Reference by lifemate

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									CARDIAC REHABILITATION


Study          Design   No. of           Patient       Interventions               Outcomes                                   Subgroup Analyses of        Notes
                        Patients         Population                                                                           Clinical Endpoints in
                                                                                                                              Women

Belardinelli   RCT      N overall: 118   Secondary     1) Bike riding 30 minutes   Primary study outcome(s):                  None reported
2001                                     prevention    3x/week for 6 months (n     Functional capacity, QOL, restenosis
                        N women: 19                    = 59)                       rates, CV outcomes
                                         Status Post
                        Mean age: 57     PTCA          2) No exercise (n = 59)     Clinical endpoints of interest:
                                                                                   Composite outcome(s): significant
                        Age range: 42-                                             Cardiac deaths, PTCA, MI, CABG 
                        69                                                         RR for exercise 0.71 (0.60-0.91) p 0.008

                        % Diabetics:                                               2) Heart attack/MI: not significant
                        rehab 17%                                                  Rehab 1.7% control 5.1% RR 1.05
                        control 20%                                                (0.68, 1.59) p 0.31

                        % Caucasian                                                3) Stroke (hemorrhagic, non-
                        NR                                                         hemorrhagic, TIA): NR

                                                                                   4) Revascularization procedure (PCI,
                                                                                   bypass): not significant
                                                                                   PTCA: rehab 6.8%, control 18.6% RR
                                                                                   0.84 (0.76-1.05) p = 0.19
                                                                                   CABG: rehab 3.4%, control 8.5% RR
                                                                                   0.99 (0.76-1.46) p = 0.26

                                                                                   5) Death/mortality: 0

                                                                                   6) CHF: NR


Carson 1982    RCT      N overall: 303   Secondary     1) Supervised exercise      Primary study outcome(s):                  Not applicable (no women)   When
                                         prevention    2x/week x 12 weeks (n =     Total mortality at 3 month f/u                                         broken
                        N women:                       151)                                                                                               down by
                        0                Status post                               Clinical endpoints of interest:                                        location of
                                         MI            2) Usual care (n = 152)     1) Composite outcome(s): NR                                            MI, subjects
                        Mean age:                                                                                                                         with inferior
                        Exer 50.3                                                  2) Heart attack/MI: NR                                                 MI
                        Control 52.8                                                                                                                      appeared to
                                                                                   3) Stroke (hemorrhagic, non-                                           have



                                                                            Page 1 of 16
Study     Design   No. of           Patient       Interventions                Outcomes                                   Subgroup Analyses of    Notes
                   Patients         Population                                                                            Clinical Endpoints in
                                                                                                                          Women
                   Age range:                                                  hemorrhagic, TIA): NR                                              significant
                   70                                                                                                                            reduction in
                                                                               4) Revascularization procedure (PCI,                               mortality
                   % Diabetics:                                                bypass): NR                                                        with
                   NR                                                                                                                             exercise
                                                                               5) Death/mortality:                                                compared
                   % Caucasian:                                                Total Mortality: intention to treat                                to controls.
                   NR                                                          Exercise     12/151 8%
                                                                               Control 21/152 14%                                                 Dropout
                                                                               P = NS                                                             31% in
                                                                                                                                                  exercise
                                                                               Total Mortality: for those who completed                           arm
                                                                               exercise program period
                                                                               Exercise     7/104 8%
                                                                               Control 15/135 11%
                                                                               P = NS

                                                                               6) CHF: NR


Dugmore   RCT      N overall: 124   Secondary     1) Calisthenics & aerobic    Primary study outcome(s):                  None reported           Stratified
1999                                prevention    training (bike, walk, jog,   VO2, psychological wellbeing, QOL &                                into good or
                   N women:                       calisthenics) 3x/week x      vocational status post-MI                                          poor
                   2                Status post   1year (n = 62)                                                                                  prognosis,
                                    MI                                         Clinical endpoints of interest:                                    then
                   Mean age:                      2) Usual care (n = 62)       1) Composite outcome(s): NR                                        randomized
                   Good
                   prognosis                                                   2) Heart attack/MI:
                   subgroup:                                                   Exercise 5
                   51.6-52                                                     Control 14
                    Poor                                                       p < 0.05
                   prognosis
                   subgroup:                                                   3) Stroke (hemorrhagic, non-
                   59.3-59.5                                                   hemorrhagic, TIA): NR

                   Age range: NR                                               4) Revascularization procedure (PCI,
                                                                               bypass): NR
                   % Diabetics:
                   NR                                                          5) Death/mortality:
                                                                               Exercise 2
                   % Caucasian:                                                Control 3
                   NR                                                          P = NS



                                                                        Page 2 of 16
Study          Design   No. of           Patient       Interventions                 Outcomes                                  Subgroup Analyses of        Notes
                        Patients         Population                                                                            Clinical Endpoints in
                                                                                                                               Women

                                                                                     6) CHF: NR



Fridlund       RCT      N overall: 116   Secondary     1) Multidisciplinary CR for   Primary study outcome(s):                 None reported
1992                                     prevention    1hr weekly (including         Fitness level, HRQoL, cardiac events at
                        N women: 15                    30min exercise) x 6           6 & 12 months post-MI
                                         Status post   months (n = 53)
                        Mean age:        MI                                          Clinical endpoints of interest:
                        Rehab 55                       2) Usual care (n = 63)        1) Composite outcome(s): NR
                        Control 57.6
                                                                                     2) Heart attack/MI:
                        Age range:                                                         Rehab: 7.5%
                        36-65                                                              Control: 23% p 0.024

                        % Diabetics:                                                 3) Stroke (hemorrhagic, non-
                        Rehab: 9.4%                                                  hemorrhagic, TIA): NR
                        Control 9.5%
                                                                                     4) Revascularization procedure (PCI,
                        % Caucasian                                                  bypass):
                        NR                                                                 Rehab: 15.1%
                                                                                           Control: 16.4% NS

                                                                                     5) Death/mortality:
                                                                                         Rehab: 1.9%
                                                                                         Control: 4.9% NS

                                                                                     6) CHF: NR


Hakkila 1976   RCT      N overall: 350   Secondary     1) Rehab including            Primary study outcome(s): Cardiac         Not applicable (no women)   Study
                                         prevention    exercise 2x/week and          morbidity & mortality at 2yr f/u                                      consists of
                        N women:                       counseling (n = 172)                                                                                3 series of
                        0                Status post                                 Clinical endpoints of interest:                                       studies with
                                         MI            2) Usual care (n = 178)       1) Composite outcome(s): NR                                           small
                        Mean age: NR                                                                                                                       numbers.
                                                       Report of 3 individual        2) Heart attack/MI: difference between                                Unclear if
                        Age range:                     series                        cardiac morbidity between rehab and                                   patients
                        <65                                                          usual care group was not significant.                                 overlap.
                                                                                     Rehab n = 11                                                          Based on




                                                                                Page 3 of 16
Study        Design   No. of           Patient      Interventions                  Outcomes                                   Subgroup Analyses of            Notes
                      Patients         Population                                                                             Clinical Endpoints in
                                                                                                                              Women
                      % Diabetics:                                                 Control n = 7, p = NS                                                      confusing
                      NR                                                                                                                                      methodo-
                                                                                   3) Stroke (hemorrhagic, non-                                               logy & low
                      % Caucasian:                                                 hemorrhagic, TIA): NR                                                      number
                      NR                                                                                                                                      would
                                                                                   4) Revascularization procedure (PCI,                                       probably
                                                                                   bypass): NR                                                                exclude

                                                                                   5) Death/mortality: differences were not
                                                                                   significant
                                                                                   Rehab n =11
                                                                                   Control n = 17, p = NS

                                                                                   6) CHF: NR


Hamalainen   RCT      N overall: 375   Secondary    1) Multi-factorial lifestyle   Primary study outcome(s):                  No significant differences in   No
1995                                   prevention   program: optimal medical       All cause mortality at 15 years.           total mortality men vs.         organized
                      N women:                      care, physical activity                                                   women. Numbers not              intervention
                      74               Post MI      (cycle ergometry),             Clinical endpoints of interest:            reported.                       between yr
                                       patients     smoking cessation &            1) Composite outcome(s):                                                   3-15
                      Mean age:                     dietary counseling,            All cause mortality
                      53.0 -58.4                    psychosocial advice.           CR 64.4%, control 66.8%, p = NS
                                                    Intensive contact x 3
                      Age range:                    months than sporadic for       2) Heart attack/MI: NR
                      < 65                          33 months (3yr total) (n =
                                                    188)                           3) Stroke (hemorrhagic, non-
                      % Diabetics:                                                 hemorrhagic, TIA): NR
                      9.8 interven-                 2) Usual care (n = 187)
                      tion, 6.4                                                    4) Revascularization procedure (PCI,
                      control                                                      bypass): NR

                      % Caucasian:                                                 4) Death/mortality:
                      NR                                                           Coronary:
                                                                                   CR 47.9%, control 58.8% p = 0.004
                                                                                   Sudden death
                                                                                   CR 16.5% control 28.9% p = 0.006
                                                                                   Non-coronary
                                                                                   CR 16.5% control 8.0% P = 0.004

                                                                                   6) CHF: OR 2.0 (1.16-3.44) p < 0.05




                                                                           Page 4 of 16
Study          Design   No. of           Patient      Interventions                  Outcomes                                 Subgroup Analyses of    Notes
                        Patients         Population                                                                           Clinical Endpoints in
                                                                                                                              Women




Haskell 1994   Cohort   N overall: 300   Secondary    1) Multifactor risk            Primary study outcome(s):                None reported           Intervention
               study                     prevention   reduction program: Over        Change in coronary stenoses on repeat                            group with
                        N women: 41                   4 years attended regular       angiogram at 4years by quantitative                              significant
SCRIP                                    Coronary     clinic visits for counseling   coronary angiography and cardiac                                 improve-
                        Mean age:        artery       on strategies to decrease      events                                                           ments in
                        56               disease      CRFs—included exercise                                                                          total
                                                      counseling (n = 145)           Clinical endpoints of interest:                                  cholesterol,
                        Age range:                                                   1) Composite outcome(s):                                         LDL, HDL,
                        NR                            2) Usual care (n = 155)        Cardiac events (death, MI CABG, PTCA)                            TGs,
                                                                                     initiating hospitalization                                       weight,
                        % Diabetics:                  Patients stratified by site    Intervention RR 0.61 (0.4-0.9) p 0.05                            exercise
                        <75                           and type of intervention       Usual care RR 1.0 (referent)                                     capacity
                                                      after cardiac cath (none,                                                                       compared
                        % Caucasian:                  PTCA, CABG)                    2) Heart attack/MI:                                              to usual
                        NR                                                           Intervention RR 0.61 (0.4-0.9) p 0.05                            care group.
                                                                                     Usual care RR 1.0 (referent)                                     Also
                                                                                                                                                      intervention
                                                                                     3) Stroke (hemorrhagic, non-                                     group with
                                                                                     hemorrhagic, TIA): NR                                            significant
                                                                                                                                                      reduction in
                                                                                     4) Revascularization procedure (PCI,                             progression
                                                                                     bypass):                                                         of CAD by
                                                                                     Intervention 19/119                                              cath.
                                                                                     Usual care 31/127 RRs not given

                                                                                     5) Death/mortality:
                                                                                     Cardiac or sudden death:
                                                                                     Intervention 2/119
                                                                                     Usual care 3/127

                                                                                     6) CHF: NR


Kallio 1979    RCT      N overall: 375   Secondary    1) Lifestyle counseling        Primary study outcome(s):                None reported
                                         prevention   and exercise prescription      Coronary mortality & sudden death over




                                                                             Page 5 of 16
Study         Design   No. of           Patient       Interventions               Outcomes                                     Subgroup Analyses of    Notes
                       Patients         Population                                                                             Clinical Endpoints in
                                                                                                                               Women
                       N women:                       (details unclear)           3yr f/u
                       74               Status post   intensively for 3 months
                                        MI            then more sporadically (n   Clinical endpoints of interest:
                       Mean age: NR                   = 188)
                                                                                  1) Composite outcome: NR
                       Age range:                     2) Usual care (n = 187)
                       <65                                                        2) Nonfatal MI
                                                                                      Rehab      34/188 (18%)
                       % Diabetics:                                                   Usual care 21/187 (11%) p <0.10
                       Interv 9.8%
                       Control 6.4%                                               3) Stroke (hemorrhagic, non-
                                                                                  hemorrhagic, TIA): NR
                       % Caucasian:
                       NR                                                         4) Revascularization procedure (PCI,
                                                                                  bypass): NR

                                                                                  5) Death/mortality:
                                                                                  Total mortality
                                                                                   Rehab 41/188 21.8%
                                                                                   Control 56/187 29.9% p<0.10

                                                                                  CHD mortality
                                                                                   Rehab 35/188 18.6%
                                                                                   Control 55/187 29.4% p = 0.02

                                                                                  Sudden death
                                                                                   Rehab 11/188 5.8%
                                                                                   Control 27/187 14.4% p<0.01

                                                                                  6) CHF: NR


Lidell 1996   RCT      N overall: 116   Secondary     1) Multidisciplinary        Primary study outcome(s):                    None reported           Unclear
                                        prevention    cardiac rehab weekly        Cardiac events, physical/psychological                               whether
                       N women: 15                    (including 1 hr of          conditions, life habits and cardiac health                           everyone
                                        Status post   exercise) x 6 months (n =   knowledge 1 & 5 yrs after MI.                                        accounted
                       Mean age:        MI            53)                                                                                              for at follow-
                       Exercise 55.0                                              Clinical endpoints of interest:                                      up
                       Control 57.6                   2) usual care (n = 63)      1) Composite outcome(s): NR

                       Age range:                                                 2) Heart attack/MI:
                       <65                                                             1year Rehab 7.5%



                                                                           Page 6 of 16
Study        Design   No. of           Patient       Interventions              Outcomes                                 Subgroup Analyses of    Notes
                      Patients         Population                                                                        Clinical Endpoints in
                                                                                                                         Women
                                                                                               Control 23.0% p 0.024
                      % Diabetics:                                                      5 yr   Rehab 21.6%
                      Rehab 9.4                                                                Control 28.8% NS p
                      Control 9.5                                               0.782

                      % Caucasian:                                              3) Stroke (hemorrhagic, non-
                      NR                                                        hemorrhagic, TIA): NR

                                                                                4) Revascularization procedure (PCI,
                                                                                bypass):
                                                                                     1 yr Rehab 15.1%
                                                                                          Control 16.4 NS 0.712
                                                                                     5 yr CABG
                                                                                            Rehab 30.0%
                                                                                            Control 28.8% NS 0.189
                                                                                     5yr PTCA
                                                                                            Rehab 10.0%%
                                                                                            Control 5.8% NS 0.326

                                                                                5) Death/mortality:
                                                                                     All-cause
                                                                                       1yr Rehab 1.9%
                                                                                             Control 4.9% NS 0.310
                                                                                       5 yr Rehab 14.0%
                                                                                             Control 23.1% NS 0.281

                                                                                6) CHF: NR


Marra 1985   RCT      N overall: 167   Secondary     1) Supervised              Primary study outcome(s):                None reported           RRs not
                                       prevention    calisthenics & 25 min      Lipids, work capacity. Cardiac double                            reported
                      N women: NR                    cycling 4x/week for 8-9    product, cardiac deaths. MI, USA, CABG
                                       Status post   weeks (30 sessions) (n =   after 55 months f/u                                              Analysis
                      Mean age:        MI            81)                                                                                         based on
                      Rehab: 49.1                                               Clinical endpoints of interest:                                  161
                      Control: 50.1                  2) Usual care with         1) Composite outcome(s): NR                                      subjects
                                                     recommendation for
                      Age range: 25-                 home exercise (n = 80)     2) Heart attack/MI:
                      65y                                                            Rehab 5/81 (6.1%)
                                                                                     Control 9/80 (11.2%)
                      % Diabetics:
                      Rehab: 7.4%                                               3) Stroke (hemorrhagic, non-



                                                                         Page 7 of 16
Study      Design   No. of           Patient       Interventions              Outcomes                                    Subgroup Analyses of    Notes
                    Patients         Population                                                                           Clinical Endpoints in
                                                                                                                          Women
                    Control 15%                                               hemorrhagic, TIA): NR

                    % Caucasian                                               4) Revascularization procedure (PCI,
                    NR                                                        bypass):
                                                                                   CABG: Rehab 7/81 (8.6%)
                                                                                          Control 9/80 (11.2%)

                                                                              5) Death/mortality:
                                                                                   Total death: Rehab 6/81 (7.4%)
                                                                                                 Control 5/80 (6.3%)
                                                                                  Cardiac death: Rehab 5/81 (6.1%)
                                                                                                  Control 4/80 (5%)

                                                                              6) CHF: NR


Naughton   RCT      N overall: 651   Secondary     1) Supervised exercise     Primary study outcome(s):                   None reported
2000                                 prevention    1hr 3x/week x 3 years (n   Mortality, morbidity, CRFs, psychosocial
                    N women:                       = 323)                     status, exercise tolerance, compliance
                    0                Status post                              with exercise at 3 years and mortality at
                                     MI            2) Usual care (n = 328)    19 years f/u
                    Mean age:
                    Rehab 51.5                                                Clinical endpoints of interest:
                    Control 52.1                                              1) Composite outcome(s): NR

                    Age range: 35-                                            2) Heart attack/MI (fatal & non-fatal):
                    64                                                            3 years: Rehab 17/315 (5.3%)
                                                                                            Control 23/319 (7.0%)
                    % Diabetics:                                              NS
                    NR
                                                                              3) Stroke (hemorrhagic, non-
                    % Caucasian:                                              hemorrhagic, TIA): NR
                    NR
                                                                              4) Revascularization procedure (PCI,
                                                                              bypass):
                                                                                  No diff in CABG (rates NR)

                                                                              5) Death/mortality:
                                                                                    3yr:
                                                                                       All-cause: RR rehab 0.69
                                                                              (0.39-1.25)
                                                                                         NS



                                                                        Page 8 of 16
Study         Design   No. of          Patient         Interventions             Outcomes                                   Subgroup Analyses of    Notes
                       Patients        Population                                                                           Clinical Endpoints in
                                                                                                                            Women
                                                                                          CV deaths: RR rehab 0.73
                                                                                 (0.37-1.43)
                                                                                           NS

                                                                                      19yr
                                                                                          All-cause: RR rehab 1.09 (0.87-
                                                                                 1.26)
                                                                                               NS
                                                                                          CV death: RR rehab 1.16
                                                                                 (0.88-1.52)
                                                                                               NS

                                                                                 6) CHF: NR


Ornish 1998   RCT      N overall:      Secondary       1) Intensive lifestyle    Primary study outcome(s):                  None reported
                       48              prevention      management counseling     Change in coronary atherosclerosis over
                                                       (Ornish program) n = 28   5 year f/u
                       N women:        Moderate to
                       3               severe CAD      2) Usual care (n = 20)    Clinical endpoints of interest:
                                       on                                        1) Composite outcome(s):
                       Mean age:       catherization                             Any cardiac event including MI, revasc,
                       57.4-61.8                                                 cardiac hospitalization, CABG, PTCA,
                                                                                 CHD death:
                       Age range: NR                                             Exp       25/28
                                                                                 Control 45/20 RR 2.47 (1.48-4.20)
                       % Diabetics:                                              p < 0.001
                       NR
                                                                                 2) Heart attack/MI:
                       % Caucasian:                                              Exp      2/28
                       NR                                                        Control 4/20 RR 2.74 (0.39-30.3)
                                                                                 p < 0.26

                                                                                 3) Stroke (hemorrhagic, non-
                                                                                 hemorrhagic, TIA): NR

                                                                                 4) Revascularization procedure (PCI,
                                                                                 bypass):
                                                                                 PTCA
                                                                                 Exp      8/28
                                                                                 Control 14/20 RR 2.40 (0.94-6.60)
                                                                                 p<0.05



                                                                            Page 9 of 16
Study    Design   No. of           Patient       Interventions               Outcomes                                  Subgroup Analyses of        Notes
                  Patients         Population                                                                          Clinical Endpoints in
                                                                                                                       Women

                                                                             CABG
                                                                             Exp     2/28
                                                                             Control 5/20 RR 3.43 (0.56-36.0) p =
                                                                             0.14

                                                                             5) Death/mortality:
                                                                             Exp      2/28
                                                                             Control 1/20 RR 0.69 (0.01-13.2)
                                                                             p = 0.81

                                                                             6) CHF: NR

PRECOR   RCT      N overall: 182   Secondary     1) Rehab – exercise         Primary study outcome(s):                 Not applicable (no women)
Group                              prevention    (biking 3x/wk for 25 min)   Exercise tolerance, return to work,
1991              N women:                       + counseling on risk        changes in health behaviors, morbidity,
                  0                Status post   factors x 6 weeks (n =      mortality
                                   MI            60)
                  Mean age:                                                  Clinical endpoints of interest:
PRECOR            Rehab 51                       2) Risk factor counseling   1) Composite outcome(s): NR
                  Counseling 51                  alone (n = 61)
                  Usual care 49                                              2) Heart attack/MI: (not significant)
                                                 3) Usual care (n = 61)          Rehab: 7/60
                  Age range:                                                     Counseling: 7/61
                  < 65                                                           Usual care: 10/61

                  % Diabetics:                                               3) Stroke (hemorrhagic, non-
                  NR                                                         hemorrhagic, TIA): NR

                  % Caucasian:                                               4) Revascularization procedure (PCI,
                  NR                                                         bypass):
                                                                               PCI not reported
                                                                               CABG: not significant
                                                                                 Rehab: 3%
                                                                                 Counseling: 2%
                                                                                 Usual care: 2%

                                                                             5) Death/mortality:
                                                                                  Rehab: 0/60
                                                                                  Counseling: 5/61 (8%)
                                                                                  Usual care: 4/61 (7%)
                                                                             Difference for Rehab vs Couns+UC is



                                                                      Page 10 of 16
Study        Design   No. of           Patient       Interventions               Outcomes                                 Subgroup Analyses of        Notes
                      Patients         Population                                                                         Clinical Endpoints in
                                                                                                                          Women
                                                                                 significant (p 0.03)

                                                                                 6) CHF:
                                                                                     Rehab: 12%
                                                                                     Counseling: 10%
                                                                                     Usual care: 11%



Rechnitzer   RCT      N overall: 733   Secondary     1) High-intensity           Primary study outcome(s):                Not applicable (no women)   Very high
1983                                   prevention    exercise (HIE) program      Recurrent MI                                                         dropout
                      N women:                       (n = 379) walking or                                                                             rates HIE =
                      0                Status post   jogging @ 65-85%            Clinical endpoints of interest:                                      45.9%
                                       MI            estimated VO2 over 4        1) Composite outcome(s): NR                                          LIE =
Ontario               Mean age: NR                   years                                                                                            44.9%
Exercise-                                                                        2) Heart attack/MI: (fatal & nonfatal)
Heart                 Age range: 26-                 2) Low intensity exercise   HIE 14.2%
Collabora-            56                             (LIE) program (n = 354)     LIE 13.0%
tive Study                                           weekly supervised           RR 1.09
                      % Diabetics:                   recreational activities
                      NR                             volleyball, swimming or     3) Stroke (hemorrhagic, non-
                                                     bowling HR <50% of max      hemorrhagic, TIA): NR
                      % Caucasian:                   VO2
                      NR                                                         4) Revascularization procedure (PCI,
                                                                                 bypass): NR

                                                                                 5) Death/mortality: NR

                                                                                 6) CHF: NR


Roman 1983   RCT      N overall: 193   Secondary     1) Cardiac rehab:           Primary study outcome(s):                None reported               Rate of
                                       prevention    supervised exercise 30      Mortality at 9 yr f/u                                                angina
                      N women: 19                    min 3x/week for mean of                                                                          significantly
                                       Status post   42 months. (n = 93)         Clinical endpoints of interest:                                      lower in
                      Mean age:        MI                                        1) Composite outcome(s): NR                                          rehab group
                      54.5                           2) Usual care (n = 100)                                                                          o/w
                                                                                 2) Heart attack/MI:                                                  Comparison
                      Age range: 32-                                                  Rehab: 16/93 (3.6%/yr)                                          s NS
                      71                                                              Control: 23/100 (5.0%/yr) not
                                                                                 significant




                                                                         Page 11 of 16
Study        Design   No. of           Patient       Interventions              Outcomes                                  Subgroup Analyses of        Notes
                      Patients         Population                                                                         Clinical Endpoints in
                                                                                                                          Women
                      % Diabetics:
                      19                                                        3) Stroke (hemorrhagic, non-
                                                                                hemorrhagic, TIA):
                      % Caucasian                                                   Rehab 3/93
                      NR                                                            Control: 1/100 p = NS

                                                                                4) Revascularization procedure (PCI,
                                                                                bypass): NR

                                                                                5) Death/mortality:
                                                                                    Total: Rehab 16/93 (3.6%/year)
                                                                                           Control 27/100 (5.8%/year)
                                                                                NS
                                                                                    Cardiac: Rehab 13/93 (2.9%/yr)
                                                                                           Control 24/100 (5.2%/yr)
                                                                                NS

                                                                                6) CHF: Rehab 6/93
                                                                                         Control 10/100    NS


Shaw 1981    RCT      N overall: 651   Secondary     1) Supervised exercise     Primary study outcome(s): Mortality and   Not applicable (no women)
                                       prevention    3x/week for 1hr x 8        cardiovascular mortality
                      N women: 0                     weeks in lab then
                                       Status post   switched to gym and        Clinical endpoints of interest:
National              Mean age:        MI            3x/week for 40 minutes     1) Composite outcome(s): NR
Exercise &            Rehab 51.5                     for up to 34 months (n =
Heart                 Control 52.0                   323)                       2) Heart attack/MI:
Disease                                                                         Exercise 17/323 (5.3%)
Project               Age range: 30-                 2) usual care (n = 328)    Usual care 23/328 (7.0%)
                      64                                                        P = 0.40

                      % Diabetics:                                              3) Stroke (hemorrhagic, non-
                      NR                                                        hemorrhagic, TIA): NR

                      % Caucasian                                               4) Revascularization procedure (PCI,
                      NR                                                        bypass):NR

                                                                                5) Death/mortality:

                                                                                Total
                                                                                Exercise 15/323 (4.6%)



                                                                         Page 12 of 16
Study       Design   No. of           Patient       Interventions                Outcomes                                    Subgroup Analyses of        Notes
                     Patients         Population                                                                             Clinical Endpoints in
                                                                                                                             Women
                                                                                 Control   24/328 (7.3%) p = 0.22

                                                                                 CV death
                                                                                 Exercise 14/323 (4.6%)
                                                                                 Control 20/328 (6.1%) p = 0.40

                                                                                 6) CHF: NR


Specchia    RCT      N overall: 256   Secondary     1) 4 weeks of supervised     Primary study outcome(s):                   Not applicable (no women)   Did show a
1996                                  prevention    exercise training with 30    Survival after mean f/u 34.5 months post                                significant
                     N women:                       min biking 5x/week +         MI                                                                      decrease in
                     0                Status post   calisthenics. After                                                                                  cardiac
                                      MI            4weeks instructed to         Clinical endpoints of interest:                                         death in pts
                     Mean age: NR                   continue calisthenics and    1) Composite outcome(s): NR                                             with EF
                                                    walk > 30 mins 3-                                                                                     40% with
                     Age range:                     4x/week (n = 135)            2) Heart attack/MI: NR                                                  CR
                     < 65 y                                                                                                                              participation
                                                    2) Control (n = 131)         3) Stroke: NR                                                           .
                     % Diabetics:
                     16                                                          4) Revascularization procedure (PCI,
                                                                                 bypass):
                     % Caucasian:                                                Rehab: 12/135
                     NR                                                          Control: 8/131
                                                                                 p = NS

                                                                                 5) Death/mortality:
                                                                                 Cardiac death
                                                                                 Rehab 5/125
                                                                                 Control 13/131
                                                                                 P = NS

                                                                                 6) CHF: NR


Vermeulen   RCT      N overall:       Secondary     1) Multi-disciplinary CR     Primary study outcome(s):                   Not applicable (no women)   Only
1983                 78               prevention    including exercise x 6       Changes in coronary risk factors (BP,                                   combined
                                                    weeks (n = 47)               smoking, cholesterol) & prognosis at 5 yr                               endpoints
                     N women:         Status post                                                                                                        significant
                     0                MI            2) Usual care (n = 51)       Clinical endpoints of interest:
                                                                                 1) Composite outcome(s): Progressive




                                                                           Page 13 of 16
Study     Design   No. of           Patient       Interventions               Outcomes                                   Subgroup Analyses of    Notes
                   Patients         Population                                                                           Clinical Endpoints in
                                                                                                                         Women
                   Mean age:                                                  CAD (severe angina or recurrent MI)
                   Rehab 49.4                                                   Rehab: 8/47
                   Control 49.1                                                 Control: 19/51 p<0.05

                   Age range: 40-                                             Progressive CAD or death:
                   55                                                            Rehab: 10/47
                                                                                 Control: 24/51 p<0.02
                   % Diabetics:
                   NR                                                         2) Heart attack/MI:
                                                                              Rehab 4/47 (8.5%)
                   % Caucasian:                                               Control 9/51 (17.6%)
                   NR
                                                                              3) Stroke (hemorrhagic, non-
                                                                              hemorrhagic, TIA): NR

                                                                              4) Revascularization procedure (PCI,
                                                                              bypass): NR

                                                                              5) Death/mortality: (all cardiac)
                                                                                  Rehab: 2/47
                                                                                  Control: 5/51 NS

                                                                              6) CHF: NR


Wallner   RCT      N overall: 60    Secondary     1) Lifestyle intervention   Primary study outcome(s):                  None reported
1999                                prevention    group: intensified diet &   Need for further revascularization after
                   N women: 13                    exercise counseling on      successful PTCA
                                    Status post   routine basis in
                   Mean age:        PTCA          metabolism clinic x 1 yr    Clinical endpoints of interest:
                   58-60                          (including suggestion to    1) Composite outcome(s): NR
                                                  exercise 3x/ wk for 30
                   Age range:                     min) (n = 28)               2) Heart attack/MI: NR
                   SD 7-8
                                                  2) Usual care: baseline     3) Stroke (hemorrhagic, non-
                   % Diabetics: 0                 diet and exercise           hemorrhagic, TIA): NR
                                                  counseling (n = 32)
                   % Caucasian:                                               4) Revascularization procedure (PCI,
                   NR                                                         bypass):
                                                                              Lifestyle 3/28 (2 PTCA, 1 CABG)
                                                                              Control 14/32 (13 PTCA, 1 CABG)
                                                                              RR 0.26 (0.09-0.74), p = 0.0055



                                                                        Page 14 of 16
Study           Design     No. of             Patient          Interventions                 Outcomes                                      Subgroup Analyses of               Notes
                           Patients           Population                                                                                   Clinical Endpoints in
                                                                                                                                           Women

                                                                                             5) Death/mortality: NR

                                                                                             6) CHF: NR




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