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Ergebnis normalisiert

VIEWS: 90 PAGES: 873

  • pg 1
									tf_name
AFP1
AhR
aMEF-2
AML1
AML1a
AML1b
AML1c
AML2
AML3
AML3a
AML3b
AP-1
AP-4
AR
AREB6
Arnt
ARP-1
ATF
ATF-1
ATF3
ATF4
ATF4 (381AA)
ATF6
Bach1
Bach2
C/EBP
C/EBPalpha
C/EBPdelta
C/EBPgamma
CACCC-binding factor
CAR
CAR:RXR-alpha
Cart-1
CBF(2)
CBF-A
CBF-B
CBF-C
Cdc5
Cdx-2
Cdx-3
c-Ets-1
c-Ets-1 54
c-Ets-1 68
c-Ets-2
CHOP-10
Chx10
c-Jun
Clox
c-Myb
COMP1
core-binding factor
COUP
COUP-TF
COUP-TF1
CP1
CP1A
CP1C
CP2
CREB
CREBbeta
CRE-BP1
c-Rel
CREMalpha
CREMbeta
CREMgamma
CREMtau
CREMtau1
CREMtau2
CREMtaualpha
CUTL1
delta factor
deltaCREB
DP-1
E12
E2
E2F
E2F+E4
E2F-1
E2F-1:DP-1
E2F-1:DP-2
E2F-2
E2F-3
E2F-4
E2F-4:DP-1
E2F-4:DP-2
E2F-5
E47
E4BP4
E4F1
EGR1
Egr-1
EGR2
EGR3
ELF-1
Elf-1
ER-alpha
ER-beta
ER-beta1
Evi-1
FOR1
FOR2
FOXA4a
FOXC1
FOXC2
FOXD1
FOXD3
FOXE1
FOXF1
FOXF2
FOXH2
FOXI1
FOXI1a
FOXJ1
FOXJ1a
FOXJ1b
FOXJ2
FOXK1a
FOXL1
FOXM1a
FOXM1b
FOXN1
FOXN2
FOXO1
FOXO1a
FOXO3
FOXO3a
FOXO3b
FOXO4
FXR
FXR:RXR-alpha
FXR-alpha
GABP
GABP-alpha
GABP-beta1
GABP-beta2
GADD 153
GATA-1
GATA-1A
GATA-2
GATA-3
GATA-4
GCMa
GCMb
GCNF
GCNF-1
GCNF-2
Gfi-1
GR
GR-alpha
Hand1
HEB
HEN1
HFH-1
HFH-3
HIF-1
Hlf
Hmx3
HNF-1
HNF-1A
HNF-1B
HNF-1C
HNF-3alpha
HNF-3B
HNF-3beta
HNF-4
HNF-4alpha
HNF-4alpha1
HNF-4alpha2
HNF-4alpha3
HNF-4alpha4
HNF-4alpha7
HNF-4gamma
HNF-6alpha
HNF-6beta
HOXA5
HOXA9
HOXA9a
HOXA9B
HP1 site factor
HSF
HTF
ICSBP
Ik-1
Ik-3
IPF1
IRF-10
IRF-2
IRF-3
IRF-4
IRF-5
IRF-6
IRF-7
IRF-7A
IRF-7H
ISGF-3
ITF-2
Krox-20
Krox-24
LCR-F1
LEF-1
Lhx3a
Lhx3b
Lmo2
LXR-alpha
LXR-alpha:RXR-alpha
LXR-beta
LXR-beta:RXR-alpha
MAF
MafG
Max
Max1
Max2
MAZ
MAZR
MEF-2
MEF-2C
MEF-2DAB
Meis-1
Meis-1a
Meis-1b
MIF-1
MRF4
MTF-1
MyoD
myogenin
NERF-1a
NF-1
NF-1/L
NF-1/Red1
NF-1A1
NF-1B1
NF-1B2
NF-1C2
NF-1X
NF-A
NF-E2
NF-E2 p45
NF-EM5
NF-kappaB
NF-kappaB1
NF-kappaB1 precursor
NF-kappaB2
NF-kappaB2 (p49)
NF-kappaB2 precursor
NF-muE1
NF-TNF
NF-Y
NF-YA
NF-YB
NF-YC
NGFI-C
Nkx2-2
Nkx2-5
NKX2B
Nkx3-1
NKX3A
NKX3A v1
NKX3A v2
NKX3A v3
NKX3A v4
Nkx6-1
NKX6A
N-Myc
NRF-1
Nrf2
Nrf2:MafK
Nrf2:MafK
oct-B2
oct-B3
Olf-1
Pax-1
Pax-2
Pax-2a
Pax-3
Pax-4a
Pax-4c
Pax-5
Pax-6
Pax-8
Pax-9a
Pax-9b
Pbx-1a
PEBP2
PEBP2alphaA
PEBP2alphaA1
PEBP2alphaA2
PEBP2alphaB1
PEBP2alphaB2
Pitx2
POU1F1
POU2F1a
POU2F1b
POU2F1c
POU2F2
POU2F2B
POU2F2C
POU3F2
POU6F1 (c2)
PPAR-alpha
PPAR-gamma
PPAR-gamma1
PPAR-gamma2
PR
PTF1-beta
PXR-1
PXR-1:RXR-alpha
PXR-1:RXR-beta
PXR-2
PXR-2:RXR-alpha
R
RAR-alpha
RAR-alpha:RXR-alpha
RAR-alpha:RXR-gamma
RAR-alpha1
RAR-beta
RAR-gamma
Rb:E2F-1:DP-1
RelA
RFX1
RORalpha1
RORalpha2
RREB-1
RSRFC4
RXR-alpha
RXR-beta
S8
SF-1
SMAD-3
SMAD-4
Sox-5
SOX-9
Sp3
SREBP-1
SREBP-1a
SREBP-1b
SREBP-1c
SREBP-2
SRF
SRF (263 AA)
SRF (400 AA)
SRF (440 AA)
SRF (504 AA)
Staf
STAT1
STAT1alpha
STAT1beta
STAT2
STAT3
STAT4
STAT5A
STAT5B
STAT6
SXR:RXR-alpha
Tal-1
Tal-1beta
Tax
TBP
TBP
TCF-1(P)
TCF-4
TEF
Tel-2a
Tel-2b
Tel-2c
TFIIA
TFIIA-alpha/beta precursor (ma
TFIIA-gamma
TFIIB
TFIID
TFII-I
TGIF
TTF-1
USF
USF-1
USF-1:USF-2
USF2
VBP
VDR
v-ErbA
vHNF-1
vHNF-1A
vHNF-1B
vHNF-1C
v-Jun
v-Maf
Vmw65
v-Myb
XBP-1
Xvent-1
YAP1
YY1
ZID
Zta
tf_synonyms
AFP-1, alpha fetoprotein enhancer binding protein.
AhR, Ah receptor, dioxin receptor, XRE-binding factor, aryl hydrocarbon receptor.
aMEF2.
AML1, PEBP2alphaB, Acute myeloid leukemia 1 protein, Core-binding factor, alpha 2 subunit, RUNX1, CBF-alpha 2, Runt-rela
AML1, PEBP2alphaB, RUNX1, CBF-alpha 2.
AML1, PEBP2alphaB, PEBP2alphaB1, RUNX1, CBF-alpha 2.
AML1, PEBP2alphaB, AML-1B, RUNX1, CBF-alpha 2.
AML2, PEBP2alphaC1, CBF-alpha 3, RUNX3, Runt-related transcription factor 3, Core-binding factor, alpha 3 subunit, Acute m
Osf2, PEBP2alphaA, AML3, PEBP2alphaA1, Polyomavirus enhancer binding protein 2 alpha A subunit, CBF-alpha 1, RUNX2,
PEBP2alpha1, Osf2, PEBP2alphaA, CBF-alpha 1, RUNX2.
PEBP2alpha1, Osf2, PEBP2alphaA, CBF-alpha 1, RUNX2.
(Jun)2, AP1, Fos/Jun, PEA1, PEA1 (mouse).
AP4.
androgen receptor, AR, NR3C4, dihydrotestosterone receptor.
Nil-2-a, TCF8 (gene name), AREB6, Atp1a1 Regulatory Element Binding protein 6, ZEB, zinc finger E-box-binding protein, neg
hypoxia-inducible factor 1beta, aryl hydrocarbon receptor nuclear translocator, HIF-1beta.
ARP-1, COUP-beta, apolipoprotein AI regulatory protein, NR2F2, COUP-TF II.
ATF.
ATF-1, TREB-36.
activating transcription factor 3, LRG-21.
ATF-4, CREB-2, TAXREB67 homolog, YAVREB67, TR67, C/ATF, mTR67, activating transcription factor 4.
ATF-4, CREB-2, TAXREB67 homolog, YAVREB67, TR67, C/ATF, mTR67, activating transcription factor 4.
activating transcription factor 6, cyclic-AMP-dependent transcription factor.
BTB and CNC homolog 1, transcription regulator protein BACH1.
BTB and CNC homolog 2.
BPc, CBP, C/EBP, C/EBPalpha, EBP20, CCAAT/enhancer binding protein alpha.
BPc, CBP, C/EBP, C/EBPalpha, EBP20, p42(C/EBPalpha), p42C/EBPalpha, C/EBPalpha(p42), CCAAT/enhancer binding prote
C/EBPdelta, CELF, CRP3, NF-IL6beta.
C/EBPgamma, GPE1-BP, Ig/EBP1, muEBP-E, Ig/EBP-1.
CACCC-binding factor, htbeta.
NR1I3, phenobarbital receptor, constitutive androstane receptor, MB67 (human).

cartilage homeoprotein 1.
CBF(2), CBF-A + CBF-B, CCAAT-binding factor, CP1, NF-Y (mouse), NF-YA:NF-YB:NF-YC.
CBF-A, CP1-A, HAP3 (yeast), NF-YB (mouse).
CBF-B, CP1-B, HAP2 (yeast), NF-YA (mouse).
NF-YC (mouse), CP1C (human).
PCDC5RP, Pombe Cdc5-related protein, cell division control protein 5.
CDX2, caudal homolog homeobox protein 2.
Cdx-2, shCdx-2.
c-Ets-1, Ets1, p54.
c-Ets-1, c-Ets-1 54, Ets1, p54, p54c-Ets-1.
c-Ets-1 68, p68c-Ets-1.
c-Ets-2, c-Ets-2 58-64, Ets2, p58-64c-Ets-2, Ets-2.
CHOP-10, GADD 153 (hamster).
HOX10, RET1, C. elegans ceh-10 homeo domain-containing homolog.
c-Jun, p39, JunA.
CDP, Cux.
c-Myb.

core-binding factor.
COUP, COUP-TF, chicken ovalbumin upstream promoter transcription factor.
COUP-TF, chicken ovalbumin upstream promoter transcription factor.
COUP, COUP-TF, EAR3, COUP-alpha, NR2F1, chicken ovalbumin upstream promoter transcription factor.
alpha-CP1, CBF, CP1, NF-Y, trimer NF-Y, NF-Y complex.
CBF-A (rat), CP1-A, HAP3 (yeast), NF-YB (mouse).
CBF-C (rat), NF-YC (mouse), HSM-1.
alpha-CP2a, alpha-CP2a, alpha-CP2b, CP-2, LSF, SEF-1, alpha-CP2, LBP-1c, SAA enhancer factor 1.
CREB, CREBalpha.

HB16, TREB-7, XBP-4, XBP4, ATF-2 (human), CREBP1.
c-Rel, HIVEN86A, p82(hc-rel), p68.
CREM-alpha.
CREMbeta.
CREMgamma.
CREMtau.
cAMP-responsive element modulator tau1.
cAMP-responsive element modulator tau2.

CDP, CCAAT displacement protein, cut homeodomain protein, Cux, cut-like homeodomain protein, Clox.
delta-factor, F-ACT1, NF-E1 (2), YY-1, YY1.
CREBdelta, deltaCREB.
DRTF1-polypeptide-1.
A7, E2A.
E2.

E2F+E4.
E2F.




a1, E47, shPan1 (hamster), E2A.
NF-IL3A.
E4F1, E4TF3, EIIA-EF.
ETR103, Krox-24, NGFI-A, zif268, Egr-1, early growth response protein 1, AT225.
EGR1, Krox-24, NGFI-A, TIS-8, zif268, early growth response protein 1.
Krox-20 (mouse), early growth response protein 2, AT591.
pilot, early growth response protein 3.
Elf-1.
E74-like factor 1, Elf1, ETS-related transcription factor ELF-1.
ER, estrogen receptor, NR3A1.
estrogen receptor beta, NR3A2, ESTRB, ESR2.
NR3A2, estrogen receptor beta 1.
Evi-1, ecotropic virus integration 1 site protein.
FXR-like orphan receptor, FXR-like orphan receptor 1, FOR, FOR-1, FOR 1.
FXR-like orphan receptor, FOR, FOR 2, FOR-2, FXR-like orphan receptor 2.
XFD-1, Pintallavis.
FREAC3, FKHL7.
Mesenchyme fork head 1, Fkh-14, Fork head homolog 14, MFH-1.
Forkhead RElated ACtivator-4, FKHL8, FREAC4.
HFH2, Genesis, HFH-2.
TTF-2.
HNF-3/Fkh Homolog 8, Freac-1 (Forkhead RElated ACtivator-1), HFH-8.
LUN.
forkhead activin signal transducer 2, FAST-2, FAST2.
Forkhead RElated ACtivator-6, FKHL10, HFH3, FREAC6, HFH-3 (HNF-3/Fkh Homolog 3), HFH-3.
Xenopus fork head domain factor 2, XFD2, XFD-2.
HNF-3/Fkh Homolog 4, HFH-4.
HNF-3/Fkh Homolog 4, FKHL13, HFH-4.

FHX.L, fork head homologous X, long isoform.
ILF-1, interleukin enhancer binding factor 1, ILF.
FKHL11, FREAC7.
HNF-3/Fkh Homolog 11A, FKHL16A, HFH-11A.
HFH-11B.
winged-helix nude, Whn.
HTLF, human T-cell leukemia virus enhancer factor.
FKHR.
ALV, FKHR, FKH1.
FKHRL1, FKHR2.
FKHRL1.
FKHRL1P1.
AFX, AFX-1, AFXH.
HRR1, NR1H4, retinoid X receptor interacting protein 14, farnesoid X activated receptor, RIP14, BAR, bile acid receptor, RIP-1

HRR1, NR1H4, retinoid X receptor interacting protein 14, farnesoid X activated receptor, RIP14, BAR, bile acid receptor, RIP-1
EF-1A, GABP, NRF-2, nuclear respiratory factor 1, GA binding protein, enhancer-binding factor to the E1A core motif.
GABP-alpha, NRF-2alpha, GA binding protein alpha subunit.
E4TF1-53, GA binding protein beta1 subunit, NRF-2beta2, nuclear respiratory factor 2beta2.
E4TF1-47, GA binding protein beta2 subunit, NRF-2gamma2, nuclear respiratory factor 2gamma2.
GADD 153, CHOP, growth arrest and DNA-damage-inducible gene 153.
EF1, EFgammaa, Eryf-1, GATA-1, GF-1, NF-E1 (1).
GATA-1.
GATA-2, NF-E1b (chick).
GATA-3, NF-E1c (chick).

glial cells missing factor a.
glial cells missing factor a.
NR6A1, RTR, NCNF, GCNF, GCN, NCN, germ cell nuclear factor, retinoid acid receptor-related testis-associated receptor, ne
NR6A1, RTR, NCNF, GCNF, GCN, NCN, germ cell nuclear factor, retinoid acid receptor-related testis-associated receptor, ne
NR6A1, RTR, NCNF, GCNF, GCN, NCN, germ cell nuclear factor, retinoid acid receptor-related testis-associated receptor, ne
growth factor independence 1.
glucocorticoid receptor, GR, NR3C1.
glucocorticoid receptor, GR, NR3C1, GR alpha.
Thing1, Th1, eHand, Hxt, heart- and neural crest derivatives-expressed 1.
HTF4, HTF4A, TCF-12.
NSCL1, NSCL-1, NHLH1, pp20(HEN1).
HNF-3/Fkh Homolog 1, HFH1.
HNF-3/Fkh Homolog 3, HFH3.
hypoxia-inducible factor 1.
             Hlf, hepatic leukemia factor.
             H6 homeobox 3, NKX5-1, Nkx-5.1.
             APF, HNF1, HNF-1alpha, LF-B1.
             APF, HNF1, HNF-1alpha, LF-B1, HNF-1A.
             LF-B3, TCF-2, vHNF-1, LFB3, vHNF1.

             Hepatocyte Nuclear Factor 3 alpha, HNF3A.
             HNF3B, HNF3beta.
             HNF3beta, XFD-3, XFD3, Xenopus fork head domain factor 3.
             AF-1, HNF4, hepatocyte nuclear factor 4, NR2A1.
             AF-1, HNF4, NR2A1, HNF4A.
             HNF4, HNF-4, hepatocyte nuclear factor 4, hepatocyte nuclear factor 4alpha1, NR2A1.
             hepatocyte nuclear factor 4alpha2, NR2A1.
             hepatocyte nuclear factor 4alpha3, HNF-4C, NR2A1.
             hepatocyte nuclear factor 4alpha4, NR2A1.
             hepatocyte nuclear factor 4alpha7, NR2A1, HNF-4alphaP2.
             hepatocyte nuclear factor 4gamma, HNF4G, NR2A2.


             Hox-1.3, Hoxa-5, Chox-1.3 (chick).
             Hoxa-9, Hox-1.7, XhoxB1 (Xenopus).

             HOX1G.
             HP1 site factor.
             HSF, HSF1, HTF, mHSF1, heat shock transcription factor 1.
             hepatocarcinogenesis-related transcription factor.
             ICSBP, IFN consensus sequence binding protein, IRF-8, IRF8.
             LyF-1, Ikaros 1.
             LyF-1, Ikaros 3.
             insulin promoter factor 1, STF1, somatostatin transactivating factor 1, Pdx1, pancreas/duodenum homeobox 1.
             IRF10, Interferon regulatory factor 10.
             IRF-2, PRDI-BFc, PRDI-BFi.
             INTERFERON REGULATORY FACTOR 3, IRF-3, irf3, IRF3.
             IRF4, lymphocyte specific interferon regulatory factor, LSIRF, NF-EM5, interferon regulatory factor 4, MUM1.
             IRF-5, IRF5, Interferon Regulatory Factor 5.
             Interferon Regulatory Factor 6, IRF-6, IRF6.
             IRF7, IRF-7, Interferon regulatory factor 7.
             interferon regulatory factor 7.
             interferon regulatory factor 7.
             E factor, factor e, ISGF-3.
             E2-2, ITF-2, E32, SEF2-1B.
             EGR2 (human), Krox-20.
             EGR1, EGR1 (human), ETR103 (human), Krox-24, NGFI-A, TIS-8, zif268.
             Nrf1 (short form), TCF11.
             LEF 1, LEF-1L, lymphoid enhancer binding factor 1.
             Xlim-3 (Xenopus), P-Lim, Lim-3.

             LIM-only protein 2, RBTN2, Rhombotin-2, TTG-2.
             NR1H3, RLD1, LXR, oxysterol receptor LXRalpha, liver X receptor alpha, nuclear orphan receptor LXR-alpha, oxysterol recepto
pha:RXR-alpha
             NR1H2, oxysterol receptor LXR-beta, nuclear orphan receptor LXR-beta, ubiquitously expressed nuclear receptor, orphan nucl
 ta:RXR-alpha
mammary activating factor.

Myn, Myc-binding novel HLH/LZ protein.
Max, Myn (mouse), p21.
Myn, p22.
Myc-associated zinc finger protein, Pur-1, purine-binding transcription factor 1.
MAZ related factor.
MEF-2, MEF-2A.

MEF2D, MEF-2D, MEF2DAB, MEF-2D isoform AB, MEF-2D (514 AA form) (mouse), MEF-2D isoform 1a (mouse).
myeloid ecotropic viral integration site 1.
myeloid ecotropic viral integration site 1a, Meis1.
myeloid ecotropic viral integration site 1b, Meis1.
MIF.
herculin (mouse), MRF4, Myf-6 (human).
MEP-1, metal element protein-1, MTF-1, metal-regulatory transcription factor 1.
MEF1, Myf-3 (human), MyoD, MyoD1.
Myf-4 (human), MyoG, myogenin.
new ets-related factor, ELF2, ELF2B.
CCAAT-binding factor, CCAAT box-binding transcription factor, CTF, NF-1, NF-1 (-like proteins), NF-1-like, NF-I, TGGCA-bind
NF1/L, RPF-A (hamster), NF-1A1.1 (chick), NF-I/L.
NF-1B1 (chick), NF-1/Red1, NFI-B1, RPF-B.
NF-1A1, NFI-A1, RPF-A (hamster).
NF-1B1, NF-1/Red1 (hamster), NFI-B1, RPF-B.
NF-1B2, NFI-B2.
CTF-2 (human), NF-1C2, NFI-C2.
NF-1/X, NFI-X.
IgNF-A, NF-A, NF-A1, NF-A2, oct-B1A, oct-B1B.
NFE2.
nuclear factor erythroid 2 p45.
NF-EM5, PU.1 interaction partner, Pip, lymphoid-specific interferon regulatory factor, LSIRF-2, interferon regulatory factor 4, IR
NF-kappaB, NF-kappaB complex, p50/p65.
243/NFA-kappaB, EBP-1, H2TF1, KBF1, NF-kappaB (p50), p50.
KBF1, p110, p105, NF-kappaB1 (p105), NF-kappaB1 (p110).
Lyt-10, NF-kappaB2, p52, NF-kappaB2 (p52).
p49.
H2TF1, p100, p97, p98/p55, NF-kappaB2 (p100), NF-kappaB2 (p97).
NF-muE1.
NF-kappaB-like factor, NF-TNF.
alpha-CP1, CBF(2), CCAAT-binding factor, CP1, CP1 (human, rat), NF-Y, NF-YA + NF-YB, NF-YA:NF-YB:NF-YC.
CBF-B (rat), CP1B (human, rat), HAP2 (yeast), NF-YA.
CBF-A (rat), CP1a (human, rat), HAP3 (yeast), NF-YB.
CBF-C (rat), CP1C (human).
NGFI-C, pAT 133 (hu), EGR4, Egr-4.
Nkx-2.2, NKX2B.
Csx, Nkx-2.5, cardiac-specific homeobox protein.
Nkx-2.2, Nkx2-2.
Nkx-3.1, NKX3A.
Nkx-3.1, NKX3.1.
Nkx-3.1, NKX3.1.
Nkx-3.1, NKX3.1.
Nkx-3.1, NKX3.1.
Nkx-3.1, NKX3.1.
Nkx-6.1, Nkx6.1, Nkx6A.
Nkx-6.1, Nkx6.1.

alpha-PAL, alpha-palindrome-binding protein, nuclear respiratory factor 1.
NF-E2 related factor 2, NFE2-related factor 2, nuclear factor, erythroid derived 2, like 2, NFE2L2, NRF2, NRF-2.


B2 octamer binding factor, oct-B2.
oct-B3.
Olf-1, Olf1.
HuP48 (human), Pax-1, PAX1, mPax-1, mPax1.
PAX2, hPax2, hPax-2.
Pax-2, PAX2, mPax2, mPax-2.
HuP2 (human), PAX3, mPax-3, mPax3.
PAX4, mPAX4, Pax-4, mPax-4.
PAX4, Pax-4.
BSAP, Pax-5, B-cell specific activator protein, PAX5, mPax5, mPax-5.
Pax-6, Sey, PAX6, Small eye, mPax-6, mPax6.
PAX8, mPax-8, mPax8.


Pbx-1, Pbx1, pre B-cell leukemia transcription factor 1a, Prl.
CBF, PEA2, PEBP2, PEBP3, core binding factor, polyomavirus enhancer-binding protein 2, MyNF1.
Osf2, CBFA1, PEBP2alphaA.
PEBP2alpha1, PEBP2alphaA, AML3, CBF-alpha 1, RUNX2.
PEBP2alpha2, CBFA1, PEBP2alphaA.
AML1, PEBP2alphaB, CBFA2, AML1b.
AML1, PEBP2alphaB, CBFA2.
Ptx-2, Pitx2, RGS, Otlx2, RIEG, Ptx2.
Pit-1, GHF-1, Pit-1b, pituitary-specific positive transcription factor 1, growth hormone factor 1.
alpha-H1, IgNF-A, NF-A, NF-A1, NF-III, OBP100, Oct-1, octamer-binding factor, oct-B1A, oct-B1B, OTF-1, TRF.
alpha-H1, IgNF-A, NF-A, NF-A1, NF-III, OBP100, Oct-1, octamer-binding factor, oct-B1A, oct-B1B, OTF-1, TRF.
alpha-H1, IgNF-A, NF-A, NF-A1, NF-III, OBP100, Oct-1, octamer-binding factor, oct-B1A, oct-B1B, OTF-1, TRF.
IgNF-A, NF-A, NF-A2, NF-III, Oct-2, Oct-2A, OTF-2, OTF-2A, Oct-2.2.
Oct-2B, OTF-2B, Oct-2.5.
Oct-2C.
N-Oct-3, Oct-7, Brn-2, Brain-2.
Brain-5 (c2), Emb (c2), Brn-5 (c2).
peroxisome proliferator-activated receptor, peroxisome proliferator-activated receptor alpha, PPAR, PPARalpha, NR1C1.
peroxisome proliferator-activated receptor gamma, PPARgamma, NR1C3.
peroxisome proliferator-activated receptor gamma, PPARgamma, NR1C3.
peroxisome proliferator-activated receptor gamma, PPARgamma, NR1C3, peroxisome-proliferator-activated receptor gamma 2
progesterone receptor.
PTF-1.
NR1I2, pregnane X receptor, PXR.


NR1I2, pregnane X receptor, PXR.

BRLF1, factor R, R, R factor.
retinoic acid receptor alpha, NR1B1, RARa.
pha:RXR-alpha
pha:RXR-gamma
            RAR-alpha, retinoic acid receptor alpha, NR1B1.
            RAR-beta, retinoic acid receptor beta, NR1B2.
            RAR-gamma, retinoic acid receptor gamma.

            NF-kappaB (p65), Rel-A, p65.
            EF-C, RFX, RF-X, enhancer factor C.
            RAR-related orphan receptor alpha1, NR1F1.
            RAR-related orphan receptor alpha2, NR1F1.
            Ras-responsive element binding protein 1.
            RSRFC4.
            retinoid X receptor alpha, RXR-alpha, NR2B1.
            H2RIIBP, retinoid X receptor beta, RXR-beta, NR2B2.
            Prx-2.
            Ad4BP, NR5A1, steroidogenic factor 1, STF-1, fushi tarazu factor homolog 1.


            SRY-related HMG-box gene 5.
            SRY-related HMG-box protein 9, SOX9.
            SPR-2, SP-3.




            serum response factor.
            SRF-I.
            SRF-S.
            SRF-M.
            CArG-binding factor, CBF (3), p67, p67SRF, SRF, serum response factor, SRF-L.
            Se-Cys tRNA gene transcription activating factor.
            STAT91, ISGF3alpha p91, signal transducer and activator of transcription 1.
            STAT91, ISGF3alpha p91.
            GAF, STAT84, ISGF3alpha p84.
            STAT113, signal transducer and activator of transcription 2, ISGF3alpha p113.
            signal transducer and activator of transcription 3, APRF, acute-phase response factor.
            signal transducer and activator of transcription 4.
            MGF, signal transducer and activator of transcription 5 A, mammary gland factor, STF-IL-3.
            MGF, signal transducer and activator of transcription 5 A, mammary gland factor, STF-IL-3.
            signal transducer and activator of transcription 6.

            SCL, Tal-1, TCL5, pp42-TAL1, Tal-1alpha, T-cell acute lymphocytic leukemia-1 protein, stem-cell leukemia protein.

            Tax.
            TBP, TFIID, TFIIDtau, TATA-binding protein.
            TBP, TFIID, TFIIDtau, TATA-binding protein.
            T cell factor 1, TCF-1, TCF-1P, TCF-7, TCF7.

            Thyrotroph Embryonic Factor.

            ETS-related protein TEL2, TEL-related ETS factor, TEL2, TELB, Tref.
DBF3, TFIIA.
TFIIA-LN/LC, TFIIA-L.
TFIIA-S.
factor e, TFIIB, FA, CB, CI, alpha (rat).
TFIID.
TFII-I, SPIN, General Transcription Factor II-I, GTF2I, BAP-135.
5 TG3 interacting factor, TG-interacting factor.
T/EBP, TTF-1, Nkx2.1, Nkx-2.1.
gamma-factor, USF, upstream stimulatory factor.
eUSF (duck), MLTF, pf51, UEF, USF, USF1, upstream stimulatory factor.
CIIIB1.
USF II, USF44, FIP, Fos-interacting protein, upstream stimulatory factor 2.
DBP, VBP.
VDR, vitamin D receptor, NR1I1, 1,25-dihydroxyvitamin D3 receptor.
c-ErbA, c-ErbA-alpha, v-ErbA, c-ErbAalpha.
LF-B3, vHNF-1, LFB3, vHNF-1A, vHNF1.
HNF-1beta, vHNF-1, vHNF-1A.


v-Jun.

alpha-TIF, ICP25, Vmw65, VP16.
v-Myb.
hXBP-1, TREB-5, XBP-1, X-box binding protein 1.

AP1, yAP1, PAR1, PDR4, SNQ3, YML007W.
62K protein, delta factor, F-ACT1, MAPF1, NF-E1 (2), Yin and Yang 1, YY-1, NMP-1, nuclear matrix protein 1.
zinc finger protein with interaction domain.
BZLF1, EB1, ZEBRA, Zta, Z protein.
organism
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
clawed frog, Xenopus laevis
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
rat, Rattus norvegicus
rat, Rattus norvegicus
rat, Rattus norvegicus
rat, Rattus norvegicus
human, Homo sapiens
mouse, Mus musculus
golden (Syrian) hamster, Mesocricetus auratus
mouse, Mus musculus
chick, Gallus gallus
chick, Gallus gallus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
dog, Canis canis
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
rat, Rattus norvegicus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
BPV-1, bovine papilloma virus type 1
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
clawed frog, Xenopus laevis
clawed frog, Xenopus laevis
clawed frog, Xenopus laevis
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
rat, Rattus norvegicus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
clawed frog, Xenopus laevis
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
rat, Rattus norvegicus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
clawed frog, Xenopus laevis
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
rat, Rattus norvegicus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
rat, Rattus norvegicus
rat, Rattus norvegicus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
rat, Rattus norvegicus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
rat, Rattus norvegicus
clawed frog, Xenopus laevis
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
rat, Rattus norvegicus
mouse, Mus musculus
mouse, Mus musculus
zebra fish, Brachydanio rerio
human, Homo sapiens
rat, Rattus norvegicus
mouse, Mus musculus
rat, Rattus norvegicus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
chick, Gallus gallus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
chick, Gallus gallus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
rat, Rattus norvegicus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
rat, Rattus norvegicus
hamster
chick, Gallus gallus
chick, Gallus gallus
chick, Gallus gallus
chick, Gallus gallus
hamster
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
rat, Rattus norvegicus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
rat, Rattus norvegicus
human, Homo sapiens
human, Homo sapiens
rat, Rattus norvegicus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
rat, Rattus norvegicus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
zebra fish, Brachydanio rerio
zebra fish, Brachydanio rerio
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
clawed frog, Xenopus laevis
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
rat, Rattus norvegicus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
EBV, Epstein-Barr virus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
clawed frog, Xenopus laevis
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
HTLV-I, human T-cell lymphotropic virus type I
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
mouse, Mus musculus
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
mouse, Mus musculus
human, Homo sapiens
mouse, Mus musculus
mouse, Mus musculus
chick, Gallus gallus
mouse, Mus musculus
rat, Rattus norvegicus
rat, Rattus norvegicus
chick, Gallus gallus
mouse, Mus musculus
AEV, avian erythroblastosis virus
domestic pig, Sus scrofa
human, Homo sapiens
human, Homo sapiens
human, Homo sapiens
ASV, avian sarcoma virus
AS42, avian musculoaponeurotic fibrosarcoma virus
HSV-1, herpes simplex virus type 1
AMV, avian myeloblastosis virus
human, Homo sapiens
clawed frog, Xenopus laevis
yeast, Saccharomyces cerevisiae
human, Homo sapiens
human, Homo sapiens
EBV, Epstein-Barr virus
TF ID                     Organism Organism class
         TF Name TF Synonym                  URL                           Functional Features
                                                               Structual features      Cell specifity
                                                               belongs
                                                               to the
                                                               Granyhea
                                                               d-like
                                                               family of
                                                               TFs,
                                                               together
                                                               with
                                                               Drosophil
                                                               a Elf-
                                                               1/NTF-1 activator
                                                               factors,    [3]
                                                               and likely appears
                                                               presents to be
                                                               novel       functionall
                                                               type of     y limiting
                                                               DNA         in nuclear
                                                               binding     B cell
                                                               recognize extracts
                  alpha-                                       s DNA       activates
                  CP2a,                                        elements transcripti
                  alpha-                                       consisting on of
                  CP2a,                                         of two     alpha-
                  alpha-                                       directly    globin
                  CP2b,                                        repeated gene [8]
                  CP-2,                         http://local   half-sites [9] [6] [7],
                  LSF, SEF-                     host/cgi-      [5]         of the
                  1, alpha-                     bin/biobas     glutamine- major
                  CP2, LBP-                     e/transfac/    rich        acute
                  1c, SAA mouse,                7.4/bin/get    region,     phase
                  enhancer Mus       vertebrate TFProf.cgi     phosphory gene
T00152   CP2      factor 1. musculus s          ?T00152        lation      SAA3 [3]. NULL
                                                                           stimulates
                                                                            basal
                                                                           transcripti
                                                                           on, but is
                                                              three        not
                                                              subunits:    indispens
                                                              alpha,       able for
                                                              beta,        pol II
                                                              gamma        transcrptio
                                                              [9] alpha    n [14] [9]
                                                              and beta     binds to
                                                              are          and
                                                              processed    stabilizes
                                                               from a      TFIID/TB
                                                              common       P-TATA
                                                              alpha/beta   box-
                                                                           complexe
                                                              precursor    s [14] it
                                                              <T02216>     decreases
                                                               holo-        the
                                                              TFIIA is     influence
                                                              active       of
                                                              either as    sequence
                                                              dimeric      s flanking
                                                              alpha/beta   the TATA-
                                                               +           box,
                                               http://local   gamma        casus a
                                               host/cgi-      or as        conformati
                                               bin/biobas     trimeric     onal
                                               e/transfac/    alpha+bet    change of
                          human,               7.4/bin/get    a+gamma      TBP and
                 DBF3,    Homo      vertebrate TFProf.cgi      complex     neutralize
T00817   TFIIA   TFIIA.   sapiens   s          ?T00817        [3] [4]      s the       (HeLa)
                                                                  the N-        holo-
                                                                  terminal      TFIIA
                                                                  part          binds to
                                                                  represent     and
                                                                  s the         stabilizes
                                                                  alpha, the    TFIID/TB
                                                                  C-            P-TATA
                                                                  terminal      box-
                                                                  part the      complexe
                                                                  beta          s [11] it is
                                                                  subunit,      an
                                                                  the           antirepres
                                                                  processin     sor by
                                                                  g point       displacing
                                                                  being         inhibiting
                                                                  located       TFIID-
                                                                  around        componen
                                                                  position      ts [8] [6]
                                                                  275 [6] [7]   [5] and an
                                                                  [3]           activator
                                                                  pI(calc.) =   through
                                                                  4.25 [6]      interaction
                                                                  processin      with
                                                                  g is no       some
                                                                  prerequisit   other
                                                                  e for         TFIID
                                                   http://local   functional    componen
                                                   host/cgi-      assembly      ts [5] the
         TFIIA-                                    bin/biobas     with the      alpha-
         alpha/beta                                e/transfac/    gamma         subunit
                   TFIIA-     human,               7.4/bin/get    subunit       specificall
         precursor LN/LC,     Homo      vertebrate TFProf.cgi     [4] [5] the   y
T02216   (ma       TFIIA-L.   sapiens   s          ?T02216        alpha         mediates (HeLa)
                                                          N-
                                                          terminally
                                                          extended
                                                          form is an
                                                          alternative

                                                          translation
                                                           initiation
                                                          product
                                                          <T02216>
                                                           the N-
                                                          terminal
                                                          part
                                                          represent
                                                          s the
                                                          alpha, the
                                                          C-
                                                          terminal
                                                          part the
                                                          beta
                                                          subunit,
                                                          the
                                                          processin
                                           http://local   g point
                                           host/cgi-      being
         TFIIA-                            bin/biobas     located
         alpha/beta                        e/transfac/    around
                      human,               7.4/bin/get    position
         precursor    Homo      vertebrate TFProf.cgi     236 [2] [3]
T02217   (mi          sapiens   s          ?T02217        [1]           (HeLa)
                                                                 assemble
                                                                 s active
                                                                 holo-
                                                                 TFIIA
                                                                 either
                                                                 with
                                                                 alpha/beta
                                                                 -
                                                                 precursor
                                                                 or with
                                                                 alpha and
                                                                 beta
                                                                 subunits
                                                  http://local   [3] [4] by
                                                  host/cgi-      interacting
                                                  bin/biobas      with the
                                                  e/transfac/    alpha, but
                             human,               7.4/bin/get    not with
         TFIIA-              Homo      vertebrate TFProf.cgi     the beta
T02224   gamma    TFIIA-S.   sapiens   s          ?T02224        moiety [4]    (HeLa)
                                                                 pI(calc.) =   binding to
                                                                 8.32 [23]     (TATA-
                                                                 resemblin     DNA)+TFI
                                                                 g the         ID(+TFIIA)
                                                                 overall
                                                                 structure     enhances
                                                                 of TBP in     affinity of
                                                                 exhibiting    TBP to
                                                                 also two      DNA [13]
                                                                 direct        anchors
                                                                 repeats,      pol II to
                                                                 basic         the initial
                                                                 regions,      transcripti
                                                                 and           on
                                                                 sigma         complex
                                                                 homology      [26] may
                                                                 regions       fix the
                                                                 [24] [25]     transcripti
                                                                 forming a     on start
                                                                 protease-     site [4]
                                                                 resistant     exerts
                                                                 core [21]     similar
                                                                 [17] with     functionali
                                                                 a             ty in
                                                                 structure     conjunctio
                                                                 similar to    n with
                                                  http://local   that of       YY1
                                                  host/cgi-      cyclin A      instead of
                 factor e,                        bin/biobas     [4] [7] the   TBP [14]
                 TFIIB,                           e/transfac/    direct        taret of
                 FA, CB,     human,               7.4/bin/get    repeats       certain
                 CI, alpha   Homo      vertebrate TFProf.cgi     (112-316)     autoantibo
T00818   TFIIB   (rat).      sapiens   s          ?T00818        are alpha-    dies [11] NULL


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                 factor e, rat,                  e/transfac/
                 TFIIB,     Rattus               7.4/bin/get
                 FA, CB,    norvegicu vertebrate TFProf.cgi
T02159   TFIIB   CI, alpha. s         s          ?T02159                                    NULL
                                                               basic         part of
                                                               region        MEF-1
                                                               contacts      complex
                                                               DNA,          induces
                                                               HLH           hyperphos
                                                               domain is     phorylatio
                                                               the           n of
                                                               dimerizati    MyoD
                                                               on            upon
                                                               interface     associatio
                                                               [18] binds    n induces
                                                               DNA           transcripti
                                                               avidly as     on of IgH,
                                                               homodime      but also
                                                               r             of IgH-
                                                               (contrastin   stimulatin
                                                               g to E12),    g Oct-2
                                                               or as         gene, and
                                                               heterodim     recombina
                                                               er [8]        tion-
                                                               from          activating
                                                               crystal       genes
                                                               structure:    RAG-1
                                                               dimerizati    and -2
                                                               on            thus
                                                               domain        stimulatin
                                                http://local   forms a       g IgH
               BCF-1,                           host/cgi-      parallel      rearrange
               E2A.E47,                         bin/biobas     four-helix-   ment as
               E2A-E47,                         e/transfac/    bundle [3]    well [12]
               E47,        human,               7.4/bin/get    helix 1 is    in acute
               IEBP1       Homo      vertebrate TFProf.cgi     one turn      lymphobla
T00207   E47   (rat), E2A. sapiens   s          ?T00207        longer        stic        ubiquitous
                                                                 bHLH         activator
                                                                 region is    (as
                                                                 87%          heterodim
                                                                 identical    er with
                                                                 to that of   E2A-
                                                                 Hand2        proteins),
                                                                 <T04370>     may also
                                                                  [2] no      exert
                                                                 homodime     repressor
                                                                 rization,    function
                                                                 DNA-         [7]
                                                                 binding      induces
                                                                 depends      trophoblas
                                                                 on           t
                                                                 heterodim    formation
                                                                 erization    in
                                                                 [7] the      preimplant
                                                                 Hand1-       ation
                                                                 bound        embryos
                                                                 half-sites   while Id-1     (E10.5:)
                                                                 are highly   <T00403>       portions
                                                                 degenerat      inhibits     of the
                 Thing1,                                         e [7]        trophoblas     heart,
                 Th1,                                            Hand1        t              autonomic
                 eHand,                                          and          differentiat    ganglia,
                 Hxt, heart-                                     Hand2        ion [3]        gut,
                  and                            http://local    <T04370>     role in left   pharyngea
                 neural                          host/cgi-        show a      chamber-       l arches;
                 crest                           bin/biobas      compleme     specific       (adult:)
                 derivative                      e/transfac/     ntary        cell fate      intestine,
                 s-          mouse,              7.4/bin/get     assymetri    decisions      lung,
                 expressed Mus        vertebrate TFProf.cgi      cal          and            placenta
T01569   Hand1    1.         musculus s          ?T01569         expressio    possibly       [7]


                                                  http://local
                 MLTF,                            host/cgi-
                 UEF,                             bin/biobas
                 USF,                             e/transfac/
                 upstream                         7.4/bin/get
                 stimulator            vertebrate TFProf.cgi
T00870   USF     y factor.  hamster    s          ?T00870                                    NULL


                                                  http://local
                 gamma-                           host/cgi-
                 factor,                          bin/biobas
                 USF,                             e/transfac/
                 upstream chick,                  7.4/bin/get
                 stimulator Gallus     vertebrate TFProf.cgi
T00872   USF     y factor.  gallus     s          ?T00872                                    NULL
                                                http://local
                 eUSF,                          host/cgi-         may
                 USF,                           bin/biobas        anchor
                 USF1,                          e/transfac/       TFIID to
                 upstream duck,                 7.4/bin/get       a TATA-
                 stimulator Cairina  vertebrate TFProf.cgi        less
T00876   USF     y factor.  moschata s          ?T00876           promoter   NULL


                                                   http://local
                 MLTF,                             host/cgi-
                 USF,                              bin/biobas
                 USF1,        rat,                 e/transfac/
                 upstream     Rattus               7.4/bin/get
                 stimulator   norvegicu vertebrate TFProf.cgi
T00875   USF-1   y factor.    s         s          ?T00875                   NULL
                                                                  transcripti
                                                                  onal
                                                                  activator
                                                                  (together
                                                                  with Mitf
                 eUSF                                             <T01554>
                 (duck),                                          ) of the T-
                 MLTF,                                            box
                 pf51,                          http://local      transcripti
                 UEF,                           host/cgi-         on factor
                 USF,                           bin/biobas        Tbx2
                 USF1,                          e/transfac/       <T04358>
                 upstream mouse,                7.4/bin/get        in
                 stimulator Mus      vertebrate TFProf.cgi        melonocyt
T00877   USF-1   y factor.  musculus s          ?T00877           es [1]      NULL
                                                               immunolo     transcripti
                                                               gically      onal
                                                               unrelated    activator
                                                               with         [10] [11]
                                                               USF44        [13]
                                                               [17] [24]    cooperativ
                                                               [13]         e
                                                               bends        interaction
                                                               DNA           with TFII-
                                                               towards      I [14] and
                                                               the minor    TFIID
                                                               groove by    [25] may
                                                               74-82        have to
                                                               deg [7]      direct
                                                               DNA-         stable
                                                               binding is   preinitiatio
                                                               sensitive    n
                                                               to CpG       complex
                                                               methylatio   formation
                                                               n [23] the   during
                eUSF                                           basic        chromoso
                (duck),                                        region       me
                MLTF,                                          contacts     assembly
                MRF                                            DNA          [16] is
                (yeast),                                       within the   stimulated
                pf51,                                          major         by
                UEF,                            http://local   groove,      C/EBPalp
                USF,                            host/cgi-      thereby      ha to
                USF43,                          bin/biobas     adopting     transactiv
                USF1,                           e/transfac/    alpha-       ate the
                upstream human,                 7.4/bin/get    helical      human
                stimulator Homo      vertebrate TFProf.cgi     conformati   C/EBPalp
T00874   USF1   y factor.  sapiens   s          ?T00874        on [3]       ha gene ubiquitous
                                                                           represses
                                                                           Sp1-
                                                                           mediated
                                                                           transactiv
                                                                           ation
                                                                           through
                                                                           uteroglobi
                                                                           n
                                                             given         promoter
                                                             sequence      element II
                                                             is N-         [1]
                                                             terminally    suppressi
                                                             truncated     on of Tat-
                                                             [3] 6         mediated
                                                             potential     transactiv
                                                             N-            ation [2]
                                                             glycosylati   represses
                                                             on sites      basal
                                                             (N-X-S/T)     expressio
                                                             [3]           n of HIV
                                              http://local   homology      promoter
                                              host/cgi-      to factors    [2] not
                                              bin/biobas     Sp1           able to
                                              e/transfac/    <T00759>      cooperate
                        human,                7.4/bin/get     and SP4       with NF-
               SPR-2,   Homo       vertebrate TFProf.cgi     <T02339>      kappaB     ubiquitous
T02338   Sp3   SP-3.    sapiens    s          ?T02338         [3]          [2]        [2]


                                              http://local
                                              host/cgi-
                                              bin/biobas
                                              e/transfac/
                        chick,                7.4/bin/get
               SPR-2,   Gallus     vertebrate TFProf.cgi
T02419   Sp3   SP-3.    gallus     s          ?T02419                                   NULL


                                             http://local
                                             host/cgi-                     involved
                                             bin/biobas                    in
                        rat,                 e/transfac/                   mediating    (adult:)
                        Rattus               7.4/bin/get                   ethanol-     lung
                        norvegicu vertebrate TFProf.cgi                    induced      epithelial
T02453   Sp3            s         s          ?T02453                       stress [1]   cell line [2]
                                                                 binds to
                                                                 initiator
                                                                 regions
                                                                 (Inr),
                                                                 cooperate
                                                                 s with
                                                                 USF
                                                                 interaction
                                                                  with
                                                                 Phox1
                                                                 and SRF
                                                                 in vitro
                                                                 and in
                                                                 vivo [1]
                                                                 promotes
                                                                 the
                                                                 formation
                  TFII-I,                                        of Phox1-
                  SPIN,                           http://local   dependent
                  General                         host/cgi-       signal
                  Transcripti                     bin/biobas     responsiv
                  on Factor                       e/transfac/    e
                  II-I,       human,              7.4/bin/get    complexe
                  GTF2I,      Homo     vertebrate TFProf.cgi     s on the
T00824   TFII-I   BAP-135. sapiens     s          ?T00824        SRE [1]     NULL
                                                                            involved
                                                              in            in
                                                              skeletal      myogenes
                                                              and heart     is [6]
                                                              muscle        cooperate
                                                              cells,        s with
                                                              MEF-2         myogenic
                                                              recognize     bHLH
                                                              s the         factors [6]
                                                              same          induces
                                                              sequence      MyoD [6]
                                                              motif [3]     induced
                                                              MEF-2 in      by
                                                              brain         myogenin
                                                              binds to      [8]
                                                              an            cooperate
                                                              extended      s with
                                                              sequence,     MyoD
                                                               possible     through
                                                              due to        direct
                                                              interaction   interaction
                                                               with         s and by
                                                              additional    binding to
                                                              factors [3]   either
                                                              gene          MEF-2
                                                              expressio     sites or to
                                               http://local   n in          E-box
                                               host/cgi-      developin     elements
                                               bin/biobas     g brain       [4]           myogenic
                                               e/transfac/    see for       expressio     cells,
                           mouse,              7.4/bin/get    detailed      n in          brain [7];
                 MEF-2,    Mus      vertebrate TFProf.cgi     informatio    cerebellu     developin
T00505   MEF-2   MEF-2A.   musculus s          ?T00505        n [5]         m: begins     g brain [5]
                                                                                           (embryo
                                                                                           8.5 days:)
                                                                                           tail bud,
                                                                                           caudal
                                                                            activator      neural
                                                                            of             plate/tube
                                                                            intestine-     and
                                                                            specific       notochord
                                                                            promoters      , (embryo
                                                                             [7] [2]       12.5 d.)
                                                                            may be         gut
                                                                            redox-         endoderm
                                                                            regulated      , caudal
                                                                            [7]            tip of
                                                                            regulatate     neural
                                                                            s both         tube,
                                                                            proliferatio   (embryo
                                                                            n and          >15 d.)
                                                                            differentiat   intestinal
                                                                            ion in         epithelial
                                                                            intestinal     cells
                                                                            epithelial     (duodenu
                                                                            cells [5]      m,
                                                                            CBP is a       jejunum,
                                                 http://local               coactivato     ileum,
                                                 host/cgi-                  r              cecum,
                 CDX2,                           bin/biobas                 interacting    colon),
                 caudal                          e/transfac/                 with the      cell lines
                 homolog mouse,                  7.4/bin/get    dimeric     homeo          (STC-1,
                 homeobox Mus         vertebrate TFProf.cgi     DNA-        domain of      GLUTag)
T02002   Cdx-2    protein 2. musculus s          ?T02002        binding [7] Cdx-2 [1]      [7] [2]
                                                                          activator
                                                                          of the
                                                                          insulin
                                                                          and
                                                                          glucagon
                                                                          gene [3]
                                                                          [2]
                                                                          probably
                                                                          involved
                                                                          in the
                                                                          post-
                                                                          weaning
                                                                          decline of
                                                                          lactase-
                                                                          phlorizin
                                                                          hydrolase
                                                                          (LPH)
                                                                          causing
                                                                          lactose
                                                                          intoleranc
                                                                          e [1] Cdx-
                                                                          2/3
                                                              similar     mediates
                                                              DNA-        activation
                                                              binding     of the       intestine,
                                                              specificity proglucag    pancreas
                                                 http://local as Lmx-1 on              islets, low
                            golden               host/cgi- [3] Cdx-3 promoter          levels in
                            (Syrian)             bin/biobas is the        in both      testis [3];
                            hamster,             e/transfac/ hamster islet and         cell lines
                            Mesocrice            7.4/bin/get homologu enteroend        (INR1-G9
                 Cdx-2,     tus       vertebrate TFProf.cgi e of Cdx- ocrine           and HIT
T02003   Cdx-3   shCdx-2.   auratus   s          ?T02003 2 [2] [1]        cells [2]    cells) [2]
                                                               the Clox
                                                               homolog
                                                               is a splice
                                                               variant [5]
                                                               the 3 cut
                                                               repeats
                                                               also
                                                               contribute
                                                               to DNA-
                                                               binding,
                                                               each
                                                               individual
                                                               repeat
                                                               and each
                                                               combinati
                                                               on
                                                               exhibiting    repressor
                                                               slightly      [13] [12]
                 CDP,                                          different     [9] [8] [6]
                 CCAAT                                         DNA-          [3] may
                 displacem                                     binding       regulate
                 ent                                           specificity   S/MAR-
                 protein,                                      [4] [2] [5]   binding
                 cut                                           CR1           factor
                 homeodo                                       exhibits      SATB1
                 main                                          the most      and may
                 protein,                       http://local   restricted    be
                 Cux, cut-                      host/cgi-      resognitio    regulated
                 like                           bin/biobas     n pattern     by it via
                 homeodo                        e/transfac/    [4] KD        protein-
                 main      human,               7.4/bin/get    (CR3-         protein
                 protein,  Homo      vertebrate TFProf.cgi     homeo         interaction
T00100   CUTL1   Clox.     sapiens   s          ?T00100        domain)        [1]        NULL
                                                                AREB6 is
                                                                the
                                                                extended
                                                                form of
                                                                Nil-2-a [4]
                                                                Nil-2-a
                                                                was
                                                                originally
                                                                reported      repressor
                                                                to be a       of
                                                                protein of    interleukin
                                                                735 AA        -2
                                                                with an       expressio
                                                                expected      n [6]
                                                                molecular     repressor
                 Nil-2-a,                                       weight of     of the
                 TCF8                                           80.5 kDa      immunogl
                 (gene                                          containing    obulin
                 name),                                          3 zinc       heavy-
                 AREB6,                                         finger        chain
                 Atp1a1                                         motifs        enhancer
                 Regulator                                      zinc          [3]
                 y Element                                      finger 4 is   transcripti
                 Binding                                        of C2HC-      onal
                 protein 6,                                     type,         repression
                 ZEB, zinc                                      while the      might be
                 finger E-                       http://local   others        mediated
                 box-                            host/cgi-      are of        by the
                 binding                         bin/biobas     C2H2-         negative
                 protein,                        e/transfac/    type [4]      cofactor      T cells;
                 negative human,                 7.4/bin/get    S/T-rich      NC2           heart [4];
                 regulator Homo       vertebrate TFProf.cgi     region        <T00197>      skeletal
T00625   AREB6   of IL2.    sapiens   s          ?T00625        between        [1]          muscle [4]
                                                              spectrosc    transcripti
                                                              opic data:   onal
                                                              CD [15]      activator
                                                              [14], EPR    [36] of
                                                              [15]         muscle-
                                                              crystal      specific
                                                              structure    genes
                                                              [5]          [43]
                                                              heterodim    myogenic
                                                              ers with     master
                                                              E12/E47      gene
                                                              bind         product
                                                              more         causing
                                                              avidly to    myogenic
                                                              DNA than     differentiat
                                                              homodime     ion [48]
                                                              rs [37]      [47] [41]
                                                              [25] [26]    inhibitor
                                                              the          of cell
                                                              heterodim    proliferatio
                                                              er is        n
                                                              identical    depending
                                                              to the        on the
                                                              DNA-         HLH
                                                              binding      domain
                                                              activity     [34] [35]
                                               http://local   MEF-1        can partly     proliferatin
                                               host/cgi-      [26] A114    substitute     g
                MEF1,                          bin/biobas     is           for Myf-5      myoblasts
                Myf-3                          e/transfac/    essential    and vice        and
                (human),   mouse,              7.4/bin/get    for DNA-     versa [23]     differentiat
                MyoD,      Mus      vertebrate TFProf.cgi     binding,     induced        ed
T00526   MyoD   MyoD1.     musculus s          ?T00526        T115 for     immediate      myotubes
                                                               38%           transcripti
                                                               amino         onal
                                                               acid          repressor
                                                               identity to   [3] may
                                                               Bach1         play an
                                                               <T04793>      important
                                                                [3]          role in
                                                               contains      coordinati
                                                               a BTB         ng
                                                               (broad        transcripti
                                                               complex-      onal
                                                               tramtrack-    activation
                                                               bric-a-       and/or
                                                               brac)         repression
                                                               domain         by MafK
                                                               which is a    <T01435>
                                                               protein        [3] acts
                                                               interaction   synergistic
                                                                motif [3]    ally with
                                                               binds         MafK as
                                                               both as       repressor
                                                               dimer         of the IgH    (cell
                                                               with MafK     3             lines:)
                                                               <T01435>      enhancer      M1,
                                                                and as       [2]           NIH3T3,
                                                               monomer       probably      C1300,
                                               http://local    to DNA        plays a       B220+,
                                               host/cgi-       [3] Bach2     role          B31-1, 63-
                                               bin/biobas      consensu      during B-     12, 18-
                 BTB and                       e/transfac/     s binding     cell          81,
                 CNC       mouse,              7.4/bin/get     site is       maturatio     NFS5.2,
                 homolog   Mus      vertebrate TFProf.cgi      nearly        n [2]         38B9 [3]
T04792   Bach2   2.        musculus s          ?T04792         identical     synergistic   [2] [1]


                                                http://local
                                                host/cgi-
                                                bin/biobas
                 BTB and                        e/transfac/
                 CNC       human,               7.4/bin/get
                 homolog   Homo      vertebrate TFProf.cgi
T04795   Bach2   2.        sapiens   s          ?T04795                                    NULL
                                                      size of
                                                      the gag-
                                                      maf
                                                      fusion
                                                      protein:
                                                      864 AA,
                                                      95 kDa
                                                      (gene),
                                                      100 kDa
                                                      (SDS),
                                                      with
                                                      some
                                                      variation
                                                      among
                                                      different
                                                      clones [6]
                                                      binds to
                                                      TRE-type
                                                      and CRE-
                                                      type
                                                      elements
                                                      (MAREs,
                                                      Maf
                                                      recognitio
                                                      n
                                                      elements)
                 AS42,                 http://local   with           transcripti
                 avian                 host/cgi-      equal          onal
                 musculoa              bin/biobas     affinity [1]   activator
                 poneurotic            e/transfac/    DNA-           [3] with
                                       7.4/bin/get    binding        transformi
                 fibrosarco vertebrate TFProf.cgi     specificity    ng activity
T01430   v-Maf   ma virus s            ?T01430        is similar     [5]         NULL
                                                             dimeric       activator
                                                             DNA-          and
                                                             binding       repressor
                                                             [35] co-      binding to
                                                             crystals      serum
                                                             of DNA-       response
                                                             binding       elements
                                                             domain        (SRE)
                                                             (132-223)     and
                                                             and DNA       cooperatin
                                                             (SRE):        g with
                                                             two           p62TCF,
                                                             antiparalle   Elk-1 [35]
                                                             l             [8]
                                                             amphipath     antagonist
                                                             ic alpha-     ic to YY1    (HeLa);
                                                             helices       by           chicken
                                                             (alpha-I),    binding      embryo
                                                             arranged      competitio   protein
                                                             as coiled     n [25]       (Immunop
                                                             coil,         YY1          eroxidase
                                                             approxima     binding to   staining):
               CArG-                                         tely          the          HH stage-
               binding                                       parallel      serum        12:
               factor,                                       on the        response     abundant
               CBF (3)                                       minor         element      in
               (mouse),                       http://local   groove of     (SRE) is     myocardiu
               p67,                           host/cgi-      the A/T-      essential    m and
               p67SRF,                        bin/biobas     rich          to           myotomal
               SRF,                           e/transfac/    center        enhance      portion of
               serum    human,                7.4/bin/get    [13]          SRF          anterior
               response Homo       vertebrate TFProf.cgi     helices       binding      somites
T00764   SRF   factor.  sapiens    s          ?T00764        make          [15]         [10]


                                                                       in vitro
                                                                       and in
                                                                       vivo
                                             http://local              phosphory
                                             host/cgi-                 lation by
                                             bin/biobas                casein
                        rat,                 e/transfac/               kinase II,
                        Rattus               7.4/bin/get               leading to
                        norvegicu vertebrate TFProf.cgi      phosphory induction
T00766   SRF   SRF.     s         s          ?T00766         lation    of c-fos   NULL
                                                               different
                                                               splice
                                                               variants
                                               http://local    <T00765>
                                               host/cgi-       ,
                                               bin/biobas      <T03995>
                                               e/transfac/     ,
                  serum    mouse,              7.4/bin/get     <T03996>
                  response Mus      vertebrate TFProf.cgi      ,
T05114   SRF      factor.  musculus s          ?T05114         <T03997>      NULL



                                                               full length
                                                               cDNA
                                                               clone is
                                                               <T00765>
                                                                exons 3,
                                                               4 and 5
                                                               are
                                                               missing
                                                               [1] in
                                                               alternative
                                                                splice
                                                               variant
                                                               <T03995>
                                                                exon 5 is
                                                http://local   missing,
                                                host/cgi-      in
                                                bin/biobas     <T03996>
                                                e/transfac/     exons 4
                            mouse,              7.4/bin/get    and 5 are     embryo:
         SRF (263           Mus      vertebrate TFProf.cgi     missing       E10, E13
T03997   AA)      SRF-I.    musculus s          ?T03997        [1].          [1]
                                                              full length
                                                              cDNA
                                                              clone is
                                                              <T00765>
                                                               exons 4
                                                              and 5 are
                                                              missing
                                                              [1] in
                                                              alternative
                                                               splice
                                                              variant
                                                              <T03995>
                                                               exon 5 is
                                                              missing,
                                               http://local   in
                                               host/cgi-      <T03997>
                                               bin/biobas      exons 3,
                                               e/transfac/    4 and 5
                           mouse,              7.4/bin/get    are
         SRF (400          Mus      vertebrate TFProf.cgi     missing       adult:
T03996   AA)      SRF-S.   musculus s          ?T03996        [1].          aorta [1]
                                                              full length
                                                              cDNA
                                                              clone is                    Embryo:E
                                                              <T00765>      inhibition    9,E10,E13
                                                               exon 5 is    of SRE-       ,E14
                                                              missing       dependent     [1];adult:
                                                              [1] in         promoter     testis,liver,
                                                              alternative   activity of   kidney,lun
                                                               splice       cardiac       g,uterus,a
                                                              variant       alpha-        orta,
                                                              <T03996>      actin         heart,skel
                                                               exons 4      promoter,     etal
                                                              and 5 are     skeletal      muscle
                                                              missing,      alpha-        [1]; brain,
                                                              in            actin         heart [2];
                                                              <T03997>      promoter,     C2C12
                                                               exons 3,     SM22          un- and
                                                              4 and 5       alpha         differentiat
                                                              are           promoter      ed
                                                              missing       and           myoblasts
                                                              [1]           smooth        ,
                                                              binding       alpha         myotubes
                                                              DNA as        actin         [1]; rat
                                                              homodime      promoter      VSMC
                                               http://local   r [2]         [2]           [1];
                                               host/cgi-      heterodim     repression    protein
                                               bin/biobas     erization      of serum-    level: P19
                                               e/transfac/    with C-       induced       cells,
                           mouse,              7.4/bin/get    terminal      activity of   C2C12
         SRF (440          Mus      vertebrate TFProf.cgi     truncated     c-fos-        myoblasts
T03995   AA)      SRF-M.   musculus s          ?T03995        SRF [2]       SRE [2]        [1]
                                                              binds to
                                                              serum
                                                              response
                                                              element
                                                              (SRE)
                                                              rapid and     Embryo:
                                                              transient     E9,10,13,
                                                              induction     14
                                                              of SRF        [1];adult:
                                                              mRNA          testis,liver,
                                                              synthesis     kidney,lun
                                                              after         g,uterus,a
                                                              serum         orta [1];
                                                              stimulatio    heart,sk
                                                              n (60-480     muscle
                                                              min,          [1] [4];
                                                              somewhat      kidney,spl
                                                               delayed      een,stoma
                                                              compared      ch [2];
                                                               with c-      C2C12
                                                              fos           un-,
                                                              mRNA:         differentiat
                  CArG-                                       possible      ed
                  binding                                     hint on       myoblasts
                  factor,                                     SRF role      ,myotubes
                  CBF (3),                                    in shutoff     [1];rat
                  p67,                         http://local   of c-fos      VSMC
                  p67SRF,                      host/cgi-      transcripti   [1];protein:
                  SRF,                         bin/biobas     on) [6]
                  serum                        e/transfac/    progressiv    P19,C2C1
                  response mouse,              7.4/bin/get    e             2
         SRF (504 factor,  Mus      vertebrate TFProf.cgi     phosphory     myoblasts
T00765   AA)      SRF-L.   musculus s          ?T00765        lation        [1]
                                                                          activator
                                                                          [7]
                                                                          involved
                                                                          in control  (embryo
                                                                          of          8.5 days:)
                                                                          embryoge    ventrome
                                                                          nesis [6]   dial part
                                                                          oncogenic   of
                                                                           potential, somites,
                                                                          depending   (embryo
                                                                           on an      9.5-10-5
                                                                          intact      days:)
                                                                          paired      sclerotom
                                                                          domain      e cells,
                                                                          [6]         (embryo
                                                                          mutations   12.5
                                                                          cause       days:)
                                                                          Undulated   invertebral
                                                                                       discs
                                                                          phenotype anlagen
                                                                                      [5];
                                                                          (alteration (embryo
                                                                          s in the    14.5
                                                                          vertebral days:)
                                                                          column,     perichord
                                                                          sternum, al zone
                                                http://local              scapula, [9] [5];
                 HuP48                          host/cgi-                 facial      (newborn:
                 (human),                       bin/biobas     no         skeleton ) ventral
                 Pax-1,                         e/transfac/    homeo      an          part of
                 PAX1,      mouse,              7.4/bin/get    domain     thymus), annulus
                 mPax-1,    Mus      vertebrate TFProf.cgi     pI(calc) = e. g.       fibrosus
T00677   Pax-1   mPax1.     musculus s          ?T00677        10.1.      G18S        [5]
                                                                             active
                                                                             during
                                                               comprises     mesencha
                                                                a            my-to
                                                               remnant       epithelium
                                                               of a           transition
                                                               homeo         in early
                                                               domain        kidney
                                                               similar       developm
                                                               sequence      ent [6]
                                                               specificity   overexpre
                                                               as Pax-6      ssed in
                                                               [3] as in     Wilms
                                                               murine        tumor [6]
                                                http://local   cells,        tumor
                                                host/cgi-      there may     initiation
                                                bin/biobas     be two        by
                                                e/transfac/    human         inhibiting
                 PAX2,     human,               7.4/bin/get    splice        the p53
                 hPax2,    Homo      vertebrate TFProf.cgi     variants      transcripti
T01823   Pax-2   hPax-2.   sapiens   s          ?T01823        as well [6]   on [2]      NULL
                                                                        active
                                                                        during
                                                                        mesenchy
                                                                        me-to-
                                                                        epithelium
                                                                         transition
                                                                        in early
                                                                        kidney
                                                                        developm
                                                                        ent [4]
                                                                        overexpre
                                                                        sed in
                                                                        Wilms
                                                                        tumor [4]
                                                                        oncogenic
                                                                         potential
                                                                        [3] Pax-2,
                                                                        Pax-5
                                                                        and Pax-
                                                                        8 show
                                                                        overlappin
                                                                        g
                                                                        expressio     condensin
                                                             a splice   n with the    g
                                                             variant is engrailed     mesenchy
                                                             Pax-2b     genes         me cells
                                                http://local [4] Pax-2 and bind       & their
                                                host/cgi- comprises as                epithelial
                                                bin/biobas a            activators    derivative
                  Pax-2,                        e/transfac/ remnant to the En-        s in the
                  PAX2,     mouse,              7.4/bin/get of a        25            developin
                  mPax2,    Mus      vertebrate TFProf.cgi homeo        enhancer      g kidney
T00678   Pax-2a   mPax-2.   musculus s          ?T00678 domain          [1]           [4]
                                                               independe    activator
                                                               nt DNA-      (fused to
                                                               binding      GAL4-
                                                               by paired    DNA           8.5-d
                                                               and          binding       embryos:
                                                               homeo        domain)       mitotic
                                                               domain       [14]          cells in
                                                               contacting   mutations     the
                                                                ATTA        may           ventricular
                                                               and          cause           zone of
                                                               GTTCC        Splotch       developin
                                                               motifs,      (pigmenta     g spinal
                                                               resp. [12]   tion          chord;
                                                               variable     abnormalit    some
                                                               spacing      ies in iris   regions in
                                                               of the       and hair,     hindbrain,
                                                               subsites     eye           midbrain,
                                                               [13]         displacem     diencepha
                                                               paired       ent,          lon; 10-
                                                               domain       exenceph      12-d
                                                               induces      aly, spina    embryos:
                                                               conformati   bifida,       neural
                                                               onal         lack of       crest of
                                                               change in    limb          developin
                                                               the DNA      musculatu     g spinal
                                                               [12]         re) [21]      ganglia,
                                                http://local   homodime     [19], e. g.   cranofacia
                                                host/cgi-      rization     G42R          l
                 HuP2                           bin/biobas     upon         [12] or       mesectod
                 (human),                       e/transfac/    DNA-         point         erm, limb
                 PAX3,      mouse,              7.4/bin/get    binding      mutation      mesenchy
                 mPax-3,    Mus      vertebrate TFProf.cgi     through      causing       me (10-
T00680   Pax-3   mPax3.     musculus s          ?T00680        residues     aberrant      11 d) [20]
                                                               Pax-4        homozygo
                                                               gene         us
                                                               presumabl    knockout
                                                               y exists     mice die
                                                               as a         after birth
                                                               single       within 3
                                                               copy in      days
                                                               the          showing        MIN6,
                                                               genome       growth         betaTC
                                                               [3] the      retardatio     and NIT-
                                                               activation   n and          1 cells
                                                               domain       dehydratio     [3];
                                                               seems to     n              (embryo
                                                               be E1A-      (apparentl     9.5 days:)
                                                               responsiv    y as a         ventral
                                                               e            conseque       spinal
                                                               whereas      nce of         cord,
                                                               the          insulin        pancreas,
                                                               repression   deficiency     (embryo
                                                                domain      ) [5]          10.5
                                                               is general   differentiat   days:)
                                                               active [1]   ion of         dorsal
                                                               three        endocrine      pancreas,
                                                               splice       progenitor     (embryo
                                                               variants     s to beta      11.0
                                                               found        and delta      days:)
                                                http://local   which        cells [5]      ventral
                                                host/cgi-      were not     Pax-4          pancres,
                                                bin/biobas     named by     binds to       (newborn:
                  PAX4,                         e/transfac/    the          islet          ) insulin-
                  mPAX4,    mouse,              7.4/bin/get    authors      hormone        producing
                  Pax-4,    Mus      vertebrate TFProf.cgi     [4] the C-   promoters      beta cells
T02983   Pax-4a   mPax-4.   musculus s          ?T02983        terminal                    [5]


                                                                       repressor
                                                                       of human
                                                                       insulin
                                                                       promoter
                                                                       by
                                                              93 and   binding
                                                              91.7%    the C2
                                                              identity element
                                                              with     [1]
                                                              murine   inhibitory
                                                 http://local Pax-4    activity on
                                                 host/cgi- nucleotide islet
                                                 bin/biobas and        amyloid             RIN (rat
                            rat,                 e/transfac/ amino     polypeptid          insulinom
                            Rattus               7.4/bin/get acid      e (IAPP)            a) cells,
                  PAX4,     norvegicu vertebrate TFProf.cgi sequence promoter              pancreatic
T03001   Pax-4a   Pax-4.    s         s          ?T03001 [2]           [1]                  islets [2]
                                                                               repressor
                                                                               of human
                                                                               insulin
                                                                               promoter
                                                                               by
                                                                               binding
                                                                               the C2
                                                                               element
                                                                               [1]
                                                                               inhibitory
                                                 http://local                  activity on
                                                 host/cgi-                     islet
                                                 bin/biobas                    amyloid       RIN (rat
                            rat,                 e/transfac/                   polypeptid    insulinom
                            Rattus               7.4/bin/get                   e (IAPP)      a) cells,
                  PAX4,     norvegicu vertebrate TFProf.cgi                    promoter      pancreatic
T03003   Pax-4c   Pax-4.    s         s          ?T03003                       [1]            islets [2]

                                                                 intact
                                                                 paired
                                                                 domain
                                                                 required
                                                                 for
                                                                 recognitio
                                                                 n of all
                                                                 Pax-5
                                                                 binding       regulator
                                                                 sites [2] a   of B cell
                  BSAP,                                          C-            developm
                  Pax-5, B-                                      terminally    ent [3]
                  cell                            http://local   truncated     tumor
                  specific                        host/cgi-      paired        initiation
                  activator                       bin/biobas     domain        by            (pro-, pre-
                  protein,                        e/transfac/    recognize     inhibiting    , mature
                  PAX5,     human,                7.4/bin/get    sa            the p53       B cells),
                  hPax5,    Homo       vertebrate TFProf.cgi     subset of     transcripti   astrocytic
T00070   Pax-5    hPax-5.   sapiens    s          ?T00070        sites [2]     on [1]        tumors [1]
                                                                           required
                                                                           for B-cell
                                                                           developm
                                                                           ent [5]
                                                                           represses
                                                                           Ig 3 alpha
                                                                           enhancer
                                                                           by
                                                                           preventing
                                                                            binding
                                                                           of an
                                                                           activator
                                                                           [3] also
                                                                           required
                                                                           for
                                                                           correct
                                                                           early
                                                            a few          developm
                                                            difference     ent of
                                                            s within       posterior
                                                            the paired     midbrain
                                                            domains        [5]
                                                            determine      expressio
                                                             different     n
                 BSAP,                                      DNA-           positively
                 Pax-5, B-                                  binding        regulated
                 cell                        http://local   sequence       by E2A
                 specific                    host/cgi-      specificitie   genes [4]
                 activator                   bin/biobas     s              Pax-2,
                 protein,                    e/transfac/    between        Pax-5
                 PAX5,     mouse,            7.4/bin/get    Pax-5          and Pax- (pro-, pre-
                 mPax5,    Mus    vertebrate TFProf.cgi     and Pax-       8 show     , mature
T01201   Pax-5   mPax-5. musculus s          ?T01201        6 [2]          overlappin B cells)
                                                                          heterozyg
                                                                          ous           (embryo
                                                                          mutations     8 days:)
                                                                          cause         surface-
                                                                          small eye     and
                                                                          (Sey) and     neuroecto
                                                                          die a few     derm
                                                                          minutes       [10];
                                                                          after birth   (embryo
                                                                          [13] [8]      8.5 days:)
                                                                          essential     forebrain
                                                                          role in the   and
                                                                          developm      spinal
                                                                          ent and       cord [15];
                                                                          function      (embryo
                                                                          of            9.0:)
                                                                          glucagon-     telenceph
                                                                          producing     alon,
                                                                          cells in      diencepha
                                                                          both          lon,
                                                                          pancreatic    neural
                                                                           and          tube,
                                                              the         intestinal    optic
                                                              expressio   endoderm      vesicle,
                                                              n of Pax-   al            pancreas
                                                              6 and       lineages      [8];
                 Pax-6,                        http://local   Vax-1 is    [3] lens-     (adult:)
                 Sey,                          host/cgi-      compleme    specific      lens,
                 PAX6,                         bin/biobas     ntary and   expressio     brain,
                 Small                         e/transfac/    exclusive   n of zeta-    pancreas
                 eye,      mouse,              7.4/bin/get    in the      crystallin    endocrine
                 mPax-6,   Mus      vertebrate TFProf.cgi     forebrain   [11] eye      cells [11]
T00681   Pax-6   mPax6.    musculus s          ?T00681        [6]         and nasal     [8]
                                                              Pax-8
                                                              contains
                                                              a
                                                              remnant     Pax-2,
                                                              of a        Pax-5
                                                              homeo       and Pax-
                                                              domain      8 show
                                                              there may   overlappin
                                                              be many     g
                                                              splice      expressio
                                                              variants    n with the
                                                              [2] Kr of   engrailed
                                                              Pax-8 to    genes
                                               http://local   the BS-I    and bind
                                               host/cgi-      and BS-II   as
                                               bin/biobas     site is     activators
                                               e/transfac/    3.33 Exp    to the En-
                 PAX8,     mouse,              7.4/bin/get    5 and       25
                 mPax-8,   Mus      vertebrate TFProf.cgi     0.32 Exp    enhancer
T01828   Pax-8   mPax8.    musculus s          ?T01828        5 [1]       [1]        NULL



                                                                     binds in a
                                                                     mutually
                                                                     exclusive
                                                                     manner
                                                                     with TTF-
                                                                     1 to some
                                                                     thyroid-
                                                                     specific
                                                                     promoters
                                                                      [3]
                                                                     activates
                                                                     preferenti
                                                                     ally
                                                http://local         thyroid        fetal:
                                                host/cgi-            peroxydas      thyroid
                                                bin/biobas there may e (TPO)        [1]; adult:
                           rat,                 e/transfac/ be many and             kidney,
                           Rattus               7.4/bin/get splice   thyroperox     thyroid
                           norvegicu vertebrate TFProf.cgi variants  ydase          [3]; TL5
T01829   Pax-8   PAX8.     s         s          ?T01829 [2]          (Tg) [3] [1]   cell line [3]
                                                                   there are
                                                                   many
                                                                   splice
                                                                   variants
                                                                   (Pax-8a
                                                                   to 8f) four
                                                    http://local   of themtumor
                                                    host/cgi-      (Pax-8ainitiation
                                                    bin/biobas     to -8d)by
                                                    e/transfac/    being  inhibiting
                   PAX8,      human,                7.4/bin/get    cloned the p53
                   hPax-8,    Homo       vertebrate TFProf.cgi            transcripti
                                                                   from man
T02898   Pax-8     hPax8.     sapiens    s          ?T02898        [2]    on [1]
                                                                          TCF-1P        NULL
                                                                          regulation
                                                                          might be
                                                                          regulated
                                                                          by APC
                                                                          and beta-
                                                                          catenin
                                                                          [1] due to
                                                                          the
                                                                          presence
                                                               most       of the
                                                               similar to Groucho
                                                               human      interacting
                                                               splice      domain
                                                               variant    this
                                                               TCF-1B     isoform
                                                               except a can act
                                                               31 AA      as a
                                                               insert     negative
                                                               after      regulator
                                                               residue    of Wnt
                                                               88 of the signalling
                                                               human      pathway
                                                               factor     [1] for
                                                               most       expressio
                                                               abundant n in teeth,
                                                  http://local isoform    see [2]
                  T cell                          host/cgi- lacking       cell
                  factor 1,                       bin/biobas an beta- specifity:
                  TCF-1,                          e/transfac/ catenin     T cells [5]
                  TCF-1P,     mouse,              7.4/bin/get interacting nucleus       see
                  TCF-7,      Mus      vertebrate TFProf.cgi domain       of            functional
T01109   TCF-1(P) TCF7.       musculus s          ?T01109 [1]             intestine     features
                                                                tripartite   activator
                                                                DNA-         [24] [17]
                                                                binding      may act
                                                                domain       synergistic
                                                                comprisin    ally when
                                                                g the        bound to
                                                                POUs         two
                                                                homology     distant
                                                                region       sites [17]
                                                                extended     involved
                                                                towards      in
                                                                the N-       hepatocyt
                                                                terminus     e-specific
                                                                (pos.        gene
                                                                113), the    expressio
                                                                homeo        n,
                                                                domain,      although
                                                                and the      not being
                                                                dimerizati   the sole
                                                                on           determina
                                                                domain       nt [18]
                                                                [21]         [12]
                                                                dimerizati   cooperate
                                                                on           s with
                                                                domain       other liver-
                                                                comprises    enriched
                                                http://local     a kinked    factors
                                                host/cgi-       alpha        such as        liver,
                 APF,                           bin/biobas      helix (7-    C/EBP,         intestine,
                 HNF1,     rat,                 e/transfac/     18 and       HNF-3,         spleen,
                 HNF-      Rattus               7.4/bin/get     23-32),      HNF-4          stomach,
                 1alpha,   norvegicu vertebrate TFProf.cgi      both         [12]           kidney
T00369   HNF-1   LF-B1.    s         s          ?T00369         helices in   expressed      [18]


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                                                 e/transfac/
                           chick,                7.4/bin/get
                           Gallus     vertebrate TFProf.cgi
T01952   HNF-1             gallus     s          ?T01952                                    NULL
                                                                 usage of
                                                                 an
                                                                 alternative
                                                                  poly(A)
                                                                 signal
                                                                 leads to      activator
                                                                 HNF-1B,       [5]
                                                                 whereas       synergistic
                                                                 an
                                                                 unspliced     interaction
                                                                 intron         with
                  APF,                                           introduces    C/EBPalp      liver,
                  HNF1,                           http://local    a new        ha [1]        intestine,
                  HNF-                            host/cgi-      stop          activator     spleen,
                  1alpha,                         bin/biobas     codon         of some       stomach,
                  LF-B1,                          e/transfac/    giving        intestine-    kidney;
                  TCF-1,    human,                7.4/bin/get    rise to       specific      cell lines
                  HNF-1A,   Homo       vertebrate TFProf.cgi     HNF-1C        promoters     (Caco
T00368   HNF-1A   HNF-1.    sapiens    s          ?T00368        [5]            [2] [3]      cells) [2]
                                                                 factor
                                                                 formerly
                                                                 designate
                                                  http://local   d as LF-
                                                  host/cgi-      B1 and
                                                  bin/biobas     suppleme
                                                  e/transfac/    ntary
                            domestic              7.4/bin/get    identified
                            pig, Sus   vertebrate TFProf.cgi     as HNF-       activator
T01180   HNF-1A   LF-B1.    scrofa     s          ?T01180        1A [2] [1]    [1]           NULL
                                                                   glycosylati
                                                                   on similar
                                                                   factor in
                                                                   lung: 110
                                                                   + 120
                                                                   kDa
                                                                   (SDS)
                                                                   dimerizes
                                                                   in the
                                                                   absence
                                                                   of DNA
                                                                   [5]
                                                                   unusual
                                                                   for
                                                                   homeobox
                                                                    genes,
                                                                   gene
                                                   http://local    regions       induced
                  APF,                             host/cgi-       encoding      in F9
                  HNF1,                            bin/biobas      helix 2       cells by   liver,
                  HNF-                             e/transfac/     and 3 are     RA,        intestine,
                  1alpha,      mouse,              7.4/bin/get     separated     plateau    spleen,
                  LF-B1,       Mus      vertebrate TFProf.cgi       by an        after 5d   stomach,
T01211   HNF-1A   HNF-1A.      musculus s          ?T01211         intron [2]    [4]        kidney

                                                                                 activator,
                                                                                 may
                                                                                 modulate
                                                                                 the
                                                                                 activity of
                                                                                 HNF-1 [1]
                                                                                 predomin
                                                                                 antly
                                                                                 found in
                                                                                 dedifferen
                                                                                 tiated
                                                                                 hepatoma
                                                                                  cells [6]
                                                                                 expressed
                                                                                  in
                                                                                 several
                                                                                 endoderm
                  HNF-                              http://local                 al and
                  1beta, LF-                        host/cgi-                    mesoder
                  B3                                bin/biobas                   mal
                  (mouse),     rat,                 e/transfac/                  embryonal
                  TCF-2,       Rattus               7.4/bin/get                   tissues
                  vHNF-1,      norvegicu vertebrate TFProf.cgi                   before
T00889   HNF-1B   vHNF1.       s         s          ?T00889                      HNF-1 [5] NULL
                                                                                          kidney,
                                                                                          lung,
                                                                                          (liver,
                                                                                          ovary,
                                                                                          intestine,
                                                                                          stomach:
                                                                              induced     weak
                                                http://local                  in F9       mRNA-
                                                host/cgi-                     cells by    signal),
                  LF-B3,                        bin/biobas                    retinoic    epithel of
                  TCF-2,                        e/transfac/                   acid,       endo-
                  vHNF-1,   mouse,              7.4/bin/get                   max.        and
                  LFB3,     Mus      vertebrate TFProf.cgi                    after 24    mesoder
T00890   HNF-1B   vHNF1.    musculus s          ?T00890                       hours [3]   mal origin
                                                                usage of
                                                                an
                                                                alternative
                                                                 poly(A)
                                                                signal
                                                                leads to
                                                                HNF-1A,
                                                                whereas
                                                                an
                                                                unspliced
                                                                intron
                                                                introduces
                                                 http://local    a new
                                                 host/cgi-      stop          activator,
                                                 bin/biobas     codon         5-fold
                                                 e/transfac/    giving        more
                            human,               7.4/bin/get    rise to       potent     cell lines
                  HNF-      Homo      vertebrate TFProf.cgi     HNF-1C        than HNF- (Caco
T01950   HNF-1B   1beta.    sapiens   s          ?T01950        [3]           1A [3]     cells) [1]
                                                                       activator,
                                                                       5-fold
                                                                       more
                                                                       potent
                                                                       than HNF-
                                                                       1A [2]
                                                                       mRNA
                                                                       levels are
                                                                       about 4-
                                                                       11% of
                                                                       HMF-1A
                                                              usage of mRNA
                                                 http://local an       ecept
                                                 host/cgi- alternative fetal and
                                                 bin/biobas poly(A)    adult
                                                 e/transfac/ signal    kidney
                           human,                7.4/bin/get leads to  (86% and
                           Homo       vertebrate TFProf.cgi HNF-1A 27%,
T01951   HNF-1C            sapiens    s          ?T01951 [2]           resp.) [2] NULL


                                                 http://local
                                                 host/cgi-
                  LF-B3,                         bin/biobas
                  vHNF-1,                        e/transfac/
                  LFB3,    domestic              7.4/bin/get
                  vHNF-1A, pig, Sus   vertebrate TFProf.cgi
T01955   vHNF-1   vHNF1.   scrofa     s          ?T01955                                NULL
                                                                splice
                                                                variant
                                                                vHNF-1B
                                                                exhibits
                                                                an
                                                                internal
                                                                deletion,
                                                                variant      activator,
                                                                vHNF-1C      higher
                                                                lacks the    activity
                                                                C-           and
                                                 http://local   terminal     higher
                                                 host/cgi-      part due     DNA-
                                                 bin/biobas     to usage     binding
                 HNF-                            e/transfac/    of           affinity
                 1beta,   human,                 7.4/bin/get    another      than
                 vHNF-1, Homo         vertebrate TFProf.cgi     poly(A)      vHNF-1B
T00891   vHNF-1A vHNF-1A. sapiens     s          ?T00891        signal [1]   [2]        liver, lung
                                                       splice
                                                       variant
                                                       vHNF-1A
                                                       exhibits
                                                       an
                                                       insertion
                                                       after
                                                       position
                                                       182,
                                                       variant      activator,
                                                       vHNF-1C      lower
                                                       lacks the    activity
                                                       C-           and
                                        http://local   terminal     higher
                                        host/cgi-      part due     DNA-
                                        bin/biobas     to usage     binding
                                        e/transfac/    of           affinity
                   human,               7.4/bin/get    another      than
                   Homo      vertebrate TFProf.cgi     poly(A)      vHNF-1A
T01953   vHNF-1B   sapiens   s          ?T01953        signal [1]   [2]        liver, lung


                                                               transdomi
                                                               nant
                                                               repressor,
                                                                relative
                                                               level
                                                               compared
                                                                with
                                                     splice    variant A
                                                     variant   varies in
                                                     vHNF-1B different
                                                     exhibits  tissues
                                                     an        between
                                                     internal  4.7% and
                                                     deletion, 43.5%,
                                                     variant   the
                                                     vHNF-1A highest
                                                     has an    relative
                                                     extended concentrat
                                                     C-        ions
                                        http://local terminal  found in
                                        host/cgi- part due fetal and
                                        bin/biobas to usage adult
                                        e/transfac/ of         kidney
                   human,               7.4/bin/get another    (43.5 and
                   Homo      vertebrate TFProf.cgi poly(A)     40%,
T01954   vHNF-1C   sapiens   s          ?T01954 signal [1] resp.) [1] liver, lung
                                                                binds to
                                                                DNA as a
                                                                homotetra
                                                                mer, in
                                                                solution is
                                                                primarily
                                                                a dimer
                                                                [3]
                                                                belongs
                                                                to the
                                                                Granyhea
                                                                d-like
                                                                family of
                                                                TFs,          activator
                                                                together      activates
                                                                with          transcripti
                                                                Drosophil     on of
                                                                a Elf-        SV40 late
                                                                1/NTF-1       promoter
                                                                factors,      [11]
                                                                and likely    genetic
                                                                presents      determina
                                                                novel         nt of
                                                                type of       Alzheimer
                 alpha-                                         DNA           s disease
                 CP2a,                                          binding       [2]
                 CP-2,                           http://local   [3]           biallelic
                 LSF,                            host/cgi-      recognize     polymorph
                 alpha-                          bin/biobas     s DNA         ism, A-
                 CP2, LBP-                       e/transfac/    elements      >G,
                 1c, Late  human,                7.4/bin/get    consisting    influences
                 SV40      Homo       vertebrate TFProf.cgi      of two        the risk
T00151   CP2     factor.   sapiens    s          ?T00151        directly      of AD [2]. NULL


                                                http://local
                                                host/cgi-                               adult
                                                bin/biobas                              thymus,
                 growth    rat,                 e/transfac/                             splenocyt
                 factor    Rattus               7.4/bin/get                             es,
                 independe norvegicu vertebrate TFProf.cgi                    repressor spleen,
T01921   Gfi-1   nce 1.    s         s          ?T01921                       [2]       testis [2]
                                                                  alternative   transcripti
                                                                   splice       onal
                                                                  variants      activator
                                                                  [7] the       in the pol
                                                                  bipartite     II [64] and
                                                                  DNA-          in the pol
                                                                  binding       III system
                                                                  (POU)         [57] also
                                                                  domain        part of
                                                                  comprises     the
                                                                   a POU-       replication
                                                                  specific
                                                                  (POUs)        machinery
                                                                  and a          of
                                                                  POU           adenoviru
                                                                  homeo         s [71] for
                                                                  (POUh)        stimulatio
                                                                  domain        n of
                                                                  [67] the      replication
                  (Ig)NF-A,                                       homeo         , the DNA-
                  alpha-H1,                                       domain        binding
                  NF-A1,                                          contains      domain
                  NF-III,                                         a             (whole
                  OBP100,                                         recogniza     POU
                  Oct-1,                                          ble helix-    domain)
                  octamer-                                        turn-helix    is
                  binding                          http://local   motif [63]    required
                  factor,                          host/cgi-      [67] [4]      (POUs is
                  oct-B1A,                         bin/biobas     the POU-      inert,
                  oct-B1B,                         e/transfac/    specific      POUh
                  OTF-1,    human,                 7.4/bin/get    domain        inhibitory)
                  TRF, Oct- Homo        vertebrate TFProf.cgi     comprises     and         ubiquitous
T00641   POU2F1   1B.       sapiens     s          ?T00641         4 alpha-     sufficient [63]

                  (Ig)NF-A,
                  alpha-H1,
                  NF-A1,
                  NF-III,
                  OBP100,
                  Oct-1,
                  octamer-                         http://local
                  binding                          host/cgi-
                  factor,                          bin/biobas
                  oct-B1A,    clawed               e/transfac/
                  oct-B1B,    frog,                7.4/bin/get
                  OTF-1,      Xenopus   vertebrate TFProf.cgi
T00642   POU2F1   TRF.        laevis    s          ?T00642                                    (kidney)
                                                   http://local
                                                   host/cgi-            differential
                                                   bin/biobas
                              rat,                 e/transfac/          phosphory
                              Rattus               7.4/bin/get          lation
                              norvegicu vertebrate TFProf.cgi phosphory during
T00643   POU2F1   Oct-1.      s         s          ?T00643 lation       cell cycle NULL
                  alpha-H1,
                  IgNF-A,
                  NF-A, NF-
                  A1, NF-
                  III,
                  OBP100,
                  Oct-1,
                  octamer-                         http://local
                  binding                          host/cgi-
                  factor,                          bin/biobas
                  oct-B1A,    monkey,              e/transfac/
                  oct-B1B,    Cercopith            7.4/bin/get
                  OTF-1,      ecus      vertebrate TFProf.cgi
T00959   POU2F1   TRF.        aethiops s           ?T00959                       ubiquitous
                  alpha-H1,
                  IgNF-A,
                  NF-A, NF-
                  A1, NF-
                  III,
                  OBP100,
                  Oct-1,
                  octamer-                          http://local
                  binding                           host/cgi-
                  factor,                           bin/biobas
                  oct-B1A,                          e/transfac/
                  oct-B1B,    chick,                7.4/bin/get
                  OTF-1,      Gallus     vertebrate TFProf.cgi
T01031   POU2F1   TRF.        gallus     s          ?T01031                      NULL


                                                   http://local
                                                   host/cgi-
                                                   bin/biobas
                              gibbon               e/transfac/
                              ape,                 7.4/bin/get
                  Oct-1,      Hylobates vertebrate TFProf.cgi
T01157   POU2F1   OTF-1.      lar       s          ?T01157                       NULL
                                                                              DNA-
                                                                              binding is
                                                                              reduced
                                                                              by GR in
                                                                              a ligand-
                                                                              dependent
                                                                               manner
                                                                              interaction
                                                                               with HSV
                                                                              VP16
                                                   http://local               directs
                                                   host/cgi-                  Oct-1
                                                   bin/biobas     homeo       preferably
                                                   e/transfac/    domain      to the
                             hamster,              7.4/bin/get    essential TAATGA
                             Cricetulus vertebrate TFProf.cgi     for GR      RAT
T01466   POU2F1               griseus   s          ?T01466        at least 3 motif [2] NULL
                                                                  interaction
                                                                  splice
                                                                  variants
                                                                  are
                                                                  encoded
                                                                  by the
                                                                  murine
                                                                  oct-1
                                                                  gene [2]
                                                                  compared
                                                                   to the
                                                                  human
                                                                  homolog,
                                                                  mouse
                                                                  Oct-1
                                                                  exhibits
                                                                  four AA
                                                                  exchange
                                                                  s within
                 alpha-H1,                                        helix 1
                 IgNF-A,                                          and 2
                 NF-A, NF-                                        making
                 A1, NF-                                          its
                 III,                                             sequence
                 OBP100,                                          more
                 Oct-1,                                           similar to DNA-
                 octamer-                      http://local       (human) binding is
                 binding                       host/cgi-          Oct-2 and reduced
                 factor,                       bin/biobas         thus        by GR in
                 oct-B1A,                      e/transfac/        causing a a ligand-
                 oct-B1B, mouse,               7.4/bin/get        much        dependent
                 OTF-1,    Mus      vertebrate TFProf.cgi         weaker       manner ubiquitous
T00644   POU2F1a TRF.      musculus s          ?T00644            interaction [4]         [9]
                                                      conflict     Evi-1
                                                      between      antagoniz
                                                      EMBL         es in
                                                      entry        TGF-beta
                                                      #AB00493     signaling
                                                      0 and        by
                                                      EMBL         quenching
                                                      entry         Smad-3
                                                      #U68019,     [11] the
                                                      in which     first zinc
                                                      an aa-       finger
                                                      sequence     domain
                                                      of 425       Evi-1 is
                                                      AAs in       essential
                                                      lenghth is   for the
                                                      described    interaction
                                                      based on      with
                                                      RNA in       Smad-3,
                                                      contrast     whereas
                                                      to the one   the MH2
                                                      based on     domain of
                                                      DNA in       Smad-3
                                                      EMBL         is
                                                      #AB00493     essential
                                                      0 from       for the
                                                      AA 178       interaction
                                       http://local   an            with Evi-
                                       host/cgi-      insertion    1 [11] it is
                                       bin/biobas     of 10 AAs    indicated
                                       e/transfac/    (VGTWA       that Evi-1
                  human,               7.4/bin/get    AQAGL)       abrogates
                  Homo      vertebrate TFProf.cgi     is            the
T04096   SMAD-3   sapiens   s          ?T04096        described    interaction NULL


                                      http://local
                                      host/cgi-
                                      bin/biobas
                  zebra               e/transfac/
                  fish,               7.4/bin/get
                  Brachyda vertebrate TFProf.cgi
T04149   SMAD-3   nio rerio s         ?T04149                                NULL
                                                              -/- mice
                                                              are
                                                              smaller
                                                              than wild-
                                                              type
                                                              littermates
                                                               [4] [5]
                                                              some
                                                              have an
                                                              incomplet
                                                              ely
                                                              penetrant
                                                              forepaw
                                                              defect,       (embryo):
                                                              torqued       throughou
                                                              hind          t
                                                              limbs,        embryonic
                                                              kyphosis
                                                              or display    developm
                                                              marked        ent [4];
                                                              rib cage      (adult):
                                                              malformati    bone
                                                              on and        marrow,
                                                              die           heart,
                                                              between       brain,
                                                              1 and 8       kidney
                                      http://local            months        [4]; lung,
                                      host/cgi-               [5] death     spleen,
                                      bin/biobas              of -/-        thymus
                                      e/transfac/             mice          [4] [5];
                  mouse,              7.4/bin/get             between       pituitary
                  Mus      vertebrate TFProf.cgi              1 and 8       gonadotro
T04210   SMAD-3   musculus s          ?T04210                 months        pes [1]


                                        http://local
                                        host/cgi-
                                        bin/biobas
                                        e/transfac/
                  chick,                7.4/bin/get partial
                  Gallus     vertebrate TFProf.cgi cDNA
T04248   SMAD-3   gallus     s          ?T04248 sequence                    NULL


                                        http://local
                                        host/cgi-
                                        bin/biobas
                                        e/transfac/
                  domestic              7.4/bin/get
                  pig, Sus   vertebrate TFProf.cgi
T04251   SMAD-3   scrofa     s          ?T04251                             NULL
                                                      C-
                                                      terminal
                                                      region
                                                      (MH2
                                                      domain)
                                                      and
                                                      conserved
                                                       glycin
                                                      residue
                                                      (AA 379)
                                                      in L3
                                                      loop,
                                                      which is
                                                      proposed
                                                      to be
                                                      involved
                                                      in protein-
                                                      protein
                                                      interaction
                                                      , are
                                                      required
                                                      for the
                                                      self-
                                                      stimulator
                                                      y activtity
                                                      [2] MH1
                                       http://local   domain
                                       host/cgi-      and four
                                       bin/biobas     lysin
                  rat,                 e/transfac/    residues
                  Rattus               7.4/bin/get    at
                  norvegicu vertebrate TFProf.cgi     positions
T04431   SMAD-3   s         s          ?T04431        40, 41, 43 NULL
                                                      the C-
                                                      terminal      expressed
                                                      zinc           at time
                                                      finger        and place
                                                      plus the      of heart
                                                      adjacent      developm
                                                      basic         ent [2]
                                                      domain        required
                                                      (251-324)     for
                                                      are           cardiac
                                                      necessary     muscle-
                                                       and          specific
                                                      sufficient    gene
                                                      for DNA-      expressio
                                                      binding       n in
                                                      [4] the       DMSO-
                                                      region        treated
                                                      around        P19 cells
                                                      the C-        [5]
                                                      terminal      ectopic
                                                      zinc          expressio
                                                      finger        n can
                                                      (251-324)     rescue
                                                      also          erythroid
                                                      contains      differentiat
                                                      a nuclear     ion of
                                      http://local    localizatio   GATA-1
                                      host/cgi-       n signal      <T00305>
                                      bin/biobas      [4] N- and     deficient
                                      e/transfac/     C-            murine
                  mouse,              7.4/bin/get     terminal      embryonic
                  Mus      vertebrate TFProf.cgi      sequence       stem
T02532   GATA-4   musculus s          ?T02532         s are         cells [6]    NULL


                                                                               adult:
                                                                               (highest:)
                                                                               heart,
                                                                               (lower:)
                                       http://local                            ovary and
                                       host/cgi-                               small
                                       bin/biobas                   transcribe intestine
                                       e/transfac/                  d during [2];
                  chick,               7.4/bin/get                  heart      embryonic
                  Gallus    vertebrate TFProf.cgi                   developm : (mainly:)
T02682   GATA-4   gallus    s          ?T02682                      ent [2]    heart [2]
                                                  http://local
                                                  host/cgi-
                                                  bin/biobas
                                                  e/transfac/
                            human,                7.4/bin/get                                 (Caco-2
                            Homo       vertebrate TFProf.cgi                                  <0239>
T02687   GATA-4             sapiens    s          ?T02687                                     [3])


                                                  http://local
                                                  host/cgi-
                                                  bin/biobas
                            clawed                e/transfac/
                            frog,                 7.4/bin/get
                            Xenopus    vertebrate TFProf.cgi
T02711   GATA-4             laevis     s          ?T02711                                     NULL
                                                                               up-
                                                                               regulated
                                                                               in
                                                                               cardiomyo
                                                                               cytes
                                                 http://local                  after
                                                 host/cgi-       two           treatment      heart
                                                 bin/biobas      different     with           (cardiomy
                            rat,                 e/transfac/     sequence      triidothyro    ocytes),
                            Rattus               7.4/bin/get     s             nine or        testis,
                  GATA-     norvegicu vertebrate TFProf.cgi      published     retinoic       ovary [1]
T02716   GATA-4   GT2.      s         s          ?T02716         [5] [1]       acid [2]       [3]
                                                                               associate
                                                                               d with
                                                                               t(11
                                                                               14)(p13
                                                                               q11)
                                                                               translocati
                                                                               ons in T
                                                                 specificall   cell
                                                  http://local   y             leukemias
                  LIM-only                        host/cgi-      interacts      [1]
                  protein 2,                      bin/biobas     with Tal-1    essential
                  RBTN2,                          e/transfac/    in            for
                  Rhomboti human,                 7.4/bin/get    erythroid     erythroid
                  n-2, TTG- Homo       vertebrate TFProf.cgi     cells [2]     differentiat
T02250   Lmo2     2.         sapiens   s          ?T02250        [3]           ion [1]        NULL
                                                                specificall
                                                                y
                                                                interacts
                                                                with Tal-1
                                                                in
                                                                erythroid     important
                                                                cells [3]     for
                                                                [4]           erythropoi
                                                                interacts     esis [2]
                                                                with          may form
                                                                GATA-1in      a bridge
                                                                erythroid     in high
                                                http://local    cells, LIM    order
                 LIM-only                       host/cgi-       domain        complex
                 protein 2,                     bin/biobas      may be        that
                 RBTN2,                         e/transfac/     responsibl    comprises
                 Rhomboti mouse,                7.4/bin/get     e for this     GATA-1,
                 n-2, TTG- Mus       vertebrate TFProf.cgi      interaction   Tal-1 and
T02251   Lmo2    2.         musculus s          ?T02251          [2] [1]      E47 [2]    NULL


                                                 http://local
                 HNF-                            host/cgi-      full length            brain,
                 3/Fkh                           bin/biobas     sequence               heart,
                 Homolog    rat,                 e/transfac/    has not                intestine,
                 2, HFH2,   Rattus               7.4/bin/get    been                   kidney,
                 Genesis,   norvegicu vertebrate TFProf.cgi     identified             liver, lung
T02290   FOXD3   HFH-2.     s         s          ?T02290        so far [4]             [4]
                                                                expressio
                                                                n pattern                   (embryo
                                                                discrepan                   6.5-7.5
                                                                cy: in                      d.:)
                                                                reference                   ubiquitous
                                                                [2]                         , (8.5-9.0
                                                                expressio                   d.:)
                                                                n was                       cranial
                                                                only                        neural
                                                                detected                    crest,
                                                                in                          rhombom
                                                                embryonic                   ere 4,
                                                                 stem                       roofplate,
                                                                cells                       neuroepith
                                                                whreres                     elium,
                                                                reference                   (9.5 d.:)
                                                                [1]                         cranial
                                                                observed                    sensory
                                                                complex                     ganglia,
                                                                embryonic                   lens
                                                                                            placode,
                                                                expressio                   neural
                                                                n            transcripti    tube,
                                                                patterns     onal           neural
                                                                in the       repressor      crest,
                                                                neural       with           sympathet
                                                http://local    crest fork   regulatory     ic gut
                                                host/cgi-       head         activity in    ganglia,
                                                bin/biobas      domain is    early          (10.5-
                                                e/transfac/     identical    embryonic      12.5 d.:)
                 HFH2,      mouse,              7.4/bin/get     to rat                      neural
                 Genesis,   Mus      vertebrate TFProf.cgi      FOXD3        differentiat   crest
T04166   FOXD3   HFH-2.     musculus s          ?T04166         <T02290>     ion [2]        cells [1]


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                                                 e/transfac/
                            human,               7.4/bin/get
                            Homo      vertebrate TFProf.cgi
T04167   FOXD3              sapiens   s          ?T04167                                    NULL
                  CBF(2),
                  CBF-A +
                  CBF-B,
                  CCAAT-
                  binding                                        consists
                  factor,                                        of three
                  CP1, NF-                        http://local   subunits:
                  Y                               host/cgi-      CBF-A
                  (mouse),                        bin/biobas     <T00087>
                  NF-        rat,                 e/transfac/    , CBF-B
                  YA:NF-     Rattus               7.4/bin/get    <T00088>
                  YB:NF-     norvegicu vertebrate TFProf.cgi     , CBF-C
T00084   CBF(2)   YC.        s         s          ?T00084        <T01595>               NULL


                                                  http://local
                  CBF-A,                          host/cgi-
                  CP1-A,                          bin/biobas
                  HAP3       rat,                 e/transfac/
                  (yeast),   Rattus               7.4/bin/get
                  NF-YB      norvegicu vertebrate TFProf.cgi
T00087   CBF-A    (mouse).   s         s          ?T00087                               NULL
                                                                 both the
                                                                 Gln- and
                                                                 the Ser-
                                                                 /Thr-rich
                                                                 region
                                                                 contribute
                                                                 to the
                                                                 transcripti
                                                                 onal
                                                                 activation    activator
                                                                 by CBF-       [2],
                                                                 B, each       contribute
                                                                 per se        s to the
                                                                 modestly      activation
                                                                 activating    potential
                                                  http://local   [2] trans-    of the
                  CBF-B,                          host/cgi-      activation    whole
                  CP1-B,                          bin/biobas     activity in   CBF
                  HAP2       rat,                 e/transfac/    whole         multimeric
                  (yeast),   Rattus               7.4/bin/get    CBF            factor
                  NF-YA      norvegicu vertebrate TFProf.cgi     redundant     complex
T00088   CBF-B    (mouse).   s         s          ?T00088         [2]          [2]        NULL
                                                                N-
                                                                terminal
                                                                part is
                                                                enriched
                                                                in
                                                                charged
                                                                residues
                                                                C-
                                                                terminal
                                                                150 AA:
                                                                enriched
                                                                in
                                                                hydrophob
                                                                ic and
                                                                glutamine
                                                                residues
                                                                subunit of
                                                                CP1/CBF
                                                                [2]
                                                                subcompl
                                                                ex with
                                                                CBF-A
                                                                which is
                                                                recognize
                                                                d by CBF-
                                                 http://local   B [2]
                                                 host/cgi-      CCAAT-
                                                 bin/biobas     binding
                 NF-YC      rat,                 e/transfac/    complex      no DNA-
                 (mouse),   Rattus               7.4/bin/get    with yeast   binding
                 CP1C       norvegicu vertebrate TFProf.cgi     HAP2/HA      by its own
T01595   CBF-C   (human).   s         s          ?T01595        P3 [2]       [2]        ubiquitous
                                                                three
                                                                subunits:
                                                                CP1A
                                                                <T00154>
                                                                , CP1B
                                                                <T01804>
                                                                 and       activator
                                                                CP1C       important
                                                                <T02478> regulator
                                                                           of MHC
                                                                previously class II
                                                                 was       gene
                                                                thought to transcripti
                                                                be         on binds
                                                                composed to X-Y-
                                                                 of seven boxes
                                                                polypeptid cooperativ
                                                                es of      ely with
                                                                three      the RFX
                                                                groups     complex
                                                                observed: <T05444>
                                                                alpha (35 ,
                                                                kDa),      stabilizes
                                                                beta (28, binding of
                                                                27 kDa), the RFX,
               alpha-                                           gamma      activates
               CP1,                              http://local   (33, 34,   transcripti
               CBF,                              host/cgi-      37, 38     on
               CP1, NF-                          bin/biobas     kDa)       synergistic
               Y, trimer                         e/transfac/    stable     ally with
               NF-Y, NF- human,                  7.4/bin/get    alpha:beta the RFX
               Y         Homo         vertebrate TFProf.cgi                complex
T00150   CP1   complex. sapiens       s          ?T00150        associatio [1].        NULL


                                             http://local
                         chinese             host/cgi-
                         hamster,            bin/biobas
                         Cricetulus          e/transfac/
                                             7.4/bin/get
               CP1, NF- longicaud vertebrate TFProf.cgi
T01171   CP1   Y.       atus      s          ?T01171                                 NULL
                                                                          as a
                                                                          subunit of
                                                                          the NF-Y
                                                                          complex,
                                                                          interacts
                                                                          directly
                                                                          with
                                                                          CIITA
                                                                          <T05450>
                                                               subunit of [2]
                                                               a trimeric interacts
                                                               DNA        directly
                                                               binding    with
                                                  http://local complex RFX5
                CBF-A                             host/cgi- NF-           subunit
                (rat), CP1-                       bin/biobas YA:NF-       <T01672>
                A, HAP3                           e/transfac/ YB:NF-       of the
                (yeast),    human,                7.4/bin/get YC, see     RFX
                NF-YB       Homo       vertebrate TFProf.cgi <T00150> complex
T00154   CP1A   (mouse). sapiens       s          ?T00154 .               [1].       (HeLa)

                                                                          as a
                                                                          subunit of
                                                                          the NF-Y
                                                                          complex,
                                                                          interacts
                                                                          directly
                                                                          with
                                                                          CIITA
                                                                          <T05450>
                                                                           [2]
                                                                          interacts
                                                                          directly
                                                               subunit of with two
                                                               a trimeric subunits
                                                               DNA        of the
                                                               binding    RFX
                                                  http://local complex complex,
                                                  host/cgi- NF-           RFX5
                CBF-C                             bin/biobas YA:NF-       <T01672>
                (rat), NF-                        e/transfac/ YB:NF-       and
                YC           human,               7.4/bin/get YC, see     RFXANK
                (mouse),     Homo      vertebrate TFProf.cgi <T00150> <T05441>
T02478   CP1C   HSM-1.       sapiens   s          ?T02478 .                [1].      ubiquitous
                                                               consists
                                                               of 3
                                                               subunits:
                                                               NF-YA
                                                               <T00615>
                                                               , NF-YB
                                                               <T00616>
                                                               , and NF-
                                                               YC
                                                               <T02477>

                                                               previously
                                                                was
                                                               thought to
                                                               be
                                                               composed
                                                                of seven
                                                               polypeptid
                 alpha-                                        es of
                 CP1,                                          three
                 CBF(2),                                       groups
                 CCAAT-                                        observed:
                 binding                                       alpha (35
                 factor,                                       kDa),
                 CP1, CP1                                      beta (28,
                 (human,                                       27 kDa),
                 rat), NF-                     http://local    gamma
                 Y, NF-YA                      host/cgi-       (33, 34,
                 + NF-YB,                      bin/biobas      37, 38
                 NF-                           e/transfac/     kDa)       activator
                 YA:NF-    mouse,              7.4/bin/get     stable     required
                 YB:NF-    Mus      vertebrate TFProf.cgi      alpha:beta for
T00613   NF-Y    YC.       musculus s          ?T00613                    reinitiation NULL


                                                http://local
                                                host/cgi-
                                                bin/biobas
                                                e/transfac/
                            mouse,              7.4/bin/get
                            Mus      vertebrate TFProf.cgi
T00614   NF-Y    NF-Y .     musculus s          ?T00614                                 NULL

                 CBF-B
                 (rat),                         http://local
                 CP1B                           host/cgi-      (all          binds to
                 (human,                        bin/biobas     features      Y-box
                 rat),                          e/transfac/    for 346       elements
                 HAP2       mouse,              7.4/bin/get    AA form)      of MHC
                 (yeast),   Mus      vertebrate TFProf.cgi     glutamine-    class II
T00615   NF-YA   NF-YA.     musculus s          ?T00615        rich region   genes      NULL
                                                                subunit of
                                                                a trimeric    as a
                                                                DNA           subunit of
                                                                binding       the NF-Y
                 CBF-B                                          complex       complex,
                 (rat), CP1-                                    NF-           interacts
                 B, HAP2,                                       YA:NF-        directly
                 HAP2                                           YB:NF-        with two
                 (yeast),                                       YC, see       subunits
                 NF-YA                                          <T00150>      of the
                 (mouse),                                        physical     RFX
                 CP1B,                           http://local   interaction   complex,
                 NFYA,                           host/cgi-       (in vitro    RFX5
                 CAAT-                           bin/biobas     and in        <T01672>
                 box DNA                         e/transfac/    vivo) with     and
                 binding     human,              7.4/bin/get    ZHX1          RFXANK (cell
                 protein     Homo     vertebrate TFProf.cgi     <T04355>      <T05441> lines:)
T01804   NF-YA   subunit A. sapiens   s          ?T01804         [2]           [1].      HeLa


                 CBF-A
                 (rat),                         http://local    subunit of
                 CP1a                           host/cgi-       the NF-Y      binds to
                 (human,                        bin/biobas      trimeric      Y-box
                 rat),                          e/transfac/     transcripti   elements
                 HAP3       mouse,              7.4/bin/get     on factor,    of MHC
                 (yeast),   Mus      vertebrate TFProf.cgi      see           class II
T00616   NF-YB   NF-YB.     musculus s          ?T00616         <T00613>      genes      NULL


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                                                 e/transfac/
                            clawed               7.4/bin/get
                            frog,     vertebrate TFProf.cgi
T05215   NF-YB              Xenopus   s          ?T05215                                 NULL


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                                                 e/transfac/
                            chick,               7.4/bin/get
                            Gallus    vertebrate TFProf.cgi
T05216   NF-YB              gallus    s          ?T05216                                 NULL
                                                                   forms the
                                                                   NF-Y
                                                                   factor
                                                                   complex
                                                                   <T00613>
                                                   http://local     together
                                                   host/cgi-       with NF-
                                                   bin/biobas      YA
                   CBF-C                           e/transfac/     <T00615>
                   (rat),      mouse,              7.4/bin/get      and NF-
                   CP1C        Mus      vertebrate TFProf.cgi      YB
T02477   NF-YC     (human).    musculus s          ?T02477         <T00616> transcripti    ubiquitous
                                                                             onal
                                                                             activator
                                                                             [4] [5] [6]
                                                                             [1] may
                                                                             be
                                                                             antagoniz
                                                                             ed by
                                                                             ARP-1
                                                                             and/or
                                                                             COUP-
                                                                             TF [7] [5]
                                                                             first step
                                                                             of
                                                                             activation
                                                                             by HNF-4
                                                                             appears
                                                                             to involve
                                                                             recruitme
                                                                             nt of
                                                                             TFIIB, a
                   HNF4,                                                     second
                   HNF-4,                                                    step
                   hepatocyt                                                 operates
                   e nuclear                                                 through
                   factor 4,                                                 the AF-2-
                   hepatocyt                        http://local             homologo
                   e nuclear                        host/cgi-                us
                   factor                           bin/biobas               activation
                   4alpha1,    rat,                 e/transfac/              domain
                   NR2A1,      Rattus               7.4/bin/get    forms     [4] can       liver,
         HNF-      ARE         norvegicu vertebrate TFProf.cgi     homodime act as         kidney,
T00372   4alpha1   protein.    s         s          ?T00372        rs.       transcripti   intestine
                                                                 the
                                                                 originally
                                                                 published
                                                                 465-AA
                                                                 sequence
                                                                 may lack
                                                                 9 N-
                                                  http://local   terminal
                   hepatocyt                      host/cgi-      amino
                   e nuclear                      bin/biobas     acid
                   factor                         e/transfac/    residues
                   4alpha2, human,                7.4/bin/get    of the                 liver,
         HNF-      HNF-4B, Homo        vertebrate TFProf.cgi     authentic activator    kidney,
T00373   4alpha2   NR2A1.    sapiens   s          ?T00373        protein [1] [1]        intestine


                                                                 androgen
                                                                 exposure
                                                                 required
                                                                 for
                                                                 dimerizati
                                                                 on and
                                                                 subseque
                                                                 nt DNA-
                                                                 binding
                                                                 dimerizati
                                                                 on
                                                                 inhibited
                                                                 by region
                                                                 A/B [5]
                                                                 nuclear
                                                                 uptake
                                                                 may
                                                                 occur         by
                                                                 constitutiv   binding to
                                                                 ely [9] as    androgen-
                                                                 well as       responsiv
                                                                 hormone-      e
                                                                 dependent     elements,
                   androgen                       http://local    [10] [4]     AR
                   receptor,                      host/cgi-      there may     regulates
                   AR,                            bin/biobas     be tissue-    expressio
                   NR3C4,                         e/transfac/    specific      n of
                   dihydrotes human,              7.4/bin/get    splice        target
                   tosterone Homo      vertebrate TFProf.cgi     variants      genes [8]
T00040   AR        receptor. sapiens   s          ?T00040        [11]          [5]        NULL
                                                                         regulates
                                                                         androgen-
                                                                         dependent
                                                                          gene
                                                                         expressio
                                                                         n by
                                                                         binding to
                                                                         androgen-
                                                                         responsiv
                                                                         e
                                                                         elements
                                                                         (ARE) [4]
                                                                         its DNA-
                                                                         binding
                                                                         domain
                                                                         can
                                                                         interact
                                                                         with
                   androgen                       http://local           leucine
                   receptor,                      host/cgi-              zipper of
                   AR,                            bin/biobas can form AP1 to
                   NR3C4,     rat,                e/transfac/ multimeric result in
                   dihydrotes Rattus              7.4/bin/get            mutual
                   tosterone norvegicu vertebrate TFProf.cgi complexe transrepre
T00042   AR        receptor. s         s          ?T00042 s [3]          ssion [2]. NULL


                                                                1H NMR:
                                                                2 zinc
                                                                ions
                                                                coordinate
                                                                d by 4        mediates
                                                 http://local   Cys           gene
                                                 host/cgi-      within        regulation
                  ER,                            bin/biobas     each zinc     in
                  estrogen rat,                  e/transfac/    finger 2      response
                  receptor, Rattus               7.4/bin/get    perpendic     to
                  NR3A1,    norvegicu vertebrate TFProf.cgi     ular alpha-   estrogen
T00258   ER-alpha ERalpha. s          s          ?T00258        helices       hormone NULL
                                                                           activates
                                                                           transcripti
                                                                           on in
                                                                           response
                                                                           to
                                                                           estrogen
                                                                           hormones
                                                                            (e.g.
                                                                           estradiol)
                                                                 1H NMR,   [6] [2]
                                                                 crystal   affinity for
                                                                 structure:estradiol
                                                                 2 zinc    (Kd 0,2
                                                                 ions      nM)
                                                                 coordinatehigher
                                                                 d by 4    than that
                                                                 Cys       of
                                                                 within    paralog
                                                                 each zinc ER-beta
                                                                 finger 2  <T04649>
                                                                 perpendic  (Kd 0,5
                                                                           nM) [2]
                                                                 ular alpha-
                                                                 helices   interaction
                                                                 [9] [3] C- with
                                                                 terminal  transcripti
                                                                           onal
                                                                 transcripti
                                                  http://local   on        coactivato
                                                  host/cgi-      activatingr SRC-1
                                                  bin/biobas     function  <T04632>
                  ER,                             e/transfac/    (TAF-2):
                  estrogen    mouse,              7.4/bin/get    hormone- increases
                  receptor,   Mus      vertebrate TFProf.cgi     inducible transcripti
T00259   ER-alpha NR3A1.      musculus s          ?T00259        [6]         onal      NULL
                                                                  1             inducible
                                                                  estrogen-     NLS also
                                                                  inducible     inducible
                                                                  NLS           by
                                                                  (nuclear      hydroxy-
                                                                  localizatio   tamoxifen,
                                                                  n signal)      not by
                                                                  within        ICI
                                                                  region E      164,384
                                                                  [11] AF-1     [11]
                                                                  (activating   discrimina
                                                                   function,    tion over
                                                                  previously    GRE-
                                                                                binding
                                                                  designate     through
                                                                  d TAF-1):     first zinc
                                                                  constitutiv   finger: E-
                                                                  e,            203, G-
                                                                  independe     204, A-
                                                                  ntly active   206 TAF-
                                                                  [19] [7] in   1 is
                                                                  yeast, 3      constitutiv
                                                                  independe     e, but cell-
                                                                  nt            specific
                                                                  subdomai      (active in
                                                                  ns are        CEF,
                                                   http://local   active (1-    poorly
                                                   host/cgi-      62, 80-       active in
                                                   bin/biobas     113, 118-     HeLa)
                  ER,                              e/transfac/    149) [7]      [21]
                  estrogen    human,               7.4/bin/get    activating    estrogen-
                  receptor,   Homo      vertebrate TFProf.cgi     subdomai      dependent
T00261   ER-alpha NR3A1.      sapiens   s          ?T00261        ns of AF-      binding     NULL


                                                                  can bind
                                                                  DNA as a
                                                                  homodime                 (adult:)
                                                                  r or as a                expressed
                                                   http://local   heterodim                 in
                   estrogen                        host/cgi-      er                       thymus,
                   receptor                        bin/biobas     <T05702>                 testis,
                   beta,                           e/transfac/     with ER-                ovary [3];
                   NR3A2,     human,               7.4/bin/get    alpha     agonist:       weak
                   ESTRB,     Homo      vertebrate TFProf.cgi     <T00261> estradiol       levels in
T04651   ER-beta   ESR2.      sapiens   s          ?T04651         [4].     [3]            spleen [3]
                                                                             activates
                                                                             transcripti
                                                                             on in
                                                                             response
                                                                             to ligand
                                                                             binding
                                                                             (estradiol)
                                                                              [1]
                                                                             affinity for
                                                                             estradiol
                                                                             (Kd 0,5
                                                                             nM) lower
                                                                             than that
                                                                             of
                                                                             paralog
                                                                             ER-alpha
                                                                             <T00259>
                                                                              [1]
                                                                activated    interaction
                                                                by Ras-       with
                                                                Raf-1-       transcripti
                                                                MAPK         onal
                                                                kinase       coactivato
                                                                and          r SRC-1
                                                                MAPK         <T04632>
                                                                pathway:
                                                 http://local   therefore    increases
                                                 host/cgi-      phosphory    transcripti
                                                 bin/biobas     lation at    onal
                  NR3A2,                         e/transfac/    pos. 60      activity
                  estrogen   mouse,              7.4/bin/get    (Serin) is   (binding
                  receptor   Mus      vertebrate TFProf.cgi     important    site        (adult):
T04649   ER-beta1 beta 1.    musculus s          ?T04649        [1]          <R01906> ovary [1]
                                                                                binds to
                                                                                serum
                                                                                response
                                                                                element
                                                                                (SRE)          embryo:
                                                                                increases      day 18:
                                                                                with           brain,
                                                                                myoblast       heart,
                                                                                differentiat   gizzard,
                                                                                ion            skeletal
                                                                                required       muscle
                                                                                for alpha-     [1];
                                                                                actin          additional
                                                                                transcripti    in day 10
                                                                                on [1]         in aorta
                                                                                stage 4        and in
                                                                                embryo:        day 14 in
                                                                                epiblast,      4th aortic
                                                                                blood          arch and
                                                                                islands        abdominal
                                                                                [1] stage       aorta [2];
                                                                                6              upregulate
                                                                                embryos:       d in
                                                                                neural         multinucle
                                                                                groove,        ated
                                                                                neural         (BudR for
                                                       http://local             plate,         60 hrs)
                                                       host/cgi-                primitive      and
                                                       bin/biobas               streak,        differentiat
                                                       e/transfac/              lateral        ed
                               chick,                  7.4/bin/get              plate          myotubes
                               Gallus       vertebrate TFProf.cgi     phosphory mesoder        (84 hrs
T00761   SRF      SRF.         gallus       s          ?T00761        lation.   m,             BudR) [1]


                                                       http://local
                                                       host/cgi-
                                                       bin/biobas           binds to
                                                       e/transfac/          serum
                                                       7.4/bin/get          response
                               cat, Felis   vertebrate TFProf.cgi phosphory element
T00762   SRF      SRF.         catus        s          ?T00762 lation       (SRE)    NULL


                   C/EBPdelt                        http://local      same
                   a, CELF,                         host/cgi-         DNA-                     ubiquitous
                   CRP3,                            bin/biobas        binding                  ;
                   NF-         rat,                 e/transfac/       specificity              abundant
                   IL6beta,    Rattus               7.4/bin/get       as                       in testis
         C/EBPdelt LF-         norvegicu vertebrate TFProf.cgi        C/EBPbet                 and
T00109   a         H3beta.     s         s          ?T00109           a / NF-IL6               adrenal [2]
                                                                         stronger
                                                                         transcripti
                                                                         onal
                                                                         activator
                                                                         than
                                                                         C/BEPbet
                                                                         a both
                                                                         can act
                                                                         synergistic
                                                                         ally [3]
                                                                         undetecta
                                                                         ble levels
                                                                         in normal
                                                                         cells, but
                                                                         induced
                                                                         by LPS or
                                                                         inflammat
                                                                         ory
                                                                         cytokines
                                                                         [3]
                                                                         induction
                                                                         of
                                                                         C/EBPdelt
                                                                         a (in
                                                                         contrast
                                                 http://local same       to
                                                 host/cgi- DNA-          C/EBPbet
                                                 bin/biobas binding      a) by IL-6
                   C/EBPdelt                     e/transfac/ specificity is at the
                   a, CRP3, human,               7.4/bin/get as          transcripti
         C/EBPdelt NF-       Homo     vertebrate TFProf.cgi C/EBPbet onal level ubiquitous
T00583   a         IL6beta. sapiens   s          ?T00583 a / NF-IL6 [1]              [3]
                                                                             strong
                                                                             transcripti
                                                                             on
                                                                             activator,
                                                                             synergistic
                                                                             ally acting
                                                                             with NF-
                                                                             kappaB,
                                                                             presumabl
                                                                             y by
                                                                             physical
                                                                             interaction
                                                                              [3]
                                                                             expressed
                                                                              very
                                                                             early
                                                                             during
                                                                             adipocyte
                                                                             differentiat
                                                                             ion, can
                                                                             be
                                                                             induced
                                                                             by
                                                                             adipogeni
                                                                             c
                                                                             hormones
                                                http://local   same
                                                host/cgi-      DNA-          expressio
                   C/EBPdelt                    bin/biobas     binding       n
                   a, CELF,                     e/transfac/    specificity   declines
                   CRP3,     mouse,             7.4/bin/get    as            before
         C/EBPdelt NF-       Mus     vertebrate TFProf.cgi     C/EBPbet      onset of  ubiquitous
T01114   a         IL6beta. musculus s          ?T01114        a / NF-IL6    C/EBPalp [4]
                Osf2,
                PEBP2alp
                haA,                                                        related to
                AML3,                                                       human
                PEBP2alp                                                    cleidocran
                haA1,                                                       ial
                Polyomavi                                                   dysplasia
                rus                                                         (CCD) [2]
                enhancer                                                    mapped
                binding                                                     to
                protein 2                                                   chromoso
                alpha A                                                     me
                subunit,                                                    region
                CBF-                                                        6p21 [2]
                alpha 1,                                       factor       essential
                RUNX2,                                         was          for
                Runt-                                          found to     skeletal
                related                                        be           morphoge
                transcripti                                    associate    nesis [2]
                on factor                                      d with the   controls
                2, Core-                                       nuclear      the
                binding                                        matrix [3]   pathway
                factor,                         http://local   2 splice     of
                alpha 1                         host/cgi-      variants     differentiat
                subunit,                        bin/biobas     AML3a        ion into
                Acute                           e/transfac/    <T03983>     the
                myeloid     human,              7.4/bin/get     and         osteoblast
                leukemia Homo        vertebrate TFProf.cgi     AML3b         lineage
T02281   AML3   3 protein. sapiens   s          ?T02281        <T03984>     [1]          NULL
                                                                          major
                                                                          componen
                                                                          t of the
                 Osf2,                                                    osteoblast
                 PEBP2aA,                                                 -specific
                                                                          complex
                 PEBP2A1,                                                 of
                  CBF-                                                    primary
                 alpha 1,                                                 osteoblast
                 RUNX2,                                                   s [1]
                 Runt-                                                    translation
                 related                                                  al arrest
                 transcripti                                              of AML
                 on factor                                                proteins
                 2, Core-                                                 cause
                 binding                                                  decrease
                 factor,                                                  in alkaline
                 alpha 1                                                  phosphata
                 subunit,                                                 se levels,
                 Acute                                                    osteocalci
                 myeloid                                         immunore n levels,
                 leukemia                           http://local active   and a
                 3 protein,                         host/cgi- species     reduced
                 Osteoblas                          bin/biobas of 45, 60 number         calvaria,
                 t-specific    rat,                 e/transfac/ and 65    of            metaphysi
                 transcripti   Rattus               7.4/bin/get kDa in    mineralize    s,
                 on factor     norvegicu vertebrate TFProf.cgi Western d nodules        epiphysis
T02441   AML3    2.            s         s          ?T02441 assay [1] [1]               [1]


                                                                           related to
                                                                           human
                                                                           cleidocran
                                                                           ial
                                                                           dysplasia
                                                                           (CCD) [1]
                                                                           mapped
                                                                           to
                                                                           chromoso
                                                                 factor    me
                 PEBP2alp                           http://local was       region
                 ha1,                               host/cgi- found to 6p21 [1]
                 Osf2,                              bin/biobas be          essential
                 PEBP2alp                           e/transfac/ associate for
                 haA, CBF- human,                   7.4/bin/get d with the skeletal
                 alpha 1,  Homo          vertebrate TFProf.cgi nuclear     morphoge
T03983   AML3a   RUNX2. sapiens          s          ?T03983 matrix [2] nesis [1] NULL
                                                                             does
                                                                             probably
                                                                             not
                                                                             heterodim
                                                                             erize with
                                                                             PEBP2bet
                                                                             a (Cbf
                                                                             beta) [1]
                                                                             expressio
                                                                             n occurs
                                                                             early
                                                                             during
                                                                             skeletal
                                                                             developm
                                                                             ent and is
                                                                             restricted
                                                                             to cells of
                                                                             the
                                                                             mesenchy
                                                                             mal
                                                                             condensat
                                                              splice         ions and
                                                              variants       the
                                                              are            osteblast
                                                              <T01062>       lineage
                                                               and           [4]
                                               http://local   <T01063>       PEBP2alp
                                               host/cgi-       second        haA (-/-)
                                               bin/biobas     Met is the     mice
                  Osf2,                        e/transfac/    better         scarcely
                  CBFA1,   mouse,              7.4/bin/get    translation    breathed, bone and
         PEBP2alp PEBP2alp Mus      vertebrate TFProf.cgi     al initiator   showed      osteoblast
T02266   haA      haA.     musculus s          ?T02266        in vitro [1]   uniformly s [4]
                 AML1,
                 PEBP2alp
                 haB,
                 Acute
                 myeloid
                 leukemia
                 1 protein,
                 Core-
                 binding
                 factor,
                 alpha 2                                                      related to
                 subunit,                                                     t(8,21)
                 RUNX1,                                                       acute
                 CBF-                                                         myeloid
                 alpha 2,                                        splice       leukemia
                 Runt-                                           variants     cross-
                 related                                         are          regulation
                 transcripti                                     AML1a        between
                 on factor                                       <T02256>     isoforms
                 1,                                              , AML1b      and
                 Polyomavi                        http://local   <T02245>     familiy
                 rus                              host/cgi-      , AML1c      members
                 enhancer                         bin/biobas     <T02246>     at the
                 binding                          e/transfac/    ,            transcripti
                 protein 2 human,                 7.4/bin/get    AML1Delt     onal level
                 alpha B     Homo      vertebrate TFProf.cgi     aN           possible
T01067   AML1    subunit.    sapiens   s          ?T01067        <T02220>     [1]         NULL


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                            gibbon               e/transfac/
                            ape,                 7.4/bin/get
                            Hylobates vertebrate TFProf.cgi
T02457   AML1    CBF.       lar       s          ?T02457                                NULL


                                                 http://local    7 + 3 zinc
                 Evi-1,                          host/cgi-       finger
                 ecotropic                       bin/biobas      motifs       involved
                 virus                           e/transfac/     acidic       in
                 integration mouse,              7.4/bin/get     region       myeloid
                  1 site     Mus      vertebrate TFProf.cgi      phosphory    transform
T00273   Evi-1   protein.    musculus s          ?T00273         lation       ation     NULL
                   BPc,
                   CBP,
                   C/EBP,                                                                liver;
                   C/EBPalp                                                              lower
                   ha,                             http://local                          levels in
                   EBP20,                          host/cgi-                             spleen,
                   CCAAT/e                         bin/biobas                            kidney,
                   nhancer    clawed               e/transfac/                           ovary,
                   binding    frog,                7.4/bin/get                           oviduct;
                   protein    Xenopus   vertebrate TFProf.cgi                            very low:
T01388   C/EBP     alpha.     laevis    s          ?T01388 length:          critically   brain [1]
                                                                359 AA      involved
                                                                [13] or     in energy
                                                                395 AA      homeosta
                                                                (ORF in     sis and
                                                                EMBL        may have
                                                                #M62362)    a role in
                                                                            regulating
                                                              alternative   the
                                                                            balance
                                                              translation   between
                                                               initiation   cell
                                                              product is    growth
                                                              C/EBPalp      and
                                                              ha (p30       differentiat
                                                              variant)      ion [21]
                  BPc,                                        <T02026>      [12] [2]
                  CBP,                                                      knock-out
                  C/EBP,                                      C/EBPalp      mice are
                  C/EBPalp                                    ha            unable to
                  ha,                                         exhibits a    store
                  EBP20,                                      very          hepatic
                  p42(C/EB                                    relaxed       glycogen
                  Palpha),                                    DNA-          and die
                  p42C/EBP                                    binding       from
                  alpha,                                      specificity   hypoglyce
                  C/EBPalp                     http://local   [23] the N-   mia [2]
                  ha(p42),                     host/cgi-      terminal      Myc/Max
                  CCAAT/e                      bin/biobas     part of       heterodim
                  nhancer                      e/transfac/    the           ers bind
                  binding  mouse,              7.4/bin/get    molecule      to and
         C/EBPalp protein  Mus      vertebrate TFProf.cgi     exhibits      represses
T00104   ha       alpha.   musculus s          ?T00104        antimitotic   the          (liver)
                                                                             inhibits
                                                                             cell
                                                                             proliferatio
                                                                             n by
                                                                             enhancing
                                                                              the level
                                                                             of p21
                                                                             (WAF-1)
                  BPc,                                                       [1] this is
                  CBP,                                                       due to
                  C/EBP,                                                     enhanced
                  C/EBPalp                                                   gene
                  ha,                           http://local                 expressio
                  EBP20,                        host/cgi-                    n and
                  CCAAT/e                       bin/biobas                   posttransl
                  nhancer                       e/transfac/                  ational
                  binding  human,               7.4/bin/get                  stabilizatio
         C/EBPalp protein  Homo      vertebrate TFProf.cgi                   n of p21
T00105   ha       alpha.   sapiens   s          ?T00105                      [1]          NULL


                                                               use of
                                                               internal
                                                               translation
                                                                initiation
                                                               codons
                                                               may be
                                                               due to
                                                               leaky
                                                               ribosome
                  BPc,                                         scanning,
                  CBP,                                         giving
                  C/EBP,                                       rise to
                  C/EBPalp                                     products
                  ha,                           http://local   of 40 kDa
                  EBP20,                        host/cgi-      (Met-15),
                  CCAAT/e                       bin/biobas     29 kDa
                  nhancer                       e/transfac/    (Met-102)
                  binding  chick,               7.4/bin/get    and 14
         C/EBPalp protein  Gallus    vertebrate TFProf.cgi     kDa (Met-
T00107   ha       alpha.   gallus    s          ?T00107        231) [1]                 NULL
                                                                 scissors-     activator
                                                                 grip and      [36] [37]
                                                                 helical-      [18]
                                                                 fork          required
                                                                 models        for and
                                                                 for DNA-      regulating
                                                                 binding       the
                                                                 scissors      terminal
                                                                 grip: upon    adipocyte
                                                                 DNA-          differentiat
                                                                 binding,      ion [36]
                                                                 the alpha-    [26] [4],
                                                                 helices of    thereby
                                                                 the two       reciprocall
                                                                 leucine       y
                                                                 zippers       regulated
                                                                 extend        as and         nonprolife
                                                                 towards       prevented      rating
                                                                 the basic     by c-myc       liver,
                                                                 regions       [15]           adipose,
                  BPc,                                           which         expressed      small
                  CBP,                                           make the       only in       intestine,a
                  C/EBP,                                         DNA-          fully          drenal
                  C/EBPalp                                       contacts      differentiat   gland,
                  ha,                                            [43] as a     ed cells       placenta,
                  EBP20,                                         result,       [39]           lung,
                  LF-                             http://local   dissociatio   decreased      brain,
                  H3beta,                         host/cgi-      n              levels in     skin [39];
                  CCAAT/e                         bin/biobas     constant      regenerati     low levels
                  nhancer    rat,                 e/transfac/    for           ng liver       in muscle
                  binding    Rattus               7.4/bin/get    homodime      [17]           and
         C/EBPalp protein    norvegicu vertebrate TFProf.cgi     rization      repressor      thymus
T00108   ha       alpha.     s         s          ?T00108        increases     at the         [28]


                                                http://local                   inhibits
                                                host/cgi-                      DNA-
                 CHOP-                          bin/biobas                     binding of
                 10,                            e/transfac/                    C/EBPalp
                 GADD       mouse,              7.4/bin/get                    ha or
                 153        Mus      vertebrate TFProf.cgi                     C/EBPbet liver
T00127   CHOP-10 (hamster). musculus s          ?T00127                        a [1]      enriched
                                                                     induced
                                                                     during
                                                                     growth
                                                                     arrest [2]
                                                                     and
                                                                     (mainly)
                                              http://local           by signals
                         chinese              host/cgi-              from
                         hamster,             bin/biobas             stressed
                CHOP-10 Cricetulus            e/transfac/            endoplas
                (mouse),                      7.4/bin/get            mic
         GADD   GADD     longicaud vertebrate TFProf.cgi             reticulum liver
T00299   153    153.     atus      s          ?T00299                [1]        enriched


                                                                       inducible
                                                                       by
                                                                       calcium
                                                                       ions [2]
                                                                       causes
                                                                       cell
                                                                       growth
                                                                       arrest
                                                                       at/around
                                                                       the G1/S
                                                                       checkpoin
                                                                       t [1] an
                                                                       oncogenic
                                                                        variant,
                                                                       TLS-
                                                                       CHOP, is
                                                                       associate
                                                                       d with
                                                                       adipose
                GADD                                         the       tissue
                153,                                         oncogenic myxoid
                CHOP,                           http://local variant   liposarco
                growth                          host/cgi- TLS-         ma it is
                arrest                          bin/biobas CHOP        not
                and DNA-                        e/transfac/ has a      capable
                damage- human,                  7.4/bin/get large N-   to induce
         GADD   inducible Homo       vertebrate TFProf.cgi terminal    growth    adipocyte
T01387   153    gene 153. sapiens    s          ?T01387 extension arrest [1] s [1]
                                                                                  may play
                                                                                  a
                                                                                  regulatory   definitive
                                                                                  role in      adult
                                                                                  developin    erythrocyt
                                                     http://local                 g chicken    es, T
                                                     host/cgi-                    brain and    lymphocyt
                                                     bin/biobas     2 zinc        T-cell       es,
                                                     e/transfac/    finger        specific     embryonic
                                chick,               7.4/bin/get    motifs pI     gene          brain,
                  GATA-3,       Gallus    vertebrate TFProf.cgi     (calc.) =     expressio    adult
T00314   GATA-3   NF-E1c.       gallus    s          ?T00314        9.9           n            kidney [7]
                  peroxisom
                  e
                  proliferato
                  r-                                 http://local
                  activated                          host/cgi-
                  receptor                           bin/biobas                   control of
                  gamma,        clawed               e/transfac/                  peroxisom    fat body,
                  PPARgam       frog,                7.4/bin/get                  al beta-     kidney;
         PPAR-    ma,           Xenopus   vertebrate TFProf.cgi                   oxidation    (weaker:
T01354   gamma    NR1C3.        laevis    s          ?T01354                      pathway      liver)


                                                                                  activator
                                                                                  as a
                                                                    one of        heterodim
                                                                    two           er with
                                                                    known         RXR-
                                                                    isoforms      alpha
                                                                    produced      member
                                                                    form          of the
                                                                    alternative   steroid
                                                                                  hormone
                                                                    promoters     receptor
                                                                      and by      superfamil
                                                                    alternative   y
                                                                      splicing    expressio
                                                                    [3], see      n is under
                  peroxisom                                         mouse         control of
                  e                                                 PPAR-         C/EBPbet
                  proliferato                                       gamma         a,
                  r-                              http://local      <T05347>      probably
                  activated                       host/cgi-          and          synergizin
                  receptor                        bin/biobas        mouse         g with
                  gamma,                          e/transfac/       PPAR-         C/EBPdelt
                  PPARgam mouse,                  7.4/bin/get       gamma2        a, and of
         PPAR-    ma,         Mus      vertebrate TFProf.cgi        <T05332>      glucocorti
T02529   gamma1   NR1C3.      musculus s          ?T02529           .             coids [2] NULL
                                                                  One of       activator
                                                                  four         as a
                                                                  known        heterodim
                                                                  variants     er with
                                                                  of           RXR-
                                                                  <T05351>     alpha
                                                                               predomin
                                                                  PPARgam      ant
                                                                  ma2 is a     isoform of
                                                                  isoform      PPAR-
                                                                  with 28      gamma in
                                                                  additional   man [7]
                                                                  N-           ligands:      adipocyte
                                                                  terminal     fibrates,     s, bone
                                                                  aminoacid    fatty         marrow,
                                                                  s in         acids,        skeletal
                                                                  compariso    prostanoid    muscle,
                  peroxisom                                       n with       s,            spleen,
                  e                                               gamma1       thiazolidin   testis,
                  proliferato                                     [8]          ediones       brain and
                  r-                                              PPARgam      (anti-        liver [8];
                  activated                                       ma binds     diabetic      adipocyte
                  receptor,                                       to DNA       drugs) [9]    s, large
                  peroxisom                                       as a         one of        intestine
                  e                                               heterodim    the key       (high
                  proliferato                                     er with      regulators    level),
                  r-                               http://local   the           of           kidney,
                  activated                        host/cgi-      retinoid X   adipogene     liver,
                  receptor                         bin/biobas     receptor     sis           small
                  gamma,                           e/transfac/    (RXR)        mRNA for      intestine
                  PPARgam human,                   7.4/bin/get    <T01345>     gamma1        (intermedi
         PPAR-    ma,         Homo      vertebrate TFProf.cgi     ,            is slow       ate level)
T02736   gamma1   NR1C3.      sapiens   s          ?T02736        <T01334>     and           [7]
                                                                                             (adult:)
                                                                                             weak
                                                                                             levels in
                                                                                             adipose
                                                                                             tissue,
                                                                                             spleen,
                                                                                             lung,
                  peroxisom                                                                  ovary,
                  e                                                                          mammary
                  proliferato                                     isoform                     gland,
                  r-                                              <T04780>                   small
                  activated                        http://local    contains                  intestine
                  receptor                         host/cgi-      30                         [1]; very
                  gamma,                           bin/biobas     additional                 weak
                  PPARgam                          e/transfac/    N-                         levels in
                  ma,         cattle,              7.4/bin/get    terminal                   kidney,
         PPAR-    NR1C3,      Bos       vertebrate TFProf.cgi     amino                      muscle,
T04794   gamma1   PPARG. taurus         s          ?T04794        acids                      heart [1]
                                                                  One of       activator
                                                                  four         as a
                                                                  known        heterodim
                                                                  variants     er with
                                                                  of           RXR-
                                                                  <T05351>     alpha [6]
                                                                               PPARgam
                                                                  PPARgam      ma2 is
                                                                  ma2          minor
                                                                  binds to     isoform in
                                                                  PPREs        man [6]
                                                                  (PPARga      ligands:
                                                                  mma          fibrates,
                                                                  response     fatty
                                                                  elements)    acids,
                                                                  as a         prostanoid
                  peroxisom                                       heterodim    s,
                  e                                               er with      thiazolidin
                  proliferato                                     retinoid X   ediones
                  r-                                              receptor     (anti-        adipocyte
                  activated                                       (RXR)        diabetic      s, bone
                  receptor                                        <T01345>     drugs) [9]    marrow,
                  gamma,                                          ,            overexpre     skeletal
                  PPARgam                                         <T01334>     sssion of     muscle,
                  ma,                                              [5]         PPARgam       spleen,
                  NR1C3,                                          PPARgam      ma2 in        testis,
                  peroxisom                        http://local   ma2 and      fibroblast    brain and
                  e-                               host/cgi-      RXR          cell lines    liver [8];
                  proliferato                      bin/biobas     <T01345>     converts      heart,
                  r-                               e/transfac/    ,            them to       pancreas
                  activated human,                 7.4/bin/get    <T01334>     adipocyte     [5];
         PPAR-    receptor Homo         vertebrate TFProf.cgi                  s [10]        adipocyte
T03731   gamma2   gamma 2. sapiens      s          ?T03731 cooperativ          PPARgam       s [6]

                                                                                             (adult:)
                                                                                             high
                                                                                             levels in
                                                                                             adipose
                                                                                             tissue,
                                                                                             spleen,
                                                                                             lung [1];
                                                                                             lower
                  peroxisom                                                                  levels in
                  e                                                                          ovary,
                  proliferato                                                                mammary
                  r-                                                                          gland,
                  activated                        http://local                              small
                  receptor                         host/cgi-                                 intestine
                  gamma,                           bin/biobas                                [1]; very
                  PPARgam                          e/transfac/                               low levels
                  ma,         cattle,              7.4/bin/get                               in kidney,
         PPAR-    NR1C3,      Bos       vertebrate TFProf.cgi                                muscle,
T04780   gamma2   PPARG. taurus         s          ?T04780                                   heart [1]
                                                http://local
                                                host/cgi-
                                                bin/biobas
                (Jun)2,                         e/transfac/
                AP1,       clawed               7.4/bin/get
                Fos/Jun,   frog,     vertebrate TFProf.cgi
T00027   AP-1   PEA1.      Xenopus   s          ?T00027                              (oocytes)
                                                               composed
                                                                of two
                                                               subunits:
                                                               two Jun-     down-
                                                               peptides     modulated
                                                               or one        by
                                                               Jun-         glucocorti
                                                http://local   <T00133>     coids
                                                host/cgi-       and one     through
                (Jun)2,                         bin/biobas     Fos-         direct
                AP1,                            e/transfac/    peptide      interaction
                Fos/Jun,   human,               7.4/bin/get    <T00123>      with GR
                PEA1       Homo      vertebrate TFProf.cgi      (or         induced
T00029   AP-1   (mouse).   sapiens   s          ?T00029        relatives)   by TPA [1] NULL


                                                http://local
                                                host/cgi-
                (Jun)2,                         bin/biobas
                AP1,       monkey,              e/transfac/
                Fos/Jun,   Cercopith            7.4/bin/get
                PEA1       ecus      vertebrate TFProf.cgi Phosphor
T00030   AP-1   (mouse).   aethiops s           ?T00030 ylation                      (COS-7)
                                                             composed
                                                              of two
                                                             subunits:
                                                             two Jun-
                                                             peptides
                                                             or one
                                                             Jun-
                                                http://local <T00132>
                                                host/cgi-     and one
                (Jun)2,                         bin/biobas Fos-
                AP1,       rat,                 e/transfac/ peptide
                Fos/Jun,   Rattus               7.4/bin/get <T00124>
                PEA1       norvegicu vertebrate TFProf.cgi (or
T00031   AP-1   (mouse).   s         s          ?T00031 relatives)                   NULL
                                                                      AP-1
                                                                      level
                                                            composed decreases
                                                             of two    in murine
                                                            subunits: mammary
                                                            two Jun-   epithelial
                                                            peptides cells
                                                            or one    upon
                                                            Jun-      differentiat
                                               http://local <T00131> ion
                (Jun)2,                        host/cgi-     and one induced
                AP1,                           bin/biobas Fos-        by
                Fos/Jun,                       e/transfac/ peptide    dexameth
                PEA1,      mouse,              7.4/bin/get <T00122> asone or
                PEA1       Mus      vertebrate TFProf.cgi (or         prolactin
T00032   AP-1   (mouse).   musculus s          ?T00032 relatives) [2]              NULL


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                                                 e/transfac/
                                                 7.4/bin/get
                                      vertebrate TFProf.cgi
T01115   AP-1   AP1.       hamster    s          ?T01115                         NULL


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                                                 e/transfac/
                           chick,                7.4/bin/get
                AP1,       Gallus     vertebrate TFProf.cgi
T01140   AP-1   PEA1.      gallus     s          ?T01140                         NULL


                                                http://local
                                                host/cgi-             mediates
                                                bin/biobas            phorbol
                           gibbon               e/transfac/           ester
                           ape,                 7.4/bin/get           responses
                           Hylobates vertebrate TFProf.cgi             through
T01156   AP-1   AP1.       lar       s          ?T01156               TRE       NULL
                                              http://local
                                              host/cgi-
                          fruit fly,          bin/biobas
                          Drosophil           e/transfac/
                          a                   7.4/bin/get
                          melanoga vertebrate TFProf.cgi
T01132   AP-1   AP1.      ster       s        ?T01132          involved NULL
                                                               in
                                                               response
                                                               to
                                                               oxidative
                                                               stress/oxy
                                                               gen
                                                               detoxificat
                                                               ion and
                                                               metal
                                                               resistance
                                                                [6]
                                                               similar to,
                                                               but
                                                               different
                                                               from
                                                               GCN4 an
                                                               upstream
                                                               ORF
                                                               allows
                                                               40S
                                                               subunits
                                                               to
                                                               proceed
                                                               via leaky
                                                               scanning
                AP1,                            http://local   and re-
                yAP1,                           host/cgi-      initiation
                PAR1,                           bin/biobas     to the
                PDR4,     yeast,                e/transfac/    major
                SNQ3,     Saccharo              7.4/bin/get    ORF [4]
                YML007W   myces      vertebrate TFProf.cgi     thioredoxi
T00028   YAP1   .         cerevisiae s          ?T00028        n system NULL
                                                                TALE          acts as a
                                                                (three        repressor
                                                                amino         of RXR-
                                                                acid loop     alpha
                                                                extension)    <T01345>
                                                                 homeo
                                                                domain        dependent
                                                                superclas
                                                                s [6] [8]     transcripti
                                                                SMAD-2        onal          (adult:)
                                                                <T04095>      activation    highly
                                                                              by mutual     expressed
                                                                dependent     exclusive      in
                                                                              binding       placenta,
                                                                interaction   [8] CPR       prostate,
                                                                 with Fast-   (cell cycle   testis,
                                                                2             progressio    ovary,
                                                                <T04100>      n             small
                                                                 [5]          restoratio    intestine
                                                                competes      n) gene,      and
                                                                with p300     overexpre     colon,
                                                                <T01427>      ssion can     weakly
                                                                 for          overcome      expressed
                                                                binding to    G1 arrest      in lung,
                                                                the           signals in    liver,
                                                                SMAD-2        the yeast     kidney,
                                                 http://local   <T04095>      cell cycle    pankres,
                5 TG3                            host/cgi-       complex      [7]           spleen,
                interacting                      bin/biobas     [5]           interacts     thymus,
                 factor,                         e/transfac/    competitiv    with          blood
                TG-         human,               7.4/bin/get    e binding     SMAD-2        leukocytes
                interacting Homo      vertebrate TFProf.cgi     with Meis-    <T04095>      , spinal
T04076   TGIF    factor.    sapiens   s          ?T04076        2              and          cord [8]
                                                                                            (embryo
                                                                                            12 days:)
                                                                                            1.
                                                                                            branchial
                                                                 TALE                       arch, lung
                                                                 (three                     bud,
                                                                 amino                      duodenu
                                                                 acid loop                  m,
                                                                 extension)                 hindlimb
                                                                  homeo                     buds,
                                                                 domain                     brain,
                                                                 superclas                  (embryo
                                                                 s [1] [2]     probably 15 days:)
                                                                 89%           regulates hippocam
                                                                 amino         target       pal
                                                                 acid          genes        formation,
                                                                 identity to   involved
                                                                 human         in the       mesencep
                                                                 TGIF          proliferatio h. vesicle,
                                                                 <T04076>      n,           cerebellar
                                                                  [2]          migation plate,
                                                                 specificall   and/or       vertebra,
                                                                 y             differentiat kidney,
                                                                 expressed     ion of       intestine,
                                                  http://local    in the       particular thymus,
                  5 TG3                           host/cgi-      developin     neuronal upper
                  interacting                     bin/biobas     g             cell         molars,
                   factor,                        e/transfac/    cerebellu     lineages tongue,
                  TG-         mouse,              7.4/bin/get    m and         in the       (adult:)
                  interacting Mus      vertebrate TFProf.cgi     hippocam      developin prolif.
T04077   TGIF      factor.    musculus s          ?T04077        pus [2]       g brain [2] cells [2]
                                                                               involved
                                                                               in
                                                http://local                   regulation
                                                host/cgi-                      of liver
                                                bin/biobas                     and          liver
                           rat,                 e/transfac/                    intestinal (intestine,
                  HNF3B,   Rattus               7.4/bin/get                    gene         lung,
                  HNF3beta norvegicu vertebrate TFProf.cgi                     expressio stomach,
T01049   HNF-3B   .        s         s          ?T01049                        n [2]        ovary)
                                                                      gene
                                                                      locus is
                                                                      very
                                                                      close to
                                                                      locus of
                                                                      Fkh-6
                                                                      <T02417>
                                                                       [5] K.O.
                                                                      mice die
                                                                      in most        (embryoni
                                                                      cases          c)
                                                                      prenatally     mesoder
                                                                      (beginning     m
                                                                       13.5          (earlier),
                                                                      dpc)           mesenchy
                                                                      surviving      me and
                                                                      animals        derivative
                                                                      show           s (later,
                                                                      severe         mainly
                                                                      cranofacia     head
                                                                      l and          region)
                                                                      vertebral      [6], dorsal
                                                                      defects,       aortas
                                                                      which          [4];
                 Mesenchy                                             may be         (adult)
                 me fork                                              due to the     muscle,
                 head 1,                      http://local            marked         heart,
                 Fkh-14,                      host/cgi-               reduction      kidney,
                 Fork                         bin/biobas     gene is  in the         (weaker
                 head                         e/transfac/    located  proliferatio   in) brain,
                 homolog mouse,               7.4/bin/get    on       n and          fat, lung,
                 14, MFH- Mus      vertebrate TFProf.cgi     chromoso (probably)     liver,
T02445   FOXC2   1.       musculus s          ?T02445        me 8 [5]  the           gonads [5]
                                                              possibly
                                                              functions
                                                              as an
                                                              inhibitor
                                                              of
                                                              differentiat
                                                              ion in
                                                              early
                                                              stages of
                                                              thyroid
                                                              developm
                                                              ent,
                                                              perhaps
                                                              by
                                                              interfering
                                                               with
                                                              transcripti
                                                              onal
                                                              activation
                                                              of thyroid-
                                                              specific
                                                              gene
                                                              expressio
                                               http://local   n by TTF-
                                               host/cgi-      1
                                               bin/biobas     <T00856>
                          rat,                 e/transfac/     and Pax-
                          Rattus               7.4/bin/get    8            (thyroid
                          norvegicu vertebrate TFProf.cgi     <T01829> FRTL
T01133   FOXE1   TTF-2.   s         s          ?T01133         [1]         cells)
                                                                              (embryoni
                                                                              c)
                                                                              extraembr
                                                                              yonic and
                                                                              lateral
                                                                              mesoder
                                                                              m,
                                                                              splanchni
                                                                              c
                                                                              mesoder
                                                                              m [2];
                                                                              (adult)
                                                                              weak in
                                                                              prostate
                                                                              and
                                                                              placenta,
                                                                              moderate
                                                                              in colon
                                                                              and small
                 HNF-                                                         intestine
                 3/Fkh                                                        [2], type II
                 Homolog                        http://local                  pneumocy
                 8, Freac-                      host/cgi-                     tes [3]
                 1                              bin/biobas                    and
                 (Forkhead                      e/transfac/                   fibroblasts
                  RElated mouse,                7.4/bin/get                    [2] of
                 ACtivator- Mus      vertebrate TFProf.cgi                    alveolar
T02461   FOXF1   1), HFH-8. musculus s          ?T02461                       sac
                                                                              (fetal)
                                                                              lung,
                                                                              brain
                                                                              (weak);
                                                                sequence      (adult)
                                                                not           placenta,
                                                 http://local   complete,     lung,
                 Forkhead                        host/cgi-      translation   (weaker
                 RElated                         bin/biobas      start has    in)
                 ACtivator-                      e/transfac/    not yet       prostate,
                 2,         human,               7.4/bin/get    been          small
                 FKHL6,     Homo      vertebrate TFProf.cgi     determine     intestine,
T02465   FOXF2   FREAC2. sapiens      s          ?T02465        d [2]         colon
                                                                    is a
                                                                    transactiv
                                                                    ator for
                                                                    the lung
                                                                    surfactant
                                                                    protein B
                                                                    (SBP)
                                                                    promotor
                                                                    <G001045
                                                                    > the C-
                                                                    terminal         (adult)
                                                                    half of the      bronchiola
                                                                    protein          r
                                               http://local         contains         epithelial
                                               host/cgi-            two              cells and
                                               bin/biobas           transactiv       type II
                                               e/transfac/ gene is  ating            pneumocy
                           mouse,              7.4/bin/get composed domains          tes, small
                           Mus      vertebrate TFProf.cgi of 2      C and D          intestine
T02514   FOXF2   LUN.      musculus s          ?T02514 exons [1] [1]                 (weak)

                                                                            a
                                                                            complex
                                                                            is formed
                                                                            in
                                                                            response
                                                                            to TGF-
                                                              SMAD-2        beta
                                                              <T04095>      treatment
                                                                            which
                                                              dependent     binds to
                                                                            ARE
                                                              interaction   (Activin
                                                               with         Response
                                                              TGIF           Element)
                                                              <T04076>      and
                                                               to a Fast-   includes
                                                              SMAD-         at least
                                               http://local   TGIF          three
                 forkhead                      host/cgi-      complex       proteins,
                 activin                       bin/biobas     [3]           FAST-2,
                 signal                        e/transfac/    interaction   SMAD-2
                 transduce mouse,              7.4/bin/get     with         and
                 r 2, FAST- Mus     vertebrate TFProf.cgi     SMAD-3        SMAD-4
T04100   FOXH2   2, FAST2. musculus s          ?T04100        [2].          [2].      NULL
                                                                                     (embryoni
                                                                                     c)
                                                                                     visceral
                                                                                     endoderm
                                                                                      [3];
                                                                                     (adult)
                                                                                     brain
                                                                                     cortex
                                                  http://local                       (weak),
                                                  host/cgi-                          bronchiola
                                                  bin/biobas gene is                 r
                    HNF-                          e/transfac/ located                epithelium
                    3/Fkh     mouse,              7.4/bin/get on                      (clara
                    Homolog Mus        vertebrate TFProf.cgi chromoso activator cells) [5],
T02460   FOXJ1      4, HFH-4. musculus s          ?T02460 me 11 [5] [4]              testis [2]
                                                               binds to              (fetus:)
                                                               two                   liver [1],
                                                               different             (adult:)
                                                               types of              spleen,
                                                               sequence              thymus,
                                                               s, so                 prostate,
                                                               FOXJ2                 testis,
                                                               may bind              ovary,
                                                               DNA in                small
                                                               two                   intestine,
                                                               different             colon,
                                                               independe             leukocytes
                                                               nt                    , heart,
                                                               manners               brain,
                                                               [1] two               placenta,
                                                               splice                lung,
                                                               variants:             liver,
                                                               one long              skel.
                                                               and one               muscle,
                                                               short                 kidney,
                                                               <T04171>              pancreas,
                                                                isoform              (cell
                                                               which                 lines:)
                                                               differ in transcripti NIN3T3,
                                                               expressio onal        ES-2,
                                                  http://local n level   activator Chang,
                    FHX.L,                        host/cgi- and          [1] [2]     C33,
                    fork head                     bin/biobas transcripti may be      COS,
                    homologo                      e/transfac/ onal       involved HeLa,
         FOXJ2      us X,     human,              7.4/bin/get activation in early    Hep3B,
         (long      long      Homo     vertebrate TFProf.cgi potential developm H5, UT-7
T04169   isoform)   isoform. sapiens   s          ?T04169 [2]            ent [1]     [2]
                  ILF-1,                         http://local
                  interleukin                    host/cgi-
                                                 bin/biobas     fork head
                  enhancer                       e/transfac/    domain
                  binding   human,               7.4/bin/get    essential                    (cell
                  factor 1, Homo      vertebrate TFProf.cgi     for DNA-                     lines:)
T01088   FOXK1a   ILF.      sapiens   s          ?T01088        binding [2]                  HeLa [2]


                                                                alternative
                                                                 splice       does not
                                                                form of       acts as a
                                                                the HFH-      transcripti
                                                                11 gene       onal
                                                                that          activator,
                                                                contains      although
                                                                2             the
                                                                additional    alternative
                                                                exons [3]     ly spliced
                                                                the gene      protein
                                                                consists      <T02516>
                                                                of 10+         does (on
                                                                exons         an
                                                                (very         artificial
                                                                unusual       promoter)
                                                                for fork      the
                                                                head          additional
                  HNF-                           http://local   genes)        exon A2
                  3/Fkh                          host/cgi-      the gene      causes
                  Homolog                        bin/biobas     is located    the loss       studied
                  11A,                           e/transfac/    on            of             only in
                  FKHL16A, human,                7.4/bin/get    chromoso      transactiv     mouse so
                   HFH-    Homo       vertebrate TFProf.cgi     me            ating          far, see
T02517   FOXM1a   11A.     sapiens    s          ?T02517        12p13 [2]     activity [3]   <T02515>
                                                               spliceform
                                                                of the
                                                               HFH-11
                                                               gene, that
                                                               lacks 2
                                                               exons the
                                                               gene
                                                               consists
                                                               of 10+       acts as
                                                               exons        transcripti
                                                               (very        onal
                                                               unusual      activator
                                                               for fork     on an
                                                               head         artificial
                                                               genes)       promoter
                                                http://local   [3] the      the
                                                host/cgi-      gene is      alternativl
                                                bin/biobas     located      y spliced     studied
                                                e/transfac/    on           protein       only in
                           human,               7.4/bin/get    chromoso     <T02517>      mouse so
                           Homo      vertebrate TFProf.cgi     me            does not     far, see
T02516   FOXM1b   HFH-11B. sapiens   s          ?T02516        12p13 [2]    [3]           <T02515>

                                                                            binds to
                  HTLF,                         http://local                the
                  human T-                      host/cgi-                   human T-
                  cell                          bin/biobas                  cell
                  leukemia                      e/transfac/                 leukemia
                  virus    human,               7.4/bin/get                 virus long
                  enhancer Homo      vertebrate TFProf.cgi                  terminal
T04206   FOXN2    factor.  sapiens   s          ?T04206                     repeat [1] NULL
                                                              chromoso      activator,
                                                              mal           PAX3-
                                                              translocati   FKHR
                                                              on t(2        fusion
                                                              13)(q35       protein is
                                                              q14)          a more
                                                              causing       potent
                                                              alveolar      transcripti
                                                              rhabdomy      onal
                                                              osarcoma      activator
                                                              s fuses       than the
                                                              Pax-3(1-      normal
                                                              391) with     PAX3
                                                              FKHR [4]      although
                                                              [5] in        the
                                                              PAX3-         binding to
                                                              FKHR the      the e5
                                                              forkhead      recognitio
                                                              domain of     n
                                                              FKHR is       sequence
                                                              destroyed     is
                                                              while the     significantl
                                                              homeodo       y
                                                              main and      impaired
                                                              paired        compaired
                                                              domain of      to PAX3       (adult:)
                                               http://local   Pax-3 are     [5] [3] in     brain,
                                               host/cgi-      retained      response       blood,
                                               bin/biobas     [3] 86%       to insulin     colon,
                                               e/transfac/    identical     AKT-1          kidney,
                  ALV,    human,               7.4/bin/get    to            represses      ovary,
                  FKHR,   Homo      vertebrate TFProf.cgi     FKHRL1        transcripti    skeletal,
T02936   FOXO1a   FKH1.   sapiens   s          ?T02936        [2]           onal           muscle [2]
                                                                             may have
                                                                             regulatory
                                                                             roles in
                                                                             immune
                                                                             response
                                                                             [5] the
                                                                             serine/thr
                                                                             eonine
                                                                             kinase
                                                                             Akt
                                                                             prevents
                                                                             FOXO3a
                                                                             dependent

                                                                         transcripti
                                                                         on by
                                                                         phosphory
                                                                         lation
                                                                         (T32,
                                                                         S253),
                                                                         phosphory
                                                                         lated
                                                                         FOXA3a           (adult:)
                                                                         is               brain,
                                                                         retained         blood,
                                                                         in the           colon,
                                                http://local             cytoplasm        kidney,
                                                host/cgi-      86%        by              ovary,
                                                bin/biobas     identical binding to       skeletal,
                                                e/transfac/    to        the              muscle
                          human,                7.4/bin/get    FOXO1a scaffold            [4], T
                          Homo       vertebrate TFProf.cgi     <T02936> protein           helper
T02938   FOXO3a   FKHRL1. sapiens    s          ?T02938         [4]      14-3-3           cells [5]

                                                               translocati
                                                               on t(X
                                                               11)(q13
                                                               q23) with
                                                               the MLL
                                                               (mixed-
                                                http://local   lineage
                                                host/cgi-      leukemia)
                                                bin/biobas     gene can
                                                e/transfac/    cause
                           human,               7.4/bin/get    acute
                  AFX,     Homo      vertebrate TFProf.cgi     leukemia                   B-cells, T-
T03403   FOXO4    AFX-1.   sapiens   s          ?T03403        [1]                        cells [1]
                                                                    zinc
                                                                    finger
                                                                    region
                                                                    binds
                                                                    specificall
                                                                    y to DNA
                                                                    POZ
                                                                    (POx
                                                                    virus and
                                                                    Zinc
                                                                    finger)
                                                                    domain,
                                                                    which is a
                                                     http://local   protein-
                    zinc                             host/cgi-      protein
                    finger                           bin/biobas     contact
                    protein                          e/transfac/    region, is
                    with        human,               7.4/bin/get    inhibitory
                    interaction Homo      vertebrate TFProf.cgi     for DNA-
T01468   ZID         domain. sapiens      s          ?T01468        binding     NULL


                                                    http://local
                                                    host/cgi-
                                                    bin/biobas
                               rat,                 e/transfac/
                               Rattus               7.4/bin/get
         HP1 site   HP1 site   norvegicu vertebrate TFProf.cgi
T00379   factor     factor.    s         s          ?T00379                   NULL
                                                                           activator
                                                                           [2] may
                                                                           be
                                                                           involved
                                                                           in
                                                                           transcripti
                                                                           onal
                                                              6 zinc       initiation
                                                              fingers of   and
                                                              C2H2-        terminatio
                                                              type [3]     n at the c-
                                                              proline-     myc P2
                                                              /alanine-    promoter
                                                              rich         [1] may
                                                              region [1]   be an
                                                              may have     important
                                                              an N-        regulator
                                                              terminal     of TATA-
                                                              extension    less
               MAZ,                                           leading to   promoters
               ZF87,                                          a 87 kDa      [2] may
               Zif87,                                         protein as   function
               Myc-                                           mentioned    in
               associate                                       in [3]      establishin
               d zinc                                         homologo     g active
               finger                                         us to the    transcripti
               protein,                          http://local rodent       on
               Pur-1,                            host/cgi- factors         complexe
               purine-                           bin/biobas Pur-1          s on the
               binding                           e/transfac/ <T02303>      serotonin
               transcripti   human,              7.4/bin/get               1a
               on factor     Homo     vertebrate TFProf.cgi <T02304>       receptor
T00490   MAZ   1.            sapiens  s          ?T00490 [4]               gene        NULL
                                                              contains
                                                              zinc
                                                              fingers of
                                                              C2H2
                                                              type [1]
                                                              homologo
                                                              us to the
               Myc-                                           human
               associate                                      factor
               d zinc                                         MAZ
               finger                                         <T00490>
               protein,                          http://local [1]
               Pur-1,                            host/cgi- equivalent
               purine-                           bin/biobas in
               binding                           e/transfac/ hamster
               transcripti   mouse,              7.4/bin/get is
               on factor     Mus      vertebrate TFProf.cgi <T02304>
T02303   MAZ   1.            musculus s          ?T02303 [1]                         NULL
                                                                  protein
                                                                  sequence
                                                                  may be
                                                                  incomplet
                                                                  e [1]        activator
                                                                  contains     [2] binds
                                                                  zinc         to purine-
                                                                  fingers of   rich
                                                                  C2H2         region
               Myc-                                               type [2]     (GAGA-
               associate                                          homologo     box) in
               d zinc                                             us to the    insulin
               finger                                             human        and
               protein,                           http://local    factor       human
               Pur-1,        golden               host/cgi-       MAZ          islet
               purine-       (Syrian)             bin/biobas      <T00490>     amyloid
               binding       hamster,             e/transfac/      and to      polypeptid
               transcripti   Mesocrice            7.4/bin/get     <T02303>     e
               on factor     tus       vertebrate TFProf.cgi       in mouse    promoters
T02304   MAZ   1.            auratus   s          ?T02304         [2]           [2]       NULL




                                                                  class A
                                                                  type
                                                                  domain C-
                                                                  terminally
                                                                  adjacent
                                                                  to the
                                                                  bHLH
                                                                  motif may
                                                                  comprise
                                                                  a novel
                                                                  loop-helix
                                                                  motif in
                                                                  the trans-
                                                                  activating
                                                                  region as
                                                                  suggested                thymus,
                                                                   by                      T-cell
                                                                  similarity               lines;
                                                                  with E2A                 lower in
                                                                  and E2-2                 brain,
                                                   http://local   gene         transcripti kidney,
                                                   host/cgi-      products     onal        ovary;
                                                   bin/biobas     and          activator, moderate
                                                   e/transfac/    Daughterl    binding to in lung;
               HTF4,         human,                7.4/bin/get    ess          E box       low in
               HTF4A,        Homo       vertebrate TFProf.cgi     (Drosophil   elements skeletal
T01503   HEB   TCF-12.       sapiens    s          ?T01503        a) [2]       [4]         muscle [4]
                                                                all
                                                                identified
                                                                SOX
                                                                proteins
                                                                contain
                                                                HMG          may play
                                                                domains      a key role
                                                                which        in bone
                                                                facilitate   formation
                                                                sequence-    and testis
                                                                specific     developm
                                                                DNA-         ent [2]
                                                                binding      gene
                                                                and          found
                                                                share        close to
                                                                more         the
                                                                than 50%     breakpoint
                                                                identity      of t(2
                                                                with the     17)(q35
                                                                HMG          q23-24)
                                                                domain of    chromoso
                                                                SRY          mal
                                                                (human       translocati
                                                                testis-      on
                                                                determinin   causing       highest
                                                                g factor)    campomel      levels in
                                                 http://local   most of      ic            adult
                                                 host/cgi-      the SOX      dysplasia,    testis,
                 SRY-                            bin/biobas     proteins     a skeletal    lower in
                 related                         e/transfac/    share a      malformati    fetal
                 HMG-box human,                  7.4/bin/get    core DNA-    on            brain,
                 protein 9, Homo      vertebrate TFProf.cgi     binding      syndrome      liver,
T01853   SOX-9   SOX9.      sapiens   s          ?T01853        sequence     [2] [3]       kidney [3]
                                                              solution
                                                              structure
                                                              similar to
                                                              that of
                                                              HMG1 [1]
                                                              overlappin
                                                              g DNA-
                                                              binding
                                                              specificity
                                                              with SRY
                                                              [2] binds
                                                              to
                                                              AACAAT
                                                              with KD =
                                                              1 nM [1]
                                                              DNA-
                                                              binding in
                                                              a 1:1
                                                              stoichiom
                                                              etry does     post-
                                             http://local     not affect    meiotic
                                             host/cgi-        the           germ
                                             bin/biobas       protein       cells;
                 SRY-                        e/transfac/      structure,    round
                 related mouse,              7.4/bin/get      but bends     spermatid
                 HMG-box Mus      vertebrate TFProf.cgi       the DNA       s (highest
T01429   Sox-5   gene 5. musculus s          ?T01429          [1]           level) [2]


                                               http://local
                                               host/cgi-
                 EF-C,                         bin/biobas
                 RFX, RF-                      e/transfac/                  ubiquitous
                 X,        mouse,              7.4/bin/get                  ; highest
                 enhancer Mus       vertebrate TFProf.cgi                   level in
T01666   RFX1    factor C. musculus s          ?T01666                      testis [1]
                                                              member        homodime
                                                              of winged-    rs can
                                                              helix         function
                                                              class of      as
                                                              helix-turn-   activators
                                                              helix         or
                                                              superclas     repressor
                                                              s of          s
                                                              factors [2]   depending
                                                              the DBD        on the
                                                              exhibits a    nature of
                                                              weak          interaction
                                                              sequence      s
                                                              similarity    between
                                                              to the        two
                                                              bHLH          subunits,
                                                              domain        two
                                                              consensu      distinct
                                                              s and is      types of
                                                              predicted     homodime
                                                              to            rs can be
                                                              constitute    formed
                                                              two           which are
                                                              amphipath     different
                                                              ic helices    in their
                                                              and a         function
                                               http://local   linking       [5] [7] [6]   ubiquitous
                EF-C,                          host/cgi-      loop [14]     preferenti    , highly
                RFX, RF-                       bin/biobas     it binds to   al binding    expressed
                X,                             e/transfac/    DNA as a      to             in
                enhancer human,                7.4/bin/get    dimer,        methylate     primary
                factor C, Homo      vertebrate TFProf.cgi     but           d             eosinophil
T01673   RFX1   hRFX1.    sapiens   s          ?T01673        dimerizati    sequence      s [4]
                                                                              potent
                                                                              activator
                                                                              as homo-
                                                                              or
                                                                              heterodim
                                                                              er with
                                                                              RelA
                                                                              <T00594>
                                                                               [10] [3],
                                                                overlappin    but may
                                                                g DNA-        also
                                                                binding       repress
                                                                specificity   trans-
                                                                with NF-      activation
                                                                kappaB        by
                                                                <T00590>      induced
                                                                 exclusive    RelA [2]
                                                                binding       relA gene
                                                                to, e. g.,    is
                                                                intronic      activated
                                                                enhancer      by RelA,
                                                                of IFN-       but
                                                                gamma         repressed
                                                                gene           by c-Rel
                                                                (AGGGAT       itself [2]
                                                                TT) [9]       DNA-
                                                 http://local   trans-        binding
                                                 host/cgi-      activation    by c-Rel
                                                 bin/biobas     through       is
                 c-Rel,                          e/transfac/    physical      induced
                 HIVEN86 human,                  7.4/bin/get    interaction   by HTLV-
                 A, p82(hc- Homo      vertebrate TFProf.cgi      with TBP     I Tax [4]
T00168   c-Rel   rel), p68. sapiens   s          ?T00168        [5]           which      (HeLa)
                                                                c-Rel
                                                                heterodim
                                                                ers with      potent
                                                                NF-           acivator
                                                                kappaB1       [6] [5]
                                                                (p50)         early
                                                                prevail in    growth
                                                                mature B      response
                                                                cells in      gene [8]
                                                                contrast      may
                                                                to pre-B      substitute
                                                                cells,        RelA
                                                                where         (p65)
                                                                p50/RelA      during B-
                                                                heterodim     cell
                                                                ers           maturatio
                                                                predomin      n thus
                                                                ate [1] c-    contributin
                                                                Rel/p50       g to the
                                                                dimers        constitutiv
                                                                bind 20-      e
                                                                fold more     expressio
                                                                stably to     n of
                                                                the           immunogl
                                                                intronic      obulin
                                                                kappaB        genes [1]
                                                http://local    site of the   c-rel
                                                host/cgi-       Igkappa       expressio
                                                bin/biobas      gene than     n is
                 c-Rel,                         e/transfac/     p50/RelA      augmente
                 HIVEN86 mouse,                 7.4/bin/get     dimers [1]    d in
                 A, p82(hc- Mus      vertebrate TFProf.cgi      the potent    mature B
T00169   c-Rel   rel), p68. musculus s          ?T00169         C-            cells [1]   NULL

                                                                                         high
                                                                                         levels:
                                                 http://local                            apoptotic
                 c-Rel,                          host/cgi-      trans-                   or
                 p82(hc-                         bin/biobas     activation               autophago
                 rel), p68,                      e/transfac/    domains                  cytotic
                 HIVEN86 chick,                  7.4/bin/get    contact      potent      cells; low:
                 A          Gallus    vertebrate TFProf.cgi     TBP          activator   ubiquitous
T01154   c-Rel   (human). gallus      s          ?T01154        directly [2] [5] [9]      [1]
                                                             for
                                                             expressio
                                                             n in teeth,
                                                             see [6]
                                                             rescues
                                                             unc-30
                                                             <T03371>
                                                              mutant
                                                             phenotype
                                                              of C.
                                                             elegans
                                                             [2]
                                                             regulator
                                                             of
                                              http://local   GABAergi
                 Ptx-2,                       host/cgi-      c
                 Pitx2,                       bin/biobas     differentiat
                 RGS,                         e/transfac/    ion during
                 Otlx2,   mouse,              7.4/bin/get    neural
                 RIEG,    Mus      vertebrate TFProf.cgi     developm
T02410   Pitx2   Ptx2.    musculus s          ?T02410        ent [2]      NULL
                                                              POU1F1 mutations
                                                              (Pit-1)      cause
                                                              <T00691> Rieger
                                                                           syndrome
                                                              physically (ocular
                                                              interacts anterior
                                                              with         chamber
                                                              PITX2 to anomalies
                                                              facititate    causing
                                                              DNA          glaucoma,
                                                              binding       dental
                                                              [3]          hypoplasi
                                                              mutant       a, mild
                                                              PITX2        craniofaci
                                                              (T68P)       al
                                                              has          dysmorphi
                                                              reduced sm,
                                                              DNA          umbilical
                                                              binding      stump
                                                              specificity, abnormalit
                                                               lacks       ies,
                                                              transactiv abnormal
                                                              ation        cardiac,
                                                              activity [3] limb and
                                                              mutant       pituitary
                                                              PITX2        developm
                                               http://local   (L54Q) is ent) [4]
                 Ptx-2,                        host/cgi-      an           activator,
                 Pitx2,                        bin/biobas     unstable interacts
                 RGS,                          e/transfac/    protein [3] with
                 Otlx2,   human,               7.4/bin/get    C-           POUF1
                 RIEG,    Homo      vertebrate TFProf.cgi     terminus (Pit-1)
T02413   PITX2   Ptx2.    sapiens   s          ?T02413        represses <T00691> NULL
                                                                             repressor
                                                                             of
                                                                             apolipopro
                                                                             tein AI
                                                                             and CIII
                                                                             genes
                                                                             [11], of
                                                                forms        the
                                                                homodime     human
                                                                rs, can      erythropoi
                                                                bind as      etin
                                                                monomer      promoter
                                                                or           [7]
                                                                homodime     activator
                                                                r [6] loss   of the
                                                                of           mouse
                                                                dimerizati   LPL
                                                                on           promoter
                                                                function     [4],
                                                                leads to a   FABPI
                                                                loss of      promoter
                                                                DNA-         [8], rat
                                                                binding      CYP7A
                 ARP-1,                                         unless it    [2],
                 COUP-                                          is C-        salmon
                 beta,                                          terminally   HNF-1
                 apolipopro                      http://local   truncated    promoter
                 tein AI                         host/cgi-      to AA 171    [1]
                 regulatory                      bin/biobas     can bind     participate
                 protein,                        e/transfac/    to DR0,      s in
                 NR2F2,     human,               7.4/bin/get    DR4          regulation
                 COUP-      Homo      vertebrate TFProf.cgi     elements     of lipid    widesprea
T00045   ARP-1   TF II.     sapiens   s          ?T00045        [2]          metabolis d
                                                                          activator
                                                                          as a
                                                                          heterodim
                                                                          er with
                                                                          RXR-
                                                                          alpha
                                                                          regulator
                                                                          of the
                                                                          physiologi
                                                                          cal
                                                                          response
                                                                          to
                                                                          xenobiotic
                                                                          s in a
                                                                          complex
                                                                          cross-talk
                                                                          with PXR
                                                                          (NR1I2)
                                                            forms         [3] [2]
                                                            heterodim     activating
                                                            ers with      ligand:
                                                            RXR-          xenobiotic
               NR1I3,                                       alpha,         5beta-
               phenobar                                     which is      pregnane-    preferenti
               bital                                        necessary     3,20-        ally in
               receptor,                                      for DNA     dione,       liver; low
               constitutiv                   http://local   binding       that is      levels in
               e                             host/cgi-      and           common       heart and
               androstan                     bin/biobas     transcripti   for the      muscle,
               e                             e/transfac/    on            human        lesser
               receptor, human,              7.4/bin/get    activation    and          levels in
               MB67        Homo   vertebrate TFProf.cgi     <T05676>      mouse        kidney
T02261   CAR   (human). sapiens   s          ?T02261        .             PXR-1 [3]    and lung
                                                                    activator
                                                                    [5] [4] [3]
                                                                    [1]
                                                                    recognize
                                                                    s retinoic
                                                                    acid
                                                                    response
                                                                    elements
                                                                    (RAREs)
                                                                    of DR5
                                                                    type [5]
                                                                    [3]
                                                                    recognize
                                                                    s DR4
                                                                    elements
                                                                    [4] [3] [1],
                                                                    DR3
                                                                    elements
                                                                    [3] [1],
                                                                    ER6
                                                       heterodim    elements
                                                       er, for      [3]
                                                       individual   activates
                                                       polypeptid   gene
                                                       es see       encoding
                                                       mouse        the
                                       http://local    CAR          enzyme
                                       host/cgi-       <T05687>     of the
                                       bin/biobas       and         peroxisom
                                       e/transfac/     mouse        al beta-
                   mouse,              7.4/bin/get     RXR-         oxidation
         CAR:RXR   Mus      vertebrate TFProf.cgi      alpha        pathway,
T05257   -alpha    musculus s          ?T05257         <T01331>     hydratase/ NULL

                                                       heterodim
                                                       er for
                                                       individual
                                                       polypeptid
                                        http://local   es see rat
                                        host/cgi-      CAR
                                        bin/biobas     <T05312>
                   rat,                 e/transfac/     and rat
                   Rattus               7.4/bin/get    RXR-
         CAR:RXR   norvegicu vertebrate TFProf.cgi     alpha      activator
T05315   -alpha    s         s          ?T05315        <T04383> [1]           NULL
                                                                                activator
                                                                                binds to
                                                                                and
                                                                                activates
                                                                                transcripti
                                                                                on
                                                                                through
                                                                                different
                                                                                types of
                                                                                response
                                                                                elements:
                                                                                DR5/RAR
                                                                                E, DR4
                                                                                [2] [1] [4],
                                                                                DR3 [3],
                                                                                ER6/IR6
                                                                                [3] [4]
                                                                                activates
                                                                                cyp2b
                                                                                and
                                                                   heterodim    cyp3a
                                                                   er for       genes in
                                                                   individual   response
                                                                   polypeptid   to
                                                                   es see       phenobar
                                                                   human        bital [4]
                                                    http://local   CAR          regulator
                                                    host/cgi-      <T02261>     of
                                                    bin/biobas      and         xenobiotic
                                                    e/transfac/    human         response
                               human,               7.4/bin/get    RXR-         in a
         CAR:RXR               Homo      vertebrate TFProf.cgi     alpha        complex
T05676   -alpha                sapiens   s          ?T05676        <T01345>     interplay NULL

                   COUP,
                   COUP-
                   TF,
                   chicken                          http://local                member
                   ovalbumin                        host/cgi-                   of the
                                                    bin/biobas                  steroid
                   upstream rat,                    e/transfac/                 hormone
                   promoter Rattus                  7.4/bin/get mixture of      receptor
                   transcripti norvegicu vertebrate TFProf.cgi different        superfamil
T00147   COUP      on factor. s          s          ?T00147 isoforms            y          NULL
                   COUP-
                   TF,
                   chicken                      http://local
                   ovalbumin                    host/cgi-
                                                bin/biobas
                 upstream                       e/transfac/
                 promoter mouse,                7.4/bin/get
                 transcripti Mus     vertebrate TFProf.cgi
T00994   COUP-TF on factor. musculus s          ?T00994                     NULL


                                                                  repressor
                                                                  represses
                                                                  RXR-
                                                                  mediated
                                                                  activation
                                                                  and
                                                                  retinoic
                                                                  acid
                   COUP,                                          responses
                   COUP-                                           also
                   TF,                                            antagoniz
                   EAR3,                                          es HNF-4-
                   COUP-                                          mediated
                   alpha,                                         activation
                   NR2F1,                                         [6] [3]
                   chicken                         http://local   competitiv
                   ovalbumin                       host/cgi-      ely binds
                                                   bin/biobas     to XRE
                   upstream                        e/transfac/    with
                   promoter human,                 7.4/bin/get    AhR:Arnt
         COUP-     transcripti Homo     vertebrate TFProf.cgi     heterodim
T00149   TF1       on factor. sapiens   s          ?T00149        er [1]     (HeLa)
                                                                             activation
                                                                             by
                                                                             oxysterols
                                                                              (natural
                                                                             ligands):
                                                                             24(S),25-
                                                                             epoxychol
                                                                             esterol,
                                                                             24(S)-
                                                                heterodim    hydroxych
                                                                erization    olesterol
                                                                with RXR-    and
                                                                alpha        22(R)-
                                                                <T01345>     hydroxych
                                                                 [6]:        olesterol
                                                                binding of   [4] [3]
                                                                this         ligand
                                                                heterodim    selectivity
                                                                er to DR4-   distinct
                                                                like         from
                 NR1H3,                                         sequence     isoform
                 LXR, liver                                     s in         <T04453>
                 X                                              contrast      (stronger
                 receptor                                       no           binding to
                 alpha,                                         formation    5,6-
                 nuclear                                        of a         24(S),25-
                 orphan                          http://local   biological   di-
                 receptor                        host/cgi-      active       epoxychol
                 LXR-                            bin/biobas     heterodim    esterol)
                 alpha,                          e/transfac/    er           [3]
                 LXRA,      human,               7.4/bin/get    together     heterodim
         LXR-    LXR A,     Homo      vertebrate TFProf.cgi     with RAR-    er with
T02752   alpha   LXR-A.     sapiens   s          ?T02752        alpha [6].   RXR-        NULL
                                                                            activator
                                                                            as a
                                                                            heterodim
                                                                            er with
                                                                            RXR-
                                                                            alpha [1]
                                                                            [3] seems
                                                                            to link
                                                                            fatty acid
                                                                            and
                                                                            cholestero
                                                                            l
                                                              forms         metabolis
                 NR1H3,                                       heterodim     m via
                 RLD1,                                        ers with      induction
                 LXR,                                         RXR-          of
                 oxysterol                                    alpha [1]     SREBP-        (embryo:)
                 receptor                                     [3]           1c gene       probably
                 LXRalpha,                                    conflict in   expressio     weak
                  liver X                                     protein       n             expressio
                 receptor                                     sequence      <G002466      n starting
                 alpha,                                       between       > [1]         at
                 nuclear                                      EMBL          activates     embryonic
                 orphan                                       entry         transcripti    day 13.5
                 receptor                                     #AJ13259      on of (rat)   that
                 LXR-                                         9 (pos.       cholestero    increases
                 alpha,                        http://local   399:R)        l 7alpha-     in
                 oxysterol                     host/cgi-      and           hydroxyla     abundanc
                 receptor                      bin/biobas     SWISSPR       se gene       e up to
                 LXR-                          e/transfac/    OT entry      (CYP7A)       birth [2];
                 alpha,    mouse,              7.4/bin/get    #Q9Z0Y9       <G001194      peritoneal
         LXR-    LXR A,    Mus      vertebrate TFProf.cgi     (pos.         > in vitro    macropha
T04430   alpha   LXR-A.    musculus s          ?T04430        399:P).       (CYP7A        ges [4]
                                                                                            (adult:)
                                                                                            strong in
                                                                                            spleen [1]
                                                                                            [2],
                                                                                            pituitary
                                                                                            gland, fat
                                                                                            tissue,
                                                                                            lung [2]
                                                                                            and in
                                                                                            metabolic
                                                                                            organs
                                                                 P-Box                      such as
                                                                 (contribut                 liver,
                 NR1H3,                                          es in                      kidney,
                 RLD1,                                           general to   as            intestine
                 LXR,                                            DNA-         heterodim     [1]; weak
                 oxysterol                                       binding      er with rat   in
                 receptor                                        specifity)   RXRalpha      prostate,
                 LXRalpha,                                       in DNA-                    skin [2]
                  liver X                                        binding      <T04383>      and
                 receptor                                        domain is                  probably
                 alpha,                                          conserved    transcripti   in
                 nuclear                                          [2]         onal          adrenals
                 orphan                                          probably     activation    [1],
                 receptor                                        weak         of            stomach
                 LXR-                                            binding to   reporter      [2];
                 alpha,                           http://local   retinoic-    genes         unclear
                 oxysterol                        host/cgi-      acid         linked to     wether
                 receptor                         bin/biobas     response     artificial    low levels
                 LXR-        rat,                 e/transfac/    element      DR-4 like     in testis
                 alpha,      Rattus               7.4/bin/get    beta         repeat        are
         LXR-    LXR A,      norvegicu vertebrate TFProf.cgi     (RARE-       <R09934>      present
T04434   alpha   LXR-A.      s         s          ?T04434        beta)         [2]          [2] or not
                                                                     activator
                                                                     upon
                                                                     induction
                                                                     by
                                                                     oxysterols
                                                                       [2] [1]
                                                                     classical
                                                                     binding
                                                                     DNA
                                                                     element
                                                                     is DR4
                                                                     regulates
                                                        heterodim    cholestero
                                                        er, for      l
                                                        individual   catabolis
                                                        polypeptid   m into
                                                        es see       bile acids
                                                        mouse        by
                                                        LXR-         induction
                                        http://local    alpha        of CYP7A
                                        host/cgi-       <T04430>     [2] can
                                        bin/biobas       and         act
                                        e/transfac/     mouse        synergistic
         LXR-       mouse,              7.4/bin/get     RXR-         ally with
         alpha:RX   Mus      vertebrate TFProf.cgi      alpha        LRH-1
T05320   R-alpha    musculus s          ?T05320         <T01331>     (FTF) [2] NULL
                                                                     activator
                                                                     [1] [2]
                                                                     classical
                                                                     binding
                                                                     DNA
                                                        heterodim    element
                                                        er, for      is DR4
                                                        individual   regulates
                                                        polypeptid   lipid
                                                        es see       metabolis
                                                        human        m in liver
                                                        LXR-         [1]
                                         http://local   alpha        regulates
                                         host/cgi-      <T02752>     cholestero
                                         bin/biobas      and         l efflux
                                         e/transfac/    human        from lipid-
         LXR-       human,               7.4/bin/get    RXR-         loaded
         alpha:RX   Homo      vertebrate TFProf.cgi     alpha        macropha
T05324   R-alpha    sapiens   s          ?T05324        <T01345>     ges [2]     NULL
                                                                 heterodim
                                                                 er, for
                                                                 individual
                                                                 polypeptid
                                                                 es see rat
                                                 http://local    LXR-
                                                 host/cgi-       alpha
                                                 bin/biobas      <T04434>
                            rat,                 e/transfac/      and rat
         LXR-               Rattus               7.4/bin/get     RXR-
         alpha:RX           norvegicu vertebrate TFProf.cgi      alpha      activator
T05357   R-alpha            s         s          ?T05357                    functional NULL
                                                                 <T04383> [1]
                                                                            activation
                                                                            by
                                                                            oxysterols
                                                                             24(S),25-
                                                                            epoxychol
                                                                            esterol,
                                                                            24(S)-
                                                                            hydroxych
                                                                            olesterol
                                                                            and
                                                                            22(R)-
                                                                            hydroxych
                                                                            olesterol
                                                                            [3] [2]
                  NR1H2,                                                    ligand
                  oxysterol                                                 selectivity
                  receptor                                                  distinct
                  LXR-                                                      from
                  beta,                                                     isoform
                  nuclear                                                   <T02752>
                  orphan                                                     (weaker
                  receptor                                                  binding to
                  LXR-                                                      5,6-
                  beta,                                                     24(S),25-
                  ubiquitous                                                di-
                  ly                              http://local              epoxychol
                  expressed                       host/cgi-                 esterol)
                   nuclear                        bin/biobas                [2]
                  receptor,                       e/transfac/               heterodim
                  LXRB,      human,               7.4/bin/get               erization
                  UR, LXR Homo         vertebrate TFProf.cgi                with RXR-
T04453   LXR-beta B, NER. sapiens      s          ?T04453                   alpha       NULL
                  NR1H2,
                  oxysterol
                  receptor
                  LXR-                                                        seems to
                  beta,                                          binds to     link fatty
                  nuclear                                        DNA          acid and
                  orphan                                         elements     cholestero
                  receptor                                       as a         l
                  LXR-                                           heterodim    metabolis
                  beta,                                          er with      m via
                  ubiquitous                                     RXR-         induction
                  ly                                             alpha,       of
                  expressed                                      see          SREBP-
                   nuclear                                       <T05701>     1c gene
                  receptor,                                       [2] does    expressio
                  orphan                       http://local      not bind     n
                  nuclear                      host/cgi-         to DNA       <G002466
                  receptor                     bin/biobas        as a         > (as a
                  OR-1,                        e/transfac/       monomer      heterodim
                  LXRB,      mouse,            7.4/bin/get       or           er with     peritoneal
                  UR, LXR Mus       vertebrate TFProf.cgi        homodime     RXR-        macropha
T04467   LXR-beta B, NER. musculus s           ?T04467           r [3].       alpha) [1]. ges [2]

                                                                 heterodim
                                                                 er, for      activator
                                                                 individual   [1]
                                                                 polypeptid   classical
                                                                 es see       binding
                                                                 human        DNA
                                                  http://local   LXR-beta     element
                                                  host/cgi-      <T04453>     is DR4 [1]
                                                  bin/biobas      and         [2]
                                                  e/transfac/    human        activates
         LXR-                human,               7.4/bin/get    RXR-         human
         beta:RXR-           Homo      vertebrate TFProf.cgi     alpha        CETP
T05325   alpha               sapiens   s          ?T05325        <T01345>     gene [1] NULL
                                                               for DNA      activator
                                                               binding      as a
                                                               requires     heterodim
                                                               dimerizati   er with
                                                               on with      RXR-
                                                               RXR-         alpha
                                                               alpha,       regulator
                                                               see          of the
                                                               <T05671>     physiologi
                                                                splice      cal
                                                               variants     response
                                                               are          to
                                                               known,       xenobiotic
                                                               human        s in a
                                                               SXR          complex
                                                               <T04610>     cross-talk
                                                               , PXR-2      with CAR
                                                               <T04641>     (NR1I3)
                                                                forms       [8] [6]
                                                               heterodim    regulates
                                                               ers with     physiologi
                                                               RXR-         cal
                                                               alpha for    response
                                                               DNA          to LCA
                                                               binding      (toxic bile
                                                               and gene     acid)
                                                http://local   activation   possibly
                 NR1I2,                         host/cgi-      the          in the
                 pregnane                       bin/biobas     crystal      cooperatio
                 X                              e/transfac/    structure    n with
                 receptor, human,               7.4/bin/get    of LBD in    FXR
                 hPAR-1, Homo        vertebrate TFProf.cgi     complex      (NR1H4),
T04617   PXR-1   PAR-1.    sapiens   s          ?T04617        with the     for         NULL
                                                            for DNA       activator
                                                            binding       as a
                                                            requires      heterodim
                                                            dimerizati    er with
                                                            on with       RXR-
                                                            RXR-          alpha
                                                            alpha,        regulator
                                                            see           of the
                                                            <T05673>      physiologi
                                                             direct       cal
                                                            interaction   response
                                                             of ligand-   to
                                                            binding       xenobiotic
                                                            domain        s in a
                                                            with          complex
                                                            steroid       cross-talk
                                                            ligands       with CAR
                                                            (e.g.         (NR1I3)
                                                            pregnenol     [6]
                                                            one,          regulates
                                                            pregnenol     physiologi
                                                            one           cal
                                                            16alpha-      response
                                                            carbonitril   to LCA
                                                            e) [1]        (toxic bile
                                                            ligand-       acid)
                                               http://local dependent     possibly
                                               host/cgi-                  in the
                 NR1I2,                        bin/biobas interaction     cooperatio
                 pregnane                      e/transfac/ of ligand-     n with
                 X         mouse,              7.4/bin/get binding        FXR
                 receptor, Mus      vertebrate TFProf.cgi domain          (NR1H4)
T04618   PXR-1   PXR.      musculus s          ?T04618 with               [4]         NULL
                                                                   activator
                                                                   regulator
                                                                   of the
                                                                   xenobiotic
                                                                    response
                                                                   in a
                                                                   complex
                                                                   interplay
                                                                   with
                                                                   CAR:RXR
                                                                   -alpha [3]
                                                                   [1]
                                                                   activates
                                                                   transcripti
                                                                   on in
                                                                   response
                                                                   to
                                                                   steroids,
                                                                   clotrimazo
                                                                   le,
                                                      heterodim    rifampicin
                                                      er, for      provides
                                                      individual   gene
                                                      polypeptid   induction
                                                      es see       by toxic
                                                      human        bile acid
                                       http://local   PXR-1        LCA [2]
                                       host/cgi-      <T04617>     interacts
                                       bin/biobas      and         efficiently
                                       e/transfac/    human        and
         PXR-     human,               7.4/bin/get    RXR-         provides
         1:RXR-   Homo      vertebrate TFProf.cgi     alpha        gene
T05671   alpha    sapiens   s          ?T05671        <T01345>     activation NULL
                                                                 activator
                                                                 activates
                                                                 transcripti
                                                                 on in
                                                                 response
                                                                 to
                                                                 steroids
                                                                 and
                                                                 xenobiotic
                                                                 s
                                                                 regulator
                                                                 of liver-
                                                                 specific
                                                                 expressio
                                                                 n of
                                                                 genes
                                                                 encoding
                                                                 enzymes
                                                                 of
                                                      heterodim xenobiotic
                                                      er, for
                                                      individual metabolis
                                                      polypeptid m [3] [2]
                                                      es see     [4] [1] has
                                                      mouse      been
                                                      PXR-1      shown to
                                      http://local    <T04618> bind
                                      host/cgi-        and       different
                                      bin/biobas      mouse      DNA
                                      e/transfac/     RXR-       elements:
         PXR-     mouse,              7.4/bin/get     alpha      DR3 [3]
         1:RXR-   Mus      vertebrate TFProf.cgi      <T01331> [1], DR4
T05673   alpha    musculus s          ?T05673         .          [2] [1],    NULL


                                                      heterodim
                                                      er, for
                                                      individual
                                                      polypeptid
                                                      es see
                                       http://local   human
                                       host/cgi-      PXR-1
                                       bin/biobas     <T04617>
                                       e/transfac/     and
         PXR-     human,               7.4/bin/get    human
         1:RXR-   Homo      vertebrate TFProf.cgi     RXR-beta
T05672   beta     sapiens   s          ?T05672        <T01334>             NULL
                                                                        smaller
                                                                        range of
                                                                        activating
                                                                        ligands
                                                                        than
                                                                        isoform
                                                                        <T04618>
                                                                         probably
                                                                        due to
                                                                        shorter
                                                                        ligand-
                                                                        binding
                                                                        domain
                                                                        [1]
                                                                        activating
                                                                        ligands:
                                                                        dexameth
                                                                        asone-t-
                                                                        butyl-
                                                                        acetate
                                                                        (artificial
                                                http://local            ligand),
                                                host/cgi-               5beta-
                  NR1I2,                        bin/biobas              3,20-
                  pregnane                      e/transfac/             dione
                  X         mouse,              7.4/bin/get             (naturally
                  receptor, Mus      vertebrate TFProf.cgi              occuring)
T04619   PXR-2    PXR.      musculus s          ?T04619                 [1]         NULL
                                                                        activator
                                                                        activates
                                                                        transcripti
                                                                        on in
                                                                        response
                                                                        to
                                                                        steroids
                                                                        and
                                                                        xenobiotic
                                                               heterodims
                                                               er, for  regulator
                                                                        of liver-
                                                               individual
                                                                        specific
                                                               polypeptid
                                                               es see   expressio
                                                               mouse    n of
                                                               PXR-2    genes
                                                http://local   <T04619> encoding
                                                host/cgi-       and     enzymes
                                                bin/biobas     mouse    of
                                                e/transfac/    RXR-     xenobiotic
         PXR-               mouse,              7.4/bin/get    alpha
         2:RXR-             Mus      vertebrate TFProf.cgi     <T01331> metabolis
T05674   alpha              musculus s          ?T05674        .          m [1]   NULL
                                                                    two splice
                                                                    variants
                                                                    are
                                                     http://local   known
                    retinoic                         host/cgi-      RAR-
                    acid                             bin/biobas     alpha1
                    receptor                         e/transfac/    <T00719>
                    alpha,     human,                7.4/bin/get     and RAR-
         RAR-       NR1B1,     Homo       vertebrate TFProf.cgi     alpha2
T05299   alpha      RARa.      sapiens    s          ?T05299        <T05298>             NULL

                                                                    heterodim
                                                                    er for
                                                                    individual
                                                                    polypeptid
                                                                    es see rat   binds to
                                                    http://local    RAR-         the
                                                    host/cgi-       alpha        hormone
                                                    bin/biobas      <T05274>     responsiv
                               rat,                 e/transfac/      and rat     e element
         RAR-                  Rattus               7.4/bin/get     RXR-         of HNF-
         alpha:RX              norvegicu vertebrate TFProf.cgi      alpha        4alpha
T05273   R-alpha               s         s          ?T05273         <T04383>     gene [1] NULL
                                                        heterodim
                                                        er for
                                                        individual
                                                        polypeptid
                                                        es see
                                                        human
                                                        RAR-
                                                        alpha
                                                        <T05299>
                                                         and
                                                        human
                                                        RXR-
                                                        alpha
                                                        <T01345>

                                                        heterodim
                                                        er
                                                        formation
                                                        is strictly
                                                        DNA-
                                                        dependent
                                                         [1] RXR      activator
                                                        binds to      in
                                                        the           response
                                                        downstrea     to retinoic
                                                        m half-       acid [2]
                                         http://local   site [1]      binds to
                                         host/cgi-      specific      DR1
                                         bin/biobas     protein-      repeats
                                         e/transfac/    DNA           [1] binds
         RAR-       human,               7.4/bin/get    interaction   to DR5
         alpha:RX   Homo      vertebrate TFProf.cgi     s are         repeats
T05300   R-alpha    sapiens   s          ?T05300        more          [2]         NULL

                                                        heterodim
                                                        er for
                                                        individual
                                                        polypeptid
                                                        es see
                                                        human
                                                        RAR-
                                         http://local   alpha
                                         host/cgi-      <T05299>
                                         bin/biobas      and
                                         e/transfac/    human
         RAR-       human,               7.4/bin/get    RXR-
         alpha:RX   Homo      vertebrate TFProf.cgi     gamma      activator
T05370   R-gamma    sapiens   s          ?T05370        <T04807> [1]            NULL
                                                                            member
                                                                            of the
                                                                            steroid
                                                                            hormone
                                                                            receptor
                                                                            superfamil
                                                                            y
                                                                            negative
                                                                            regulator
                                                                            of AP-1
                                                                            responsiv
                                                                            e genes,
                                                                            dependent
                                                                             on the
                                                                            DNA-
                                                                            binding
                                                                            domain of
                                                                            RAR and
                                                                            possibly
                                                                            via an
                                                                            unproducti
                                                                            ve
                                                                            complex
                                                                            with c-
                                                                            Jun 1st
                                                                            zinc
                  RAR-                            http://local              finger is
                  alpha,                          host/cgi-                 the
                  retinoic                        bin/biobas                determina
                  acid                            e/transfac/               nt of half-
                  receptor   human,               7.4/bin/get               site
         RAR-     alpha,     Homo      vertebrate TFProf.cgi     two splice spacing
T00719   alpha1   NR1B1.     sapiens   s          ?T00719        variants   favouring NULL

                                                                         negative
                                                                         regulation
                                                                         of AP-1
                                                                         responsiv
                                                                         e genes
                                                                         activator
                                                                         of
                                                                         HOXA1
                                                                         <T01696>
                                                                          by
                                                                         binding to
                                                                         a3
                  RAR-                            http://local           enhancer
                  beta,                           host/cgi-              retinoic
                  retinoic                        bin/biobas 3 N-        acid
                  acid                            e/transfac/ terminally responsiv
                  receptor   human,               7.4/bin/get differing  e element
                  beta,      Homo      vertebrate TFProf.cgi splice      (RARE)
T00721   RAR-beta NR1B2.     sapiens   s          ?T00721 variants       [5]        NULL
                                                                         member
                                                                         of the
                                                                         steroid
                                                                         hormone
                                                                         receptor
                                                                         superfamil
                                                                         y3
                                                                         subtypes
                                                                         (alpha,
                                                                         beta,
                                                                         gamma)
                                                                         activator
                                                                         of
                                                              two N-     HOXA1
                                                              terminally <T01696>
                                                              differing   by
                                                              splice     binding to
                                                              variants   a3
                 RAR-                            http://local (RAR-      enhancer
                 gamma,                          host/cgi- gamma1 retinoic
                 retinoic                        bin/biobas and -        acid
                 acid                            e/transfac/ gamma2) responsiv
                 receptor   human,               7.4/bin/get of 454      e element
         RAR-    gamma,     Homo      vertebrate TFProf.cgi and 443 (RARE)
T00720   gamma   NR1B3.     sapiens   s          ?T00720 AA              [2]        NULL


                                                http://local
                 RAR-                           host/cgi-               expressio
                 gamma,                         bin/biobas              n is
                 retinoic                       e/transfac/             regulated
                 acid       mouse,              7.4/bin/get             by
         RAR-    receptor   Mus      vertebrate TFProf.cgi two splice   retinoic
T01329   gamma   gamma.     musculus s          ?T01329 variants        acid      NULL
                                                                  binds to     natural        (embryo:)
                                                                  DNA as a     occuring       expressed
                                                                  homodime     high            on
                                                                  r or as a    affinity       E10.5,
                                                                  heterodim    ligand         E11.5,
                                                                  er with a    (retinoid      E12.5,
                                                                  number       X) is 9-cis    E13.5,
                                                                  of           retinoic       E14.5,
                                                                  different    acid           E15.5,
                                                                  nuclear      which          E16.5,
                                                                  receptors:   induces        E17.5,
                                                                   RAR-        transcacti     E18.5 [6];
                                                                  alpha, -     vation         E 16.5 (in
                                                                  beta, -      activity [6]   situ):
                                                                  gamma,       responds       strong
                                                                  TR-alpha,    to a           signals in
                                                                  ARP-1,       variety of     epithelia
                                                                  PPAR-        endogeno       of
                                                                  alpha,       us             digestive
                                                                  PPAR-        retinoids,     system,
                                                                  gamma,       but again      skin, liver
                                                                  VDR,         9-cis          and
                                                                  CAR,         retinoic       weaker
                                                                  LXR-         acid is        signals in
                                                                  alpah,       most           central
                                                                  LXR-         potent         nervous
                                                  http://local    beta,        ligand         system,
                   retinoid X                     host/cgi-       FXR,         with high      skeleton
                   receptor                       bin/biobas      FXRbeta      transactiv     [6];
                   alpha,                         e/transfac/     for          ation          (adult:)
                   RXR-       mouse,              7.4/bin/get     heterodim    activity       liver;
         RXR-      alpha,     Mus      vertebrate TFProf.cgi      ers, see     (up to 40-     kidney,
T01331   alpha     NR2B1.     musculus s          ?T01331         <T05236>     fold more      lung,
                                                                               member
                                                                               of the
                                                                               steroid
                                                                               hormone
                                                                               receptor
                                                                               superfamil
                                                                               y [3]
                                                                               binds to
                                                                               regulatory
                                                                               element
                                                                               of major
                                                                               histocomp
                  H2RIIBP,                                                     atibility
                  retinoid X                       http://local                class I
                  receptor                         host/cgi-                   genes
                  beta,                            bin/biobas                  and to the
                  RXR-                             e/transfac/                 ER
                  beta,      human,                7.4/bin/get                 response
                  RXRB,      Homo       vertebrate TFProf.cgi                  element
T01334   RXR-beta NR2B2.     sapiens    s          ?T01334                     [3]            NULL
                                                                    two
                                                                    mRNA-
                                                                    species
                                                                    exist (2.7
                  retinoid X                                        kb and
                  receptor                                          3.0 kb)                  (adult:)
                  beta,                                             which                    high
                  RXR-                                              seem to                  levels in
                  beta,                             http://local    be                       adrenal,
                  NR2B2,                            host/cgi-       expressed                brain,
                  nuclear                           bin/biobas       to                      heart,
                  receptor     rat,                 e/transfac/     comparabl                kidney,
                  co-          Rattus               7.4/bin/get     e levels in              lung,
                  regulator    norvegicu vertebrate TFProf.cgi      the same                 muscle,
T01349   RXR-beta 1.           s         s          ?T01349         tissues [2] activator    spleen [2]
                                                                                provides
                                                                                gene
                                                                                regulation
                                                                                by
                                                                                steroids
                                                                                and
                                                                                xenobiotic
                                                                                s
                                                                                regulates
                                                                                both
                                                                                CYP2B
                                                                                and
                                                                                CYP3A
                                                                                cytochrom
                                                                                e genes
                                                                                in a
                                                                                complex
                                                                                interplay
                                                                    heterodim with
                                                                    er, for     CAR:RXR
                                                                    individual [1] is
                                                                    polypeptid able to
                                                                    es see      bind DNA
                                                                    human       response
                                                                    SXR         elements
                                                     http://local   <T04610> of
                                                     host/cgi-       and        different
                                                     bin/biobas     human       structure:
                                                     e/transfac/    RXR-        ER6 [2],
                               human,                7.4/bin/get    alpha       DR4 [1],
         SXR:RXR               Homo       vertebrate TFProf.cgi     <T01345> DR3 [1] in
T05670   -alpha                sapiens    s          ?T05670        .           several      NULL
                                                       transcripti
                                                       onal
                                                       inhibitor
                                                       [1] BMP-4
                                                       and
                                                       SMAD-1
                                                       <T04432>
                                                        activate
                                                       Xvent-1
                                                       expressio
                                                       n which
                                                       mediates
                                                       supressio
                                                       n of
                                                       FOXA4b
                                                       (XFD-1 )
                                                       <T01830>
                                        http://local    and its
                                        host/cgi-      restricted
                                        bin/biobas     expressio
                   clawed               e/transfac/    n to the
                   frog,                7.4/bin/get    Speman
                   Xenopus   vertebrate TFProf.cgi     organizer
T04665   Xvent-1   laevis    s          ?T04665        [1]         NULL
                                                                       repressor
                                                                       [2] the
                                                                       lower
                                                                       molecular
                                                                       weight
                                                                       population
                                                                        (180-190
                                                                       kDa) is
                                                                       predomin
                                                                       antly
                                                                       found in
                                                                       embryonic
                                                                        tissues,
                                                                       enhanced
                                                                       in
                                                                       committed

                                                                       myoblasts
                                                         CloxA is       and
                                                         most          chondrocy
                                                         likely an     tes [2] the
                                                         alternative   higher
                                                          splice       molecular
                                                         product       weight
                                                         of CDP        population
                                                         [2]            is
                                          http://local   human         prevalent
                                          host/cgi-      CDP(1-        in adult
                                          bin/biobas     878)/dog      and
                                          e/transfac/    Clox(879-     terminally
                       dog,               7.4/bin/get    1505)         differentiat
                CDP,   Canis   vertebrate TFProf.cgi     chimera       ed
T01485   Clox   Cux.   canis   s          ?T01485        [1]           tissues [2] NULL
                                                              data from     mediates
                                                              crystal       gene
                                                              structure,    induction
                                                              CD, NMR       /repressio
                                                              of the        n by
                                                              DBD           glucocorti
                                                              available     coids via
                                                              [11] [6]      direct
                                                              native        binding to
                                                              folding of    DNA
                                                              the DBD       glucocorti
                                                              to full       coid
                                                              alpha-        response
                                                              helix         elements
                                                              content       [22] [12]
                                                              requires      ligand
                                                              zinc ions     binding
                                                              [33] DNA-     leads to
                                                              binding to    dissociatio
                                                              a GRE         n from
                                                              half-site     hsp90
                                                              is            and
                                                              suppresse     allows
                                                              d by the      nuclear
                                                              A/B           translocati
                                                              region        on [5] GR
                                              http://local    first zinc    can act
                                              host/cgi-       finger        through
              glucocorti                      bin/biobas      binds         composite
              coid       rat,                 e/transfac/     specificall    elements
              receptor, Rattus                7.4/bin/get     y to GRE,     where it
              GCR,       norvegicu vertebrate TFProf.cgi      the           cooperate
T00333   GR   NR3C1.     s         s          ?T00333         second        s with      NULL


                                               http://local
                                               host/cgi-
              glucocorti                       bin/biobas
              coid                             e/transfac/
              receptor, chick,                 7.4/bin/get
              GR,        Gallus     vertebrate TFProf.cgi
T00334   GR   NR3C1.     gallus     s          ?T00334                                NULL
                                                                the first
                                                                zinc
                                                                finger of
                                                                the DBD
                                                                binds
                                                                specificall
                                                                y to the
                                                                GRE, the
                                                                second
                                                                enhances
                                                                the
                                                                affinity [9]
                                                                essential
                                                                for
                                                                GRE/ERE

                                                                discrimina
                                                                tion:
                                                                knuckle
                                                                of the 1st
                                                                zinc
                                                                finger
                                                                (GS vs.
                                                                EG)
                                                                ligand-
                                                                binding
                                             http://local       domain
                                             host/cgi-          (LBD)
              glucocorti                     bin/biobas         contains
              coid                           e/transfac/        a long
              receptor, mouse,               7.4/bin/get        helix, H9,
              GR,        Mus      vertebrate TFProf.cgi         with 30
T00335   GR   NR3C1.     musculus s          ?T00335            residues,      NULL


                                                 http://local
                                                 host/cgi-
              glucocorti                         bin/biobas
              coid                               e/transfac/
              receptor,                          7.4/bin/get
              GR,        cat, Felis   vertebrate TFProf.cgi
T00336   GR   NR3C1.     catus        s          ?T00336                       NULL
                                                                   2 splice      activator
                                                                   variants      or
                                                                   alpha         repressor
                                                                   <T00337>      in
                                                                    and beta     response
                                                                   <T01920>      to
                                                                    (742         glucocorti
                                                                   AA),          coid
                                                                   differing     hormones
                                                                   in their C-    [17]
                                                                   termini       binds
                                                                   [24] the      hormone,
                                                                   first zinc    translocat
                                                                   finger        es into
                                                                   binds         the
                                                                   specificall   nucleus,
                                                                   y to the      and
                                                                   GRE, the      activates
                                                                   second        transcripti
                                                                   enhances      on of
                                                                   the           hormone-
                                                                   affinity      sensitive
                                                                   [14]          gene in
                                                                   AGRND         contrast
                                                                   within the    to beta
                                                                   second        isoform
                                                    http://local   finger        <T01920>
                  glucocorti                        host/cgi-      mediates       which
                  coid                              bin/biobas     homodime      does not
                  receptor,                         e/transfac/    rization      activate
                  GR,        human,                 7.4/bin/get    and           known
                  NR3C1,     Homo        vertebrate TFProf.cgi     contribute    hormone-
T00337   GR-alpha GR alpha. sapiens      s          ?T00337        s to the      sensitive NULL


                  androgen                      http://local
                  receptor,                     host/cgi-
                  AR,                           bin/biobas
                  NR3C4,                        e/transfac/
                  dihydrotes mouse,             7.4/bin/get
                  tosterone Mus      vertebrate TFProf.cgi
T00041   AR       receptor. musculus s          ?T00041                                   NULL


                                                   http://local
                  androgen                         host/cgi-
                  receptor,                        bin/biobas
                  NR3C4,       baboon,             e/transfac/
                  dihydrotes   Papio               7.4/bin/get
                  tosterone    hamadrya vertebrate TFProf.cgi
T04652   AR       receptor.    s        s          ?T04652                                NULL
                                                    http://local
                androgen                            host/cgi-
                receptor,                           bin/biobas
                NR3C4,        Chimpanz              e/transfac/
                dihydrotes    ee, Pan               7.4/bin/get
                tosterone     troglodyte vertebrate TFProf.cgi
T04653   AR     receptor.     s          s          ?T04653                                 NULL


                                                     http://local
                androgen                             host/cgi-
                receptor,                            bin/biobas
                NR3C4,        macaque,               e/transfac/
                dihydrotes    Macaca                 7.4/bin/get
                tosterone     fasciculari vertebrate TFProf.cgi
T04654   AR     receptor.     s           s          ?T04654                                NULL


                                                    http://local
                androgen                            host/cgi-
                receptor,                           bin/biobas
                NR3C4,        lemur,                e/transfac/
                dihydrotes    eulemur               7.4/bin/get
                tosterone     fulvus     vertebrate TFProf.cgi
T04655   AR     receptor.     collaris   s          ?T04655                                 NULL


                                                                    regions A
                                                                    and C are     activator
                                                                    acidic,       of pol II
                                                                    region B      and pol III
                Se-Cys                              http://local    is basic      promoters
                tRNA                                host/cgi-       [2]            of
                gene                                bin/biobas      significant   several
                transcripti   clawed                e/transfac/      similarity   small
                on            frog,                 7.4/bin/get     with          RNA
                activating    Xenopus    vertebrate TFProf.cgi      human         genes [2]
T02247   Staf   factor.       laevis     s          ?T02247         ZNF76 [2]     [1]         NULL
                                                                 putatively
                                                                 an
                                                                 unusual
                                                                 member
                                                                 of the
                                                                 bZIP
                                                                 family of
                                                                 transcripti
                                                                 on factors
                                                                 strongly
                                                                 homologo
                                                                 us protein
                                                                 sequence
                                                                 and DNA
                                                                 recognitio
                                                                 n site to
                                                                 those of      suggested
                                                                 the            to
                                                                 factors       modulate
                                                                 P3A2 and      transcripti
                                                                 ewg [1],      on of
                                                                 and           metabolic
                                                                 therefore     genes
                                                                 also          important
                 alpha-                                          assumed       for cell
                 PAL,                                            to            growth [1]
                 alpha-                           http://local   constitute    and of
                 palindrom                        host/cgi-      an own        genes
                 e-binding                        bin/biobas     class of      encoding
                 protein,                         e/transfac/    transcripti   respiratory
                 nuclear     human,               7.4/bin/get    on factors     chain
                 respiratory Homo      vertebrate TFProf.cgi     with them     subunits
T00673   NRF-1    factor 1. sapiens    s          ?T00673        [2] the       [6] [3]     NULL


                                                  http://local                 activator,
                                                  host/cgi-                    regulator
                                                  bin/biobas                   of
                 NRF-1,      monkey,              e/transfac/                  nuclear-
                 nuclear     Cercopith            7.4/bin/get                  encoded
                 respiratory ecus      vertebrate TFProf.cgi                   respiratory
T01197   NRF-1    factor 1. aethiops s            ?T01197                       genes      NULL
                                                                activator,
                                                                stimulatin
                                                                g cells
                                                                proliferatio
                                                                n of
                                                                somatotro
                                                                phs,
                                                                lactotroph
                                                                s, and
                                                                thyrothrop
                                                                hs [2]
                                                                naturally
                                                                occurring
                                                                A158P
                                                                mutant
                                                                within
                                                                helix 1 of
                                                                POU2
                                                                has lost
                                                                gene
                                                                activation
                                                                capability,
                  Pit-1,                                        but still
                  GHF-1,                                        stimulates
                  Pit-1b,
                  pituitary-                                    proliferatio
                  specific                       http://local   n causing
                  positive                       host/cgi-      hypopituit
                  transcripti                    bin/biobas     arism in
                  on factor                      e/transfac/    homozygo
                  1, growth human,               7.4/bin/get    us
                  hormone Homo        vertebrate TFProf.cgi     individuals pituitary
T00325   POU1F1   factor 1. sapiens   s          ?T00325         [2]         [2]
                                                               activator,
                                                               also
                                                               responsibl
                                                               e for
                                                               establish
                                                               ment and
                                                               maintenan
                                                               ce of the
                                                               differentiat
                                                               ed
                                                               phenotype
                                                                of
                                                               somatotro
                                                               phs and
                                                               for
                                                               proliferatio
                                                               n of these
                                                               cells [4]
                                                               Pit-1
                                                               appearan
                                                               ce in
                                                               somatotro
                  Pit-1,                                       phs
                  GHF-1,                                       coincides
                  Pit-1b,                                      with
                  pituitary-                                   growth
                  specific                      http://local   hormone
                  positive                      host/cgi-      expressio
                  transcripti                   bin/biobas     n [6]
                  on factor                     e/transfac/    triggered
                  1, growth mouse,              7.4/bin/get    by cAMP
                  hormone Mus        vertebrate TFProf.cgi     to           pituitary
T01172   POU1F1   factor 1. musculus s          ?T01172        activate     gland
                                                                alternativetissue-
                                                                 splicing  specific
                                                                gives rise activator
                                                                to a 291   [27] [24]
                                                                AA         although
                                                                protein    binding to
                                                                which is   POU1F1
                                                                the major  sites like
                                                                form       POU1F1b
                                                                POU1F1a    , it trans-
                                                                 makes     activates
                                                                approxima  the
                                                                tely 1/7 ofgrowth
                                                                all        hormone
                                                                POU1F1     (GH)
                                                                mRNA in    gene, but
                                                                pituitary  not the
                                                                cells [8]  Prl and
                                                                [6]        GHF1
                                                                alternativepromoters
                                                                            (in
                                                               translation contrast
                                                                initiation to GHF-
                                                               gives rise 1) due to      lactotroph
                                                               to          the 26 AA     s,
                                                               another     insertion     somatotro
                                                  http://local product     [6]           phs and
                 GHF-2,                           host/cgi- of 31 kDa transcripti        thyrotroph
                 LSF-1,                           bin/biobas [12] both on of the         s of
                 Pit-1,      rat,                 e/transfac/ POUs         pit-1 gene    anterior
                 PUF-1,      Rattus               7.4/bin/get and          is            pituitary
                 PUF-I, Pit- norvegicu vertebrate TFProf.cgi POUh          triggered     gland [27]
T00691   POU1F1a 1a.         s         s          ?T00691 contact          by            [23] [20]
                                                            alternative tissue-
                                                             splicing   specific
                                                            gives rise  activator
                                                            to a 26     [25] [22]
                                                            AA          activates
                                                            insertion   the genes
                                                            after       for
                                                            position    growth
                                                            47          hormone
                                                            leading to  (GH),
                                                            an altered  prolactin
                                                            trans-      (Prl) and
                                                            activation  its own
                                                            domain in   (GHF1)
                                                            Pit-        promoter
                                                            1a/GHF-2    [5]
                                                            Pit-1b is   transcripti
                                                            the         on of the
                                                            predomin    pit-1 gene
                                                            ant form    is
                                                            [7] [5]     triggered
                                                            alternative by
                                                                        environme
                                                            translation ntal          lactotroph
                                                             initiation stimuli       s,
                                                            gives rise that           somatotro
                                               http://local to          enhance       phs and
                                               host/cgi- another        intracellul   thyrotroph
                                               bin/biobas product       ar cAMP       s of
                          rat,                 e/transfac/ of 31 kDa concentrat       anterior
                 LSF-1,   Rattus               7.4/bin/get [11] both ions [20]        pituitary
                 PUF-1,   norvegicu vertebrate TFProf.cgi POUs          autoregula    gland [25]
T01516   POU1F1b GHF-1.   s         s          ?T01516 and              tion          [21] [18]
                                                            detectable
                                                             as 6S
                                                            and 9S
                                                            form 95
                                                            kDa:
                                                            ligand-
                                                            binding
                                                            subunit
                                                            Stokes
                                                            radius:
                                                            7.1 nm
                                                            [22] [21]
                                                            dissociatio
                                                            n into
                                                            subunits
                                                            upon
                                                            prolonged
                                                            treatment
                                                            with 0.4      activator,
                                                            M KCl         binds to
                                                            sedimenti     xenobiotic
                                                            ng with        response
               AhR, Ah                                      4.9-5.6 S     element
               receptor,                                    [22]          [19] [20]
               dioxin                                       pI(calc.) =   [15] DNA-
               receptor,                                    5.98 [10],    binding
               XRE-                          http://local   pI(exp.) =    can be
               binding                       host/cgi-      5.2-5.7       abolished
               factor,                       bin/biobas     [14] in       by
               aryl                          e/transfac/    heterodim     phosphata
               hydrocarb mouse,              7.4/bin/get    eric          se
               on        Mus      vertebrate TFProf.cgi     complexe      treatment
T00018   AhR   receptor. musculus s          ?T00018        s with        [11]       NULL
                                                               95 kDa:
                                                               ligand-
                                                               binding
                                                               subunit
                                                               Stokes
                                                               radius:
                                                               7.0 nm
                                                               dissociatio
                                                               n into
                                                               subunits      activator,
                                                               upon          binds to
                                                               treatment     xenobiotic
                                                               with 0.4       response
                                                               M KCl         element
                                                               sedimenti     [7] quickly
                                                               ng with       up-
                                                               4.9-5.6 S     regulated
                                                               [13]          by aryl
                                                               faster        hydrocarb
                                                               dissociatio   ons (e.g.
                                                               n than        TCDD)
                                                               murine        within 30
               AhR, Ah                                         complex       min,
               receptor,                                       [13]          down-
               dioxin                                          interacts     regulated
               receptor,                                       with          requiring
               XRE-                             http://local   hsp90 [9]     an            highest
               binding                          host/cgi-      [8] DNA-      additional,   levels in
               factor,                          bin/biobas     binding of     labile       liver,
               aryl        rat,                 e/transfac/    the           factor        lower in
               hydrocarb   Rattus               7.4/bin/get    heterodim     over the      thymus,
               on          norvegicu vertebrate TFProf.cgi     er with       subseque      kidney,
T00019   AhR   receptor.   s         s          ?T00019        Arnt is       nt 2 h [1]    lung [2]
                                                                      binds to
                                                                      xenobiotic
                                                                       response
                                                                      element
                                                                      dioxin-
                                                                      induced
                                                                      DNA
                                                                      binding
                                                                      and gene
                                                                      induction
                                                                      by AhR is
                                                                      down-
                                                                      regulated
                                                                      by cobalt
                                                                      ions (or
                                                                      hypoxia)
                                                           heterodim through
                                                           erization activation
                                                           with Arnt of HIF-
                                              http://local required 1alpha
               AhR, Ah                        host/cgi- for DNA- competing
               receptor,                      bin/biobas binding       for the
               aryl                           e/transfac/ [9] [8],    dimerizati
               hydrocarb human,               7.4/bin/get interaction on
               on        Homo      vertebrate TFProf.cgi with         partner
T01795   AhR   receptor. sapiens   s          ?T01795 hsp90 [10] Arnt [5] [4] NULL
                                                              binds to a
                                                              xenobiotic
                                                                response
                                                              element
                                                              strongly
                                                              activated
                                                              by TCDD
                                                              and by
                                                              staurospo
                                                              rin as
                                                              ligands
                                                              [1]
                                                              induction
                                                              is not
                                                              inhibited
                                                              by PKC
                                                              inhibitors
                                                              H7 or
                                                              calphostin
                                                              ,
                                                              therefore
                                               http://local   PKC
               AhR, Ah                         host/cgi-      seems
               receptor,                       bin/biobas     not to be
               aryl                            e/transfac/    involved
               hydrocarb guinea                7.4/bin/get    in AhR     (TCDD-
               on        pig, Cavia vertebrate TFProf.cgi     induction induced
T02270   AhR   receptor. sp.        s          ?T02270        [1]        liver)
                                                               there is a   involved
                                                               splice       in and
                                                               variant of   required
                                                               774 AA       for Ah
                                                               <T01796>     receptor
                                                                [9] the     binding to
                                                               PAS          XREs [9]
                                                               domain       [8] no
                                                               reveals      ligand
                                                               some         (dioxin)
                                                               homology     binding
                                                               to           strong
                                                               Drosophil    constitutiv
                                                               a            e
                                                               melanoga     activator
                                                               ster Per     [7]
                                                               and Sim      relative
                                                               [5] in       contributio
                                                               heterodim    n of Arnt
                                                               eric         and AhR
                                                               complexe     to overall
                hypoxia-                                       s with       activation
                inducible                                      either       by the
                factor                                         AhR or       AhR/Arnt
                1beta,                                         Sim, Arnt    complex
                aryl                                           recognize    depend
                hydrocarb                       http://local   s the 3 -    on cell
                on                              host/cgi-      half-site    type and
                receptor                        bin/biobas     sequence     promoter
                nuclear                         e/transfac/    GTG [5]      context
                translocat human,               7.4/bin/get    both the     [7] HIF-1
                or, HIF-   Homo      vertebrate TFProf.cgi     HLH and      (HIF-
T01346   Arnt   1beta.     sapiens   s          ?T01346        the PAS      1alpha/Ar NULL
                                                                 the basic
                                                                 region
                                                                 contacts
                                                                 DNA, the
                                                                 HLH
                                                                 domain
                                                                 mediates
                                                                 dimerizati
                                                                 on [4] the
                                                                 PAS
                                                                 domain
                                                                 reveals
                                                                 some
                                                                 homology
                                                                 to
                                                                 Drosophil
                                                                 a
                                                                 melanoga
                                                                 ster Per
                                                                 and Sim
                                                                 [1] it
                hypoxia-                                         augments
                inducible                                        hetero-,
                factor                                           but not
                1beta,                                           homodime
                aryl                                             rization
                hydrocarb                      http://local      and is         promotes
                on                             host/cgi-         essential      release of
                receptor                       bin/biobas        for Arnt       ligand-
                nuclear                        e/transfac/       function       complexe
                translocat mouse,              7.4/bin/get       in vivo [4]    d AhR
                or, HIF-   Mus      vertebrate TFProf.cgi        [2] Arnt       from
T01797   Arnt   1beta.     musculus s          ?T01797           does not       hsp90 [3] (liver)

                                                                 there may
                                                                 be a
                                                                 splice         coordinate
                                                                 variant [2]
                                                                 band           expressio
                                                                 doublet in     n with
                hypoxia-                                         SDS            AhR in
                inducible                                        PAGE [3]       placenta
                factor                                           significantl   at a
                1beta,                                           y              relatively
                aryl                                             increases      low level
                hydrocarb                         http://local   DNA-           [2] here,
                on                                host/cgi-      binding        the splice
                receptor                          bin/biobas     by AhR         variant is
                nuclear      rat,                 e/transfac/    by             predomin
                translocat   Rattus               7.4/bin/get    heterodim      antly
                or, HIF-     norvegicu vertebrate TFProf.cgi     erization      expressed
T01798   Arnt   1beta.       s         s          ?T01798        [3]             [2]       (liver)
                                                                                   (embryo:)
                                                                                   visceral
                                                                                   arches,
                                                                                   gut/intesti
                                                                                   nes,
                                                                                   kidney,
                                                             phosphory  involved   lung,
                                                             lation the in control thymus,
                                                             basic      of         CNS,
                                                             region                PNS;
                                                                        proliferatio
                                                             determine  n and      very low
                                                 http://locals its DNA-            levels in
                                                                        differentiat
                                                 host/cgi-   binding    ion        limbs
                                                 bin/biobas  specificityaberrant   (late fetal
                                                 e/transfac/ which is   expressio  stages),
                             mouse,              7.4/bin/get similar to n may      somites
                             Mus      vertebrate TFProf.cgi  that of c- cause      and skin,
T01445   N-Myc               musculus s          ?T01445     Myc [2] [1]neoplasm
                                                                        activator  heart [3]
                                                                        [1] may
                                                                        function
                                                                        as a
                                                                        repressor
                                                                        [2] HIF-1
                                                                        mediates
                                                                        gene
                                                                        responses
                                                                         to
                                                                        lowered
                                                                        oxygen
                                                                        levels
                                                                        (hypoxia,
                                                                        O2
                                                                        demand
                                                                        exceeds
                                                                        supply)
                                                                        under
                                                                        which
                                                              HIF-1     state the
                                                              consists concentrat
                                                              of two    ion of HIF-
                                                              bHLH      1 is
                                                              subunits, increased
                                                              HIF-      [4] HIF-
                                                 http://local 1alpha    1alpha,
                                                 host/cgi- <T01610> but not
                                                 bin/biobas and HIF- HIF-
                                                 e/transfac/ 1beta      1beta,
                 hypoxia-    human,              7.4/bin/get (Arnt)     needs
                 inducible   Homo     vertebrate TFProf.cgi <T01346> hypoxia
T01609   HIF-1   factor 1.   sapiens  s          ?T01609 [4]            for          NULL
                                                                  HIF-1
                                                                  consists
                                                                  of two
                                                                  bHLH
                                                                  subunits,
                                                 http://local     HIF-
                                                 host/cgi-        1alpha
                                                 bin/biobas       <T04666>
                                                 e/transfac/       and HIF-
                 hypoxia-    mouse,              7.4/bin/get      1beta
                 inducible   Mus      vertebrate TFProf.cgi       (Arnt)
T04667   HIF-1   factor 1.   musculus s          ?T04667          <T01797>     NULL


                                                   http://local
                                                   host/cgi-      heterodim
                                                   bin/biobas     er of HIF-
                                                   e/transfac/    1alpha
                 hypoxia-    cattle,               7.4/bin/get    and HIF-
                 inducible   Bos        vertebrate TFProf.cgi     1beta
T05377   HIF-1   factor 1.   taurus     s          ?T05377        (=Arnt)      NULL


                                                                  heterodim
                                                  http://local    er of HIF-
                                                  host/cgi-       1alpha
                                                  bin/biobas      <T05461>
                             rat,                 e/transfac/      and HIF-
                 hypoxia-    Rattus               7.4/bin/get     1beta
                 inducible   norvegicu vertebrate TFProf.cgi      (Arnt)
T05404   HIF-1   factor 1.   s         s          ?T05404         <T01798>     NULL
                                                              isolated      proto-
                                                              bHLH-         oncogene
                                                              ZIP           involved
                                                              region:       in cell
                                                              mycPp         proliferatio
                                                              bHLH-         n control,
                                                              ZIP           may
                                                              domain        induce
                                                              interacts     apoptosis
                                                              with the      may be
                                                              C-            involved
                                                              terminal      in post-
                                                              part of       transcripti
                                                              AP-2 [17]     onal
                                                              pRb           regulation
                                                              related       of rRNA
                                                              protein       metabolis
                                                              p107          m [27]
                                                              forms a       Myc
                                                              specific      induces
                                                              complex       cyclin A
                                                              with the      and cyclin
                                                              N-            E
                                                              terminal      expressio
                                                              transactiv    n and
                                                              ation         leads to a
                                               http://local   domain of     growth
                                               host/cgi-      c-Myc in      factor-
                                               bin/biobas     vivo,         independe
                                               e/transfac/    binding       nt
                          human,               7.4/bin/get    causes a      associatio
                          Homo      vertebrate TFProf.cgi     significant   n of cyclin
T00140   c-Myc   c-Myc.   sapiens   s          ?T00140         inhibition   A with       NULL
                                                             role in
                                                             cell
                                                             proliferatio
                                                             n and
                                                             differentiat
                                                             ion of
                                                             chondrocy
                                                             tes [3] c-
                                                             myc gene
                                                             is
                                                             involved
                                                             in the
                                                             developm
                                                             ent of B-
                                                             cell
                                                             lymphoma
                                                             s [13] [11]
                                                             [12]
                                                             phosphory
                                                             lation
                                                             may
                                                             enhance
                                                             trans-
                                              http://local   activation
                                              host/cgi-      and may        differentiat
                                              bin/biobas     down-          ing and
                                              e/transfac/    regulate       proliferatin
                          chick,              7.4/bin/get    transform      g
                          Gallus   vertebrate TFProf.cgi     ation          chondrocy
T00141   c-Myc   c-Myc.   gallus   s          ?T00141        activity [1]   tes [3]
                                                                            participate
                                                                            s in the
                                                              Myc proto-    regulation
                                                              oncogene      of gene
                                                              protein [6]   transcripti
                                                              efficient     on of
                                                              DNA           growth-
                                                              binding       related
                                                              requires      genes [6]
                                                              dimerizati    role in
                                                              on with       cell
                                                              another       proliferatio
                                                              bHLH          n and
                                                              protein       differentiat
                                                              binds         ion of
                                                              DNA as        chondrocy
                                                              an            tes [4]
                                                              heterodim     induces
                                                              er with       apoptosis
                                                              Max           in the
                                                              binds         absence
                                                              DNA both      of certain
                                                              in a non-     growth
                                                              specific      factors [3]
                                                              manner        positively
                                                              and also      regulates
                                               http://local   specificall   the genes
                                               host/cgi-      y to          for            differentiat
                                               bin/biobas     recognize     translation    ing and
                          rat,                 e/transfac/    s the core     initiation    proliferatin
                          Rattus               7.4/bin/get    sequence      factors        g
                          norvegicu vertebrate TFProf.cgi     CAC(GA)       eIF-4E         chondrocy
T00142   c-Myc   c-Myc.   s         s          ?T00142        TG [6]        and -          tes [4]
                                                             c-myc
                                                             proto-
                                                             oncogene
                                                             nuclear
                                                             protein
                                                             glycoprote
                                                             in           transcripti
                                                             efficient    onal
                                                             DNA          regulator
                                                             binding      activator
                                                             requires     [12]
                                                             dimerizati   forced
                                                             on with      overexpre
                                                             another      ssion of c-
                                                             bHLH         Myc in
                                                             protein      lens fiber
                                              http://local   binds        cells
                                              host/cgi-      DNA as       causes
                                              bin/biobas     an           inappropri
                                              e/transfac/    heterodim    ate cell
                          mouse,              7.4/bin/get    er with      cycle
                          Mus      vertebrate TFProf.cgi     Max [12]     progressio
T00143   c-Myc   c-Myc.   musculus s          ?T00143        [13]         n [3]       NULL
                                                             several       enhances
                                                             splice        c-Myc
                                                             variants      DNA-
                                                             <T00489>      binding in
                                                             ,             high
                                                             <T01567>      concentrat
                                                               detected    ions:
                                                             Max           homodime
                                                             homodime      rs
                                                             rs and        suppress
                                                             Myc/Max       c-Myc
                                                             heterodim     activities
                                                             ers           by
                                                             exhibit       competitio
                                                             different     n [13] [16]
                                                             preferenc     [6] after
                                                             es for the    CKII
                                                             trinucleoti   phosphory
                                                             des           lation,
                                                             flanking      increases
                                                             the core      in on- and
                                                             sequence      off-rates
                                                             (CACGTG       of DNA-
                                                             ) [5]         binding of
                                                             Max1 and      homo-
                                                             Max2          and
                                              http://local   also differ   heterodim
                                              host/cgi-      slightly in   ers have
                                              bin/biobas     their DNA-    been
                                              e/transfac/    binding       found [8]
                Max, Myn human,               7.4/bin/get    specificity   preferenti
                (mouse), Homo      vertebrate TFProf.cgi     [5] [12]      ally
T00489   Max1   p21.     sapiens   s          ?T00489        heterodim     complexe NULL
                                                              solution
                                                              of the
                                                              crystal
                                                              structure
                                                              revealed
                                                              that the
                                                              HLH            enhances
                                                              motifs         c-Myc
                                                              form a         DNA-
                                                              four-helix-    binding,
                                                              bundle         perturbati
                                                              with all       on of
                                                              helices in     homodime
                                                              parallel       r-binding
                                                              orientation    after CKII
                                                               [5] helix     phosphory
                                                              2 is           lation, but
                                                              prolonged      not of
                                                              by the         Myc/Max-
                                                              alpha-         heterodim     newborn:
                                                              helically      er [6] in     intestine,
                                                              folded         complexe      weak in
                                                              leucine        s with        brain,
                                                              zipper         either        liver,
                                                              heterodim      Mxi1 or       lung;
                                                              ers with c-    Mad, it       adult:
                                               http://local   Myc or         represses     very
                                               host/cgi-      Mad have       c-Myc or      strong in
                 Myn, Myc-                     bin/biobas     higher         N-Myc         intestine,
                 binding                       e/transfac/    DNA-           effects [4]   weak in
                 novel     mouse,              7.4/bin/get    binding        murine        brain,
                 HLH/LZ    Mus      vertebrate TFProf.cgi     affinity [9]   homolog       kidney,
T00523   Max     protein.  musculus s          ?T00523        the            of MAX [9]    lung [3]

                                                                        activates
                                                                        several
                                                                        intestine-
                                                                        specific
                                                                        promoters
                                                                         [4] [3]
                                                                        activates
                                                                        liver-
                                                                        specific
                                                                        promoters
                                                                         [6] [1]
                                                              nuclear   previously
                                                 http://local activity,  known
                 AF-1,                           host/cgi- may be       as AF-1
                 HNF4,                           bin/biobas composed binding to
                 hepatocyt                       e/transfac/ of HNF- apolipopro
                 e nuclear human,                7.4/bin/get 4alpha,    tein
                 factor 4, Homo       vertebrate TFProf.cgi HNF-        promoters
T02758   HNF-4   NR2A1.    sapiens    s          ?T02758 4gamma. [6]               NULL
                                                             two
                                                             isoforms
                                                             (at least
                                                             for
                                                             human
                                                             and
                                                             mouse)
                                                             encoded
                                                             by two
                                                             different
                                                             genes
                                                             are
                                                             known:
                                                             HNF-
                                                             4alpha
                                                             and HNF-
                                                             4gamma
                                                             for HNF-4
                                                             alpha
                                                             <T05288>
                                                               two
                                                             splice
                                                             variants
                                                             are
                                                             known:
                                              http://local   HNF-
                                              host/cgi-      4alpha1     activator
                                              bin/biobas     <T00372>    activates
                         rat,                 e/transfac/    , HNF-      genes in
                         Rattus               7.4/bin/get    4alpha2     liver,       (rat liver
                         norvegicu vertebrate TFProf.cgi     <T02422>    kidney,      nuclear
T05017   HNF-4   AF-1.   s         s          ?T05017        .           intestine.   extracts)


                                              http://local
                                              host/cgi-
                                              bin/biobas                 activator
                         chipmunk,            e/transfac/                of
                          Tamias              7.4/bin/get                hibernatio
                         asiaticus vertebrate TFProf.cgi                 n-specific
T05294   HNF-4   HNF4.   (sibiricus) s        ?T05294                    gene [1] liver
                                                                forms         activator
                                                                homodime      of genes
                                                                rs            involved
                                                                alternative   in
                                                                 splice       glucose
                                                                variants      transport
                                                                of HNF-       and
                                                                4alpha:       metabolis
                                                                HNF-          m:
                                                                4alpha1       glucose
                                                                <T02421>      transporte
                                                                , HNF-        r 2,
                                                                4alpha2       aldolase
                                                                <T00373>      B,
                                                                , HNF-        glyceralde
                                                                4alpha3       hyde-3-
                                                                <T02428>      phosphate
                                                                 and HNF-
                                                                4alpha4       dehydroge
                                                                <T02425>      nase and
                                                                 an           liver
                                                                additional    pyruvate
                                                                exon 1C       kinase [6]
                                                                has been      controls      pancreas,
                                                                described     the           kidney,
                                                                [5]           expressio     liver,
                  HNF4,                          http://local   interacts     n of the      small
                  HNF-4,                         host/cgi-      with co-      liver         intestine,
                  hepatocyt                      bin/biobas     activator     specific      colon,
                  e nuclear                      e/transfac/    PGC-1         transcripti   testis
                  factor 4, human,               7.4/bin/get    through       on factor     (barely
         HNF-     HNF-4A, Homo        vertebrate TFProf.cgi     AF-2          HNF-1A        detectable
T03828   4alpha   NR2A1.    sapiens   s          ?T03828        domain [1]    <T00368>      ) [9]


                                                                forms
                                                                homodime
                                                                rs at least
                                                                3 splice
                                                                variants
                                                                are
                                                                known:
                                                                HNF-
                                                                4alpha1
                                                http://local    <T02424>
                                                host/cgi-       , HNF-
                                                bin/biobas      4alpha2
                  AF-1,                         e/transfac/     <T02423>      activator
                  HNF4,     mouse,              7.4/bin/get     , HNF-        of liver-
         HNF-     NR2A1,    Mus      vertebrate TFProf.cgi      4alpha7       specific
T05287   4alpha   HNF4A.    musculus s          ?T05287         <T02427>      genes [1] NULL
                                                                  forms
                                                                  homodime
                                                                  rs            activator
                                                                  exclusivel    of liver-
                                                                  y, does       specific
                                                                  not form      genes
                                                                  heterodim     first,
                                                                  ers with      identified
                                                                  RARs,         as a
                                                                  RXR-          nuclear
                                                                  alpha,        activity
                                                                  ARP-1,        AF-1
                                                                  TR-alpha,     activating
                                                                  VDR [4]       apolipopro
                                                                  at least      tein
                                                                  two splice    genes [8]
                                                                  variants      [6] [7] can
                                                                  are           functionall
                                                                  known:        y
                                                                  HNF-          cooperate
                                                                  4alpha1        with
                                                                  <T00372>      SMAD-
                                                                  , HNF-        3/SMAD-
                                                                  4alpha2       4 and
                                                                  <T02422>      thus
                                                                   located      participate
                                                  http://local    exclusivel     in
                                                  host/cgi-       y in the      TGFbeta
                                                  bin/biobas      nucleus       induction
                             rat,                 e/transfac/     [4]           of the
                             Rattus               7.4/bin/get     nuclear       ApoC3
         HNF-                norvegicu vertebrate TFProf.cgi      localizatio   promoter
T05288   4alpha    AF-1.     s         s          ?T05288         n and         [2]         NULL

                                                                  the
                   HNF4,                                          originally
                   HNF-4,                                         published
                   hepatocyt                                      455-AA
                   e nuclear                                      sequence
                   factor 4,                       http://local   may lack
                   hepatocyt                       host/cgi-      an
                   e nuclear                       bin/biobas     authentic
                   factor                          e/transfac/    N-
                   4alpha1, human,                 7.4/bin/get    terminal
         HNF-      HNF-4A, Homo         vertebrate TFProf.cgi     9-AA
T02421   4alpha1   NR2A1.    sapiens    s          ?T02421        stretch [2]             NULL
                                                                            (embryoni
                                                                            c)
                                                                            visceral
                                                                            extraembr
                                                                            yonic
                                                                            endoderm
                                                                             (d 7-10
                                                                            pc), in the
                                                                            periphery
                                                                            of the
                                                                            liver (d
                                                                            11.5-16
                                                                            pc),
                                                                            meso-
                                                                            and
                                                                            metaneph
                                                                            ros of the
                                                                            kidney (d
                   HNF4,                                                    10.5-
                   HNF-4,                                                   birth) [4];
                   hepatocyt                                                (adult)
                   e nuclear                     http://local               kidney,
                   factor 4,                     host/cgi-                  liver,
                   hepatocyt                     bin/biobas                 stomach,
                   e nuclear                     e/transfac/                low in
                   factor    mouse,              7.4/bin/get                intestine
         HNF-      4alpha1, Mus       vertebrate TFProf.cgi                 [1], skin
T02424   4alpha1   NR2A1.    musculus s          ?T02424                    [4]
                                                                transcripti
                                                                onal
                                                                activator
                                                 http://local   may be
                                                 host/cgi-      antagoniz
                   hepatocyt                     bin/biobas     ed by
                   e nuclear rat,                e/transfac/    ARP-1
                   factor    Rattus              7.4/bin/get    and/or      liver,
         HNF-      4alpha2, norvegicu vertebrate TFProf.cgi     COUP-       kidney,
T02422   4alpha2   NR2A1.    s        s          ?T02422        TF [1]      intestine


                                                 http://local
                                                 host/cgi-
                   hepatocyt                     bin/biobas
                   e nuclear                     e/transfac/
                   factor    mouse,              7.4/bin/get
         HNF-      4alpha2, Mus       vertebrate TFProf.cgi
T02423   4alpha2   NR2A1.    musculus s          ?T02423                    NULL
                                                                  the
                                                                  published     activator,
                                                                  sequence      similar
                                                   http://local   may lack      trans-
                   hepatocyt                       host/cgi-      an            activation
                   e nuclear                       bin/biobas     additional    capability
                   factor                          e/transfac/    N-            as HNF-
                   4alpha3, human,                 7.4/bin/get    terminal      4alpha1
         HNF-      HNF-4C, Homo         vertebrate TFProf.cgi     9-AA          and -
T02428   4alpha3   NR2A1.    sapiens    s          ?T02428        stretch [2]   alpha2 [3] NULL


                                                   http://local
                                                   host/cgi-
                   hepatocyt                       bin/biobas
                   e nuclear                       e/transfac/
                   factor    human,                7.4/bin/get
         HNF-      4alpha4, Homo        vertebrate TFProf.cgi                   activator
T02425   4alpha4   NR2A1.    sapiens    s          ?T02425                      [1] NULL
                                                                                    dedifferen
                                                                                    tiated
                                                                                    hepatic
                                                                                    cells,
                                                                                    (adult:)
                                                                       activator, stomach,
                                                                       significantl liver,
                   hepatocyt                     http://local          y lower      intestine,
                   e nuclear                     host/cgi-             trans-       very low
                   factor                        bin/biobas            activation in
                   4alpha7,                      e/transfac/           than by      bladder,
                   NR2A1,    mouse,              7.4/bin/get incomplet HNF-         brain,
         HNF-      HNF-      Mus      vertebrate TFProf.cgi e C-       4alpha1      heart,
T02427   4alpha7   4alphaP2. musculus s          ?T02427 terminus [1]               ovary, [1]
                                                                 results
                                                                 from
                                                                 transcripti
                                                                 on from
                                                                 the
                                                                 alternative
                                                                  promoter
                                                                 P2 and
                                                                 splicing
                                                                 exon P2
                                                                 to exon 2
                                                                 removing
                                                                 a
                                                                 fragment
                                                                 of 50.205
                                                                 Kb from
                                                                 the
                                                                 human
                                                                 HNF-
                                                                 4alpha
                                                                 gene [1]
                                                                 for
                                                                 alternative
                                                                  splice
                                                                 variants
                                                                 see HNF-
                                                  http://local   4alpha1
                                                  host/cgi-      <T02421>
                                                  bin/biobas     , HNF-
                                                  e/transfac/    4alpha2
                             human,               7.4/bin/get    <T00373>
         HNF-      HNF-      Homo      vertebrate TFProf.cgi     , HNF-
T05285   4alpha7   4alphaP2. sapiens   s          ?T05285        4alpha3                   NULL

                                                                                           kidney,
                                                  http://local                             pancreas,
                   hepatocyt                      host/cgi-                                small
                   e nuclear                      bin/biobas                               intestine,
                   factor                         e/transfac/                              testis,
                   4gamma, human,                 7.4/bin/get                              very low
         HNF-      HNF4G, Homo         vertebrate TFProf.cgi                   activator   in colon
T02430   4gamma    NR2A2.    sapiens   s          ?T02430                      [3]         [3]
                                                                  cDNA
                                                                  clone
                                                                  (ORF of
                                                                  >218 AA)
                                                                  was
                                                                  supposed
                                                                  to be
                                                                  partial [4],
                                                                  but
                                                                  genomic
                                                                  clones
                                                                  suggest a
                                                                  protein of
                 C/EBPga                                          150 AA
                 mma,                           http://local      (16.4
                 GPE1-                          host/cgi-         kDa) [3]                     ubiquitous
                 BP,                            bin/biobas        no
                 Ig/EBP1,                       e/transfac/       heterodim      transcripti   (macroph
                 muEBP- mouse,                  7.4/bin/get       ers with       onal          ages,
         C/EBPga E, Ig/EBP- Mus      vertebrate TFProf.cgi        DBP [1]        activator     early B
T00216   mma     1.         musculus s          ?T00216           [4]            [6] [9]       cells) [2]

                                                                                 activator
                                                                  preferenti     [4]
                                                                  al             synergistic
                                                                  heterodim      ally
                                                                  erization      cooperate
                                                  http://local    with           s with NF-
                                                  host/cgi-       CREB-          kappaB,
                                                  bin/biobas      2/ATF-4,       presumabl
                             rat,                 e/transfac/     no             y by
                             Rattus               7.4/bin/get     heterodim      physical
         C/EBPga             norvegicu vertebrate TFProf.cgi      ers with       interaction ubiquitous
T02028   mma                 s         s          ?T02028         DBP [1]         [2]        [3]


                                                   http://local
                                                   host/cgi-
                 CCAAT/e                           bin/biobas
                 nhancer                           e/transfac/
                 binding  human,                   7.4/bin/get
         C/EBPga protein- Homo          vertebrate TFProf.cgi
T04884   mma     gamma. sapiens         s          ?T04884                                     NULL
                                                              the N-
                                                              terminal
                                                              part of
                                                              the
                                                              molecule
                                                              does not
                                                              exhibit
                                                              significant
                                                               homolgy
                                                              with other
                                                              members
                                                              of the NF-
                NF-E2-                                        E2 family
                related                                       [3] DNA-
                factor 2,                      http://local   binding
                nuclear                        host/cgi-      as
                factor,                        bin/biobas     heterodim
                erythroid                      e/transfac/    er with
                derived 2, human,              7.4/bin/get    small Maf
                like 2,    Homo     vertebrate TFProf.cgi     proteins
T01443   Nrf2   NFE2L2. sapiens     s          ?T01443        [1]           NULL
                                                                                    important     (embryoni
                                                                                    for           c:) (in
                                                                                    transcripti   situ:)
                                                                                    onal          expressed
                                                                      belongs       induction      at E7,
                                                                      to the        of            E11, E15,
                                                                      CNC           antioxidan    E17 [1];
                                                                      (Cap´n´col    t             E15.5 (in
                                                                      lar)          enzymes       situ):
                                                                      domain        and           highest
                                                                      containing    phase II      level in
                                                                                    drug          digestive
                                                                      subfamily     metabolizi    tract and
                                                                      of bZIP       ng            also high
                                                                      transriptio   enzymes       levels in
                                                                      n factors     through       liver,
                                                                      and has       ARE           lung,
                                                                      high          (antioxida    kidney
                                                                      sequence      nt            [1];
                     NF-E2                                            similarity    response      expressed
                     related                                          to            element/el     in central
                     factor 2,                                        subfamily     ectrophile    nervous
                     NFE2-                                            members       response      system
                     related                                          p45-          element)      (lateral
                     factor 2,                                        NFE2,         (compare      ventricle,
                     nuclear                                          NRF1,         to [3]) no    choroid
                     factor,                          http://local    and           detectable    plexus),
                     erythroid                        host/cgi-       NRF2 [1]        effect of   stomach,
                     derived 2,                       bin/biobas      forms         targeted      brown fat
                     like 2,                          e/transfac/     heterodim     disruption    tissue [1]
                     NFE2L2,      mouse,              7.4/bin/get     er with       of gene       (adult:)
                     NRF2,        Mus      vertebrate TFProf.cgi      MafK          function      heart,
T04938   Nrf2        NRF-2.       musculus s          ?T04938         <T05576>      (homozyg      spleen,
                     NFE2-
                     related
                     factor 2,                         http://local
                     nuclear                           host/cgi-
                     factor,                           bin/biobas
                     erythroid    rat,                 e/transfac/
                     derived 2,   Rattus               7.4/bin/get
                     like 2,      norvegicu vertebrate TFProf.cgi
T05668   Nrf2        NFE2L2.      s         s          ?T05668                                    NULL


                                                      http://local
                                                      host/cgi-       heterodim
                                                      bin/biobas      er of Nrf2
                                                      e/transfac/     <T04938>
                                  mouse,              7.4/bin/get     and
                                  Mus      vertebrate TFProf.cgi      MafK
T05576   Nrf2:MafK                musculus s          ?T05576         <T01435>                    NULL
                                                                     Nrf2
                                                                     shows
                                                                     DNA-
                                                     http://local    binding
                                                     host/cgi-       as
                                                     bin/biobas      heterodim
                                rat,                 e/transfac/     er with
                                Rattus               7.4/bin/get     MafK, but
                                norvegicu vertebrate TFProf.cgi      not alone
T05666   Nrf2:MafK              s         s          ?T05666         [1]                       NULL
                                                                     no PKA
                                                                     or PKC
                                                                     phosphory
                                                                     lation
                                                                     sites [4]
                                                                     in
                                                                     contrast
                                                                     to other
                                                                     ATF           repressor
                                                                     factors, it   [4] mRNA
                                                                     does not      decreases
                                                                     interact
                                                                     with p50      temporaril
                                                                     or p65        y after
                                                                     subunit of    raising
                                                                     NFkappa       the cAMP
                                                                     B [3]         concentrat
                                                                     interacts     ion, but
                                                                     with          increases
                                                                     latency-      with
                     ATF-4,                                          associate     enhanced
                     CREB-2,                                         d nuclear     calcium
                     TAXREB6                                         antigen       concentrat
                     7                                               (LANA         ion [6]
                     homolog,                                        <T04852>      interaction
                     YAVREB6                          http://local   ) of           with
                     7, TR67,                         host/cgi-      Kaposi s      LANA
                     C/ATF,                           bin/biobas     sarcoma-      <T04852>
                     activating                       e/transfac/    assoziate      inhibits
                     transcripti human,               7.4/bin/get    d             transactiv
                     on factor Homo        vertebrate TFProf.cgi     herpesviru    ation
T01303   ATF4        4.          sapiens   s          ?T01303        s [1]         ability [1] ubiquitous
                   ATF-4,
                   CREB-2,
                   TAXREB6
                   7
                   homolog,
                   YAVREB6                                        isoform
                   7, TR67,                        http://local   ATF (381
                   C/ATF,                          host/cgi-      AA)
                   mTR67,                          bin/biobas     <T02052>
                   activating                      e/transfac/     by           transcripti
                   transcripti mouse,              7.4/bin/get    alternative   onal
                   on factor Mus        vertebrate TFProf.cgi      initiation   activator
T04854   ATF4      4.          musculus s          ?T04854        site          [1]         NULL


                   ATF-4,
                   CREB-2,
                   TAXREB6
                   7
                   homolog,
                   YAVREB6
                   7, TR67,                        http://local   isoform
                   C/ATF,                          host/cgi-      ATF
                   mTR67,                          bin/biobas     <T04854>
                   activating                      e/transfac/     by           transcripti
                   transcripti mouse,              7.4/bin/get    alternative   onal
         ATF4      on factor Mus        vertebrate TFProf.cgi      initiation   activator
T02052   (381AA)   4.          musculus s          ?T02052        site          [1]         ubiquitous
                                                              DNA           potent
                                                              binding       activator
                                                              affinity of   when
                                                              the           bound in
                                                              monomer:      the right
                                                               KD = 1       context,
                                                              nM [24]       e. g. with
                                                              contacts      an
                                                              DNA from      adjacently
                                                              one side       binding
                                                              [24] and      TCF-2
                                                              induces a     [17]
                                                              bent of       activator,
                                                              about         possibly
                                                              117-130       by
                                                              degree        augmentin     pre-B
                                                              [21] [14]     g an          cells, T
                                                              widens        optimal       lymphocyt
                                                              and binds     chromatin     es [22];
                                                              the minor     architectur   during
                                                              groove of     e [21]        embryoge
                                                              DNA [21]      which         nesis:
                                                              [14] the L-   facilitates   neural
                                                              shape         other         crest,
                                                              HMG           factors to    mesencep
                                                              domain        assemble      halon,
                                               http://local   also          to a          tooth
                 LEF 1,                        host/cgi-      binds         transcripti   germs,
                 LEF-1L,                       bin/biobas     across        on            whisker
                 lymphoid                      e/transfac/    the           complex       follicles
                 enhancer mouse,               7.4/bin/get    narrowed      [13] for      [16]; s.
                 binding   Mus      vertebrate TFProf.cgi     major         expressio     global
T00930   LEF-1   factor 1. musculus s          ?T00930        groove        n in teeth,   field
                                                                the LEF-1     contents
                                                                gene (52      a potent
                                                                kb) is        transcripti
                                                                located       onal
                                                                on            activation
                                                                chromoso      domain
                                                                me 4 [1],     which
                                                                exon          mediates
                                                                structure:    context-
                                                                1,2,3, 3a,    specific
                                                                3b,           activation
                                                                4,5,6,7,8,9   of the
                                                                ,10,11,12     TCFalpha
                                                                [1]           enhancer
                                                                sequence-     [17] can
                                                                specific      form a
                                                                DNA-          complex
                                                                binding is    with beta-
                                                                mediated      catenin
                                                                by the        (in the
                                                                disordere     nucleus)
                 lymphoid                                       d N-          and thus
                 enhancer                                       terminal      activates
                 binding                                        part of       gene
                 factor 1,                                      the L-        transcripti
                 lymphoid                                       shaped        on
                 enhancing                       http://local   HMG           member
                  factor 1,                      host/cgi-      domain        of the
                 human                           bin/biobas     and by its    Wnt-
                 LEF-1,                          e/transfac/    third         /Wingless
                 TCF-       human,               7.4/bin/get    alpha-        -signal
                 1alpha,    Homo      vertebrate TFProf.cgi     helix [16]    transducti T-cells;
T02905   LEF-1   hLEF-1.    sapiens   s          ?T02905        binds to      on          thymus
                                                                     heterodim
                                                                     er for
                                                                     individual
                                                                     polypeptid
                                                                     es see rat
                                                                     USF-1
                                                                     <T00875>
                                                                      and rat
                                                                     USF-2
                                                                     <T02115>

                                                                     previously
                                                                      known
                                                                     nuclear      activator
                                                                     activity     of
                                                      http://local   CIIIB1       apolipopro
                                                      host/cgi-      was          tein
                                                      bin/biobas     identified   genes
                                 rat,                 e/transfac/    with USF-    apoCIII
                                 Rattus               7.4/bin/get    1/USF-2      and
         USF-                    norvegicu vertebrate TFProf.cgi     heterodim    apoAII [3]
T05262   1:USF-2   CIIIB1.       s         s          ?T05262        ers [2]      [2] [1]    NULL



                   USF II,
                   USF44,                             http://local
                   FIP, Fos-                          host/cgi-
                   interacting                        bin/biobas                  constant
                    protein,     rat,                 e/transfac/                 levels in
                   upstream      Rattus               7.4/bin/get                 fasted
                   stimulator    norvegicu vertebrate TFProf.cgi                  and refed
T02115   USF2      y factor 2.   s         s          ?T02115                     rats [1]  ubiquitous
                                                                     p50
                                                                     <T00389>

                                                                   homodime
                                                                   r or
                                                                   p50/p65
                                                      http://local heterodim
                   NF-                                host/cgi- er
                   kappaB,                            bin/biobas <T00389>
                   NF-           rat,                 e/transfac/
                   kappaB        Rattus               7.4/bin/get <T05016>
         NF-       complex,      norvegicu vertebrate TFProf.cgi (or
T00587   kappaB    p50/p65.      s         s          ?T00587 similar)                      NULL
                                                                constituen
                                                                t
                                                                complexe
                                                                s may be
                                                                p50
                                                                <T01923>

                                                                homodime
                                                                rs or
                                                                heterodim
                                                                ers of
                                                                p50/p65
                                                                <T01923> inducible
                                                                             activator,
                                                                <T00595> induced
                                                                ,            by many
                                                                p50/RelB agents: e.
                                                                <T01923> g. TNF
                                                                             [17], PKA-
                                                 http://local   <T01932> or PKC-
                  NF-                            host/cgi-      , or p50/c- mediated
                  kappaB,                        bin/biobas     Rel          signals,
                  NF-                            e/transfac/    <T01923> dsRNA
                  kappaB     mouse,              7.4/bin/get                 [31] [26]
         NF-      complex,   Mus      vertebrate TFProf.cgi     <T00169> [22] [13]
T00588   kappaB   p50/p65.   musculus s          ?T00588         [7] [6] [3] [4] [5]    NULL
                                                                                 inducible
                                                                                 activator,
                                                                                 induced
                                                                                 by many
                                                                                 agents: e.
                                                                    described    g., TNF
                                                                    as DNA-      [24], PKA-
                                                                    binding       or PKC-
                                                                    activity,    mediated
                                                                    constitute   signals,
                                                                    d either     dsRNA
                                                                    by a p50     [52] [41]
                                                                    homodime     [32] [17]
                                                                    r            [37] [9]
                                                                    <T00593>     heterodim
                                                                    ,a           ers
                                                                    p50/p65      p50/p65
                                                                    heterodim    are
                                                                    er           inducible
                                                                    <T00593>     by
                                                                                 neuropepti
                                                                    <T00594>     de
                                                                     (or         Substanc
                                                                    related      e P and
                                                                    componen     this
                                                                    ts), or a    induction
                                                     http://local   heterotetr   depends
                    NF-                              host/cgi-      amer         on
                    kappaB,                          bin/biobas     Zn2+-        intracellul
                    NF-                              e/transfac/    dependent    ar Ca2+
                    kappaB     human,                7.4/bin/get     DNA-        mobilizatio
         NF-        complex,   Homo       vertebrate TFProf.cgi     binding      n [1] key
T00590   kappaB     p50/p65.   sapiens    s          ?T00590        [16]         regulator ubiquitous

                                                                    isolated
                                                    http://local    from
                                                    host/cgi-       nuclear
                                                    bin/biobas      extracts
                               rabbit,              e/transfac/     from
                               Oryctolag            7.4/bin/get     rabbit
         NF-                   us        vertebrate TFProf.cgi      liver and
T05148   kappaB     p50/p65.   cuniculus s          ?T05148         kidney                 NULL


                                                     http://local
                                                     host/cgi-
                                                     bin/biobas
                                                     e/transfac/
         NF-        NF-        human,                7.4/bin/get
         kappaB(-   kappaB(-   Homo       vertebrate TFProf.cgi
T00591   like)      like).     sapiens    s          ?T00591                               NULL
                                                   http://local
                                                   host/cgi-
                                                   bin/biobas
                                                   e/transfac/
         NF-        NF-        mouse,              7.4/bin/get
         kappaB(-   kappaB(-   Mus      vertebrate TFProf.cgi
T00592   like)      like).     musculus s          ?T00592                               NULL


                                                                  constitutiv
                                                                  ely
                                                                  expressed

                                                                 synthesize
                                                                 d as a
                                                                 precursor
                                                                 <T01926>
                                                                  binds to
                                                                 DNA as
                                                    http://local homo- or
                                                    host/cgi- heteromer
                                                    bin/biobas                  implicated
                               rat,                 e/transfac/ <T00587>         in MHC
                               Rattus               7.4/bin/get 2 zinc          class II
         NF-        H2TF1,     norvegicu vertebrate TFProf.cgi finger           expressio
T00389   kappaB1    KBF1.      s         s          ?T00389 motifs              n          NULL
                                                                  N-           primary
                                                                  terminal     DNA-
                                                                  half of a    binding
                                                                  105 kDa      subunit of
                                                                  precursor    NF-
                                                                  <T01925>     kappaB
                                                                   [36]        homodime
                                                                  binds to     rs may
                                                                  DNA          repress
                                                                  either as    transcripti
                                                                  homo- or     on [19]
                                                                  heteromer    [23] [13]
                                                                               hyperposp
                                                                  <T00590>     horylation
                                                                   with        in the
                                                                  RelA/p65     cytosol of
                                                                  <T00594>     T cells by
                                                                   [32] Cys-   a 43 kDa
                                                                  62 is part   protein
                                                                  of a         kinase
                   243/NFA-                                       R(F/G)(R/    which is
                   kappaB,                                        K)YXCE       associate
                   EBP-1,                                         motif        d with the
                   H2TF1,                                         found in     NF-
                   HeLa B                                         also other   kappaB/Ik
                   factor,                                        Rel          appaB
                   KBF1,                           http://local   proteins     complex
                   NF-                             host/cgi-      as well as   [3] [6]
                   kappaB                          bin/biobas     in zinc      phosphory
                   (p50), NF-                      e/transfac/    finger       lation of
                   kappaB1, human,                 7.4/bin/get    proteins     p50 may
         NF-       p110, TC- Homo       vertebrate TFProf.cgi     that bind    contribute
T00593   kappaB1   IIB.       sapiens   s          ?T00593        to           to NF-      ubiquitous
                                                            synthesizetranscripti
                                                            d as a    onally
                                                            105 kDa   inert DNA-
                                                            precursor binding
                                                            <T01924>  subunit of
                                                             from     holo-NF-
                                                            which the kappaB
                                                            N-        <T00588>
                                                            terminal   trans-
                                                            half      activating
                                                            comprisin induced
                                                            g the Rel heterodim
                                                            domain is es with
                                                            released  RelA/p65
                                                            as        <T00595>
                                                            mature     [7] or
                                                            p50 by    with Bcl-3
                                                                      [5] at
                                                            proteolytic
                                                             clipping some
                                                            [13] bindselements,
                                                            to DNA    however,
                                                            as homo-  p50 may
                                                            or        exert a
                                                            heteromer constitutiv
                   243/NFA-                                           e
                   kappaB,                                   <T00588> activating
                   EBP-1,                       http://local with, e. function
                   H2TF1,                       host/cgi- g.,         [8] bound
                   KBF1,                        bin/biobas RelA/p65 to this
                   NF-                          e/transfac/ or c-Rel  sequence,
                   kappaB   mouse,              7.4/bin/get [4] the    p50
         NF-       (p50),   Mus      vertebrate TFProf.cgi DNA-       adopts a
T01923   kappaB1   p50.     musculus s          ?T01923 binding       chymotryp ubiquitous
                                                                            transcripti
                                                                            onally
                                                                            inert
                                                                            precursor
                                                                            form,
                                                                            exclusivel
                                                                            y found in
                                                                            the
                                                                precursor cytoplasm
                                                                of the NF-
                                                                kappaB      alternative
                                                                p50          splice
                                                                <T01923> variants
                                                                 subunit    NF-
                                                                [2]         kappaB
                                                                alternative (p98) and
                                                                 splicing NF-
                                                                leads to    kappaB
                                                                NF-         (p84) are
                                                                kappaB      found
                                                                (p98) and also in
                                                                NF-         the
                                                                kappaB      nucleus
                                                                (p84), the [1] only
                   KBF1,                                        latter      NF-
                   p110,                         http://local   lacking     kappaB
                   p105, NF-                     host/cgi-      most of     (p98) can
                   kappaB1                       bin/biobas     the C-      act as a
                   (p105),                       e/transfac/    terminal    transcripti
         NF-       NF-       mouse,              7.4/bin/get    ankyrin     onal
         kappaB1 kappaB1 Mus          vertebrate TFProf.cgi     repeats     activator
T01924   precursor (p110).   musculus s          ?T01924        [1]         [1]         ubiquitous
                                                                    105 kDa        inducible
                                                                    precursor      by a
                                                                    of the         variety of
                                                                    mature         inducers
                                                                    transcripti    C-
                                                                    on factor      terminal
                                                                    NF-            sequence
                                                                    kappaB         s
                                                                    p50            comprisin
                                                                    subunit        g the
                                                                    <T00593>       ankyrin
                                                                     [18] the      repeats
                                                                    precursor      can act
                                                                    interacts      as
                                                                    with           IkappaB-
                                                                    processed      like
                                                                     p50           inhibitor:
                                                                    through        IkappaB-
                                                                    its            gamma
                                                                    ankyrin        [7]
                                                                    repeats        nuclear
                                                                    and            translocati
                                                                    inhibits its   on of p50
                                                                    nuclear        or p65
                                                                    translocati    may be
                   KBF1,                                            on [4] by      controlled
                   p110,                             http://local   masking        by
                   p105, NF-                         host/cgi-      the NLS        heterodim
                   kappaB1                           bin/biobas     signal         erization
                   (p110),                           e/transfac/    intra- and     with the
         NF-       NF-       human,                  7.4/bin/get    intermolec     p105
         kappaB1 kappaB1 Homo             vertebrate TFProf.cgi     ularly [5]     precursor
T01925   precursor (p105).   sapiens      s          ?T01925        this           [4]         ubiquitous

                   KBF1,
                   p110,                            http://local
                   p105, NF-                        host/cgi-
                   kappaB1                          bin/biobas
                   (p105),     rat,                 e/transfac/     precursor
         NF-       NF-         Rattus               7.4/bin/get     of NF-
         kappaB1 kappaB1       norvegicu vertebrate TFProf.cgi      kappeB1
T01926   precursor (p110).     s         s          ?T01926         <T00389>                  ubiquitous
                                                                              constitutiv
                                                                              e
                                                                              activator
                                                                              when
                                                                              heterodim
                                                                              erized
                                                                              with RelB
                                                                              [4]
                                                                              transcripti
                                                                              onally
                                                                              inert DNA-
                                                                              binding
                                                                              homodime
                                                                              r forms
                                                                              trans-
                                                                              activating
                                                                              ternary
                                                                              complexe
                                                                              s with Bcl-
                                                                              3 [5] [1]
                                                                N-            the
                                                                terminal      NFKB2
                                                                half of a     gene
                                                                100-kDa       contains
                                                                precursor     two
                                                                <T01927>      promoters
                                                 http://local    from          [3] at
                   Lyt-10,                       host/cgi-      which it is   least four
                   NF-                           bin/biobas     released      kappaB
                   kappaB2,                      e/transfac/    by            sites
                   p52, NF- human,               7.4/bin/get    proteolytic   mediate
         NF-       kappaB2 Homo       vertebrate TFProf.cgi      clipping     positive
T00394   kappaB2   (p52).   sapiens   s          ?T00394        [7]           autoregula ubiquitous
                                                                           activator
                                                                           when
                                                                           present
                                                                           as
                                                                           heterodim
                                                                           er with
                                                                           RelA
                                                                           (p65)
                                                                           through
                                                                           certain
                                                              the          kappaB
                                                              homodime     sites
                                                              r binds to   (such as
                                                              a kappaB     GGGGAC
                                                              site (of     TTTCC),
                                                              HIV-1        but
                                                              LTR) with    inactive
                                                              KD =         at others
                                                              69.1 pM,     (e. g.,
                                                              i. e. with   GGGAAT
                                                              6-fold       CCC of
                                                              lower        MHC H-2
                                                              affinity     genes)
                                                              than         despite
                                                              p49/p65      higher
                                                              heterodim    binding
                                               http://local   ers (KD=     affinity [1]
                                               host/cgi-      11.8 pM),    [2] the
                                               bin/biobas     and even     p49/p65
                                               e/transfac/    less than    heterodim
         NF-              human,               7.4/bin/get    p50          er is
         kappaB2          Homo      vertebrate TFProf.cgi     homodime     under
T01930   (p49)     p49.   sapiens   s          ?T01930        rs [1]       negative ubiquitous
                                                                              heterodim
                                                                              ers with
                                                                              RelB or c-
                                                                              Rel are
                                                                              retained
                                                                              in the
                                                                              cytoplasm
                                                                               unless
                                                                              an
                                                                              appropriat
                                                                              e
                                                                  DNA-        stimulus
                                                                  binding     causes
                                                                  precursor phosphory
                                                                  of mature lation and
                                                                  NF-         proteolytic
                                                                  kappaB2
                   H2TF1,                                         (p52) [3] processin
                   p100,                                          [2] KD for g of the
                   p97,                                           binding to precursor
                   p98/p55,                        http://local   a kappaB with
                   NF-                             host/cgi-      site is 30 concomita
                   kappaB2                         bin/biobas     pM [2] an nt NF-
                   (p100),                         e/transfac/    alternative kappaB2
         NF-       NF-        human,               7.4/bin/get     splice     (p52)
         kappaB2 kappaB2      Homo      vertebrate TFProf.cgi     variant is release
T01927   precursor (p97).     sapiens   s          ?T01927        p49 [6]     [3] [4] [1] ubiquitous
                   H2TF1,
                   p100,
                   p97,
                   p98/p55,                        http://local
                   NF-                             host/cgi-
                   kappaB2                         bin/biobas
                   (p100),                         e/transfac/
         NF-       NF-        chick,               7.4/bin/get different
         kappaB2 kappaB2      Gallus    vertebrate TFProf.cgi sequence
T01929   precursor (p97).     gallus    s          ?T01929 in Ref. [1]                   NULL


                                                  http://local               induced
                                                  host/cgi-                  by tumor
                   NF-                            bin/biobas                 necrosis
                   kappaB-                        e/transfac/                factor
                   like       mouse,              7.4/bin/get                alpha
                   factor,    Mus      vertebrate TFProf.cgi                 (TNF-
T00606   NF-TNF    NF-TNF.    musculus s          ?T00606                    alpha)      NULL
                                                 http://local               induced
                                                 host/cgi-                  by tumor
                  NF-                            bin/biobas                 necrosis
                  kappaB-   rat,                 e/transfac/                factor
                  like      Rattus               7.4/bin/get                alpha
                  factor,   norvegicu vertebrate TFProf.cgi                 (TNF-
T01224   NF-TNF   NF-TNF.   s         s          ?T01224 four AA            activator NULL
                                                                            alpha)
                                                              residues      contribute
                                                              in the        s the
                                                              DNA-          major
                                                              binding       transcripti
                                                              Rel           on
                                                              domain        activation
                                                              mediate a     domain to
                                                              distinct      the NF-
                                                              DNA-          kappaB
                                                              binding       <T00590>
                                                              specificity    complex
                                                              of the        [26] at
                                                              RelA          some
                                                              (p65)         sequence
                                                              homodime      s, its
                                                              r             homodime
                                                              compared      rs may
                                                               to           act as
                                                              heterodim     transcripti
                                                              ers [14]      onal
                                                              cytoplasmi    activators
                                                              c             [25] [28]
                                                              inhibitors    synergistic
                                                              (IkappaB-      effects
                                                              alpha and     with AP-1
                                                 http://local -beta)        through
                                                 host/cgi- bind to          AP-1
                  NF-                            bin/biobas the Rel         sites as
                  kappaB                         e/transfac/ domain of      well as
                  (p65),    human,               7.4/bin/get RelA [31]      through
                  Rel-A,    Homo      vertebrate TFProf.cgi [30] thus       kappaB
T00594   RelA     p65.      sapiens   s          ?T00594 masking            sites (c-   ubiquitous
                                                             the Rel       the
                                                             domain        heterodim
                                                             constitute    er with
                                                             s the         p50
                                                             DNA-          avidly
                                                             contacting    binds to
                                                              domain       asymmetri
                                                             either in     c DNA-
                                                             homo- or      sequence
                                                             in            s at some
                                                             heterodim     sequence
                                                             ers [7]       s, its
                                                             the           homodime
                                                             affinity of   rs may
                                                             the           act as
                                                             homodime      transcripti
                                                             r to          onal
                                                             kappaB        activators
                                                             sites is 4-   [7] target
                                                             fold to 13-   for the
                                                             fold lower    cytoplasmi
                                                             than that     c inhibitor
                                                             of            IkappaB
                                                             p50/p65       [10] [8]
                                                             heterodim     RelA
                                                             ers           establishe
                                             http://local    <T00588>      s an
                                             host/cgi-        [5]          autoregua
                NF-                          bin/biobas      cytoplasmi    tory loop
                kappaB                       e/transfac/     c             by
                (p65),   mouse,              7.4/bin/get     inhibitors    activating
                Rel-A,   Mus      vertebrate TFProf.cgi      (IkappaB-     the
T00595   RelA   p65.     musculus s          ?T00595         alpha and     IkappaB- ubiquitous


                                              http://local
                                              host/cgi-
                NF-                           bin/biobas
                kappaB   rat,                 e/transfac/    constituen
                (p65),   Rattus               7.4/bin/get    t of NF-
                Rel-A,   norvegicu vertebrate TFProf.cgi     kappaB
T05016   RelA   p65.     s         s          ?T05016        <T00587>                NULL
                                                                conserved     required
                                                                 C-           for
                                                                terminal      transcripti
                                                                part, 88%     on by
                                                                identity      polymeras
                                                                with          e I, II, and
                                                                Drosophil     III [31]
                                                                a and         basal
                                                                80%           transcripti
                                                                identity      on by pol
                                                                with yeast    II is
                                                                TBP [48]      mediated
                                                                [42] some     by TBP,
                                                                homology      upstream
                                                                with          activator
                                                                bacterial     effects by
                                                                IHFs with     TBP-
                                                                the two       TAF(II)
                                                                direct        complexe
                                                                repeats       s (TFIID)
                                                                within the    alone
                                                                conserved     functional
                                                                 part [39]    on TATA-
                                                                the           containing
                                                                divergent      pol III
                                                                N-            promoters
                                                 http://local   terminal      , on
                 TBP,                            host/cgi-      part is       TATA-
                 TFIID,                          bin/biobas     required      less pol
                 TFIIDtau,                       e/transfac/    for TATA-     III
                 TATA-     human,                7.4/bin/get    containing    promoters
                 binding   Homo       vertebrate TFProf.cgi      pol II and    only as B-
T00794   TBP     protein.  sapiens    s          ?T00794        pol III       TFIID        ubiquitous


                                               http://local
                 TBP,                          host/cgi-
                 TFIID,                        bin/biobas                     is part of
                 TFIIDtau,                     e/transfac/                    TFIID
                 TATA-     mouse,              7.4/bin/get                    binds to
                 binding   Mus      vertebrate TFProf.cgi                     DNA as a
T00796   TBP     protein.  musculus s          ?T00796                        monomer ubiquitous

                                                                              TATA-
                                                                compositi     box-
                                                 http://local   on: TBP       binding
                                                 host/cgi-      + TAF-        complex
                                                 bin/biobas     250 +         of TBP
                                                 e/transfac/    TAF-125       and TAFs
                 dTFIID,   human,                7.4/bin/get    + TAF-95      can be
                 TAB,      Homo       vertebrate TFProf.cgi     + TAF-78      competed
T00820   TFIID   TFIID.    sapiens    s          ?T00820        + TAF-50      by En    NULL
                                                     http://local
                                                     host/cgi-
                                                     bin/biobas
                                                     e/transfac/
                               chick,                7.4/bin/get
                               Gallus     vertebrate TFProf.cgi
T00821   TFIID     TFIID.      gallus     s          ?T00821                 NULL


                                                   http://local
                                                   host/cgi-
                                                   bin/biobas
                                                   e/transfac/
                               mouse,              7.4/bin/get
                               Mus      vertebrate TFProf.cgi
T01159   TFIID     TFIID.      musculus s          ?T01159                   NULL


                                                    http://local
                                                    host/cgi-
                                                    bin/biobas
                               rat,                 e/transfac/
                               Rattus               7.4/bin/get
                               norvegicu vertebrate TFProf.cgi
T01175   TFIID     TFIID.      s         s          ?T01175                  NULL



                   HNF4,                                            activator
                   HNF-4,                                           [2]
                   hepatocyt                                        maternally
                   e nuclear                         http://local    provided,
                   factor 4,                         host/cgi-      forming
                   hepatocyt                         bin/biobas     an animal
                   e nuclear   clawed                e/transfac/    to vegetal
                   factor      frog,                 7.4/bin/get    gradient
         HNF-      4alpha1,    Xenopus    vertebrate TFProf.cgi     in the
T02429   4alpha1   NR2A1.      laevis     s          ?T02429        embryo [2] NULL

                   COUP,
                   COUP-
                   TF,
                   chicken                           http://local
                   ovalbumin                         host/cgi-
                                                     bin/biobas
                   upstream                          e/transfac/
                   promoter chick,                   7.4/bin/get
                   transcripti Gallus     vertebrate TFProf.cgi
T00148   COUP      on factor. gallus      s          ?T00148                 NULL
                                                  http://local
                                                  host/cgi-
                                                  bin/biobas
                                                  e/transfac/
                                                  7.4/bin/get
                NF-1, NF- cat, Felis   vertebrate TFProf.cgi
T00533   NF-1   I.        catus        s          ?T00533                NULL


                                              http://local
                                              host/cgi-
                                              bin/biobas
                         monkey,              e/transfac/
                         Cercopith            7.4/bin/get
                CTF, NF- ecus      vertebrate TFProf.cgi
T00534   NF-1   1, NF-I. aethiops s           ?T00534                    NULL


                                                http://local
                CTF, NF-                        host/cgi-
                1, NF-I,                        bin/biobas
                TGGCA-     rat,                 e/transfac/
                binding    Rattus               7.4/bin/get O-
                protein    norvegicu vertebrate TFProf.cgi glycosylati
T00535   NF-1   (chick).   s         s          ?T00535 on               NULL


                                                  http://local
                                                  host/cgi-
                                                  bin/biobas
                                                  e/transfac/
                         clawed                   7.4/bin/get
                CTF, NF- frog,         vertebrate TFProf.cgi
T00536   NF-1   1, NF-I. Xenopus       s          ?T00536                (oocytes)
                                                                nuclear
                                                                activity
                                                                presently,
                                                                4
                                                                different
                                                                genes
                                                                encoding
                                                                NF-
                                                                1/CTF
                                                                factors in
                CCAAT-                                          mouse
                binding                                         are
                factor,                                         known:
                CCAAT                                           NFIA,
                box-                                            NFIB
                binding                                         <G005252
                transcripti                                     >, NFIC,
                on factor,                                      NFIX
                CTF, NF-                                        NFIB
                1, NF-1 (-                                      gene
                like                                            produces
                proteins),                                      several
                NF-1-like,                                      splice
                NF-I,                                           variants,
                TGGCA-                                          see
                binding                                         entries:
                protein,                        http://local    NF1-B2
                CCAAT-                          host/cgi-       <T01909>
                box                             bin/biobas      , NF1-B3
                binding                         e/transfac/     <T01910>
                transcripti mouse,              7.4/bin/get     , NF1-B4
                on factor, Mus       vertebrate TFProf.cgi      <T01911>
T00537   NF-1   ctf/nf-1.   musculus s          ?T00537          O-          NULL


                                                 http://local
                                                 host/cgi-
                CTF, NF-                         bin/biobas
                1, NF-I,                         e/transfac/
                TGGCA- domestic                  7.4/bin/get
                binding  pig, Sus     vertebrate TFProf.cgi
T00538   NF-1   protein. scrofa       s          ?T00538                     NULL
                                                                6 splice
                                                                variants
                                                                are
                                                                known:
                                                                NF-1 (this
                                                                entry),
                                                                CTF-1
                                                                <T00176>
                                                                , CTF-2
                                                                <T00177>
                                                                , CTF-3
                CTF, NF-                                        <T00178>
                1, NF-I,                         http://local   , CTF-5
                TGGCA-                           host/cgi-      <T02300>
                binding                          bin/biobas     , CTF-7
                protein,                         e/transfac/    <T02301>
                NFIC1,     human,                7.4/bin/get     [2] [1] O-
                NFIC       Homo       vertebrate TFProf.cgi     glycosylati
T00539   NF-1   isoform 1. sapiens    s          ?T00539        on            NULL


                                                 http://local
                                                 host/cgi-
                CTF, NF-                         bin/biobas
                1, NF-I,                         e/transfac/
                TGGCA-                           7.4/bin/get
                binding               vertebrate TFProf.cgi
T01036   NF-1   protein. hamster      s          ?T01036                      NULL


                                                http://local
                                                host/cgi-
                                                bin/biobas
                                                e/transfac/
                                                7.4/bin/get
                NF-1, NF- sheep,     vertebrate TFProf.cgi
T01298   NF-1   I.        Ovis aries s          ?T01298                       NULL
                                                                    both
                                                                    subdomai
                                                                    ns of the
                                                                    DBD, the
                                                                    outer N-
                                                                    terminal
                                                                    part
                                                                    (unspecifi
                                                                    cally
                                                                    binding to
                                                                    DNA) and
                                                                    the C-
                                                                    terminal
                                                                    part of
                                                                    the DNA-
                                                                    binding
                                                                    domain
                                                                    (low-
                                                                    affinity,
                                                                    but
                                                                    specific
                                                                    binding),
                                                                    have to
                                                                    cooperate
                                                                     for
                                                                    specific
                  NF1/L,                            http://local    and high-
                  RPF-A                             host/cgi-       affinity
                  (hamster),                        bin/biobas      binding to
                   NF-         rat,                 e/transfac/     DNA [1]      activator
                  1A1.1        Rattus               7.4/bin/get     the N-       of
                  (chick),     norvegicu vertebrate TFProf.cgi      terminal     replication
T00599   NF-1/L   NF-I/L.      s         s          ?T00599         subdomai      [1]        (liver)
                                                                                 may act
                                                                                 as a
                                                                                 repressor
                                                     http://local                (e.g. on
                  NF-1B1                             host/cgi-                   the
                  (chick),                           bin/biobas                  proenkep
                  NF-                                e/transfac/                 halin
                  1/Red1,                            7.4/bin/get                 upon
         NF-      NFI-B1,                 vertebrate TFProf.cgi                  cotransfec
T00604   1/Red1   RPF-B.       hamster    s          ?T00604                     tion)       NULL
                                                                six splice
                                                                variants
                                                                encoded
                                                 http://local   by the NF-
                                                 host/cgi-      1A gene
                                                 bin/biobas     are
                  NF-1A1,                        e/transfac/    known:
                  NFI-A1,    chick,              7.4/bin/get    A1, A1.1,
                  RPF-A      Gallus   vertebrate TFProf.cgi     A3, A4,
T00544   NF-1A1   (hamster). gallus   s          ?T00544        A5, A6 [1]   NULL


                                                 http://local
                  NF-1B1,                        host/cgi-
                  NF-                            bin/biobas
                  1/Red1                         e/transfac/
                  (hamster), chick,              7.4/bin/get splice
                   NFI-B1, Gallus     vertebrate TFProf.cgi variant:
T00551   NF-1B1   RPF-B.     gallus   s          ?T00551 NF-1B2              NULL


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                                                 e/transfac/
                             chick,              7.4/bin/get splice
                  NF-1B2,    Gallus   vertebrate TFProf.cgi variant:
T00552   NF-1B2   NFI-B2.    gallus   s          ?T00552 NF-1B1              NULL

                                                                3-4 splice
                                                                variants
                                                                encoded
                                                                by the NF-
                                                                1C gene:
                                                                NF-
                                                                1C1/CTF-
                                                                1, NF-
                                                 http://local   1C2/CTF-
                                                 host/cgi-      2, NF-
                                                 bin/biobas     1C4 and
                  CTF-2                          e/transfac/    (from
                  (human),   chick,              7.4/bin/get    human
                  NF-1C2,    Gallus   vertebrate TFProf.cgi     sources)
T00554   NF-1C2   NFI-C2.    gallus   s          ?T00554        CTF-3 [1]    NULL
                                                http://local
                                                host/cgi-
                                                bin/biobas
                                                e/transfac/
                                                7.4/bin/get
                 NF-1/X,             vertebrate TFProf.cgi
T00610   NF-1X   NFI-X.    hamster   s          ?T00610 CD,                activator     NULL
                                                             NMR,          [13] [8]
                                                             fluorescen    may
                                                             ce: DNA-      cooperate
                                                             binding        with SRF
                                                             domain is     or MCM1
                                                             an            on some
                                                             independe     promoters
                                                             ntly           [13] [8]
                                                             folded        ternary
                                                             domain of     complex
                                                             alpha-        formation
                                                             helices       with SRE
                                                             and beta-     and SRF
                                                             sheet         is
                                                             elements,     independe
                                                             the 3         nt of
                                                             conserved     orientation
                                                              Trp           and
                                                             being part    distance
                                                             of a          to the
                                                             hydrophob     SRF site
                                                             ic core [2]   growth      lung,
                                                             high DNA-     factor-     testis;
                                                             binding       dependent   HeLa,
                                                             affinity                  BL2,
                                                http://local (Kd = 85      phosphory Ramos,
                                                host/cgi- pM) and          lation in   K562,
                                                bin/biobas specificity     vivo at     Jurkat,
                                                e/transfac/ [2] no         MAP         E418,
                 Elk-1,    human,               7.4/bin/get significant    kinase in Saos,
                 p62TCF,   Homo      vertebrate TFProf.cgi bending         vitro sites IARC-
T00250   Elk-1   TCF-A.    sapiens   s          ?T00250 induced            enhances EW17 [1]
                                                                IAD
                                                                domain,
                                                                conserved
                                                                 within
                                                                IRF
                                                 http://local   family, is
                                                 host/cgi-      responsibl
                                                 bin/biobas     e for
                                                 e/transfac/    protein-
                  interferon human,              7.4/bin/get    protein
                  regulatory Homo     vertebrate TFProf.cgi     interaction
T04674   IRF-7A   factor 7. sapiens   s          ?T04674        s [2]                    NULL


                                                                              transcripti
                                                                              onal
                                                                              repressor,
                                                                               acting
                                                                N-            through
                                                                terminal      ISREs
                                                                115 AA        thus
                                                                have 45%      being an
                                                                identity      IRF-1
                                                                with IRF-     antagonist
                                                                1, 47%         [3] also
                                                                identity      inhibiting
                                                                with IRF-     binding of
                                                                2 [5] no      ISGF3 to
                                                                similarity    ISREs [2]
                                                                with IRFs     mRNA
                                                                for the C-    induced
                                                                terminal      by IFN-
                                                                309 AA        gamma,
                                                                direct        not by
                                                                interaction   IFN-
                  ICSBP,                                         with         alpha/beta
                  IFN                                           either         [5]
                  consensu                     http://local     IRF-1 or      transcripti
                  s                            host/cgi-        IRF-2         on is
                  sequence                     bin/biobas       enhances      activated
                  binding                      e/transfac/      DNA-          through a
                  protein, mouse,              7.4/bin/get      binding       STAT-like
                  IRF-8,   Mus      vertebrate TFProf.cgi       capability    element     spleen,
T00402   ICSBP    IRF8.    musculus s          ?T00402          [2]           [4]         thymus [5]
                 IFN
                 consensu                                                             13d:
                 s                                                                    widesprea
                 sequence                                                             d; 18d:
                 binding                                                              highest
                 protein,                                                             level in
                 ICSBP,                                                               spleen,
                 ICSbp1,                                                              moderate
                 Interferon                                                           in gut.
                 Consensu                                                  induced    lung, mid-
                 s                              http://local               by         and
                 Sequence                       host/cgi-                  recombina hindbrain,
                  binding                       bin/biobas                 nt ChIFN low in
                 protein,                       e/transfac/                type I and lens,
                 icsbp1,    chick,              7.4/bin/get                ChIFN-     heart,
                 IRF8, IRF- Gallus   vertebrate TFProf.cgi                 gamma      forebrain
T02037   ICSBP   8.         gallus   s          ?T02037        within IRF  [1]        [2]
                                                               family,
                                                               demonstr
                                                               ates the
                                                               highest
                                                               homology
                                                               to IRF-4
                                                               binds to
                                                               DNA in a
                                                               complex
                                                               with IRF-
                                                               1 or IRF-
                                                               2, or
                                                               cooperativ
                                                               ely with
                                                               PU.1 or
                                                               E47 IAD
                                                               of ICSBP
                                                               is
                                                               responsibl
                                                               e for the
                                                               interaction alone,
                                                               s with IRF cannot
                                                               family      activate
                                                               members, transcripti
                 IFN                                            IRF-       on [1]
                 consensu                       http://local   1and IRF- activator
                 s                              host/cgi-      2 [2] IAD in
                 sequence                       bin/biobas     is          cooperatio
                 binding                        e/transfac/    responsibl n with      lymphoid
                 protein, human,                7.4/bin/get    e for the PU.1 or      and
                 IRF-8,   Homo       vertebrate TFProf.cgi     interaction E47 [2]    myeloid
T02038   ICSBP   IRF8.    sapiens    s          ?T02038        s with Ets [1].        cells
                                                                            positive
                                                                            regulator
                                                                            of
                                                                            interferon-
                                                                            beta
                                                                            expressio
                                                                            n binds
                                                                            with the
                                                                            N-
                                                                            terminal
                                                                            part to
                                                                            interferon-
                                                                             and to
                                                                            virus-
                                                              IAD2          inducible
                                                              domain is     enhancer
                                                              conserved     elements
                                                               between      [14] same
                                                              IRF-1         DNA
                                                              and IRF-      binding
                                                              2, but is     specificity
                                                              different     as IRF-2
                                                              in other      the C-
                                                              family        terminal
                                                              members       part
                                                              [1] IAD2      comprises
                                               http://local   is             a trans-
                 IRF-1,                        host/cgi-      responsibl    activating
                 ISGF2,                        bin/biobas     e for         domain
                 IRF1,                         e/transfac/    protein-      [12]
                 Interferon mouse,             7.4/bin/get    protein       inducible
                 regulatory Mus     vertebrate TFProf.cgi     interaction   by IL-6 [4]
T00422   IRF-1   factor 1. musculus s          ?T00422        s [1]         immediate NULL
                                                                             positive
                                                                             regulator
                                                                             of
                                                                             interferon-
                                                                             beta and
                                                                             IFN-
                                                                             induced
                                                                             genes
                                                                             [11]
                                                               M-form        tumor
                                                               appears       suppresso
                                                               as 56-        r
                                                               kDa           antagonizi
                                                               protein       ng IRF-2
                                                               IAD2          transformi
                                                               domain is     ng
                                                               conserved     potential
                                                                between      [9]
                                                               IRF-1         deleted in
                                                               and IRF-      some
                                                               2, but is     leukemias
                                                               different      and
                                                               in other      myelodys
                                                               family        plasias
                                                               members       showing
                                                               [2] IAD2      cytogeneti
                                                http://local   is            c
                 IRF-1,                         host/cgi-      responsibl    abnormalit
                 ISGF2,                         bin/biobas     e for         ies of
                 IRF1,                          e/transfac/    protein-      chromoso
                 Interferon human,              7.4/bin/get    protein       me 5 [10]
                 regulatory Homo     vertebrate TFProf.cgi     interaction   M- and G-
T00423   IRF-1   factor 1. sapiens   s          ?T00423        s [2]         forms of NULL
                                                                            immediate
                                                              M-form        -early
                                                              appears       gene,
                                                              as 56-        induced
                                                              kDa           by
                                                              protein       prolactin
                                                              IAD2          in
                                                              domain is     lymphoma
                                                              conserved      cells [6]
                                                               between      here, two
                                                              IRF-1         induction
                                                              and IRF-      peaks
                                                              2, but is     have
                                                              different     been
                                                              in other      found at
                                                              family        early G1
                                                              members       and
                                                              [1] IAD2      during
                                               http://local   is            G1/S
                                               host/cgi-      responsibl    transition
                                               bin/biobas     e for         [3] same
                          rat,                 e/transfac/    protein-      DNA
                          Rattus               7.4/bin/get    protein       binding
                 IRF-1,   norvegicu vertebrate TFProf.cgi     interaction   specificity
T00424   IRF-1   ISGF2.   s         s          ?T00424        s [1]         as IRF-2 NULL
                                                                              the N-
                                                                              terminal
                                                                              region
                                                                              contain a
                                                                              characteri
                                                                              stic
                                                                              tryptophan
                                                                               repeat
                                                                homolog       (five
                                                                of            tryptophan
                                                                mammalia      s spaced
                                                                n IRF-1       in 10- 18
                                                                (based of     amino
                                                                an overall    acid
                                                                amino         intervals),
                                                                acid          which is
                                                                identity of   present in
                                                                63 - 65%      all
                                                                and 89 -      members
                                                                91%           of the IRF
                                                                identity      family
                                                                within the    (17698)
                                                                N-            specificall
                                                                terminal      y binds to
                                                                115           the
                                                                residues,     upstream
                                                 http://local   as            regulatory
                                                 host/cgi-      compared      region of
                 IRF-1,                          bin/biobas      with         type I IFN
                 IRF1,                           e/transfac/    hIRF-1        and IFN
                 Interferon chick,               7.4/bin/get    and           inducible
                 Regulator Gallus     vertebrate TFProf.cgi     mIRF-1)       MHC
T05092   IRF-1   y Factor 1. gallus   s          ?T05092        [1]           class I     NULL
                                                                              expressio
                                                                              n
                                                                              inducible
                                                                              by
                                                                              interferon
                                                                              s (IFN1
                                                                              and
                                                                              IFNgamm
                                                                              a: primary
                                                                              fibroblasts
                                                                              ) and
                                                                              concanav
                                                                amino         alin A
                                                                acid          (splenic
                                                                identity to   culture)
                                                                mammalia      and
                                                                n and         dependent
                                                                avian          on
                                                                paralogs:     protein
                                                                about         synthesis
                                                                43% to        (blockable
                                                                IRF-4          by
                                                                <T01572>      cyclohexi
                                                                <T04929>      mide) [1]
                                                                , 36% to      seems
                                                                IRF-8         mainly
                                                 http://local   <T00402>      located in
                                                 host/cgi-      <T02037>      the
                                                 bin/biobas     <T02038>      nucleus
                  IRF10,                         e/transfac/    , less        (when
                  Interferon chick,              7.4/bin/get    than 30%      expressed
                  regulatory Gallus   vertebrate TFProf.cgi     to other       in
T05154   IRF-10   factor 10. gallus   s          ?T05154        IRFs [1]      chicken     NULL
                                                              highly       constitutiv
                                                              similar to   e
                                                              IRF-2        transcripti
                                                              (62%         onal
                                                              identity     repressor,
                                                              within the    thus
                                                              N-           negative
                                                              terminal     regulator
                                                              part, 25%    of
                                                              between      interferon-
                                                              the C-       beta
                                                              terminal     expressio
                                                              sequence     n same
                                                              s), but      DNA
                                                              lacking      binding
                                                              the acidic   specificity
                                                              region of    as IRF-1
                                                              IRF-1        transformi
                                                              [10] IAD2    ng
                                                              domain is    potential,
                                                              conserved    antagonizi
                                                               between     ng IRF-1
                                                              IRF-1        [6]
                                                              and IRF-     required
                                                              2, but is    for
                                                              different    normal
                                               http://local   in other     hematopoi
                                               host/cgi-      family       esis and
                                               bin/biobas     members      B
                 IRF-2,                        e/transfac/    [1] IAD2     lymphopoi
                 PRDI-     mouse,              7.4/bin/get    is           eses [5]
                 BFc,      Mus      vertebrate TFProf.cgi     responsibl   enhanced
T00425   IRF-2   PRDI-BFi. musculus s          ?T00425        e for        levels      NULL
                                                                              negative
                                                                              constitutiv
                                                                              e
                                                                highly        regulator
                                                                similar to    of
                                                                IRF-2 C-      interferon-
                                                                terminally    beta
                                                                truncated     expressio
                                                                forms         n same
                                                                observed      DNA
                                                                after         binding
                                                                virus-        specificity
                                                                inducible     as IRF-1
                                                                proteolysi    truncated
                                                                s [5] IAD2    forms are
                                                                domain is     less
                                                                conserved     efective
                                                                 between      repressor
                                                                IRF-1         s than full-
                                                                and IRF-      length
                                                                2, but is     IRF-2 [5]
                                                                different     enhanced
                                                                in other      levels
                                                                family        after
                                                                members       interferon-
                                                                [1] IAD2      induction
                                                 http://local   is            through
                                                 host/cgi-      responsibl    IRF-1
                                                 bin/biobas     e for         binding to
                                                 e/transfac/    protein-      a ISRE
                 PRDI-     human,                7.4/bin/get    protein       within the
                 BFc,      Homo       vertebrate TFProf.cgi     interaction   IRF-2
T01491   IRF-2   PRDI-BFi. sapiens    s          ?T01491        s [1]         promoter NULL


                                                 http://local
                                                 host/cgi-
                 IRF-2,                          bin/biobas
                 IRF2,                           e/transfac/
                 Interferon chick,               7.4/bin/get
                 Regulator Gallus     vertebrate TFProf.cgi
T05091   IRF-2   y Factor 2. gallus   s          ?T05091                              NULL
                                                                               there is a
                                                                               sharp
                                                                               peak in
                                                                               IRF-3
                                                                               expressio     adult:
                                                                               n2            high in
                                                                               weaks         lung,
                                                                               after birth   spleen,
                                                  http://local                 mRNA          intestine;
                                                  host/cgi-                    can be        low in
                 IRF3,                            bin/biobas                   slightly      hen liver,
                 Interferon                       e/transfac/                  induced       kidney;
                 Regulator chick,                 7.4/bin/get                  in male       embryo:
                 y Factor Gallus       vertebrate TFProf.cgi                   livers by     very low
T01571   IRF-3   3, IRF-3. gallus      s          ?T01571                      estrogen      in liver
                                                                 IAD
                                                                 domain,
                                                                 conserved
                                                                  within
                                                                 IRF
                                                  http://local   family, is
                                                  host/cgi-      responsibl
                 Interferon                       bin/biobas     e for
                 Regulator                        e/transfac/    protein-
                 y Factor human,                  7.4/bin/get    protein
                 3, IRF3,   Homo       vertebrate TFProf.cgi     interaction
T04673   IRF-3   IRF-3.     sapiens    s          ?T04673        s [2]                       NULL


                 INTERFE                         http://local
                 RON                             host/cgi-
                 REGULA                          bin/biobas                    Transcripti
                 TORY                            e/transfac/                   on factor
                 FACTOR mouse,                   7.4/bin/get                   transcripti
                 3, IRF-3, Mus        vertebrate TFProf.cgi                    on
T05128   IRF-3   irf3, IRF3. musculus s          ?T05128                       regulation NULL
                                                                               activator
                                                                               activator
                                                                               of
                                                                               cytokine
                                                                               gene
                                                                 IAD           expressio
                                                                 domain,       n in both
                                                                 conserved     Th1 and
                                                                  within       Th2 cells
                                                                 IRF           [1]
                                                                 family, is    cooperate
                                                                 responsibl    s with NF-
                 IRF4,                                           e for the     ATc upon
                 lymphocyt                                       interaction   IL-4 gene
                 e specific                                      s and         induction
                 interferon                                      synergy       in Th2 [1]
                 regulatory                                      with Ets      activate
                 factor,                          http://local   family        transcripti
                 LSIRF,                           host/cgi-      member        on
                 NF-EM5,                          bin/biobas     PU.1 and      synergistic
                 interferon                       e/transfac/    with          ally with     lymphocyt
                 regulatory human,                7.4/bin/get    bHLH          PU.1 in       es,
                 factor 4, Homo        vertebrate TFProf.cgi     factor        myeloid       myeloid
T04929   IRF-4   MUM1.      sapiens    s          ?T04929        E47 [3] [2]   cells [2]     cells
                                                                 high
                                                                 amino
                                                                 acid
                                                                 identity
                                                                 (77% of
                                                                 <T05117>
                                                                 ) to
                                                                 Xenopus
                                                                 IRF-6
                                                 http://local    <T05117>      expressio
                                                 host/cgi-        which is     n of a
                 IRF-5,                          bin/biobas      most          mammalia
                 IRF5,                           e/transfac/     probably      n IRF-5
                 Interferon mouse,               7.4/bin/get     the frog      ortholog
                 Regulator Mus        vertebrate TFProf.cgi      ortholog      regulated
T05103   IRF-5   y Factor 5. musculus s          ?T05103         [2]           by p53 [1] NULL
                                                                               nuclear
                                                                               translocati
                                                                               on
                                                                 phosphory     obviously
                                                                 lation        regulated:
                                                                 experimen     infection
                                                                 tally         with NDV
                                                                 proven        (Newcastl
                                                                 which is      e disease
                                                                 caused        virus) but
                                                                 for           not with
                                                                 example       Sendai
                                                                 by            virus
                                                                 infection     leads to
                                                                 of the        nuclear
                                                                 correspon     translocati
                                                                 ding cells    on (in
                                                                 with NDV      2fTGH
                                                                 (Newcastl     cells) [1]
                                                                 e disease     does not
                                                                 virus) [1]    bind to or
                                                                 IAD           stimulate
                                                                 domain,       promoter      (adult:)
                                                                 conserved     of IRF-7      spleen,
                                                                  within       gene          lymph
                                                                 IRF           <G002599      node,
                                                  http://local   family, is    > [1]         thymus,
                                                  host/cgi-      responsibl    regulates     peripheral
                 IRF-5,                           bin/biobas     e for         different     blood
                 IRF5,                            e/transfac/    protein-      subset of     leukocytes
                 Interferon human,                7.4/bin/get    protein       IFNA          , bone
                 Regulator Homo        vertebrate TFProf.cgi     interaction   genes         marrow
T05104   IRF-5   y Factor 5. sapiens   s          ?T05104        s [3]         compared      [1]
                                                                  77%
                                                                  amino
                                                                  acid                        (embryo:)
                                                                  identity to                 expressed
                                                                  mouse                        at stages
                                                                  IRF-6                       6, 8, 10,
                                                                  <T05103>                    12 (weak
                                                                   which is                   signals in
                                                                  most                        the
                                                                  probably                    presumpti
                                                                  the                         ve
                                                                  mammalia                    mesoder
                                                                  n ortholog                  m except
                                                                  [1] DNA-                    for the
                                                                  binding                     notochord
                                                                  domain                      ) 14, 16,
                                                                  shared                      18
                                                                  67%                         (somitic
                                                                  amino                       mesoder
                                                                  acid          expressio     m of the
                                                                  identity      n pattern     posterior
                                                                  with          appeared      segment),
                                                                  human         to             20, 25
                                                                  IRF-5         partially     (somitic
                                                                  <T05104>      overlap       mesoder
                                                                  , 45%         with that     m as a
                                                   http://local   with          of the        pair of
                 Interferon                        host/cgi-      mouse         myogenic      small
                 Regulator                         bin/biobas     IRF-1         transcripti   regions
                 y Factor     clawed               e/transfac/    <T00422>      on factor     adjacent
                 6, IRF-6,    frog,                7.4/bin/get     and 42%      XMyf5         to the
                 IRF6,        Xenopus   vertebrate TFProf.cgi     with          <T00949>      midline)
T05117   IRF-6   xIRF-6.      laevis    s          ?T05117        mouse          [1]          [1]


                                                                  direct
                                                                  submissio
                                                   http://local   n of RNA
                                                   host/cgi-      sequence
                 Interferon                        bin/biobas     to EMBL,
                 Regulator                         e/transfac/    no
                 y Factor human,                   7.4/bin/get    cloning
                 6, IRF-6, Homo         vertebrate TFProf.cgi     paper
T05118   IRF-6   IRF6.      sapiens     s          ?T05118        available                   NULL
                                                                direct
                                                                submissio
                                                 http://local   n of RNA
                                                 host/cgi-      sequence
                  Interferon                     bin/biobas     to EMBL,
                  Regulator                      e/transfac/    no
                  y Factor mouse,                7.4/bin/get    cloning
                  6, IRF-6, Mus       vertebrate TFProf.cgi     paper
T05119   IRF-6    IRF6.      musculus s          ?T05119        available                  NULL


                                                   http://local
                                                   host/cgi-
                  IRF7, IRF-                       bin/biobas
                  7,                               e/transfac/
                  Interferon   mouse,              7.4/bin/get
                  regulatory   Mus      vertebrate TFProf.cgi
T05144   IRF-7    factor 7.    musculus s          ?T05144 conflict in       activation    NULL
                                                                protein      of IFNA
                                                                sequence     promoter
                                                                between      in
                                                                EMBL         transient
                                                                entry        transfectio
                                                                #AF07649     n assay
                                                                4 and        which is
                                                                SWISSPR      stronger
                                                                OT entry     upon
                                                                #Q92985:     virus-
                                                                pos. 1-20    induction
                                                                (MALAPE      in
                                                                R instead    uninfected
                                                                of            cells
                                                                MPVPER       overexpre
                                                                PAAGPD       ssed
                                                                SPRPGT       protein
                                                                RR), pos.    present
                                                                425 (R       mainly
                                                                instead of   located in
                                                                Q) differs   the
                                                                from         cytoplasm     (adult:)
                                                                isoform      , whereas     spleen,
                                                                IRF-7A       viral         lymph
                                                                <T04674>     infection     node,
                                                   http://local by 13        increases     thymus,
                                                   host/cgi- amino           nuclear       peripheral
                                                   bin/biobas acids at       translocati   blood
                                                   e/transfac/ the very      on [2]        leukocytes
                  interferon   human,              7.4/bin/get amino-        IRF-3         ,
                  regulatory   Homo     vertebrate TFProf.cgi terminal       interferes    appendix
T05106   IRF-7H   factor 7.    sapiens  s          ?T05106 region            with its      [2]
                                                                               activator
                                                                               essential
                                                                               for
                                                                               function
                                                                               of mature
                  NF-EM5,                                                      B- and T-
                  PU.1                                                         lymphocyt
                  interaction                                                  es [3]
                   partner,                                                    transcripti
                  Pip,                                                         onal
                  lymphoid-                                                    synergy
                  specific                                                     with Ets
                  interferon                                                   family
                  regulatory                                                   factor
                  factor,                                                      PU.1 [4]
                  LSIRF-2,                                                     binds to
                  interferon                                     clones        ISREs
                  regulatory                                     have          induced
                  factor 4,                                      been          in
                  IRF-4,                                         obtained      lymphocyt
                  Lymphocy                                       that code     es by
                  te                                             for a         antigen
                  Specific                                       variant       mimetic
                  Interferon                                     with an       stimuli,
                  Regulator                                      extra Gln-    but not by    B cells,
                  y Factor,                                      164           IFN-beta      bone
                  lsirf, nf-                      http://local   ternary       treatment     marrow,
                  em5,                            host/cgi-      complex       binds to      spleen,
                  IRF4,                           bin/biobas     PU.1/IRF-     DNA only      thymus,
                  transcripti                     e/transfac/    4/DNA         when          B-cell
                  onal        mouse,              7.4/bin/get    has been      recruited     lines, T-
                  activator Mus        vertebrate TFProf.cgi     crystallize   by            cell lines
T01412   NF-EM5   pip.        musculus s          ?T01412        d [2]         phosphory     [4]
                                                                alternative
                                                                 splicing
                                                                leads to
                                                                isoform
                                                                MEF-2 [1]
                                                                additional
                                                                isoforms
                                                                are
                                                                RSRFC4
                                                                and           transcripti
                                                                RSRFC9        onal
                                                                [1] aMEF-     activator     cardiac,
                                                 http://local   2 exhibits    [1]           smooth,
                                                 host/cgi-      a higher      induced       skeletal
                                                 bin/biobas     DNA-          by MyoD,      muscle;
                                                 e/transfac/    binding       involved      placenta,
                           human,                7.4/bin/get    affinity      in            brain,
                           Homo       vertebrate TFProf.cgi     than MEF-     myogenes      lung,
T01006   aMEF-2   aMEF2.   sapiens    s          ?T01006        2 [1]         is            kidney


                                                http://local
                                                host/cgi-
                                                bin/biobas
                           rat,                 e/transfac/
                           Rattus               7.4/bin/get
                           norvegicu vertebrate TFProf.cgi                                  (muscle
T01004   MEF-2    MEF-2.   s         s          ?T01004                                     cells)
                                                                          activator
                                                                          [8]
                                                               alternativeinvolved
                                                                splicing  in
                                                               leads to   myogenes
                                                               aMEF-2,    is [8] [6]
                                                               RSRFC4,    cooperate
                                                               RSRFC9     s with
                                                               direct     myogenic
                                                               interactionbHLH
                                                                with      factors
                                                               other      through E-
                                                               myogenic   box for   cardiac,
                                                               factors    gene      smooth,
                                                               (bHLH      activationskeletal
                                                               proteins   in        muscle,
                                                               MyoD,      skeletal  less in
                                                               myogenin,  muscle    placenta,
                                                                MRF4),    cells [7] brain,
                                                               but not    MADS      lung,
                                                               with E2    domain of kidney
                                                               proteins   MEF2A is  [8]; P19
                                                               [7] G2E    both      cells
                                                               mutant     necessary differentiat
                                                               exhibits    and      ed into
                                                               MCM1-      sufficientneurons
                                                http://local   binding    for       or
                                                host/cgi-      specificitybinding toendoderm
                                                bin/biobas     [5]        MyoD [7]  al cells,
                                                e/transfac/    heterodim            undifferen
                                                                          synergistic
                 MEF-2,    human,               7.4/bin/get    erization            tiated
                 MEF-2A,   Homo      vertebrate TFProf.cgi     with MEF- activation P19 cells
T01005   MEF-2   MEF2.     sapiens   s          ?T01005        2D [1]      of       [4]
                                                                   transcripti
                                                     alternative   onal
                                                      splice       activator
                                                     variants      [11]
                                                     have an       cooperate
                                                     insertion     s with
                                                     of 48 AA      MyoD
                                                     after         through
                                                     residue       direct
                                                     86 or a       interaction
                                                     deletion      s and by
                                                     of 32 AA      binding to
                                                     in the C-     either
                                                     terminal      MEF-2
                                                     region        sites or to   very high
                                                     [11]          E-box         levels in
                                                     calculated    elements      skeletal
                                                                   [8]           muscle,
                                                     isoelectric   myogenin-     lower in
                                                      point is     E12           brain,
                                                     pI = 8.65     heterodim     spleen
                                                     [11] binds    ers           [11];
                                                     to MEF-2      synergistic   developin
                                                     sites [11]    ally          g brain
                                                     gene          activate      [9]; P19
                                                     expressio     transcripti   cells
                                      http://local   n in          on in         differentiat
                                      host/cgi-      developin     collaborati   ed into
                                      bin/biobas     g brain       on with       neurons,
                                      e/transfac/    see for       MEF-2C        C2C12
                  mouse,              7.4/bin/get    detailed      [2] in        myotubes
                  Mus      vertebrate TFProf.cgi     informatio    adult         (protein
T01769   MEF-2C   musculus s          ?T01769        n [9]         mice and      level) [7]
                                                             total of
                                                             six MEF-
                                                             2D splice
                                                             variants
                                                             are         cooperate
                                                             known       s with
                                                             depending   MyoD
                                                              in the     through
                                                             presence    direct
                                                             or          interaction
                                                             absence     s and via
                                                             of either   binding to
                MEF2D,                                       exon A, A   either
                MEF-2D,                                      (MEF-       MEF-2-
                MEF2DAB                                      2DA_, -     sites or to
                , MEF-2D                                     2DA _, or   E-box
                isoform                                      -2D0_)      elements
                AB, MEF-                                     and         [1]
                2D (514                       http://local   presence    mediates
                AA form)                      host/cgi-      or          serum
                (mouse),                      bin/biobas     absence     induction
                MEF-2D                        e/transfac/    of exon B   of the c-
                isoform  human,               7.4/bin/get    (MEF-       jun
         MEF-   1a       Homo      vertebrate TFProf.cgi     2D_B or -   promoter
T01770   2DAB   (mouse). sapiens   s          ?T01770        2D_0) [3]   [2]         NULL
                                                               75%
                                                               identical
                                                               to cdc5 of
                                                               Sacharom
                                                               yces
                                                               pombe
                                                               over 223
                                                               amino
                                                               acids
                                                               comprisin
                                                               g the
                                                               DNA           undergoe
                                                               binding       s rapid
                                                               and           nuclear
                                                               nuclear       translocati
                                                               localizatio   on in
                                                               n             response
                                                               domains       to
                                                               [1] N-        stimulatio
                                                               terminal      n with
                                                               DNA           serum [1]
                                                               binding       transcripti
                                                               domain        onal
                                                               related to    regulator
                PCDC5R                                         Myb           of G2
                P, Pombe                                       family        progressio
                Cdc5-                           http://local   transcripti   n and
                related                         host/cgi-      on factors    mitotic
                protein,                        bin/biobas     [1] C-        entry [3]
                cell                            e/transfac/    terminal      transcripti
                division   human,               7.4/bin/get    transactiv    onal
                control    Homo      vertebrate TFProf.cgi     ation         activator
T04728   Cdc5   protein 5. sapiens   s          ?T04728        domain [3]    [2]         NULL

                                                               pI = 8.67
                                                               mouse
                                                               SF-1 and
                                                               ELP
                                                               transcripts
                                                                arise        belongs
                Ad4BP,                                         from the      to small
                NR5A1,                                         same          group of    (Y1,
                steroidoge                                     structural    orphan      adrenocor
                nic factor                     http://local    gene by       nuclear     tical
                1, STF-1,                      host/cgi-       alternative   receptors   tumor;
                fushi                          bin/biobas       promoter     which       MA-10,
                tarazu                         e/transfac/     usage         bind to     Leydig
                factor     mouse,              7.4/bin/get     and 3 -       DNA as      tumor,
                homolog Mus         vertebrate TFProf.cgi      splicing      monomer     alphaT3-
T01147   SF-1   1.         musculus s          ?T01147         [3].          s [1]       1)
                                                               pI = 7.49
                                                               seems to
                                                               be an          belongs
                                                               essential      to small
                                                               transcripti    group of
                                                               onal           orphan
                                                               factor for     nuclear
                                                               steroidoge     receptors
                                                               nesis as       which
                                                               well as        bind to
                                                               for the        DNA as
                                                               developm       monomer
                                                               ent of the     s and
                                                               reproducti     recognize
                                                               ve axis        s
                                                               [4] SF-1       additional
                                                               and the        nucleotide
                Ad4BP,                                         thereby        s
                NR5A1,                                         regulated      upstream
                steroidoge                      http://local   genes          of the
                nic factor                      host/cgi-      are            hexameric
                1, fushi                        bin/biobas     necessary       half-site
                tarazu                          e/transfac/     for male      (most        pituitary
                factor     human,               7.4/bin/get    sexual         often        gonadotro
                homolog Homo         vertebrate TFProf.cgi     differentiat   AGGTCA       pe cells
T02769   SF-1   1.         sapiens   s          ?T02769        ion [3]        motif) [1]   [5]
                                                                      regulates
                                                                      the genes
                                                                      essential
                                                                      for
                                                                      gonadal
                                                                      developm
                                                                      ent and
                                                                      sexual
                                                                      differentiat
                                                                      ion in
                                                                      addition
                Ftz-F1,                                               to the
                Ad4BP,                                                steroidoge
                NR5A1,                          http://local          nic P-450
                STF-1,                          host/cgi-             genes [2]
                fushi                           bin/biobas            sexually
                tarazu     rat,                 e/transfac/           dimorphic
                factor     Rattus               7.4/bin/get           expressio
                homolog    norvegicu vertebrate TFProf.cgi            n pattern
T04002   SF-1   1.         s         s          ?T04002 pI = 7.48     [2]          NULL

                Ad4BP,
                steroidoge
                nic factor                       http://local
                1, STF-1,                        host/cgi-
                fushi                            bin/biobas
                tarazu                           e/transfac/
                factor     cattle,               7.4/bin/get
                homolog Bos           vertebrate TFProf.cgi
T04014   SF-1   1.         taurus     s          ?T04014 pI = 7.82.              NULL

                Ad4BP,
                steroidoge
                nic factor                       http://local
                1, STF-1,                        host/cgi-
                fushi                            bin/biobas
                tarazu                           e/transfac/
                factor     domestic              7.4/bin/get
                homolog pig, Sus      vertebrate TFProf.cgi
T04015   SF-1   1.         scrofa     s          ?T04015 pI = 7.51               NULL
                                                 http://local        probably
                                                 host/cgi-           expressed
                Ftz-F1,                          bin/biobas           in
                Ad4BP,                           e/transfac/         adrenal
                steroidoge chick,                7.4/bin/get         glands,
                nic factor Gallus     vertebrate TFProf.cgi          ovary,
T04016   SF-1   1, STF-1. gallus      s          ?T04016 pI = 7.81   testis [1]


                                                 http://local
                                                 host/cgi-
                Ftz-F1,                          bin/biobas
                Ad4BP,                           e/transfac/
                steroidoge medaka,               7.4/bin/get
                nic factor Oryzias    vertebrate TFProf.cgi
T04017   SF-1   1, STF-1. latipes     s          ?T04017 pI = 8.17   NULL


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                Ad4BP,                           e/transfac/         testis,
                steroidoge frog,                 7.4/bin/get         brain,
                nic factor Rana       vertebrate TFProf.cgi          kidney,
T04018   SF-1   1, STF-1. rugosa      s          ?T04018 pI = 7.82   spleen [1]

                Ftz-F1,
                Ad4BP,
                steroidoge
                nic factor                       http://local
                1, STF-1,                        host/cgi-
                fushi                            bin/biobas
                tarazu       zebra               e/transfac/
                factor       fish,               7.4/bin/get
                homolog      Brachyda vertebrate TFProf.cgi
T04065   SF-1   1, zFF1.     nio rerio s         ?T04065 pI = 8.94   NULL

                Ftz-F1,
                Ad4BP,                           http://local
                STF-1,                           host/cgi-
                fushi                            bin/biobas
                tarazu                           e/transfac/
                factor       turtle,             7.4/bin/get
                homolog      Trachemy vertebrate TFProf.cgi
T04069   SF-1   1.           s scripta s         ?T04069 pI = 8.37   NULL
                                                                            after day
                                                                            10.5, di-
                                                                            and
                                                                            mesencep
                                                                            halon and
                                                                            intestinal
                                                                            epithelium
                                                                             during
                                                                            embryoge
                                                                            nesis [3];
                                                                            embryo:
                                                                            gut
                                                                            epithelium
                                                                            , brain:
                                                                            thalamus
                                                                            and roof
                                                               TCF-4        of
                                                    TCF-4      seems to     midbrain
                                                    has        have an      [1]; adult:
                                                    multiple   important    widesprea
                                                    RNA        function     d
                                                    splice     in the       expressio
                                     http://local   variants   developm     n with
                                     host/cgi-      with       ent of the   high
                                     bin/biobas     diverse    vertebrate   levels in
                                     e/transfac/    sequence                liver and
                 mouse,              7.4/bin/get    s 3´ to    gastrointe   gastrointe
                 Mus      vertebrate TFProf.cgi     the HMG    stinal       stinal
T02915   TCF-4   musculus s          ?T02915        box [1]    tract [1]    tract [1]
                                                               2 splice      TCF-
                                                               variants      4/beta-
                                                               TCF-4B        Catenin-
                                                               <T02917>      complex
                                                                and TCF-     activates
                                                               4E            transcripti
                                                               <T02878>      on of
                                                                [9] TCF-     target
                                                               4 is an       genes [2]
                                                               element       [9] in the
                                                               of the        absence
                                                               Wingless-     of beta-
                                                               Wnt           Catenin
                                                               signaling     TCF acts
                                                               cascade:      as a
                                                               the           negative
                                                               presence      regulator
                                                               of a Wnt-     of
                                                               signal        transcripti
                                                               inhibits      on [3] cell
                                                               the           lines CD-
                                                               activity of   NCM425
                                                               glycogen      and
                                                               synthase      CC07
                                                               kinase-       express
                                                               3beta         high level
                 hTCF-4,                        http://local   (GSK3bet      of TCF-4,
                 human                          host/cgi-      a) which      after beta-
                 TCF-4,                         bin/biobas     in turn       catenin
                 transcripti                    e/transfac/    does not      transfectio
                 on factor- human,              7.4/bin/get    phosphory     n the
                 7-like-2,   Homo    vertebrate TFProf.cgi     late beta-    expressio
T02918   TCF-4   TCF7L2. sapiens     s          ?T02918        Catenin       n of the    NULL
                                                                   high
                                                                   homology
                                                                   to human
                                                                   and
                                                                   murine
                                                                   TCF-4, C-    serves as
                                                                   terminus     nuclear
                                                                   reveals      transduce
                                                                   homology     r of the
                                                                   to splice    Wnt-/Wg
                                                                   variants     signaling
                                                                   TCF-4B       cascade,
                                                                   and TCF-     upon wnt-
                                                                   4E, RT-      / wg
                                                                   PCR          signaling
                                                                   analysis     TCF-4        anterior
                                                                   showed       interacts    part of
                                                                   that         with beta-   the
                                                    http://local   expressio    catenin      midbrain
                                                    host/cgi-      n of TCF-    and          (shown
                 Xenopus                            bin/biobas     4 starts     regulates    by whole-
                 laevis T-     clawed               e/transfac/    from late    expressio    mount in
                 cell factor   frog,                7.4/bin/get    neurula      n of         situ
                 4, T cell     Xenopus   vertebrate TFProf.cgi     stages       target       hybridisati
T03404   TCF-4   factor 4.     laevis    s          ?T03404        onward [1]   genes [1]    on) [1]


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                 EF-C, RF- rat,                  e/transfac/
                 X,         Rattus               7.4/bin/get
                 regulatory norvegicu vertebrate TFProf.cgi
T00229   RFX1    factor X1. s         s          ?T00229                                     (liver)
                                                                 monomeri
                                                                 c DNA-
                                                                 binding,
                                                                 spanning
                                                                 about 20
                                                                 nucleotide
                                                                 s of one
                                                                 face of
                                                                 the DNA
                                                                 double
                                                                 helix [5]
                                                                 [6] major
                                                                 groove       may play
                                                                 contacts     an
                                                                 within the   important
                                                                 contact      role in
                                                                 core         mesoder
                                                                 region,      mal cell
                                                                 minor        developm
                                                                 groove       ent for
                                                                 binding in   organ
                                                                 the          formation
                                                                 flanking     and
                                                                 sequence     tissue
                                                                 s [5] may    modeling   T-cells
                                                                 be part of   [1]        (predom.);
                                                  http://local   complex      mitogenic   lymphoid
                                                  host/cgi-      arrays of    stimuli    cells:
                                                  bin/biobas     factor       cause Ca-  thymocyte
                                                  e/transfac/    binding      dependent  s, bursal
                              mouse,              7.4/bin/get    sites, e.               lymphocyt
                   c-Ets-1,   Mus      vertebrate TFProf.cgi     g. along     phosphory es (all cell
T00111   c-Ets-1   Ets1, p54. musculus s          ?T00111        with         lation [9] lines) [1]
                                                                                 activator
                                                                                 functional
                                                                                 cooperatio
                                                                                 n with AP-
                                                                                 1 [8] [6]
                                                                                 and Sp1
                                                                                 [2] in
                                                                                 some
                                                                                 cases,
                                                                                 repression
                                                                                  of AP-1
                                                                   negative      effects
                                                                   net           have
                                                                   charge (-     been
                                                                   10) of the    reported
                                                                   trans-        as well      T-cells
                                                    http://local   activation    which        (predom.);
                    c-Ets-1, c-                     host/cgi-      domain        depends       lymphoid
                    Ets-1 54,                       bin/biobas     [4]           on the C-    cells [10]:
                    Ets1,                           e/transfac/    phosphory     terminal     thymocyte
                    p54,        chick,              7.4/bin/get    lation (Ca-   repressing   s, bursal
                    p54c-Ets- Gallus     vertebrate TFProf.cgi     dependent      domain      lymphocyt
T00114   c-Ets-1 54 1.          gallus   s          ?T00114        ) [9]         [1]          es [10]
                                                                               activator
                                                                 alternative   [8] [4] [6]
                                                                  splice       stronger
                                                                 variant: c-   activator
                                                                 Ets-1 54,     than p54
                                                                 differing     splice
                                                                 in the N-     variant [4]
                                                                 termini in    functional
                                                                 addition      cooperatio
                                                                 to the        n with AP-
                                                                 mid-          1 at some
                                                                 regional      promoters
                                                                 represing      [8] [4]
                                                                 domain,       levels
                                                                 the C-        decrease
                                                                 terminal      after T
                                                                 part of       cell
                                                                 the           induction
                                                                 molecule      associatio
                                                                 also          n with
                                                                 inhibits      MafB
                                                  http://local   DNA-          <T01433>       T-cells
                                                  host/cgi-      binding        causes        (predom.);
                                                  bin/biobas     [2]           inhibition
                                                  e/transfac/    phosphory     of             thymocyte
                    c-Ets-1   chick,              7.4/bin/get    lation (Ca-   erythroid      s, bursal
                    68, p68c- Gallus   vertebrate TFProf.cgi     dependent     differentiat   lymphocyt
T00115   c-Ets-1 68 Ets-1.    gallus   s          ?T00115        ) [9]         ion [1]        es [10]



                                                                               cooperativ
                                                                               e binding
                                                                 1H NMR:       to several
                                                                 2 zinc        widely
                                                                 ions          spaced
                                                                 coordinate    half-sites
                                                                 d by 4        [2]
                                                                 Cys           cooperativ
                                                  http://local   within        e effects
                                                  host/cgi-      each zinc     with AP-1
                                                  bin/biobas     finger 2      do not
                  ER,                             e/transfac/    perpendic     require
                  estrogen    chick,              7.4/bin/get    ular alpha-   DNA-
                  receptor,   Gallus   vertebrate TFProf.cgi     helices       binding
T00264   ER-alpha NR3A1.      gallus   s          ?T00264        [5] [1]       by ER [3] NULL
                                                              86%           (E15.5:)
                                                              amino         skeletal
                                                              acid          muscle,
                                                              identity to   (adult:)
                                                              human         skeletal
                                               http://local   FOXO4         muscle,
                                               host/cgi-      <T03403>      heart,
                                               bin/biobas     , 96%         brown
                                               e/transfac/    identity      and white
                 AFX,      mouse,              7.4/bin/get    within the    adipose
                 AFX-1,    Mus      vertebrate TFProf.cgi     fork head     tissues
T04176   FOXO4   AFXH.     musculus s          ?T04176        domain [1]    [2] [1]

                                                                            (cell
                                                                            lines:) ES
                                                                            cells,
                                                                            (embryo:)
                                                                            metaneph
                                                                            ros,
                                                                            glomeruli,
                                                                            liver,
                                                                            stomach,
                                                              expressed     submand.
                                                               in many      gland
                                                              tissues       acini,
                                                              but not all   spinal
                                                              cell types    ganglia,
                                                              [1] very      chondrocy
                                                              early         tes, lung
                                                              erpressed     and lens
                                                               in 8-16      epithelium
                                                              cell          ,
                                                              embryos       vibrissae
                                                              and both      follicles,
                                                              layers of     (adult:)
                                                              blastocyst    brain,
                                                              s [1]         heart,
                                              http://local    expressio     skel.
                 FHX.L,                       host/cgi-       n             muscle,
                 fork head                    bin/biobas      activated     ovary,
                 homologo                     e/transfac/     during        lung,
                 us X,     mouse,             7.4/bin/get     spermato      kidney,
                 long      Mus     vertebrate TFProf.cgi      genesis       testes,
T04170   FOXJ2   isoform. musculus s          ?T04170         [1]           uterus [1]
                                                     http://local
                                                     host/cgi-      full length
                                                     bin/biobas     sequence
                                                     e/transfac/    has not
                          human,                     7.4/bin/get    been                       none
                  FKHL11, Homo            vertebrate TFProf.cgi     identified                 detected
T02475   FOXL1    FREAC7. sapiens         s          ?T02475        so far [2]                 so far [2]


                                                     http://local
                                                     host/cgi-
                                                     bin/biobas
                                                     e/transfac/
                  glial cells   human,               7.4/bin/get
                  missing       Homo      vertebrate TFProf.cgi
T02306   GCMa     factor a.     sapiens   s          ?T02306                                   NULL


                                                    http://local
                                                    host/cgi-
                                                    bin/biobas
                                                    e/transfac/
                  glial cells   mouse,              7.4/bin/get
                  missing       Mus      vertebrate TFProf.cgi
T02307   GCMa     factor a.     musculus s          ?T02307                                    NULL


                                                    http://local
                                                    host/cgi-
                                                    bin/biobas
                                                    e/transfac/
                  glial cells   mouse,              7.4/bin/get
                  missing       Mus      vertebrate TFProf.cgi
T02308   GCMb     factor a.     musculus s          ?T02308                                    NULL
                                                                                  activator,
                                                                                  mediates
                                                                                  Ras- or
                                                                                  Raf-         heart,
                                                     http://local                 response     kidney,
                                                     host/cgi-                    through      liver,
                  Ras-                               bin/biobas                   Ras-         lung,
                  responsiv                          e/transfac/                  responsiv    pancreas,
                  e element human,                   7.4/bin/get                  e            placenta,
                  binding    Homo         vertebrate TFProf.cgi                   elements     skeletal
T01975   RREB-1   protein 1. sapiens      s          ?T01975                      (RRE) [1]    muscle [1]
                                       http://local
                                       host/cgi-
                                       bin/biobas
                  rat,                 e/transfac/
                  Rattus               7.4/bin/get
                  norvegicu vertebrate TFProf.cgi
T03882   SMAD-4   s         s          ?T03882         NULL


                                      http://local
                                      host/cgi-
                                      bin/biobas
                  zebra               e/transfac/
                  fish,               7.4/bin/get
                  Brachyda vertebrate TFProf.cgi
T03884   SMAD-4   nio rerio s         ?T03884          NULL


                                        http://local
                                        host/cgi-
                                        bin/biobas
                                        e/transfac/
                  domestic              7.4/bin/get
                  pig, Sus   vertebrate TFProf.cgi
T04252   SMAD-4   scrofa     s          ?T04252        NULL
                                                                structure    nuclear
                                                                of CTD       translocati
                                                                (C-          on
                                                                terminal     depends
                                                                domain       on
                                                                or MH2       receptor
                                                                domain)      activated
                                                                consists     SMADs,
                                                                of a beta-   like
                                                                sandwich     SMAD-1
                                                                with a       or SMAD-
                                                                three-       2 in
                                                                helix        response
                                                                bundle on    to BMP4
                                                                one end      or TGF-
                                                                and a        beta [13]
                                                                collection   it is
                                                                of three     surmised
                                                                large        that
                                                                loops and    activated
                                                                an alpha-    SMADs
                                                                helix on     bind
                                                                the other    SMAD-4
                                                                [12] CTD     in the
                                                                contains     cytoplasm
                                                                a primary     and carry
                                                 http://local   homo-        it into the
                                                 host/cgi-      oligomeriz   nucleus
                  DPC4                           bin/biobas     ation        [13]
                  (Deleted                       e/transfac/    activity     forms a
                  in         human,              7.4/bin/get    [12] a       ternary
                  pancreatic Homo     vertebrate TFProf.cgi     model of     complex
T04292   SMAD-4    cancer). sapiens   s          ?T04292        hetero-      with        NULL


                                                http://local
                                                host/cgi-
                                                bin/biobas
                                                e/transfac/
                            mouse,              7.4/bin/get
                            Mus      vertebrate TFProf.cgi
T05067   SMAD-4             musculus s          ?T05067                                NULL
                                                                    homeo         required
                                                                    domain is     for
                                                                    most          thyroid-
                                                                    closely       specific
                                                                    related to    gene
                                                                    that of       expressio
                                                                    NK-2          n [12]
                                                                    (82%          DNA-
                                                                    identity)     binding
                                                                    [12] DNA-     capability
                                                                    binding       may be
                                                                    specificity   regulated
                                                                    is            through
                                                                    determine     oxidation
                                                                    d by the      of Cys-87
                                                                    recognitio    and Cys-
                                                                    n helix       363 [1]
                                                                    plus          expressed
                                                                    additional     at the
                                                                    parts of      earliest
                                                                    the HD        stages of
                                                                    [10]          differentiat
                                                                    essential     ion of
                                                                    for TTF-1     thyroid
                 T/EBP,                                             binding to    and lung
                 TTF-1,                                             CAAG          tissue
                 thyroid                            http://local    instead of    [11] in the
                 transcripti                        host/cgi-       TAAT as       lung, it is
                 on factor                          bin/biobas      most          confined
                 1, thyroid    rat,                 e/transfac/     other HD      to
                 nuclear       Rattus               7.4/bin/get     factors is    bronchial
                 factor 1,     norvegicu vertebrate TFProf.cgi      Gln-210       epithelium thyroid,
T00856   TTF-1   Titf1.        s         s          ?T00856         [3] three-     at later    lung [12]

                 T/EBP,                                             strong
                 TTF-1,                                             homology
                 thyroid                                            ( 98%) to                   thyroid
                 transcripti                                        the           plays an      gland
                 on factor                                          mouse         important     epithelium
                 1, thyroid                                         TTF-1         role in the   ; lung
                 nuclear                             http://local   with          regulation    (alveolar
                 factor 1,                           host/cgi-      absolute      of lung       type II
                 thyroid-                            bin/biobas     conservati    developm      cells and
                 specific                            e/transfac/    on of the     ent and       bronchiola
                 enhancer- human,                    7.4/bin/get    60 AA         surfactant    r
                 binding     Homo         vertebrate TFProf.cgi     homeodo       homeosta      epithelial
T00857   TTF-1   protein.    sapiens      s          ?T00857        main [1]      sis [4]       cells) [4]
                                                                            expressio
                                                                            n in the
                                                                            neural
                                                 http://local               plate
                                                 host/cgi-                  (embryon
                                                 bin/biobas                 al) is
                                                 e/transfac/                induced
                            chick,               7.4/bin/get                by sonic
                            Gallus    vertebrate TFProf.cgi                 hedgehog thyroid
T00858   TTF-1   TTF-1.     gallus    s          ?T00858                    (Shh) [1]. cells, lung
                                                                expressio
                                                                n in the
                                                                neural
                                                http://local    plate
                                                host/cgi-       (embryon
                                                bin/biobas      al) is                 (embryoni
                 T/EBP,                         e/transfac/     induced                c) neural
                 TTF-1,     mouse,              7.4/bin/get     by sonic               plate [3];
                 Nkx2.1,    Mus      vertebrate TFProf.cgi      hedgehog               thyroid
T00859   TTF-1   Nkx-2.1.   musculus s          ?T00859         (Shh) [2]              cells, lung


                                                 http://local
                                                 host/cgi-
                                                 bin/biobas
                                                 e/transfac/
                            cattle,              7.4/bin/get
                            Bos       vertebrate TFProf.cgi                            (thyroid
T01518   TTF-1              taurus    s          ?T01518                               cells)


                 TTF-1,                          http://local
                 thyroid                         host/cgi-
                 transcripti                     bin/biobas
                 on factor                       e/transfac/
                 1, thyroid dog,                 7.4/bin/get
                 nuclear     Canis    vertebrate TFProf.cgi
T02098   TTF-1   factor 1. canis      s          ?T02098                               NULL
                                                                    transcripti
                                                                    onal
                                                                    activator
                                                                    [13] [7]
                                                                    [12] [2]
                                                                    oncogene,

                                                                       transform
                                                                       s myeloid
                                                                       and
                                                                       (weakly)
                                                                       erythroid
                                                                       cells [11]
                                                                       difference
                                                                       s
                                                                       between
                                                                       the
                                                                       second
                                                                       DNA-
                                                                       binding
                                                            the DNA- repeats
                                                            binding    of E26
                                                            domain     and AMV
                                                            resides in cause
                                                            the N-     different
                                                            terminal   phenotype
                                               http://local part [16] s of
                                               host/cgi- and           transform
                                               bin/biobas interacts ed cells
                          AMV,                 e/transfac/ with the    [11] lacks
                          avian                7.4/bin/get DBD of      the
                          myeloblas vertebrate TFProf.cgi C/EBPbet regulatory
T00895   v-Myb   v-Myb.   tosis virus s        ?T00895 a [3]           phosphory NULL
                                                                                         embryonic
                                                                                          anterior
                                                                                         pituitary;
                                                                                         adult
                                                                                         hippocam
                                                                                         pus,
                                                                                         ventrome
                                                                            activator    dial
                                                                            in the       nucleus
                                                                            developin    of
                                                                            g            hypothala
                                                                            thyrotroph   mus,
                                                                             [3]         piriform
                                                                            expressio    cotrex,
                                                                            n varies     medial
                                                                            with         nucleus
                                                                            circadian    of the
                                                                            rhythm       amygdala;
                                                                            exhibiting    3 week:
                                                                            maximum      brain,
                                                                            levels in    heart,
                                                                            the          spleen;
                                                                            evening      21 week:
                                              http://local                  and          lung,
                                              host/cgi-                     minimum      kidney,
               TEF,                           bin/biobas                    levels in    muscle,
               thyrotroph rat,                e/transfac/                   the          liver,
                          Rattus              7.4/bin/get                   morning      heart,
               embryonic norvegicu vertebrate TFProf.cgi                    similarly    spleen,
T01072   TEF    factor.   s        s          ?T01072                       to DBP [1]   brain



                                                              TEF
                                                              bound
                                                              preferenti
                                                              ally to the
                                                              consensu
                                               http://local   s
                                               host/cgi-      sequence
                                               bin/biobas     GTTACG                     lung,
               Thyrotrop                       e/transfac/    TAAT(bin                   liver,
               h         human,                7.4/bin/get    ding site                  spleen,
               Embryonic Homo       vertebrate TFProf.cgi     selection                  and
T04876   TEF    Factor.  sapiens    s          ?T04876        assay) [1]                 kidney [2]
                                                    http://local
                  IgNF-A,                           host/cgi-
                  NF-A, NF-                         bin/biobas
                  A1, NF-                           e/transfac/
                  A2, oct-  human,                  7.4/bin/get
                  B1A, oct- Homo         vertebrate TFProf.cgi
T00545   NF-A     B1B.      sapiens      s          ?T00545        NULL


                                                   http://local
                  IgNF-A,                          host/cgi-
                  NF-A, NF-                        bin/biobas
                  A1, NF-     monkey,              e/transfac/
                  A2, oct-    Cercopith            7.4/bin/get
                  B1A, oct-   ecus      vertebrate TFProf.cgi
T01191   NF-A     B1B.        aethiops s           ?T01191         NULL


                                                http://local
                  IgNF-A,                       host/cgi-
                  NF-A, NF-                     bin/biobas
                  A1, NF-                       e/transfac/
                  A2, oct-  mouse,              7.4/bin/get
                  B1A, oct- Mus      vertebrate TFProf.cgi
T01192   NF-A     B1B.      musculus s          ?T01192            NULL


                                                    http://local
                                                    host/cgi-
                  B2                                bin/biobas
                  octamer                           e/transfac/
                  binding     human,                7.4/bin/get    (B cells,
                  factor,     Homo       vertebrate TFProf.cgi     BJA-B,
T00663   oct-B2   oct-B2.     sapiens    s          ?T00663        MOLT-4)


                                                    http://local
                                                    host/cgi-
                                                    bin/biobas
                                                    e/transfac/    (HeLa,BJ
                              human,                7.4/bin/get    A-
                              Homo       vertebrate TFProf.cgi     B,MOLT-
T00664   oct-B3   oct-B3.     sapiens    s          ?T00664        4)
                                                                 two Oct-2     activator
                                                                 sequence      [38],
                                                                 s             actively
                                                                 differring    supporting
                                                                 in the 16
                                                                 AA            assembly
                                                                 stretch at    of basal
                                                                 168-183       transcripti
                                                                 may           on
                                                                 represent     complex
                                                                 splice        [8] has to
                                                                 variants      be
                                                                 [40] [41],    present
                                                                 a third       for many
                                                                 one is        rounds of
                                                                 Oct-2B        transcripti
                                                                 bipartite     on [8]
                                                                 DNA-          expressed
                                                                 binding         in CD4+,
                                                                 domain        but not in
                                                                 with          CD8+ T
                                                                 POUs          cells
                                                                 and           enhanced
                                                                 POUh          by
                                                                 domain        ionomycin
                                                                 [36] [6]      ,
                  IgNF-A,                         http://local   three Oct-    ionomycin
                  NF-A, NF-                       host/cgi-      2A-             + PMA,
                  A2, NF-                         bin/biobas     related       or antigen
                  III, Oct-2,                     e/transfac/    peptides      [9] down-
                  Oct-2A,     human,              7.4/bin/get    in B cells    regulated
                  OTF-2,      Homo     vertebrate TFProf.cgi     [45]          by IFN-     lymphoid
T00647   POU2F2   OTF-2A. sapiens      s          ?T00647        interacting   alpha or cells
                                                                    at least
                                                                    six splice
                                                                    variants
                                                                    known:
                                                                    Oct-2.1,
                                                                    Oct-2/Oct-
                                                                    2A/Oct-
                                                                    2.2, Oct-
                                                                    2.3, Oct-
                                                                    2.4, Oct-
                                                                    2B/Oct-
                                                                    2.5, and
                                                                    Oct-2.6
                                                                    [4] the
                                                                    glutamine-
                                                                    rich
                                                                    region
                                                                    acts as
                                                                    trans-
                                                                    activation
                                                                    domain
                                                                    through
                                                                    proximal
                                                                    octamer
                                                                    elements               B cells,
                  IgNF-A,                                           exclusivel             induced
                  NF-A, NF-                       http://local      y [1] the              pre-B
                  A2, NF-                         host/cgi-         C-                     cells;
                  III, Oct-2,                     bin/biobas        terminal,              brain,
                  Oct-2A,                         e/transfac/       proline-               kidney;
                  OTF-2,      mouse,              7.4/bin/get       rich trans-            sperm;
                  OTF-2A, Mus          vertebrate TFProf.cgi        activation activator   12d
T00648   POU2F2   Oct-2.2.    musculus s          ?T00648           domain      [1]        embryo


                                                     http://local                          lymphoid
                                                     host/cgi-                             cells,
                                                     bin/biobas                            intestine,
                                                     e/transfac/                           testis,
                                                     7.4/bin/get                           kidney,
                             cat, Felis   vertebrate TFProf.cgi                            nervous
T00649   POU2F2   Oct-2.     catus        s          ?T00649                               system
                                                                                          lymphoid
                                                                                          cells,
                                                                                          intestine,
                                                                                          testis,
                                                                                          kidney,
                                                                                          nervous
                                                                                          system,
                                                                                          here in
                                                                                          suprachia
                                                                                          smatic
                                                                                          and
                                                                                          medial
                                                                    the four              mammillar
                                                                    known                 y nuclei
                                                                    splice                of
                                                                    variants              hypothala
                                                                    (Oct-2.1,             mus,
                                                                    Oct-                  granule
                                                                    2/Oct2A/O             and red
                                                                    ct-2.2,               nucleus
                                                                    Oct-2.7,              (adults),
                                                     http://local   and Oct-              widesprea
                                                     host/cgi-      2.8) differ up-       d
                                                     bin/biobas     in their    regulated expressio
                                                     e/transfac/    DNA-        by nerve n in
                     Oct-2,     rat,                 7.4/bin/get    binding     growth    emrbyonal
                     Oct-2A,    Rattus    vertebrate TFProf.cgi     specificity factor     nervous
T00650   POU2F2      Oct-2.2.   rattus    s          ?T00650        [2]         (NGF) [1] system [3]


                     IgNF-A,                         http://local
                     NF-A, NF-                       host/cgi-
                     A2, NF-                         bin/biobas
                     III, Oct-2,                     e/transfac/
                     Oct-2A,     chick,              7.4/bin/get
                     OTF-2,      Gallus   vertebrate TFProf.cgi
T01032   POU2F2      OTF-2A. gallus       s          ?T01032                             NULL


                                                     http://local
                                                     host/cgi-
                                                     bin/biobas
                                                     e/transfac/
                                human,               7.4/bin/get
         POU2F2                 Homo      vertebrate TFProf.cgi
T00646   (Oct-2.1)              sapiens   s          ?T00646                             NULL
                                                http://local
                                                host/cgi-
                                                bin/biobas
                                                e/transfac/
                 Oct-2B,    human,              7.4/bin/get
                 OTF-2B,    Homo     vertebrate TFProf.cgi                              lymphoid
T00662   POU2F2B Oct-2.5.   sapiens  s          ?T00662 at least                        cells
                                                             six splice
                                                             variants
                                                             known:
                                                             Oct-2.1,
                                                             Oct-2/Oct-
                                                             2A/Oct-
                                                             2.2, Oct-
                                                             2.3, Oct-
                                                             2.4, Oct-
                                                             2B/Oct-
                                                             2.5, and      higher
                                                             Oct-2.6       levels of
                                                             [4] the       Oct-2B
                                                             glutamine-    than of
                                                             rich trans-   Oct-2 in
                                                             activation    brain,
                                                             domain        testis,
                                                             which         and 12d
                                                             acts          embryo,
                                                             through       equal
                                                             proximal      concentrat
                                                             octamer       ions of      B cells,
                                                             elements      both         induced
                                                             exclusivel    isoforms     pre-B
                                                             y is N-       in kidney,   cells,
                                                http://local terminally    less Oct-    lower
                                                host/cgi- truncated        2B than      levels in
                                                bin/biobas [1] the C-      Oct-2 in     brain,
                                                e/transfac/ terminal,      B cells      kidney,
                 Oct-2B,    mouse,              7.4/bin/get proline-       and          sperm;
                 OTF-2B,    Mus      vertebrate TFProf.cgi rich trans-     intestine    12d
T00964   POU2F2B Oct-2.5.   musculus s          ?T00964 activation         [5]          embryos


                                                  http://local
                                                  host/cgi-
                                                  bin/biobas
                                                  e/transfac/
                            human,                7.4/bin/get
                            Homo       vertebrate TFProf.cgi
T00665   POU2F2C Oct-2C.    sapiens    s          ?T00665                               B-cells
                                                                                involved
                                                                                in liver-
                                                                                specific
                                                                                gene
                                                                                expressio
                                                                                n inhibits
                                                                                HNF-1
                                                                                action on
                                                                                aldolaseB
                                                                                promotor
                                                                                [3] RA
                                                                                induces
                                                                                transcripti
                                                                                on [4]
                                                  http://local                  probably
                                                  host/cgi-                     involved
                  HNF3,                           bin/biobas                    in some
                  HNF-3A,    rat,                 e/transfac/                   steroid
                  HNF-       Rattus               7.4/bin/get                   hormone liver
         HNF-     3alpha,    norvegicu vertebrate TFProf.cgi                    regulatory (intestine,
T00371   3alpha   HNF-5.     s         s          ?T00371                       circuits [2] lung)
                                                                                             (adult)
                                                                                             pullmonar
                                                                                             y (NCI-
                                                                                             H441,
                                                                                             Ishikawa,
                                                                                             A549),
                                                                                             hepatic
                                                   http://local                              (HepG2),
                                                   host/cgi-                                 and
                  Hepatocyt                        bin/biobas                                breast
                  e Nuclear                        e/transfac/                               (MCF-7
                  Factor 3 human,                  7.4/bin/get                               and
         HNF-     alpha,    Homo        vertebrate TFProf.cgi                                MD468)ce
T02512   3alpha   HNF3A.    sapiens     s          ?T02512                                   ll lines

                                                                  usage of
                                                                  downstrea
                                                                  m
                                                                  translation
                                                                   initiation
                                                                  codons
                                                   http://local   gives rise               nervous
                                                   host/cgi-      to N-Oct-                system
                                                   bin/biobas     5a                       [1], small
                                                   e/transfac/    <T00632>                 cell lung
                  N-Oct-3,   human,                7.4/bin/get     and -b                  cancer
                  Brn-2,     Homo       vertebrate TFProf.cgi     <T00633>                 (SCLC)
T00630   POU3F2   Brain-2.   sapiens    s          ?T00630         [1]                     cells [2]
                                                                          transcripti   brain,
                                                                          onal          hypothala
                                                                          activator     mus:
                                                                          N-Oct-        dorsomedi
                                                                          3/Brn-2       al
                                                                          expressio     paracellul
                                                                          n within      ar region
                                                                          the           of the
                                                                          hypothala     paraventri
                                                                          mus           cular
                                                                          colocalize    nucleus,
                                                               binding to s with        medial
                                                  http://local CAT and expressio        and
                                                  host/cgi- TAAT          n of CRH      lateral
                                                  bin/biobas half-sites (corticotro     posterior
                              rat,                e/transfac/ with 0, 2, pin-           magnocell
                  N-Oct-3, Rattus                 7.4/bin/get or 3 nt     releasing     ular
                  Brn2, Brn- norvegicu vertebrate TFProf.cgi spacing      hormone)      neurons
T01524   POU3F2   2, Brain-2. s        s          ?T01524 [1]             [1]           [1]

                                                                          mediates
                                                                          response
                                                                          to several
                                                                          cytokines
                                                                          and
                  MGF,                                                    hormones
                  signal                                                  , in
                  transduce                                               particular
                  r and                                                   to
                  activator                                               prolactin
                  of                              http://local            [3] [1] [2]
                  transcripti                     host/cgi-               phosphory
                  on 5 A,                         bin/biobas              lation of     high in
                  mammary                         e/transfac/             Tyr-694       lactating
                   gland                          7.4/bin/get             most          mammary
                  factor,     sheep,   vertebrate TFProf.cgi              likely by      gland [3]
T01578   STAT5A   STF-IL-3. Ovis aries s          ?T01578                 Jak2 [2]      [1] [2]
                                                                              mediates
                                                                              response
                                                                              to several
                                                                              cytokines
                                                                              and
                                                                              hormones
                  MGF,                                                        , in          high in
                  signal                                                      particular    lactating
                  transduce                                                   to IL-2       mammary
                  r and                                                       [2], IL-5      gland,
                  activator                                       highly      [4], GM-      thymus
                  of                            http://local      related to CSF [4],       spleen;
                  transcripti                   host/cgi-         STAT5B, erythropoi        moderate
                  on 5 A,                       bin/biobas        but         etin [2] is   in bone
                  mammary                       e/transfac/       encoded activated         marrow,
                   gland      mouse,            7.4/bin/get       by a        by IL-10      heart,
                  factor,     Mus    vertebrate TFProf.cgi        different and IL-3        kidney,
T01579   STAT5A   STF-IL-3. musculus s          ?T01579           gene [4] [1]
                                                                  binds as                  lung [3] [4]
                                                                  homodime
                                                                  r and
                                                                  homotetra
                                                                  mer to
                                                                  consensu
                                                                  s GAS
                                                                  (interferon
                                                                   gamma-
                                                                  activated
                                                                  sequence
                                                                  s) motifs
                                                                  TTC(T/C)
                                                                  N(G/A)GA
                                                                  A [1]
                                                                  STAT5A
                                                                  tetramers
                                                                  bind to
                                                                  two
                                                                  tandem
                                                                  repeated
                                                                  GAS
                                                                  sites with
                                                                  an
                                                                  optimal
                                                                  spacing
                  signal                           http://local   of 6 bp
                  transduce                        host/cgi-      [1]
                  r and                            bin/biobas     STAT5A
                  activator                        e/transfac/    binds to
                  of          human,               7.4/bin/get    the beta-
                  transcripti Homo      vertebrate TFProf.cgi     casein
T04683   STAT5A   on 5a.      sapiens   s          ?T04683        promoter                  NULL
                                                                            modest
                                                                            activator
                                                                            [7]
                                                                            probably
                                                                            important
                                                                            for
                                                                            myocard
                                                                            developm
                                                                            ent [1]
                                                                            expressio
                                                                            n first
                                                                            detected
                                                                            in
                                                                            myocardio
                                                               at least     genic
                                                               two          progenitor
                                                               different     cells
                                                               consensu     during
                                                               s binding    early         (cell
                                                               sequence     headfold      lines).
                                                               s [7] the    stages,       Fibroblast:
                                                               potent       then           NIH3T3;
                                                               trans-       maintaine     Bone
                                                               activation   d in          marrow
                                                               domain is    cardiomyo     stroma:
                                                               maked by     cytes of      BAd;
                                                http://local   the          embryonic     Thymic
                  Csx, Nkx-                     host/cgi-      alanine-     , fetal and   stroma:
                  2.5,                          bin/biobas     and          adult         SCL-19;
                  cardiac-                      e/transfac/    proline-     heart [1]     Lymph
                  specific  mouse,              7.4/bin/get    rich C-      also          node
                  homeobox Mus       vertebrate TFProf.cgi     terminus     expressed     stroma:
T01675   Nkx2-5    protein. musculus s          ?T01675        [7]           in           TSL-1 [1]
                                                               in
                                                               colestipol-
                                                               treated
                                                               hamster
                                                               livers, the
                                                               amount
                                                               of
                                                               membran
                                                               e-bound
                                                               precursor
                                                               form is
                                                               unchange
                                                               d after
                                                               treatment
                                                               with
                                                               increasing
                                                                amounts
                                                               of
                                                               mevinolin
                                                               (7d)
                                                               whereas
                                                               the
                                                               mature
                                                               form in
                                                http://local   the
                                                host/cgi-      nucleus
                                                bin/biobas     decreases
                                                e/transfac/     (contrast
                          hamster,              7.4/bin/get    to
                 SREBP-   Cricetulus vertebrate TFProf.cgi     SREBP-
T01559   SREBP-1 1a.       griseus   s          ?T01559        2) [1]      NULL
                                                                       transcripti
                                                                       onal
                                                                       activator,
                                                                       acting
                                                                       through
                                                                       some E-
                                                                       box
                                                                       elements
                                                                       (carbohyd
                                                                       rate
                                                                       response
                                                                       element)
                                                                       [2] [1], but
                                                                       also
                                                                       through        highest
                                                                       sterol-        expressio
                                                                       regulatory     n in
                                                                       element-       brown
                                                                       1 (SRE-        adipose
                                                                       1) [1] may     tissue,
                                                                       play an        low levels
                                                                       important      in
                                                                       role in        intestine,
                                                                       controlling    spleen,
                                                                                      skeletal
                                                                      determina       muscle,
                                              http://local the dual   tion- and       thymus;
                                              host/cgi- DNA-          differentiat    nearly
                                              bin/biobas binding      ion-linked      undetecta
                         rat,                 e/transfac/ specificity gene            ble in
                         Rattus               7.4/bin/get is due to expressio         brain,
                         norvegicu vertebrate TFProf.cgi Tyr-305      n in            heart,
T01562   SREBP-1 ADD1.   s         s          ?T01562 [1]             adipocyte       testis [2]
                                                                only zinc      suppresse
                                                                finger 2       s
                                                                plus an        myelomon
                                                                adjacent       ocytic
                                                                basic          differentiat
                                                                region is      ion [2]
                                                                required       high
                                                                for DNA-       levels of
                                                                binding        GATA-1
                                                                [10] [7] [5]   in
                                                                [3] DNA        myeloblas
                                                                binding        ts
                                                                requires       correlate
                                                                zinc (or       with
                                                                other          reprogram
                                                                heavy          ming to
                                                                metal          thrombobl
                                                                ions) [7]      ast
                                                                zinc           phenotype
                                                                finger 1       ,
                                                                contribute     intermedia
                                                                s strongly     te levels
                                                                to the         with
                                                                stability of   eosinophil
                                                                DNA
                                                                binding at     phenotype
                  EF1,                           http://local   some            [2] at
                  EFgamma                        host/cgi-      particular     least in       erythroid
                  a, Eryf-1,                     bin/biobas     sites          certain        cells,
                  GF-1, NF-                      e/transfac/    <R03093>       transform      megacary
                  E1, NF-    chick,              7.4/bin/get    ,              ed cells, it   ocytes,
                  E1a,       Gallus   vertebrate TFProf.cgi     <R03213>       can also       eosinophil
T00267   GATA-1   Eryf1.     gallus   s          ?T00267        ,              induce         s [15] [2]
                                                                transcripti    required
                                                                on of          for
                                                                GATA-1         erythroid
                                                                gene in        differentiat
                                                                testis and     ion [24]
                                                                erythroid      GATA-1
                                                                cells          negative
                                                                initiates      proerythro
                                                                at             blasts
                                                                different      undergo
                                                                promoters      developm
                                                                 [2] [17] C-   ental
                                                                terminal       arrest
                                                                but not N-     and death
                                                                terminal       [18]
                                                                zinc           GATA-2
                                                                finger         (mRNA)
                                                                required       level is
                                                                for DNA        elevated
                                                                binding        in GATA-
                                                                [29] and       1
                                                                interaction    negative
                                                                 with Sp1      proerythro
                                                                <T00752>       blasts but
                                                                 [11] N-       does not
                                                                terminal       compensa
                                                 http://local   zinc           te for
                  EF1,                           host/cgi-      finger is      GATA-1         erythroid
                  EFgamma                        bin/biobas     largely        deficiency     and
                  a, Eryf-1,                     e/transfac/    dispensab      [18]           megacary
                  GATA-1, mouse,                 7.4/bin/get    le in          GATA-1         ocytic
                  GF-1, NF- Mus       vertebrate TFProf.cgi     nonhema        gene           cells, [3]
T00305   GATA-1   E1 (1).    musculus s          ?T00305        poietic        expressio      [1] [17].
                                                                               activator
                                                                               negative
                                                                               regulator
                                                                               of
                                                                               gamma-
                                                                               globin in
                                                                               adults
                                                                               down-
                                                                               regulated
                                                                               by TPA
                                                                               [28] up-
                                                                chromoso       regulated
                                                                mal            by
                                                                position       aclacinom
                                                                at Xp21-       ycin
                                                                11 [33]        (ACM)
                                                                zinc           [14] acts
                                                                finger 2 is    on the
                                                                able to        PBGD
                                                                bind DNA       and
                                                                on its         gamma-
                                                                own but        globin
                                                                zinc           promoter
                                                                finger 1       in
                                                                contribute     associatio
                  EF1                                           s strongly     n with
                  (chick),                       http://local   to the         Sp1 or
                  EFgamma                        host/cgi-      stability of   CCACC
                  a, Eryf1                       bin/biobas     DNA            binding
                  (chick),                       e/transfac/    binding at     proteins
                  GATA-1, human,                 7.4/bin/get    some           [10] [13]
                  GF-1, NF- Homo      vertebrate TFProf.cgi     particular     [17]         eosinophil
T00306   GATA-1   E1.       sapiens   s          ?T00306        sites [6]      significantl s [3]
                                                               during
                                                               embryonal

                                                               developm
                                                               ent first
                                                               the level   erythroid
                                                               of GATA-    cells
                                                               1A          (mainly
                                                               mRNA        embryonal
                                                               predomin    , prior to
                                                               ates but    terminal
                                                               in later    differentiat
                                                http://local   stages      ion) [1]; in
                                                host/cgi-      and in      the
                                                bin/biobas     adult       ventral
                           clawed               e/transfac/    erythroid   region of
                           frog,                7.4/bin/get    cells       the
                           Xenopus   vertebrate TFProf.cgi     GATA-1B     embryo
T00304   GATA-1A GATA-1.   laevis    s          ?T00304        mRNA [1].   [1].
                                                              class A       activator
                                                              specific      [8] poorly
                                                              domain        DNA-
                                                              [15]          binding
                                                              putative      as
                                                              leucine       homodime
                                                              zipper        r due to
                                                              motif         an
                                                              (L2TL2)       inhibitory
                                                              may be N-     N-
                                                              terminally    terminal
                                                              extended      domain,
                                                              due to the    but avid
                                                              lack of       DNA-
                                                              Q390 in       binding in
                                                              [28]          any
                                                              which         heterodim
                                                              brings an     eric
                                                              additional    complex
                                                              L in          [27] [15]
                                                              phase         the
                                                              spontaneo     inhibitory
                                                              us            region
                                                              homodime      also
                                                              rization in   defines
               E12,                                           B cells,      different
               E2A.E12,                        http://local   stabilized    DNA-
               E2A-E12,                        host/cgi-      by            binding
               Pan-2                           bin/biobas     disulfide     specificitie
               (rat), E2-                      e/transfac/    links [5]     s
               alpha,     human,               7.4/bin/get    reducing      between
               TCF3,      Homo      vertebrate TFProf.cgi     activity in   E12 and
T00204   E12   E2A.       sapiens   s          ?T00204        muscle        E47 [15] ubiquitous


                                              http://local
                                              host/cgi-
                                              bin/biobas
                         rat,                 e/transfac/
                         Rattus               7.4/bin/get
               E12, Pan- norvegicu vertebrate TFProf.cgi
T00675   E12   2, E2A.   s         s          ?T00675                                 NULL
                                                             homodime
                                                             rs and
                                                             heterodim
                                                             ers withfunctional
                                                             MASH-2  redundan
                                                             or ITF-2cy of E2A
                                                             are     and E2-2
                                                                     gene
                                                             inhibited
                                                             from    products
                                                             DNA-    [5],
                                                             binding except
                                                             by      mature B
                                                                     cells
                                                             interaction
                                                              of the where
                                                             bHLH    E2A
                                                             domain  products
                                                             with    (E12/E47)
                                                             calcium/care
                                                                     found
                                                             almodulin
                                                             complexeexclusivel
                                                             s,      y making
                                                             whereas mature B
                                                             E12/MyoDcell
                                                                     developm
                                                           heterodim ent E2A-
                                                           ers are   dependent
                                              http://local resistant  [2]
                                              host/cgi- [3]          required
                                              bin/biobas flanking    for Pax-5
                                              e/transfac/ bases of <T01201>
                          mouse,              7.4/bin/get the IgH E-
                          Mus      vertebrate TFProf.cgi box         expressio
T01786   E12   A7, E2A.   musculus s          ?T01786 specificall n [2]         NULL


                                              http://local
                                              host/cgi-
                                              bin/biobas
                         rat,                 e/transfac/
                         Rattus               7.4/bin/get
               E47, Pan- norvegicu vertebrate TFProf.cgi
T00674   E47   1, E2A.   s         s          ?T00674                               NULL

                                                                           functional
                                                                           redundan
                                              http://local                 cy with
                                              host/cgi-                    other
                                              bin/biobas                   products
               a1, E47,                       e/transfac/                  of the
               shPan1     mouse,              7.4/bin/get                  E2A and
               (hamster), Mus      vertebrate TFProf.cgi                   E2-2
T01788   E47    E2A.      musculus s          ?T01788                      genes [2] NULL
                                                                              myogenic
                                                                              factor,
                                                                              transcripti
                                                                efficient     onal
                                                                DNA-          activator
                                                                binding       [9]
                                                                only after    activates
                                                                heterodim     MyoD
                                                                erization     and
                                                                with (e.g.)   myogenin
                                                                E12 [4]       genes
                                                                strong        expressio
                                                                cooperatio    n
                                                                n             repressed
                                                                between        by MyoD
                                                                N- and C-     or
                                                                terminal      myogenin
                                                                domains       [9] it is
                                                                for MRF4-     transiently
                                                                specific
                                                                transcripti   expressed
                                                                onal           after
                                                                activation    myogenin,
                                                                [6]            before
                                                                phosphory     MyoD,
                                                                lation at     and
                                                http://local    several       reappears
                                                host/cgi-       Ser and        during
                herculin                        bin/biobas      Thr by        late stage
                (mouse),   rat,                 e/transfac/     PKA and       of
                MRF4,      Rattus               7.4/bin/get     PKC in        skeletal
                Myf-6      norvegicu vertebrate TFProf.cgi      vitro and     muscle     myogenic
T00512   MRF4   (human).   s         s          ?T00512         in vivo       developm cells


                                                 http://local   MyoD
                                                 host/cgi-      does not
                                                 bin/biobas     heterodim
                                                 e/transfac/    erize with
                MEF1,      human,                7.4/bin/get    other       myogenic
                Myf-3,     Homo       vertebrate TFProf.cgi     myogenic transcripti myogenic
T00525   MyoD   MyoD.      sapiens    s          ?T00525        factors [1] on factor cells
                                                               at high        muscle-
                                                               concentrat     specific
                                                               ions:          transcripti
                                                               homodime       on
                                                               ric DNA-       activator
                                                               binding at     may have
                                                               low            to
                                                               concentrat     cooperate
                                                               ions,           with
                                                               myogenin       other
                                                               has to         transcripti
                                                               heterodim      on factors
                                                               erize for      (NF-1,
                                                               DNA-           MEF-2,
                                                               binding        COMP1)
                                                               [17]           [8] may
                                                               important      have
                                                               for            specific
                                                               muscle-        function
                                                               specific       for
                                                               trans-         muscle
                                                               activation     formation
                                                               and            in some
                                                               differentiat   regions of
                                                               ion: A86,      the
                                                               T87 [23]       embryo,
                                                http://local   N- and C-      particularl
                                                host/cgi-      terminal       y in the
                                                bin/biobas     regions        latero-       myogenic
                  Myf-4                         e/transfac/    have to        ventral       cells;
                  (human), mouse,               7.4/bin/get    cooperate      body wall     skeletal
                  MyoG,     Mus      vertebrate TFProf.cgi      for full      disruption    muscle
T00528   myogenin myogenin. musculus s          ?T00528        transcripti    of its        cells
                                                                       muscle-
                                                                       specific
                                                                       transcripti
                                                                       on
                                                                       activator
                                                                       induces
                                                                       myogenic
                                                                       differentiat
                                                                       ion [5]
                                                                       expressed
                                                                        after Myf-
                                                                       5 and
                                                                       before
                                                                       MRF4
                                                                       and
                                                                       MyoD, at
                                                                       low level
                                                                       in the
                                                                       skeletal
                                                                       muscle of
                                                                       adult rats
                                                                       [5]
                                                                       positively
                                                                       regulated
                                                                       by MyoD
                                                                       [6], by
                                                 http://local          IGF-I or
                                                 host/cgi- preferenti other
                                                 bin/biobas al         signal         myogenic
                            rat,                 e/transfac/ heterodim pathways       cells;
                            Rattus               7.4/bin/get erization involving      skeletal
                            norvegicu vertebrate TFProf.cgi with E12 G                muscle
T01532   myogenin           s         s          ?T01532 [3] [1]       proteins       cells [5]


                                                  http://local
                                                  host/cgi-
                                                  bin/biobas
                            clawed                e/transfac/
                    E12,    frog,                 7.4/bin/get
                    XE12,   Xenopus    vertebrate TFProf.cgi
T01787   E12        E2A.    laevis     s          ?T01787                             NULL
                                                             multiple      activator
                                                             splice        mediates
                                                             variants      cAMP-
                                                             [27]          response
                                                             leucine       after
                                                             zipper-       phosphory
                                                             independe     lation at
                                                             nt binding    Ser-133
                                                             of the        by PKA
                                                             coactivato    within the
                                                             r CBP         kinase-
                                                             [16] the      inducible
                                                             Tax           domain
                                                             activator     (KID) [32]
                                                             of HTLV-I     KID
                                                             interacts     cooperate
                                                             with the      s with Q2
                                                             basic         domain in
                                                             region [6]    transcripti
                                                             [7]           onal
                                                             decreasin     stimulatio
                                                             g the         n Q2          spleen,
                                                             dissociatio   interacts     heart,
                ATF-47,                                      n             with the      thymus,
                CREB,                                        constant      TAF-110       lymphocyt
                CREB-                                        for CREB      componen      es, gut,
                341,                          http://local   homodime      t of TFIID    brain,
                CREBalph                      host/cgi-      rs (from 7    [10]          kidney;
                a, CREB-                      bin/biobas     nM to 0.1     dephosph      very
                B, X2BP,                      e/transfac/    nM) and       orylation     weak
                X2-box   human,               7.4/bin/get    for           may be        expressio
                binding  Homo      vertebrate TFProf.cgi     (CREB)2-      by            n in testis
T00163   CREB   protein. sapiens   s          ?T00163        DNA           nuclear       and liver
                                                               multiple      cAMP-
                                                               splice        dependent
                                                               variants
                                                               [22] [33]     phosphory
                                                               pI            lation by
                                                               (cal.)=5.7-   PKA
                                                               6.0 [28]      leads to
                                                               leucine       induction
                                                               zipper-       of trans-
                                                               independe     activation
                                                               nt binding    [45] [46]
                                                               of            [43] PKA
                                                               coactivato    regulatory
                                                               r CBP         subunit
                                                               [13]          RIalpha is
                                                               interaction   encoded
                                                                with CBP     by the
                                                               is not        tissue-
                                                               inhibited     specific
                                                               by            extinguish
                                                               introducin    er locus,
                                                               ga            Tse1,
                                                               negative      which
                                                               charge in     mediates     spleen,
                                                               position      deactivati   heart,
                ATF-47                                         142           on of        thymus,
                (human),                        http://local   (serine       CREB         gut, brain,
                CREB,                           host/cgi-      phosphory     [35] also    kidney;
                CREB-                           bin/biobas     lation or     phosphory    very
                341,       rat,                 e/transfac/    Asp-          lation of    weak
                CREBalph   Rattus               7.4/bin/get    substitutio   Ser-133      expressio
                a, CREB-   norvegicu vertebrate TFProf.cgi     n) [4] the    by CaM       n in testis
T00164   CREB   B.         s         s          ?T00164        Tax           kinases I,   and liver
                                                            there are     strong
                                                            mutiple       activator,
                                                            splice        mediating
                                                            variants      gene
                                                            arising       activation
                                                            from the      in
                                                            CREB          response
                                                            gene [10]     to cyclic
                                                            CREBalph      AMP
                                                            a is the      after
                                                            largest       phosphory
                                                            and most      lation
                                                            abundant      normal
                                                            isoform       function
                                                            encoded       is
                                                            by exons      required
                                                            2, 4, 5, 7-   for long-
                                                            10a, 11       term
                                                            [10] the      memory
                                                            coactivato    [4]
                                                            r CBP         repression
                                                            and the        in
                                                            negative      undifferen
                                                            regulator     tiated
                                                            CBP100        cells by
                                                            interact      CBP100
                                             http://local   with          [8] loss of
                                             host/cgi-      CREB          CREB
                                             bin/biobas     independe     and           ubiquitous
                                             e/transfac/    nly of the    DeltaCRE      , most
                CREB,    mouse,              7.4/bin/get    leucine       B may be      abundant
                CREBalph Mus      vertebrate TFProf.cgi     zipper [8]    compensa      in brain
T00989   CREB   a.       musculus s          ?T00989        [6] Q2 is     ted by        [14]
                                                                      becomes
                                                                      phosphory
                                                                      lated in
                                                                      hippocam
                                                                      pal
                                                                      neurons
                                                                      upon light
                                                                      exposure
                                                                      of the
                                                                      animals
                                                                      [2] in
                                                                      addition
                                                                      to
                                                                      enhanced
                                                                      activity by
                                                                      PKA-
                                                                      dependent

                                                                      phosphory
                                                                      lation, a
                                                                      calcium-
                                                                      dependent

                                                                      activation
                                                                      of
                                                                      calcineuri
                                             http://local             n
                                             host/cgi-                phosphata
                                             bin/biobas               se is also
                                             e/transfac/              necessary
                                             7.4/bin/get               for full
                                  vertebrate TFProf.cgi               trans-
T01307   CREB   CREB.   hamster   s          ?T01307                  activation NULL


                                                                       Phosphor
                                                                       ylation by
                                                                       a kinase
                                                                       different
                                                                       from PKA
                                                                       is
                                                                       induced
                                                                       by TGF-
                                                                       beta1,
                                                                       leading to
                                             http://local              enhanced
                                             host/cgi-                 binding to
                                             bin/biobas                a TRE
                                             e/transfac/               but does
                        mink,                7.4/bin/get               not alter
                        Mustela   vertebrate TFProf.cgi                binding to (ML-
T01380   CREB   CREB.   vison     s          ?T01380        pI 5.7-6.0 CRE        CCl64)
                                                                          Bovine
                                                                          CREB is
                                                                          phosphory
                                                                          lated
                                                                          either by
                                                                          cAMP-
                                                                          dependent
                                                                           protein
                                                 http://local             kinase or
                                                 host/cgi-                by by
                                                 bin/biobas               Ca2+/cal
                                                 e/transfac/              modulin-
                            cattle,              7.4/bin/get              dependent
                            Bos       vertebrate TFProf.cgi     phosphory protein
T01385   CREB       CREB.   taurus    s          ?T01385        lation    kinase    (brain)




                                                                          activator,
                                                                          activating
                                                                          capability
                                                                          comparabl
                                                                          e with
                                                                          CREB [1]
                                                                          ubiquitous
                                                                          ly
                                                                          expressed
                                                                           at very
                                                                          low
                                                                          levels,
                                                                          significantl
                                                                          y up-
                                                                          regulated
                                                                          in
                                                                          CREB/Del
                                                                          taCREB
                                                                          knock-out
                                                                          mice thus
                                                http://local              compensa
                                                host/cgi-       encoded ting the
                                                bin/biobas      by creb   loss of
                                                e/transfac/     gene      major
                            mouse,              7.4/bin/get     exons 4, CREB
                            Mus      vertebrate TFProf.cgi      7-10a, 11 variants     ubiquitous
T02361   CREBbeta           musculus s          ?T02361         [1]       [1]          [1]
                                                               encoded       repressor,
                                                               by crem        CREB
                                                               exons 1       antagonist
                                                               (B), 3 (E),    as
                                                               4 (F), 6      dominant
                                                               (X), 7 (H),   negative
                                                               and the 5     regulator
                                                               -half of      [8] [4]
                                                               exon 8        may
                                                               (Ia)          confer
                                                               several       cAMP/PK
                                                               alternative   A-
                                                                splice       dependent
                                                               variants       effects,     mRNA:
                                                               including     even          adult
                                                               some          stimulator    brain:
                                                               with an       y ones,       innerlayer
                                                               alternative   onto          of
                                                                DNA-         other         cerebral
                                                               binding       factors       cortex,
                                                               domain        bound in      anterior
                                                               [8] very      the           thalamus,
                                                               similar if    vicinity of   hippocam
                                                               not           CREMalp       pus,
                                                               identical     ha [2]        hypothala
                                                               DNA-          CREMalp       mus [6],
                                               http://local    binding       ha is         pituitary
                                               host/cgi-       specificity   upregulate    gland;
                                               bin/biobas      as CREB       d in          kidney,
                                               e/transfac/     [8] homo-     CREB -/-      heart;
                           mouse,              7.4/bin/get     and           mice use      very low
         CREMalp CREM-     Mus      vertebrate TFProf.cgi      heterodim     of an         levels in
T01314   ha      alpha.    musculus s          ?T01314         eric DNA-     alternative   testis [7]


                                                http://local
                 CREM,                          host/cgi-
                 cAMP-                          bin/biobas
                 responsiv                      e/transfac/
                 e element human,               7.4/bin/get
         CREMalp modulator Homo      vertebrate TFProf.cgi
T01803   ha       alpha.   sapiens   s          ?T01803                                    NULL
                                                                           repressor,
                                                                            CREB
                                                                           antagonist
                                                                            as
                                                                           dominant
                                                                           negative
                                                                           regulator
                                                                           [6] [3]
                                                                           CREMbet
                                                               encoded a is
                                                               by exons upregulate
                                                               1 (B), 3    d in
                                                               (E), 4 (F), CREB -/-
                                                               6 (X), 7    mice
                                                               (H), and repressor
                                                               the 3 -     function
                                                               half of     is
                                                               exon 8      relieved
                                                               (Ib)        by
                                                               several     phosphory
                                                               alternative lation of
                                                                splice     Ser-68,
                                                               variants    presumabl
                                                               [6] binds y by PKA
                                                               with        [3]
                                                               higher      osmotic
                                             http://local      affinity    stimulatio
                                             host/cgi-         than        n of the       mRNA:
                                             bin/biobas        CREMalp supraoptic         pituitary
                                             e/transfac/       ha to a      nucleus,      gland,
                         mouse,              7.4/bin/get       series of induction        brain,
         CREMbet CREMbet Mus      vertebrate TFProf.cgi        different of               kidney,
T01315   a       a.      musculus s          ?T01315           CREs [3] CREMbet           heart [5]

                                                               encoded
                                                               by exons
                                                               1 (B), 3
                                                               (E), 4 (F),
                                                               7 (H),
                                                               and the 3
                                                               -half of      repressor,
                                                http://local   exon 8         CREB
                                                host/cgi-      (Ib)          antagonist   mRNA:
                                                bin/biobas     several        as          pituitary
                                                e/transfac/    alternative   dominant     gland,
                            mouse,              7.4/bin/get     splice       negative     brain,
         CREMga   CREMga    Mus      vertebrate TFProf.cgi     variants      regulator    kidney,
T01316   mma      mma.      musculus s          ?T01316        [4]           [4] [2]      heart [3]
                                                              encoded       activator
                                                              by crem       [10] [9]
                                                              exons 1       required
                                                              (B), 2 (C),   for
                                                              3 (E), 4      spermatid
                                                              (F), 5 (G),   differentiat
                                                              6 (X), 7      ion into
                                                              (H), and      sperms
                                                              the 3 -       [2] [1]
                                                              half of       abrupt
                                                              exon 8        switch
                                                              (Ib)          from
                                                              several       repressing
                                                              splice         CREM
                                                              variants      isoforms
                                                              [9]           to
                                                              compared      CREMtau
                                                               to alpha,    during
                                                              beta and      spermato
                                                              gamma         genesis
                                                              isoforms,     [10]
                                                              CREMtau       alternative
                                                              contains       initiation
                                                              two           usage
                                                              additional    yields S-
                                                              glutamine-    CREM           adult
                                              http://local    rich          CREMtau        testis;
                                              host/cgi-       regions       is             (much
                                              bin/biobas      which         upregulate     weaker:)
                                              e/transfac/     exert an      d in           neuroend
                          mouse,              7.4/bin/get     activating    CREB -/-       ocrine
                          Mus      vertebrate TFProf.cgi      effect, the   mice           tissues
T01309   CREMtau CREMtau. musculus s          ?T01309         second        mediates       [10]
                                                                            transcripti
                                                                            onal
                                                                            activator
                                                                            [2]
                                                                            involved
                                                                            in the
                                                                            cAMP
                                                                            dependent

                                                                            regulation
                                               http://local                 of
                                               host/cgi-                    catechola
                                               bin/biobas                   mine
                          rat,                 e/transfac/                  neurotran
                          Rattus               7.4/bin/get                  smitter
                          norvegicu vertebrate TFProf.cgi                   biosynthe
T01919   CREMtau CREM-Ib. s         s          ?T01919                      sis [1]    NULL
                                                                encoded
                                                                by crem
                                                                exons 1
                                                                (B), 2 (C),
                                                                3 (E), 4
                                                                (F), 6 (X),