Psychological Assessment and Intervention Future Prospects for

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					                                                                        Seminars in Surgical Oncology 12:76-83 (1996)

                  Psychological Assessment and Intervention:
                      Future Prospects for Women With
                                 Breast Cancer
                                  LESLIE G. WALKER MA. PhD. AND OLEG EREMIN, MD
                     From the Behavioural Oncology Unit, Departments of Mental Health and Surgery,
                                Aberdeen University Medical School, Aberdeen, Scotland

                     During the last decade, there has been a growing interest in the psycho-
                     social aspects of breast cancer. Studies have addressed multifarious
                     aspects, including the possible importance of personality factors and
                     stress in the onset and progression of malignancy, the psychological
                     impact of diagnosis and treatment, the incidence and nature of psycho-
                     logical and psychiatric problems, the development and evaluation of
                     psychological interventions to ameliorate treatment side effects and to
                     enhance quality of life, the psychological effects of screening for breast
                     cancer and of counselling women at high risk, the organization of
                     services, training, and psychoneuroimmunology. These and other
                     studies are reviewed and possible directions for future research are
                     indicated. It is clear that psychosocial factors are becoming increas-
                     ingly important components of the assessment and management of
                     patients with breast cancer.     @1996 Wiiey-Liss. Inc.

                 KEYWORDS:psychosocial oncology, counseling, screening, psychoneuroimmunology,
                               communication, personality

                   INTRODUCTION                             clinically significant levels of anxiety and/ or depres-
   In recent years there has been a growing awareness,      sion and that 33% had moderate or severe sexual diffi-
by the medical profession and the lay public, of the        culties. Other studies have reported a high incidence of
psychosocial impact of the diagnosis and treatment of       problems related to body image following mutilating
cancer. The former have responded to this in several        surgery [2].
ways, including the widespread use of quality of life          Breast conservation causes less initial psychological
assessments in clinical trials and the development of       morbidity than mastectomy. Unfortunately, however,
the new discipline of psychosocial, or behavioural,         it does not appear to reduce significantly the preva-
oncology. For its part, the public has shown an intense     lence of psychological morbidity in the longer term [3].
curiosity in the causes and treatment of cancer and this    Women treated with breast conservation may become
is demonstrated by the frequent coverage of cancer on       more anxious with the passage of time because they
television, radio, magazines, and newspapers. Partly        fear, rightly or wrongly, that they may have jeopar-
because it is so common, and also because of its per-       dised survival for the sake of a good cosmetic result.
ceived psychosexual implications, breast cancer has         Although some patients may benefit psychologically
had an especially high media profile in recent years.       from conservation, especially if they wish to exercise
                                                            choice and favour this procedure, it seems unlikely
 PSYCHOLOGICAL PROBLEMS OCCURRING                           that this will have a substantial beneficial effect on the
               IN BREAST CANCER                             overall incidence of psychiatric morbidity.
  A number of studies have examined the incidence of           Other studies have evaluated the effect of breast
psychological and psychiatric morbidity in women
                                                             Address reprint requests to L.G. Walker, Behavioural Oncology
with breast cancer. A classic study by Maguire et al. [I]    Unit. Aberdeen University Medical School, Foresterhill, Aber-
found 1 year after surgery that 25% of women had             deen, AB9 ZZD, Scotland.

0 1996 Wiley-Liss, Inc.
                                                                      Psychological Assessment and Interventions 77

  reconstruction. Dean et al. [4] studied 64 women with    support received, side-effect control, and treatment
 operable breast cancer, all of whom underwent mas-        ambience.
 tectomy, and randomised them to immediate or                 Fallowfield and Clark [6] have studied the effects of
 delayed (3 months) reconstruction. Immediate recon-       patient participation in decision making regarding the
 struction reduced psychiatric morbidity 3 months          type of surgery performed for breast cancer. Participa-
 after mastectomy, especially in women whose mar-          tion had important beneficial effects on subsequent
 riages were unsatisfactory. The incidence of psychiat-    psychological adjustment for most women. However,
 ric disorder at 12 months, however, was similar in the    there appears to be a subgroup of women who do not
 two groups, although it should be noted that it was       wish to be involved in making the choice between
 lower than in most studies of women who have under-       lumpectomy or mastectomy.
 gone mastectomy. We are currently evaluating the at-         The diagnosis of breast cancer is frequently trau-
 titudes of women with breast cancer toward breast         matic and it is known that many women are unable to
 reconstruction in the context of neo-adjuvant chemo-      take in all the information that is given to them at the
 therapy. To date, our findings indicate that, initially   “bad news” interview. In an attempt to overcome this,
 following diagnosis, many women are enthusiastic          Hogbin and Fallowfield [7] carried out a randomised
 about the possibility of subsequent breast reconstruc-    study to evaluate the effects of recording the interview
 tion. However, at primary surgery, less than 10% ex-      when “bad news” and diagnosis were initially dis-
press a strong desire for reconstruction. As these         cussed and giving this to patients so that they had a
 women have large or locally advanced primary can-         permanent record of what was said and could listen to
cers, they undergo radiotherapy postoperatively.           this as often as they wished, on their own, or with
 Some have indicated, however, that if reconstruction      others. Although this was helpful to some patients, it
could be carried out at the same time as mastectomy,       appeared to have an adverse effect on other women,
 they would wish this to be done.                          particularly those who had a very bad prognosis. It is
    In an ongoing study of the psychoneuroimmuno-          very important that clinicians are sensitive to the cues
logical effects of relaxation training and guided imag-    given by patients in order that they can tailor the
ery in women with locally advanced breast cancer, we       information given to the patients’ needs. Patients
are finding a very low incidence of anxiety and depres-    should be given the information they wish and require
sion 9 months after diagnosis, whether assessed by a       over a period of time: coming to terms with the diag-
standardised interview or by psychological tests. This     nosis and treatment takes time and the information
applies not only to those women receiving the psycho-      that patients wish or need may vary during this period.
logical intervention, but also to our control group. All
the women in the trial receive a great deal of support                         ASSESSMENT
and have much more contact with staff than would be           From a practical clinical point of view, it is impor-
the case in routine practice. Apart from those who live    tant to have a high index of suspicion regarding the
very far from the hospital, the women attend on 18         presence of psychological and psychiatric problems.
occasions during the 18 weeks when they are receiving      Medical and other staff frequently fail to identify these
neo-adjuvant chemotherapy and they are assessed fur-       problems for various reasons, including failure to use
ther prior to, and after, surgery and radiotherapy.        screening questions that might elicit morbidity, the use
Great efforts are made to reduce the waiting time for      of blocking maneuvers that decrease the likelihood
chemotherapy, to provide them with the amount of           that patients will report emotional problems and fear
information they wish and to give them a high stan-        that the patient will disclose concerns or feelings that
dard of support. Questionnaires show very high levels      might be difficult to handle in a constructive way [8].
of satisfaction with the treatment received and their      This raises many questions about who should take
relationship with staff. We believe these factors may be   responsibility for identifying these problems, in what
important in preventing psychiatric morbidity. This        setting, and with what training and professional back-
view is further supported by our findings in women         grounds.
with gynaecological cancer [5].Women who were anx-            When clinicians identify significant distress, they
ious or depressed at follow-up were significantly less     may not offer treatment because they see the distress
satisfied with the information they had received fol-      as being a “normal” reaction to the diagnosis, treat-
lowing diagnosis and with doctor-patient relation-         ment side effects, or prognosis. The situation is further
ships. Future research into psychiatric morbidity in       complicated by the symptoms of cancer and treatment
women with breast cancer will need to take much            side effects. For example, reduced energy and libido,
more account of psychosocial and contextual aspects        appetite change, sleep disturbance and social with-
of their management, including information given,          drawal are not as reliable symptoms of depression in
78 Walker and Eremin

cancer patients as they are in physically healthy in-         be merit in developing further scales to assess other
dividuals. although they should still be assessed care-       potentially important aspects such as satisfaction with
fully. Enquiries regarding the ability to experience          information received, expectancies regarding treat-
pleasure, diurnal variation in mood, early morning            ment side effects and likelihood of therapeutic success,
wakening, self-concept, and views about the future            and the impact of the illness and its treatment on
can be more revealing about the patient’s mental state.       others, for example partners and children.
The presence of psychomotor agitation and retarda-                Ideally, patients should be assessed and followed up
tion is also of diagnostic value. When appropriate, it        by a liaison psychiatrist, clinical psychologist or spe-
is also important to assess suicidal ideation and intent.     cially trained nurse. Considerable tact is required, and
Symptoms of fear and anxiety are generally much               judgment should be used to determine how detailed a
easier to evaluate than those of depression in this pop-      mental state examination should be carried out in an
ulation.                                                      individual case. On the one hand, it is important that
   A number of simple, self-report questionnaires are         treatable problems are identified as soon as possible:
available to screen for psychological problems. The           on the other, it is essential that women do not feel that
Hospital Anxiety and Depression Scale [9] is a 14-item        undue intrusions are being made into their adjust-
questionnaire that assesses both anxiety and depres-          ment, feelings, and circumstances. Most patients who
sion. It can be completed in 2 or 3 minutes and scored        are having psychological problems welcome the op-
in the same time. Low scores (7 or less) on either scale      portunity to discuss these with a sensitive and em-
strongly suggest that these parameters are within nor-        pathic clinician who conveys to them that discussion
mal limits. As a rough guide, patients who score              of such factors is acceptable and will be taken seri-
higher, particularly 8 or above on depression and 11          ously. However, there is a subgroup of women who do
or above on anxiety, are likely to have clinically sig-       not wish counseling and who may even be harmed by
nificant problems that require further assessment and         it because, for example, they successfully use denial as
appropriate psychological or psychopharmacological            a way of coping with their illness.
treatment. The Rotterdam Symptom Check List [ 101                 In an important series of studies, Maguire et al. [I51
contains approximately 30 items (there are several ver-        have addressed the role of specially trained nurse
sions) and yields separate scores of psychological and        counselors in identifying and managing psychiatric
physical distress. In addition to subscale scores, re-        morbidity. Although there was no evidence that nurse
sponses to individual items, for example the one deal-        counselors prevented morbidity, they were successful
ing with libido, can alert the clinician to the possibility    in identifying patients who had significant problems.
of very specific problems.                                     If these were referred for appropriate treatment, the
   A number of other quality-of-life measures have            subsequent incidence of psychiatric problems was less
been published, for example, the European Organisa-            in the patients who had contact with the counsellor
tion for Research and Treatment of Cancer (EORTC)             than in those who did not. However, counselors need
QLQ-C30 [l I], the Patient Attitude to Illness Scale           backup and support, or they may become chronically
[12], and the Short Form 36-item Health Survey (SF-            stressed and “burnt out.”
36) [13]. Because quality of life is defined in terms of          Some chemotherapy regimens have been shown to
the individual’s needs and priorities, and is not simply       affect cognition and psychomotor performance. Regi-
a function of the presence or absence of specific symp-        mens used in breast cancer, for example, CHOP che-
toms, recent interest has focused on individualised            motherapy, have not been adequately documented,
quality-of-life measures [ 141. These measures reflect         although clinically many women complain of memory
those aspects of life that a particular individual con-        problems. In future, sophisticated computerised as-
siders important, and they assess current functioning          sessments such as the one developed by Cognitive
and satisfaction in each of these aspects as well as their     Drug Research could be used to assess the effects of
relative importance. Although some of these measures           chemotherapy (or indeed radiotherapy) on various
are statistically sophisticated, they are still at an early    kinds of memory, vigilance, reaction time, and so on.
stage of development, and they are more complicated            This program was found to be very useful in evaluat-
to administer than the symptom checklists described            ing the effects of recombinant interleukin-2 therapy in
above. Undoubtedly, despite the difficulties, efforts          patients with advanced colorectal cancer [ 161.
will be made in the future to develop individualised              One other aspect of assessment is likely to be rele-
measures.                                                      vant in the future. If psychosocial factors are indepen-
   Other questionnaires are available to assess quan-          dent prognostic factors for survival (see below), it will
titatively aspects of body image, social support, and          be important in a research context to assess these to
various features of personality. In future, there would        ensure that patients in the various treatment arms of
                                                                     Psychological Assessment and Interventions 79

a clinical trial are comparable not only for known            Second, what is the psychological impact of a false
biological prognostic factors (e.g., lymph node inva-     positive recall? In the United Kingdom, approxi-
sion, histopathology, and hormonal receptor status),      mately 8% of women are recalled for further assess-
but also for these psychosocial indices.                  ment because of a mammographic abnormality. Sev-
                                                          eral studies have addressed this issue. We found that
    SCREENING AND GENETIC COUNSELING                      recall was associated with increased anxiety whether
    Considerable concern was expressed during the         assessed by mean scores or clinically significant cate-
 1980s about the possible adverse psychological effects           2]
                                                          gories [ 2 .However, when the women were reassessed
 of screening for breast cancer. It was suggested that    4 months later, mean anxiety scores were significantly
 screening might not only be distressing but, in some     lower than at baseline assessment, and depression
 patients, might result in psychiatric disorder, cancer   scores had returned to the baseline level. These find-
 phobia, or an inappropriate frequency of breast self-    ings are consistent with other work which has failed to
 examination. A number of empirical studies have in-      find a significant, persistent increase in psychiatric
 vestigated these matters [ 17-20]. There are at least two
                                                         morbidity some months after recall.
 important issues that need to be addressed, namely the      Over the past few years, a number of centres in the
 effects of attendance at screening and the impact of     United Kingdom have established high risk family
 false-positive recall.                                  clinics where women receive counselling regarding
    First, does attending for breast screening have psy- their genetically determined risk of breast cancer. The
 chonoxious effects? Almost one million women attend     long-term effects of such counselling have not yet been
 annually for routine mammography as part of the         adequately evaluated, although a number of studies
 United Kingdom National Health Service breast           have been reported or are in progress [23]. In our own
 screening program. One of the problems in evaluating    clinic, an ongoing follow-up study of 89 women has
the effect of breast screening is in obtaining a baselineshown that, compared with pre-counselling, depres-
measurement of mental health that is uncontaminated      sion scores were higher 18 months after counselling.
by the knowledge of the impending screening visit. It    Although highly statistically significant, the actual
is possible to compare a group of women who attend       magnitude of the increase is relatively small. The exact
screening with another group who do not. However,        nature of the distress, and its clinical significance, war-
there are difficulties in getting a truly comparable     rants more detailed study. Although some women can
group for comparison and a “within group” design for     identify accurately their own risk prior to counseling,
patients who are screened is likely to be more sensitive.this is by no means true for all women and change in
In a recent study, we used the latter design [21]. We    risk perception following counselling, moderated by
identified three local general practices who were sched- personality, social support, etc., may produce differen-
uled for screening and, with the help of the General     tial outcomes.
Practitioners, we were able to obtain a baseline mea-        Cull et al. [24] reported that women who overesti-
sure of mental health uncontaminated by the screen-      mated their risk experienced reduced anxiety follow-
ing process. Each woman received a letter from her       ing counseling: however, this returned to baseline lev-
General Practitioner indicating that he/ she was carry-  els within 3 months. Moreover, although counseling
ing out a survey of various aspects of the health of     appeared to increase the accuracy of risk perception in
women in the practice and inviting them to complete      underestimators, these women continued to underesti-
an enclosed Hospital Anxiety and Depression Scale.       mate their risk.
At that time the women did not know that they were           In Huntington’s disease, psychiatric morbidity has
to be invited for screening a few weeks later. More      been shown to be higher following counseling in those
than 2,000 women responded to this postal question-      not carrying the gene compared with those who have
naire (an 89.5% response rate). When they attended       the gene. It may be that some women who are less at
screening, the women were asked to complete a further    risk of breast cancer on genetic testing will also show
Hospital Anxiety and Depression Scale, so that their        survivor guilt.” Following genetic counseling, the
levels of anxiety and depression at that time point      provision of a psychosocial intervention may reduce
could be compared with the baseline measurements.        any detrimental impact.
The results showed clearly that, as a group, women
were significantly less anxious and less depressed prior         PSYCHOLOGICAL MANAGEMENT
to screening than at their baseline assessments. This        We have already commented on the important
was true for mean anxiety and depression scores as beneficial effects of contextual aspects of management,
well as for the proportion of women reporting clini- such as appropriate information, patient satisfaction
cally significant levels of anxiety and depression.        with communication, and good control of side effects.
80 Walker and Eremin

However, a number of studies have shown that formal         used, it is important to choose drugs which have as few
psychological interventions can be used successfully to     side effects as possible. Women undergoing treatment
treat psychiatric morbidity once it has been diagnosed.     for breast cancer may already be experiencing gas-
    Greer et al. [25] carried out a prospective, rando-     trointestinal disturbances, nausea and fatigue. There
mised clinical trial of adjunctive psychological therapy    are also a number of other important considerations
(APT) in women with breast cancer. APT is based on          such as the degree of sedation required, safety in over-
the cognitive model of depression developed by Beck         dose, and the effects on psychomotor performance
in the United States. Depression, and anxiety, are seen     (which might effect driving) and other aspects of role
as maladaptive secondary emotional responses to             functioning (e.g., being able to look after young chil-
faulty modes of thinking, and therapy aims to correct       dren).
these modes of thinking with a view to alleviating the
emotional distress. APT also involves the use of vari-          PSYCHOLOGICAL FACTORS, DISEASE
                                                                     ONSET, AND PROGNOSIS
ous other techniques based on the behavioural ap-
proach. One hundred seventy-four patients, the ma-             It has long been suspected that psychological fac-
jority of whom had breast cancer, and all of whom           tors may predispose to cancer and influence its subse-
showed evidence of psychological morbidity, took            quence course. Almost 2,000 years ago, the Greek
part in the study. Patients who had received APT were       physician Galen suggested that individuals with a mel-
significantly less likely at 4-month follow-up to be        ancholic temperament were more likely to develop
suffering from severe anxiety (20%) compared with           cancer than those who were sanguine. More recently,
43%). However, a differential effect was not seen for       in 1870, James Paget observed in his Surgical Pathol-
borderline or severe depression (control patients also      ogj. [29] that “The cases are so frequent in which deep
improved). This is a very important study, and further      anxiety, deferred hope, and disappointment are
 trials to evaluate similar interventions should be car-    quickly followed by the growth and increase of cancer
ried out.                                                   that we can hardly doubt that mental depression is a
    Psychological interventions may be targeted specifi-    weighty addition to the other influences favouring the
cally at the side effects of treatment. In an uncon-        development of the cancerous condition.” Since then,
trolled study of 18 patients all of whom had severe         others have suggested that personality factors, mood
chemotherapy side effects (nausea, vomiting, and            and stressful live events are relevant to the induction
 treatment-related anxiety), and which included six pa-     and progression of the malignant process [30]. Al-
 tients with breast cancer, we found that progressive       though much of this literature is not specific to breast
muscular relaxation training, cue-controlled relaxa-        cancer, some studies have focused on this disease. For
 tion training, hypnotic suggestion, and a technique,       example, in an experimental study, Pettingale, Wat-
 which we called “nausea management training,” pro-         son, and Greer [31] showed that women with breast
 duced clinically beneficial improvements in nausea,        cancer were more emotionally inhibited and that they
 vomiting, and treatment-related anxiety. [26] Others       became more anxious than healthy women when
 have also found these methods to be of value. In a         stressed. Moreover, the same group found that atti-
 subsequent randomised, prospective controlled trial, a     tude towards their cancer was a significant predictor
 very low incidence of psychiatric disorder and side        of survival: women who adopted the “fighting spirit”
 effects was observed, not only in the patients receiving   or “denial” survived significantly longer than those
 the psychological intervention, but also in the control    who responded with helplessness, hopelessness or
 groups [27,28]. This appeared to be related to the in-     stoic acceptance [32]. Furthermore, attitude toward
 formation and support given to the patients during the     the illness appeared to have immunological correlates
 early part of their treatment and further underscores      that might have mediated these effects on survival [33].
 the importance of these variables in the management        Jensen [34] also found psychological factors were rele-
 of patients with cancer.                                   vant to outcome; neoplastic spread was related, for
    While some distress is almost inevitable, and indeed    example, to a repressive personality style, reduced ex-
 may even be desirable (particularly at diagnosis), it is   pression of negative emotions and feelings of helpless-
 important to identify a level of distress which meets      ness and hopelessness.
 diagnostic criteria for clinically significant problems.      Work in other cancers has also suggested that psy-
 When such criteria are met, there is evidence that ap-     chological factors may have independent prognostic
 propriate psychological and/ or psychopharmacologi-        significance. For example, in a recent study of patients
 cal interventions (e.g., antidepressant medication)        with Hodgkin’s disease and non-Hodgkin’s lym-
 should be used as many of these patients benefit con-      phoma, we found that patients with borderline or
 siderably. If a psychopharmacological approach is          clinically significant depression at diagnosis and a high
                                                                        Psychological Assessment and Interventions 81

 score on the L-scale of the Eysenck Personality Inven-      cancer who were rated as well adjusted, who reported
 tory (which, in this context, is probably a measure of      less than desirable social support and who responded
 social conformity) were much more likely to die dur-        with fatigue-like symptoms tended to have lower natu-
ing the five years after diagnosis [35]. Moreover, mul-      ral killer (NK) cell activity. NK activity has been
tivariate analysis using the Cox proportional hazards        shown in animals to be important in preventing tu-
method indicated that these variables had independent        mour cell dissemination and the formation of metas-
prognostic significance. Much further work requires          tases [40]. Moreover, Grossrath-Maticek and Eysenck
 to be done before it can be concluded that there is a       [41J studied 50 patients with metastatic breast cancer.
 causal relationship between psychological factors and       All received chemotherapy, and one-half were also
 survival, but the results of these studies are suggestive   given a psychological intervention. Women who had
 and, if confirmed, open up new therapeutic opportuni-       the psychological treatment survived longer and, in
 ties.                                                       addition, had higher lymphocyte counts following
    Perhaps the most exciting possibility is that psycho-    chemotherapy. In a prospective, randomised con-
logical interventions, in addition to improving quality      trolled study of patients with malignant melanoma,
of life, may also be able to enhance survival. Spiegel et    Fawzy et al. [42] showed that a brief psychoeduca-
al. [36] reported a 10-year follow-up of 89 women with       tional intervention increased the percentage of large
locally advanced breast cancer. Some had received a          granular lymphocytes (NK cell subpopulation) and
psychosocial intervention in a group setting and these       enhanced the NK cytotoxic activity of blood lym-
women lived significantly longer than the control pa-        phocytes. Psychoneuroimmunology, although still in
tients. Positive findings have also been reported in         its infancy, is likely to be an important aspect of future
patients with malignant melanoma and lymphoma                breast cancer research [43].
[35].However, much further work will be required to             The possible etiological importance of life events
confirm or refute the hypothesis that psychosocial in-       has not been clearly established. Loss events, for ex-
terventions can enhance survival. If they can, it will be    ample bereavement, have been implicated by some
important to characterise the psychobiological factors       clinicians and have been shown to induce cellular im-
(e.g., type and stage of tumour, and personality char-       mune suppression (e.g., reduced in vitro response of
acteristics) that predict a satisfactory response to such    blood lymphocytes to mitogens). Because it is cur-
interventions.                                               rently not possible to identify the exact timing of the
    If psychosocial factors can prolong survival, the ob-    onset of malignant disease and its stage in individual
vious question is “how?” One possibility is that it may      cases, it is not possible to establish a precise causal
act via psychoneuroimmunological mechanisms.                 relationship. The situation is somewhat simpler, how-
There is increasing evidence, in animal studies and in       ever, with respect to life events and relapse of disease
human subjects, that various stressors have im-              in patients with established and treated malignancy. In
munosuppressive effects. Moreover, there is some evi-        a case controlled study, Ramirez et al. [44] found that
dence that psychosocial interventions can moderate           severe life events and severe difficulties were signifi-
this suppression, particularly in healthy volunteers.        cantly associated with increased incidence of tumour
Kiecolt-Glaser et al. [37] demonstrated immunosup-           recurrence. However, negative findings have also been
pression in medical students during the month prior to       reported.
an important examination. Moreover, they found that
those volunteers who had practised relaxation during                   ORGANISATION OF SERVICES
this period were less adversely effected. In a small            On the basis of existing evidence, it is abundantly
randomised, controlled study, we found that subjects         clear that the psychosocial dimension of patient care is
who practised special relaxation exercises daily for         extremely important in terms of quality of life and that
three week had significantly lower systemic levels of        it may also be significant in terms of disease progres-
interleukin-1 and showed reduced in vitro responsive-        sion. This raises important organisational issues as to
ness of blood lymphocytes to the mitogen phytoha-            who should provide the psychosocial support, what
emagglutinin [38]. Volunteers in both groups were            support should be provided, which patients should
subsequently exposed to a stressful experience pre-          receive it, and what training is required for those pro-
ceded by a hypnotic induction for the volunteers who         viding this support. In the United Kingdom, many
had learned relaxation. Interleukin- 1 levels and mito-      centres have appointed breast care specialists who are
gen responsiveness quickly returned to baseline levels       usually nurses by training. However, it appears that
following exposure to this experimental stressor.            many have received no specific training in the identifi-
    Little work has been done in breast cancer. How-         cation of psychiatric morbidity and have been given
ever, Levy et al. [39] showed that patients with breast      inadequate training in basic counseling skills. Several
82 Walker and Eremin

training courses have been established: the Manches-                 5. Paraskevaidis E, Kitchener HC, Walker LG: Doctor-patient
                                                                        communication and subsequent mental health in women with
ter courses in particular continue to be thoroughly                     gynaecological cancer. Psycho-Oncology 2: 195-200, 1993.
evaluated in terms of their immediate effects on per-                6. Fallowfield LJ. Clark A: “Breast Cancer.” London: Rout-
formance as well as their impact in the longer term                     ledge, 1991.
when counselors return to their own working environ-                 7. Hogbin B. Fallowfield LJ: Getting it taped: The “bad news”
                                                                        consultation with cancer patients. Br J Hosp Med 41:330-333,
ments. However, further research is required to clarify                 1989.
how best counsellors should be selected, trained, and                8. Maguire P: Improving the detection of psychiatric problems in
organised. As already indicated, it is importance of                    cancer patients. SOCSci Med 20:819-823, 1985.
                                                                     9. Zigmund AS, Snaith RP: The Hospital Anxiety and Depres-
provide an appropriate support network to prevent                       sion Scale. Acta Psychiatr Scand 67:36l-370. 1983.
“burn-out” and to maintain new skills learned during                10. De Haes JCJM, Pruyn JFA, Knippenberg FCE: Klachtenliist
training.                                                               voor kankerpatienten. Eerste ervaringen.Neder Tijdschr Psy-
                                                                        chol 38:403-422. 1983.
   Fallowfield and colleagues have developed an excit-              11. Aaronson NK, Ahmedzai S, Bergman B, et al: The European
ing, innovative training programme for senior oncol-                    Organisation for Research and Treatment of Cancer QLQ-
ogy clinicians. This “top-down” approach recognises                     C30: A quality of life instrument for use in international clini-
                                                                        cal trials in oncology. J Natl Cancer Inst 85:365-376, 1993.
the importance of senior oncologists as role models for             12. Morrow GR. Chiarello RJ, Derogatis LR: A new scale or
more junior staff. Evaluation questionnaires show                       assessing patients’ psychological adjustment. Psycho1 Med
high levels of satisfaction by participants. An ongoing                 8:605-610. 1978.
                                                                    13. Ware JE, Sherbourne CD: The MOS 36-item short form health
study in Aberdeen is evaluating the possible merits of                  survey (SF-36): conceptual framework and item selection. Med
cancer patient participation in communication skill                     Care 30:473-483, 1993.
training programmes for medical undergraduates [45].                14. OBoyle CA. McGee HM, Hickey A, et al: Individual quality
                                                                        of life in patients undergoing hip replacement. Lancet 339:
The initial results show that there are positive attitudi-               1088-1091. 1991.
nal changes in students taught on patients with cancer,             15. Maguire P, Tait A, Brooke M, et al: The effect of counselling
as opposed to those taught on other general hospital                    on the psychiatric morbidity associated with mastectomy. BMJ
inpatients. However, it will be important to see if these               281:1454-1456, 1980.
                                                                    16. Walker LG. Walker MB. Wesnes KA, et al: The psychological
attitudinal change are maintained in the final year of                  and psychiatric effects of rIL-3 in patients with advanced colo-
the course and, critically, whether or not the interview                rectal cancer: A controlled trial. Br J Surg 81:749-780, 1994.
performance of students taught on patients with can-                17. Dean C. Roberts MM, French K, Robinson S: Psychiatric
                                                                        morbidity after screening for breast cancer. J Epidemiol Com-
cer are better at this stage.                                           munity Health 40:71-75. 1986.
                                                                    18. Ellman R. Angeli N , Christians A, et al: Psychiatric morbidity
                   CONCLUSIONS                                          associated with screening for breast cancer. Br J Cancer 60:
                                                                        781-784. 1989.
   Psychosocial, or behavioural, oncology is a rela-                19. Bull AR, Campbell MJ: Assessment of the psychological im-
tively new discipline. It is already evident that a great               pact of a breast screening programme. Br J Radio1 64:5 10-515,
deal can be done to enhance the quality of life of                  20 Cockburn J. Staples M, Hurley SF, De Luke T: Psychological
patients with breast cancer and to minimise the risk of                 consequences of screening mammography. J Med Screen 1:7-
psychiatric disorder. However, much remains to be                        12, 1994.
                                                                    21 Walker LG. Cordiner CM, Gilbert FJ. et al: How distressing
done to develop and refine these techniques and to                      is attendance for routine breast screening? Psycho-Oncology
explore the possibility that they may have independent                   3:299-304. 1994.
prognostic significance for survival, as well as psycho-            23 Gilbert FJ. Cordiner CM, Affleck IR. et al: How anxiogenic is
                                                                        recall following breast screening, and does a family history of
logical benefits. It is important that oncologists are                  breast cancer make a difference? Psycho-Oncology 4:88, 1995.
aware of this research as they are in an ideal position             23 Lynch HT. Lynch J. Conway T, Severin M: Psychological
to prevent and ameliorate at least some of the adverse                  aspects of monitoring high risk women for breast cancer. Can-
                                                                        cer 74 (suppl): 1184-1 193, 1994.
impact of the diagnosis and treatment of breast can-                24 Cull A. Anderson E, Mackay J, et al: The effect of attending
cer.                                                                     a breast cancer family clinic on women’s estimates of risk and
                                                                         levels of psychosocial distress. Psycho-Oncology 495, 1995.
                     REFERENCES                                     75. Grew S. Moorey S, Baruch JDR, et al: Adjuvant psychological
                                                                         therapy for patients with cancer: A prospective randomised
   Maguire GP, Lee EG, Bevington DJ, et al: Psychiatric prob-            trial. BMJ 304:675-680, 1992.
   lems in the first year after mastectomy. BMJ 1:963-965, 1978.    36. Walker LG, Dawson AA, Pollet SM, et al: Hypnotherapy for
   Irvine RN, Brown B, Crooks D, et al: Psychosocial adjustment         chemotherapy side-effects. Br J Exp Clin Hypnosis 5:79-82,
   in women with breast cancer. Cancer 67:1097-1I17. 1991.               1988.
   Fallowfield LJ, Baum M. Maguire GP: Effects of breast con-       27. Walker LG: Hypnosis and cancer. Am J Prev Psychiatry Neu-
   servation on psychological morbidity associated with the diag-        rol 3:42-49, 1992.
   nosis and treatment of early breast cancer. BMJ 293:1331-        28. Walker LG, Lolley . , IDawson AA, Ratcliffe MA: Hypnother-
   1334. 1986.                                                           apy for chemotherapy side effects: Further developments. In
   Dean C, Chetty U, Forrest APM: Effects of immediate breast            Heap M (ed): “Hypnotic Contributions.” Sheffield: BSECH
   reconstruction on psychological morbidity after mastectomy.           Publications, 1991, 63-71.
   Lancet 1:459-463. 1983.                                          29. Cox T, Mackay C: Psychosocial factors and psychophysiologi-
                                                                                     Psychological Assessment and Interventions 83

      cal mechanisms in the aetiology and development of cancer.        38. Walker LG, Johnson VC, Whiting PH, et al: Relaxation train-
      SOCSci Med 16:381-396, 1982.                                          ing and modulation of the immune rewsponse to stress. Br J
30.   Eysenck HJ: Cancer, personality and stress: Prediction and            Cancer 67(suppl xx):66, 1993.
      prevention. Adv Behav Res Ther 16:167-215, 1994.                  39. Levy SM, Herberman RB, Maluish AM, et a]: Prognostic risk
31.   Pettingale K, Watson M. Greer S: The validity of emotional            assessment in primary breast cancer by behavioural and im-
      control as a trait in breast cancer patients. J Psychosoc Oncol       munological parameters. Health Psychol 4:99-113, 1985.
      2 2 130, 1984.                                                    40. Robertson MJ, Ritz J: Biology and clinical relevance of human
32.   Greer S. Morris T Pettingale KW, Haybittle JL: Psychological          NK cells. Blood 76:2421-2428, 1990.
      response to breast cancer and 15 year outcome. Lancet 335:49-     41. Grossrath-Maticek R, Eysenck HJ: Length of survival and
      50, 1990.                                                             lymphocyte percentage in women with mammary cancer as a
33.   Pettingale KW, Greer S, Dudley EHT: Serum IgA and emo-                function of psychotherapy. Psychol Rep 65:315-321, 1989.
      tional expression in breast cancer patients. J Psychosomat Res    42. Fawzy FI, Kemeny ME, Fawzy NW, et al: A structured psy-
      21 :395-399, 1977.                                                    chiatric intervention for cancer patients. 11. Changes over time
34.   Jensen MR: Psychobiological factors predicting the course of          in immunological measures. Arch Gen Psychiatry 47:729-735,
      breast cancer. J Personality 55:317-342, 1987.                        1990.
35.   Ratcliffe MA, Dawson AA, Walker LG: Eysenck personality           43. Walker LG, Eremin 0: Psychoneuroimmunology: A new fad
      L-scores in patients with Hodgkin’s disease and non-Hodg-             or the fifth cancer treatment modality? Am J Surg 170:2-4,
      kin’s lymphoma. Psycho-Oncology 4:39-45, 1995.                        1995.
36.   Spiegel D, Kraemer HC, Bloom JR, Gottheil E: Effect of psy-       44. Ramirez AJ, Craig TK, Watson JP, et al: Stress and relapse in
      chological treatment on survival of patients with metastatic          breast cancer. BMJ 298:291-293, 1989.
      breast cancer. Lancet 2:888-891, 1989.                            45. Klein S, Kitchener HC. Walker LG: Does cancer patient par-
37.   Kiecolt-Glaser JK, Glaser R, Strain EC, et al: Modulation of          ticipation in communication skills training enhance the per-
      cellular immunity in medical students. J Behav Med 9:5-21,            formance of medical undergraduates. Psycho-Oncology 4:90.
      1986.                                                                 1995.