FRANCIS A

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					                    FRANCIS A. SYLVESTER, Ph.D.

ADDRESS
     221 Padnos Hall
     Grand Valley State University
     1 Campus Drive
     Allendale, MI 49401
     Phone: 616-331-8707
     Fax: 616-331-2090
     e-mail: sylvestf@gvsu.edu

PRESENT POSITION
     2008 to present Associate Professor of Biomedical Sciences
     Grand Valley State University
     Allendale, MI

PREVIOUS POSITIONS
     2004 to 2008 Assistant Professor of Biomedical Sciences
     Grand Valley State University
     Allendale, MI

       2002 to 2004 Assistant Professor of Biology
       St. Norbert College
       De Pere, WI

       2003 to 2004 Adjunct Biology Instructor
       Fox Valley Technical College
       Appleton, WI

       2002 Postdoctoral Fellow in Physiology
       Medical College of Wisconsin
       Milwaukee, WI
       Mentor: David L. Mattson, Ph.D.

       2001 to 2002 Biology Instructor
       University of Wisconsin-Waukesha
       Waukesha, WI

EDUCATION
     2002 Doctor of Philosophy in Physiology
     Medical College of Wisconsin
     Milwaukee, WI
     Advisor: Julian H. Lombard, Ph.D.

       1997 Master of Arts in Biology
       Drake University
       Des Moines, IA

       1993 Bachelor of Science in Animal Science
       Cornell University
       Ithaca, NY
PROFESSIONAL AFFILIATIONS
     2005 Council on Undergraduate Research

       2000 to 2006 Microcirculatory Society

       1999 to 2002 Society for Experimental Biology and Medicine

       1997 to present American Physiological Society

ACADEMIC AWARDS

       2008 Faculty Who Make a Difference Nominee, Faculty Fellows Committee-Department
       of Housing and Residence Life, Grand Valley State University

       2003 Nominee for the Educator of the Year Award, St. Norbert College

       2003 APS Teaching of Physiology Section Travel Award, Experimental Biology

       2002 Honorary Member of Omega Alpha Chapter of Beta Beta Beta Biological
       Honor Society, St. Norbert College

       2000 New Investigator Award, Jackson Cardiovascular-Renal Meeting

       1997 to 2001 Graduate Fellowship, Medical College of Wisconsin

       1997 Frances Rogers Student Honor Lecture Award, Drake University

       1995 to 1997 Teaching Assistantship, Drake University

       1989 Consalo Memorial Agricultural Scholarship, Cornell University

INVITED REVIEWERSHIP
      2002 American Journal of Physiology

       2001 Microcirculation

       2006 to present Vascular Pharmacology

TEACHING EXPERIENCE
     Undergraduate:
     2004 to present Grand Valley State University
     Advanced Human Physiology, Anatomy and Physiology (lab), Biology of Aging,
     Concepts in Wellness, Human Anatomy, Human Physiology, Introduction to Research in
     the Biomedical Sciences, Lab in Human Anatomy, and Lab in Human Physiology
     Responsibilities: Course Director

       2002 to 2004 St. Norbert College
       Human Biology, General Biology, Issues in World Technology, Systemic
       Physiology, and Endocrinology
       Responsibilities: Course Director
       2003 to 2004 Fox Valley Technical College
       Anatomy and Physiology and Human Nutrition
       Responsibilities: Course Director

       2001 to 2002 University of Wisconsin-Waukesha
       Human Anatomy and Physiology (for science majors and non-science majors) and
       Genetics
       Responsibilities: Course Director

       1995 to 1997 Drake University
       Biology
       Responsibilities: Laboratory Instructor

       1992 Cornell University
       Meat Science
       Responsibilities: Teaching Assistant

       Graduate/Medical:
       1999 to 2002 Medical College of Wisconsin
       Human Physiology
       Responsibilities: Laboratory Instructor/Tutor

       Other:
       1997 to 2001 La Farge Lifelong Learning Institute
       Human Physiology/Pathophysiology
       Responsibilities: Course Director for seminar series

GRANTS
     Extramural
     2006 Undergraduate Summer Research Fellowship (American Physiological
     Society) Benjamin Eovaldi, co-author, funds to support undergraduate research on
     the androgen signal transduction pathway in coronary and pulmonary arteries
     ($4,300), submitted application - not funded

       2004 Undergraduate Summer Research Fellowship (American Physiological Society)
       Candice Leach, co-author, funds to support undergraduate research on the effects of
       androstenedione on the microcirculation ($4,300), submitted application - not funded

       Intramural
       2009 Request for Special Project Graduate Assistantship (Grand Valley State University)
       Support for employing a graduate student to conduct physiological experiments in my
       laboratory.

       2008 Graduate Student Presidential Research Grant-in-Aid (Grand Valley State
       University)
       Kanchan Tiwari, co-author, funds to support graduate research on the modifications of
       coronary vascular reactivity due to oxidative stress ($831)

       2008 Pew FTLC Grant (Grand Valley State University)
       Support for attending Experimental Biology 2008 ($430)

       2008 Scholarly Travel Grant-in-Aid (Grand Valley State University)
       Support for presenting an abstract at Experimental Biology 2008 ($500)
2008 Research Grant-in-Aid (Grand Valley State University)
Brian Kipp, John Bender, John Capodilupo, and Mary Craig, co-authors, funds to support
research on physiological and morphological alterations in coronary arteries as a result of
oxidative stress ($3,000)

2007 Scholarly Travel Grant-in-Aid (Grand Valley State University)
Support for presenting an abstract at Experimental Biology 2007 ($500)

2007 Ronald E. McNair Scholars Program (Grand Valley State University)
James Dells, co-author, funds to support undergraduate research on the acute effects of
androgens on vascular reactivity in the microcirculation ($2,000)

2007 Research Grant-in-Aid (Grand Valley State University)
Brian Kipp, co-author, funds to support research on the possible mechanism of oxidative
damage resulting in impaired arterial function ($2,378)

2006 Student Summer Scholars (Grand Valley State University)
Benjamin Eovaldi, co-author, funds to support undergraduate research on the
androgen signal transduction pathway in coronary and pulmonary arteries
($6,000)

2006 Scholarly Travel Grant-in-Aid (Grand Valley State University)
Support for presenting an abstract at Experimental Biology 2006 ($500)

2005 Student Summer Scholars (Grand Valley State University)
Timothy Trichler, co-author, funds to support undergraduate research on the acute
responses of pulmonary and coronary arteries to natural steroids ($6,000)

2004 Faculty Development Fund (St. Norbert College)
Support for presenting an abstract at Experimental Biology 2004 ($500)

2003 Student-Faculty Development Endowment (St. Norbert College)
Amanda Miller and Patricia Rankin, co-authors, funds to support undergraduate
research on the effects of androstenedione on vascular function ($1,000)

2003 Kresge Science Endowment (St. Norbert College)
Funds to purchase equipment for an isolated microvessel setup ($6,000)

2003 Research Fellows Program (St. Norbert College)
Funds to support undergraduate research on the effects of animal- and plant-derived
proteins and lipids on blood vessel function ($1,000)

2003 Faculty Development Fund (St. Norbert College)
Support for presenting an abstract at Experimental Biology 2003 ($500)

2002 Kresge Science Endowment (St. Norbert College)
Funds to purchase equipment for an undergraduate physiology laboratory course
($13,080)

2002 Student–Faculty Development Endowment (St. Norbert College)
Laura Richards, co-author, funds to support undergraduate research on the effects
of paper mill effluent on blood vessel function ($1,000)
PUBLICATIONS
A. Theses:

1. F.A. Sylvester. L-NAME-induced hypertension in the WKY and BHR rat. M.A. Thesis. Drake
University, 1997.

2. F.A. Sylvester. Effects of high salt diet on mechanisms of acetylcholine-induced dilation of
cerebral resistance arteries. Ph.D. Dissertation. Medical College of Wisconsin, 2002.

B. Manuscripts:

1. F.A. Sylvester, J.C. Frisbee, and J.H. Lombard. Longitudinal differences in vascular control
mechanisms in isolated resistance arteries of the rat cremaster muscle. Microvasc. Res. 60:160-
167, 2000.

2. J.C. Frisbee, F.A. Sylvester, and J.H. Lombard. Contribution of extrinsic factors and intrinsic
vascular alterations to reduced arteriolar reactivity with high salt diet and hypertension.
Microcirculation. 7:281-289, 2000.

3. J.C. Frisbee, F.A. Sylvester, and J.H. Lombard. High-salt diet impairs hypoxia-induced cAMP
production and hyperpolarization in rat skeletal muscle arteries. Am. J. Physiol. 281:H1808-
H1815, 2001.

4. F.A. Sylvester, D.W. Stepp, J.C. Frisbee, and J.H. Lombard. High-salt diet depresses
acetylcholine reactivity proximal to NOS activation in cerebral arteries. Am. J. Physiol.
283:H353-H363, 2002.

5. J.H. Lombard, F.A. Sylvester, S.A. Phillips, and J.C. Frisbee. High-salt diet impairs vascular
relaxation mechanisms in rat middle cerebral arteries. Am. J. Physiol. 284:H1124-H1133, 2003.

6. S.A. Phillips, F.A. Sylvester, and J.C. Frisbee. Oxidant stress and constrictor reactivity impair
cerebral artery dilation in obese Zucker rats. Am. J. Physiol. 288:R522-530, 2005.

C. Abstracts:

1. F.A. Sylvester, D.B. Stratton, and R.J. Morrow. L-NAME-induced hypertension in the WKY
and BHR rat. FASEB J. 11:A40, 1997.

2. D.B. Stratton, R.J. Morrow, and F.A. Sylvester. Genistein prevents hypertension in male and
oophorectomized female SHR. FASEB J. 11: A467, 1997.

3. F.A. Sylvester and J.H. Lombard. Vascular control mechanisms differ within the cremaster
muscle arteriole network. FASEB J. 13:A30, 1999.

4. D.S. Weber, F.A. Sylvester, and J.H. Lombard. Role of angiotensin II and angiotensin receptor
subtypes in the maintenance of vasodilator reactivity in skeletal muscle resistance arteries during
elevated salt intake. FASEB J. 13:A88, 1999.

5. J.H. Lombard, F.A. Sylvester, and D.S. Weber. Role of angiotensin II (Ang II) suppression and
AT1 Ang II receptors in modulating vasodilation responses in middle cerebral arteries of rats on
high salt diet. FASEB J. 14:A94, 2000.
6. J.C. Frisbee, F.A. Sylvester, and J.H. Lombard. Contribution of extrinsic factors and intrinsic
vascular alterations to reduced arteriolar dilation during high salt diet and hypertension. FASEB
J. 14:A94, 2000.

7. F.A. Sylvester, D.W. Stepp, J.C. Frisbee, and J.H. Lombard. Impaired dilation to acetylcholine
in cerebral arteries from rats on high salt diet is not due to inactivation of nitric oxide. FASEB J.
15:A50, 2001.

8. F.A. Sylvester, J.C. Frisbee, R.J. Roman, J.R. Falck, and J.H. Lombard. The effect of acute
high salt diet on mediators of acetylcholine reactivity in rat middle cerebral artery. FASEB J.
15:A122, 2001.

9. J.H. Lombard, J.C. Frisbee, F.A. Sylvester, T. Huang, and Y. Liu. Role of intrinsic alterations
in vascular smooth muscle cells (VSMC) in contributing to impaired relaxation of middle
cerebral arteries (MCA) to reduced PO2 during elevated salt intake. FASEB J. 15:A103, 2001.

10. J.C. Frisbee, F.A. Sylvester, and J.H. Lombard. High salt diet impairs vascular smooth muscle
cell signaling in response to hypoxia and prostacyclin in skeletal muscle resistance arteries.
FASEB J. 15:A50, 2001.

11. J.C. Frisbee, F.A. Sylvester, D.W. Jones, and D.W. Stepp. Altered passive mechanics of
skeletal muscle resistance arteries of obese Zucker rats. FASEB J. 15:A40, 2001.

12. F.A. Sylvester, S.A. Phillips, J.C. Frisbee, J.H. Lombard. AT1 and AT2 receptors mediate the
restorative effect of angiotensin II on acetylcholine reactivity in cerebral arteries of rats on high
salt diet. FASEB J. 16:A127, 2002.

13. F.A. Sylvester, J.C. Frisbee, and J.H. Lombard. Short-term high salt diet depresses
acetylcholine reactivity proximal to NO synthase activation in cerebral arteries. FASEB J.
16:A128, 2002.

14. J.H. Lombard, F.A. Sylvester, S.A. Phillips, J.C. Frisbee. Thromboxane A2 (TXA2) release
and impaired G-protein coupling contribute to loss of hypoxic dilation in middle cerebral arteries
(MCA) of rats on high salt (HS) diet. FASEB J. 16:A78-A79, 2002.

15. F.A. Sylvester, J.C. Frisbee. Introducing human biology students to the scientific process.
FASEB J. 17, 2003.

16. F.A. Sylvester, C.M. Palid, and A.M. Meulemans. The effect of consuming Fox River water
containing papermill effluent on cardiovascular function. FASEB J. 18, 2004.

17. S.A. Phillips, F.A. Sylvester, J.C. Frisbee. Oxidant stress and constrictor reactivity impair
cerebral artery dilation in obese Zucker rats. FASEB J. 19, 2005.

18. J.H. Lombard, M.W. Buelow, K.T. Behm, S.A. Phillips, and F.A. Sylvester. High salt diet
and angiotensin II AT1 receptor blockade depress intestinal contractile responses to acetylcholine
in normotensive rats. FASEB J. 19, 2005.

19. T.R. Trichler, A. Jedd, and F.A. Sylvester. The acute responses of coronary and pulmonary
arteries to natural steroids. FASEB J. 20, 2006.

20. B. Eovaldi and F.A. Sylvester. The effect of dihydrotestosterone on vascular reactivity in
coronary and pulmonary arteries. FASEB J. 21, 2007.
21. F.A. Sylvester, J. Hall, A. Hallack, and B. Kipp. The effect of superoxide generation by
ascorbic acid and imidazole on coronary and pulmonary arteries. FASEB J. 22, 2008.

RESEARCH STUDENT PRESENTATIONS

1. F.A. Sylvester, C.M. Palid, and A.M. Meulemans. The effect of consuming Fox River water
containing papermill effluent on cardiovascular function. Experimental Biology 2004,
Washington, DC.

2. Anthony Jedd. The acute effect of dehydroepiandrosterone (DHEA) on blood vessels. Student
Scholarship Day 2005, Grand Valley State University, Allendale, MI.

3. T.R. Trichler. The acute responses of coronary and pulmonary arteries to natural steroids.
Student Summer Scholars Presentations 2005, Grand Valley State University, Allendale, MI.

4. T.R. Trichler, A. Jedd, and F.A. Sylvester. The acute responses of coronary and pulmonary
arteries to natural steroids. Experimental Biology 2006, San Francisco, CA.

5. B. Eovaldi. The effect of prolonged incubation with dihydrotestosterone on coronary and
pulmonary arteries. Student Summer Scholars Presentations 2006, Grand Valley State University,
Allendale, MI.

6. B. Eovaldi. The effect of prolonged incubation with dihydrotestosterone on coronary and
pulmonary arteries. Student Scholarship Day 2007, Grand Valley State University, Allendale, MI;
Experimental Biology 2007, Washington, DC.

7. E. Bechtel, J. McKee, and D. Yousef. The effect of 4-hour incubation with dihydrotestosterone
on coronary arteries and responses of coronary arteries to imidazole and ascorbic acid. Student
Scholarship Day 2007, Grand Valley State University, Allendale, MI.

8. E. Bechtel. The effect of prolonged incubation with dihydrotestosterone on coronary arteries.
Student Scholarship Day 2008, Grand Valley State University, Allendale, MI.

9. O. Hirekahn and D. Majkszak. The effects of androgens on coronary arteries. Student
Scholarship Day 2008, Grand Valley State University, Allendale, MI.

10. E. Stir. Free radical damage on coronary arteries. Student Scholarship Day 2008, Grand
Valley State University, Allendale, MI.

11. P. Dakwale. The acute effect of testosterone on the renal vasculature. Student Scholarship
Day 2009, Grand Valley State University, Allendale, MI.

12. K. Tiwari. Modifications of coronary vascular reactivity due to oxidative stress. Student
Scholarship Day 2009, Grand Valley State University, Allendale, MI.

13. E. Caverly. Anterior cruciate ligament reconstruction: autograft or allograft. Student
Scholarship Day 2009, Grand Valley State University, Allendale, MI.

14. Z. Heathman, D. Banda, A. Bosch, and O. Hirekhan. The acute effects of histamine, histidine,
and vitamin C on the vascular reactivity of coronary arteries. Student Scholarship Day 2009,
Grand Valley State University, Allendale, MI.
PRESENTATIONS/SEMINARS

1. “L-NAME-induced hypertension in the WKY and BHR rat”
Drake University, Des Moines, IA; 1997.
Midwest Physiological Society, Medical College of Wisconsin, Milwaukee, WI; 1997.

2. “Vasoconstrictor and vasodilator responses of the cremasteric arterial network”
Medical College of Wisconsin, Milwaukee, WI; 1998.

3. “Regulation of the cremaster muscle arterial network”
Medical College of Wisconsin, Milwaukee, WI; 1999.

4. “Vascular control mechanisms differ within the cremaster muscle arteriole network”
Midwest Physiological Society, University of Wisconsin, Madison, WI; 1999.

5. “Acute high salt diet attenuates acetylcholine-induced dilation but not receptor independent
NO release or NO sensitivity in the middle cerebral artery (MCA) of normotensive rats”
Experimental Biology, San Diego, CA; 2000.
Midwest Physiological Society, University of Chicago Medical School, Chicago, IL; 2000.

6. “Acute high salt diet and vascular reactivity in the cerebral circulation”
Medical College of Wisconsin, Milwaukee, WI; 2000.

7. “Attenuated acetylcholine-induced vasodilation in middle cerebral arteries from animals on
high salt diets is not due to inactivation of nitric oxide by superoxide”
Jackson Cardiovascular-Renal Meeting 2000, University of Mississippi Medical Center, Jackson,
MS; 2000.

8. “High salt, nitric oxide, and brain blood flow”
St. Mary’s University, Winona, MN; 2001.

9. “Mechanisms of blood flow regulation”
University of Wisconsin-Green Bay, Green Bay, WI; 2001.

10. “Reabsorption in the kidney”
Marian College, Fond du Lac, WI; 2001.

11. “Angiotensin II restores acetylcholine reactivity in cerebral arteries of rats on high salt diet”
Midwest Physiological Society, University of Wisconsin, Madison, WI; 2001.

12. “Introduction to renal physiology”
University of Wisconsin-Waukesha, Waukesha, WI; 2001.

13. “Effects of high salt diet on mechanisms of acetylcholine-induced dilation of cerebral
resistance arteries”
Medical College of Wisconsin, Milwaukee, WI; 2001.

14. “Muscle contraction: getting from here to there”
“A little salt goes a long way in the brain”
St. Norbert College, De Pere, WI; 2002.

15. “The effect of diet on vascular function”
St. Norbert College, De Pere, WI; 2002.
16. “Hormones - a means of communication”
College of Wooster, Wooster, OH; 2004

17. “The effect of Fox River water containing papermill effluent on blood vessel function”
Grand Valley State University, Allendale, MI; 2004
Randolph-Macon College, Ashland, VA; 2004
St. Norbert College, De Pere, WI; 2003
Susquehanna University, Susquehanna, PA; 2004

18. “Male steroids and the circulatory system: the good, the bad, and the ugly”
Grand Valley State University, Allendale, MI; 2006

19. “Novel Mechanism for Studying the Effects of Free Radicals on Coronary Arteries”
Grand Valley State University, Allendale, MI; 2008

				
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