxide by heating in an appropriate solvent inert to the reaction and capable of being sustained in liquid form at normal pressure at temperatures of 150.degree.-200.degree.  C. Suitable reaction solvents are the liquid paraffinic hydrocarbons of 10-18
carbon atoms or other solvent hydrocarbons boiling above about 150.degree.  C. such as mesitylene.  The reaction is conveniently carried out under reflux for 10 minutes to 1 hour.


Acid addition salts of compounds of the Formula I can be prepared by neutralization of the free base with the appropriate amount of an inorganic or organic acid, examples of which are hydrochloric, hydrobromic, sulfuric, nitric, phosphoric,
acetic, lactic, benzoic, salicyclic, glycolic, succinic, tartaric, maleic, malic, pamoic, cyclohexanesulfamic, citric and methanesulfonic acids, and like acids.  The neutralization can be carried out by a variety of procedures known to the art to be
generally useful for the preparation of amine acid addition salts.  The choice of the most suitable procedure will depend on a variety of factors including convenience of operation, economic consideration, and particularly the solubility characteristics
of the particular free base, the acid, and the acid addition salt.  If the acid is soluble in water, the free base can be dissolved in water containing an equivalent amount of the acid, and thereafter, the water can be removed by evaporation; in some
instances, the salt precipitates from the aqueous solution, particularly when cooled, and evaporation is not necessary.  If the acid is soluble in a relatively nonpolar solvent, for example, diethyl ether or diisopropyl ether, separate solutions of acid
and free base in such a solvent can be mixed in equivalent amounts, whereupon the acid addition salt will usually precipitate because of its relatively low solubility in the nonpolar solvent.  Alternatively, the free base can be mixed with an equivalent
amount of the acid in the presence of a solvent of moderate polarity, for example, a lower alkanol, a lower alkanone, or a loweralkyl ester of a lower alkanoic acid.  Examples of these solvents are ethanol, acetone, and ethyl acetate, respectively. 
Subsequent admixture of the resulting solution of acid addition salt with a solvent of relatively low polarity, for example, diethyl ether or hexane, will usually cause precipitation of the acid addition salt.  These acid addition salts are useful for
upgrading the free bases.


The compositions of the present invention are presented for administration to humans in unit dosage forms, such as tablets, capsules, pills, powders, granules, sterile parenteral solutions or suspensions, and oral solutions or suspensions, and
oil in water and water in oil emulsions containing suitable quantities of the compound of Formula I.


For oral administration either solid or fluid unit dosage forms can be prepared.  For preparing solid compositions such as tablets, the compound of Formula I is mixed with conventional ingredients such as talc, magnesium stearate, dicalcium
phosphate, magnesium aluminum silicate, calcium sulfate, starch, lactose, acacia, methylcellulose, and functionally similar materials as pharmaceutical diluents or carriers.  Wafers are prepared in the same manner as tablets, differing only in shape and
the inclusion of sucrose or other sweetener and flavor.  In their simplest embodiment, capsules, like tablets, are prepared by mixing the compound with an inert pharmaceutical diluent and filling the mixture into a hard gelatin capsule of appropriate
size.  Soft gelatin capsules are parpared by machine encapsulation of a slurry of the compound with an acceptable vegetable oil, light liquid petrolatum or other inert oil.


Fluid unit dosage forms for oral administration such as syrups, elixirs, and suspensions can be prepared.  The water-soluble forms can be dissolved in an aqueous vehicle together with sugar, aromatic flavoring agents and preservatives to form a
syrup.  An elixir is prepared by using a hydro-alcoholic (ethanol) vehicle with suitable sweeteners such as sugar and saccharin, together with an aromatic flavoring agent.


Suspensions can be prepared with a syrup vehicle with the aid of a suspending agent such as acacia, tragacanth, methylcellulose and the like.


For parenteral administration, fluid unit dosage forms are prepared utilizing the compound and a sterile vehicle, water being preferred.  The compound, depending on the vehicle and concentration used, can be either suspended or dissolved in the
vehicle.  In preparing solutions the compound can be dissolved in water for injection and filter sterilized before filling into a suitable vial or ampul and sealing.  Advantageously, adjuvants such as a local anesthetic, preservative and buffering agents
can be dissolved in the vehicle.  To enhance the stability, the composition can be frozen after filling into the vial and the water removed under vacuum.  The dry lyophilized powder is then sealed in the vial and an accompanying vial of water for
injection is supplied to reconstitute the liquid prior to use.  Parenteral suspensions are prepared in substantially the same manner except that the compound is suspended in the vehicle instead of being dissolved and sterilization cannot be accomplished
by filtration.  The compound can be sterilized by exposure to ethylene oxide before suspending in the sterile vehicle.  Advantageously, a surfactant or wetting agent is included in the composition to facilitate uniform distribution of the compound.


The term unit dosage form as used in the specification and claims refers to physically discrete units suitable as unitary dosages for human subjects and animals, each unit containing a predetermined quantity of a active material calculated to
prevent panic attacks or treat panic disorders in association with the required pharmaceutical diluent, carrier or vehicle.  The specifications for the novel unit dosage forms of this invention are dictated by and directly dependent on (a) the unique
characteristics of the active material and the particular effect to be achieved, and (b) the limitations inherent in the art of compounding such an active material for use in humans and animals, as disclosed in detail in this specification, these being
features of the present invention.  Examples of suitable unit dosage forms in accord with this invention are tablets, capsules, pills, suppositories, powder packets, granules, wafers, cachets, teaspoonfuls, tablespoonfuls, dropperfuls, ampuls, vials,
segregated multiples of any of the foregoing, and other forms as herein described.


The dosage of the compound for treatment depends on route of administration; the age, weight, and condition of the patient.  A dosage schedule of from about 1 to 10 mg/day in a single or divided dose, embraces the effective range for treating
panic disorders for which the compositions are effective.  The dosage to be administered is calculated on the basis of from about 0.01 to about 0.4 mg/kg by weight of subject per day.


The compound is compounded with a suitable pharmaceutical carrier in unit dosage form for convenient and effective administration.  In the preferred embodiments of this invention, the dosage units contain the compound in: 0.1, 0.5, 1 and 10 mg
amount for systemic treatment; and 0.1% to 1% w/v for parenteral treatment.


The compositions are useful in preventing and treating panic attacks in adults (age fifteen years or more), agaraphobia, and phobic anxiety. 

The following examples are illustrative of the best mode contemplated by the inventor for
carrying out his invention and are not to be construed as limiting.


EXAMPLE 1


A lot of 10,000 tablets, each containing 0.5 mg of 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is prepared from the following types and amounts of ingredients:


______________________________________ 8-Chloro-1-methyl-6-phenyl-4H--s-triazolo-  1 Gm  [4,3-a][1,4]benzodiazepine  Dicalcium phosphate 1,500 Gm  Methylcellulose, U.S.P. (15 cps.)  60 Gm  Talc 150 Gm  Corn Starch 200 Gm  Calcium stearate 12 Gm 
______________________________________


The compound and dicalcium phosphate are mixed well, granulated with 7.5 percent solution of methylcellulose in water, passed through a No. 8 screen and dried carefully.  The dried granules are passed through a No. 12 screen, mixed thoroughly
with the talc, starch and stearate, and compressed into tablets.


These tablets are useful in preventing panic attcks at a dose of 1 tablet 4 times a day.


EXAMPLE 2


One thousand two-piece hard gelatin capsules, each containing 0.5 mg of 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine are prepared from the following types and amounts of ingredients:


______________________________________ 8-Chloro-1-methyl-6-phenyl-4H--s-triazolo  0.5 Gm  [4,3-a][1,4]benzodiazepine  Talc 25 Gm  Magnesium stearate 250 Gm  ______________________________________


The ingredients are mixed well and filled into capsules of the proper size.


Capsules so prepared are useful to prevent panic attacks at a dose of one capsule four times a day.


EXAMPLE 3


One thousand tablets for sublinqual use are prepared from the following ingredients:


______________________________________ 8-Chloro-1-methyl-6-phenyl-4H--s-triazolo  1 Gm  [4,3-a][1,4]benzodiazepine  Polyethylene glycol 4,000, powdered  150 Gm  Polyethylene glycol 6,000, powdered  75 Gm  ______________________________________


The ingredients are mixed well and compressed into sublingual-type tablets weighing 226 mg.


These tablets placed under the tongue are useful in treating panic attacks at a dose of 1 tablet.


EXAMPLE 4


Soft gelatin capsules for oral use, each containing 10 mg of 1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine are prepared by first dispersing the micronized compound in corn oil to render the material capsulatable and then encapsulating
in the usual manner.


One capsule taken daily is useful to prevent panic attacks.


EXAMPLE 5


One thousand tablets, each containing 5 mg.  of 8-chloro-1-methyl-6phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine are made from the following types and amounts of ingredients:


______________________________________ 8-Chloro-1-methyl-6-phenyl-4H--s-triazolo  5 Gm  [4,3-a][1,4]benzodiazepine  Lactose 355 Gm  Microcrystalline cellulose NF  120 Gm  Starch 16 Gm  Magnesium stearate powder 4 Gm 
______________________________________


The ingredients are screened and blended together and pressed into 500 mg tablets.


The tablets are useful to prevent panic attacks at a dose of one tablet twice a day.


EXAMPLE 6


A sterile preparation suitable for intramuscular injection and containing 1 mg of 8-chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine in each milliliter is prepared from the following ingredients:


______________________________________ 8-Chloro-1-methyl-6-phenyl-4H--s-triazolo  1 Gm  [4,3-a][1,4]benzodiazepine  Benzyl benzoate 200 ml  Methylparaben 1.5 Gm  Propylparaben 0.5 Gm  Cottonseed oil, q.s. 1,000 ml 
______________________________________


One milliliter of this sterile preparation is injected to treat panic attack.


EXAMPLE 7


Following the procedure of the preceding Example 1 to 6, inclusive, compositions are similarly prepared and administered substituting one equal amount of the N-oxide or hydrochloride salt of the active compound of the example.


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