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					                                                                              Schering-Plough Corporation
                                                                              2000 Galloping Hill Road
                                                                              Kenilworth, NJ 07033 USA
                                                                              Phone +1 908 298 4000
                                                                              www.schering-plough.com




June 18, 2008

Dear Valued Customer,

We are pleased to announce that as of July 1st, 2008, Schering-Plough has partnered with Besse
Medical to provide TICE® BCG, BCG LIVE (for intravesical use), to direct ordering customers
through a new TICE® BCG Direct Program. In connection with the launch of this new program,
Schering-Plough will discontinue distribution of TICE® BCG to all direct ordering customers. It is
important to note that while Schering-Plough has partnered with Besse, our customers can
continue to order product from their current or other suppliers of TICE® BCG.

As a result of this discontinuation, it will not be possible for you to order TICE® BCG directly from
Schering-Plough after June 26, 2008. We therefore strongly encourage you to contact Besse
Medical or another supplier as soon as possible to ensure that you will be able to access TICE®
BCG after June 26 (setting up a an account with a distributor often takes about 3-4 business days).
You may want to consider ordering some additional product to carry you through this transition
period.

Besse Medical, part of the AmerisourceBergen Specialty Group, is a leading direct distributor in the
United States and therefore an ideal partner for the new TICE® BCG Direct Program. When
ordering TICE® BCG through the TICE® BCG Direct Program:

      You will now be able to order TICE® BCG until 7 pm EST (Monday-Thursday) for overnight
      delivery and Friday until 5 pm EST for delivery on Monday
      You can expect a state-of-the-art Web-based ordering system that allows you to place
      and manage orders, track shipments, make payments, and generate pedigrees
      You will be served by dedicated inside account representatives with overall responsibility for
      your satisfaction with Besse
      You can expect expedited account establishment for new Schering-Plough accounts

We have tried to structure the TICE® BCG Direct Program so that it will be as similar as
possible to the current direct purchasing program through Schering-Plough. Therefore, your pricing
for TICE® BCG will not change on July 1st and there will be no charge for overnight delivery.
However, Schering-Plough and Besse reserve the right to adjust pricing and other terms and
conditions of the Program from time to time.

The staff members at Besse are eager to make contact with you to better understand your specific
account needs and to ensure a smooth transition. Besse can be reached at 1-888-252-5585.

Schering-Plough continues to work at meeting the needs of our customers, and we are very
excited about the new TICE® BCG Direct Program. Thank you for being a valued customer.
Kindly call us at 1-800-222-7579 if you have any questions about our new relationship with Besse.
Please see accompanying full Prescribing Information.

Regards,

Jack Micali
Global Director, Marketing
Schering-Plough