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					     Medical Physics
     Group
     Newsletter




     No. 28            Oct – Dec. 2006
Institute of Physics
Medical Physics Group Committee
Dr A Gibson           Department of Medical Physics and Bioengineering,
Chairman              University College London, WC1E 6BT.
                      Tel: 020 7679 0279
                      E-mail: agibson@medphys.ucl.ac.uk
Miss R Quest          Charing Cross Hospital, London.
Hon Secretary         Tel: 020 8383 0642
                      E-mail: r.quest@imperial.ac.uk
Dr C Baker            University of Liverpool, Liverpool.
Hon Treasurer         Tel: 0151 794 5754
                      E-mail: colin.baker@liverpool.ac.uk
Dr K Wells            University of Surrey, Guildford.
Meetings Secretary    Tel: 0148 368 6036
                      E-mail: k.wells@surrey.ac.uk
Dr P Campbell         Ninewells Hospital, Dundee, DD1 9SY.
                      Tel: 01382 496490
                      E-mail: p.a.campbell@dundee.ac.uk
Dr R Dickinson        Imperial College, London.
                      Tel: 020 7584 6897
                      E-mail: robert.dickinson@imperial.ac.uk
Dr K Isaak            Cardiff University, Cardiff, CF24 3YB.
                      Tel: 029 2087 0156
                      E-mail: kate.isaak@astro.cf.ac.uk

IPEM Nominated Members
Dr S Keevil           Kings College London, London, SE1 9RT.
                      Tel: 020 7188 3054
                      E-mail: stephen.keevil@kcl.ac.uk
Miss S Misson         Southampton University Hospitals, Southampton, SO16 6YD.
                      E-mail: sarah.misson@suht.swest.nhs.uk
Prof. P Sharp         University of Aberdeen & Grampian Hospitals, Aberdeen, AB25 2ZD.
                      Tel: 01224 552499
                      E-mail: p.sharp@biomed.abdn.ac.uk

Co-opted Members
Prof. J W Hand       Hammersmith Hospital, London.
                     Tel: 020 8383 3983
                     E-mail: j.hand@imperial.ac.uk
Dr J G Truscott      Leeds General Infirmary, Leeds.
                     Tel: 0113 392 3489
                     E-mail: j.g.truscott@leeds.ac.uk




                                            2
        The Institute of Physics Medical Physics Group
The Medical Physics Group (MPG) was formed in 1996 following consultations
between the Institute of Physics (IoP) and the Institution of Physics and
Engineering in Medicine (IPEM).
The MPG has a membership of over 600 and its remit is to;

    encourage physicists whose areas of work appear to have medical
     potential
    collaborate with clinical physicists and engineers in order to benefit from
     their experience of clinical problems
    identify and progress areas of training and education, related to medical
     physics that will benefit from such collaboration.

Services provided by MPG include both organisation and co-sponsorship of
scientific meetings, an informative website, an annual essay competition, and
publication of a Newsletter. MPG also represents IoP within the Association of
Institutions concerned with Medical Engineering (AIME) and on the executive
of the Royal Academy of Engineering‟s UK Focus for Biomedical Engineering.

Medical Physics is a long established specialty, but not all medical applications
of physics originate within the scope of clinical medical physics. There has been
a history of crossover from other areas of physics that has contributed greatly to
the growth of the field.

One of the aims of the group is to encourage such interactions between IPEM
and the wider areas of physics encompassed by IoP. Another significant
advantage of collaboration is in the field of education where IoP and IPEM have
complimentary accreditation activities in first degrees and medical physics
higher degrees/professional training respectively.

The medical applications of physics are of interest to a broad spectrum of IoP
members. Linking science with social relevance and providing opportunities for
technology transfer leading to real products and markets.

The constitution of the MPG differs from other IoP groups in that all IPEM
members are able to participate in Group activities. The IPEM nominate three
members to serve on the MPG Committee in addition to those elected to serve
by IoP members.

If you are interested in joining the MPG and supporting its activities please
contact membership@iop.org




                                        3
Medical Physics Group Newsletter
The Newsletter aims to provide a forum for the exchange of information and
ideas between those active in the field of medical physics and those who have an
active interest in the subject.

The cover image used for this newsletter is of PET/CT scan.


Medical Physics Group Website
The Group‟s website offers a bright new gateway to the world of Medical
Physics. The website aims to give up-to-date information about the Medical
Physics Group and its activities together with more general information about
the world of medical physics.

The pages for the Group have been transferred to the new Institute of Physics
website at:

http://www.iop.org/Our_Activities/Groups_and_Divisions
          /Subject_Groups/Medical_Physics/page_2075.html



Publication of all material within this Newsletter is subject to the following
disclaimer: Articles published within the Newsletter or posted on the Group's
website are not peer reviewed. They express the author's point of view but
publication does not imply acceptance or endorsement of the ideas expressed by
the Institute of Physics' Medical Physics Group, by the Group's management
committee or membership, nor by the Institute of Physics, nor any of its
employees or officers.




                                       4
Meeting Reports

    International Society for Magnetic Resonance in Medicine,
                 14th Scientific Meeting and Exhibition,
                       May 6-12 2006, Seattle, USA

The International Society for Magnetic Resonance in Medicine (ISMRM) holds
the leading meeting for those involved in magnetic resonance imaging (MRI)
every year, in addition to more specialised meetings and workshops across the
world. The intimidating thing about the conference is its size, with over 3500
abstracts, and the feeling that there is too much to see and you can never do it all
or even enough. All you can do is focus on what you‟re doing and pick and
choose the sessions that you go to, even looking out for the particular topic or
presenter. That‟s why the most useful piece of the welcome pack is the planner
to sort out what you‟re going to see when. There are multitudes of different
topics and within each of those there are the technical sessions of scientific
interest, the clinical sessions where the practical implementation is presented,
the never ending poster sessions and the more informal debates and discussions
which can take place in the educational and study group sessions outside the
main meetings.

The conference was as always opened with the Mansfield Lecture, which this
year took on a slightly different direction in MRI from a very American
perspective. Elias Zerhouni, of the National Institute of Health (NIH) at
Bethesda USA, talked about the role of imaging in 21 st century healthcare.
Obviously there is was a lot of discussion about the cost effectiveness of
healthcare which, while relevant in the context of whether or not the National
Institute of Clinical Excellence will eventually fund the treatment, was not an
immediate concern of most UK researchers. It may become more relevant as
funding changes, but maybe never to the extent in the US with widespread
private heath insurance and the availability of MRI scans in most malls!

Following the preliminaries it was time to follow my own advice and focus on
my area of probabilistic tractography,
particularly as I was presenting later in the “Probabilistic tractography
conference. Probabilistic tractography uses uses diffusion weighted MRI
diffusion weighted MRI images to determine         images to determine the
the propagation of free water which is            propagation of free water
restricted, in the brain, by the direction of     which is restricted, in the
white matter fibre bundles. The modelling of      brain, by the direction of
this allows for the determination of the white matter fibre bundles.”
Probability Density Function of possible fibre
directions at a voxel level and a Monte Carlo technique is used to assess the

                                         5
likelihood of a fibre tract being present. In the MRI community this isn‟t a large
grouping, but one in which the UK is very well represented both in terms of the
abstracts presented and the committee of the Diffusion and Perfusion Study
Group. The study groups are an important part of the society to ensure that the
exchange of views and critical mass of researchers are not confined to a single
week once a year. The meeting focused on a debate on the controversies present
in this area with a discussion of whether “Diffusion MR can measure anything”.
This was an excellent discussion of the limitations which apply to all the
conclusions from tractography and the importance as scientists to always
remember this when discussing it with our collaborators. The group also set out
its plans to organise a multi day conference specifically for the discussion of
diffusion and the current progress towards the important unanswered questions
in the field that the group as a whole has identified as the important areas of
research.

I was presenting in the session titled Tracts, Maps and Atlases and presenting
first! Despite my obvious nerves and the lack of opportunity to get into the
swing of things, it did give me the opportunity to listen closely to other very
relevant presentations. My presentation (David Morris, Manchester University
UK) detailed an initial attempt to try and attach a level of significance to the
                                         results obtained from probabilistic
       “I talked about the null          tractography. Previously there has been a
   distribution and how this could range of probability values given to every
         be compared with the            connection without any reasonable way
        experimental results to          of determining a threshold to indicate
    determine those connections          which connections were likely to be
  that were significantly different” present. This was further compounded by
                                         the distance effect which meant that
connections at different distances from the streamline start points could not be
directly compared. I talked about the null distribution and how this could be
compared with the experimental results to determine those connections that were
significantly different to the null, allowing for the setting of meaningful
thresholds based on statistical significance. Other papers showed the breadth of
research currently being undertaken in the field. Derek Jones (Cardiff
University, UK) gave a valuable paper discussing the use of Wild Bootstrapping
to estimate the uncertainty in fibre directions. This
                                                          “Wild Bootstrapping
has certain advantages over other methods, being
                                                          techniques where, the
model independent and not requiring any
                                                             available data is
calibrations based on the signal to noise ratio of the
                                                           shuffled to produce
diffusion weighted acquisition. However, a severe
                                                           additional data sets”
restriction is the requirement for the collection of
additional data, by a factor of 10, which makes it unsuitable for clinical use. It
was demonstrated that the use of Wild Bootstrapping techniques where, the
available data is shuffled to produce additional data sets, gave very similar
results to an extended data set, and demonstrated the clinical applicability of a
technique which could be developed for use with probabilistic tractography. An

                                        6
alternative analysis of this sort of data was presented by Steve Smith (Oxford
University, UK) who showed the addition of tract based spatial statistics (TBSS)
to the FMRIB groups‟ software library (FSL) to allow for the group wise
analysis of multi subject diffusion experiments. Previously, differences observed
between subjects with voxel wise analysis may have simply been down to a
failure to correctly register different anatomical images rather than any real
change in the diffusion parameters. The software defines a mean skeleton of the
principal tracts within the group, and then projects the diffusion variable of
interest from the closest structure in each individual scan on to the skeleton to
generate a register imaged for each subject that can compensate for
physiological differences. This has been used to identify areas where the
diffusion parameters have changed in patients with schizophrenia and motor
neuron disease.

Poster sessions are an important way to get a level of interaction that isn‟t
possible in the sessions. It‟s always helpful to be able to talk directly with others
in the field and discuss the nuances of a technique that haven‟t made it into the
final draft of their paper. Phil Cook et al from UCL (University College,
London, UK) described Camino which is an open source package allowing for
the complete analysis of diffusion images from simple voxel based statistics
through tensor directions to probabilistic tractography. This is an important step
in expanding the use of these techniques outside a few specialised institutions,
particularly considering the increasing availability with which these scans can be
obtained on commercial scanners.        Mariana Lazar and Andrew Alexander
from the University of Wisconsin (USA) had a poster describing the comparison
of two different probabilistic tractography methods based on parametric and non
parametric perturbations on the vector directions. This demonstrated that,
depending on the branching nature of the tract under investigation and the signal
to noise ratio available in the images, different fibre distributions may be
observed. This can give an important insight into the suitability of different
techniques, and may eventually allow for a measured comparison of different
techniques to determine the relative merits of each. A consensus on the best
techniques is required before the more general application of probabilistic
tractography, where at the moment each group tends to use their own favourite
variant.

The conference ends as always with the closing reception which was organised
at the Experience Music Project and Science Fiction Museum based at the Space
Needle. A master stroke of playing to an audience of scientists I feel! So at the
end you‟re left with a feeling of unbridled optimism of what is possible that will
carry you through the next year. As ever, quite a few people took advantage of
the location to spend some time travelling round what really is a quite unique
part of America. One advantage was that the timing allowed people to miss the
crowds after Memorial Day and gave some real seclusion in the national parks
surrounding Mount Rainier and Mount St Helens, which was apparently
bubbling away.

                                         7
I‟d nearly forgotten all about the conference until I was travelling back to the
airport and suddenly saw one of the conference bags being used by one of the
local down and outs as a pillow while he slept on the park bench. After all the
benefits of the meeting I just wondered if I really needed another conference
bag?

                                                                   David Morris
                          Imaging Science and Biomedical Engineering (ISBE),
                                   University of Manchester, Stopford Building,
                                                     Manchester, M13 9PT, UK



     The 18th International Conference on Pattern Recognition
                  Hong Kong, 20-24 August 2006.

The 18th International Conference on Pattern Recognition (ICPR 2006) was held
in Hong Kong Convention and Exhibition Centre (HKCEC) on 20-24 August
2006. This conference is the main event of the International Association for
Pattern Recognition (IAPR) held biennially in different parts of the world. It
offers a great opportunity to hear about and to discuss the latest results in the
extremely fast developing field of pattern recognition. A record-breaking
number of full paper submissions was received, 2029 papers from 48 countries.
A total of 311 papers were selected for oral presentation while 857 were selected
for poster presentation.

The first day of the conference was dedicated to tutorial sessions, in particular
biometric recognition, stochastic discrimination and ensemble learning, human-
centered vision systems, face-based biometrics, learning Bayesian networks,
content-based image and video retrieval and evolutionary algorithms for pattern
recognition.

The main conference itself opened on 21st August with the plenary speech given
by Professor Josef Kittler (University of Surrey) with the title „On context,
modeling, dimensionality and small size in pattern recognition‟. Apart from
Professor Kittler‟s talk, there were three additional plenary speeches starting
each morning of the remaining days. They were „Fingerprints: proving ground
for pattern recognition‟ by Anil K. Jain (Michigan State University); „Chinese
character recognition: status and process in research and applications‟ by Ru-
Wei Dai (Chinese Academy of Sciences); „What are classifier ensembles good
for anyway and how would you know?‟ by Lawrence O. Hall (University of
South Florida).


                                       8
The conference was composed of five tracks: Computer Vision and Image
Analysis; Pattern Recognition and Basic Technologies; Signal, Speech and
Image Processing; Systems, Robotics and Applications (with Associated Theme:
Biometrics); Cognitive Approaches & Soft Computing. My paper was in the
Cognitive Approaches & Soft Computing track.

I gave my oral presentation, which was entitled „Semantic Analysis on Medical
Images: A Case Study‟, in the afternoon of 21st August. The talk was allocated
in the „Semantic Analysis for Content Retrieval‟ session and everything went
very well. In the paper, semantic image analysis through an ontology case study
was investigated and provided a clear evaluation based on strings and
description logic (DL). This process is similar to       “semantic image
that used by humans and targets the lack of            analysis through an
semantics in Computer Aided Diagnosis (CAD)             ontology case study
systems. A clear understanding of semantic               was investigated”
medical image analysis was provided with which
CAD systems are expected to improve their performance. After my talk, I
received several related questions and comments from the audience. After the
session more in depth discussion followed and new contacts were made.

There were medical image processing session and biomedical imaging session in
the conference. The paper „A Framework for Automatic Segmentation of Lung
Nodules from Low Dose Chest CT Scans‟ by Ayman El-Baz et.al proposed an
approach to accurately separate each pulmonary nodule from its background in a
low dose computer tomography (LDCT) chest image. Two new adaptive
probability models of the visual appearance of small 2D and large 3D
                               pulmonary nodules are jointly used to control the
        “an approach to        evolution of the deformable model. Experiments
     accurately separate       with real LDCT chest images confirm the high
   each pulmonary nodule accuracy of the proposed approach. In another
   from its background in paper entitled „Bayesian MS Lesion Classification
     a low dose computer       Modeling     Regional    and    Local     Spatial
    tomography (LDCT)          Information‟, Rola Harmouche et.al. presented a
         chest image”          fully automatic Bayesian framework for multiple
                               sclerosis (MS) lesion classification, using
posterior probability distributions and entropy values to classify normal and
lesion tissue. The method was tested on 10 patients with MS by comparing
automatically classified lesions, with and without regional information, to
manual classifications by five expert raters using volume count and overlap.
Results improve with the incorporation of spatial information, and are
comparable to manual classifications.

Overall, this is the biggest conference in which I have so far participated. The
conference was very satisfying, well organized and of a high quality. It was a
great opportunity for communicating with leading people and learning the latest


                                       9
development in the field of pattern recognition. It was also a valuable experience
for my PhD study.

I would like to express my appreciation to the British Machine Vision
Association, the Medical Physics Group of the Institute of Physics and my
department for supporting me to attend ICPR 2006 in Hong Kong. It was worth
having this experience and opportunity of presenting my PhD work at such an
international conference.




At the banquet held
in the Grand Hall,
  the Hong Kong
  Convention and
 Exhibition Centre




                                                                      DA QI
                                            Department of Computer Science
                                                        University of Wales,
                                                   Aberystwyth, SY23 3DB.




       Report on IEEE International Ultrasonics Symposium
            Vancouver, Canada, October 3rd - 6th 2006

The IEEE Ultrasonics symposium is an annual event which this year was
attended by more than 1000 delegates from more than 46 countries making it
truly an international conference. There were over 700 papers presented
covering five main subject groups: medical ultrasonics, sensors, NDE and
industrial applications, physical acoustics, surface acoustic waves, and
transducers and transducer materials with 6 parallel oral sessions. The majority
of the sessions were on medical ultrasonics; within this group were sessions on
medical imaging, ultrasound contrast agents, signal processing, therapeutics,
cardiac imaging and blood flow amongst others.

                                       10
In the plenary session the speaker Kenneth Balcomb (Centre for Whale
Research, Washington) told about his work on the study of whales and told of
his personal experience of a mass beaching of beaked whales in the Bahamas in
2000. He found that this occurred following a U.S. Navy sonar exercise and was
able to collect many samples to investigate potential causes for the beaching.

Immediately after the plenary session was my poster session, Contrast agents:
watching and listening. My poster described an experimental technique I have
been developing for investigating individual ultrasound contrast agent attached
to surfaces. One application of ultrasound contrast agents, which are
microbubbles about 3 μm in diameter, is targeted drug delivery. The
microbubbles can be modified to contain a
drug and the shell adapted to target and bind to    “My poster described an
certain areas within the body. Ultrasound can       experimental technique I
then be used to disrupt the bubble shell,           have been developing for
delivering the drug directly to the site of          investigating individual
interest. In order to develop targeted ultrasound contrast agent
applications to their full potential the              attached to surfaces.”
interaction between attached microbubbles and
ultrasound needs to be more fully understood, I intend to study the acoustic
behaviour of contrast agents attached to a surface. My poster was well attended
during the 1 1/2 hour poster session. It was good to be able to talk to so many
people and even get some ideas about how to progress. It was also encouraging
to receive positive feedback about my work.

There was a large selection of talks on contrast agents and microbubbles making
the conference especially relevant. The first contrast agent oral session featured
an invited talk from Flordeliza Villanueva (University of Pittsburgh) and titled
Development of targeted ultrasound contrast agents. This talk was a great
overview of targeted contrast agents and their application to molecular imaging.
Targeted contrast agents have applications for enabling the detection of areas of
angiogenesis and inflammation amongst others. Other talks related to ultrasound
contrast agents described developments in targeted ultrasound imaging, and
developments in methods of imaging contrast agents using coded excitation
techniques.

As well as talks on ultrasound contrast agents I had the opportunity to attend
talks on tissue characterisation, blood flow, cardiac imaging and high frequency
imaging. Piero Tortoli (University of Firenze, Italy) presented an invited talk on
dual beam Doppler ultrasound developed to accurately measure the Doppler
angle for blood flow measurements. The standard approach of manually using
an angle curser to measure the angle of the vessel wall is inaccurate when the
blood flow is not parallel to the wall. The dual beam system allows the flow
direction to be determined using a reference ultrasound beam and the velocity
magnitude to be determined using a second beam. It was also very interesting to

                                       11
see a talk by Ernest Madsen (University of Wisconsin-Madison) on tissue
mimicking materials for intravascular ultrasound phantoms. Materials have been
developed, for use with intravascular ultrasound, which mimic tissue for
different plaque types and arterial wall.

The IEEE Ultrasonics symposium publishes short papers from each poster and
oral presentation presented at the symposium, I look forward to receiving my
copy when I will be able to read papers on talks I went to and also on talks I
didn‟t get the chance to attend. I‟d like to thank the Medical Physics Group for
the support for travel to this conference; I found it very enjoyable and
worthwhile and have returned with new ideas and new contacts.

                      Mairead Butler, Medical Physics, University of Edinburgh
                                                      email:M.Butler@ed.ac.uk



                             AIME
     Association of Institutions Concerned with Medical
                         Engineering
Medical engineering and technology is a major growth area in the UK's health
care market. Recent discussion between various institutions (professional
bodies) which have an interest in medical engineering has led to a consensus
opinion that, in order to be seen as a focused community, medical engineering as
a profession needs to be co-ordinated across its many disciplines.
Thus, in October 1998, AIME was born. A Memorandum of Understanding was
signed between the six member bodies, and work is now underway to
consolidate that understanding and move towards a combined voice for medical
engineering as a profession.

The constituent members of AIME are:
   The Institution of Chemical Engineers (IChemE)
   The Institution of Electrical Engineers (IEE)
   The Institute of Healthcare Engineering and Estate Management (IHEEM)
   The Institution of Incorporated Engineers (IIE)
   The Institute of Materials (IoM)
   The Institute of Physics (IoP)
   The Institution of Mechanical Engineers (IMechE)
   The Institution of Physics and Engineering in Medicine (IPEM)

For more information please visit the website: www.aime.org.uk



                                      12
       Financial Support towards the cost of attending
                    Overseas Meetings

The Medical Physics Group (MPG) within the Institute of Physics (IoP) is
pleased to announce that it is able to consider requests for partial financial
support towards the cost of attending overseas meetings. The purpose of the
scheme is to provide assistance to those working in areas of physics with
medical applications.

To be eligible applicants must;

    be no more than 35 years old,
    provide evidence of acceptance of a presentation (oral or poster) at the
     meeting in question. The meeting will normally be of sufficient scientific
     value that it is associated with continuing professional development (or
     similar) accreditation,
    provide evidence of Departmental or other financial support towards the
     cost of attending the meeting,
    provide a letter of support from their Department,
    provide a statement that no concurrent application for support is being
     made to the CR Barber Trust.

The maximum support available to any applicant will be £250.

In general the MPG Committee is able to provide a rapid decision regarding the
outcome of applications. The MPG Committee's decision regarding financial
support and its level will be final and non-negotiable in all cases.

Successful applicants will be asked to provide a short written report of the
meeting suitable for publication in the MPG's Newsletter.

To apply, please send letters from you and from your department, addressing the
points above, together with evidence that your presentation has been accepted,
to Dr C Baker at the following address:

Dr C Baker
Honorary Treasurer MPG
Division of Medical Imaging & Radiotherapy
School of Health Sciences
University of Liverpool
Brownlow Hill
Liverpool L69 3GB

Tel: 0151 794 5754       E-mail: colin.baker@liverpool.ac.uk


                                      13
Prize Soduku Solution

                  5    7    2    9    3    1    6    4    8
                  4    3    8    6    7    2    9    1    5
                  9    1    6    4    8    5    2    3    7
                  3    8    5    7    4    6    1    2    9
                  7    2    4    1    9    3    5    8    6
                  1    6    9    2    5    8    4    7    3
                  8    9    3    5    1    4    7    6    2
                  2    5    1    3    6    7    8    9    4
                  6    4    7    8    2    9    3    5    1


As you can see the numbers missing from the shaded cells were 9,5,5,1.

The first correct solution out of the “hat” was that sent in by Colin Orton who
receives a book token for £20 (or equivalent) and wildly ecstatic approbation
from the assembled multitude.




                                      14
Meeting Previews

   Human Shape: How can measurements and modelling
improve outcomes for patients with profound abnormalities of
                         posture?

                   25th January 2007, NCEM, York.

People with profound physical deformity require specialist interventions to
accommodate or correct shape. The aetiological reason for deformity may be
congenital or acquired; the deformity may be purely skeletal or have an
underlying neurological driver. Shape correction may include orthotic
appliances, adaptive seating and positioning, drug treatments or surgical
interventions to remediate a gross orthopaedic abnormality. The purpose of this
meeting is to explore the technology and methods currently available to measure
human shape and the procedures used to quantify the outcome of any
investigation.

What are the technologies available to quantify human shape? How practical are
they to use in the clinical setting and what caveats exist? Can independent
scientific measurement assist in providing or evaluating better shape correction
technologies?

Proffered papers are invited from interested healthcare professionals such as
orthotists, clinical scientists, rehabilitation engineering practitioners therapists
and medical practitioners, and from non-healthcare colleagues interested in
human performance and measurement.

Please send abstracts to both organizers below by 20 th October 2006. Electronic
submissions in MS Word format are preferred.

Dr Robert Farley                              Dr Adam Shortland
Clinical Bioengineer – Special                Consultant Clinical Scientist
      Needs Design                            One-Small-Step Gait and
Rehabilitation Engineering Services                 Movement Analysis Lab.
Eastern General Hospital                      Guy‟s Hospital
Seafield Street                               St Thomas Street
Edinburgh EH6 7LN                             London SE1 9RT
robandfiona@rfarley.fsnet.co.uk               Adam.Shortland@gstt.nhs.uk




                                        15
           Biophotonics: Technology and Applications
                    7th December 2006 (Half day meeting)
                  Instrument Science and Technology Group
                         Institute of Physics, London

Introduction

In recent years, there is growing evidence that breaking the barriers between
traditional academic disciplines can lead to truly ground-breaking scientific
developments. One area which has benefited from such cross-disciplinary
interaction is biophotonics, where photonics technologies are developed
specifically to address fundamental challenges in the life sciences. Light
presents a truly minimally invasive method for investigating biological media
and new biophotonics technologies and applications are rapidly emerging.

Programme

13:00 Refreshments on arrival

13.30 Photoacoustic imaging in biological tissue: features and issues
      T Li, G Gondek, R J Dewhurst. Centre for Instrumentation and Analytical
      Science, CEAS, University of Manchester, M60 1QD.

13.50 Structured illumination fluorescence microscopy
      L. Hirvonen, O. Mandula, Y. Colpin, R. Heintzmann. Randall Division of
      Cell and Molecular Biophysics, King's College London, New Hunt's
      House, Guy's Campus, London SE1 1UL.

14:10 Third-harmonic generation (THG) microscopy of developing embryos:
      structure sensitivity and phototoxicity
      D. Débarre1, W. Supatto2, E.Farge3, and E. Beaurepaire2. 1 Scanning
      optical microscopy group, Department of Engineering Science, University
      of Oxford. 2 Laboratory for Optics and Biosciences, CNRS-INSERM,
      Ecole Polytechnique, Palaiseau, France. 3 Laboratory of Physico-
      Chemistry of Life, CNRS, Institut Curie, F-75005 Paris, France.

14:30 The study of molecular diffusion in a sol-gel derived medium using
      Fluorescence recovery after photobleaching (FRAP) and Time-resolved
      fluorescence anisotropy
      C. Tregidgo, K. Suhling, G. Hungerford1, A. Rei1, I. Ferriera1. Physics
      Department, King's College London, Strand, London, WC2R 2LS, UK.
      1 Departamento de Física, Universidade do Minho, 4710-057 Braga,
      Portugal.




                                       16
14:50 Development of FRET spectroscopy for the study of cyclin-cdk
      interactions in living cells
      A.D. Elder, A. Domin, J. Pines1, and C.F. Kaminski. Department of
      Chemical Engineering, University of Cambridge, UK. 1 Wellcome/CR UK
      Institute of Cancer & Developmental Biology, University of Cambridge,
      UK.

15:10 A white light confocal microscope for spectrally resolved
      multidimensional imaging
      J.H. Frank1, A.D. Elder, and C.F. Kaminski. Department of Chemical
      Engineering, University of Cambridge, UK. 1 Sandia National
      Laboratories, Livermore, USA.

15.30 Refreshments

15:50 Laser speckle imaging for measuring blood flow
      D. Briers. Emeritus Professor of Applied Optics, Kingston University,
      Kingston upon Thames, UK.

16:10 Laser-assisted transfection of mammalian cells
      B. Agate, D. Stevenson, L. Paterson, W. Sibbett, F. Gunn-Moore, and K.
      Dholakia. Interdisciplinary Centre for Medical Photonics, University of
      St Andrews, Fife, Scotland.

16:30 Optically guided neuronal growth at near infra-red wavelengths
      D. J. Stevenson, D. Carnegie, T. K. Lake, B. Agate, V. Garcés-Chávez, K.
      Dholakia and F. Gunn-Moore. Interdisciplinary Centre for Medical
      Photonics, University of St Andrews, Fife, Scotland.

16:50 Application of novel Opsins in photostimulation of neural cells
      N. Grossman, K. Nikolic, P. Degenaar and C. Toumazou. Institute of
      Biomedical Engineering, Imperial College London, The Bessemer
      Building, London SW7 2AZ.

17:10 The Sensors Knowledge Transfer Network
      N. Day. Sensors KTN, Qi3, St John's Innovation Centre, Cowley Road,
      Cambridge, CB4 0WS.




                                      17
Further information from:

Dr Gail McConnell

Centre for Biophotonics
Strathclyde Institute for Biomedical Sciences
University of Strathclyde
27 Taylor Street
Glasgow
G4 0NR
Tel: 0141 548 4805
g.mcconnell@strath.ac.uk

or

Professor Andy Augousti
School of Life Sciences
Kingston University
Penrhyn Road
Kingston
Surrey
KT1 2EE
Tel: 0208 547 7480
augousti@kingston.ac.uk




Dates for your diary

2006

29 Oct. - 4 Nov.   San Diego, California. 2006 IEEE Nuclear Science
                   Symposium, Medical Imaging Conference
                   Website: http://www.nss-mic.org/2006/
                   E-mail: nssmic2006@bnl.gov

13 – 15th Nov.     Vienna, Austria. International Conference on Quality
                   Assurance and New Techniques in Radiation Medicine
                   (QANTRM).
                   Website: http://www-pub.iaea.org/MTCD/Meetings
                                      /Announcements.asp?ConfID=146
                   E-mail: qantrm@iaea.org




                                       18
3rd – 8th Dec.     Brisbane, Australia. Australian Institute of Physics 17th
                   National Congress
                   Website: http://www.aipc2006.com
                   Email: aipc2006@icms.com.au

2007

25th Jan.          York, UK. Human Shape: How can measurements and
                   modelling improve outcomes for patients with profound
                   abnormalities of posture?
                   Email: meetings@ipem.ac.uk

04-07th June       Toronto, Canada. XVth Int'l Conference on the Use of
                   Computers in Radiation Therapy.
                   Website: http://www.iccr2007.org/
                   E-mail: iccr@rmp.uhn.on.ca

Items for the Newsletter
The Newsletter is published quarterly; this edition covers the months October
through December 2006.

If you would like to make a contribution to the January to March 2007
Newsletter, e.g. news items, meeting reports, diary dates, letters, poems etc.,
please send them to:

Adam Gibson,
Department of Medical Physics and Bioengineering,
University College London, WC1E 6BT.
Tel: 020 7679 0279
E-mail: agibson@medphys.ucl.ac.uk

Closing date for submissions: 29th December 2006.




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