Javad Behravan (Pharm.D., Ph.D.) Postdoctoral fellowship: Pharmacogenetics and Molecular Pharmacokinetics Associate Professor of Phar maceutical Biotechnology, School of Pharmacy; Head of Biotechnology Reseach Center, Mashhad University of Medical Sciences, IRAN Postal Address : School of Pharmacy, P. O. Box 91775-1365, Mashhad, IRAN. Phone: +98 511 8823255 Fax: +98 511 8823251 E-mail: email@example.com The main area of Dr. Behravan's research is Multi Drug Resistance (MDR) in cancer and normal tissue. He has been also involved in isolation and characterization of medicinal natural products from soil bacteria and endemic plants of Iran. Some efforts have been made to extend the research towards the application of those isolated natural products. In order to conduct more applied research, setting up of bioassay methods is at major concern. Recently, Agrobacterium tumefaciens potato-disc tumor system was adopted and modified and some projects are now underway to investigate tumor inhibition properties of microbial and plant extracts. Also some research is aimed at cloning the genes for pharmaceutically important proteins. Dr. Behravan is also interested in research on pharmacological receptors genetical polymorphism. The titles of some of his current projects includes: 1. Inflammatory breast cancer and MDR 2. Gene polymorphisms and their association with disease outcome 3. Bioautographic studies of anti-microbial extracts isolated from soil bacteria 4. Cloning genes for pharmaceutically important proteins 5 Isolation of medically important natural products from natural sources Publications: Books and Book Chapters Behravan, J., Piquette-Miller, M. (2006). Role of ABC drug efflux transporters in placenta. In: Edwin C. Hearns (Ed.), Trends in Biotechnology Research, Nova Publishers, NY, USA. pp. 251-266. Behravan, J. (2003). Molecular Biotechnology a practical approach (Persian Translation). Volume 1, Mashhad University of Medical Sciences Press. Mashhad. Iran. Selected Publications Jaafari, M. R., Behravan, J., Abde-Emami, J., Saghafi-Khadem, F., Ramezani, M. (2006). Evaluation of leishmaniciadal effects of Euphorbia bungei Boiss extract by in vitro leishmanicidal assay using promastigotes of Leishmania major. Int. J. Pharmacol Vol. 2 (5): 571-5. Behravan, J., Hemayatkar, M.,Toufani, H., Abdollahian, E. (2006). Lack of association of DRD2 gene TaqI polymorphism with schizophrenia in an Iranian population. Aust Nz J Psychiat. Vol 40. pp. A129. Mosaffa, F., Behravan, J., Karimi, G., Iranshahi, M. (2006). Antigenotoxic effects of Satureja hortensis L. on rat lymphocytes exposed to oxidative stress. Arch. Pharm. Res. 29 (2): 159-164. Gedeon, C., Behravan, J., Piquette-Miller, M., Koren, G. (2006). Transplacental transport of glyburide and its implications for treatment of gestational diabetes. Placenta 27(11-12):1096-102. Behravan, J., Naghibi, M., Mazloumi, M.A., Hassany, M. (2006). Polymorphism of angiotensin II receptor type 1 gene in essential hypertention in an Iranian population. Daru 14 (2): 82-86. Jaafari, M. R., Behravan, J., Bodaghabadi, A., Ramezani, M. (2006). Evaluation of leishmaniciadal effects of Euphorbia myrsinites extract by in vitro leishmanicidal assay using promastigotes of Leishmania major. Iranain J. Basic Med. Sci. Iranian J. Basic Med. Sci. (IJBMS) Vol. 8 (4).pp 295-8. Ramezani, M., Behravan, J., Yazdinezhad, A. (2006). Composition and antimicrobial activity of volatile oil of Artemisia koptdaghensis Krasch., M. Pop. & Linecz ex Poljak from Iran. Flavour and Fragrance Journal. Vol. 21 (6): 421-423. Behravan, J., Ramezani, M., Hassanzadeh, M. K., Eskandari, M., Kasaian, J., Sabeti, Z. (2006). Composition and antimicrobial activity of Ziziphora clinopodioides Lam. essential oil from Iran. Journal of Essential Oil Bearing plants. 9 (2): 196-203. Jami al Ahmadi, K., Tabatabaei Yazdi, M., Fathi Najafi, M., Faramarzi, M. A., Zarrini, G., Shahverdi, A., Behravan, J. (2006). Isolation and characterization of a chitionolytic enzyme producing microorganism, Bacillus chitinolyticus from Iranian ecosystem. Submitted. Behravan, J., Fazli Bazzaz, B.S., Malaekeh, P. (2005). Survey of Bacteriological contamination of cosmetic creams in Iran. Int. J. Dermatol. 44: 482-485. Hosseinzadeh, H., Behravan, J., Ramazani, M., Ajgan, Kh. (2005). Anti-tumor and cytotoxic evaluation of Crocus sarivus L. stigma and petal extracts using brine shrimp and potato disc assays. Journal of Medicinal Plants. Vol. 4 (15): 59-65. Hosseinzadeh, H., Behravan, J., Ramazani, M., Zargarnia, Z. (2005). Antitumor activity of adenosine and cyclohexyladenosine using potato disc assay. Iranain J. Basic Med. Sci. (IJBMS) Vol. 8 (1).pp. 13-17. Behravan, J., Ramezani, M., Hassanzadeh, M. K., Eliaspour, N., Sabeti, Z. (2005). Cytotoxic and antimycotic activities of Artemisia turanica Krasch from Iran (submitted). Behravan, J., Ahmadpour, H. (2004). Cloning and characterization of directly amplified antiviral gene interferon alpha-2b (HuIFN-2b) from human leukocytes chromosomal DNA. Arch. Pharm. Res. 27 (7):776-780. Behravan, J. Rangsaz, Z. (2004). Detection and characterization of -lactam resistance in Bacillus cereus. TheScientificWorldJOURNAL. 4:622-27. Behravan, J., Ramezani, M, Kasaian, J., Sabeti, Z. (2004). Antimycotic activity of the essential oil of Satureja mutica Fish & C. A. from Iran. Flavour and Fragrance Journal. 19 (5): 421-423. Ramezani, M., Behravan, J., Yazdinezhad, A. (2004). Chemical composition and antimicrobial activity of volatile oil of Artemisia khorasanica Podl. from Iran. Pharmaceutical Biology. 42 (8): 599-602. Behravan, J., Fazly Bazzaz, B. S., Salimi, Z. (2003). Optimization of dextran production by Leuconostoc mesentroides NRRL B-512 using cheap and local sources of carbohydrate and nitrogen. Biotechnol. Appl. Biochem. 38 (3): 267-269. Tavakoli Afshari, J., Zamani, A., Behravan, J., Shisheian, B. and Seifi, B. (2003). Semi-quantitative determination of Interferon gamma mRNA by RT-PCR. Scientific Journal of Hamadan University of Medical Sciences and Health Services. 28 (2): 5- 11. Moir, A., Corfe, B. M., and Behravan, J. (2002) Spore germination. Cell. Mol. Life Sci. Vol. 59 (3):403-409. Behravan, J., Ramazani, M., Malakzadeh, E. (2002). Evaluation of antitumor activity of two synthetic sulfonamides, XSF and SSF by a potato disc assay. Iranian J. Basic Med. Sci. (IJBMS) Vol. 5 (3): 135-9. Behravan, J., Ramazani, M., Heidari, A. (2002). Screening of organisms isolated from different places in Mashhad, Iran for antibiotic production by a cross-streak method. Iranain J. Basic Med. Sci. (IJBMS) Vol. 5 (1): 12-16. Behravan, J., Moir, A. (2002). Cloning of partially digested fragments of Bacillus cereus chromosomal DNA in bacteriophage lambda, construction of a ZAP DNA library. Iranain J. Basic Med. Sci. (IJBMS) Vol. 4 (4): 201-206. Tackray, P.D., Behravan, J., Southworth T. W. & Moir, A. (2001). GerN, an antiporter homologue important in germination of Bacillus cereus endospores. J. Bacteriol. Vol. 183 (2): 476-482. Behravan, J., Chirakkal, H., Masson, A. & Moir, A. (2000). Mutations in the gerP locus of Bacillus subtilis and Bacillus cereus affect access of germinants to their target in spores. J. Bacteriol. Vol. 182 (7). pp.1987-1994. Behravan, J., Moir, A. (2000). Identification, cloning and sequencing of the hexacistronic gerP operon from Bacillus cereus. Iranian J. Basic Med. Sci. (IJBMS)Vol. 2(3).pp.127-138. Behravan, J., Moir, A. (2000). PCR amplification, cloning and molecular characterization of a grmA homologues gene which has high homology to sodium- proton antiporter (napA) gene of Enterococcus hirea. Iranian J. Basic Med. Sci. (IJBMS).Vol. 3(1).pp 45-51. Fazly Bazaz, B.S., Behravan, J., Nabizade, M. (2000). Formation of Bacillus subtilis biofilm on pharmaceutical packaging surfaces. Iranian J. Basic Med. Sci. (IJBMS) Vol. 3(1).pp.20-26.