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					                      Muhammad Saleem, Ph.D.
                  Department of Chemistry, Baghdad-ul-Jadeed Campus
                     The Islamia Univerisyt of Bahawalpur, Pakistan
                                 Phone # 0302-7710708
                            E-mail: drsaleem_kr@yahoo.com


PERSONNELS

Name                             Muhammad Saleem
Father’s name                    Muhammad Sadiq
Date of Birth                    10th. August 1970
N.I.C. No.                       42201-0637460-3
Domicile                         Lodhran, Pakistan
Marital Status                   Married
Nationality                      Pakistani



PRESENT POSITION
      HEC Approved Supervisor
      Working as Assistant Professor in the department of Chemistry, The Islamia University
       of Bahawalpur.
      Team leader of M. Phil. And Ph. D. Rsearch students with 5 indegenous scholors.

ACADEMICS

Postdoctoral Studies (2006): Alexander Von Humboldt Fellow at University of
Goettingen, Germany.
Topic of Research: Novel anticancer compounds from marine derived Organisms

Postdoctoral Studies 2003-2005: Korea Organization of Science and Engineering
Foundation (KOSEF) fellow at Korea institute of Science and Technology (KIST), Seoul,
South Korea.
Topic of Research: Development of Anti-oxidative Neuroprotective Neutralecuticals agents
and anti-HIV integrases from higher plants.

Ph. D. Chemistry 1997-2000: H.E.J. Research Institute of Chemistry, International
Center for Chemical Sciences (ICCS), University of Karachi, Pakistan.
Title of Thesis: Chemical and Biological screening of relatives of the Family Lamiaceae
(Labiatae) and Marine Green Alga Codium iyengarii.

M.Sc. Chemistry 1995-1997: Islamia University Bahawalpur, Pakistan.
Title of Thesis: Isolation of Coumarines from the Leaves of Citrus Aurantifolia.

Bachelors in Science 1992-1994: The Islamia University of Bahawalpur, Pakistan.
Major Subjects: Chemistry, Botany, Zoology.
                                               1
RESEARCH/PROFESSIONAL EXPERIENCE

At Present: Working as Assistant Professor in Chemistry Department of The Islamia
University Bahawalpur, Pakistan

2006 to Feb 2007 Postdoctoral Research: Institute for Organic and Biomolecular
Chemistry The Georg-August-University, Göttingen, Germany
Topic: Novel anticancer compounds from marine derived Organisms

2004 to 2005, Visiting Scientist: Medicinal Chemistry Research Center, Division of Life
Sciences, Korea Institute of Science and Technology (KIST), Seoul, South Korea
Topic: Development of Anti-oxidative Neuroprotective Neutralecuticals agents and anti-HIV
integrases from higher plants.

2003 to 2004, Postdoctoral Research: Medicinal Chemistry Research Center, Division
of Life Sciences, Korea Institute of Science and Technology (KIST), Seoul, South Korea.
Topic: Development of Anti-oxidative Neuroprotective Neutralecuticals agents from higher
plants.

2001-2003 Senior Scientific Officer: Pharmaceutical Research Center, PCSIR Labs
Karachi, Pakistan
Responsibilities: Involved in R&D programs and carry out projects as development of
hormonal precursors, Cosmaceutical agents, Essential oils and their evaluations, laboratory
managements and Industrial analysis.

2000-2001 Scientific Officer: Pharmaceutical Research Center, PCSIR Labs Karachi,
Pakistan
Responsibilities:: Involved in R&D programs and carry out projects, laboratory managements
and Industrial analysis

1997-2000 Junior Research Fellow: H.E.J. Research Institute of Chemistry, University
of Karachi, Pakistan.
Title: Chemical and Biological screening of some Members of the Family Lamiaceae
(Labiatae) and Marine Green Alga Codium iyengarii

1994-1996 M.Sc. Thesis: Department of Chemistry, Islamia University Bahawalpur,
Pakistan.
Topic: Isolation of Coumarines from the Leaves of Citrus aurantifolia.

TEACHING EXPERIENCE
      Assistant Professor in the Department of Chemistry, The Islamia University of
       Bahawalpur since July 2007.
      Prepared and taught a full course to MS and PhD students of International Research and
       Development Academy at Korea Institute of Science and Technology (KIST), Seoul,
       Korea

                                              2
SCHOLARSHIPS AWARDED AND DISTINCTIONS

 Merit scholarship from directorate of colleges Bahawalpur Division on passing B.Sc.
  examination with excellence.
 Research Fellowship from H.E.J.(1997 to 2000)
 Distinction Certificate in M. Sc. Examination, 1997.
 Korea Science and Engineering Foundation (KOSEF) Postdoctoral Fellowship for one year,
  2003.
 Two years Postdoctoral Fellowship from Korea Institute of Science and Technology, Seoul,
  South Korea, 2004-2005.
 One year Postdoctoral Fellowship from Alexander von Humboldt Foundation, Germany,
  2006-2007.

PRESENTATIONS/LECTURES
 A 15-minute talk on Constituents of Zataria multiflora in 9th.National Chemistry
  Conference held at Karachi, Pakistan
 A 60-minute talk on The Use of Chiral Boron Complexes in Asymmetric Organic
  Synthesis as per Ph.D. requirement.
 A 60-minute talk on Total Synthesis of (+)- Acutiphycin and a Related Compound as per
  Ph.D. requirement.
 A 60-minute talk on Ph.D. work as per Ph.D. requirement.
 A poster entitled, "Marine Chemistry" presented in 7th. Eurasia conference held in Karachi,
  Pakistan on 09-03-2002-12-03-2002.
 Delivered a lecture on "Column selection and protection in reversed phase
  chromatography" in a trainee course at PCSIR Labs. Karachi arranged by Pakistan Council
  of Science and Technology during 26-03-2002 to 30-03-2002.
 A 30 minutes talk on “chemical constituents of Parthenocissus tricuspidata and their
  antioxidant evaluation” Korea-Magnolia second workshop of Biotechnology held at Korea
  Institute of Science and Technology (KIST), Seoul, Korea on 10-05-2004 to 12-05-2004.
 Taught a full course on Natural Product chemistry at International Research and
  Development Academy (IRDA), Seoul, Korea
 Delivered a 90 minute seminar on Natural product Chemistry and Drug development and
  utilization of Analytical techniques in Pharmaceutical Analysis at Department of Pharmacy,
  Faculty of Science, Islamia University Bahawalpur, Pakistan.
 15 minute talk on “Novel Bioactive Compounds from Marine Bacteria” delivered at
  University of Bonn, Germany on 26th April 2006 during International meeting of AvH
  fellows from 25th to 27th April 2006.
 A 90 minutes lecture delivered on “Folding Modes in Biosynthesis of Fused Ring
  Polyketides, A comparison of Fungal and Bacterial Metabolites with that of Higher Plants”
  at Natural product Section of the Institute of Organic and Biomolecular Chemistry,
  University of Goettingen, Germany.




                                             3
SEMINAR, CONFERENCES AND WORKSHOPS ATTENDED
 Workshop on the Use of Bioassay Techniques for New Drug Development held at H.E.J.
  Research Institute (8th. July 1997).
 7th. International Symposium on Natural Product Chemistry held at Karachi
  (28th.December-1st.January 1998).
 9th.National Chemistry Conference held at Karachi (6-8th.December 1998)
 2nd.National Workshop on The Use of Bioassay Techniques for New Drug Development
  held at H.E.J. University of Karachi (26-28th. August 1999)
 8th. International Symposium on Natural Product Chemistry held at Karachi (18th. -22nd.
  January 2000).
 Workshop on, "Information handling in Biological Research" held at Biochemistry
  Department, University of Karachi (4th. - 6th. March 2002).
 7th. Eurasia conference on Chemical Sciences held at Hotel Marriott, Karachi, Pakistan on
  09-03-2002 to 12-03-2002.
 International Symposium on “Inflammatory and Oxidative Cell Death and Tissue Damage;
  Molecular Mechanism, Biomarkers and Chemoprevention” held at Seoul National
  University, Seoul, Korea (2004).
 Korea-Magnolia second workshop of Biotechnology held at Korea Institute of Science and
  Technology (KIST), Seoul, Korea on 10-05-2004 to 12-05-2004.
 Took active part in International meeting of AvH fellows held at Bonn Germany from 25 th
  to 27th April 2006.
 Alexander von Humboldt Network meeting held at Hotel Marriott, Islamabad, Pakistan on
  28th of March 2007.

OTHER SKILLS
Experience in conducting the following Bioassays of Chemicals and Plant extracts:
    Anti Bacterial Bioassay, Antifungal Bioassay, Insecticidal Bioassay, Phytotoxic
      Bioassay, Brine shrimp Bioassay and Enzyme inhibition Bioassay.

ANALYTICAL/MICROBIOLOGICAL CHEMISTRY SKILLS
      Experience in working with HPLC, IR, UV, POLARIMETERY, and NMR techniques
      Experience in conducting bioassays with microbial agents, making sub-cultures,
       fermentation and optimizations by biotransformation and culturing procedures.

COMPUTER LITERACY
Proficient in working with: Microsoft Word, Microsoft PowerPoint, Chem. window, Chem.
Draw, ISIS Draw, ACD lab., Excel and Internet Tools.

TRAININGS OBTAINED
 Attended trainee courses of ISO-9001 held at PCSIR Labs complex Karachi, Pakistan.
 Attended trainee courses of ICE/ISO-17025 held at PCSIR Labs. Complex Karachi,
  Pakistan.




                                            4
RESEARCH INTERESTS

          Development of Anti-oxidative Neuroprotective Neutralecuticals agents and anti-
           HIV integrases from higher plants: Alkaloids, coumarines, flavonoids and lignans.
          Chemical and Biological studies on marine algae.
          Isolation, characterization and biological evaluation of terpenoids and steroids
           obtained from medicinal herbs.
          Isolation and spectroscopic analysis of new antibiotics from microbial sources, and
           optimization of active new chemicals by biotransformation and culturing
           procedures.


PATENTS
1. S. Anjum, M. Saleem, N. Afza, M.A. Kalhoro and S.M.A. Hai, Production of
   "Medicinally Important Diosgenin" from Dioscorea bulbifera available in Pakistan,
   513/2001, SI No 137729, Government of Pakistan Karachi Office.
2. M. Saleem, S. Perveen, R.A. Khan and N. Afza, "Process for the Production of Skin Caring
   Cream of pH 5.5", 427/2002, SI No 138106, Government of Pakistan Karachi Office.
3. Nighat Afza, Muhammad Saleem, Mahboob Ali Kalhoro and Muhammad Aijaz Anwar, A
   Process for the Development of an Herbal Inhaler and Cream for the Treatment of Blocked
   Sinuses, Asthma, Bronchitis, Cough and Cold and other Respiratory Tract Diseases,
   800/2003, SI-138571, Government of Pakistan Karachi Office.


TECHNICAL REPORTS




                                              5
              List of Publications of Dr. Muhammad Saleem
Year 2008

   1. Muhammad      Shaiq   Ali,   Shakil   Ahmed   and   Muhammad     Saleem    (2008),
      Spirowallichiione: A Rearranged Multiflorane from Euphorbia wallichii Hook
      F. (Euphorbiaceae). Molecules 2008, 13, (accepted for publication).

   2. Hafizur Rahman, Mohamed Shaaban, Khaled A. Shaaban, Muhammad Saleem,
      Elisabeth Helmke, Iris Grün-Wollny, and Hartmut Laatsch, Secondary Metabolites
      from Streptomycetes B7967 and GW 5127. (Submitted to Natural Product
      Communication, 2008).
   3. Muhammad Saleem, Zhang Qun, Qin Song, and Hartmut LaatschHuanghaimycin, a
      new macrolide, and Chloenolaene, a chlorinated pyrane derivative, from the marine-
      derived Streptomycete L196. (Submitted to Journal of Natural Products, 2008).
   4. Muhammad Saleem, Hafizur Rahman, Gerhard Wolf, and Hartmut Laatsch, Secondary
      Metabolites from Terrestrial Actinomycetes Wo1. (Submitted to Natural Product
      Communication, 2008).
   5. Muhammad Saleem, Gerhard Wolf and Hartmut Laatsch, Secondary Metabolites from
      a Terrestrial Actinomyces sp. Wo 23. (Submitted to Natural Product Communication,
      2008).
   6. Qun Zhang, Muhammad Saleem, Fuchao Li, Song Qin, Hartmut Laatsch, Isolation and
      Structure Determination of Antibacterial Secondary Metabolites from Marine-Derived
      Streptomyces sp. L158. (Submitted to Journal of Natural Products, 2008).
Year 2007
   7. Muhammad Saleem, Muhammad Shaiq Ali, Shaftqat Hussain, Abdul Jabbar,
      Muhammad Ashraf, Yong Sup Lee, Marine Natural products of Fungal Origin.
      Natural product Report (2007), 24, 1142-1152, (ISSN 0265-0568, Published in
      England)). Impact factor = 7.89.
   8. Muhammad Saleem, Hyoung Ja Kim, Changbae Jin and Yong Sup Lee. New
      antioxidant secondary metabolites from various parts of Parthenocissus
      tricuspidata. Pharmacy in New Era, 1st National Pharmacy Conference held at
      Faculty of Pharmacy and Alternative Medicine, The Islamia University of
      Bahawalpur on March 02-04, 2007 (abstract published).
Year 2006
   9. Muhammad Saleem, Hyoung Ja Kim, Chang Kyun Han and Changbae Jin, Yong Sup
      Lee (2006), New secondary metabolites from Opuntia ficus-indica var. saboten.
      Phytochemistry (ISSN: 0031-9422, Published in England) 67(13), 1390-4. Impact
      factor = 2.780
   10. M. Shaiq Ali, Waqar Ahmed and M. Saleem (2006), Longifoamide-A and B: Two new
       ceramides from Mentha longifolia (Lamiaceae), Nat. Prod. Research (ISSN: 1478-
       6419, Published in England)), 20(10), 953-60. Impact factor = 0. 572.

Year 2005
   11. Muhammad Saleem, Nighat Afza, M. Aijaz Anwar, Syed Muhammad Abdul
       Hai and Muhammad Shaiq Ali (2005): Aromatic Constituents from Fruit Peels
                                               6
      of Citrus reticulata, Nat. Prod. Res. (ISSN 1478-6419, Published in England),
      19 (6), 633-638. Impact factor = 0. 572
   12. Muhammad Saleem, Hyoung Ja Kim, Muhammad Shaiq Ali and Yong Sup
       Lee (2005): An Update on Bioactive Lignans. Natural Product Reports (ISSN
       0265-0568, Published in England), 22 (6), 696-716. Impact factor = 7.89
   13. Hyoung Ja Kim, Muhammad Saleem, Seon Hee Seo, Changbae Jin, and Yong
       Sup Lee (2005): Two New Antioxidant Stilbene Derivatives, Parthenostilbenins
       A and B from Parthenocissus tricuspidata. Planta Medica, (ISSN 0032-0943,
       Published in Germany), 71, 973-976. Impact factor = 2.289
   14. M. Shaiq Ali, Waqar Ahmed and M. Saleem (2005), Longifoside-A and B: Two
       new cerebrosides from Mentha longifolia (Lamiaceae), Nat. Prod. Research.,
       (ISSN 1478-6427, Published in England) (Online) 1–9. Impact factor = 0. 572.
   15. Yong Sup Lee, Hyoung Ja Kim, Kyung Ja Jung, Muhammad Saleem,
       Jungsook Cho, Changbae Jin (2005), Neuroprotective Anti-oxidative Flavonoids
       Isolated from Opuntia ficus indica var. saboten. 11th Asian Cheical Congress for
       the Quantum Leap of Asian Chemistry, Korea University, South Korea, August
       24-26. Page 108. Chemical Abstract
Year 2004
   16. Muhammad Saleem, Hyoung Ja Kim, Changbae Jin and Yong Sup Lee (2004):
       Antioxidant Caffeic acid Derivatives from Leaves of Parthenocissus tricuspidata.
       Archives of Pharmacal Research (ISSN: 0253-6269, Published in South Korea), 27 (3),
       300-304. Impact factor = 0.818
   17. Ali, M. S., Pervez, M. K., Ahmed, F. and Saleem, M. (2004): Dichotenol-A, B
       and C: The C-16 oxidized seco-dolastanes from the marine brown alga Dictyota
       dichotoma (Huds.) Lamour. Nat. Prod. Res. (ISSN: 1478-6419, Published in
       England) 18(6), 543-549. Impact factor = 0. 572
   18. Muhammad Saleem, Rahila Nazli, Nighat Afza, Amtul Sami and Muhammad
       Shaiq Ali (2004): Biological Significance of essential oil of Zataria multiflora
       Bioss. Nat. Prod. Res. (ISSN: 1478-6419, Published in England), 18 (6), 493-
       497. Impact factor = 0. 572
   19. Muhammad Saleem, Hyoung Ja Kim, Seon Hee Seo, and Yong Sup Lee
       (2004): Chemical Constituents of Parthenocissus tricuspidata and Their
       Antioxidant Evaluation. Proceedings, Second workshop on Korea-Mangolia
       Science and Technology cooperation, p 28-36, May 10-12. Proceedings
Year 2003
   20. Saleem, M. Afza, N., Anwar, M. A., Hai, S. M. A., Ali, M. S. Shujaat, S. and
       Rahman, A. (2003): Chemistry and Biological Significance of Essential Oils of
       Cymbopogon Citratus From Pakistan. Nat. Prod. Res. (ISSN: 1478-6419,
       Published in England), 17(3), 159-163. Impact factor = 0. 572
   21. Ali, M. S., Pervez, M. K., Saleem, M. and Ahmed, F. (2003): Dichotenone-A
       and B: Two new enones from the marine brown alga Dictyota dichotoma
       (Hudson) Lamour. Nat. Prod. Res. (ISSN: 1478-6419, Published in England), 17
       (5), 301. Impact factor = 0. 572


                                              7
   22. Saleem, M., Afza, N., Anwar, M. A., Hai, S. M. A. and Ali, M. S. (2003): A
       Comparative study of essential oils of Cymbopogon citratus and some members
       of the genus Citrus. Nat. Prod. Res. (ISSN: 1478-6419, Published in England),
       17, 369-373. Impact factor = 0. 572
   23. Ali, M.S., Jahangir, M., Saleem, M. (2003): Structural distinction between
       sabandin-A and B from Artemisia scoparia Waldst (Asteraceae). Nat. Prod. Res.
       (ISSN: 1478-6419, Published in England), 17(1), 1-4. Impact factor = 0. 572
Year 2002
   24. Ali, M.S., and Saleem, M. (2002): Role of the Family Lamiaceae in Human
       Life, Hamdard Medicus, (Published in Pakistan) XLV (2), 16-17.
   25. Kalhoro, M. A., Afza, N. Saleem, M. and Malik, A. (2002): Pharmacochemical
       studies of the oil, aerial parts, puep and peel of Citrullus colocynthis, J. Chem.
       Soc. Pak. (ISSN: 0932-0776, Published in Pakistan), 24, 274. Impact factor =
       0.173
   26. Ali, M.S., Saleem, M. Pervez, M. and Yamdagni, R. (2002): A chlorinated
       monoterpen ketone, acylated β-sitosterol glycosides and a flavone glycoside
       from Mentha longifolia (Lamiaceae). Phytochemistry, (ISSN: 0031-9422,
       Published in England) 59, 889-95. Impact factor = 2.780
   27. Ali, M. S., Saleem, M., Yamdagni, R. and Ali, M. A. (2002): Steroids and
       antibacterial steroidal-glycosides from marine green alga Codium iyengarii
       Borgesen. Nat. Prod. Lett. (ISSN: 1057-5634, Published in England), 16(6),
       407-413. Impact factor = 0. 572
Year 2001
   28. Ali, M. S., Saleem M. and Erian, A. W. (2001): A new acylated steroid
       glucoside from Perovskia atriplicifolia (Lamiaceae). Fitoterapia (ISSN: 0367-
       326X, Published in Netherlands), 72, 712-14. Impact factor = 1.042
   29. Ali,M.S., Pervez, M. K., Saleem, M. and Tareen, R.B. (2001): Haplophytin-A and B:
       The new alkaloidal constituents from Haplophyllum acutifolium. Phytochemistry
       (ISSN: 0031-9422, Published in England), 57, 1277-80. Impact factor = 2.780
   30. Ali, M. S., Saleem, M. and Ahmad,V. U. (2001): Phytol and glycerol
       derivatives from marine green alga Codium iyengarii of Karachi-coast (Arabian
       Sea). Z. Natureforsch. (ISSN: 0932-0776, Published in Germany), 56b, 837-41.
       Impact factor = 0.774
Year 2000
   31. Dar, A., Roome, T., Rezapour,F., Behanian, S., Sherkheli A., Choudhary,M.I.,
       Ali, S.A., Anjum,S., Ali, S., Swaleh, R., Rahman, A., Ali, M.S., Saleem, M. and
       Pervez, K. (2000): Preliminary Pharmacological Evaluation of Marine
       Organisms collected from Coastal Areas of Karachi, Proceedings of ONR
       National Symposium, 18-20 held at University of Karachi (Ed. V.U. Ahmad)
       Printed at Karachi University press, 1-10. Proceedings
   32. Ali, M. S., Mazhar, F., Saleem, M., Jahangir, M., Pervez, K., Usmanghani, K.
       and Ahmad , V. U. (2000): Algal bioactive chemical constituents, ONR
       Proceedings, 18-20 held at University of Karachi (Ed. V.U. Ahmad) Printed at
       Karachi University press, 33-44. Proceedings
                                               8
   33. Ali, M.S., Saleem, M. and Ahmad, V.U. (2000) Aromatic constituents of
       Zataria multiflora, Proceedings of 9th National Chemistry Conference, held at
       University of Karachi. Proceedings
   34. Ali, M.S., Dardass, A.Q.Y., Ahmed, S., Saleem, M., Firdous, S. and Ahmad,
       V.U. (2000): Two new diterpenoids from Salvia triloba. Fitoterapia (ISSN:
       0367-326X, Published in Netherlands), 71, 347-352. Impact factor = 1.042
   35. Ali, M.S., Saleem, M., Jahangir, M., Pervez, M.K., Hameed, S. and Ahmad,
       V.U. (2000): Metabolites of marine algae collected from Karachi coasts of
       Arabian Sea. Nat. Prod. Sci. 6 (2), 61-65.
   36. Ali, M. S., Saleem, M. Ali, Z. and Ahmad, V. U. (2000): Chemistry of Zataria
       multiflora ( Lamiaceae ). Phytochemistry (ISSN: 0031-9422, Published in
       England), 55(8), 933-936. Impact factor = 2.780
Year 1999
   37. Ali, M.S., Saleem, M. and Ahmad, V.U. (1999): Zetatriol: A new aromatic
       constituent from Zataria multiflora. Z. Natureforsch (ISSN: 0932-0776,
       Published in Germany), 54b, 807-810. Impact factor = 0.774
   38. Ali, M. S., Saleem, M., Akhtar, F., Jahangir, M., Parvez, M. and Ahmad, V. U.
       (1999): Three p-cymene derivatives from Zataria multiflora. Phytochemistry
       (ISSN: 0031-9422, Published in England), 52, 685-688. Impact factor = 2.780
   39. Ali, M.S., Jahangir, M., Saleem, M. and Ahmad, V. U. (1999): Chemical
       constituents of Pulicaria gnaphalodes. Nat. Prod. Sci. 5(3), 134-137.
Year 1997
   40. Jabbar, A, Saleem, M., Khan M.S. and Khatoon, T., J. (1997): Pure Appl. Sci.
       (Published in Pakistan), 16 (1), 1-4.
      Total publications                    40
      International Publications            30
      Local Publications                    10
      Papers in SCI Journals                11
      Patents                               03
      International Impact factor           41.234




                                            9
REFERNCES

M.Sc. Advisor
Dr. Abdul Jabbar (Professor)
Department of Chemistry, Islamia University, Bahawalpur
Pakistan

Ph.D. Advisor:
Dr. Muhammad Shaiq Ali (Associate Professor)
HEJ Research Institute of Chemistry, International Center for Chemical Sciences
University of Karachi, Pakistan
E-mail: shaiq303@hotmail.com and shaiq303@super.net.pk

Ex-Postdoctoral Advisor:
Dr. Young Sup Lee (Professor)
Department of Pharmaceutical Science, College of Pharmacy
Kyung Hee University, Dongdaemun-Ku, 1 Hoegi-Dong
Seoul 130-701, Korea
E-mail: kyslee@khu.ac.kr

Present Postdoctoral Advisor:
Dr. Hartmut Laatsch (Professor)
Institute for Organic an Biomolecular Chemistry, University of Göttingen,
Tammannstrasse 2, D-37077, Göttingen, Germany
Web: http://wwwuser.gwdg.de/~ucoc/laatsch/




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