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					                          “In The News”
                    February 2 – February 15,
                               2008
     Drug- and Pharmacy- related News Brought to You by the
                    Pharmacy Library People

                                               Cardiology

Ho PM, Peterson ED, Wang L et al. Incidence of death and acute myocardial infarction associated with
stopping clopidogrel after acute coronary syndrome. JAMA. 2008 Feb 6;299(5):532-39.

Mitka M. News: Therapies aim to boost "good" cholesterol. JAMA. 2008 Feb 6;299(5):509-10.

van Acker BA, Botma GJ, Zwinderman AH, et al.; for the REGRESS Study Group. High HDL cholesterol
does not protect against coronary artery disease when associated with combined cholesteryl ester
transfer protein and hepatic lipase gene variants. Atherosclerosis. 2007 Dec 26; [Epub ahead of print]

Beck M. Health journal: Can a drug that helps hearts be harmful to the brain? Wall Street Journal.
February 12, 2008.

Bräuner EV, Forchhammer L, Møller P et al. Indoor particles affect vascular function in the aged: An air
filtration-based intervention study. Am J Respir Crit Care Med. 2008 Feb 15;177(4):419-25. Epub 2007
Oct 11.

Singer AJ, Emerman C, Char DM et al. Bronchodilator therapy in acute decompensated heart failure
patients without a history of chronic obstructive pulmonary disease. Ann Emerg Med. 2008
Jan;51(1):25-34. Epub 2007 Oct 18.

and related commentary . . .

Cydulka RK. All that wheezes is not obstructive pulmonary disease. Ann Emerg Med. 2008 Jan;51(1):35-
6. Epub 2007 Aug 24.

                                                  CNS

Silberstein S, Saper J, Berenson F et al. Oxcarbazepine in migraine headache: A double-blind,
randomized, placebo-controlled study. Neurology. 2008 Feb 12;70(7):548-55.

Communicating about health: A mental health america survey of people with schizophrenia and
providers. Mental Health America. January 2008.

Wilfley DE, Crow SJ, Hudson JI, et al. Sibutramine binge eating disorder research group.

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Efficacy of sibutramine for the treatment of binge eating disorder: A randomized
multicenter placebo-controlled double-blind study. Am J Psychiatry. 2008 Jan;165(1):51-8.

Kim JM, Stewart R, Kim SW, et al. Changes in folate, vitamin B12, and homocysteine associated with
incident dementia. J Neurol Neurosurg Psychiatry. 2008 Feb 5; [Epub ahead of print]

Reger MA, Watson GS, Green PS et al. Intranasal insulin improves cognition and modulates beta-amyloid
in early AD. Neurology. 2008 Feb 5;70(6):440-8. Epub 2007 Oct 17.

Hauser SL, Waubant E, Arnold DL et al for the HERMES Trial Group. B-cell depletion with rituximab in
relapsing-remitting multiple sclerosis. N Engl J Med. 2008 Feb 14;358(7):676-88.

                                                Diabetes

Regier L, Jensen B. Trial summary – preliminary: ACCORD diabetes trial – intensive glucose arm halted
February 6th, 2008. RxFiles. February 8, 2008.

Biddinger SB, Hernandez-Ono A, Rask-Madsen C et al. Hepatic insulin resistance is sufficient to produce
dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 2008 Feb;7(2):125-34.

Christian JG, et al. Clinic-based support to help overweight patients with type 2 diabetes increase
physical activity and lose weight. Arch Intern Med. 2008 Jan 28;168(2):141-6.

and related article:

McManus DD, Ockene IS. Brief supported lifestyle counseling: Modest interventions yield modest
effects. Arch Intern Med. 2008 Jan 28;168(2):129-30.

Goede P, Lund-Andersen H, Parving H-H, Pedersen O. Effect of a multifactorial intervention on
mortality in type 2 diabetes. N Engl J Med. 2008 Feb 7;358(6):580-91.


For safety, NHLBI changes intensive blood sugar treatment strategy in clinical trial of diabetes and
cardiovascular disease. National Heart, Lung and Blood Institute. February 6, 2008.

                                           Drug Compounding

Armitstead J, Loyd L, Pane F et al. Implications of the specialty drug marketplace for health-system
pharmacy: A roundtable discussion. Am J Health Syst Pharm. 2007 Nov 15;64(22):2364-72.

Shane R. Management of chronic diseases in the 21st century: The emerging role of specialty
pharmacies. Am J Health Syst Pharm. 2007 Nov 15;64(22):2382-5.

Lizarralde M, Gutiérrez SH, Venegas A. Clinical efficacy of botulinum toxin type A reconstituted and
refrigerated 1 week before its application in external canthus dynamic lines. Dermatol Surg. 2007
Nov;33(11):1328-33; discussion 1333.

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                                               Drug Safety


Advisory: Fentanyl transdermal pain patches recalled due to health risk. Health Canada. 2008 Feb
14;2008-29.

Baxter's multiple-dose vial heparin linked to severe allergic reactions: FDA advises health care
practitioners to switch suppliers and limit use of drug until problem identified. FDA News. February 11,
2008

Dillman JR, Ellis JH, Cohan RH et al. Allergic-like breakthrough reactions to gadolinium contrast agents
after corticosteroid and antihistamine premedication. AJR Am J Roentgenol. 2008 Jan;190(1):187-90.

Early communication about an ongoing safety review Botox and Botox Cosmetic (botulinum toxin type
A) and Myobloc (botulinum toxin type B). US FDA. February 8, 2008.

Carey B. Making sense of the great suicide debate. New York Times. February 10, 2008.

Fahrenkopf AM Sectish TC, Bargar LK et al. Rates of medication errors among depressed and burnt out
residents: Prospective cohort study. BMJ. 2008 Feb 7; [Epub ahead of print]

and related editorial:

McLay J, Ross S. Medication errors caused by junior doctors. BMJ. 2008 Feb 7; [Epub ahead of print].

                                        Environmental Concerns

Collier R. Canada's nuclear fallout. CMAJ. 2008 Feb 4; [Epub ahead of print]

Collier R. A black sheep in the nuclear family. CMAJ. 2008 Feb 14; [Epub ahead of print]

                                              GI Disorders

Tytgat GN, McColl K, Tack J et al. New algorithm for the treatment of gastro-oesophageal reflux disease.
Aliment Pharmacol Ther. 2008 Feb 1;27(3):249-56. Epub 2007 Oct 31.

                                           Infectious Disease

Surveillance for methicillin-resistant Staphylococcus aureus in Canadian hospitals - A report update from
the Canadian nosocomial infection surveillance program . February 2008. Canadian Communicable
Disease Report: Public Health Agency of Canada.

Altman K. Mutant flu virus is found that resists popular drug. New York Times. January 31, 2008.

McNeil Jr. DG. Nets and new drug make inroads against malaria. New York Times. February 1, 2008.


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Alves Galvão MG, Rocha Crispino Santos MA, Alves da Cunha AJL. Amantadine and rimantadine for
influenza A in children and the elderly. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.:
CD002745.

Al-Rawahi GN, Schreader AG, Porter SD et al. Methicillin-sesistant Staphylococcus aureus nasal carriage
among injection drug users: Six years later. J Clin Microbiol. 2008 Feb;46(2):477-9. Epub 2007 Nov 26.

Wilson W, Taubert K et al. Prevention of infective endocarditis: Guidelines from the American Heart
Association. Circulation. 2007; 116: 1736-1754.

                                              Men’s Health

Shariat SF, Lamb DJ, Iyengar RG et al. Herbal/hormonal dietary supplement possibly associated with
prostate cancer progression. Clin Cancer Res. 2008 Jan 15;14(2):607-11.

Bettocchi C, Verze P, Palumbo F et al. Ejaculatory disorders: Pathophysiology and management. Nat
Clin Pract Urol. 2008 Feb;5(2):93-103.




                                                Oncology

Wilt TJ, MacDonald R. Rutks I et al. Systematic review: Comparative effectiveness and harms of
treatments for clinically localized prostate cancer. Ann Intern Med. 2008 Mar 18; 2008(0).

Blitshteyn S, Crook JE, Jaeckle KA. Is there an association between meningioma and hormone
replacement therapy? J Clin Oncol. 2008 Jan 10;26(2):279-82

Research Team Identifies Novel Anti-Cancer Drug from the Sea. Newswise February 11, 2008.

refers to:

Wrasidlo W, Mielgo A, Torres VA et al. The marine lipopeptide somocystinamide A triggers apoptosis via
caspase 8. Proc Natl Acad Sci U S A. 2008 Feb 11; [Epub ahead of print]

Press release. Avado Study of Avastin plus Docetaxel chemotherapy showed improved progression-free
survival in patients with advanced breast cancer. South San Francisco CA: Genentech; February 12,
2008.

                                             Ophthalmology

Rashid S, Jin Y, Ecoiffier T et al. Topical omega-3 and omega-6 Fatty acids for treatment of dry eye. Arch
Ophthalmol. 2008 Feb;126(2):219-25.

                                  OTCs, Nutrition, NHPs, Life Style, etc.

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Kechagias S, Ernersson A, Dahlqvist O et al. Fast food based hyper-alimentation can induce rapid and
profound elevation of serum alanine aminotransferase in healthy subjects. Gut. 2008 Feb 14; [Epub
ahead of print]

Ma Y, Li W, Olendzki BC et al. Dietary quality 1 year after diagnosis of coronary heart disease. J Am Diet
Assoc. 2008 Feb;108(2):240-6.

and related:

Ma Y, Chiriboga DE, Olendzki BC. Dietary evaluation and counseling should be emphasized for coronary
heart disease patients. J Am Diet Assoc. 2008 Feb;108(2):246-7.

Gregory PJ, Sperry M, Wilson AF. Dietary supplements for osteoarthritis. Am Fam Physician. 2008 Jan
15;77(2):177-84.


                                                   Pain

Arnold LM, Fishman SM, Simon LS. Overcoming barriers to pain relief: An interactive patient case
symposium. Medscape. CME: Release date: February 4, 2008; valid for credit through February 4,
2009.
(Medscape is free but registration is required.)

                                                Pediatrics

Sathyanarayana S, Karr CJ, Lozano P, et al. Baby care products: Possible sources of infant phthalate
exposure. Pediatrics. 2008 Feb;121(2):e260-8.

Baird G, Pickles A, Simonoff E et al. Measles vaccination and antibody response in autism spectrum
disorders. Arch Dis Child. 2008 Feb; [epub ahead of print].

El Saleeby CM, Somes GW, DeVincenzo JP, Gaur AH. Risk factors for severe respiratory syncytial virus
disease in children with cancer: The importance of lymphopenia and young age. Pediatrics. 2008
Feb;121(2):235-43.

Yorita KL, Holman RC, Sejvar JJ et al. Infectious disease hospitalizations among infants in the United
States. Pediatrics. 2008 Feb;121(2):244-52.

Tarkan L. Ear infections too often misdagnosed, then overtreated. The New York Times. Feb 13, 2008.

                                             Pharmaceutics

Wermeling DP, Banks SL, Hudson DA et al. Microneedles permit transdermal delivery of a skin-
impermeant medication to humans. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2058-63. Epub 2008
Feb 4.

                                             Rheumatology
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Sheridan C. Small molecule challenges dominance of TNF-alpha inhibitors. Nat Biotechnol. 2008
Feb;26(2):143-4.

                                          Socioeconomic Topics

Liu L, Cline RR, Schondelmeyer SW, Schommer JC. Pharmaceutical expenditures as a correlate of
population health in industrialized nations. Ann Pharmacother. 2008 Feb 13; [Epub ahead of print]


Newton PN, Fernández FM, Plançon A et al. A collaborative epidemiological investigation into the
criminal fake artesunate trade in South East Asia. PLoS Med. 2008 Feb 12;5(2):e32 [Epub ahead of
print].

Riess K-A. Martha Blum, 94: Writer: Pharmacist survived the Holocaust to publish her first novel at 86.
All told, the Saskatoon teacher and musician wrote three books -- All in longhand and all while lying in
bed. As a result, her duvet covers were forever stained with ink. Globe and Mail. February 13, 2008.

Collier R. Cigarette ads return to Canadian magazines. CMAJ. 2008 Feb 12;178(4):384-5.

Demers V, Melo M, Jackevicius C et al. Comparison of provincial prescription drug plans and the impact
on patients' annual drug expenditures. CMAJ. 2008 Feb 12;178(4):405-9.

Dhalla I, Laupacis A. Moving from opacity to transparency in pharmaceutical policy. CMAJ. 2008 Feb
12;178(4):428-31.

is related to the article listed below:

Tierney M, Manns B; Members of the Canadian Expert Drug Advisory Committee. Optimizing the use of
prescription drugs in Canada through the Common Drug Review. CMAJ. 2008 Feb 12;178(4):432-5.

Dunn S, Brown TE, Alldred J. Availability of emergency contraception after its deregulation from
prescription-only status: A survey of Ontario pharmacies. CMAJ. 2008 Feb 12;178(4):423-4.

Sheehy O, LeLorier J, Rinfret S. Restrictive access to clopidogrel and mortality following coronary stent
implantation. CMAJ. 2008 Feb 12;178(4):413-20.

is related to the article below:

Suissa S. Mortality benefit from unrestricted access to clopidogrel: Too good to be true? CMAJ. 2008
Feb 12;178(4):425-7.

Investor relations. Latest news: Biovail Receives Letter Related to 2003 Cardizem(R) LA Launch
Activities from U.S. Attorney's Office. Toronto ON: Biovail Corporation. February 1, 2008.

Health Canada to review cotton swab labeling. CBC News. February 8, 2008.

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McNeil Jr. DG. New food formula: Tastes fine, kills worms. New York Times. February 5, 2008.

Pawaskar MD, Joish VN, Camacho FT et al. The influence of co-morbidities on prescribing
pharmacotherapy for insomnia: Evidence from US national outpatient data 1995-2004. J Med Econ.
2008; 11(1): 41-56.

McGee MK. Marriott e-health record system spots medical mishaps. InformationWeek. January 28,
2008.

Kabel M. Wal-Mart expands in-store health clinics. Yahoo! Finance. February 7, 2008.

Nahata MC. Tips for writing and publishing an article. Ann Pharmacother. 2008 Jan 22; [Epub ahead of
print]

Saul, S. Drug ads raise questions for heart pioneer. New York Times. February 7, 2008

Austvoll-Dahlgren A, Aaserud M, Vist G et al. Pharmaceutical policies: Effects of cap and co-payment on
rational drug use. Cochrane Database of Systematic Reviews 2008, Issue 1.

Hughes B. 2007 FDA drug approvals: A year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.

Devil in the details. Nat Med. 2008 Feb;14(2):105-6.

Hayden EC. Battle over eye medicine gives drugmaker a dose of reality. Nat Med. 2008 Feb;14(2):108.

Berenson A. Lilly Considers $1 Billion Fine to Settle Case. The New York Times. January 31, 2008.

Korkki P. Going global with concerns on health costs. New York Times. Febrary 10, 2008.

Van Baal PHM, Polder JJ, de Wit A et al. Lifetime medical costs of obesity: Prevention no cure for
increasing health expenditure. PLoS Medicine. 2008 February: 5(2): e29.

FDA proposes guidance for dissemination of information on unapproved uses of medical products:
Agency accepting public comments for 60 days. FDA News. February 15, 2008.

The 10th annual health care in Canada survey: A national survey of health care providers, managers, and
the public. Toronto ON: Merck Frosst Canada Ltd.; 2007-2008.

Lawrence S. 2007--a banner year for biotech. Nat Biotechnol. 2008 Feb;26(2):150.

                                        Substance Use Disorders

Britton J. Head to head: Should doctors advocate snus and other nicotine replacements? Yes. BMJ.
2008 Feb 16;336(7640):358.

and . . .

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Macara AW. Should doctors advocate snus and other nicotine replacements? No. BMJ. 2008 Feb
16;336(7640):359.

George DT, Gilman J, Hersh J et al. Neurokinin 1 receptor antagonism as a possible therapy for
alcoholism. Science. 2008 Feb 14; [Epub ahead of print].

Vandrey RG, Budney AJ, Hughes JR, Liguori A. A within-subject comparison of withdrawal symptoms
during abstinence from cannabis, tobacco, and both substances. Drug Alcohol Depend. 2008 Jan 1;92(1-
3):48-54. Epub 2007 Jul 23.

Thomson WM, Poulton R, Broadbent JM et al. Cannabis smoking and periodontal disease among young
adults. JAMA. 2008 Feb 6;299(5):525-531.

and related editorial:

Philippe P. Hujoel. Destructive periodontal disease and tobacco and cannabis Smoking JAMA. 2008 Feb
6;299(5):574-575.

Walters ST, Roudsaria BS, Vadera AM, Harrisa TR. Correlates of protective behavior utilization among
heavy-drinking college students. Addict Behav. 2007 Nov;32(11):2633-44. Epub 2007 Jun 29

                                            Women’s Health

Vega CP. Supplementation with calcium and vitamin D: Efficacy against fracture and total mortality: A
best evidence review. Medscape. CME/CE: Release date: February 5, 2008; valid for credit through
February 5, 2009.
(Medscape is free but registration is required.)

Lie D. Black cohosh and menopausal symptoms. Medscape. CME/CE: Release date: February 1, 2008;
valid for credit through February 1, 2009.
(Medscape is free but registration is required.)

Jansson LM, Choo R, Velez ML et al. Methadone maintenance and breastfeeding in the neonatal period.
Pediatrics. 2008 Jan;121(1):106-14.

Wen SW, Chen XK, Rodger M et al. Folic acid supplementation in early second trimester and the risk of
preeclampsia. Am J Obstet Gynecol. 2008 Jan;198(1):45.e1-7.

Women suffering from monthly bouts of PMS may soon be able to spray it away. WebMD Video.
[February 9, 2008].

U.S. Preventative Services Task Force. Clinical Guidelines: Screening for bacterial vaginosis in pregnancy
to prevent preterm delivery: U.S. Preventive Services Task Force recommendation statement. Ann Intern
Med. 5 February 2008; 148 (3): 214-219.

is related to:

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Nygren P, Fu R, Freeman M et al. Evidence on the benefits and harms of screening and treating
pregnant women who are asymptomatic for bacterial vaginosis: An update review for the U.S.
Preventive Services Task Force. Ann Intern Med. 5 February 2008; 148(3): 220-233.

Barry LC, Allore HG, Guo Z et al. Higher burden of depression among older women: The effect of onset,
persistence, and mortality over time. Arch Gen Psychiatry. 2008 Feb;65(2):172-8.

Lafleur J, McAdam-Marx C, Kirkness C, Brixner DI. Clinical risk factors for fracture in postmenopausal
osteoporotic women: A review of the recent literature (March). Ann Pharmacother. 2008 Jan 29; [Epub
ahead of print]

Barclay L. Contraceptive ring more likely used for nondaily method than the patch. Medscape. CME:
Release date: February 7, 2008; valid for credit through February 7, 2009.
(Medscape is free but registration is required.)

                                           Faculty Publications

Hurley KF, Sargeant J, Duffy J, Sketris I, Sinclair D, Ducharme J. Perceptual reasons for resistance to
change in the emergency department use of holding chambers for children with asthma. Ann Emerg
Med. 2008 Jan;51(1):70-7.

Smith AJ, Sketris I, Cooke C, Gardner D, Kisely S, Tett SE. A comparison of antidepressant use in Nova
Scotia, Canada and Australia. Pharmacoepidemiol Drug Saf. 2008 Jan 8; [Epub ahead of print]


Gaikwad R, Sketris I, Shepherd M, Duffy J. Evaluation of accuracy of drug interaction alerts triggered by
two electronic medical record systems in primary healthcare. Health Informatics J. 2007 Sep;13(3):163-
77.

Gallant CR, MacKinnon NJ, Sprague DA. Disease management in Canada: Surmounting barriers to
adoption. Healthcare Management Forum. 2007 Winter;27-32.

                                              About Faculty

Guiding the system. OutFront [Dalhousie University] 2007 Fall/Winter;2(2):7.
[. . . about Ingrid Sketris and some of her research; follow the link and look for the story under “page” 7
(9 of 20.)]

                                         The End Until Next Time!




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