April 25 - College of Pharmacy

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April 25 - College of Pharmacy Powered By Docstoc
					  Congratulations and Best Wishes to Our 2009 Dalhousie Pharmacy
“In the News” – April 25 – May 15, 2009 – Drug- and Pharmacy-Related News Brought to You
                              by the Pharmacy Library People

                                      Basic Sciences Research

Gilpin RK, Gilpin CS. Pharmaceuticals and Related Drugs. Anal Chem. 2009 May
6. [Epub ahead of print].

Zhao H, Guo Z. Medicinal chemistry strategies in follow-on drug discovery.
Drug Discov Today. 2009 May;14(9-10):516-22.


The following study and editorial are related:

       Pellegrini CN, Vittinghoff E, Lin F et al. Statin use is associated with lower risk of atrial
       fibrillation in women with coronary disease: The HERS trial. Heart. 2009

       Ashikaga H, Marine JE. Prevention of atrial fibrillation: Another good reason
       to recommend statins to women?. Heart. 2009 May;95(9):693-4.

The following article and commentary are related:

       Oake N, van Walraven C, Rodger MA et al. Effect of an interactive voice
       response system on oral anticoagulant management. CMAJ. 2009 Apr

       Gurwitz JH. Can anticoagulation care be improved with technology? CMAJ. 2009
       Apr 28;180(9):909-10

Melnikova I. The anticoagulants market. Nat Rev Drug Discov. 2009 May;8(5):353-4.

The following article, editorial and patient summary are related:

       Prandoni P, Prins MH, Lensing AW et al; AESOPUS Investigators. Residual thrombosis on
       ultrasonography to guide the duration of anticoagulation in patients with deep venous
       thrombosis: A randomized trial. Ann Intern Med. 2009 May 5;150(9):577-85.

       Goldhaber SZ. Optimal duration of anticoagulation after venous
       thromboembolism: Fixed and evidence-based, or flexible and personalized? Ann
       Intern Med. 2009 May 5;150(9):644-6.

       Summaries for patients. Residual thrombosis to guide the duration of
       anticoagulation. Ann Intern Med. 2009 May 5;150(9):I-44.

Stone GW, Lansky AJ, Pocock SJ et al; HORIZONS-AMI Trial Investigators. Paclitaxel-eluting
stents versus bare-metal stents in acute myocardial infarction. N Engl J Med. 2009 May

Blasco-Colmenares E, Perl TM, Guallar E et al. Aspirin plus clopidogrel and risk of
infection after coronary artery bypass surgery. Arch Intern Med. 2009 Apr

James SK, Stenestrand U, Lindbäck J et al; SCAAR Study Group. Long-term safety and efficacy of
drug-eluting versus bare-metal stents in Sweden. N Engl J Med. 2009 May

Raine R, Wong W, Ambler G, et al. Sociodemographic variations in the contribution of
secondary drug prevention to stroke survival at middle and older ages: cohort study. BMJ.
2009 Apr 16;338:b1279.

Dobesh PP, Stacy ZA, Persson EL. Pharmacologic therapy for intermittent
claudication. Pharmacotherapy. 2009 May;29(5):526-53.

Björklund L, Wallander MA, Johansson S et al. Aspirin in
cardiology--benefits and risks. Int J Clin Pract. 2009 Mar;63(3):468-77. Review.

The following story and comment are related:

       Teerlink JR, Metra M, Felker GM et al. Relaxin for thetreatment of patients with acute
       heart failure (Pre-RELAX-AHF): A multicentre,randomised, placebo-controlled, parallel-
       group, dose-finding phase IIb study. Lancet. 2009 Apr 25;373(9673):1429-39.

       Hernandez AF, Granger CB. Advancing care for acute heart failure--no time to
       relax. Lancet. 2009 Apr 25;373(9673):1401-2.

Zimetbaum PJ. Dronedarone for atrial fibrillation--an odyssey. N Engl J Med.
2009 Apr 30;360(18):1811-3.

Anderson GD, Carr DB. Effect of pregnancy on the pharmacokinetics of antihypertensive drugs.
Clin Pharmacokinet. 2009;48(3):159-68.

The following two articles are related:

       McDermott MM, Criqui MH. Aspirin and secondary prevention in peripheral artery
       disease: A perspective for the early 21st century. JAMA. 2009 May 13;301(18):1927-8.
       Berger JS, Krantz MJ, Kittelson JM et al.

        Aspirin for the prevention of
       cardiovascular events in patients with peripheral artery disease: A meta-analysis
       of randomized trials. JAMA. 2009 May 13;301(18):1909-19.

Torpy JM, Lynm C, Glass RM. JAMA patient page. Heart failure. JAMA. 2009 May

Stone GW, Lansky AJ, Pocock SJ et al for the HORIZONS-AMI Trial Investigators. Paclitaxel-
eluting stents versus bare-metal stents in acute myocardial infarction. N Engl J Med. 2009 May

Alkhateeb FM, Khanfar NM, Doucette WR et al. Characteristics of physicians targeted by the
pharmaceutical industry to participate in e-detailing. Health Mark Q. 2009 Apr;26(2):98-116.

Lu CY. Observational studies: A review of study designs, challenges and strategies to reduce
confounding. Int J Clin Pract. 2009 May;63(5):691-7.

Shetty VV, Karve AV. Promotional literature: How do we critically appraise? J Postgrad Med.
2008 Jul-Sep;54(3):217-21.

Straus S, Haynes RB. Managing evidence-based knowledge: The need for reliable,
relevant and readable resources. CMAJ. 2009 Apr 28;180(9):942-5.


Cancer pill 'offers MS benefits': Courses of a common cancer drug can dramatically reduce the risk of a
patient with multiple sclerosis having a relapse or deterioration, work shows. BBC News. April 29, 2009.

Zheng L, Mack WJ, Dagerman KS et al. Metabolic changes associated with
second-generation antipsychotic use in Alzheimer's disease patients: The CATIE-AD
study. Am J Psychiatry. 2009 May;166(5):583-90.

Eyal S, Hsiao P, Unadkat JD. Drug interactions at the blood-brain barrier: Fact or fantasy?
Pharmacol Ther. 2009 Apr 22.

Huskamp HA, Busch AB, Domino ME, Normand SL. Antidepressant reformulations:
who uses them, and what are the benefits? Health Aff (Millwood). 2009 May-Jun;28(3):734-45.

Stein MA, Kanner AM. Management of newly diagnosed epilepsy: A practical guide
to monotherapy. Drugs. 2009;69(2):199-222

Perlis RH. Effective agents in treating mania. J Clin Psychiatry. 2009 Apr;70(4):e08.

Wisniewski SR, Rush AJ, Nierenberg AA et al. Can phase III trial results of
antidepressant medications be generalized to clinical practice? A STAR*D report.
Am J Psychiatry. 2009 May;166(5):599-607.

Barnes DE, Covinsky KE, Whitmer RA et al. Predicting risk of dementia in older adults. The late-
life dementia risk index. Neurology. 2009 May 13.

Williams JW Jr, Ranney L, Morgan LC et al. How reviews covered the unfolding scientific story
of gabapentin for bipolar disorder. Gen Hosp Psychiatry. 2009 May-Jun;31(3):279-87.


de Berker D. Clinical practice. Fungal nail disease. N Engl J Med. 2009 May 14;360(20):2108-

Saint Louis C. Confused by SPF? Take a number. New York Times. May 14, 2009.

Walling HW. Primary hyperhidrosis increases the risk of cutaneous infection: A
case-control study of 387 patients. J Am Acad Dermatol. 2009 Apr 21.

Berra B, Rizzo AM. Glycemic index, glycemic load, wellness and beauty: The state of the art.
Clin Dermatol. 2009 Mar-Apr;27(2):230-5.

Berra B, Rizzo AM. Melatonin: Circadian rhythm regulator, chronobiotic, antioxidant and
beyond. Clin Dermatol. 2009 Mar-Apr;27(2):202-9.

The following three stories and editorial are related:

       Dumville JC, Worthy G, Bland JM et al; VenUS II team. Larval therapy for leg ulcers
       (VenUS II): Randomised controlled trial. BMJ. 009 Mar 19;338:b773.

       Soares MO, Iglesias CP, Bland JM, et al; VenUS II team. Cost effectiveness analysis of
       larval therapy for leg ulcers. BMJ. 2009 Mar 19;338:b825.

       O'Meara S, Tierney J, Cullum N et al. Four layer bandage compared with short stretch
       bandage for venous leg ulcers: Systematic review and meta-analysis of randomised
       controlled trials with data from individual patients. BMJ. 2009 Apr 17;338:b1344.

       Grey JE, Leaper D, Harding K. How to measure success in treating chronic leg
       ulcers. BMJ. 2009 Apr 17;338:b1434.


Opar A. Diabetes drugs pass cardiovascular risk check. Nat Rev Drug Discov. 2009 May;8(5):343-

Ko GT, So WY, Tong PC et al. Effect of interactions between C peptide levels and insulin
treatment on clinical outcomes among patients with type 2 diabetes mellitus. CMAJ. 2009 Apr

Balakumar P, Arora MK, Ganti SS et al. Recent advances in pharmacotherapy for diabetic
nephropathy: Current perspectives and future directions. Pharmacol Res. 2009 Jul;60(1):24-

Pryce R. Diabetic ketoacidosis caused by exposure of insulin pump to heat and sunlight. BMJ.
2009 Jan 5;338:a2218.

Hviid A, Svanström H. Antibiotic use and type 1 diabetes in childhood. Am J Epidemiol. 2009
May 1;169(9):1079-84.

Chaput JP, Després JP, Bouchard C et al. Sleep duration as a risk factor for the development of
type 2 diabetes or impaired glucose tolerance: Analyses of the Quebec Family Study. Sleep
Med. 2009 Mar 28.

Gupta AK, Smith SR, Greenway FL et al. Pioglitazone treatment in type 2 diabetes mellitus
when combined with portion control diet modifies the metabolic syndrome. Diabetes Obes
Metab. 2009 Apr;11(4):330-7.

Doucette WR, Witry MJ, Farris KB et al. Community pharmacist-provided extended diabetes
care. Ann Pharmacother. 2009 May;43(5):882-9.

                              Drug Compounding & Biopharmaceutics

Sunenshine R, Schultz M, Lawrence MG et al. An outbreak of postoperative gram-negative
bacterial endophthalmitis associated with contaminated trypan blue ophthalmic solution. Clin
Infect Dis. 2009 Jun 1;48(11):1580-3.

Ahmadian S, Fakhree MA. Earwax (cerumen) might be formulated into a safe and
biodegradable insect repellent. Med Hypotheses. 2009 Mar;72(3):370-1.

Dupuis A, Tournier N, Le Moal G et al. Preparation and stability of voriconazole eye drop
solution. Antimicrob Agents Chemother. 2009 Feb;53(2):798-9.

Oishi R. Current status of preparation and distribution of medicines. Am J Health Syst Pharm.
2009 Mar 1;66(5 Suppl 3):S35-42. Review.

Lee SH, Woo SJ, Park KH et al. Serratia marcescens endophthalmitis associated with intravitreal
injections of bevacizumab. Eye. 2009 May 1. [Epub ahead of print].

Lay PC. Injectable immunotherapy: Recommendations for safe allergen vial preparation in the
office setting. Curr Opin Otolaryngol Head Neck Surg. 2009 Apr 23. [Epub ahead of print].

                                            Drug Safety

Solomon DH, Rekedal L, Cadarette SM. Osteoporosis treatments and adverse events. Curr Opin
Rheumatol. 2009 Apr 30. [Epub ahead of print].

Ruggiero SL. Bisphosphonate-related osteonecrosis of the jaw (BRONJ): Initial
discovery and subsequent development. J Oral Maxillofac Surg. 2009 May;67(5

Grosso A, Douglas I, Hingorani A et al. Oral bisphosphonates and risk of atrial fibrillation and
flutter in women: A self-controlled case-series safety analysis. PLoS ONE. 2009;4(3):e4720.

Ederhy S, Cohen A, Dufaitre G et al. QT interval prolongation among patients treated
with angiogenesis inhibitors. Target Oncol. 2009 May 6. [Epub ahead of print].

Chen Y, Guo JJ, Patel NC. Hemorrhagic stroke associated with antidepressant use in patients
with depression: Does degree of serotonin reuptake inhibition matter? Pharmacoepidemiol
Drug Saf. 2009 Mar;18(3):196-202.

Billups SJ, Delate T, Dugan D. Evaluation of risk factors for elevated tricyclic antidepressant
plasma concentrations. Pharmacoepidemiol Drug Saf. 2009 Mar;18(3):253-7.

Simoni-Wastila L, Ryder PT, Qian J et al. Association of antipsychotic use with hospital events
and mortality among medicare beneficiaries residing in long-term care facilities. Am J Geriatr
Psychiatry. 2009 May;17(5):417-27.

Li M, Andrew MA, Wang J et al. Effects of cranberry juice on the pharmacokinetics of beta-
lactam antibiotics following oral administration. Antimicrob Agents Chemother. 2009 Apr
27. [Epub ahead of print].

van der Sijs H, Kowlesar R, Aarts J et al. Unintended consequences of reducing QT-alert
overload in a computerized physician order entry system. Eur J Clin Pharmacol. 2009 May 5.
[Epub ahead of print].

Grieco A, Miele L, Pompili M et al. Acute hepatitis caused by a natural lipid-lowering product:
when "alternative" medicine is no "alternative" at all. J Hepatol. 2009 Jun;50(6):1273-7.

Brambilla G, Mattioli F, Martelli A. Genotoxic and carcinogenic effects of
antipsychotics and antidepressants. Toxicology. 2009 Apr 30. [Epub ahead of

Bohlius J, Schmidlin K, Brillant C et al. Recombinant human erythropoiesis-stimulating
agents and mortality in patients with cancer: a meta-analysis of randomised
trials. Lancet. 2009 May 2;373(9674):1532-42.

                      Emergency Medicine, Intensive Care & Critical Care

Dart RC, Borron SW, Caravati EM et al for the Antidote Summit Authorship Group. Expert
consensus guidelines for stocking of antidotes in hospitals that provide emergency care. Ann
Emerg Med. 2009 Apr 29.

Heintz BH, Matzke GR, Dager WE. Antimicrobial dosing concepts and recommendations for
critically ill adult patients receiving continuous renal replacement therapy or intermittent
hemodialysis. Pharmacotherapy. 2009 May;29(5):562-77.

Camiré E, Moyen E, Stelfox HT. Medication errors in critical care: risk factors, prevention and
disclosure. CMAJ. 2009 Apr 28;180(9):936-43.

The following study, editorial and letter to the editor are related:

        Eppert HD, Eppert JA. In response to "The unexpected challenges of accurate
        medication reconciliation". Ann Emerg Med. 2009 Apr;53(4):548-9.

        Schenkel S. The unexpected challenges of accurate medication reconciliation.
        Ann Emerg Med. 2008 Nov;52(5):493-5.

        Miller SL, Miller S, Balon J, Helling TS. Medication reconciliation in a rural
        trauma population. Ann Emerg Med. 2008 Nov;52(5):483-91.

Roberts JA, Webb SA, Paterson DL et al. A systematic review on
clinical benefits of continuous administration of beta-lactam antibiotics. Crit
Care Med. 2009 Apr 20. [Epub ahead of print].

Alexander E. Delirium in the intensive care unit: medications as risk factors. Crit Care Nurse.
2009 Feb;29(1):85-7.

Lam SW, Eschenauer GA, Carver PL. Evolving role of early antifungals in the adult intensive care
unit. Crit Care Med. 2009 May;37(5):1580-93.

                                    Endocrine System Diseases

Allahabadia A, Razvi S, Abraham P, Franklyn J. Diagnosis and treatment of primary
hypothyroidism. BMJ. 2009 Mar 26;338:b725. doi: 10.1136/bmj.b725.

                                     Environmental Concerns

The following review and editorial are related:

       Wong CS, MacLeod SL. JEM spotlight: recent advances in analysis of pharmaceuticals in
       the aquatic environment. J Environ Monit. 2009 May;11(5):923-36.

      Escher B. Foreword: JEM spotlight: recent advances in analysis of pharmaceuticals in the
      aquatic environment. J Environ Monit. 2009 May;11(5):921-2.

Sanderson H, Thomsen M. Comparative analysis of pharmaceuticals versus industrial chemicals
acute aquatic toxicity classification according to the United Nations classification system for
chemicals. Assessment of the (Q)SAR predictability of pharmaceuticals acute aquatic toxicity
and their predominant acute toxic mode-of-action. Toxicol Lett. 2009 Jun 1;187(2):84-93.

Grün F, Blumberg B. Endocrine disrupters as obesogens. Mol Cell Endocrinol.
2009 May 25;304(1-2):19-29.

Larsbo M, Lapen DR, Topp E et al. Simulation of pharmaceutical and personal care product
transport to tile drains after biosolids application. J Environ Qual. 2009 Apr 27;38(3):1274-85.

Handa A, Webster P. Industry-led committee urges delay in closing loophole allowing import of
unapproved antibiotics for animals. CMAJ. 2009 Apr 28;180(9):914-6.


Banning M. A review of interventions used to improve adherence to medication in older
people. Int J Nurs Stud. 2009 Apr 23. [Epub ahead of print].

                                    Gastrointestinal Diseases

Di Sabatino A, Corazza GR. Coeliac disease. Lancet. 2009 Apr 25;373(9673):1480-93.

Mehuys E, Van Bortel L, De Bolle L et al. Self-medication of upper gastrointestinal symptoms: a
community pharmacy study. Ann Pharmacother. 2009 May;43(5):890-8.

                                      Hematologic Diseases

Nurden AT, Viallard JF, Nurden P. New-generation drugs that stimulate platelet production in
chronic immune thrombocytopenic purpura. Lancet. 2009 May 2;373(9674):1562-9.

                                    Immune System Diseases

Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. Lancet. 2009 May

                                       Infectious Diseases

Silversides A. World must respond to threat of drug-resistant tuberculosis.
CMAJ. 2009 May 12;180(10):E37.

Centers for Disease Control and Prevention (CDC). Update: drug susceptibility
of swine-origin influenza A (H1N1) viruses, April 2009. MMWR Morb Mortal Wkly
Rep. 2009 May 1;58(16):433-5.

Hupfeld J, Efferth T. Review. Drug resistance of human immunodeficiency virus
and overcoming it by natural products. In Vivo. 2009 Jan-Feb;23(1):1-6.

Bounthavong M, Hsu DI, Okamoto MP. Cost-effectiveness analysis of linezolid
vs. vancomycin in treating methicillin-resistant Staphylococcus aureus
complicated skin and soft tissue infections using a decision analytic model. Int
J Clin Pract. 2009 Mar;63(3):376-86.

The following “clinical crossroads” feature and patient page are related:

       Torpy JM, Lynm C, Glass RM. JAMA patient page. Acute sinusitis. JAMA. 2009 May

       Hwang PH. A 51-year-old woman with acute onset of facial pressure, rhinorrhea,
       and tooth pain: review of acute rhinosinusitis. JAMA. 2009 May 6;301(17):1798-807.

The following perspective, editorial and study are related:

       Ford N, Mills E, Calmy A. Rationing antiretroviral therapy in Africa—treating too few, too
       late. N Engl J Med. 2009 Apr 30;360(18):1808-10.

       Kitahata MM, Gange SJ, Abraham AG et al for the NA-ACCORD Investigators. Effect of
       early versus deferred antiretroviral therapy for HIV on survival. N Engl J Med. 2009 Apr

       Sax PE, Baden LR. When to start antiretroviral therapy--ready when you are?. N Engl J
       Med. 2009 Apr 30;360(18):1897-9.

The following two studies and editorial are related:

       Hoofnagle JH. A step forward in therapy for hepatitis C. N Engl J Med. 2009
       Apr 30;360(18):1899-901.

       Hézode C, Forestier N, Dusheiko G et al for the PROVE2 Study Team. Telaprevir and
       peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med.
       2009 Apr 30;360(18):1839-50.

       McHutchison JG, Everson GT, Gordon SC et al for the PROVE1 Study Team. Telaprevir
       with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med.
       2009 Apr 30;360(18):1827-38.

The following study and editorial are related:

       Hay AD, Jüttner KV. Antibiotics for acute cough in primary care. BMJ. 2009 May
       5;338:b834. doi: 10.1136/bmj.b834.

       Cals JW, Butler CC, Hopstaken RM et al. Effect of point of care testing for C reactive
       protein and training in communication skills on antibiotic use in lower respiratory tract
       infections: cluster randomised trial. BMJ. 2009 May 5;338:b1374. doi: .1136/bmj.b1374.

                                        Kidney Diseases

Churchwell MD, Mueller BA. Drug dosing during continuous renal replacement
therapy. Semin Dial. 2009 Mar-Apr;22(2):185-8.

Chiu YW, Teitelbaum I, Misra M et al. Pill burden, adherence, hyperphosphatemia, and quality
of life in maintenance dialysis patients. Clin J Am Soc Nephrol. 2009 May 7. [Epub ahead of

Levey AS, Stevens LA, Schmid CH et al for the Chronic Kidney Disease Epidemiology
Collaboration. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009
May 5;150(9):604-12.

                                              Men’s Health

The following guideline and editorial are related:

       Droller MJ. A guideline for discussion and some thoughts. J Urol. 2009 Apr;181(4):1530-
       1. Epub 2009 Feb 26.

       Kramer BS, Hagerty KL, Justman S et al for the American Society of Clinical
       Oncology/American Urological Association. Use of 5alpha-reductase inhibitors for
       prostate cancer chemoprevention: American Society of Clinical Oncology/American
       Urological Association 2008 Clinical Practice Guideline. J Urol. 2009 Apr;181(4):1642-57.

Nichol MB, Knight TK, Wu J et al. Evaluating use patterns of and adherence to medications for
benign prostatic hyperplasia. J Urol. 2009 May;181(5):2214-21; discussion 2221-2. Epub 2009
Mar 17.

Murphy AB, Macejko A, Taylor A, Nadler RB. Chronic prostatitis: management strategies. Drugs.

                                         News – Canada

Eggertson L. Canada lags US in adoption of e-prescribing. CMAJ. 2009 Apr 28;180(9):E25-6.

Talaga T. Health-care workers to get broader powers: Pharmacists, nurses, other professionals
will do some work of MDs. April 25, 2009.

Depression drug doubles in price for P.E.I. man. April 26, 2009.

Press release: CAMR federal law needs to be fixed if life-saving drugs for children are to be
developed. Toronto ON: Apotex; May 14, 2009.

                                     News – International

Associated Press. Swiss drug maker Roche donates over 5M packs of anti-viral Tamiflu to UN
health agency. May 12, 2009.

                                     News – United States

Sack K. Despite recession, personalized health care remains in demand. New York Times. May
11, 2009.

Stewart S. Pfizer offers free drugs to out-of-work Americans: Pharmaceutical giant among
many corporations gaining post-recession loyalty by being generous now. Globe and Mail. May
14, 2009.

Lee D. Pharmacists group decries WellPoint's plan to sell unit: Express Scripts' deal for NextRx
will have ill effect on consumers, association claims. April 29, 2009.


The following news story refers to a study published earlier in 2009:

       Beck L. Small steps to beat the creep. Globe and Mail. May 6, 2009.

       Hill JO. Can a small-changes approach help address the obesity epidemic? A
       report of the Joint Task Force of the American Society for Nutrition, Institute
       of Food Technologists, and International Food Information Council. Am J Clin
       Nutr. 2009 Feb;89(2):477-84.

Mello MM. New York City's war on fat. N Engl J Med. 2009 May 7;360(19):2015-20.

Thaler JP, Cummings DE. Hormonal and metabolic mechanisms of diabetes
remission after gastrointestinal surgery. Endocrinology. 2009 Apr 16. [Epub ahead
of print].

Encinosa WE, Bernard DM, Du D, Steiner CA. Recent improvements in bariatric
surgery outcomes. Med Care. 2009 May;47(5):531-5.

Marcus C, Nyberg G, Nordenfelt A et al. A 4-year,
cluster-randomized, controlled childhood obesity prevention study: STOPP. Int J
Obes (Lond). 2009 Apr;33(4):408-17.

Mercer SW, Lean ME. Request for slimming tablets. BMJ. 2008 Oct 24;337:a1287.
doi: 10.1136/bmj.a1287. Erratum in: BMJ. 2008;337:a2314.

                                    Obstetrics & Gynecology

The following three “practice parameter update” documents are related:

       Harden CL, Hopp J, Ting TY et al. Practice Parameter update: Management issues for
       women with epilepsy--focus on pregnancy (an evidence-based review): Obstetrical
       complications and change in seizure frequency. Report of the Quality Standards
       Subcommittee and Therapeutics and Technology Assessment Subcommittee of the
       American Academy of Neurology and American Epilepsy Society. Neurology. 2009 Apr
       27. [Epub ahead of print].

       Harden CL, Meador KJ, Pennell PB et al. Practice Parameter update: Management issues
       for women with epilepsy--focus on pregnancy (an evidence-based review):
       Teratogenesis and perinatal outcomes. Report of the Quality Standards Subcommittee
       and Therapeutics and Technology Subcommittee of the American Academy of
       Neurology and American Epilepsy Society. Neurology. 2009 Apr 27. [Epub ahead of

       Harden CL, Pennell PB, Koppel BS et al. Practice Parameter update: Management issues
       for women with epilepsy--focus on pregnancy (an evidence-based review): Vitamin K,
       folic acid, blood levels, and breastfeeding. Report of the Quality Standards
       Subcommittee and Therapeutics and Technology Assessment Subcommittee of the
       American Academy of Neurology and American Epilepsy Society. Neurology. 2009 Apr
       27. [Epub ahead of print].

The following study and editorial are related:

       Ionescu-Ittu R, Marelli AJ, Mackie AS, Pilote L. Prevalence of severe congenital heart
       disease after folic acid fortification of grain products: time trend analysis in Quebec,
       Canada. BMJ. 2009 May 12;338:b1673. doi: 10.1136/bmj.b1673.

       Gardiner HM, Fouron JC. Folic acid fortification and congenital heart disease.
       BMJ. 2009 May 12;338:b1144. doi: 10.1136/bmj.b1144.

The following clinical guidelines and summary for patients are related:

       Wolff T, Witkop CT, Miller T, Syed SB; U.S. Preventive Services Task Force.
       Folic acid supplementation for the prevention of neural tube defects: an update
       of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2009
       May 5;150(9):632-9.

       U.S. Preventive Services Task Force. Folic acid for the prevention of neural
       tube defects: U.S. Preventive Services Task Force recommendation statement. Ann
       Intern Med. 2009 May 5;150(9):626-31.

       Summaries for patients. Folic acid for the prevention of infant neural tube
       defects: U.S. Preventive Services Task Force recommendation. Ann Intern Med. 2009
       May 5;150(9):I-50.

American Dietetic Association; American Society of Nutrition, Siega-Riz AM,
King JC. Position of the American Dietetic Association and American Society for
Nutrition: obesity, reproduction, and pregnancy outcomes. J Am Diet Assoc. 2009

Carr DB, Newton KM, Utzschneider KM et al. Preeclampsia and risk of developing subsequent
diabetes. Hypertens Pregnancy. 2009 May 1:1-13.

Schatz M, Dombrowski MP. Clinical practice. Asthma in pregnancy. N Engl J Med.
2009 Apr 30;360(18):1862-9.

Wensel TM. Role of metformin in the treatment of gestational diabetes. Ann
Pharmacother. 2009 May;43(5):939-43.


Muss HB, Berry DA, Cirrincione CT et al for the CALGB Investigators. Adjuvant
chemotherapy in older women with early-stage breast cancer. N Engl J Med. 2009
May 14;360(20):2055-65.

Tonelli M, Hemmelgarn B, Reiman T et al. Benefits and harms of erythropoiesis-stimulating
agents for anemia related to cancer: a meta-analysis. CMAJ. 2009 Apr 30. [Epub ahead of print].

Gebara SN, Moubayed H. The role of the pharmacist in optimizing the use of
erythropoietin stimulating agents. J Oncol Pharm Pract. 2009 Apr 28. [Epub ahead
of print].

Scarpace SL, Brodzik FA, Mehdi S, Belgam R. Treatment of head and neck
cancers: issues for clinical pharmacists. Pharmacotherapy. 2009 May;29(5):578-92.

Navari RM. Pharmacological management of chemotherapy-induced nausea and
vomiting: focus on recent developments. Drugs. 2009;69(5):515-33.


Gunther JB, Altaweel MM. Bevacizumab (avastin) for the treatment of ocular disease.
Surv Ophthalmol. 2009 May-Jun;54(3):372-400.

                          OTCs, Nutrition, NHPs, Life Style Topics, etc.

Ray CC. Q & A: Vitamins on the menu. New York Times. May 5, 2009.

Streppel MT, Ocké MC, Boshuizen HC et al. Long-term wine consumption is related
tocardiovascular mortality and life expectancyindependently of moderate alcohol intake:
theZutphen Study. J Epidemiol Community Health. 2009 Apr 30. [Epub ahead of print].

Hawthorne KM, Abrams SA, Heird WC. Docosahexaenoic acid (DHA) supplementation
of orange juice increases plasma phospholipid DHA content of children. J Am Diet
Assoc. 2009 Apr;109(4):708-12.

                                     Pain & Palliative Care

The following synthesis of recommendations and editorial are related:

       Kroenke K, Krebs EE, Bair MJ. Pharmacotherapy of chronic pain: a synthesis of
       recommendations from systematic reviews. Gen Hosp Psychiatry. 2009

       Sullivan MD. The quest for rational chronic pain pharmacotherapy. Gen Hosp
       Psychiatry. 2009 May-Jun;31(3):203-5.

The following study and editorial are related:

       Apfel SC. Botulinum toxin for neuropathic pain? Neurology. 2009 Apr 28;72(17):1456-7.

       Yuan RY, Sheu JJ, Yu JM et al. Botulinum toxin for diabetic neuropathic pain: a
       randomized double-blind crossover trial. Neurology. 2009 Apr 28;72(17):1473-8.

Boyer R, McPherson ML, Deshpande G, Smith SW. Improving medication error
reporting in hospice care. Am J Hosp Palliat Care. 2009 May 5. [Epub ahead of

Chou R, Loeser JD, Owens DK et al for the American Pain Society Low Back Pain
Guideline Panel. Interventional therapies, surgery, and interdisciplinary rehabilitation for low
back pain: an evidence-based clinical practice guideline from the American Pain Society. Spine.
2009 May 1;34(10):1066-77.

Xian CJ, Zhou XF. Treating skeletal pain: limitations of conventional anti-inflammatory drugs,
and anti-neurotrophic factor as a possible alternative. Nat Clin Pract Rheumatol. 2009


The following review and editorial are related:

       Rader R, McCauley L, Callen EC. Current strategies in the diagnosis and treatment of
       childhood attention-deficit/hyperactivity disorder. Am Fam Physician. 2009 Apr

       Felt BT, Lumeng J, Christner J. Multimodal treatment of attention-deficit/hyperactivity
       disorder in children. Am Fam Physician. 2009 Apr 15;79(8):640, 642.

Harnden A, Takahashi M, Burgner D. Kawasaki disease. BMJ. 2009 May 5;338:b1514. doi:

Khine H, Weiss D, Graber N et al. A cluster of children with seizures caused by camphor
poisoning. Pediatrics. 2009 May;123(5):1269-72.

Huang JT, Abrams M, Tlougan B et al. Treatment of Staphylococcus aureus colonization in
atopic dermatitis decreases disease severity. Pediatrics. 2009 May;123(5):e808-14.

Agthe AG, Kim GR, Mathias KB et al. Clonidine as an adjunct therapy to opioids for neonatal
abstinence syndrome: a randomized, controlled trial. Pediatrics. 2009 May;123(5):e849-56.
Epub 2009 Apr 27.

de Jong J, van den Berg PB, Visser ST et al. Antibiotic usage, dosage and course length in
children between 0 and 4 years. Acta Paediatr. 2009 Apr 21. [Epub ahead of print].

Fletcher CV. Antiretroviral drug-drug interaction considerations for HIV-infected children.
Pediatr Infect Dis J. 2009 May;28(5):429-30.

de Vries TW, van den Berg PB, Duiverman EJ et al. Effect of a minimal pharmacy intervention
on improvement of adherence to asthma guidelines. Arch Dis Child. 2009 Apr 23. [Epub ahead
of print].

Thomson A, Maltezos S, Paliokosta E, Xenitidis K. Risperidone for attention-deficit hyperactivity
disorder in people with intellectual disabilities. Cochrane Database Syst Rev. 2009 Apr

                   Pharmacogenetics, Personalized Medicine, Genetics, etc.

The following study and commentary are related:

       Carter BL, Ernst ME. Thiazide-induced hyperglycemia: can it be prevented? Am
       J Hypertens. 2009 May;22(5):473.

       Bozkurt O, de Boer A, Grobbee DE et al. Variation in renin-angiotensin system and salt-
       sensitivity genes and the risk of diabetes mellitus associated with the use of thiazide
       diuretics. Am J Hypertens. 2009 May;22(5):545-51.

The following two commentaries are related:

       Leeder JS, Spielberg SP. Personalized medicine: reality and reality checks. Ann
       Pharmacother. 2009 May;43(5):963-6.

       Dean CE. Personalized medicine: boon or budget-buster? Ann Pharmacother. 2009

Cavallari LH, Momary KM. Genomics and the efficacy of aspirin in the treatment of
cerebrovascular disease. Curr Treat Options Cardiovasc Med. 2009 Jun;11(3):191-200.

Brambilla G, Martelli A. Genotoxicity and carcinogenicity studies of analgesics, anti-
inflammatory drugs and antipyretics. Pharmacol Res. 2009 Jul;60(1):1-17.

Hudson TJ. Personalized medicine: a transformative approach is needed. CMAJ.
2009 Apr 28;180(9):911-3.

Soldin OP, Mattison DR. Sex differences in pharmacokinetics and pharmacodynamics.
Clin Pharmacokinet. 2009;48(3):143-57.

                                   Respiratory Tract Diseases

Allen S, Britton J, Leonardi-Bee J. Association between antioxidant vitamins
and asthma outcomes: Systematic review and meta-analysis. Thorax. 2009 Apr 30.
[Epub ahead of print].


Kirkham SG, Samarasinghe RK. Review article: Glucosamine. J Orthop Surg (Hong
Kong). 2009 Apr;17(1):72-6.

Altman R, Barkin RL. Topical therapy for osteoarthritis: clinical and pharmacologic perspectives.
Postgrad Med. 2009 Mar;121(2):139-47.

                                     Socioeconomic Topics

The following three “perspectives” are related:

       Naik AD, Petersen LA. The neglected purpose of comparative-effectiveness
       research. N Engl J Med. 2009 May 7;360(19):1929-31.

       Avorn J. Debate about funding comparative-effectiveness research. N Engl J
       Med. 2009 May 7;360(19):1927-9.

       Garber AM, Tunis SR. Does comparative-effectiveness research threaten
       personalized medicine? N Engl J Med. 2009 May 7;360(19):1925-7.

Aronson JK. From prescription-only to over-the-counter medicines ('PoM to P'):
time for an intermediate category. Br Med Bull. 2009 May 3. [Epub ahead of print].

Levaggi R, Orizio G, Domenighini S et al. Marketing and pricing strategies of online pharmacies.
Health Policy. 2009 Apr 23. [Epub ahead of print].

The following study and commentary are related:

       Solomon MD, Goldman DP, Joyce GF, Escarce JJ. Cost sharing and the initiation of drug
       therapy for the chronically ill. Arch Intern Med. 2009 Apr 27;169(8):740-8; discussion

       Goff DC Jr, Greenland P. The change we need in health care. Arch Intern Med. 2009 Apr

Benson A, Cribb A, Barber N. Understanding pharmacists' values: A qualitative
study of ideals and dilemmas in UK pharmacy practice. Soc Sci Med. 2009 Apr 30.
[Epub ahead of print].

Sonderholm J. Paying a high price for low costs: why there should be no legal
constraints on the profits that can be made on drugs for tropical diseases. J Med
Ethics. 2009 May;35(5):315-9.

Oprea L, Braunack-Mayer A, Gericke CA. Ethical issues in funding research and
development of drugs for neglected tropical diseases. J Med Ethics. 2009

Civan A, Köksal B. The effect of newer drugs on health spending: do they
really increase the costs? Health Econ. 2009 Apr 29. [Epub ahead of print].

Murray MD, Ritchey ME, Wu J, Tu W. Effect of a pharmacist on adverse drug
events and medication errors in outpatients with cardiovascular disease. Arch
Intern Med. 2009 Apr 27;169(8):757-63.

Adams AS, Zhang F, LeCates RF et al. Prior authorization for antidepressants in
Medicaid: effects among disabled dual enrollees. Arch Intern Med. 2009 Apr

Weingart SN, Massagli M, Cyrulik A et al. Assessing the value of electronic prescribing in
ambulatory care: A focus group study. Int J Med Inform. 2009 Apr 21. [Epub ahead of print].

Tribble DA, Poikonen J, Blair J, Briley DC. Whither pharmacy informatics. Am J
Health Syst Pharm. 2009 May 1;66(9):813-5.

Purcell K. Use of performance portfolios for pharmacy personnel. Am J Health
Syst Pharm. 2009 May 1;66(9):801-4.

Barnett J, Jennings H. Pharmacy information systems in Canada. Stud Health
Technol Inform. 2009;143:131-5.

Nsimba SE. Problems associated with substandard and counterfeit drugs in
developing countries: a review article on global implications of counterfeit
drugs in the era of antiretroviral (ARVs) drugs in a free market economy. East
Afr J Public Health. 2008 Dec;5(3):205-10.

Elliott R. Non-adherence to medicines: not solved but solvable. J Health Serv
Res Policy. 2009 Jan;14(1):58-61.

von Gunten V, Reymond JP, Boubaker K et al. Antibiotic use: is appropriateness expensive?
J Hosp Infect. 2009 Feb;71(2):108-11.

The following study and editorial arte related:

       Dormuth CR, Neumann P, Maclure M et al. Effects of prescription coinsurance and
       income-based deductibles on net health plan spending for older users of inhaled
       medications. Med Care. 2009 May;47(5):508-16.

       Chernew M, Fendrick M. Clinically sensitive cost-sharing for prescription drugs:
       Thinking beyond the silos. Med Care. 2009 May;47(5):505-7.

Smith RE. Leadership in Pharmacy Practice: Why Me? (June). Ann Pharmacother.
2009 May 12. [Epub ahead of print].

Smith DH, Feldstein AC, Perrin NA et al. Improving laboratory monitoring of medications: an
economic analysis alongside a clinical trial. Am J Manag Care. 2009 May;15(5):281-9.

Civan A, Köksal B. The effect of newer drugs on health spending: do they
really increase the costs?. Health Econ. 2009 Apr 29. [Epub ahead of print].

Schnipper JL, Hamann C, Ndumele CD et al. Effect of an electronic medication
reconciliation application and process redesign on potential adverse drug events: A
cluster-randomized trial. Arch Intern Med. 2009 Apr 27;169(8):771-80.

Brockmeyer NH, Brucklacher U, Potthoff A, Reich-Schupke S. Off-label use in
dermatology in Germany: What has changed since 2004?. J Dtsch Dermatol Ges. 2009
Apr 6. [Epub ahead of print].

Makowsky MJ, Koshman SL, Midodzi WK, Tsuyuki RT. Capturing outcomes of
clinical activities performed by a rounding pharmacist practicing in a team
environment: The COLLABORATE Study [NCT00351676]. Med Care. 2009 May 8. [Epub
ahead of print].

                                        Sports Medicine

Toland S. Do sports creams rub the pain away? New York Times. May 7, 2009.

                                          Stats & Facts

Canadian pharmaceutical market outlook to 2013: Policy environment, market structure,
pipeline analysis, growth opportunities. London: Piribo Limited; March 2009.
(Please note: All that are freely accessible are the summary, table of contents and list of
figures; the full report is priced at more than $3000 in Canadian funds.)

                         Substance Use & Substance-related Disorders

Centers for Disease Control and Prevention (CDC). High school students who
tried to quit smoking cigarettes--United States, 2007. MMWR Morb Mortal Wkly Rep.
2009 May 1;58(16):428-31.

Daniulaityte R, Falck RS, Wang J, Carlson RG. Illicit use of pharmaceutical
opioids among young polydrug users in Ohio. Addict Behav. 2009 Apr 2. [Epub ahead
of print].

Garrison GD, Dugan SE. Varenicline: A first-line treatment option for smoking
cessation. Clin Ther. 2009 Mar;31(3):463-91.

Hsu WY, Chiu NY, Liao YC. Rhabdomyolysis and brain ischemic stroke in a

heroin-dependent male under methadone maintenance therapy. Acta Psychiatr Scand.
2009 Mar 10. [Epub ahead of print].

Stringer J, Welsh C, Tommasello A. Methadone-associated Q-T interval
prolongation and torsades de pointes. Am J Health Syst Pharm. 2009 May

                                      Tropical Medicine

Hotez PJ, Fenwick A, Savioli L, Molyneux DH. Rescuing the bottom billion
through control of neglected tropical diseases. Lancet. 2009 May

Oprea L, Braunack-Mayer A, Gericke CA. Ethical issues in funding research and
development of drugs for neglected tropical diseases. J Med Ethics. 2009

                                  Vaccines & Immunization

Westrick SC, Watcharadamrongkun S, Mount JK, Breland ML. Community pharmacy
involvement in vaccine distribution and administration. Vaccine. 2009 May

Omer SB, Salmon DA, Orenstein WA, deHart MP, Halsey N. Vaccine refusal,
mandatory immunization, and the risks of vaccine-preventable diseases. N Engl J
Med. 2009 May 7;360(19):1981-8.

                                       Women’s Health

Freeman EW, Rickels K, Sammel MD, Lin H, Sondheimer SJ. Time to relapse after
short- or long-term treatment of severe premenstrual syndrome with sertraline.
Arch Gen Psychiatry. 2009 May;66(5):537-44.

2: Lopez LM, Grimes DA, Schulz KF, Curtis KM. Steroidal contraceptives: effect on
bone fractures in women. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD006033.

Crandall CJ, Zheng Y, Crawford SL et al. Presence of vasomotor symptoms is associated with
lower bone mineral density: a longitudinal analysis. Menopause. 2008 Nov 7. [Epub ahead of

                       By & About Faculty, Students, Alumni & Friends

Whelan AM, Jurgens TM, Bowles SK, Doyle H. Efficacy of natural health products
in treating osteoporosis: what is the quality of internet patient advice?. Ann
Pharmacother. 2009 May;43(5):899-907.

Jurgens T, Whelan AM, Macdonald M, Lord L. Development and evaluation of an
instrument for the critical appraisal of randomized controlled trials of natural
products. BMC Complement Altern Med. 2009 Apr 23;9(1):11. [Epub ahead of print].

Smulders M. A line of defence against medication errors. April 27, 2009.
(. . . about the SafetyNET project; there is a photo of Neil MacKinnon plus quotes from him and
pharmacist, Sandeep Sodhi.)

                                  The End Until Next Time!!!


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