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					    IN BRIEF

                                                          ‘Most Cited Article’ written by TNO
                                                          A journal publication attracts the attention of many researchers.

                                                          Maud Koek, Bas Muilwijk and Mariët van der Werf (TNO Quality of Life in Zeist) along with Thomas
                                                          Hankemeier (University of Leiden) last year published the article Microbial Metabolomics with Gas
                                                          Chromatography/Mass Spectrometry in Analytical Chemistry. This article has been nominated ‘Most
                                                          Cited Article’ by the publisher ACS Publications. In other words, it is among the journal’s most quoted
                                                          articles in that year – ‘research of immediate interest’ according to ACS Publications.
                                                             Metabolomics research focuses on identifying the changes in the metabolites (metabolism products)
                                                          in cells, cell tissue or bodily fluids, like blood, depending on changing environmental circumstances.
                                                          Separation and detection techniques are required to identify these metabolites and measure the huge
                                                          variety of compounds. Koek’s article describes a method of measuring the greatest number of
                                                          metabolites in the biological material (blood, cells, micro-organisms), which involves coupling gas
                                                          chromatography to mass spectrometry. The method can be applied to microbial (microorganisms),
                                                          mammalian (blood, urine, tissue) or plant metabolomics studies. For example, to identify bottlenecks in
                                                          microbial production processes or to look for metabolites in human blood that correlate to particular

    IGRAC becomes a 
    UNESCO institute 
    During UNESCO’s General Congress later this
                                                          New bio-aerosol 
    year, IGRAC will be formally declared a
    UNESCO institute.
                                                          test facility 
    The aim of the International Groundwater              TNO has recently started using a new
    Resources Assessment Centre, or IGRAC, is to          bio-aerosol test facility for its defence,
    gather information on the groundwater present         security and safety field of work.
    throughout the world and make this knowledge
    available, especially to developing countries. This   The new 12 m3 test facility gives a significant
    independent groundwater information centre,           boost to TNO’s research capabilities in the
    founded in part on the initiative of UNESCO, is       field of biological agent detection. While
    incorporated within TNO Built Environment and         current use focuses on testing and optimising
    Geosciences in Utrecht. The institute will gain the   bio-detection equipment in relation to product
    status of an UNESCO category 2 institute. This        development, other applications are equally
    category receives no funding from UNESCO.             feasible and include decontamination,
       The decision of principle was taken during the     deposition and agent fate.
    meeting of UNESCO’s Executive Board earlier this         Stable and reproducible aerosol
    year when various countries from the United           concentrations can be generated in the
    States, China, Yemen and Indonesia to                 aerosol chamber. The air flow speed
    Afghanistan, Uganda and Egypt heaped praise on        (maximum of 11750 litres per minute),
    the Dutch activities in the area of water.            humidity and temperature can all be
                                                          regulated. Various non-pathogenic bacteria,
                                                          viruses and toxins can be aerosolised. The
    Info:,              facility also has several connection options for
                                                          the equipment being tested.

                                                          (business developer),
                                                 (market manager)

    TNO magazine  September 2007

project: ‘Hygiene 
for Health’                                                                                                                    A Coarse Sun Sensor (CSS).

How can hospital instruments be better
cleaned and sterilised?
                                                      Sensors for Galileo
Increasingly more exploratory operations are          TNO has delivered an initial series of solar sensors for the Galileo project.
taking place in hospitals – also for taking samples
for minor surgical treatment. The endoscopes and      At the end of July the ASTRIUM space company in Munich took delivery from TNO and Bradford
other instruments used are becoming more and          Engineering (BE) of eight flight models of Coarse Sun Sensors (CSS) that will be built in to the first four
more complex, making proper cleaning and              navigation satellites of the Galileo project. Soon to follow are eight Fine Sun Sensors (FSS) that are
sterilisation of them more difficult.                 being developed by TNO and made by BE. Galileo is the European system for satellite navigation, a
   In order to improve the hygiene in the clinics     counterpart to the American GPS satellites. The delivery programme for the first four satellites is called
and thus safety of patients, the Hochschule           Galileo IOV, the In Orbit Verification phase. Ultimately, the Galileo constellation will comprise thirty
Niederrhein in Krefeld, together with partners on     satellites.
both sides of the German-Dutch border, has               A CSS is a flat aluminium structure, painted black, with a truncated pyramid at its centre. On the four
started the research and development project          sides of the pyramid silicon photodetectors resembling solar cells look out in four directions. The field of
‘New Business Opportunities in Hygiene for            view of the four detectors covers half a sphere; two sensors cover the entire sky. The satellites status
Health’. This project, lasting two years and with a   controller can derive from the CSS signals where the sun should be in the sensor field of view, to an
budget of 1.7 million euros, is being backed by       accuracy of about two degrees. TNO has been making solar sensors like this since 1974. They have
the European Union through the Interreg IIIA          already earned their spurs in various space missions, with tens of satellites currently equipped with
Programme. The Dutch Ministry of Economic             these status sensors.
Affairs, the provincial authorities of Limburg and       Bradford Engineering was commissioned by TNO to make the hardware and carry out most of the
the local German authorities are also lending         acceptance tests, partly in preparation for the series production of sensors for the other 26 Galileo
their support.                                        satellites. The role of TNO, as the acknowledged European specialist in solar sensors, is chief supplier of
   The project is investigating how the quality and   sensors to ASTRIUM. TNO has also been responsible for the design and engineering of both types of
safety of the respective medical instruments can      sensor and for the specification and acquisition of several highly specific components.
be guaranteed or even improved. Research
focuses on cleaning, disinfecting and sterilising     Info:
the instruments and hard surfaces. Eventually the
cleaning of instruments will increasingly be
outsourced by hospitals and medical practices to

                                                      Cross-border Geological Atlas 
external service providers.
   Other participants in the project are the wfk-
Forschungsinstitut für Reinigungstechnologie in
Krefeld, the Institut für Umwelt- und                 in progress
Energietechnik (IUTA) of the University of
Duisburg-Essen, TNO and hospitals and                 A Geological Atlas will be mapping the Southern Permian Basin Area from Great Britain to
companies in the Rhine-Maas-North region. TNO         Poland.
will be contributing specifically to the
development of bacteria-repelling surfaces and        Together with the national geological surveys of Great Britain, Belgium, Germany, Denmark and Poland,
plasma technology for cleaning instruments.           companies active in oil exploration and production, consultants, research institutions and universities,
Workshops will also be organised for companies        TNO is working on a Petroleum Geological Atlas. This will map the Southern Permian Basin Area (SPBA)
from the region.                                      and thus provide an extensive, systematic overview of more than 150 years of research into geological
                                                      basins in the deep subsurface that are of special interest in respect of oil and gas exploration. The Atlas
Info:,                       will provide a valuable source of information for governments, researchers and, naturally, the oil and gas                                industry. The SPBA Atlas will be available in two versions: on paper (A2 format) and as a pdf file. The
                                                      maps in this Atlas will be mainly on a print scale of 1:3,000,000 and will be also made available as a
                                                      GIS product. The date for completion of the SPBA Atlas is 2009.


                                                                                                                                       September 2007 TNO magazine 

     The Hague as 
     ‘Secure Haven’ 
     The Hague Campus (University of Leiden),
     Capgemini and TNO are starting the
     ‘Secure Haven’ study in The Hague.

     A combination of safety and comfort for a
     pleasant and secure living and working
     environment – that’s the aim of ‘Secure Haven’.
     The concept represents an entirely new approach
     to security from the perspective of comfort.
     Structure, protection and security of the
     infrastructure and residential surroundings are
     central. ‘Secure Haven’ links innovation to
     infrastructure, where high-tech, not immediately
     apparent technology boosts security and creates
     a pleasant and comfortable living and working
     environment. And those factors will give a boost
     to the economy.
        The Hague wants this concept to create a
     favourable and sustainable location for
     international organisations and companies in
     order to strengthen the local economy. The
     Hague is known as the world’s legal capital for

                                                         Route information system for Drymer 
     international justice and peace, where not only
     various UN and international offices are located
     but also embassies and the headquarters of
     many multinationals. It all makes The Hague         TNO has developed a tourist route information system for an innovative vehicle, the Drymer.
     perfectly suited to develop the ‘Secure Haven’
     concept.                                            It’s a three-wheeler with a very special tourist route information system. The Drymer is a new, futuristic
        The initiators want to develop a blueprint and   and innovative three-wheeled covered vehicle presented for the first time in July this year. The original
     policy innovation to enable the residence to        TNO idea was made ready for production by TCNN (Technology Centre North Netherlands) in
     gradually become a ‘Secure Haven’. The Hague        collaboration with companies and professional universities in the north of the country as well as the
     pilot will last two years and has a budget of 4.5   University of Groningen and TNO.
     million euros.                                          The tourist information system developed by TNO for the Drymer was based on the TomTom, the most
                                                         popular Dutch plug-in navigator. A route was set out via Google Earth and text and photos added at key
     Info: (projectleader),          points along the route using an application developed by TNO. A software package developed by TNO (marketing manager)                and ICT Ten Hove enables the route to be loaded on a TomTom Rider directly or via internet. The user
                                                         then navigates along a specially designed tourist route, also outside of the normal TomTom routes if
                                                         wished. Whenever the user approaches a pre-defined point of interest (like a church, monument or
                                                         restaurant), he or she is notified by the TomTom Rider; the user can then opt to look up more
                                                         information about that point.
                                                             The system should appeal to tourist information offices, walking, cycling and motorcycle clubs,
                                                         archaeological associations, large tourist accommodation centres, centres for nature education and the
                                                         like. ICT Ten Hove will be commercialising the system.


     TNO magazine  September 2007
                                                                                 Photo: OGC

ConSoil 2008 in Milan                                                                                       From ‘Traffic and 
The next ConSoil conference, from 3 to 6 June 2008 in Milan.
                                                                                                            Transport’ to 
The tenth in a series of successful conferences on soil and groundwater contamination and
decontamination, begun on the initiative of TNO in 1985, will be held at the Stella Polare conference
centre in Milan. Its central theme will be the performance of soil-water systems. This conference thus      New name is better reflection of policy
remains the number one European platform in this field for the exchange of knowledge and                    themes.
experience among scientists, researchers, policymakers, engineering firms, decontamination
companies, soil managers and other relevant parties. The conference is being organised by the               TNO has decided to change Traffic and Transport
Helmholtz-Zentrum für Umweltforschung UFZ, the provincial authority of Milan and TNO.                       into Mobility to better reflect its focus on the
                                                                                                            policy themes of government and industry.
Info:;                                                                  Mobility in a social context where liveability and
                                                                                                            space are key components. And it’s a name that
                                                                                                            will help support and strengthen TNO’s market
                                                                                                            profile and positioning.

ICT Space Team                                                                                                 This market, which is undergoing significant
                                                                                                            growth, is served by some four hundred TNO
                                                                                                            experts around the world. It is the field that
A new star in space.                                                                                        combines their expertise of vehicle technology
                                                                                                            and engineering, ICT, driver behaviour and traffic
Various TNO units have been active in space exploration for years, but for TNO Information and              systems. A field in which passive and active
Communication Technology this is a relatively new field.                                                    safety are integrated through the use of in-
   A special ICT Space Team has been formed to closely track developments in the field of satellites and    vehicle intelligence and infrastructure planning
explore any market opportunities that could derive. The interest focuses on developments in                 and management as well as innovative concepts
telecommunication per satellite as well as for developments concerning Galileo, the European                for logistics are developed.
counterpart of the American GPS satellites. The European system for satellite navigation is                             
predominantly being developed by the larger EU member states such as Germany, Italy and France,             Info:
though Galileo is also important for Dutch companies.
   Developments in telecommunication that had been primarily the domain of the regular telecom
operators will also be playing an increasingly significant role in the space exploration segment; for
instance, All-IP IMS (IP Multimedia Subsystems) and integrated service concepts. As for Galileo, the
emphasis is on the development of services once Galileo becomes operational. TNO is participating this      TNO office in 
year in the European Galileo Competition, whose challenge is to come up with the most original service
that will demonstrate Galileo’s added value in the future.
   TNO is also involved in two actual Galileo projects – MAGES (that is investigating the operational
model behind one of the Galileo services) and Pacific (concerning standardisation) – and is participating   TNO’s Brussels office looks back on a
in various tenders.                                                                                         successful first year.

Info:                                                                                 As with some of the other large Research and
                                                                                                            Technology Organisations (RTOs), TNO also has
                                                                                                            an office in Brussels. Right in the middle of the
                                                                                                            European district, the office opened a year ago. It
                                                                                                            plays a key role in representing TNO towards the
                                                                                                            European institutions, fellow RTOs in other
                                                                                                            European countries, NATO and various European
                                                                                                            organisations. The office in Brussels is intended
                                                                                                            to boost the visibility of TNO towards European
                                                                                                            policymakers and administrators as well as
                                                                                                            strengthen the collaboration with other parties,
                                                                                                            within the Seventh Framework Programme for
                                                                                                            example. At the same time, the Brussels Office
                                                                                                            also functions as TNO’s first point of contact in

                                                                                                                                    September 2007 TNO magazine 

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