APPLICATION FOR MEDICAL STUDENT RESEARCH FELLOWSHIP - SUMMER 2004

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APPLICATION FOR MEDICAL STUDENT RESEARCH FELLOWSHIP - SUMMER 2004 Powered By Docstoc
					                                      Mentor Application
             DEAN'S SUMMER STUDENT RESEARCH FELLOWSHIP- Spring 2010
                              SCHOOL OF MEDICINE

    Please submit completed applications to Jerry Clark in the School of Medicine (N145) or electronically at
   jclark@union.umsmed.edu by January 4, 2010. If you would like to have your application available to
            students before the winter holiday, please submit it no later than December 17, 2009.

Project Title: Impact of maternal diabetes on the development of diabetes and renal disease in adulthood of the offspring

Mentor Name: Christine Maric
      Email: cmaric@physiology.umsmed.edu
      Phone number: 601-984-1818
      Department: 601-984-1817

Number of Students Previously Supervised:
Post-Graduate Fellow Mentoring
2002-2005            Faizah Bhati, MD., (Pediatrician, Hershey, PA)
Oct 2007-Apr 2008 Xu Zhao, Post-doc Fellow, Georgetown University
Apr 2007-Apr 2008 Shannon Sullivan, MD., Resident, Department of Medicine, Division of Endocrinology and
                     Metabolism, Georgetown University
Jun 2008-present     Sun Mu, MD, PhD. E-mentoring via, University of Minnesota
Sep 2008-present     Michaele Manigrasso, MD., Post-doc Fellow, Dept of Physiology and Biophysics, UMMC

Doctoral Student Mentoring
Jun 2005-Sep 2009 Joseph Garman “Dietary antioxidants in the pathophysiology of diabetic kidney disease”

Doctoral Student Committees
2004-2006     Lydia Kuo “Neurovascular remodelling of adipose tissue via Neuropeptide Y” Department of
                     Physiology and Biophysics Georgetown University
2004-2008     Jennifer Rogers “Effects of sex hormones in the kidney” Department of Physiology and Biophysics,
                     Georgetown University

Graduate Student (Rotations) Mentoring
Oct 2003-Sep 2004 Sara Paiva, Department of Physiology and Biophysics, Georgetown University
Aug 2004-Nov 2004 Sara Iskikian, Department of Physiology and Biophysics, Georgetown University
Jul 2009             Peter Mittwede, Department of Physiology and Biophysics, UMMC
Jul 2009             Emily Gilbert, Department of Physiology and Biophysics, UMMC
Aug 2009             Matthew Dukes, Department of Physiology and Biophysics, UMMC
Sep 2009             Jeremy Freeman, Department of Physiology and Biophysics, UMMC

Undergraduate Thesis Student Mentoring
2002-2003    Peter Lin (1st year Medical Student). Mini project on “Angiotensin in diabetic nephropathy”
2002-2003    Garrett Fitzgerald (3rd year Science undergraduate senior thesis,) “The Protective role of estrogen
                     in diabetic renal disease” Department of Biology
2002-2003    Caitlin Enright (3rd year Science undergraduate senior thesis) “The Role of angiotensin II and
                     estrogen in the regulation of renomedullary interstitial cell growth” Department of Biology
Visiting Scholars Mentoring
1999-2000             Viktoria Göransson (visiting PhD student from University of Uppsala, Sweden)
Aug-Dec 2005          Louise Rügheimer (PhD student from the University of Uppsala, Sweden)

Graduate Student Advisor (Georgetown University)
2002 Advisor (4 students), Special Master Student Program, Dept. of Physiology and Biophysics
2003 Advisor (10 students), Special Master Student Program, Dept. of Physiology and Biophysics
2004 Advisor (11 students), Special Master Student Program, Dept. of Physiology and Biophysics 2005 Advisor (14
students), Special Master Student Program, Dept. of Physiology and Biophysics
2006 Advisor (14 students), Special Master Student Program, Dept. of Physiology and Biophysics

Summer Student Mentoring
Jul-Aug 2002       Phillipa Davis (Society for Experimental Biology and Medicine summer student)
Jul-Aug 2002       Lucy Jickling (American Heart Association Summer student)
Jul-Aug 2003       Loui Zhang (American Heart Association Summer student)
Jul-Aug 2003       Seema Kacker
Jul-Aug 2004       Nida Zulfiqar
May-Aug 2006       Sandhya Singh
Jun-Aug 2006       Sheena Chaundray
Jun-Aug 2007       Sandhya Singh
Jun-Aug 2007       Sujata Singh
May 2008-May 2009 Moumita Biswas (SURE Program, UMMC)
Jun-Aug 2009       Lauren Roach (NIH/NIDDK STEP-UP summer intern program)
Jun-Aug 2009       Deani Haggerty (SURE Program, UMMC)

Supervised Student Productivity:
    Number of Student Papers:
   1. Göransson V, Hansell P, Moss S, Alcorn D, Johnsson C, Hällgren R and Maric C. Renomedullary interstitial
       cells in culture: the osmolality and oxygen tension influence the extracellular amounts of hyaluronan and
       cellular expression of CD44. Matrix Biology 20: 137-146, 2001.
   2. Bhatti F, Mankhey RW, Asico L, Quinn MT, Welch W, Maric C. Mechanisms of antioxidant                     and pro-
       oxidant effects of -Lipoic acid in the diabetic and non-diabetic kidney. Kidney Int 67:        1371-1380, 2005.
   3. Mankhey RW, Bhatti F, Maric C. 17-β estradiol replacement improves renal function and pathology
       associated with diabetic nephropathy. AJP-Renal Physiol 288: 399-400,         2005.
   4. Wells CC, Riazi S, Mankhey RW, Bhatti F, Ecelbarger C, Maric C. Diabetic nephropathy is                  associated
       with decreased circulating estradiol levels and imbalance in the expression of         renal estrogen receptors.
       Gender Medicine 2: 237-247, 2005.
   5. Mankhey RW, Wells CC, Bhatti F, Maric C. 17-estradiol supplementation reduces tubulointerstitial fibrosis
       by increasing MMP activity in the diabetic kidney. AJP-Reg Integ Comp Physiol          292: R769-R777, 2007.
   6. Rogers JL, Mitchell AR, Maric C, Sandberg K, Myers A, Mulroney SE. Effects of sex                hormones onrenal
       estrogen and angiotensin II AT 1 receptors (AT1R) in female and male rats. AJP-Reg Integ Comp Physiol
       292: R794-R799, 2007.
   7. Dixon A, Wells CC, Singh S, Babayan R, Maric C. Renoprotective effects of a selective estrogen receptor
       modulator raloxifene in an animal model of diabetic nephropathy. J Nephrol 27: 120-128, 2007.
   8. Xu Q, Wells CC, Garman JH, Asico L, Escano CS, Maric C. Imbalance in sex hormone levels exacerbates
       diabetic renal disease. Hypertension 51: 1218-1224, 2008.
   9. Rügheimer L, Johnsson C, Maric C, Hansell P. Hormonal regulation of renomedullary hyaluronan. Acta
       Physiol (Oxf) 193:191-198, 2008.
   10. Garman JH, Mulroney S, Flynn E, Manigrasso M, Maric C. Omega-3 fatty acid rich diet prevents diabetic renal
       disease. AJP-Renal Physiol 296:F306-F316, 2009.
   11. Xu Q, Prabhu A, Xu S, Manigrasso MB, Maric C. Dose-dependent effects of dihydrotestosterone in the
       streptozotocin-induced rat diabetic kidney. Am J Physiol: Renal Physiol 297: F307-F315, 2009.

     Number of Student Abstracts: Total of 36, titles not listed
     Number of Student Presentations:
Poster Presentations at National Scientific Conferences by Students and Fellows
2004 Bhatti F, Mankhey R, Welch W, Maric C. Treatment with -lipoic acid reduces oxidative stress in diabetic
       nephropathy. Annual Scientific Meeting of the FASEB
2004 Mankhey R, Bhatti F, Maric C. Replacement with 17β-estradiol increases Matrix Metalloproteinase expression in
       diabetic nephropathy. Annual Scientific Meeting of the FASEB
2004 Bhatti F, Mankhey R, Welch W, Maric C. Alpha-lipoic acid attenuates diabetic nephropathy but causes renal
       dysfunction and morphological damage in the non-diabetic kidney. 58th Annual Meeting of the High Blood
       Pressure Research Council
2004 Bhatti F, Tomaszewski M, Zkrewski J, Szakiel K, Paszteleniec R, Zukowska-Scszekowska, Sandberg K,
       Grzeszczak W, Maric C. Sexual dimorphism in tubulointerstitial fibrosis associated with hypertensive
       nephropathy in humans. J Am Soc Nephrol 15: pp. 120A
2005 Iskikian SO, Bhatti F, Maric C. Anti-inflammatory and antioxidant effects of 17-estradiol in Diabetic
       Nephropathy. International Symposium on the science of diabetes complications” Implications for Novel
       therapy
2007 Garman JH, Dixon A, Maric C. Protective effects of omega-3 fatty acids in an animal model of diabetic
       nephropathy. Annual Scientific Meeting of the FASEB
2007 Rogers JL, Mitchell AR, Maric C, Myers, AK, Zukowska Z, Mulroney SE. Growth Hormone regulation of NPY in
       the diabetic kidney. Annual Scientific Meeting of the FASEB

Oral Presentations at National Scientific Conferences by Students and Fellows
2006 Garman JH, Dixon A, Maric C. Protective effects of omega-3 fatty acids in an animal model of diabetic
       nephropathy. Society for Experimental Biology and Medicine (DC Chapter) Student Research Symposium

Oral/Poster Presentations at University level by Students and Fellows
2006 Rogers JL, Mitchell AR, Maric C, Mulroney SE. Growth Hormone (GH) Replacement in Streptozotocin (STZ)
       Diabetic Rats: A New Model of Human Diabetes. Student Research day, Georgetown University
2007 Garman JH, Dixon A, Maric C. Protective effects of omega-3 fatty acids in an animal model of diabetic
       nephropathy. Student Research day, Georgetown University
2008 Moumita Biswas, Effects of testosterone in the kidney after high salt treatment. SURE Program Student
       Presentations, UMMC
2009 Lauren Roach, Effects of testosterone in the kidney after high salt treatment. Department of Physiology and
       Biophysics Summer Student Presentations, UMMC
2009 Deani Haggerty, Long-term effects of gestational diabetes in the offspring. SURE Program Student
       Presentations, UMMC

Awards Received by Graduate Students and Fellows
2004 Faizah Bhatti (Post-Graduate Fellow), Fellow Travel Award to the American Society of Nephrology Annual
      Scientific Meeting, San Diego, CA
2004 Sara Iskikian (Graduate student (rotation)), Student Travel Award to the Endocrinology Canada meeting on
      Diabetic Renal Complications, Toronto, Canada
2006 Joseph Garman (PhD candidate), 2nd place, Society for Experimental Biology and Medicine Student
      Research Forum
2007 Joseph Garman (PhD candidate), Winner, Student Research day, Georgetown University
2009 Joseph Garman (PhD candidate), Runner-up, Student Research day, Georgetown University
Funding Source for Work: NIH/NIDDK

Would you be able to support a summer student’s salary without the Dean’s Grant?                                         YES

IRB Approval (Clinical Research) Obtained:                       N/A

IACUC Approval (Research with Animals) Obtained: YES

Briefly describe your project so the student can clearly understand the work that will be undertaken and the rationale for doing the research. Do not exceed
these two pages. You should have the laboratory or clinical resources to support the proposed work. The project should have a reasonable chance of producing
tangible results during the 10-week length of the fellowship.

Statement of Problem and Background:

Population-based studies have shown that the offspring of diabetic mothers have an increased risk of
developing obesity, insulin resistance, type 2 diabetes, hypertension, cardiovascular and renal disease later in
life. However, the mechanisms leading to this increased risk are not understood.
        The aim of this study is to examine the consequence of exposure to hyperglycemia during gestation on
the development of insulin resistance and renal disease in the offspring.

Methods and Data Analysis:


The study will use two different model of maternal diabetes: a) Non-obese: the streptozotocin-induced
diabetic model and 2) Obese: diet-induced diabetic model. Following birth, the offspring will be followed for up
to 8 months after birth and their body weights, blood glucose, blood pressure and renal function monitored
monthly for the entire experimental period. Following the treatment period, the animal will be sacrificed and the
kidney analyzed for markers of renal injury.

Anticipated Outcome(s):


We predict that the offspring born to diabetic mothers will develop insulin resistance and mild glucose
intolerance after around 10 weeks. At around 4 months of age, we predict that the offspring will develop signs
of renal dysfunction, characterized by microalbuminuria.

Significance of the Work:


Rates of diabetes and obesity have increased exponentially worldwide to almost epidemic proportions. This is
associated with a marked increase in adverse maternal and perinatal outcomes and subsequent burden on
health care resources. Maternal diabetes is associated with long-term health consequences for the offspring.
However, the underlying pathophysiology linking maternal diabetes and offspring disease in adulthood are
unknown. Studying these mechanisms may lead to better understanding of whether alteration of maternal
lifestyle can improve maternal and fetal outcomes.