Polycystic Kidney Disease and Tuberous Sclerosis Complex

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					Polycystic Kidney Disease and Tuberous Sclerosis Complex: Building Bridges to the Future March 9-10, 2006
Organizing Committee Peter Harris (Co-Chair) Cheryl Lyn Walker (Co-Chair) Lisa Guay-Woodford Lisa Henske Mayo Clinic UT MD Anderson Cancer Center University of Alabama Fox Chase Cancer Center

Workshop Agenda Thursday, March 9, 2006
12:00-12:45 12:45-1:00 Lunch provided Welcome Vicky Whittemore Lorrie Rome

Tuberous Sclerosis Alliance PKD Foundation

Session I: Introduction to PKD and TSC
Chair: Cheryl Walker 1:00-2:00 Vicente Torres Peter Harris Discussion Lisa Henske Stefan Somlo Discussion Clinical aspects of PKD and TSC Genetics of PKD and TSC

2:00-3:00

Overview of TSC research Overview of PKD Research

3:00-4:00

Greg Germino Animal models for PKD David Kwiatkowski Animal models for TSC Discussion Break

4:00-4:30

Session IIa: Research Focus Areas
Chair: Lisa Henske 4:30-5:30 Cell Signaling Brendan Manning Thomas Weimbs Jim Calvet Discussion

PI3K Signaling in TSC PI3K Signaling in PKD Ca+ and cAMP signaling in PKD

5:30-6:15

Cell Cycle Cheryl Walker Jing Zhou Adjourn for the day

p27 alterations in TSC Cell cycle aberrations in PKD

6:15

Friday, March 10, 2006 Session IIb: Research Focus Areas (cont’d)
Chair: Peter Harris 7:00-8:00 8:00-8:45 Continental breakfast in meeting room Cilia and Cell Polarity Lisa Henske Brad Yoder Discussion

Hamartin (TSC1) localization to centrioles Cilia in the PKD and roles in the nervous system

8:45-9:30

Vesicular Trafficking and Protein Targeting Ray Yeung Trafficking defects in TSC Lisa Guay-Woodford Protein targeting defects in PKD Gerd Walz Title needed Discussion Cytoskeleton and Cell Adhesion Vera Krymskya Rho signaling in TSC Angela Wandinger-Ness Cytoskeletal aberrations in PKD Discussion Break Targeted Therapies John Bissler Sandy Dabora Charles Edelstein Vincent Gattone Lunch provided

9:30-10:15

10:15-10:45 10:45-12:00

mTOR as a therapeutic target in TSC Rapamycin clinical trials in TSC Rapamycin, an effective treatment in PKD? Vasopressin receptor antagonists in PKD treatment

12:00-1:00

Session III: Workshop Highlights, Future Directions and Research Needs
Chairs: Cheryl Walker & Peter Harris 1:00 Open-ended group discussion Adjournment

TSC/PKD Workshop Information Sheet

Meeting Dates: March 9-10, 2006 The workshop starts at 12:00 noon on Thursday, March 9th with a lunch. Meeting Site: Chicago O’Hare Hilton (can be reached from the airport via tunnel on foot) Presentation Specifics Talk length for each session Session I 20 min with 10 min for discussion Session IIa 15 min with 5 minutes for discussion Session IIb 15 min with 5 minutes for discussion Session III Group Discussion – open ended Flash drives Both PC and Mac laptops will be available for use by the speakers. Please bring your presentation on a flash drive for quicker loading. Flight Arrangements You must book your own flight. The PKD Foundation will reimburse the cost of your airfare up to $300. Please book early for cheaper flights. Reimbursement forms will be in the packets given to those attending the Workshop.


				
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