Small Business Subcontracting Plan Justification template - DOC

Document Sample
Small Business Subcontracting Plan Justification template - DOC Powered By Docstoc
					SMALL BUSINESS SUBCONTRACTING PLAN JUSTIFICATION
Re. NIH-04- BA- 000

Case Western Reserve University (Case), as a matter of policy, is committed to increasing and
continuing to improve the overall participation of small minority-owned, women-owned, veteran-
owned, and HUBZone businesses, that contract and subcontract with the university. Further, the
university seeks to assure that all of its contractors, subcontractors, and vendors abide by the
spirit and intent of its policy. Case has implemented a rigorous, progressive and innovative
program making supplier diversity a specific objective campus-wide. Case’s commitment is not
limited to the relatively small number of federal research contracts requiring formal small business
subcontracting plans. The Case Supplier Diversity Program covers all contracting and
subcontracting in every facet of university business. It was developed in concert with local
community leaders and key advocacy groups, including the NAACP, Northern Ohio Minority
Business Council, Black Trades Council, Hispanic Business Association, Hard Hatted Women,
National Association of Women Business Owners, and others.

Case’s Office of Material Support continues to invest considerable time in identifying and
classifying vendors as small, small-disadvantaged, women-owned businesses etc. To identify
vendors, we use various online databases, including, but not limited to, the Small Business
Administrations CCR database, BuyVeteran.com, National Association of Women Business
Owners Vendor List, Hispanic Business Vendor List, Small Business Administration HUBZone
Certified Concerns List, State of Ohio HUBZone Vendor List, Consortium of African American
Organizations (CAAO), NAACP Vendor List, Northern Ohio Minority Business Council (NOMBC),
State of Ohio Minority Business Enterprise List, City of Cleveland Minority/Female Business
Enterprise List, and our own vendor database which includes over 4,000 small business vendors
in the various small business vendor categories. We are constantly fine-tuning our database to
add more vendors and to correctly categorize those vendors we have identified.

Selection of small business vendors as sources of the goods and services is accomplished via
two mechanisms. Case maintains a list of the various categories of vendors on its web page at
http://www.case.edu/finadmin/matsupp/suplrdiv.html . Faculty and staff do their own search to
identify a vendor via these databases. In addition, all requisitions sent to Case Purchasing under
federal contracts are required to include a prominent special notification to alert the Purchasing
Buyers to especially target small business vendors.

It is important to point out that in a research contract, the majority of supplies and services are
highly technical, which severely narrows the available vendor pool. Often small businesses that
can provide these goods and services are simply not available. However, throughout the life of
the contract, the Purchasing staff strives to continue to identify potential vendors to increase the
vendor pool, and to meet and hopefully exceed the purchasing quotas agreed upon in the Small
Business Subcontracting Plan.

Below are the estimated supplies, services and travel that will be subcontracted to small business
in the various categories.

Re. supplies and services specific to this project:

Below are the estimated supplies, services and travel that will be subcontracted to small business
in the various categories.

The values cited in this small business subcontracting plan explanation (below) include direct and
indirect costs.




Small Business Subcontracting Plan Justification, Page 1 of 3
Travel Services:
All travel arrangements will be made through Burrows Travel Group, which is a SBA-certified
HUBZone small business concern. Travel will account for approximately $41,000 subcontracting,
for the five years of this contract (~1.7% of total Materials & services).

General Laboratory Supplies:
We make every effort to identify Small Business suppliers of general laboratory supplies. We
have, and will continue, to maximize the dollar amount of supplies that we can obtain from Small
Businesses. Three Small Businesses that we plan to subcontract are LPS Inc., A. Daigger &
Company and PGC Scientific Inc. PGC Scientific Inc. is a woman-owned small business. We
have subcontracted with LPS Inc and PGC Scientific Inc. during the previous contracting period.
All three of these subcontractors supply general lab supplies. We try to procure any item that we
use that is available from these Small Businesses. We actively seek out more Small Businesses.

Categories listed with zero dollar amounts:
As of yet we have not identified any SMALL DISADVANTAGED, VETERAN SMALL
BUSINESSES or SERVICE-DISABLED VETERAN businesses that can supply us with Materials
and Services required to perform the tasks related to this contract. As stated above we actively
seek out all small business.

As required, CWRU will be submitting as the required intervals, the SF-294, Subcontracting
Report for Individual Contracts, and SF-295, Summary Subcontracting Report.

Other Supplies and Services:
The supplies and services to be purchased are, in general, highly specialized which makes
finding vendors that can provide our needs very challenging. Below is a synopsis of the major
types of purchases that will be required: radioligands, specialized chemicals and small molecules,
transfection reagents, tissue culture media, FLEXStation assay reagents, shipping, instrument
service, travel services and general laboratory supplies. Approximately 40% of all Materials and
Services required to perform this contract are available exclusively from large businesses.

Radioligands:
The basis of the PDSP is to assay unknown molecules at various CNS receptors, channels and
transporters (“receptors”). In order to perform the number of assays requested (>6,000) the
most efficient and accepted method is the performance of Radioligand Binding assays.
Radioligand binding assay utilize small chemical molecules, peptides and peptide-mimetic
chemical molecules (“ligands”) that are labeled with a radioactive atom, tritium or 125 iodine, in
most cases (“radioligand”). The radiolabel is used to detect the presence or absence of the
ligand in the receptor’s binding site. Each receptor has a specific radioligands that must be used
in order to determine the binding at that given receptor. The ligand, and hence radioligand, are
sometimes patented or licensed to a sole distributor further limiting our choice of supplier. There
are three suppliers for radioligands, none fall into the targeted categories, Perkin-Elmer NEN Inc.,
Amersham-Pharmacia Inc., and Tocris-Cookson Ltd. Radioligands account for approximately
$272,000, subcontracting, for the five years of this contract (~11% of total Materials & services).

Specialized chemicals and small molecules:
The performance of Radioligand binding assays requires a known competitor of the radioligand
as a positive control. The positive controls for these assays are available only from special
chemical manufacturers. The approximate usage of these reagents is approximately $41,000
subcontracting, for the five years of this contract (~1.7% of total Materials & services).

Transfection reagents:
In order to perform radioligand binding assays the given receptor must be expressed in a cell line.
Due the variety of cell types and receptor types and the need to have assays prepared in a short
period of time cells need to be transfected. Transfection is the process by which we transiently
express heterologous DNA in an immortalized cell line. The methodology of transfection requires



Small Business Subcontracting Plan Justification, Page 2 of 3
the use of specialized reagents. Due to the diversity of our immortalized cell types, receptor DNA
and plasmid type, a versatile reagent must be used. The most versatile reagent is Fugene 6
Transfection Reagent available from Roche BMB, Inc. We have used this reagent successfully
through the initial five-year period of the PDSP with excellent result. Alternative reagents have
been used with a much lower success. The lower success ratio makes substitute reagent use
prohibitive because experiments must be repeated driving up costs in all categories. Additionally,
many test compounds are in very limited quantities and repeated experiments may lead to a lack
of data for these compounds. The approximate usage for Fugene 6 Transfection reagent is
$214,000 subcontracting, for the five years of this contract (~9% of total Materials & services).

Tissue Culture Media:
A major component of each assay requires use of our tissue culture facility. Tissue culture
requires the use of special media, additives, fetal bovine serum, bovine serum, antibiotics and
other special reagents required to grow the varied cell lines. These reagents, medias and
additives are available only from a limited number of sources. The approximate usage of these
reagents is approximately $400,000 subcontracting, for the five years of this contract (~16% of
total Materials & services).

FLEXStation Assay Reagents:
Many assays will utilize the FLEXstation Fluorescence plate reader. The FLEXstation allows for
automation of assays to apply high-throughput techniques and to avoid the use of radioligands.
The assay reagents for this sophisticated machine are proprietary and are available from one
source only, Molecular Devices Inc. The approximate usage for FLEXStation Assay reagents is
$194,000 subcontracting, for the five years of this contract (~8% of total Materials & services).

Shipping:
One requirement of the contract is to use an overnight shipping service for communication and
procurement of the compounds to be assayed. Only large corporation offer this service. Shipping
charges account for approximately $6,000, subcontracting, for the five years of this contract
(~0.2% of total Materials & services).

Instrument Service:
Several instruments are required to perform the Radioligand Binding Assays and FLEXstation
assays. These instruments are highly specialized sophisticated. The instrument components
consist of sensitive detectors of fluorescence, detectors of emission from radioactive-generated
gamma and beta particles, precisely mechanized fluidics transfer apparatus, mechanized sample
transfer, specialized software, computer controllers, and data capabilities. Upkeep and
maintenance of these instruments are arranged through the manufacturers and account for
approximately $82,000, subcontracting, for the five years of this contract (~3.4% of total Materials
& services).

As required, Case will be submitting as the required intervals, the SF-294, Subcontracting Report
for Individual Contracts, and SF-295, Summary Subcontracting Report.




Small Business Subcontracting Plan Justification, Page 3 of 3