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Principal Investigator/Program Director (Last, first, middle): Balish, Edward

Provide the following information for the key personnel in the order listed on Form Page 2. Photocopy this page or follow this format for each person. NAME POSITION TITLE

Edward Balish

Professor and Principal Investigator

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY (If applicable)

University of Scranton, PA University of Syracuse, NY University of Syracuse, NY


1957 1959 1963

Biology Microbiology Microbiology

RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and honors. Include present membership on any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the past three years and to representative earlier publications pertinent to this application. If the list of publications in the last three years exceeds two pages, select the most pertinent publications. DO NOT EXCEED TWO PAGES.

1957-59 1959-61 1961-63 1963-66 1966-69 1969-76 1976-2000 1980-96 1988-90 1991-2000 2001-present

Research Assistant, Syracuse Univ. Biological Research Laboratories U.S. Publ. Hlth. Serv. Predoc. Fellow at Syracuse Univ., Dept. Microbiol. Research Associate, University of Syracuse Resident Research Associate, Argonne Nat'l. Lab. Sr. Scientist & Div. Head of Microbiol., Oak Ridge Associated Universities Assoc. Prof., Surgery & Med. Microbiology, Univ. of Wisconsin Med. School Prof. of Surg. & Med. Microbiol./Immunol., Univ. of Wisc. Med. Sch. Director, University of Wisconsin Gnotobiotic Research Lab. Act. Chrm., Dept. of Med. Microbiol./Immunol., Univ. of Wisc. Med. School Affiliate Member, Dept. of Animal Hlth. & Biomed. Sci., College of Agricultural and Life Sciences, Univ. of Wisconsin-Madison Professor, Dept. of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC

Fellowships, Honors & Offices Pi Sigma Sigma Xi 1959-61 U.S. Public Health Service Predoctoral Fellow (NIH) 1963-66 Atomic Energy Commission Postdoctoral Fellowship at Argonne National Lab., Argonne, IL 1970-72 Amer. Institute of Biological Sciences (AIBS), Selected as a lecturer in Radiation Biology (National Lecture Program) 1973-75 Board of Directors, Assoc. for Gnotobiotics - Research and Technology 1974-75 Vice President, Assoc. for Gnotobiotics - Research and Technology 1974Certification by American Board of Microbiology as a specialist in public health and medical laboratory microbiology 1975-76 President, Assoc. for Gnotobiotics - Research and Technology 1975Fellow, American Academy of Microbiology 1981Registered Agent for Assoc. for Gnotobiotics 1981-85 Board of Directors, Assoc. for Gnotobiotics - Research and Technology 1987Int'l. Comm. to select the winner of the Kuwait Prize for Basic Microbiology, Kuwait 1987-93 Board of Directors, Int'l. Assoc. for Gnotobiology 1988Watkins Visit. Prof., Witchita State Univ., Witchita, Kansas 1991-93 Councillor, The Society for Microecology and Disease (SOMED) 1992-93 Vice-Pres. (Pres.-Elect) of the Assoc. for Gnotobiotics Res. & Technology 1992-95 Board of Directors, Assoc. for Gnotobiotics Research and Technology 1993-94 President, Assoc. for Gnotobiotics - Research and Technology 1994-96 Int’l. Advisory Panel for the XII Symposium on Gnotobiology, Honolulu, Hawaii 1996-99 Int’l. Advisory Panel for the XIII Symposium on Gnotobiology, Stockholm, Sweden 1999-02 Councilor, The International Association for Gnotobiology Publications (selected from 196 peer reviewed publications): 1. Dieleman LA. Arends A. Tonkonogy SL. Goerres MS. Craft DW. Grenther W. Sellon RK. Balish E. Sartor RB. Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice. Infection & Immunity. 68(9):5107-13, 2000 Sep. 2. Wagner RD. Pierson C. Warner T. Dohnalek M. Hilty M. Balish E. Probiotic effects of feeding heat-killed Lactobacillus acidophilus and Lactobacillus casei to Candida albicans-colonized immunodeficient mice. Journal of Food Protection. 63(5):638-44, 2000 May. 3. Kawachi S. Jennings S. Panes J. Cockrell A. Laroux FS. Gray L. Perry M. van der Heyde H. Balish E. Granger DN. Specian RA. Grisham MB.
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Cytokine and endothelial cell adhesion molecule expression in interleukin-10-deficient mice. American Journal of Physiology - Gastrointestinal & Liver Physiology. 278(5):G734-43, 2000 May. 4. Jones-Carson J. Vazquez-Torres A. Warner T. Balish E. Disparate requirement for T cells in resistance to mucosal and acute systemic candidiasis. Infection & Immunity. 68(4):2363-5, 2000 Apr. 5. Park SH. Benlagha K. Lee D. Balish E. Bendelac A. Unaltered phenotype, tissue distribution and function of Valpha14(+) NKT cells in germ-free mice. European Journal of Immunology. 30(2):620-5, 2000 Feb. 6. Balish E. Wagner RD. Vazquez-Torres A. Jones-Carson J. Pierson C. Warner T. Mucosal and systemic candidiasis in IL-8Rh-/- BALB/c mice. Journal of Leukocyte Biology. 66(1):144-50, 1999 Jul. 7. Schultz M. Tonkonogy SL. Sellon RK. Veltkamp C. Godfrey VL. Kwon J. Grenther WB. Balish E. Horak I. Sartor RB. IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. American Journal of Physiology. 276(6 Pt 1):G1461-72, 1999 Jun. 8. Maldonado MA. Kakkanaiah V. MacDonald GC. Chen F. Reap EA. Balish E. Farkas WR. Jennette JC. Madaio MP. Kotzin BL. Cohen PL. Eisenberg RA. The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice. Journal of Immunology. 162(11):6322-30, 1999 Jun 1. 9. Song F. Ito K. Denning TL. Kuninger D. Papaconstantinou J. Gourley W. Klimpel G. Balish E. Hokanson J. Ernst PB. Expression of the neutrophil chemokine KC in the colon of mice with enterocolitis and by intestinal epithelial cell lines: effects of flora and proinflammatory cytokines. Journal of Immunology. 162(4):2275-80, 1999 Feb 15. 10. Vazquez-Torres A. Jones-Carson J. Wagner RD. Warner T. Balish E. Early resistance of interleukin-10 knockout mice to acute systemic candidiasis. Infection & Immunity. 67(2):670-4, 1999 Feb. 11. Jones-Carson J. Balish E. Uehling DT. Susceptibility of immunodeficient gene-knockout mice to urinary tract infection. Journal of Urology. 161(1):338-41, 1999 Jan. 12. Sellon RK. Tonkonogy S. Schultz M. Dieleman LA. Grenther W. Balish E. Rennick DM. Sartor RB. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infection & Immunity. 66(11):5224-31, 1998 Nov. 13. Balish E. Wagner RD. Vazquez-Torres A. Pierson C. Warner T. Candidiasis in interferon-gamma knockout (IFN-gamma-/-) mice. Journal of Infectious Diseases. 178(2):478-87, 1998 Aug. 14. Hopkins WJ. Gendron-Fitzpatrick A. Balish E. Uehling DT. Time course and host responses to Escherichia coli urinary tract infection in genetically distinct mouse strains. Infection & Immunity. 66(6):2798-802, 1998 Jun. 15. Wagner RD. Pierson C. Warner T. Dohnalek M. Farmer J. Roberts L. Hilty M. Balish E. Biotherapeutic effects of probiotic bacteria on candidiasis in immunodeficient mice. Infection & Immunity. 65(10):4165-72, 1997 Oct. 16. Wagner RD. Warner T. Roberts L. Farmer J. Balish E. Colonization of congenitally immunodeficient mice with probiotic bacteria. Infection & Immunity. 65(8):3345-51, 1997 Aug. 17. Vazquez-Torres A. Balish E. Macrophages in resistance to candidiasis. Microbiology & Molecular Biology Review (Washington, DC). 61(2):170-92, 1997 Jun. 18. Uehling DT. Hopkins WJ. Balish E. Xing Y. Heisey DM. Vaginal mucosal immunization for recurrent urinary tract infection: phase II clinical trial. Journal of Urology. 157(6):2049-52, 1997 Jun. 19. Jones-Carson J. Vazquez-Torres FA. Balish E. B cell-independent selection of memory T cells after mucosal immunization with Candida albicans. Journal of Immunology. 158(9):4328-35, 1997 May 1. 20. Engle, Sandra J., Ormsby, Ilona, Pawlowski, Sharon, Boivin, Gregory P., Croft, Joanne, Balish, Edward and Doetschman, Tom. November 15, 2002 Elimination of Colon Cancer in Germ-free Transforming Growth Factor Beta 1-deficient Mice. Cancer Research. 62, 6362-6366. 21. Schofield, David A., Westwater, Caroline, Warner, Thomas, Nicholas, Peter J., Paulling, Emily E. and Balish, Edward. Hydrolytic Gene Expression during Oroesophageal and Gastric Candidiasis in Immunocompetent and Immunodeficient Gnotobiotic Mice. The Journal of Infectious Diseases. 188:591-9. August, 2003. 22. Luberto, C., D. Taraskiewicz, B. Martinez-Marino, B. Bolanos, P. Chitano, D. L. Toffaletti, G. M. Cox, J. R. Perfect, Y. A. Hannun, E. Balish, and M. Del Poeta. 2003. Identification of App1 as regulator of phagocytosis and virulence of Cryptococcus neoformans. Journal of Clinical Investigation (In press). 23. Dolan, J.W., A. C. Bell, B.Hube, M.Schaller, T. F. Warner and E.Balish. 2003 Candida albicans PLD1 Activity is Required for Full Virulence. Medical Mycology (In Press)

_________________________________________________________________________________________________________________________ ______________ PHS 398 (Rev. 5/95) (Form Page 6) Page _____ FF Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b.