LIPID LOWERING DRUGS
I.
HMG- CoA reductase inhibitors / Statins atorvastatin (Lipitor) simvastatin (Zocor) pravastatin MOA: inhibits HMG- CoA reductase inhib. Cholesterol synthesis SE/ Adverse effects: 1. GIT upset 2. liver complications 3. rhabdomyolysis 4. cataract CI: liver failure, pregnancy & lactation, allergy to fungal byproducts LDL
II.
Bile Acid sequestrants cholestyramine colestipol MOA: binds bile acids in SI & promote increase disposal of cholesterol SE: 1. 2. 3. 4.
CNS effects: HA, anxiety, drowsiness GIT effects: nausea ,constipation, bloating & flatulence increase bleeding muscle aches & pains
III.
Fibrates gemfibrozil clofibrate MOA: decrease triglyceride & LDL synthesis SE: 1. same GIT effects 2. muscle aches & pains TG & LDL, HDL
IV.
Nicotinic Acid / Vitamin B3 / Niacin MOA: 1. inhib. release of fatty acids from adipose tissue 2. increase TG removal from plasma TG & LDL, HDL
SE: 1. intense flushing, dizziness, fainting 2. GIT effects: nausea, abdominal pain