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Treatment Of Panic Disorders With Alprazolam - Patent 4508726


BRIEF SUMMARY OF THE INVENTIONThis invention is a prophylatic or therapeutic process for treating panic disorders in humans comprising the systemic administration of a benzodiazepine of the Formula 1: ##STR1## and including the N-oxides and pharmacologically acceptable acidaddition salts thereof in combination with a pharmaceutical carrier.BACKGROUND OF THE INVENTIONPanic attacks, a spontaneous attack, thought to be a biochemical disorder of genetic origin, begins in the majority of subjects at ages 15 to 30 years. The attacks occur with no apparent reason to the subject and are accompanied by symptoms ofhyperventilation, heart-pounding, pain in head, numbness or tingling of the limbs, hot and cold flashes, lump in throat, and the like. The attacks continue to occur and can lead the subject to become house bound.Various treatments have been prescribed, including hypnosis and behavior therapies and chemotherapy, particulary the administration of imipramine hydrochloride or phenalzine sulfate. The latter although somewhat effective have undesirableside-effects, chlordiazepoxide and diazepam have been tried but found not effective to block the panic attack.Alprazolam has been indicated for the management of anxiety disorders.DETAILED DESCRIPTIONThe compounds of the Formula I can be prepared by methods disclosed in U.S. Pat. No. 3,987,052, issued Oct. 19, 1976 and as disclosed hereafter.The oxidation of a compound of the Formula I normally follows a 2-step process with the formation of an oxazirino structure.The (5) N-oxides of a compound of the Formula I can also be made by reacting a 2-methoxy-5-phenyl-7-chloro-3H-1,4-benzodiazepine 4-oxide with acethydrazide. This reaction can be carried out in a solvent inert to the reaction such as a loweralkanol of boiling range of about C. or above, especially 1-butanol or 1-pentanol. It is convenient to reflux the reaction mixture, and a convenient reaction temperature is in the range of

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