NSF-NIEHS Centers for Oceans and Human Health - Novel integration of NIH and NSF. - Stimulated by scientific community, and by CORE, an NRC report, and the Directors of NSF and NIEHS. - Focus on HAB, pathogens, pharmaceuticals, - Integrate biological / oceanographic approaches. NSF-NIEHS Centers for Oceans and Human Health - Joint Request for Applications (RFA) - Competitive review of Center grant applications. - 20 plus applications - Four Centers funded: -Washington -Hawaii -Woods Hole Woods Hole Center for Oceans and Human Health Integrated effort by three Institutions: Woods Hole Oceanographic Inst. Marine Biological Laboratory Massachusetts Inst. of Technology Woods Hole Center for Oceans and Human Health COHH Director J. Stegeman Deputy Director D. Mcgillicuddy Internal Advisory External Advisory Committee Committee Administrator WHOI Administration RESEARCH GENOMICS PILOT PROJECTS FACILITY CORE PROJECTS D. Anderson D. Mcgillicuddy D. Erdner M. Sogin S. Hajduk H. Morrison M. Hahn R. Gast M.Polz L. Amaral-Zettler J. Lerczak Research Focus Harmful algal blooms (2 projects) Infectious agents (2 projects) Temperate Coastal Waters New England waters as a model system. Woods Hole Center for Oceans and Human Health Administrative Core Stegeman McGillicuddy Advanced Population Coastal Genomics Biology Hydrodynamics Core Facility 1. Anderson: HABs 2. McGillicuddy: HABs Sogin Morrison 3. Gast and Amaral-Zettler: Infectious Diseases 4. Polz and Lerczak: Infectious Diseases Pilot Projects Director: Hajduk co-Director: Hahn WHOI MBL MIT Woods Hole Center for Oceans and Human Health Other EHS Institutes Centers Other COHH & Centers Human Pathogens in the Environment -reservoirs ? -favorable growth -Gene transfer environmental Shellfish poisoning, amplification transport toxicosis…. understanding ecology = understanding risk --> prediction and prevention Mt. Hope Bay Heavily impacted by humans – Sewage outfalls, industrial waste, thermal discharge Mt. Hope Bay Natural Laboratory – Centralized data bases – Predictive current models under development – No microbial or pathogen sampling program Proxy for other New England bays Vibrio infections - a worldwide problem Environmental reservoirs, WH-COHH Vibrio project routes of transmission and infection • Understand • Predict Wound, eye and ear infection: • Protect - rising worldwide - numbers not well known - Environmental prevalence and growth factors - Gene transfer and evolution - Risk assessment V. vulnificus V. parahaemolyticus Seafood consumption: - up to 10,000 infections/yr in US and reports of infection rising (CDC); - 95% of all seafood related deaths Human Pathogens: Presence & Persistence in the Coastal Marine Environment Studies of traditionally non-marine human pathogens in coastal marine waters: Essential to determine their potential to impact human health Evidence and vectors Sea otters, whales, and shellfish can (Giardia) harbor protistan pathogens such as Giardia and Cryptosporidium – Shellfish and protists (such as Acanthamoeba) can harbor bacterial pathogens such as Legionella and Vibrio, and enhance pathogenicity. (Legionella in amoeba) HAB threats to human health in temperate waters of the northeastern U.S. Woods Hole COHH HAB projects • Overall objective: to link dinoflagellate population structure, physiology, and toxicity in order to improve prediction and prevention of HABs. • Rationale: cellular toxicity varies with environmental and genetic factors; cell number is not always a good proxy for toxicity Genotype Physical-biological Physiology coupled model Toxicity Paralytic shellfish poisoning (PSP) • causes paralysis and death; • causative organism Alexandrium fundyense (dinoflagellate); • widespread and recurrent annual problem; • ongoing shellfish monitoring programs in ME, NH, MA, CT Germination Germination, Growth Germination, Growth, Only &Mortality Mortality & Nutrient lim. May Jun Jul Aug Woods Hole Center for Oceans and Human Health Pilot Project Program Steve Hajduk (MBL), Director Mark Hahn (WHOI), Deputy Director 2004 Call for Proposals Pilot Project Program Objectives • Support short-term projects to assess feasibility of new research topics • Generate preliminary data • Expand scope of Center research • Expand participation in Center Pilot Project Program Areas of emphasis • Harmful algal blooms (HABs) • Water- and vector-borne diseases • Marine-derived pharmaceuticals and probes RFP: http://grants1.nih.gov/grants/guide/rfa-files/RFA-ES-03-003.html NRC/NAS (1999) From Monsoons to Microbes: Understanding the Ocean’s role in Human Health NSF/NIEHS Oceans and Human Health roundtable report, December 2001 Pilot Project Program Eligibility • MBL, MIT, WHOI Scientific and Sr. Technical Staff Pilot Project Program Budgets • up to $50K direct costs • 1 year + no-cost extension if needed • Earliest start date: October 1, 2004 • Salaries • Supplies • Student stipend and tuition • Equipment - not usually • Travel - meetings: No • Travel - sample collection: If strongly justified • Ship time - if strongly justified Pilot Project Program Pre-proposal (required) • Due July 15, 2004 • 1 page summary of project • Direct and indirect costs • 2p CV/Biosketch for PI and other key personnel (NSF or NIH format) • Submit electronically: Steve Hajduk, MBL (email@example.com) or Mark Hahn, WHOI (firstname.lastname@example.org) Pilot Project Program Full proposals • Due August 15, 2004 at 5 PM EDT. • Title page • Research Plan (5 pp.) a) Objectives b) Background & Rationale c) Experimental design and methods d) Facilities available and/or use of genomics core e) Relevance to COHH program f) Broader impacts (see NSF guidelines) g) References (not included in 5p limit) • Budget (Direct and indirect costs) • Budget justification (1 p) • 2p CV/Biosketch for PI and other key personnel(NSF/NIH format) • Other support (Key personnel; NIH or NSF format) • Human subject / Vertebrate animal approvals • Submit hard copy (1) and electronically Pilot Project Program Review • Phase I - Woods Hole COHH Internal Advisory Committee (IAC) - outside reviewers (EAC) as needed - Written critiques • Phase II - presentations (10 min) to IAC Pilot Project Program Review criteria • Scientific merit • Relevance and potential impact • Innovation • Investigators • Facilities • Broader impacts Pilot Project Program Questions? Model run: cyst germination plus growth and mortality Present model assumes that all Alexandrium fundyense cells are the QuickTime™ and a BMP decomp resso r are neede d to see this picture. the same (i.e., same growth rate, nutrient responses, toxicity, motility, etc.) Will address different strains known to exist. Woods Hole COHH • Addressing public health issues. • Incorporating advanced genomic studies and oceanography.