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Wednesday, April 1, 2008, 16:30 Room A100 Sciences II Molecular recognition of lanthanide(III) ion complexes. Contrast optimization in magnetic resonance imaging Prof. Pascal H. Fries Laboratoire de Reconnaissance Ionique et Chimie de Coordination, CEA 38054 Grenoble, France, France Trivalent lanthanide Ln(III) ions have the same chemistry, but different magnetic effects on the neighbouring molecules, leading to a rich variety of structural and dynamic information on this environment. Taking advantage of this unique property for a series of elements of the periodic table, we use nuclear magnetic resonance (NMR) to explore how a Ln(III) complex in solution attracts, repels, captures, and releases a charged or neutral substract molecule bearing the observed nuclear spins. We study how this relative motion depends on the molecular properties of the complex. The obtained information aims at being benchmark data that help to validate the theories describing the dynamics of representative simple species involved in molecular recognition, an important concept of biology and chemistry. Besides, the relative motion of the water molecules with respect to a complex of the lanthanide gadolinium (III) determines the contrast efficiency of this complex in magnetic resonance imaging MRI. Useful concepts for the rational design of high- performance contrast agents are presented.
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