Wednesday April 1 2008 16 30 Room A100 Sciences II Molecular recognition of lanthanide III ion complexes Contrast optimi by psg89925


									                           Wednesday, April 1, 2008, 16:30
                              Room A100 Sciences II

    Molecular recognition of lanthanide(III) ion complexes.
     Contrast optimization in magnetic resonance imaging

                                  Prof. Pascal H. Fries
          Laboratoire de Reconnaissance Ionique et Chimie de Coordination, CEA
                             38054 Grenoble, France, France

Trivalent lanthanide Ln(III) ions have the same chemistry, but different magnetic effects on the
neighbouring molecules, leading to a rich variety of structural and dynamic information on this
environment. Taking advantage of this unique property for a series of elements of the periodic
table, we use nuclear magnetic resonance (NMR) to explore how a Ln(III) complex in solution
attracts, repels, captures, and releases a charged or neutral substract molecule bearing the observed
nuclear spins. We study how this relative motion depends on the molecular properties of the
complex. The obtained information aims at being benchmark data that help to validate the theories
describing the dynamics of representative simple species involved in molecular recognition, an
important concept of biology and chemistry. Besides, the relative motion of the water molecules
with respect to a complex of the lanthanide gadolinium (III) determines the contrast efficiency of
this complex in magnetic resonance imaging MRI. Useful concepts for the rational design of high-
performance contrast agents are presented.

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