CURRICULUM VITAE

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					                                          CURRICULUM VITAE*

NAME:                         Robert H. Allen, M .D.

TITLE:                        Professor of Medicine
                              Co-Director, Division of Hematology

BIRTHPLACE:                   Detroit, Michigan

PRESENT ADDRESS:              University of Colorado Health Sciences Center
                              Department of Medicine/Division of Hematology
                              4200 E. 9th Avenue, Campus Box B-170
                              Denver, CO 80262

CITIZENSHIP:                  U. S. Citizen

MARITAL STATUS:               Married, two children

EDUCATION:        Amherst College, Amherst, Massachusetts - B. A., Magna Cum Laude - 1960
                  University of California, Berkeley, California (1961-1962)
                  Washington University School of Medicine, St. Louis, Missouri - M. D. - 1966

LICENSURE:   Missouri, 1966
             Colorado, 1977
ACADEMIC APPOINTMENTS:
1966-1967     Intern in Medicine, Parkland Memorial Hospital, Dallas, Texas
1967-1969     Staff Associate, National Institute of Arthritis, Metabolism and Digestive Diseases,
              Bethesda, Maryland
1969-1970     Senior Resident in Medicine, Barnes Hospital, St. Louis, Missouri
1970-1972     Fellow in Hematology/Oncology, Washington University School of Medicine, St.
Louis,        Missouri
1972-1975     Assistant Professor of Medicine, Washington University School of Medicine, St. Louis,
              Missouri
1975-1977    Associate Professor of Medicine, Washington University School of Medicine, St. Louis,
             Missouri
1977-Present Professor of Medicine, University of Colorado Health Sciences Center, Denver,
             Colorado
1977-1998    Director, Division of Hematology, University of Colorado Health Sciences Center,
             Denver, Colorado
1980-1995     Professor of Biochemistry, University of Colorado Health Sciences Center, Denver,
              Colorado
1992-Present  Cleo Meador and George Ryland Scott Professor of Hematology Research, University
               of Colorado Health Sciences Center, Denver, Colorado
1998-Present   Co-Director, Division of Hematology, University of Colorado Health Sciences Center,
               Denver, Colorado



   Updated 3/22/06
MAJOR SCIENTIFIC INTEREST: Cobalamin (vitamin B12), and folate metabolism and deficiency

OTHER ACTIVITIES AND HONORS:
1966          Richard S. Brookings Research Prize, Washington University School of Medicine
1974-1978     American Cancer Society Faculty Research Award
1975-1977     Member, Veterans Administration Hematology Study Section
1977          Chairman, Veterans Administration Hematology Study Section
1976-1979     Member, Editorial Board, Blood
1977          Secretary-Treasurer, National Blood Club
1979          President, Western Blood Club
1979-1982     Member, National Committee for Clinical Laboratory Standards (NCCLS) Task Force
              on Vitamin B12 Assay
1979-1984     Member, Educational Committee of the Journal of Clinical Investigation
1986          MERIT Award, National Institute of Diabetes and Digestive and Kidney Diseases, NIH
1990          SmithKline Beecham Laboratories Award of the Clinical Ligand Assay Society
1992          Vice-Chairman, FASEB Summer Research Conference on Folic Acid, Vitamin B12 and
              One Carbon Metabolism, Saxtons River, Vermont
1994          Chairman, FASEB Summer Research Conference on Folic Acid, Vitamin B12 and One
              Carbon Metabolism, Copper Mountain, Colorado

PROFESSIONAL SOCIETY MEMBERSHIPS:
     Phi Beta Kappa
     Alpha Omega Alpha
     Sigma Xi
     Association of American Physicians
     American Clinical and Climatological Association
     American Society for Clinical Investigation
     American Society of Hematology
     American Society of Biological Chemists
     American Federation for Clinical Research
     Western Society for Clinical Research
     Western Association of Physicians

OTHER INFORMATION:
     Board Certification in Internal Medicine, 1974
     Board Certification in Hematology, 1976
                                             BIBLIOGRAPHY

1. Kohn, Leonard D., Packman, Paul M., Allen, Robert H., Jakoby, William B. Tartaric acid
    metabolism V. Crystalline tartrate dehydrogenase. J Biol Chem 243:2479-85, 1968.
2. Allen, Robert H. and Jakoby, William B. Tartaric acid metabolism. IX. Synthesis with tartrate
    epoxidase. J Biol Chem 244:2078-84, 1969.
3. Allen, Robert H. and Majerus, Philip W. Isolation of vitamin B12-binding proteins using affinity
    chromatography. I. Preparation and properties of vitamin B12-sepharose. J Biol Chem 247:7695-
    7701, 1972.
4. Allen, Robert H. and Majerus, Philip W. Isolation of vitamin B12-binding proteins using affinity
    chromatography. II. Purification and properties of a human granulocyte vitamin B12-binding protein.
    J Biol Chem 247:7702-08, 1972.
5. Allen, Robert H. and Majerus, Philip W. Isolation of vitamin B12-binding proteins using affinity
    chromatography. III. Purification and properties of human plasma transcobalamin II. J Biol Chem
    247:7709-17, 1972.
6. Allen, Robert H., and Mehlman, Carol S. Isolation of gastric vitamin B12-binding proteins using
    affinity chromatography. I. Purification and properties of human intrinsic factor. J Biol Chem
    248:3660-69, 1973.
7. Allen, Robert H., and Mehlman, Carol S. Isolation of gastric vitamin B12-binding proteins using
    affinity chromatography. II. Purification and properties of hog intrinsic factor and hog nonintrinsic
    factor. J Biol Chem 248:3670-80, 1973.
8. Fjellstedt, Thorsten A., Allen, Robert H., Duncan, Bruce K., Jakoby, William B. Enzymatic
    conjugation of epoxides with glutathione. J Biol Chem 248:3702-07, 1973.
9. Hooper, David C., Alpers, David H., Burger, Robert L., Mehlman, Carol S., Allen, Robert H.
    Characterization of ileal B12-binding protein using homogeneous human and hog intrinsic factors. J
    Clin Invest 52:3074-83, 1973.
10. Allen, Robert H., Burger, Robert L., Mehlman, Carol S., Majerus, Philip W. Affinity techniques.
    Enzyme Purification: Part B. Vitamin B12. Methods Enzymol XXXI:305-14, 1974.
11. Burger, Robert L. and Allen, Robert H. Characterization of vitamin B12-binding proteins isolated
    from human milk and saliva by affinity chromatography. J Biol Chem 249: 7220-27, 1974.
12. Katz, Max, Mehlman, Carol S., Allen, Robert H. Isolation and characterization of an abnormal
    human intrinsic factor. J Clin Invest 53:1274-83, 1974.
13. Burger, Robert L., Mehlman, Carol S., Allen, Robert H. Human plasma R-type vitamin B12-binding
    proteins. I. Isolation and characterization of transcobalamin I, transcobalamin III, and the normal
    granulocyte vitamin B12-binding protein. J Biol Chem 259:7700-06, 1975.
14. Burger, Robert L., Schneider, Robert J., Mehlman, Carol S., Allen, Robert H. Human plasma R-type
    vitamin B12-binding proteins. II. The role of transcobalamin I, transcobalamin III, and the normal
    granulocyte vitamin B12-binding protein in the plasma transport of vitamin B12. J Biol Chem
    250:7707-13, 1975.
15. Burger, Robert L., Waxman, Samuel, Gilbert, Harriet S., Mehlman, Carol S., Allen, Robert H.
    Isolation and characterization of a novel vitamin B12-binding protein associated with hepatocellular
    carcinoma. J Clin Invest 56:1262-70, 1975.
16. Allen, Robert H. Human vitamin B12 transport proteins. Prog Hematol 9:57-84, 1975.
17. Schneider, Robert J., Burger, Robert L., Mehlman, Carol S., Allen, Robert H. The role and fate of
    rabbit and human transcobalamin II in the plasma transport of vitamin B12 in the rabbit. J Clin Invest
    57:27-8, 1976.
18. Allen, Robert H. Vitamin B12-binding proteins in human plasma. Prog Clin Biol Res 5:357-75,
    1976.
19. Allen, Robert H. The plasma transport of vitamin B12. Br J Haematol 33:161-71, 1976.
20. Kane, SP, Hoffbrand, AV, Allen, RH, Neale, G. A familial abnormality of circulating vitamin B12-
    binding proteins: Occurrence in a family of high serum concentrations of transcobalamin II. Br J
    Haematol 33:249-59, 1976.
21. Jacob, Elizabeth, Herbert, Victor, Burger, Robert L., Allen, Robert H. Atypical plasma factor
    association with brochogenic carcinoma and complexing with R-type vitamin B12-binding proteins.
    NEJM 296:915-17, 1977.
22. Kolhouse, J. Fred and Allen, Robert H. Recognition of two intracellular cobalamin-binding proteins
    and their identification as methylmalonyl-CoA mutase and methionine synthase. PNAS 74:921-25,
    1977.
23. Kolhouse, J. Fred and Allen, Robert H. Absorption, plasma transport and cellular retention of
    cobalamin analogues in the rabbit. Evidence for the existence of multiple mechanisms that prevent the
    absorption and tissue dissemination of naturally occurring cobalamin analogues. J Clin Invest 61:47-
    54, 1978.
24. Kolhouse, J. Fred and Allen, Robert H. Isolation of cobalamin and cobalamin analogs by reverse
    affinity chromatography. Anal Biochem 84:486-90, 1978.
25. Allen, Robert H., Seetharam, Bellur, Podell, Elaine R., Alpers. David H. Effect of proteolytic
    enzymes on the binding of cobalamin to R protein and intrinsic factor. In Vitro evidence that a failure
    to partially degrade R protein is responsible for cobalamin malabsorption in pancreatic insufficiency.
    J Clin Invest 61:47-54, 1978.
26. Youngdahl-Turner, Pamela, Rosenberg, Leon E., Allen, Robert H. Binding and uptake of
    transcobalamin II by human fibroblasts. J Clin Invest 61:133-41, 1978.
27. Seligman, Paul A. and Allen, Robert H. Characterization of the receptor for transcobalamin II
    isolated from human placenta. J Biol Chem 253:1766-72, 1978.
28. Allen, Robert H., Seetharam, Bellur, Allen, Nancy C., Podell, Elaine R., Alpers, David H. Correction
    of cobalamin malabsorption in pancreatic insufficiency with a cobalamin analogue that binds with
    high affinity to R protein but not to intrinsic factor. In vivo evidence that a failure to partially degrade
    R protein is responsible for cobalamin malabsorption in pancreatic insufficiency. J Clin Invest
    61:1628-34, 1978.
29. Kolhouse, J. Fred, Kondo, Haruki, Allen, Nancy C., Podell, Elaine R., Allen, Robert H. Cobalamin
    analogues are present in human plasma and can mask cobalamin deficiency because current
    radioisotope dilution assays are not specific for true cobalamin. NEJM 299:785-92, 1978.
30. Youngdahl-Turner P, Mellman IS, Allen RH. and Rosenberg LD. Protein mediated vitamin uptake.
    Adsorptive endocytosis of the transcobalamin-cobalamin complex by cultured human fibroblasts. Exp
    Cell Res 118:127-34, 1979.
31. Seligman, Paul A., Schleicher, Rhoda B., Allen, Robert H. Isolation and characterization of the
    transferrin receptor from human placenta. J Biol Chem 255:9943-46, 1979.
32. Kolhouse, J. Fred, Utley, Carolyn S., Allen, Robert H. Isolation and characterization of
    methylmalonyl-CoA mutase from human placenta. J Biol Chem 255:2708-12, 1980.
33. Brugge, William R., Goff, John S., Podell, Elaine R., Allen Nancy C., Allen, Robert H.
    Development of a dual label Schilling test for pancreatic exocrine function based on the differential
    absorption of cobalamin bound to intrinsic factor and R protein. Gastroenterol 78:937-49, 1980.
34. Kondo, Haruki, Kolhouse, J. Fred, Allen, Robert H. Presence of cobalamin analogues in animal
    tissues. PNAS 77:817-21, 1980.
35. Seligman, Paul A. Steiner, LaDonna L., Allen, Robert H. Studies of a patient with megaloblastic
    anemia and an abnormal transcobalamin II. NEJM 303:1209-12, 1980.
36. Levine, Joel S., Nakane, Paul K., Allen, Robert H. Immunocytochemical localization of a human
    intrinsic factor: The nonstimulated stomach. Gastroenterol 79:493-502, 1980.
37. Kondo, Haruki, Osborne, Molly, Kolhouse J. Fred, Binder, Mitchell J., Podell, Elaine R., Allen,
    Robert H. Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes
    decreases in the activities of both mammalian cobalamin-dependent enzymes in rats. J Clin Invest
    67:1270-83, 1981.
38. Seetharam Bellur, Alpers, David H., Allen, Robert H. Isolation and characterization of the ileal
    receptor for intrinsic factor-cobalamin. J Biol Chem 256:3785-90, 1981.
39. Allen, Robert H. Clinical role and current status of serum cobalamin (vitamin B12) assays. Ligand
    Quarterly 4(3):37-45, 1981.
40. Zucker, Richard M., Podell, Elaine R., Allen, Robert H. Multiple problems with current no-boil
    assays for serum cobalamin. Ligand Quarterly 4(3):52-58, 1981.
41. Levine, Joel S. Nakane, Paul K., Allen, Robert H. Human intrinsic factor secretion:
    Immunocytochemical demonstration of membrane-associated vesicular transport in parietal cells. J
    Cell Biol 90:644-55, 1981.
42. Levine, Joel S. Nakane, Paul K., Allen, Robert H. Immunocytochemical localization of intrinsic
    factor-cobalamin bound to the guinea pig ileum in vivo. Gastroenterol 82:284-90, 1982.
43. Kondo, Haruki, Binder, Mitchell J., Kolhouse, J. Fred, Smythe, W. Rodman, Podell, Elaine R., Allen,
    Robert H. Presence and formation of cobalamin analogues in multivitamin-mineral pills. J Clin
    Invest 70:889-98, 1982.
44. Binder, Mitchell J., Kolhouse, J. Fred, Van Horne, Kenneth C., Allen, Robert H. High-pressure
    liquid chromatography of cobalamin and cobalamin analogs. Anal Biochem 125:253-58, 1982.
45. Friedman, Paul A., Weinsteine, Paul P. Mueller, Justus F., Allen, Robert H. Internal transport and
    metabolism of cobalamin in Spirometra mansonoides (cestoda) spargana. J Parasitol 68:983-92, 1982.
46. Allen, Robert H. Cobalamin (vitamin B12) absorption and malabsorption. View Digest Dis 14:17-
    20, 1982.
47. Friedman, Paul A., Weinstein, Paul P., Mueller, Justus F., Allen, Robert H. Characterization of
    cobalamin receptor sites in brush-border plasma membranes of the tapeworm Spirometra
    mansonoides. J Biol Chem 258:4261-65, 1983.
48. Seligman, Paul A., Caskey Jennifer H., Frazier, Janet L. Zucker, Richard M., Podell, Elaine R., Allen,
    Robert H. Measurements of iron absorption from prenatal multivitamin-mineral supplements. Obstet
    Gynecol 61:356-62, 1983.
49. Seligman, Paul A., Allen, Robert H., Kirchanski, Stefan J., Natale, Peter J. Automated analysis of
    reticulocytes using fluorescent staining with both acridine orange and an immunofluorescence
    technique. Am J Hematol 14:57-66, 1983.
50. Kovachy, Robin J., Copley, Shelley D., Allen, Robert H. Recognition, isolation, and characterization
    of rat liver D-methylmalonyl coenzyme A hydrolase. J Biol Chem 258:11415-21, 1983.
51. Levine, Joel S., Allen, Robert H., Alpers, David H., Seetharam, Bellur. Immunocytochemical
    localization of the intrinsic factor-cobalamin receptor in dog-ileum: Distribution of intracellular
    receptor during cell maturation. J Cell Biol 98:1111-18, 1984.
52. Ambruso, Daniel R. Sasada, Masataka, Nishiyama, Hideki, Bubo, Akemi, Komiyama, Atsushi, Allen,
    Robert H. Defective bactericidal activity and absence of specific granules in neutrophils from a
    patient with recurrent bacterial infections. J Clin Immunol 4:23-30, 1984.
53. Levine, Joel S. and Allen, Robert H. A retrospective immunohistochemical study. Gastroenterol
    88:1132-36, 1985.
54. Utley, Carolyn S., Marcell, Paul, Allen, Robert H., Antony, Asok C., Kolhouse, J. Fred. Isolation and
    characterization of methionine synthetase from human placenta. J Biol Chem 260:13656-65, 1985.
55. Stabler, Sally P., Marcell, Paul D., Allen, Robert H. Isolation and characterization of D, L-
    methylmalonyl-coenzyme A racemase from rat liver. Arch Biochem Biophys 241:252-64, 1985.
56. Marcell, Paul D., Stabler, Sally P., Podell, Elaine R., Allen, Robert H. Quantitation of
    methylmalonic acid and other dicarboxylic acids in normal serum and urine using capillary gas
    chromatography-mass spectrometry. Anal Biochem 150:85-66, 1985.
57. Yang, Yih-ming, Ducos, Rafael, Rosenberg, Allen J., Catrou, Paul G., Levine, Joel S., Podell, Elaine
    R., Allen, Robert H. Cobalamin malabsorption in three siblings due to an abnormal intrinsic factor
    that is markedly susceptible to acid and proteolysis. J Clin Invest 76:2057-65, 1985.
58. Stabler, Sally P., Marcell, Paul D., Podell, Elaine R., Allen, Robert H., Lindenbaum, John. Assay of
    methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas
    chromatography-mass spectrometry. J Clin Invest 77:1606-12, 1986.
59. Stabler SP, Marcell PD, Podell ER, Allen RH. Quantitation of total homocysteine, total cysteine, and
    methionine in normal serum using capillary gas chromatography-mass spectrometry. Anal Biochem
    162-185-96, 1987.
60. Seligman, Paul A. and Allen, Robert H. Isolation of transferrin receptor from human placenta.
    Methods Enzymol 147:239-47, 1987.
61. Bartholomew, Dennis W., Batshaw, Mark L., Allen, Robert H., Roe, Charles R., Rosenblatt, David,
    Valle, David L., Francomano, Clair A. Therapeutic approaches to cobalamin-C methylmalonic
    acidemia and homocystinuria. J Pediatr 112:32-39, 1988.
62. Stabler, Sally P., Marcell, Paul D., Podell, Elaine R., Allen, Robert H., Savage, David, Lindenbaum,
    John. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency
    detected by capillary gas chromatography-mass spectrometry. J Clin Invest 81:466-74, 1988.
63. Stabler, Sally P., Lindenbaum, John, Allen, Robert H. Failure to detect B-leucine in human blood or
    leucine 2,3 amino mutase in rat liver using capillary gas chromatography-mass spectrometry. J Biol
    Chem 263:5581-88, 1988.
64. Ledley, Fred D., Lumetta, Michele, Nguyen, Phi Nga, Kolhouse, J. Fred, Allen, Robert H. Molecular
    cloning of L -methylmalonyl-CoA mutase: Gene transfer and analysis of mut cell lines. PNAS
    85:3518-21, 1988.
65. Lindenbaum, John, Healton, Edward B., Savage, David G, Brust, John C.M., Garrett, Thomas J.,
    Podell, Elaine R., Marcell, Paul D., Stabler, Sally P., Allen, Robert H. Neuropsychiatric disorders
    caused by cobalamin deficiency in the absence of anemia or macrocytosis. NEJM 318:1720-28, 1988.
66. Elwood, Patric C., Reid, William K., Marcell, Paul D., Allen, Robert H., Kolhouse, J. Fred.
    Determination of the carbohydrate composition of mammalian glycoproteins by capillary gas
    chromatography/mass spectrometry. Anal Biochem 175:202-11, 1988.
67. Skidmore, Margaret D., Shenker, Nancy, Kliegman, Robert M., Shurin, Susan, Allen, Robert H.
    Biochemical evidence of asymptomatic vitamin B12 deficiency in children after ileal resection for
    necrotizing enterocolitis. J Pediatr 115:102-05, 1989.
68. Johnston, Jennifer, Bollekens, Jacques, Allen, Robert H., and Berlinger, Nancy. Structure of the
    cDNA encoding transcobalamin I, a neutrophil granule protein. J Biol Chem 264:15754-757, 1989.
69. Broxson, Emmett H., Jr., Stork, Linda C., Allen, Robert H., Stabler, Sally P., Kolhouse, J. Fred.
    Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate
    infusions. Cancer Res 49:5879-883, 1989.
70. Brass, Eric P., Allen, Robert H., Arung, Tahiliani, Stabler, Sally P. Coenzyme-A metabolism in
    vitamin B12 deficient rats. J Nutr 120:290-97, 1990.
71. Brass, Eric P., Allen, Robert H., Ruff, Laura J., Stabler, Sally P. Effects of hydroxycobalamin [c-
    lactam] on propionate and carnitine metabolism in the rat. Biochem J 266:809-15, 1990.
72. Allen, Robert H., Stabler, Sally P., Savage, David G., Lindenbaum, John. Diagnosis of cobalamin
    deficiency I: Usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J
    Hematol 34:90-98, 1990.
73. Lindenbaum, John, Savage, David G., Stabler, Sally P., Allen, Robert H. Diagnosis of cobalamin
    deficiency II: Relative sensitivities of serum cobalamin, methylmalonic acid and total homocysteine
    concentrations. Am J Hematol 34:99-107, 1990.
74. Stabler, Sally P., Allen, Robert H., Savage, David G., Lindenbaum, John. Clinical spectrum and
    diagnosis of cobalamin deficiency Blood 76:871-81, 1990.
75. Krahenbuhl S, Ray DB, Stabler SP, Allen RH, Brass EP. Increased hepatic mitochondrial capacity in
    rats with hydroxy-cobalamin [c-lactam]-induced methylmalonic aciduria. J Clin Invest 86:2054-61,
    1990.
76. Stabler, Sally P., Brass, Eric P., Marcell, Paul D., Allen, Robert H. Inhibition of rat cobalamin-
    dependent enzyme activity by cobalamin analogues. J Clin Invest 87:1422-30, 1991.
77. Stabler, Sally P., Allen, Robert H., Savage, David G., Lindenbaum, John. Cerebrospinal fluid
    methylmalonic acid levels in normal subjects and patients with cobalamin deficiency. Neurol
    41:1627-32, 1991.
78. Kolhouse, J. Fred, Utley, Carolyn, Allen, Robert H. Mechanism of conversion of human apo- to
    holomethionine synthase by various forms of cobalamin. J Biol Chem 266:23010-15, 1991.
79. Allen, Robert H. Megaloblastic anemias. In: Cecil Textbook of Medicine, 19th Edition, James B.
    Byngaarden, Lloyd H. Smith, Jr., J. Claude Bennett and Fred Plum (Eds.), W.B. Saunders Company,
    Orlando, FL, 1992, pp. 846-54.
80. Sundin, David P. and Allen, Robert H. Analysis of the nucleoside moiety of cobalamin and
    cobalamin analogues using gas chromatography-mass spectrometry. Arch Biochem Biophys 298:658-
    66, 1992.
81. Pennypacker, Leslye C., Allen, Robert H., Kelly, James P., Matthews, Mary, Grigsby, Jim, Kaye,
    Kathryn, Lindenbaum, John, Stabler, Sally P. High prevalence of cobalamin deficiency in elderly
    outpatients. JAGS 40:1197-1204, 1992.
82. Kolhouse, J. Fred, Stabler, Sally P., Allen, Robert H. Identification and perturbation of mutant
    human fibroblasts based on measurements of methylmalonic acid and total homocysteine in the
    culture media. Arch Biochem Biophys 303:355-60, 1993.
83. Allen, Robert H., Stabler, Sally P., Savage, David G., Lindenbaum, John. Elevation of 2-methylcitric
    acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiency.
    Metabolism 42:978-88, 1993.
84. Stabler, Sally P., Lindenbaum, John, Savage, David G., Allen, Robert H. Elevation of serum
    cystathionine levels in patients with cobalamin and folate deficiency. Blood 81-3404-13, 1993.
85. Allen, Robert H., Stabler, Sally P., Lindenbaum, John. Serum betaine, N, N-dimethylglycine and N-
    methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of
    metabolism. Metabolism 42:1448-60, 1993.
86. Joosten, Etieene, van den Berg, Annelise, Riezler, Reiner, Naurath, Hans J., Lindenbaum, John,
    Stabler, Sally P., Allen, Robert H. Metabolic evidence that deficiencies of vitamin B12 (cobalamin),
    folate and vitamin B6 occur commonly in elderly people. AJCN 58:468-76, 1993.
87. Savage, David G., Lindenbaum, John, Stabler, Sally P., Allen, Robert H. Sensitivity of serum
    methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate
    deficiencies. Am J Med 96:239-46, 1994.
88. Frontiera MS, Stabler SP, Kolhouse JF, Allen RH. Regulation of methionine metabolism: effects of
    nitrous oxide and excess dietary methionine. J Nutr Biochem 5:28-38, 1994.
89. Savage, David G., Gangaidzo, Innocent, Lindenbaum, John, Kiire, Clement, Mukiibi, Joshua, M.,
    Moyo, Alpha, Gwanzura, Christine, Mudenge, Boniface, Bennie, Anne, Sitima, John, Stabler, Sally P.,
    Allen, Robert H. Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in
    Zimbabwe. Br J Haem 86:844-50, 1994.
90. Lindenbaum, John, Rosenberg, Irwin, Wilson, Peter W.F., Allen, Robert H., and Stabler, Sally P.
    Prevalence of cobalamin deficiency in the Framingham elderly population. AJCN 60:2-11, 1994.
 91. White, Carl W., Stabler, Sally P., Allen, Robert H., Rosenberg, Adam A. Plasma cysteine
     concentrations in infants with respiratory distress. J Pediatr 125:769-77, 1994.
 92. Bostom, Andrew G., Shemin, Douglas, Nadeau, Marie R., Shih, Vivian, Stabler, Sally P., Allen,
     Robert H., Selhub, Jacob. Short-term betaine therapy fails to lower elevated fasting total plasma
     homocysteine concentrations in hemodialysis patients maintained on chronic folic acid
     supplementation. Atheroscler 113:129-32, 1995.
 93. Adams, Michael J. Jr., Khoury, Muin J., Scanlon, Kelly St., Stevenson, Roger E., Knight, George J.,
     Haddow, James E., Sylvester, Gregg C., Cheek, James E., Henry, Judy P., Stabler, Sally P., Allen,
     Robert H. Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube
     defects. Teratol 51:311-17, 1995.
 94. Naurath, Hans J., Joosten, Etienne, Riezler, Reiner, Stabler, Sally P., Allen, Robert H., Lindenbaum,
     John. Effects of vitamin B12 folate and vitamin B6 supplements in elderly people with normal serum
     vitamin concentrations. Lancet 346:85-89, 1995.
95. Allen, Robert H. Megaloblastic anemias. In: Cecil Textbook of Medicine, 20th Edition, J. Claude
      Bennett and Fred Plum (Eds.), W.B. Saunders Company, Orlando, FL, 1996, p. 843-51.
96. Sumner, Anne E., Chin, Margaret M., Abrahm, Janet L., Berry, Gerald T., Allen, Robert H., Stabler,
      Sally P. Elevated methylmalonic acid and total homocysteine levels show high prevalence of vitamin
      B12 deficiency after gastric surgery. Ann Intern Med 124:469-76, 1996.
97. Halsted, Charles H., Villanueva, Jesus, Chandler, Carol J., Stabler, Sally P., Allen, Robert H.
      Muskhelishvili, Levan, James, Jill S., Poirier, Lionel. Ethanol feeding of micropigs alters methionine
      metabolism and increased hepatocellular apoptosis and proliferation. Hepatol 23:497-505, 1996.
98. Verhoef, Petra, Stampfer, Meir J., Buring, Julie E., Gaziano, J. Michael, Allen, Robert H., Stabler,
      Sally P., Reynolds, Robert K., Kok, Frans J., Hennekens, Charles H., Willett, Walter C.
      Homocysteine metabolism and risk of myocardial infarction: Relation with vitamin B6, B12 and
      folate. Am J Epid 143:845-59, 1996.
99. Ubbink, Johan B., van der Merwe, Annatjie, Delport, Rhena, Allen, Robert H., Stabler, Sally P.,
      Reizler, Reiner, Vermaak, W.J. Hayward. The effect of a subnormal vitamin B6 status on
      homocysteine metabolism. J Clin Invest 98:177-84, 1996.
100. Koehler, Kathleen M., Romero, Linda J., Stabuber, Patricia M., Pareo-Tubbeth, Shirley L., Liang
      Hwa Chi, Baumgartner, Richard N., Garry, Phillip J., Allen, Robert H., Stabler, Sally P. Vitamin
      supplementation and other variables affecting serum homocysteine and methylmalonic acid
      concentrations in elderly men and women. J Am Coll Nutr 15:364-76, 1996.
101. Herzlich, Barry C., Lichstein, Edgar, Schuloff, Nancy, Weinstock, Martin, Pagala, Murali,
      Ravindram, Kadirimangalam, Namba, Tatsuji, Nietro, F., Javier, Stabler, Sally P., Allen, Robert H.,
      Malinow, M. R. Relationship among homocyst(e)ine, vitamin B12 and cardiac disease in elderly:
      Association between vitamin B12 deficiency and decreased left ventricular ejection fraction. J Nutr
      126:1249S-53S, 1996.
102. Verhof, Petra, Hennekens, Charles H., Allen, Robert H., Stabler, Sally P., Willett, Walter C.,
      Stampfer, Meir J. Plasma total homocysteine and risk of angina pectoris with subsequent coronary
      artery bypass surgery. Am J Cardiol 79:799-801, 1997
103. Stabler, Sally P., Sampson, David A., Wang, Li-Ping, Allen, Robert H. Elevations of serum
      cystathionine and total homocysteine in pyridoxine, folate and cobalamin deficient rats. J Nutr
      Biochem 8:279-89, 1997.
104. Buccellato FR, Lorenzini EC, Scalabrino G, Allen RH, Lindenbaum J. Methylmalonic acid and
      homocysteine as markers of cobalamin deficiency in the neuropathy of total gastrectomized rats. Ital
      J Biochem 46:175-78, 1997.
105. Scalabrino G, Buccellato FR, Tredici G, Morabito A, Lorenzini EC, Allen RH, Lindenbaum J.
      Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats:
       uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord. Exp Neur
       144:258-65, 1997.
106.   Stabler, Sally P., Lindenbaum, John, Allen, Robert H. Vitamin B-12 deficiency in the elderly:
       current dilemmas. Am J Clin Nutr 66:741-749, 1997.
107.   Sundin, David P. and Allen, Robert H. Analysis of Cobalamin and cobalamin analogs by gas
       chromatography-mass spectrometry. Methods Enzymol 281:247-55, 1997.
108.   Kuzminski, Antoinette M., Del Giacco, Eric J., Allen, Robert H., Stabler, Sally P., Lindenbaum,
       John. Effective treatment of cobalamin deficiency with oral cobalamin. Blood 92:1191-98, 1998.
109.   Kuzminski, Antoinette M., Del Giacco, Eric J., Allen, Robert H., Stabler, Sally P. Oral cobalamin
       therapy in patients who absorb it normally. Blood 92:4879-80, 1998.
110.   Susser, Ezra, Brown, Alan S., Klonowski, Emelia, Allen, Robert H., Lindenbaum, John.
       Schizophrenia and impaired homocysteine metabolism: A possible association. Biol Psych 44:141-
       43, 1998.
111.   Savage, David G., Allen, Robert H., Gangaidzo, Innocent T., Levy, Lorraine M. Gwanzura,
       Christine, Moyo, Alpha, Mudenge, Boniface, Kiire, Clement, Mukiibi, Joshua, Stabler, Sally P.,
       Lindenbaum, John. Pancytopenia in Zimbabwe. Am J Med Sci 317:22-32, 1999.
112.   Stabler, Sally P., Estacio, Raymond, Jeffers, Barrett W., Cohen, Jeffrey A., Allen, Robert H.,
       Schrier, Robert W. Total homocysteine is associated with nephropathy in non-insulin-dependent
       diabetes mellitus. Metabolism 48:1096-1101, 1999.
113.   Stabler, Sally P., Allen, Robert H., Fried, Linda P., Pahor, Marco, Kittner, Steven J., Penninx,
       Brenda W.J., Guralnik, Jack M. Racial differences in prevalence of cobalamin and folate deficiencies
       in disabled elderly women. AJCN 70:911-19, 1999.
114.   Penninx, Brenda W.J., Guralnik, Jack M., Ferrucci, Luigi, Fried, Linda P., Allen, Robert H., Stabler,
       Sally P. Vitamin B12 deficiency and depression in physically disabled older women: epidemiologic
       evidence from the Women’s Health and Aging Study. Am J Psych 157:715-21, 2000.
115.   Savage, David G., Ogundipe, Akinola, Allen, Robert H., Stabler, Sally P., Lindenbaum, John.
       Etiology and diagnostic evaluation of macrocytosis. Am J Med Sci 319:343-52, 2000.
116.   Sponne, Isabelle E., Gaire, Delphine, Stabler, Sally P., Droesch, Suzanne, Barbe, Francoise M.,
       Allen, Robert H., Lambert, Daniel A., Nicolas, John-Pierre. Inhibition of vitamin B12 metabolism
       by OH-cobalamin c-lactam in rat oligodendrocytes in culture: a model for studying neuropathy due to
       vitamin B12 deficiency. Neurosci Lett 288: 191-94, 2000.
117.   Look, Markus P., Altfeld, Markus, Kreuzer, Karl A., Riezler, Rainer, Stabler, Sally P., Allen, Robert
       H., Sauerbruch, Tilman, Rockstroh, Jurgen K. Parallel decrease in neurotoxin quinolinic acid and
       soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV
       type 1 disease. AIDS Res Hum Retroviruses 16:1215-21, 2000.
118.   Allen, Robert H. Megaloblastic anemias. In: Cecil Textbook of Medicine, 21st Edition, Lee
       Goldman and J. Claude Bennett (Eds.), W.B. Saunders Company, Philadelphia, PA, 2000, p. 859-67.
119.   Stabler, Sally P., Morton, Ronald L., Winski, Shannon L., Allen, Robert H., White, Carl W. Effects
       of parenteral cysteine and glutathionine feeding in a baboon model of severe prematurity. AJCN 72:
       1548-57, 2000.
120.   Koehler KM, Baumgartner RN, Garry PJ, Allen RH, Stabler SP, Rimm EB. The association of folate
       intake and serum homocysteine in elderly people according to vitamin supplementation and alcohol
       use. AJCN 73: 628-37, 2001.
121.   Rajan, Suparna, Wallace, Jeffrey I., Beresford, Shirley A. A., Brodkin, Kayla I., Allen, Robert H.,
       Stabler, Sally P. Screening for cobalamin deficiency in geriatric outpatients: prevalence and
       influence of synthetic cobalamin intake. JAGS 50:624-30, 2002.
122.   Mudd HS, Cerone R, Schiaffino MC, Fantasia AR, Minniti G, Caruso U, Lorini R, Watkins D,
       Matiaszuk N, Rosenblatt DS, Schwahn B, Rozen R, LeGros L, Kotb M, Capdevila A, Luka Z,
       Finkelstein JD, Tangerman A, Stabler SP, Allen RH, Wagner C. Glycine N-methyltransferase
       deficiency: a novel inborn error causing persistent isolated hypermethioninemia. J Inherit Metab Dis
       24:448-64, 2001.
123.   Look, Markus P., Riezler, Reiner, Berthold, Heiner K., Stabler, Sally P., Schliefer, Kirsten, Allen,
       Robert H., Sauerbruch, Tilman, Rockstroh, Jurgen K. Decrease of elevated N, N-Dimethylglycine
       and N-Methylglycine in Human Immunodeficiency Virus Infection during short-term highly active
       antiretroviral therapy. Metabolism 50:1275-81, 2001.
124.   Yaghmai R, Kashani AH, Geraghty MT, Okoh J, Pomper M, Tangerman A, Wagner C, Stabler SP,
       Allen RH, Mudd SH, Braverman N. Progressive cerebral edema associated with high methionine
       levels and betaine therapy on patient with cystathionine beta-synthase (CBS) deficiency. Am J Med
       Genet 108:57-63, 2002.
125.   Rajan, Suparna, Wallace, Jeffrey I., Beredford, Shirley A.A, Brodkin, Kayla I., Allen, Robert H.,
       Stabler, Sally P. Response of elevated methylmalonic acid to three dose levels of oral cobalamin in
       older adults. JAGS 50:1789-95, 2002.
126.   Stabler, Sally P., Steegborn, Clemens, Wahl, Markus C., Oliveriusova, Jana, Kraus, Jan P., Allen,
       Robert H., Wagner, Conrad, S. Harvey Mudd. Elevated plasma total homocysteine in severe
       methionine adenosyltransferase I/III Deficiency. Metabolism 51: 981-88, 2002.
127.   Maclean KN, Gaustadnes M, Oliveriusova J, Janosik M, Kraus E, Kozich V, Kery V, Skovby F,
       Rudiger N, Ingersley J, Stabler SP, Allen RH, Kraus JP. High homocysteine and thrombosis without
       connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS)
       mutations. Hum Mutat 19:641-55, 2002.
128.   Cottington EM, LaMantia C, Stabler SP, Allen RH, Tangerman A, Wagner C, Zeisel SH, SH Mudd.
       An adverse event associated with a methionine-loading test: a case report. Arterioscler Thromb Vasc
       Biol 22:1046-55, 2002.
129.   Niyikiza, Clet, Baker, Sharyn, Seitz, David E., Walling, Jackie M., Nelson, Katrina, Rusthoven,
       James J., Stabler, Sally P., Paoletti, Paolo, Calvert, A. Hilary and Robert H. Allen. Homocysteine
       and methylmalonic acid: Markers to predict and avoid toxicity from pemetrexed therapy. Mol Cancer
       Ther 1:545-52, 2002.
130.   Maclean KN, Janosik M, Kraus E, Kozich V, Allen RH, Raab BK, Kraus JP. Cystathionine beta-
       synthase is coordinately regulated with proliferation through a redoxsensitive mechanism in cultured
       human cells and Saccharomyces cerevisiae. J Cell Phys 192:81-92, 2002.
131.   Johnson, Mary Ann, Hawthorne, Nicole A., Brackett, Wimberly R., Fischer, Joan G., Gunter, Elaine
       W., Allen, Robert H., and Stabler, Sally P. Hyperhomocysteinemia and vitamin B12 deficiency in
       elderly using Title IIIc nutrition services. AJCN 77:211-20, 2003.
132.   Mudd, S. Harvey, Braverman, Nancy, Pomper, Martin, Tezcan, Kamer, Kronick, Jonathan, Jayakar,
       Parul, Garganta, Cheryl, Ampola, Mary G., Levy, Harvey L., McCandless, Shawn E., Wiltse, Hobart,
       Stabler, Sally P., Allen, Robert H., Wagner, Conrad and Borschel, Marlene. Infantile
       hypermethioninemia and hyperhomocysteinemia due to high methionine intake: a diagnostic trap.
       Mol Genet Metab 79:6-16, 2003.
133.   Mudd SH, Tangerman A, Stabler SP, Allen RH, Wagner C, Zeisel SH, Levy HL. Maternal
       Methionine Adenosyltransferase I/III Deficiency: Reproductive outcomes in a woman with four
       pregnancies. J Inherit Metab Dis 26(5): 443-58, 2003.
134.   Orendac M, Zeman J, Stabler SP, Allen RH, Kraus JP, Bodamer O, Stockler-Ipsiroglu S, Kvasnicka
       J, Kozich V. Homocystinuria due to cystathionine b-synthase deficiency: novel biochemical findings
       and treatment efficacy. J Inherit Metab Dis 26:761-73, 2003.
135.   Augoustides-Savvopoulou P, Luka Z, Karyda S, Stabler SP, Allen, RH, Patsiaoura K, Wagner C,
       Mudd SH. Glycine N-methyltransferase deficiency: a new patient with a novel mutation. J Inherit
       Metab Dis 26:745-59, 2003.
136. Barbosa PR, Doi CS, Stabler SP, Neto LFS, Hirata RDC, Allen, RH, Guerra-Shinohara EM. The
     methionine synthase (MS) A2756G polymorphism is a genetic determinant of S-adenosylmethionine
     (SAM) concentrations in pregnant women. Braz J Pharm Sci 39: Supl. 3:111-14, 2003.
137. Panayiotidis MI, Stabler SP, Allen RH, Ahmad A, White CW. Cigarette smoke extract increases S-
     adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells. Chem Biol Interact
     147:87-97, 2004.
138. Baric, Ivo, Fumic, Ksenija, Glenn, Byron, Cuk, Mario, Schulze, Andreas, Finkelstein, James D.,
     James, S. Jill, Mejaski-Bosnjak, Vlatka, Pazanin, Leo, Pogribny, Igor P., Rados, Marko, Sarnavka,
     Vladimir, Scukanec-Spoljar, Mira, Allen, Robert H., Stabler, Sally P., Uzelac, Lidija, Vugrek,
     Oliver, Wagner, Conrad, Zeisel, Steven, Mudd, S. Harvey. S-adenosylhomocysteine hydrolase
     deficiency in a human: A genetic disorder of methionine metabolism. PNAS 101:4234-39, 2004.
139. Stabler, Sally P., Allen, Robert H. Quantification of serum and urinary S-adenosylmethionine and S-
     adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry. Clin
     Chem 50:365-72, 2004.
140. Stabler, Sally P. and Allen, Robert H. Vitamin B12 deficiency as a world wide problem. Annu Rev
     Nutr 24:299-326, 2004.
141. Sally P. Stabler and Allen, Robert H. Megaloblastic anemias. In: Cecil Textbook of Medicine, 22nd
     Edition, Lee Goldman and Dennis Ausiello (Eds.), W.B. Saunders Company, Philadelphia, PA, 2004,
     p. 1050-57.
142. Wright CB, Lee HS, Paik MC, Stabler SP, Allen RH, Sacco RL. Total homocysteine and cognition
     in a tri-ethnic cohort: the Northern Manhattan Study. Neurology 63:254-60, 2004.
143. Guerra-Shinohara, Elvira Maria, Morita, Olga E., Peres, Sabrina, Pagliusi, Regina A., Neto, Luiz F.
     Sampaio, D’Almeida, Vania, Irazusta, Silvia P., Allen, Robert H., Stabler, Sally P. Low ratio of S-
     adenosylmethionine to S-adenosylhomocysteine is associated with vitamin deficiency in Brazilian
     pregnant women and newborns. AJCN 80:1312-21, 2004.
144. Sacco RL, Anand K, Lee HS, Boden-Albala B, Stabler SP, Allen RH, Paik MC. Homocysteine and
     the risk of ischemic stroke in a triethnic cohort: the Northern Manhattan Study. Stroke 35:2263-69,
     2004.
145. Doshi, Sagar, McDowell, Ian, Goodfellow, Jonathan, Stabler, Sally, Boger, Rainer, Allen, Robert,
     Newcombe, Robert, Lewis, Malcolm, Moat, Stuart. Relationship between S-adenosylmethionine, S-
     adenosylhomocysteine, asymmetric dimethylarginine and endothelial function in healthy human
     subjects during experimental hyper and hypo-homocysteinaemia. Metabolism 54:351-60, 2005.
146. Wright, Clinton B., Paik, Myunghee C., Brown, Truman R., Stabler, Sally P., Allen, Robert H.,
     Sacco, Ralph L., DeCarli, Charles. Total homocysteine is associated with white matter hyperintensity
     volume: the Northern Manhattan Study. Stroke 36:1207-11, 2005.
147. Lewis M, Miller LS, Johnson MA, Dolce EB, Allen RH, Stabler SP. Elevated Methylmalonic Acid is
     Related to Cognitive Impairment in Older Adults Enrolled in an Elderly Nutrition Program. J Nutr
     Elder 24:47-65, 2005.
148. Robertson, Julie, Iemolo, Francesco, Stabler, Sally P., Allen, Robert H., Spence, David J. Vitamin
     B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain
     products. CMAJ 172:1569-73, 2005.
149. Baric I, Cuk M, Fumic K, Vugrek O, Allen RH, Glenn B, Maradin M, Pazanin L, Pogribny IP, Rados
     M, Sarnavka V, Schulze A, Stabler SP, Wagner C, Zeisel SH, Mudd SH. S-adenosylhomocysteine
     hydrolase deficiency: a second patient, the younger brother of the index patient, and outcomes during
     therapy. J Inherit Metab Dis 28:885-902, 2005.
150. Panayiotidias, Mihalis I, Stabler, Sally P., Ahmad, Aftab, Pappa, Aglaia, Legros Jr, Leighton H,
     Hernandez, Daniel, Schneider, B. Kelly, Allen, Robert H., Vasilou, Vasiliou, McCord, Joe M., Kotb,
     Malak, White, Carl W. Activation of a novel isoform of methionine adenosyl transferase 2A and
       increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia. Free Radic
       Biol Med 40:348-58, 2006.
151.   Buist NRM, Glenn B, Vugrek O, Wagner C, Stabler S, Allen RH, Pogribny I, Schulze A, Zeisel SH,
       Baric I, Mudd SH. S-adenosylhomocysteine hydrolase deficiency in a 26 year old man. Accepted J
       Inherit Metab Dis, 2006.
152.   Chandler RJ, Aswani V, Tsai M, Falk M, Wehrli N, Stabler S, Allen R, Sedensky M, Kazazian HH,
       Vendetti CP. Propionyl-CoA and cobalamin metabolism in C. elegans: evidence for a role of
       methylmalonyl-CoA epimerase in intermediary metabolism. In Preparation, 2006.
153.   Guerra-Shinohara EM, Morita OE, Pagliusi RA, Blaia-d’Avila VL, Allen RH, Stabler SP. Elevated
       serum S-adenosylhomocysteine in cobalamin deficient megaloblastic anemia. To be submitted to
       Metabolism, 2006.
154.   Stabler SP, Allen RH, Dolce ET, Johnson MA. Elevated serum s-adenosylhomocysteine in
       cobalamin deficient seniors and response to treatment. Under Review, AJCN, 2006.
155.   Park S, Johnson MA, Shea-Miller K, De Chicchis AR, Allen RH, Stabler SP. Age related hearing
       loss, methylmalonic acid, and vitamin B12 status in older adults. Submitted to AJCN, 2006.
156.   Rusthoven JJ, Niyikiza C, Bunn P, Allen RH, Calvert AH, Stabler SP, Oberthur LE, Paul S, Paoletti
       P. Reducing toxicity from pemetrexed therapy with folic acid and vitamin B12 in patients with
       pleural mesothelioma. To be submitted to J Clin Oncol, 2006.
Patents Held: Quantitative Testing for Vitamin B12
              Inventor:     Robert H. Allen
              Patent No.: 4,188,189
              Date of Issue: February 12, 1980

              Test for Pancreatic Exocrine Function
              Inventor:     Robert H. Allen
              Patent No.: 4,279,886
              Date of Issue: July 21, 1981

              Immunoassay for Measurement of Reticulocytes, and Immunoreactive Reagents for Use
              Therein
              Inventors:    Robert H. Allen, Paul A. Seligman
              Patent No.: 4,332,785
              Date of Issue: June 1, 1982

              Quantitative Testing for Vitamin B12
              Inventor:     Robert H. Allen
              Patent No.: 4,351,822
              Date of Issue: September 28, 1982

              Method for Assaying Vitamin-Containing Compositions for Vitamin Analogues
              Inventor:     Robert H. Allen
              Patent No.: 4,427,780
              Date of Issue: January 24, 1984

              Immunoassay for Measurement of Reticulocytes, and Immunoreactive Reagents for Use
              Therein
              Inventors:    Robert H. Allen, Paul A. Seligman
              Patent No: 4,447,547
              Date of Issue: May 8, 1984

              Preparation of Samples for Vitamin B12 and/or Folate Assay and Assay
              Inventor:     Robert H. Allen
              Patent No.: 4,451,571
              Date of Issue: May 29, 1984

              Assay for Sulfhydryl Amino Acids and Methods for Detecting and Distinguishing
              Cobalamin and Folic Acid Deficiency
              Inventors:    Robert H. Allen, Sally P. Stabler, John Lindenbaum
              Patent No.: 4,940,658
              Date of Issue: June 10, 1990

              Method for Screening and Distinguishing Between Cobalamin and Folic Acid Deficiency
              Based on Assay for Cystathionine and 2-Methylcitric Acid
              Inventors:    Robert H. Allen, Sally P. Stabler, John Lindenbaum
              Patent No.: 5,374,560
              Date of Issue: December 20, 1994
Assays for Sulfhydryl Amino Acids and Methylmalonic Acid and Their Application to
Diagnosis of Cobalamin Deficiency
Inventors:    Robert H. Allen, Sally P. Stabler
Patent No.: 5,438,017
Date of Issue: August 1, 1995

Diagnostic Method for Cobalamin Deficiency
Inventors:    Robert H. Allen, Sally P. Stabler, John Lindenbaum
Patent No.: 5,457,055
Date of Issue: October 10, 1995

Method for Treatment and Prevention of Deficiencies of Vitamins B12, Folic Acid and B6
Inventors:    Robert H. Allen and Sally P. Stabler
Patent No.: 5,563,126
Date of Issue: October 8, 1996

Method for Treatment and Prevention of Deficiencies of Vitamins B12, Folic Acid and B6
Inventors:    Robert H. Allen and Sally P. Stabler
Patent No.: 5,795,873
Date of Issue: August 18, 1998

Method for Treatment and Prevention of Deficiencies of Vitamins B12, Folic Acid and B6
Inventors: Robert H. Allen and Sally P. Stabler
Patent No.: 6,207,651
Date of Issue: March 27, 2001

Method for Treatment, Preventing and Reduction of Elevated Serum Metabolite Levels
Inventors:    Robert H. Allen and Sally P. Stabler
Patent No: 6,297,224
Date of Issue: October 2, 2001

Compositions Treating, Preventing or Reducing Elevated Metabolic Levels
Inventors:    Robert H. Allen and Sally P. Stabler
Patent No: 6,528,496
Date of Issue: March 4, 2003

				
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