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PUBH5208 SCREENING AND DIAGNOSTIC TEST EVALUATION

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					        PUBH5208 Screening and Diagnostic Test Evaluation
                                                Elective
Credit points: 2                                     Semester: 2a (9)
Delivery mode: On-line (1x2hr seminar or 2hr of online discussion per week for 7
weeks)
Pre-requisites: PUBH5010                             Co-requisites: N/A
Epidemiology Methods and Uses

Unit coordinator: tbc, School of Public Health
    Summary

This unit is designed to develop concepts introduced in Epidemiology Methods and
Uses and to provide more detail for students interested in screening and diagnostic
tests. It will include examples of tests used in clinical medicine, public health and
other areas of health care practice. At the end of this unit, participants should be able
to: (i) use information from articles evaluating screening and diagnostic tests in order
to apply test results to individual patients; (ii) consider the internal validity of studies
used to assess diagnostic and screening tests; and (iii) identify and appraise
systematic reviews covering screening and diagnostic tests. The unit is based on
weekly discussion of material provided in course workbook, session outlines and pre-
reading. Students will be encouraged to contribute examples for discussion. This unit
is offered in online/distance mode only.
Aim

To develop understanding of concepts related to the evaluation of screening and
diagnostic tests

Learning objectives

At the end of this unit students will be able to:

o    Understand the concepts of sensitivity, specificity, repeatability and predictive
     values.
o    Calculate sensitivity, specificity, prevalence and predictive values.
o    Calculate and apply Likelihood Ratios
o    Calculate and apply Likelihood Ratios with more than two outcome values
o    Understand ROC curves
o    Understand the concepts and importance of the following issues when
     conducting a critical appraisal of a screening or diagnostic test:
     o Independent, blind reference standard
     o Spectrum of patients
     o Verification bias
o    Understand the concepts and importance of the following issues when
     conducting a critical appraisal of a systematic review for a screening or diagnostic
     test:
     o Inclusion/exclusion criteria
     o Publication bias
     o Implicit / explicit thresholds
     o Applicability of screening / diagnostic accuracy assessments to other settings




School of Public Health, University of Sydney                              updated on: 11/08/09
Content

o    revisiting sensitivity and specificity;
o    positive and negative predictive values;
o    use of likelihood ratios and application of test results to individual patients;
o    assessing the validity of a study evaluating the accuracy of a test;
o    Assessing the validity of a systematic review of a diagnostic or screening test.

Instructional format

The unit is entirely web-based, with tutorials being held using asynchronous
discussion of material provided in the course and using pre-reading. Discussions
require approximately an additional two hours reading/preparation each week.

Face-to-face tutorials may also be offered.

It is recommended that students are on-line for either 20-30 min, five days/week for
six weeks.

Assessment

1x1000 word critical appraisal - 30%

1x1500 word final assignment - 70%

Learning materials

Textbooks
Course notes are provided.

Notes and readings will be supplied on-line and as the unit workbook. These will be
used to assist students preparing for each week of the unit.


Notes

Evaluation:
On-line evaluation questionnaire of course materials, content, presentation and
assessment will be undertaken by the participants.




School of Public Health, University of Sydney                            updated on: 11/08/09

				
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Description: PUBH5208 SCREENING AND DIAGNOSTIC TEST EVALUATION