Documents
Resources
Learning Center
Upload
Plans & pricing Sign in
Sign Out

IV Antibiotic therapy; Cost relative to Ceftriaxone 1gday;

VIEWS: 314 PAGES: 4

IV Antibiotic therapy; Cost relative to Ceftriaxone 1gday;

More Info
									March 2008 PostScript 44 Antimicrobial Team Supplement

Sepsis criteria

 Sepsis is defined as
    • Clinical symptoms of infection (fever, sweats, chills or rigors, malaise, etc.) or proven infection
    • and at least two of the following:
       temperature >38oC or <36oC
       tachycardia >90 bpm
       tachypnoea: respiratory rate >20/min
       WCC <4 or >12 x 10 6 cells/ml

 Serious or severe sepsis
  Sepsis with
  • organ dysfunction or,
  • hypotension (systolic BP < 90mmHg, reduction of 40mm Hg from baseline ) or,
  • hypoperfusion (lactic acidosis, oliguria, or confusion)
ALERT Antibiotics
IV Antibiotic therapy; Cost relative to ceftriaxone 1g/day;

                                                                1 days IV antibiotic Hospital cost relative to ceftriaxone 1g od Dec 2007


                            120




                            100




                              80




                              60




                              40




                              20




                               0
                                   Linezo Clinda Tigecy Dapto Merop Ertape Tazoci Teicop Clarith Vanco Fluclo Ciprofl Co- Cefota Benzyl Fluclo Cefota Genta Ceftria Amoxi Metron Ceftria
                                     lid mycin cline mycin enem nem n 4.5g lanin romyci mycin xacillin oxacin amoxi xime penicill xacillin xime micin xone cillin idazol xone
                                   600mg 900mg 50mg 350mg 1g tid 1g od tid 400mg n 1g bd 2g qid 400mg clav 2g tid in 1.2g 1g qid 1g tid 320mg 2g od 1g tid e 1g od
   cost relative to ceftriaxone 1g od 115.58 85.883 83.896 70.13 66.974 50.571 49.208 36.364 27.558 7.4026 7.3766 6.8831 4.6753 4.2078 4.1558 3.6623 3.1169 2.0779   2   1.6364 1.1688   1


NB: this table is for cost comparison of IV antibiotics only. Drugs and doses listed do not imply equivalence.
Oral Antimicrobial costs relative to doxycycline 100mg/day;

 AGENT                       Relative cost to doxycycline (Xs)
 Linezolid 600mg bd          1947
 Famciclovir 500mg tid       1031
 Famciclovir 750mg od        515
 Valaciclovir 1g tid         264
 Vancomycin 125mg qid        174
 Clindamycin 600mg tid       147
 Clindamycin 450mg tid       110
 Sodium Fusidate 500mg tid   79
 Rifampicin 450mg bd         21
 Clarithromycin 500mg bd     14
 Rifampicin 300mg bd         14
 Flucloxacillin 1g qid       12
 Aciclovir 800mg 5x daily    11
 Nitrofurantoin 50mg qid     9
 Co-amoxiclav 625mg tid      8
 Penicillin V 1g qid         8
 Ciprofloxacin 750mg bd      5
 Co-amoxiclav 375mg tid      5
 Penicillin V 500mg qid      4
 Amoxicillin 1g tid          3
 Trimethoprim 200mg bd       3
 Ciprofloxacin 500mg bd      3
 Doxycycline 100mg bd        2
 Metronidazole 400mg tid     2
 Amoxicillin 500mg tid       2
 Doxycycline 100mg od        1


NB: this table is for cost comparison of antibiotics and antivirals only. Drugs and doses listed do not imply equivalence.

								
To top