Introduction to GENETICS Instructor: Gilchrist Office HNS 109 Room CHAE Office Hours: M 9:00- 10:30 am, online chat 9-10 pm M, others by appt (voicemail 487-4275 or email email@example.com) Text: Concepts of Genetics by Klug, Cummings, and Spencer (8th edition) webBoard address: webboard.ncf.edu/~SandraGilchrist Genetics is a fascinating field of inquiry that has become a topic of daily conversation. New molecular techniques have helped to unlock the human genome and to reveal new challenges for scientists and for the public. Scientific discovery and ethical considerations are intertwined in the study of genetics. In this class, we will examine some of the classical underpinnings of the science including cultural influences on directions of study. After gaining confidence in basic materials, students will be introduced to molecular genetics through readings in the text and through the primary literature. Critical thinking (http://www.austhink.org/critical/) skills will be developed for different media and there will be an emphasis on improving communication skills. Evaluations will be based upon 5 criteria: quizzes, homework problems (3 sets), two problem-based projects, a final project, and class participation (work in groups, webBoard discussions, etc). THERE IS AN EMPHASIS ON ACTIVE LEARNING AND GROUP WORK, SO IF THESE ARE NOT PART OF YOUR LEARNING STYLE, CAREFULLY CONSIDER TAKING THIS CLASS. The final project will be a powerpoint presentation on a topic of student choice related to class material; students will work in groups of 2 or 3. Each presentation will be up to 10 minutes with up to 5 minutes of questions (total 15minutes) and should have an accompanying annotated bibliography. Webpages can constitute no more than 10% of the bibliography. You can check the class website for information on how to do citations and for general writing guidelines. Each student will be expected to participate in webBoard discussions of topics and problems, thus it is necessary for students to have an email account to log on to the Board. Instructions on using the Board will be given in class and will be associated with the class webpage www.ncf.edu/gilchrist at the icon for genetics 2007. Library readings are recommended to supplement class materials. Students with specific needs for taking quizzes are expected to notify me in advance so that appropriate arrangements can be made. NO LATE WORK WILL BE ACCEPTED FOR CLASS CREDIT. Evaluation activities ARE DUE ONE WEEK FROM THE DATE ASSIGNED UNLESS OTHERWISE NOTED. Academic dishonesty is not acceptable in any form. Check for problem set guidelines at class website. The following is a tentative schedule. We may adjust schedule relative to interests and levels of participants in class. Chapters for reading in the text are indicated along with outside readings. Library readings can be found through the virtual library. Week # Topic Reading 1 Background/review and DNA structure ch 1-9 review before class; ch 10 2-3 Replication, recombination and organization ch 11-12 and libr 1; Problem set 1 4 QUIZ Th Introduction to expression ch 13; problem based project 1 5-6 Mutation and regulation ch 14-17; libr 2; Problem set 2 Introduction to RefWorks 7 QUIZ Th Gene Expression and Regulation ch 18 ; ppoint topic due B R E A K B R E A K BR E A K 9-10 Genomic analysis ch 19-20; Problem set 3; 11 Gene Function and applications of biotechnology ch 21-22; presentation outline due Th of week 12 12 QUIZ Th Developmental genetics ch 23-24; problem based project 2 13 Populations and evolution ch 24-26; libr 3 14 Conservation/catch up ch 27 15 Final Project presentations/wrap up You are responsible material in the readings for quizzes, class discussions, and other activities. Online references of interest http://www.wormbook.org/ http://www.dharmacon.com/ Supplementary papers Library 1 Sutter, et al. 2007. A single IGF1 Allele is a Major Determinant of Small Size in Dogs. Science 316:112 and Heeney, et al. 2006. Origins of HIV and the Evolution of Resistance to AIDS. Science 313: 462-66. Library 2 Whibley, et al. 2006. Evolutionary Paths Underlying Flower Color Variation in Antirrhinum. Science 313: 963-966 and Gibb, et al., 2007. Evolutionary and Biomedical Insights from the Rhesus Macaque Genome. Science 316: 222-237. Library 3 Whitfield, et al., 2006. Thrice Out of Africa: Ancient and Recent Expansions of the Honey Bee, Apis mellifera. Science 314: 642-645.