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INTRODUCTION TO DEVELOPMENTAL BIOLOGY (002:104)
COURSE SYLLABUS, FALL 2003
INSTRUCTORS: Dr. Diane C. Slusarski Dr. Joseph Frankel
Office: 312 Biology Building (BB) Office: 421 BB
Phone: 335-3229 Phone: 335-1110
Email: diane-slusarski@uiowa.edu joseph-frankel@uiowa.edu
TEACHING ASSISTANT: David Yen
Office: 315 Biology Building (BB)
Phone: 335-3997 (email contact preferred)
Email: hsan-jan-yen@uiowa.edu
This course is offered through the Department of Biological Sciences.
Contact Info: Jack Lilien, DEO Office: 141 BB Phone: 335-1054
TEXTBOOK (REQUIRED): Principles of Development, 2nd Edition by Lewis Wolpert.
ANCILLARY READINGS: These will be placed on reserve in the Biological Sciences Library (120 Iowa
Ave). Some Textbooks on reserve: Alberts et al., Molecular Biology of the Cell, for MCB background and
Developmental Biology, by Scott F. Gilbert.
OFFICE HOURS: (note: You may e-mail us with questions at any time)
Dr. Slusarski: 12-1:30PM Mon., 2:30-4:00PM Thurs., after class or by appointment.
David Yen: 2:30-4:30PM Tues. (314 BB), 12-1PM Thurs. or by appointment.
Dr. Frankel: MWF 1:30-2:30 PM or after class.
COURSE OBJECTIVES: Students will become familiar with patterns and mechanisms of
animal development, with an emphasis on model organisms. Stages of embryogenesis,
morphogenesis, pattern formation and differentiation of developing organisms will be examined.
Developmental mechanisms, especially at a molecular and cellular level, will be examined for
differences and commonality among organisms. The relationships between developmental
mechanisms and the molecular genetic basis of human disease will be examined and discussed.
It will be assumed that the students enrolled in the course have a basic knowledge of genetics,
cell and molecular biology.
COURSE ORGANIZATION AND POLICIES
1. Lectures: Lectures are on Tuesday and Thursday from 1:05-2:20 PM in Room 101 Biology
Building East (BBE). Attendance at all lectures is strongly recommended. This course is designed to
introduce you to the basic principles and processes of developmental biology. The lectures will cover only
selected topics from the text chapters, supplemented by additional material from many other sources. Lecture
topics are outlined in the accompanying schedule. Reading assignments and adjustments to the lecture schedule
will be announced in class and posted on the course web page. Some Course materials will be posted on the
course web site, see section 7.
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2. Weekly Review Sessions: Beginning in the second week of class, Mr. David Yen will
conduct a weekly review session on Friday at 2PM in 102 BSL (Biological Sciences Library). Students are
encouraged to attend the session to ask questions for clarification and to seek additional assistance when
needed. Any changes and/or additional sessions will be announced in lecture.
3. Exams: There will be two midterm exams (100 points each) during the regularly scheduled
class period, and a final exam (100 points) (location determined by the registrar). Consult the class schedule
and mark these dates. You will be responsible for all material covered in the lectures and assigned readings.
Past years exams were a combination of multiple choice, matching, true/false, short answer and essay questions.
The bulk of the exam material is typically in essay format.
IMPORTANT NOTE: If you do not participate in an exam this means you receive a zero-score on that exam.
Make-up exams will be given only if you bring a physician's statement -or- evidence of some event beyond
your control which compromised your preparation for or attendance at the scheduled exam (official
documentation explaining why you were unable to participate will be required). Such make-up exams may
be oral.
4. Course Grades: There will be a total of 300 points to be distributed as follows:
Exam I (30-Sep) 100 points Final Exam (16-Dec) 100 points
Exam II (5-Nov) 100 points
If the course mean at the end of the semester is 75% (225/300), grades will be assigned approximately as
follows:
A+ 98-100% B 83-86% C- 70-72%
A 93-97% B- 80-82% D+ 67-69%
A- 90-92% C+ 77-79% D 63-66%
B+ 87-89% C 73-76% D- 60-62%
F Below 60%
If the course mean falls below 75%, a normalized distribution curve will be used with the average score being a
C.
5. Other Concerns: I would like to hear from anyone who has a disability which may require
modification of seating, testing or other class requirements so that appropriate arrangements can be made.
Please see me during office hours.
6. Study Skills: For each semester hour credit in the course, students should expect to spend
two hours per week preparing for class sessions (e.g., for this 3-credit-hour course, standard out-of-class
preparation is 6 hours). Tests will strongly emphasize lecture material. Assigned readings contain more
material than will be covered in lecture. During class pay attention and take complete and orderly notes. Very
soon after class you should re-read the text material along with your notes. You may find you missed something
in lecture or the text, and very frequently you may find misspellings in your notes. Make frequent use of your
text glossary and index for further explanations on a subject you still don't understand. Feel free to ask the
instructor or TA to clear up any questions you may still have.
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7. Course Web Page
Information on the web page will include:
The syllabus and class schedule
Information from the lectures (Mainly figures and lecture outlines)
Assigned papers relevant to lecture
Old exams
Other items relevant to the course may be added and will be announced in class
How to get onto the page?
First, Log on to the department's web site: http://www.biology.uiowa.edu/
Then click on the following links:
Undergraduate Program
Class Notes/Syllabi
2:104 Developmental Biology
USERNAME: Provided in lecture
PASSWORD:
If you have technical difficulties downloading or viewing files, contact Mr. Brockman. matthew-
brockman@uiowa.edu
Student Rights and Responsibilities:
"All students in the College have specific rights and responsibilities. You have the right to adjudication of any
complaints you have about classroom activities or instructor actions. Information on these procedures is
available in the Schedule of Courses and on-line in the College's Student Academic Handbook
(http://www.clas.uiowa.edu/students/academic_handbook/). You also have the right to expect a classroom
environment that enables you to learn, including modifications if you have a disability."
"Your responsibilities to this class-and to your education as a whole-include attendance and participation. (Here
an instructor could put specific information on his/her or the department's attendance policy.) You are also
expected to be honest and honorable in your fulfillment of assignments and in test-taking situations (the
College's policy on plagiarism and cheating is on-line in the College's Student Academic Handbook
http://www.clas.uiowa.edu/students/academic_handbook/). You have a responsibility to the rest of the class-and
to the instructor-to help create a classroom environment where all may learn. At the most basic level, this means
that you will respect the other members of the class and the instructor, and treat them with the courtesy you
hope to receive in turn." As quoted from the CLAS Faculty Handbook
Good Luck and have a Great Semester!
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FALL 2003 LECTURE AND EXAM SCHEDULE
Note: Changes in topic or text readings will be announced in class and posted on the course web page.
DAY/DATE LECTURE TOPIC READING MATERIAL
Tu, 26-Aug 1. Course Overview/Embryological Concepts Chap1:1-15
Th, 28-Aug 2. Molecular and Cellular Review/Germ Cells 292-304, 429-36, 469-71
Tu, 02-Sep 3. Fertilization I 18-21, 429-444
Th, 04-Aug 4. Fertilization II papers supplied on web page
Tu, 09-Sep 5. Egg activation/ Cleavage 65-72, 87-89, 300-304, 435-444
Th, 11-Sep 6. No lecture to allow you to attend Heart Development Seminar (Details TBA)
Tu, 16-Sep 7. Cleavage II /Genomic Equivalence 15-18, 27-35, 41-46, 77-79, 83-89, 253-264
Th, 18-Sep 8. Gastrulation 27-35, 95-96, 201-203, 265-277, 281-282
Tu, 23-Sep 9. Gastrulation/Axis Formation 27-35, 65-73, 83-89, 271-276
Th, 25-Sep 10. Axis Formation II 73-76, 89-105
Tu, 30-Sep 11. EXAM I on material covered in lecture/readings #1-10
Th, 02-Oct 12. Neurulation and ectodermal derivatives 29-30, 109-110, 125-133, 253-258, 276-280
Tu, 07-Oct 13. Patterning of the Nervous system 375-390
Th, 09-Oct 14. Nervous system/Growth Cone/Axon Guidance 375, 394-403
Tu, 14-Oct 15. Ectodermal derivatives: eye/skin 321-322, 326-327, 393-394, 404-414
Th, 16-Oct 16. Ectoderm wrap up/ Mesoderm Derivatives 109-125, 317-319
Tu, 21-Oct 17. Mesoderm Derivatives 114-116, 304-307, 325-326, 473-477
Th, 23-Oct 18. Endodermal derivatives/ Organogenesis TBA
Tu, 28-Oct 19. Organogenesis/ Development and Cancer TBA
Th, 30-Oct 20. Wnt signaling in zebrafish development: a research overview
Tu, 04-Nov 21. EXAM II on material covered in lecture/readings #12-20
Th, 06-Nov 22. Pattern formation; Drosophila A-P axis I 18-25, 48-52, 143-150, 154, 161-165
Tu, 11-Nov 23. Drosophila AP (anteroposterior) axis II 166-177
Th, 13-Nov 24. Patterning the Drosophila wing imaginal disc 51 (Fig. 2.34), 170-174, 350-354, 359
Tu, 18-Nov 25. Drosophila segmental identity; homeotic genes 182-187, 356-358
Th, 20-Nov 26. Patterning of the vertebrate limb I: chicken 331-343
Tu, 25-Nov THANKSGIVING BREAK
Th, 27-Nov THANKSGIVING BREAK
Tu, 02-Dec 27. Patterning the vertebrate limb II: mouse & human 343-345
Th, 04-Dec 28. Evolution of limb development 493-511
Tu, 09-Dec 29. Limb regeneration 447-455
Th, 11-Dec 30. Embryonic and adult stem cells 21-22, 77-78, 307-309, 317-319
Tu, 16-Dec FINAL EXAM at 12 Noon LOCATION WILL BE ASSIGNED IN NOVEMBER
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