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									            Agilent in Traditional Chinese Medicine (TCM)

TCM Market Facts
  According to the Taiwanese Economics Department, 80% of the world population
  uses traditional medicine

   According to the State Drug Administration of China, the largest market for
   traditional Chinese medicine (TCM) export is Asia, accounting for 66.2% of the total
   market in 2002 with a value of US$444 million

   North America is the second largest with a value of US$100million followed by
   Western Europe and Africa with values of US$77.8 million and US$11.3 million

   Growth rates in for the TCM market in 2002 were 8% in Europe, 6% in the United
   States and 3% in Asia (the increase in relatively lower in Asia, as TCM has become
   an established alternative to Western medicine for many years)

   The World Federation of Chinese Medicine Societies (WFCMS) was founded in
   China to establish an international standard for TCM. All Chinese TCM clinics,
   practitioners and academic institutions must follow standards set by the WFCMS.

   The State Drug Administration (SDA) under the Ministry of Health (MOH) in China
   has laid down guidelines to ensure that manufacturers and herbal farmers are
   following Good Manufacturing Processes (GMP) and Good Agricultural Processes
   (GAP). The SDA has made further enforcement by requiring all manufacturers and
   farmers to comply with these standards by 2007 and 2004 respectively

   At the 2002 International Conference and Exhibition on Modernizing Traditional
   Chinese Medicine (ICETCM) Li Xueyong, deputy minister of science and technology,
   said China would depend on scientific progress to completely modernize and
   internationalize traditional Chinese medicine.

For more than 35 years, Agilent has addressed the needs of the entire pharmaceutical
value chain with solutions for drug analysis and development, quality assurance and
control, manufacturing and regulatory compliance. Agilent is now applying its analytical
expertise to the area of TCM testing.

June 2006                                                                        1
            Agilent in Traditional Chinese Medicine (TCM)

Like modern pharmaceuticals, herbal remedies used in TCM can have serious side
effects and interactions. Therefore comprehensive testing procedures for quality control
and assurance are important to their safe and effective use. Areas of testing include:

      Product quality – extract and analyse harmful components in TCM to prevent,
      for example, adulteration of other substances
      Pesticides/metals & inorganic substances – detect minimal/acceptable limits
      in TCM
      Regional variations – determine active components in TCM that are grown in
      different regions
      Active components – identify concentration of active ingredients with
      therapeutic qualities in TCM

As a world market leader in gas chromatography, liquid chromatography, mass
spectrometry, Agilent provides the key technology platforms used in TCM testing:

Gas Chromatography (GC)
Chromatography separates compounds into their individual components so that they
can be identified and quantified. Molecules must be in gas or vapor phase at 400-450°C
or below to be analyzed by gas chromatography (~10-20% of compounds)

Liquid Chromatography (LC)
Liquid chromatography is required to analyze most (80-90%) compounds, specifically
small organic molecules to higher molecular weight compounds such as proteins.

Mass Spectrometry (MS)
Mass spectrometry measures the molecular weight of a compound to determine its
identity and quantity in a mixture. Often used in combination with GC, LC or CE
(capillary electrophoresis). Sample goes through separation (by GC, LC or CE), then
MS (steps include ionization, mass sorting, ion detection), then data analysis.

Inductively Coupled Plasma- Mass Spectrometry (ICP-MS)
ICP-MS is form of mass spectrometry that uses a more powerful ionization source. This
technique is commonly used for element detection and trace analysis.

June 2006                                                                       2
            Agilent in Traditional Chinese Medicine (TCM)

Agilent Traditional Chinese Medicine Applications

Analysis of fangchinoline and tetrandine in traditional Chinese medicine by capillary

Quantitation of the alkaloids berberine, palmatine and jatrorrhizine in Mahonia stem by
capillary electrophoresis

 Analysis of chlorogenic acid in traditional Chinese medicines by capillary

Analysis of Mahuang Chinese Herbal Medicine by capillary electrophoresis

Extraction and HPLC Analysis of Alkaloids in Goldenseal

Using Lead Isotope Ratios to Distinguish between Samples of the Traditional Chinese
Medicine Dan-shen

About Agilent Life Sciences & Chemical Analysis

      Agilent Technologies Inc. (NYSE: A) is a global technology leader in
      communications, electronics and life sciences. The company’s 35,000
      employees serve customers in more than 110 countries. In 2002, Agilent had net
      revenue of $6 billion.

      Agilent’s Life Sciences and Chemical Analysis (LSCA) group is a world leading
      provider of instruments, supplies, software and services to life science and
      chemical analysis markets. In 2002, these markets accounted for approximately
      40% and 60% respectively of LSCA’s $1.1 billion in revenue. Agilent LSCA is a
      global organization with 3,700 employees, five international manufacturing sites
      and worldwide sales and support services.

June 2006                                                                         3

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